Search

Shows that the VHS domain of the GGA2 protein family binds to the acidic cluster-dileucine motif in the cytoplasmic tail of the cation-independent mannose 6-phosphate receptor (CI-MPR). Defects of receptors with mutations in the motif in lysosomal enzyme sorting; Hinge domain of GGA2 bound clathrin; Importance for lysosomal enzyme targeting.

New laser methods have introduced new possibilities and partly replaced traditional methods in corneal surgery. Femtosecond lasers have traditionally been used to replace the surgeons' knife in corneal refractive surgery and corneal transplantation. Excimer laser has been used from the beginning of 1990 for the reshaping of cornea. With the development of excimer laser, traditional photorefractive corneal surgery has improved and new methods have been found such as PRK, PTK, epi-LASIK, and LASEK. Today LASIK, the most commonly used refractive surgery, uses both femtosecond and excimer lasers. SMILE, the most recent method in corneal refractive surgery, is solely based on the use of femtosecond laser.