Piezo1 activation by stretching of uterine myometrium supports pregnancy and prevents preterm labour.

While Yoda1 treatment alone reduced the contractions of the myometrium to 17% of interested control, competitive inhibition by Dooku1 rescued oxytocin-induced contractions to 90%, indicating a direct effect of PIEZO1 activation in relaxation of human myometrium. Keywords: cardiovascular; PIEZO1; preterm birth; preterm labour EN cardiovascular PIEZO1 preterm birth preterm labour 719 721 3 02/17/23 20230215 NES 230215 During pregnancy, the uterus undergoes significant distention to accommodate the growing fetus. [Extracted from the article]