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BRAFV600E and KIT immunoexpression in early-stage melanoma.
- Source :
-
Anais brasileiros de dermatologia [An Bras Dermatol] 2019 Oct 17; Vol. 94 (4), pp. 458-460. Date of Electronic Publication: 2019 Oct 17 (Print Publication: 2019). - Publication Year :
- 2019
-
Abstract
- Melanoma is widely known as the most lethal skin cancer. Specific tumor-related mortality can be significantly reduced if diagnosis and treatment are properly performed during initial phases of the disease. The current search for biomarkers in early-stage melanomas is a high-priority challenge for physicians and researchers. We aimed to assess the immunoexpression of BRAFV600E and KIT in a case series consisting of 44 early-stage melanomas. Formalin-fixed paraffin-embedded samples were systematically evaluated using a semi-quantitative method based on scores of percentage and intensity for immunostained tumor cells. We observed significant concordance between BRAFV600E and KIT immunoexpression in thin invasive melanomas. Our findings corroborate previous evidence showing abnormal expression of proteins associated with MAPK intracellular signaling pathway in early-stage melanomas.
- Subjects :
- Adult
Aged
Aged, 80 and over
Disease Progression
Female
Humans
Immunohistochemistry
Male
Middle Aged
Mitogen-Activated Protein Kinases analysis
Mutation
Neoplasm Staging
Proto-Oncogene Proteins B-raf genetics
Proto-Oncogene Proteins c-kit genetics
Retrospective Studies
Young Adult
Melanoma pathology
Proto-Oncogene Proteins B-raf analysis
Proto-Oncogene Proteins c-kit analysis
Skin Neoplasms pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1806-4841
- Volume :
- 94
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Anais brasileiros de dermatologia
- Publication Type :
- Academic Journal
- Accession number :
- 31644622
- Full Text :
- https://doi.org/10.1590/abd1806-4841.20198349