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241 results on '"Prior, Julie L."'

1. CS1 CAR-T targeting the distal domain of CS1 (SLAMF7) shows efficacy in high tumor burden myeloma model despite fratricide of CD8+CS1 expressing CAR-T cells

Author

O’Neal, Julie, Ritchey, Julie K., Cooper, Matthew L., Niswonger, Jessica, Sofía González, L., Street, Emily, Rettig, Michael P., Gladney, Susan W., Gehrs, Leah, Abboud, Ramzi, Prior, Julie L., Haas, Gabriel J., Jayasinghe, Reyka G., Ding, Li, Ghobadi, Armin, Vij, Ravi, and DiPersio, John F.

Published
2022
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4. Table S3 from Breast Cancer Mutations HER2V777L and PIK3CAH1047R Activate the p21–CDK4/6–Cyclin D1 Axis to Drive Tumorigenesis and Drug Resistance

Author

Cheng, Xiaoqing, primary, Sun, Yirui, primary, Highkin, Maureen, primary, Vemalapally, Nagalaxmi, primary, Jin, Xiaohua, primary, Zhou, Brandon, primary, Prior, Julie L., primary, Tipton, Ashley R., primary, Li, Shunqiang, primary, Iliuk, Anton, primary, Achilefu, Samuel, primary, Hagemann, Ian S., primary, Edwards, John R., primary, and Bose, Ron, primary

Published
2023
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5. Data from Breast Cancer Mutations HER2V777L and PIK3CAH1047R Activate the p21–CDK4/6–Cyclin D1 Axis to Drive Tumorigenesis and Drug Resistance

Author

Cheng, Xiaoqing, primary, Sun, Yirui, primary, Highkin, Maureen, primary, Vemalapally, Nagalaxmi, primary, Jin, Xiaohua, primary, Zhou, Brandon, primary, Prior, Julie L., primary, Tipton, Ashley R., primary, Li, Shunqiang, primary, Iliuk, Anton, primary, Achilefu, Samuel, primary, Hagemann, Ian S., primary, Edwards, John R., primary, and Bose, Ron, primary

Published
2023
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6. Figures S1-S8 from Breast Cancer Mutations HER2V777L and PIK3CAH1047R Activate the p21–CDK4/6–Cyclin D1 Axis to Drive Tumorigenesis and Drug Resistance

Author

Cheng, Xiaoqing, primary, Sun, Yirui, primary, Highkin, Maureen, primary, Vemalapally, Nagalaxmi, primary, Jin, Xiaohua, primary, Zhou, Brandon, primary, Prior, Julie L., primary, Tipton, Ashley R., primary, Li, Shunqiang, primary, Iliuk, Anton, primary, Achilefu, Samuel, primary, Hagemann, Ian S., primary, Edwards, John R., primary, and Bose, Ron, primary

Published
2023
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7. An “off-the-shelf” fratricide-resistant CAR-T for the treatment of T cell hematologic malignancies

Author

Cooper, Matthew L, Choi, Jaebok, Staser, Karl, Ritchey, Julie K, Devenport, Jessica M, Eckardt, Kayla, Rettig, Michael P, Wang, Bing, Eissenberg, Linda G, Ghobadi, Armin, Gehrs, Leah N, Prior, Julie L, Achilefu, Samuel, Miller, Christopher A, Fronick, Catrina C, O’Neal, Julie, Gao, Feng, Weinstock, David M, Gutierrez, Alejandro, Fulton, Robert S, and DiPersio, John F

Published
2018
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8. Breast Cancer Mutations HER2V777L and PIK3CAH1047R Activate the p21–CDK4/6–Cyclin D1 Axis to Drive Tumorigenesis and Drug Resistance

Author

Cheng, Xiaoqing, primary, Sun, Yirui, additional, Highkin, Maureen, additional, Vemalapally, Nagalaxmi, additional, Jin, Xiaohua, additional, Zhou, Brandon, additional, Prior, Julie L., additional, Tipton, Ashley R., additional, Li, Shunqiang, additional, Iliuk, Anton, additional, Achilefu, Samuel, additional, Hagemann, Ian S., additional, Edwards, John R., additional, and Bose, Ron, additional

Published
2023
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10. Abstract 5778: Breast cancer mutations HER2V777L and PIK3CAH1047R activate the p21-CDK4/6 -Cyclin D1 axis driving tumorigenesis and drug resistance

