1. Effect of CYP2D6 genetic polymorphism on peak propafenone concentration: no significant effect of CYP2D6*10 .
- Author
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Doki K, Shirayama Y, Sekiguchi Y, Aonuma K, Kohda Y, Ieda M, and Homma M
- Subjects
- Aged, Alleles, Anti-Arrhythmia Agents therapeutic use, Arrhythmias, Cardiac drug therapy, Biotransformation, Female, Genotype, Humans, Male, Middle Aged, Models, Statistical, Polymorphism, Genetic, Propafenone analogs & derivatives, Propafenone blood, Propafenone therapeutic use, Anti-Arrhythmia Agents pharmacokinetics, Cytochrome P-450 CYP2D6 genetics, Propafenone pharmacokinetics
- Abstract
Aim: The study aims to investigate the clinical implication of nonfunctional poor metabolizer (PM) alleles and intermediate metabolizer (IM) alleles of CYP2D6 , including the CYP2D6*10 allele which shows substrate-dependent decrease in enzymatic activity, in antiarrhythmic therapy using propafenone. Materials & methods: We examined serum propafenone concentrations and metabolic ratio, which was expressed as serum concentrations of propafenone to 5-hydroxypropafenone, in 66 Japanese patients with tachyarrhythmias. Results: The peak propafenone concentration and metabolic ratio in CYP2D6 PM allele carriers were higher than those in extensive metabolizer (EM)/EM, EM/IM and IM/IM genotype groups. Conclusion: Results suggest that CYP2D6 PM alleles affect peak propafenone concentration, but the CYP2D6 IM allele CYP2D6*10 has no clinical implication in propafenone dosing.
- Published
- 2020
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