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While Yoda1 treatment alone reduced the contractions of the myometrium to 17% of interested control, competitive inhibition by Dooku1 rescued oxytocin-induced contractions to 90%, indicating a direct effect of PIEZO1 activation in relaxation of human myometrium. Keywords: cardiovascular; PIEZO1; preterm birth; preterm labour EN cardiovascular PIEZO1 preterm birth preterm labour 719 721 3 02/17/23 20230215 NES 230215 During pregnancy, the uterus undergoes significant distention to accommodate the growing fetus. [Extracted from the article]

Therefore, it is likely that insulin binds neuronal insulin receptors and triggers signalling pathways, intermediate molecules of which sensitize and/or activate nociceptive channels. Insulin binding to the insulin receptor activates the phosphoinositide 3-kinase (PI3K) pathway. Together, these observations indicate that insulin activates insulin receptor signalling by inducing the activation of PI3K, PKC enzymes which phosphorylate and sensitize the nociceptive ion channels towards a lower mechanical stimulus (Figure). [Extracted from the article]

During atherosclerosis plaque progression, pathological intraplaque angiogenesis leads to plaque rupture accompanied by thrombosis, which is probably the most important cause of arteries complications such as cerebral and myocardial infarction. Even though few treatments are available to mitigate plaque rupture, further investigation is required to develop a robust optimized therapeutic method. In this study using rabbit and mouse atherosclerotic models, sinoporphyrin sodium (DVDMS)-mediated sonodynamic therapy reduced abnormal angiogenesis and plaque rupture. Briefly, DVDMS is injected to animals, and then the plaque was locally exposed to pulse ultrasound for a few minutes. Furthermore, a small size clinical trial was conducted on patients with atherosclerosis. Notably, a significant reduction of arterial inflammation and angiogenesis was recorded following a short period of DVDMS-mediated sonodynamic therapy treatment. This beneficial outcome was almost equivalent to the therapeutic outcome after 3-month intensive statin treatment., (© 2020 The Authors.)