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Lethal suicidal intoxication with propafenone, after a history of self-inflicted injuries.
- Source :
-
Forensic science international [Forensic Sci Int] 1997 Sep 19; Vol. 89 (1-2), pp. 27-32. - Publication Year :
- 1997
-
Abstract
- Report of a suicidal mono-intoxication with the class IC antiarrythmic drug propafenone. A 20-year-old female physician's assistant secretly ingested the substance (presumably 20 tablets per 300 mg) about 4-6 h before her death, and in the interim remained under the supervision of her physician. An ECG taken about 1/2-2 h after ingestion showed widening of the QRS complex and signs of an acute load of the right ventricle; the clinical symptoms were nausea, vomiting and hypotonia. After about 4 h without serious symptoms acute loss of consciousness and cardiac failure occurred, resuscitation efforts remained unsuccessful. At autopsy propafenone was found in blood (12 micrograms ml-1), liver (60 micrograms g-1) and cardiac muscle (11 micrograms g-1).
Details
- Language :
- English
- ISSN :
- 0379-0738
- Volume :
- 89
- Issue :
- 1-2
- Database :
- MEDLINE
- Journal :
- Forensic science international
- Publication Type :
- Academic Journal
- Accession number :
- 9306661
- Full Text :
- https://doi.org/10.1016/s0379-0738(97)00100-x