Multilocus interactions at maternal tumor necrosis factor-[alpha], tumor necrosis factor receptors, interleukin-6 and interleukin-6 receptor genes predict spontaneous preterm labor in European-American women

Genetic variations in the tumor necrosis factor-[alpha], TNF receptors, interleukin-6 (IL-6) and IL-6 receptor genes predict high-risk status for spontaneous preterm birth in European-American women. Spontaneous preterm birth (sPTB) and low birth weight caused by preterm birth are primary risk factors for infant morbidity and mortality in the US and multiple extrinsic factors like infection, stress, socioeconomic status, nutrition, and behavioral factors are associated with the risk of sPTB.