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770 results on '"Poon, Ronnie T"'

1. Supplementary Table 1 from Circulating Oncometabolite 2-Hydroxyglutarate Is a Potential Surrogate Biomarker in Patients with Isocitrate Dehydrogenase-Mutant Intrahepatic Cholangiocarcinoma

Author

Borger, Darrell R., primary, Goyal, Lipika, primary, Yau, Thomas, primary, Poon, Ronnie T., primary, Ancukiewicz, Marek, primary, Deshpande, Vikram, primary, Christiani, David C., primary, Liebman, Hannah M., primary, Yang, Hua, primary, Kim, Hyeryun, primary, Yen, Katharine, primary, Faris, Jason E., primary, Iafrate, A. John, primary, Kwak, Eunice L., primary, Clark, Jeffrey W., primary, Allen, Jill N., primary, Blaszkowsky, Lawrence S., primary, Murphy, Janet E., primary, Saha, Supriya K., primary, Hong, Theodore S., primary, Wo, Jennifer Y., primary, Ferrone, Cristina R., primary, Tanabe, Kenneth K., primary, Bardeesy, Nabeel, primary, Straley, Kimberly S., primary, Agresta, Sam, primary, Schenkein, David P., primary, Ellisen, Leif W., primary, Ryan, David P., primary, and Zhu, Andrew X., primary

Published
2023
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2. Supplementary Table 3 from Circulating Oncometabolite 2-Hydroxyglutarate Is a Potential Surrogate Biomarker in Patients with Isocitrate Dehydrogenase-Mutant Intrahepatic Cholangiocarcinoma

Author

Borger, Darrell R., primary, Goyal, Lipika, primary, Yau, Thomas, primary, Poon, Ronnie T., primary, Ancukiewicz, Marek, primary, Deshpande, Vikram, primary, Christiani, David C., primary, Liebman, Hannah M., primary, Yang, Hua, primary, Kim, Hyeryun, primary, Yen, Katharine, primary, Faris, Jason E., primary, Iafrate, A. John, primary, Kwak, Eunice L., primary, Clark, Jeffrey W., primary, Allen, Jill N., primary, Blaszkowsky, Lawrence S., primary, Murphy, Janet E., primary, Saha, Supriya K., primary, Hong, Theodore S., primary, Wo, Jennifer Y., primary, Ferrone, Cristina R., primary, Tanabe, Kenneth K., primary, Bardeesy, Nabeel, primary, Straley, Kimberly S., primary, Agresta, Sam, primary, Schenkein, David P., primary, Ellisen, Leif W., primary, Ryan, David P., primary, and Zhu, Andrew X., primary

Published
2023
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3. Supplementary Table 2 from Circulating Oncometabolite 2-Hydroxyglutarate Is a Potential Surrogate Biomarker in Patients with Isocitrate Dehydrogenase-Mutant Intrahepatic Cholangiocarcinoma

Author

Borger, Darrell R., primary, Goyal, Lipika, primary, Yau, Thomas, primary, Poon, Ronnie T., primary, Ancukiewicz, Marek, primary, Deshpande, Vikram, primary, Christiani, David C., primary, Liebman, Hannah M., primary, Yang, Hua, primary, Kim, Hyeryun, primary, Yen, Katharine, primary, Faris, Jason E., primary, Iafrate, A. John, primary, Kwak, Eunice L., primary, Clark, Jeffrey W., primary, Allen, Jill N., primary, Blaszkowsky, Lawrence S., primary, Murphy, Janet E., primary, Saha, Supriya K., primary, Hong, Theodore S., primary, Wo, Jennifer Y., primary, Ferrone, Cristina R., primary, Tanabe, Kenneth K., primary, Bardeesy, Nabeel, primary, Straley, Kimberly S., primary, Agresta, Sam, primary, Schenkein, David P., primary, Ellisen, Leif W., primary, Ryan, David P., primary, and Zhu, Andrew X., primary

Published
2023
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4. Adjuvant sorafenib for hepatocellular carcinoma after resection or ablation (STORM): a phase 3, randomised, double-blind, placebo-controlled trial

Author

Bruix, Jordi, Takayama, Tadatoshi, Mazzaferro, Vincenzo, Chau, Gar-Yang, Yang, Jiamei, Kudo, Masatoshi, Cai, Jianqiang, Poon, Ronnie T, Han, Kwang-Hyub, Tak, Won Young, Lee, Han Chu, Song, Tianqiang, Roayaie, Sasan, Bolondi, Luigi, Lee, Kwan Sik, Makuuchi, Masatoshi, Souza, Fabricio, Berre, Marie-Aude Le, Meinhardt, Gerold, and Llovet, Josep M