Author

Cheng, Xiaoqing, primary, Sun, Yirui, additional, Highkin, Maureen, additional, Vemalapally, Nagalaxmi, additional, Jin, Xiaohua, additional, Zhou, Brandon, additional, Prior, Julie L., additional, Tipton, Ashley R., additional, Li, Shunqiang, additional, Iliuk, Anton, additional, Achilefu, Samuel, additional, Hagemann, Ian S., additional, Edwards, John, additional, and Bose, Ron, additional

Published
2023
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11. Supplementary Methods from Hedgehog Signaling Inhibition Blocks Growth of Resistant Tumors through Effects on Tumor Microenvironment

Author

Heller, Emanuela, primary, Hurchla, Michelle A., primary, Xiang, Jingyu, primary, Su, Xinming, primary, Chen, Sara, primary, Schneider, Jochen, primary, Joeng, Kyu-Sang, primary, Vidal, Marcos, primary, Goldberg, Leah, primary, Deng, Hongju, primary, Hornick, Mary C., primary, Prior, Julie L., primary, Piwnica-Worms, David, primary, Long, Fanxin, primary, Cagan, Ross, primary, and Weilbaecher, Katherine N., primary

Published
2023
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12. Supplementary Figure 5 from Hedgehog Signaling Inhibition Blocks Growth of Resistant Tumors through Effects on Tumor Microenvironment

Author

Heller, Emanuela, primary, Hurchla, Michelle A., primary, Xiang, Jingyu, primary, Su, Xinming, primary, Chen, Sara, primary, Schneider, Jochen, primary, Joeng, Kyu-Sang, primary, Vidal, Marcos, primary, Goldberg, Leah, primary, Deng, Hongju, primary, Hornick, Mary C., primary, Prior, Julie L., primary, Piwnica-Worms, David, primary, Long, Fanxin, primary, Cagan, Ross, primary, and Weilbaecher, Katherine N., primary

Published
2023
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16. Supplementary Figure 1 from Hedgehog Signaling Inhibition Blocks Growth of Resistant Tumors through Effects on Tumor Microenvironment

Author

Heller, Emanuela, primary, Hurchla, Michelle A., primary, Xiang, Jingyu, primary, Su, Xinming, primary, Chen, Sara, primary, Schneider, Jochen, primary, Joeng, Kyu-Sang, primary, Vidal, Marcos, primary, Goldberg, Leah, primary, Deng, Hongju, primary, Hornick, Mary C., primary, Prior, Julie L., primary, Piwnica-Worms, David, primary, Long, Fanxin, primary, Cagan, Ross, primary, and Weilbaecher, Katherine N., primary

Published
2023
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17. Supplementary Figure Legends 1-5 from Hedgehog Signaling Inhibition Blocks Growth of Resistant Tumors through Effects on Tumor Microenvironment

Author

Heller, Emanuela, primary, Hurchla, Michelle A., primary, Xiang, Jingyu, primary, Su, Xinming, primary, Chen, Sara, primary, Schneider, Jochen, primary, Joeng, Kyu-Sang, primary, Vidal, Marcos, primary, Goldberg, Leah, primary, Deng, Hongju, primary, Hornick, Mary C., primary, Prior, Julie L., primary, Piwnica-Worms, David, primary, Long, Fanxin, primary, Cagan, Ross, primary, and Weilbaecher, Katherine N., primary

Published
2023
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18. Supplementary Figure 2 from Hedgehog Signaling Inhibition Blocks Growth of Resistant Tumors through Effects on Tumor Microenvironment

Author

Heller, Emanuela, primary, Hurchla, Michelle A., primary, Xiang, Jingyu, primary, Su, Xinming, primary, Chen, Sara, primary, Schneider, Jochen, primary, Joeng, Kyu-Sang, primary, Vidal, Marcos, primary, Goldberg, Leah, primary, Deng, Hongju, primary, Hornick, Mary C., primary, Prior, Julie L., primary, Piwnica-Worms, David, primary, Long, Fanxin, primary, Cagan, Ross, primary, and Weilbaecher, Katherine N., primary

Published
2023
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19. Data from Hedgehog Signaling Inhibition Blocks Growth of Resistant Tumors through Effects on Tumor Microenvironment

