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2. The role of antibody responses against glycans in bioprosthetic heart valve calcification and deterioration

Author

Senage, Thomas, Paul, Anu, Le Tourneau, Thierry, Fellah-Hebia, Imen, Vadori, Marta, Bashir, Salam, Galiñanes, Manuel, Bottio, Tomaso, Gerosa, Gino, Evangelista, Arturo, Badano, Luigi P, Nassi, Alberto, Costa, Cristina, Cesare, Galli, Manji, Rizwan A, Cueff de Monchy, Caroline, Piriou, Nicolas, Capoulade, Romain, Serfaty, Jean-Michel, Guimbretière, Guillaume, Dantan, Etienne, Ruiz-Majoral, Alejandro, Coste du Fou, Guénola, Leviatan Ben-Arye, Shani, Govani, Liana, Yehuda, Sharon, Bachar Abramovitch, Shirley, Amon, Ron, Reuven, Eliran Moshe, Atiya-Nasagi, Yafit, Yu, Hai, Iop, Laura, Casós, Kelly, Kuguel, Sebastián G, Blasco-Lucas, Arnau, Permanyer, Eduard, Sbraga, Fabrizio, Llatjós, Roger, Moreno-Gonzalez, Gabriel, Sánchez-Martínez, Melchor, Breimer, Michael E, Holgersson, Jan, Teneberg, Susann, Pascual-Gilabert, Marta, Nonell-Canals, Alfons, Takeuchi, Yasuhiro, Chen, Xi, Mañez, Rafael, Roussel, Jean-Christian, Soulillou, Jean-Paul, Cozzi, Emanuele, and Padler-Karavani, Vered

Subjects
Biomedical and Clinical Sciences, Immunology, Heart Disease, Cardiovascular, 5.3 Medical devices, Development of treatments and therapeutic interventions, Animals, Antibody Formation, Aortic Valve, Aortic Valve Stenosis, Bioprosthesis, Calcinosis, Galactose, Humans, Immunoglobulin G, Mice, Polysaccharides, Prospective Studies, Medical and Health Sciences, Biomedical and clinical sciences, Health sciences
Abstract

Bioprosthetic heart valves (BHVs) are commonly used to replace severely diseased heart valves but their susceptibility to structural valve degeneration (SVD) limits their use in young patients. We hypothesized that antibodies against immunogenic glycans present on BHVs, particularly antibodies against the xenoantigens galactose-α1,3-galactose (αGal) and N-glycolylneuraminic acid (Neu5Gc), could mediate their deterioration through calcification. We established a large longitudinal prospective international cohort of patients (n = 1668, 34 ± 43 months of follow-up (0.1-182); 4,998 blood samples) to investigate the hemodynamics and immune responses associated with BHVs up to 15 years after aortic valve replacement. Early signs of SVD appeared in

Published
2022

4. Machine Learning–Based Phenogrouping in MVP Identifies Profiles Associated With Myocardial Fibrosis and Cardiovascular Events

Author

Huttin, Olivier, Girerd, Nicolas, Jobbe-Duval, Antoine, Constant Dit Beaufils, Anne-Laure, Senage, Thomas, Filippetti, Laura, Cueff, Caroline, Duarte, Kevin, Fraix, Antoine, Piriou, Nicolas, Mandry, Damien, Pace, Nathalie, Le Scouarnec, Solena, Capoulade, Romain, Echivard, Matthieu, Sellal, Jean Marc, Marrec, Marie, Beaumont, Marine, Hossu, Gabriella, Trochu, Jean-Noel, Sadoul, Nicolas, Marie, Pierre-Yves, Guenancia, Charles, Schott, Jean-Jacques, Roussel, Jean-Christian, Serfaty, Jean-Michel, Selton-Suty, Christine, and Le Tourneau, Thierry

Published
2023
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6. Coronary artery disease and revascularization associated with immune checkpoint blocker myocarditis: Report from an international registry

Author

Aghel, Nazanin, Alexandre, Joachim, Aonuma, Kazutaka, Asnani, Aarti H., Behling, Juliane, Bilen, Mehmet, Bottinor, Wendy, Cariou, Eve, Chahine, Johnny, Chan, Weiting, Chauhan, Aman, Cohen, Max, Crusz, Shanthini, Fernando, Suran, Florido, Roberta, Frigeri, Mauro, Fukushima, Satoshi, Gaughan, Elizabeth, Geisler, Benjamin P., Gilstrap, Lauren, Grohe, Christian, Guha, Avirup, Habib, Manhal, Haegler-Laube, Eva, Haydon, Andrew, Hayek, Salim, Hughes, Andrew, Imai, Rysk, Katsume, Yumi, Kimura, Hideki, Koo Lin, Lily, Lenneman, Carrie, Leong, Daryl, Makker, Vicky, Martinez-Calle, Nicolas, Moey, Melissa, Mohri, Masahiro, Morimoto, Ryota, Moritoki, Yoshinobu, Narezkina, Anna, Nicol, Martin, Nooka, Ajay, Orimoloye, Olusola, Patel, Milan, Perl, Michal, Piriou, Nicolas, Raikhelkar, Jayant K., Raza, Yasmin, Rao, Anjali, Reddy, Sunil, Seki, Nobuhiko, Stangl, Karl, Stewart, Andrew, Stringer, Bryan, Tamarappoo, Balaji K., Tamura, Yuichi, Thuny, Frank, Tierney, Sean, Tresorier, Romain, Ullah, Waqas, Von Hunolstein, Jean-Jacques, Warner, Ellen, Weppler, Allison, Nowatzke, Joseph, Guedeney, Paul, Palaskas, Nicholas, Lehmann, Lorenz, Ederhy, Stephane, Zhu, Han, Cautela, Jennifer, Francis, Sanjeev, Courand, Pierre-Yves, Deswal, Anita, Ewer, Steven M., Aras, Mandar, Arangalage, Dimitri, Ghafourian, Kambiz, Fenioux, Charlotte, Finke, Daniel, Peretto, Giovanni, Zaha, Vlad, Itzhaki Ben Zadok, Osnat, Tajiri, Kazuko, Akhter, Nausheen, Levenson, Joshua, Baldassarre, Lauren, Power, John, Huang, Shi, Collet, Jean-Philippe, Moslehi, Javid, and Salem, Joe-Elie