Published
2015
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30. Improved Long-Term Survival after Major Resection for Hepatocellular Carcinoma: A Multicenter Analysis Based on a New Definition of Major Hepatectomy

Author

Andreou, Andreas, Vauthey, Jean-Nicolas, Cherqui, Daniel, Zimmitti, Giuseppe, Ribero, Dario, Truty, Mark J., Wei, Steven H., Curley, Steven A., Laurent, Alexis, Poon, Ronnie T., Belghiti, Jacques, Nagorney, David M., Aloia, Thomas A., and From the International Cooperative Study Group on Hepatocellular Carcinoma

Published
2013
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36. An N-terminal truncated carboxypeptidase E splice isoform induces tumor growth and is a biomarker for predicting future metastasis in human cancers

Author

Lee, Terence K., Murthy, Saravana R.K., Cawley, Niamh X., Dhanvantari, Savita, Hewitt, Stephen M., Lou, Hong, Lau, Tracy, Ma, Stephanie, Huynh, Thanh, Wesley, Robert A., Ng, Irene O., Pacak, Karel, Poon, Ronnie T., and Loh, Y. Peng

Subjects
Tumors -- Health aspects -- Growth -- Genetic aspects -- Research, Gene expression -- Research, Proteases -- Physiological aspects -- Research, Biological markers -- Physiological aspects -- Research, Company growth, Health care industry
Abstract

Metastasis is a major cause of mortality in cancer patients. However, the mechanisms governing the metastatic process remain elusive, and few accurate biomarkers exist for predicting whether metastasis will occur, something that would be invaluable for guiding therapy. We report here that the carboxypeptidase E gene (CPE) is alternatively spliced in human tumors to yield an N-terminal truncated protein (CPE-ΔN) that drives metastasis. mRNA encoding CPE-ΔN was found to be elevated in human metastatic colon, breast, and hepatocellular carcinoma (HCC) cell lines. In HCC cells, cytosolic CPE-ΔN was translocated to the nucleus and interacted with histone deacetylase 1/2 to upregulate expression of the gene encoding neural precursor cell expressed, developmentally downregulated gene 9 (Nedd9)--which has been shown to promote melanoma metastasis. Nedd9 upregulation resulted in enhanced in vitro proliferation and invasion. Quantification of mRNA encoding CPE-ΔN in HCC patient samples predicted intrahepatic metastasis with high sensitivity and specificity, independent of cancer stage. Similarly, high CPE-ΔN mRNA copy numbers in resected pheochromocytomas/paragangliomas (PHEOs/PGLs), rare neuroendocrine tumors, accurately predicted future metastasis or recurrence. Thus, CPE-ΔN induces tumor metastasis and should be investigated as a potentially powerful biomarker for predicting future metastasis and recurrence in HCC and PHEO/PGL patients., Introduction Cancer mortality often results from metastatic disease and is not the direct effect of the primary tumor. With advances in cancer treatment, control of the primary tumor can be [...]

Published
2011
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39. Asian Pacific Association for the Study of the Liver consensus recommendations on hepatocellular carcinoma

Author

Omata, Masao, Lesmana, Laurentius A., Tateishi, Ryosuke, Chen, Pei-Jer, Lin, Shi-Ming, Yoshida, Haruhiko, Kudo, Masatoshi, Lee, Jeong Min, Choi, Byung Ihn, Poon, Ronnie T. P., Shiina, Shuichiro, Cheng, Ann Lii, Jia, Ji-Dong, Obi, Shuntaro, Han, Kwang Hyub, Jafri, Wasim, Chow, Pierce, Lim, Seng Gee, Chawla, Yogesh K., Budihusodo, Unggul, Gani, Rino A., Lesmana, C. Rinaldi, Putranto, Terawan Agus, Liaw, Yun Fan, and Sarin, Shiv Kumar

Published
2010
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44. Effect of Everolimus on Survival in Advanced Hepatocellular Carcinoma After Failure of Sorafenib: The EVOLVE-1 Randomized Clinical Trial

Author

Zhu, Andrew X., Kudo, Masatoshi, Assenat, Eric, Cattan, Stéphane, Kang, Yoon-Koo, Lim, Ho Yeong, Poon, Ronnie T. P., Blanc, Jean-Frederic, Vogel, Arndt, Chen, Chao-Long, Dorval, Etienne, Peck-Radosavljevic, Markus, Santoro, Armando, Daniele, Bruno, Furuse, Junji, Jappe, Annette, Perraud, Kevin, Anak, Oezlem, Sellami, Dalila B., and Chen, Li-Tzong

Published
2014
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