1. The Synthesis and Antiviral Activity of Glycyrrhizic Acid Conjugates with α-D-Glucosamine and Some Glycosylamines
- Author
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R Pompei, A G Pokrovskiĭ, S. R. Mustafina, E. V. Vasil'eva, D Deidda, Baltina Lidiya A, Tolstikov Genrikh A, R. M. Kondratenko, and Pliasunova Oa
- Subjects
chemistry.chemical_classification ,Glucosamine ,Glycoconjugate ,Stereochemistry ,Organic Chemistry ,Conjugated system ,Carbohydrate ,Glycyrrhizic Acid ,Antiviral Agents ,Biochemistry ,carbohydrates (lipids) ,chemistry ,Chlorocebus aethiops ,Vero cell ,Animals ,Simplexvirus ,Bioorganic chemistry ,Molecule ,Amine gas treating ,Glycoconjugates ,Vero Cells ,Cells, Cultured ,Conjugate - Abstract
Glycyrrhizic acid and its 30-methyl ester were conjugated with 2-amino-1,3,4,6-tetra-O-acetyl-2-deoxy-alpha-D-glucopyranose, 2,3,4,6-tetra-O-acetyl-beta-D-glucopyranosyl amine, 2,3,4-tri-O-acetyl-apha-L-arabinopyranosyl amine, 2-acetamido-2-deoxy-beta-D-glucopyranosyl amine, and beta-D-galactopyranosyl amine using N,N'-dicyclohexylcarbodiimide and its mixtures with N-hydroxybenzotriazole. Structures of the conjugates were confirmed by IR, UV, 1H, and 13C NMR spectroscopy. The glycoconjugate with the residues of 2-acetamido-2-deoxy-beta-D-glucopyranosyl amine in the carbohydrate part of its molecule exhibited antiviral activity (ID50 4 microg/ml) toward the herpes simplex type 1 virus (HSV-1) in the VERO cell culture. Two compounds demonstrated anti-HIV-1 activity (50-70% inhibition of p24) in a culture of MT-4 cells at concentrations of 0.5-20 microg/ml. The English version of the paper: Russian Journal of Bioorganic Chemistry, 2004, vol. 30, no. 3; see also http://www.maik.ru.
- Published
- 2004