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20 maart 2023, Item does not contain fulltext, In recent years an increasing number of cultural products have come under fire for moral or political reasons, such as racist or sexist content, in the mainstream (White) public sphere. An outstanding example is the classic 1939 film Gone with the Wind (GWTW), which is loved by many but also strongly criticised for glorifying the American Antebellum South and ignoring the inhumanity of slavery. This case study explores how fans of the film (and the novel on which it was based) negotiate their appreciation of GWTW and these controversial issues. Using an open-ended survey and follow-up interviews, we explore two dominant narratives among the film's predominantly White fans: one that fiercely defends the film against criticism and one that expresses increased feelings of ambivalence and awkwardness. Thus, we add a more self-reflective and dynamic approach to scholarship on cultural taste, audience reception, and fan studies.

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Contains fulltext : 299418.pdf (Publisher’s version ) (Open Access)

Contains fulltext : 299416.pdf (Publisher’s version ) (Open Access)

Contains fulltext : upload_in_progress_2066_294511.pdf (Publisher’s version ) (Closed access), While the so-called material turn in the humanities and the social sciences has inspired a vibrant discourse on objects, things, and the concept of materiality in general, less attention has been paid to materials, particularly in cultural studies scholarship. With each of its chapters taking a particular material as its point of departure, this volume offers a palette of fresh approaches to materials within the realm of cultural studies. The contributors call for a materials-based perspective on culture, which has become all the more pertinent in times of climate change, energy crisis, conflict, migration, and the lingering coronavirus pandemic., 270 p.

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Radboud University, 20 april 2022, Promotores : Smelik, A.M., Plate, L., Contains fulltext : 249053.pdf (Publisher’s version ) (Closed access)

Contains fulltext : 252785.pdf (Publisher’s version ) (Open Access)

Recessive gene mutations underlie many developmental disorders and often lead to disabling neurological problems. Here, we report identification of a homozygous c.170G>A (p.Cys57Tyr or C57Y) mutation in the gene coding for protein disulfide isomerase A3 (PDIA3, also known as ERp57), an enzyme that catalyzes formation of disulfide bonds in the endoplasmic reticulum, to be associated with syndromic intellectual disability. Experiments in zebrafish embryos show that PDIA3C57Y expression is pathogenic and causes developmental defects such as axonal disorganization as well as skeletal abnormalities. Expression of PDIA3C57Y in the mouse hippocampus results in impaired synaptic plasticity and memory consolidation. Proteomic and functional analyses reveal that PDIA3C57Y expression leads to dysregulation of cell adhesion and actin cytoskeleton dynamics, associated with altered integrin biogenesis and reduced neuritogenesis. Biochemical studies show that PDIA3C57Y has decreased catalytic activity and forms disulfide-crosslinked aggregates that abnormally interact with chaperones in the endoplasmic reticulum. Thus, rare disease gene variant can provide insight into how perturbations of neuronal proteostasis can affect the function of the nervous system.

Radboud University, 19 oktober 2021, Promotores : Plate, L., Smelik, A.M., Contains fulltext : 239427.pdf (Publisher’s version ) (Open Access)

25 maart 2021, Contains fulltext : 231858.pdf (Publisher’s version ) (Open Access)

Item does not contain fulltext, New materialism (and new materialisms) is part of the material turn currently sweeping through the Humanities and Social Sciences and entails a paradigm shift towards a more material(ist) understanding of social and cultural life. From new materialist thinking, new (empirical) approaches, methods, methodologies and objects of study ensue. The new materialisms emerge from feminism, philosophy and science and technologies studies and critique the foundational binaries of modern thought, especially the nature/culture, object/subject, human/thing dualisms, whose anthropocentric biases are seen to have led to the current ecological and civilizational crisis and the incapacity to think through and adequately engage with them. Proposing to give things their due, new materialisms are interested in “the force of things” and debate “the agency of things.” The post-anthropocentric interest in the vitality of things parallels the non-dualist modes of thinking of Indigenous ontologies on which some new materialisms may in fact be based, but whose influence has so far insufficiently been acknowledged. At its most radical, new materialism is posthumanist, part of the nonhuman turn. A number of scholars have sought to bring the insights and concerns of new materialism(s) into the fields of literary theory and criticism, developing “thing” or “stuff” theory, and seeking to conceptualize and operationalize a new literary materialism. For this, they draw on insights from a range of disciplines, including material culture studies, book and print culture studies, and comparative textual media studies. Given the importance attached to the linguistic turn as the cultural moment and textual approach in relation to which new materialists agonistically construct the newness of their material(ist) endeavors, the publication context of Roland Barthes’s famous essay “The Death of the Author”—the multimedia magazine in a box Aspen 5+6—is highlighted as an important site for critiquing a non-mate

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Rede uitgesproken bij de aanvaarding van het ambt van hoogleraar Cultuur en Inclusiviteit aan de Faculteit der Letteren van de Radboud Universiteit op vrijdag 14 december 2018, 14 december 2018, Inaugural lecture, Contains fulltext : 198822pub.pdf (publisher's version ) (Open Access)

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