Author

Heller, Emanuela, primary, Hurchla, Michelle A., primary, Xiang, Jingyu, primary, Su, Xinming, primary, Chen, Sara, primary, Schneider, Jochen, primary, Joeng, Kyu-Sang, primary, Vidal, Marcos, primary, Goldberg, Leah, primary, Deng, Hongju, primary, Hornick, Mary C., primary, Prior, Julie L., primary, Piwnica-Worms, David, primary, Long, Fanxin, primary, Cagan, Ross, primary, and Weilbaecher, Katherine N., primary

Published
2023
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20. Supplementary Figure 4 from Hedgehog Signaling Inhibition Blocks Growth of Resistant Tumors through Effects on Tumor Microenvironment

Author

Heller, Emanuela, primary, Hurchla, Michelle A., primary, Xiang, Jingyu, primary, Su, Xinming, primary, Chen, Sara, primary, Schneider, Jochen, primary, Joeng, Kyu-Sang, primary, Vidal, Marcos, primary, Goldberg, Leah, primary, Deng, Hongju, primary, Hornick, Mary C., primary, Prior, Julie L., primary, Piwnica-Worms, David, primary, Long, Fanxin, primary, Cagan, Ross, primary, and Weilbaecher, Katherine N., primary

Published
2023
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25. Supplementary Figure 3 from Hedgehog Signaling Inhibition Blocks Growth of Resistant Tumors through Effects on Tumor Microenvironment

Author

Heller, Emanuela, primary, Hurchla, Michelle A., primary, Xiang, Jingyu, primary, Su, Xinming, primary, Chen, Sara, primary, Schneider, Jochen, primary, Joeng, Kyu-Sang, primary, Vidal, Marcos, primary, Goldberg, Leah, primary, Deng, Hongju, primary, Hornick, Mary C., primary, Prior, Julie L., primary, Piwnica-Worms, David, primary, Long, Fanxin, primary, Cagan, Ross, primary, and Weilbaecher, Katherine N., primary

Published
2023
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28. Breast cancer mutations HER2V777Land PIK3CAH1047Ractivate the p21-CDK4/6 –Cyclin D1 axis driving tumorigenesis and drug resistance

Author

Cheng, Xiaoqing, primary, Sun, Yirui, additional, Highkin, Maureen, additional, Vemalapally, Nagalaxmi, additional, Jin, Xiaohua, additional, Zhou, Brandon, additional, Prior, Julie L., additional, Tipton, Ashley R., additional, Li, Shunqiang, additional, Iliuk, Anton, additional, Achilefu, Samuel, additional, Hagemann, Ian S., additional, Edwards, John R., additional, and Bose, Ron, additional

Published
2022
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37. Generation of a highly inducible Ga14 [right arrow] Fluc universal reporter mouse for in vivo bioluminescence imaging

Author

Pichler, Andrea, Prior, Julie L., Luker, Gary D., and Piwnica-Worms, David

Subjects
Diagnostic imaging -- Methods, Luciferase -- Properties, Bioluminescence -- Observations, Protein-protein interactions -- Evaluation, Science and technology
Abstract

Full understanding of the functional complexity of the protein interactome requires mapping of biomolecular complexes within the cellular environment over biologically relevant time scales. New approaches to imaging interacting protein partners in vivo will allow the study of functional proteomics of human biology and disease within the context of living animals. Herein, we describe a universal transgenic reporter mouse strain that expresses firefly luciferase (Fluc) under the regulatory control of a concatenated Ga14 promoter ([Tg.sup.G4F(+/-)]). Using an adenovirus to deliver a fused binding-domain-activator chimera (GaI4BD-VP16), induction of bioluminescence in [Tg.sup.G4F(+/-)] tissues of up to 4 orders of magnitude was observed in fibroblasts, liver, respiratory epithelia, muscle, and brain. The [Tg.sup.G4F(+/-)] reporter strain allowed noninvasive detection of viral infectivity, duration of the infection as well as viral clearance in various tissues in vivo. To demonstrate protein-protein interactions in live mice, the well characterized interaction between tumor suppressor p53 (fused to Ga14BD) and large T antigen (TAg) (fused to VP16) was visualized in vivo by using a two-hybrid strategy. Hepatocytes of [Tg.sup.G4F(+/-)] mice transfected with p53/TAg demonstrated 48-fold greater induction of Fluc expression in vivo than noninteracting pairs. Furthermore, to demonstrate the feasibility of monitoring experimental therapy with siRNA in vivo, targeted knockdown of p53 resulted in markedly reduced light output, whereas use of a control siRNA had no effect on protein interaction-dependent induction of Fluc. Thus, this highly inducible Ga14 [right arrow] Fluc conditional reporter strain should facilitate imaging studies of protein interactions, signaling cascades, viral dissemination, and therapy within the physiological context of the whole animal. luciferase | molecular imaging | p53 | protein-protein interactions | transgenic reporter mouse

