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Genetic variations in the tumor necrosis factor-[alpha], TNF receptors, interleukin-6 (IL-6) and IL-6 receptor genes predict high-risk status for spontaneous preterm birth in European-American women. Spontaneous preterm birth (sPTB) and low birth weight caused by preterm birth are primary risk factors for infant morbidity and mortality in the US and multiple extrinsic factors like infection, stress, socioeconomic status, nutrition, and behavioral factors are associated with the risk of sPTB.

A study was conducted to determine the association between preterm delivery (PTD), cervical fluid interleukin-6 (IL-6) concentration, and the single nucleotide polymorphism at position -174 in the IL-6 gene. It was concluded that the presence of maternal IL-6 -174C was not associated with cervical fluid concentration of IL-6 or risk of PTD.

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.ajog.2004.05.067 Byline: Josephine H. Amory (a), Kristina M. Adams (a)(b), Ming-Tseh Lin (b), John A. Hansen (b)(c), David A. Eschenbach (a), Jane Hitti (a) Abstract: Two single-base polymorphisms of the tumor necrosis factor-[alpha] gene (TNF-[alpha]) at positions -863 and -308 are associated with variation in production of TNF-[alpha] (TNF-[alpha]). TNF-[alpha] genotypes were tested for association with adverse outcomes in mother-infant pairs with preterm labor. Author Affiliation: (a) Department of Obstetrics and Gynecology (c) and Division of Hematology/Oncology (b) University of Washington, Seattle, Wash, Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, Wash Article History: Received 23 February 2004; Revised 12 May 2004; Accepted 24 May 2004 Article Note: (footnote) Supported by grants No. AI31071, HD01264, AI33484, AI49213, and CA18029 from the National Institutes of Health. Presented at the Twenty-Fourth Annual Meeting of the Society for Maternal-Fetal Medicine, February 2-7, 2004, New Orleans, La. Reprints not available from the authors.

About 13 genes appear to be activated in pregnant mice who develop an infection during labor that are not activated during labor with no infection or infection in non-pregnant mice. This was the conclusion of researchers who used a DNA microarray to analyze the expression of 4,963 genes in pregnant and non-pregnant mice.

2016 MAR 3 (NewsRx) -- By a News Reporter-Staff News Editor at Women's Health Weekly -- Fresh data on Women's Health are presented in a new report. According to news [...]

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.ajog.2010.03.026 Byline: Roberto Romero (a)(b)(c), Digna R. Velez Edwards (e), Juan Pedro Kusanovic (a)(c), Sonia S. Hassan (a)(c), Shali Mazaki-Tovi (a)(c), Edi Vaisbuch (a)(c), Chong Jai Kim (a)(d), Tinnakorn Chaiworapongsa (a)(c), Brad D. Pearce (f), Lara A. Friel (a)(c), Jacquelaine Bartlett (g), Madan Kumar Anant (i), Benjamin A. Salisbury (i), Gerald F. Vovis (j), Min Seob Lee (k), Ricardo Gomez (l)(m), Ernesto Behnke (l), Enrique Oyarzun (m), Gerard Tromp (b), Scott M. Williams (g)(h), Ramkumar Menon (f) Keywords: chorioamnionitis; DNA variants; extracellular matrix; genetic association study; genotype; haplotype; IL-6; parturition; SNP Abstract: The purpose of this study was to determine whether maternal/fetal single nucleotide polymorphisms (SNPs) in candidate genes are associated with spontaneous preterm labor/delivery. Author Affiliation: (a) Perinatology Research Branch, NICHD/NIH/DHHS, Bethesda, MD, and Detroit, MI (b) Center for Molecular Medicine and Genetics, Wayne State University, Detroit, MI (c) Department of Obstetrics and Gynecology, Wayne State University, Detroit, MI (d) Department of Pathology, Wayne State University, Detroit, MI (e) Vanderbilt Epidemiology Center, Institute of Medicine and Public Health, Department of Obstetrics and Gynecology, Vanderbilt University, Nashville, TN (f) Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA (g) Center for Human Genetics Research, Vanderbilt University, Nashville, TN (h) Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN (i) PGxHealth, LLC, New Haven, CT (j) Helix Therapeutics, LLC, New Haven, CT (k) Genaissance Pharmaceuticals, Inc, New Haven, CT (l) Center for Perinatal Diagnosis and Research, Department of Obstetrics and Gynecology, Sotero del Rio Hospital, Santiago, Chile (m) Department of Obstetrics and Gynecology, Pontificia Universidad Catolica de Chile, Santiago, Chile Article History: Received 7 January 2010; Revised 31 January 2010; Accepted 15 March 2010 Article Note: (footnote) Cite this article as: Romero R, Velez Edwards DR, Kusanovic JP, et al. Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes. Am J Obstet Gynecol 2010;202:431.e1-34. , The racing flag logo above indicates that this article was rushed to press for the benefit of the scientific community., Supported in part by the Perinatology Research Branch, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, DHHS. Drs Anant, Salisbury, and Vovis were formerly of Genaissance Pharmaceuticals, Inc., New Haven, CT, where contributions to this work were initiated.

2002 DEC 19 - (NewsRx.com & NewsRx.net) -- A recent study, conducted by researchers in New Zealand, aimed "to identify the novel or differential expression of growth- or development-associated genes [...]