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BRAFV600E and KIT immunoexpression in early-stage melanoma.

Authors :
Germano A
Cardili L
Carapeto FCL
Landman G
Source :
Anais brasileiros de dermatologia [An Bras Dermatol] 2019 Oct 17; Vol. 94 (4), pp. 458-460. Date of Electronic Publication: 2019 Oct 17 (Print Publication: 2019).
Publication Year :
2019

Abstract

Melanoma is widely known as the most lethal skin cancer. Specific tumor-related mortality can be significantly reduced if diagnosis and treatment are properly performed during initial phases of the disease. The current search for biomarkers in early-stage melanomas is a high-priority challenge for physicians and researchers. We aimed to assess the immunoexpression of BRAFV600E and KIT in a case series consisting of 44 early-stage melanomas. Formalin-fixed paraffin-embedded samples were systematically evaluated using a semi-quantitative method based on scores of percentage and intensity for immunostained tumor cells. We observed significant concordance between BRAFV600E and KIT immunoexpression in thin invasive melanomas. Our findings corroborate previous evidence showing abnormal expression of proteins associated with MAPK intracellular signaling pathway in early-stage melanomas.

Details

Language :
English
ISSN :
1806-4841
Volume :
94
Issue :
4
Database :
MEDLINE
Journal :
Anais brasileiros de dermatologia
Publication Type :
Academic Journal
Accession number :
31644622
Full Text :
https://doi.org/10.1590/abd1806-4841.20198349