Published
2008

38. Biochemical and in vivo characterization of a small, membrane-permeant, capase-activable far-red fluorescent peptide for imaging apoptosis

Author

Bullok, Kristin E., Maxwell, Dustin, Kesarwala, Aparna H., Gammon, Seth, Prior, Julie L., Snow, Margaret, Stanley, Sam, and Piwnica-Worms, David

Subjects
Apoptosis -- Research, Abscess -- Research, Cells -- Permeability, Cells -- Research, Biological sciences, Chemistry
Abstract

A novel cell-permeable activable caspase substrate, Tcap[Q.sub.647], was synthesized to detect apoptosis in vivo. The in vivo experiments showed that Tcap[Q.sub.647] was useful in detecting parasite induced apoptosis in human colon zenograft and liver abscess mouse models, thus indicating that Tcap[Q.sub.647] is a sensitive, effective probe to noninvasively observe apoptosis in vivo.

Published
2007

43. Evidence for a plasma membrane-mediated permeability barrier to Tat basic domain in well-differentiated epithelial cells: lack of correlation with heparin sulfate

Author

Violini, Stefania, Sharma, Vijay, Prior, Julie L., Dyszlewski, Mary, and Piwnica-Worms, David

Subjects
Biochemistry -- Research, Plasma membranes -- Physiological aspects, Permeability -- Research, Epithelial cells -- Physiological aspects, Heparin -- Physiological aspects, Sulfates -- Physiological aspects, Peptides -- Physiological aspects, Biological sciences, Chemistry
Abstract

Research has been conducted on the membrane permeation Tat-peptides. Vectorial transport properties of these peptides have been investigated and the results indicate that the presence of the permeation barrier to Tat-peptides in epithelial cells suggests the existence of the cell-specific mechanisms mediating peptides' translocation.

Published
2002

45. Calcium carbonate nanoparticles stimulate tumor metabolic reprogramming and modulate tumor metastasis

Author

Som, Avik, primary, Raliya, Ramesh, additional, Paranandi, Krishna, additional, High, Rachel A, additional, Reed, Nathan, additional, Beeman, Scott C, additional, Brandenburg, Matthew, additional, Sudlow, Gail, additional, Prior, Julie L, additional, Akers, Walter, additional, Mah-Som, Annelise Y, additional, Habimana-Griffin, Lemoyne, additional, Garbow, Joel, additional, Ippolito, Joseph E, additional, Pagel, Mark D, additional, Biswas, Pratim, additional, and Achilefu, Samuel, additional

Published
2019
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46. A new model of multi-visceral and bone metastatic prostate cancer with perivascular niche targeting by a novel endothelial specific adenoviral vector

Author

Lu, Zhi Hong, primary, Kaliberov, Sergey, additional, Sohn, Rebecca E., additional, Kaliberova, Lyudmila, additional, Du, Yingqiu, additional, Prior, Julie L., additional, Leib, Daniel J., additional, Chauchereau, Anne, additional, Sehn, Jennifer K., additional, Curiel, David T., additional, and Arbeit, Jeffrey M., additional

Published
2017
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49. [ 18 F]FHBG PET/CT Imaging of CD34-TK75 Transduced Donor T Cells in Relapsed Allogeneic Stem Cell Transplant Patients: Safety and Feasibility

Author

Eissenberg, Linda G, primary, Rettig, Michael P, additional, Ritchey, Julie K, additional, Prior, Julie L, additional, Schwarz, Sally W, additional, Frye, Jennifer, additional, White, Brian S, additional, Fulton, Robert S, additional, Ghobadi, Armin, additional, Cooper, Matthew L, additional, Couriel, Daniel R, additional, Seegulam, Muhammad Esa, additional, Piwnica-Worms, David, additional, Dehdashti, Farrokh, additional, Cornetta, Kenneth, additional, and DiPersio, John F, additional

Published
2015
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