1. Morphological and immunohistochemical characteristics of diffuse seminoma in horses: A case report.
- Author
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Batista LAS, de Alencar Santos Júnior D, Rodrigues AS, Menezes AA, do Nascimento MJR, de Galiza GJN, de Medeiros Dantas AF, and Frade MTS
- Subjects
- Male, Animals, Horses, Ultrasonography veterinary, Immunohistochemistry veterinary, Proto-Oncogene Proteins c-kit analysis, Proto-Oncogene Proteins c-kit metabolism, Octamer Transcription Factor-3 analysis, Octamer Transcription Factor-3 metabolism, Seminoma veterinary, Seminoma pathology, Seminoma surgery, Testicular Neoplasms veterinary, Testicular Neoplasms pathology, Testicular Neoplasms surgery, Orchiectomy veterinary, Horse Diseases pathology, Horse Diseases surgery, Horse Diseases diagnostic imaging
- Abstract
The present study describes the morphological and immunohistochemical characteristics of a case of diffuse seminoma in a 16-year-old male mixed-breed horse. According to the owner, the animal's left testicle had been gradually increasing in size over a period of 2 months. On palpation, the testicle had a firm consistency, with no sensitivity to digital pressure, was adhered to the scrotum and measuring 16 cm × 8 cm. In the ultrasound examination, it presented a heterogeneous texture and areas of hypoechogenic echogenicity without visualization of the mediastinum. Therefore, the bilateral orchiectomy was performed. After the surgical procedure, it was found that the affected testicle presented a firm mass measuring 9 cm × 7 cm × 3.5 cm. Histologically, a multilobulated, non-encapsulated and invasive tumour mass was found, which replaced the seminiferous tubules, consisting of polygonal cells arranged in a mantle that varied from cohesive to loosely cohesive, supported by a scarce fibrous stroma. In the immunohistochemical examination, the neoplastic cells showed positive immunolabelling for OCT4 and C-KIT. In this report, the physical examination combined with the ultrasonographic examination were fundamental to the therapeutic management of the case, and the final diagnosis was made after histopathological and immunohistochemical tests., (© 2024 Wiley‐VCH GmbH. Published by John Wiley & Sons Ltd.)
- Published
- 2024
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