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[Synthesis and pharmacological activity of betulin dinicotinate].
- Source :
-
Bioorganicheskaia khimiia [Bioorg Khim] 2002 Nov-Dec; Vol. 28 (6), pp. 543-50. - Publication Year :
- 2002
-
Abstract
- The assignment of NMR resonances of lupane triterpenoids was refined by the example of 3,28-dinicotinoylbetulin, obtained by acylation of betulin. Hepatoprotective, untiulcer, antiinflammatory, reparative, and anti-HIV activities were found for the compound. In addition, it was demonstrated to have immunomodulatory activity, for the first time detected among lupane triterpenoids. The English version of the paper: Russian Journal of Bioorganic Chemistry, 2002, vol. 28, no. 6; see also http://www.maik.ru.
- Subjects :
- Adjuvants, Immunologic therapeutic use
Adjuvants, Immunologic toxicity
Animals
Anti-HIV Agents therapeutic use
Anti-HIV Agents toxicity
Anti-Inflammatory Agents, Non-Steroidal therapeutic use
Anti-Inflammatory Agents, Non-Steroidal toxicity
Antibody Formation drug effects
Arthritis drug therapy
Betula chemistry
Burns drug therapy
Cell Line
Cell Survival drug effects
Disease Models, Animal
Dose-Response Relationship, Drug
HIV Core Protein p24 analysis
HIV-1 drug effects
Humans
Lethal Dose 50
Mice
Plant Bark chemistry
Rats
Stomach Ulcer drug therapy
Triterpenes chemistry
Triterpenes isolation & purification
Triterpenes therapeutic use
Triterpenes toxicity
Adjuvants, Immunologic chemical synthesis
Anti-HIV Agents chemical synthesis
Anti-Inflammatory Agents, Non-Steroidal chemical synthesis
Triterpenes chemical synthesis
Subjects
Details
- Language :
- Russian
- ISSN :
- 0132-3423
- Volume :
- 28
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Bioorganicheskaia khimiia
- Publication Type :
- Academic Journal
- Accession number :
- 12528466
- Full Text :
- https://doi.org/10.1023/a:1021297600187