Published
2022
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7. Outcome and Morphofunctional Changes on Cardiac Magnetic Resonance in Patients With Acute Myocarditis Following mRNA COVID-19 Vaccination

Author

Ammirati, Enrico, Lupi, Laura, Palazzini, Matteo, Ciabatti, Michele, Rossi, Valentina A., Gentile, Piero, Uribarri, Aitor, Vecchio, Chiara R., Nassiacos, Daniele, Cereda, Alberto, Conca, Cristina, Tumminello, Gabriele, Piriou, Nicolas, Lelarge, Coline, Pedrotti, Patrizia, Stucchi, Miriam, Peretto, Giovanni, Galasso, Michele, Huang, Florent, Ianni, Umberto, Procopio, Antonio, Saponara, Gianluigi, Cimaglia, Paolo, Tomasoni, Daniela, Moroni, Francesco, Turco, Annalisa, Sala, Simone, Di Tano, Giuseppe, Bollano, Entela, Moro, Claudio, Abbate, Antonio, Della Bona, Roberta, Porto, Italo, Carugo, Stefano, Campodonico, Jeness, Pontone, Gianluca, Grosu, Aurelia, Bolognese, Leonardo, Salamanca, Jorge, Diez-Villanueva, Pablo, Ozieranski, Krzysztof, Tyminska, Agata, Sardo Infirri, Loren, Bromage, Daniel, Cannatà, Antonio, Hong, Kimberly N., Adamo, Marianna, Quattrocchi, Giuseppina, Foà, Alberto, Potena, Luciano, Garascia, Andrea, Giannattasio, Cristina, Adler, Eric D., Sinagra, Gianfranco, Ruschitzka, Frank, Camici, Paolo G., Metra, Marco, and Pieroni, Maurizio

Published
2023
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8. Acute Myocarditis Associated With Desmosomal Gene Variants

Author

Ammirati, Enrico, Raimondi, Francesca, Piriou, Nicolas, Sardo Infirri, Loren, Mohiddin, Saidi A., Mazzanti, Andrea, Shenoy, Chetan, Cavallari, Ugo A., Imazio, Massimo, Aquaro, Giovanni Donato, Olivotto, Iacopo, Pedrotti, Patrizia, Sekhri, Neha, Van de Heyning, Caroline M., Broeckx, Glenn, Peretto, Giovanni, Guttmann, Oliver, Dellegrottaglie, Santo, Scatteia, Alessandra, Gentile, Piero, Merlo, Marco, Goldberg, Randal I., Reyentovich, Alex, Sciamanna, Christopher, Klaassen, Sabine, Poller, Wolfgang, Trankle, Cory R., Abbate, Antonio, Keren, Andre, Horowitz-Cederboim, Smadar, Cadrin-Tourigny, Julia, Tadros, Rafik, Annoni, Giuseppe A., Bonoldi, Emanuela, Toquet, Claire, Marteau, Lara, Probst, Vincent, Trochu, Jean Noël, Kissopoulou, Antheia, Grosu, Aurelia, Kukavica, Deni, Trancuccio, Alessandro, Gil, Cristina, Tini, Giacomo, Pedrazzini, Matteo, Torchio, Margherita, Sinagra, Gianfranco, Gimeno, Juan Ramón, Bernasconi, Davide, Valsecchi, Maria Grazia, Klingel, Karin, Adler, Eric D., Camici, Paolo G., and Cooper, Leslie T., Jr.

Published
2022
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9. Cardiomuscular Biomarkers in the Diagnosis and Prognostication of Immune Checkpoint Inhibitor Myocarditis

Author

Lehmann, Lorenz H., Heckmann, Markus B., Bailly, Guillaume, Finke, Daniel, Procureur, Adrien, Power, John R., Stein, Frederic, Bretagne, Marie, Ederhy, Stephane, Fenioux, Charlotte, Hamwy, Omar, Funck-Brentano, Elisa, Romano, Emanuela, Pieroni, Laurence, Münster, Jan P., Allenbach, Yves, Anquetil, Céline, Leonard-Louis, Sarah, Palaskas, Nicolas L., Hayek, Salim S., Katus, Hugo A., Giannitsis, Evangelos, Frey, Norbert, Kaya, Ziya, Moslehi, Javid, Prifti, Edi, Salem, Joe-Elie, Thuny, Franck, Crusz, Shanthini, Asnani, Aarti, Karlstaedt, Anja, Rocher, Fanny, Paven, Elise, Obeid, Michel, Chan, Wei Ting, Flint, Danette L, Arangalage, Dimitri, Courand, Pierre-Yves, Nicol, Martin, Cariou, Eve, Tamura, Yuichi, Florido, Roberta, Francis, Sanjeev, Leong, Darryl, Piriou, Nicolas, Akhter, Nausheen, Shahneen, Sandhu, Itzhaki Ben Zadok, Osnat, Habib, Manhal, Vachhani, Pankit, Peretto, Giovanni, Zhu, Han, Laufer Perl, Michal, Aras, Mandar, Alexandre, Joachim, Lenneman, Carrie, Levenson, Joshua, Deswal, Anita, Zaha, Vlad G., Gaughan, Elizabeth M, Ewer, Steven, Johnson, Douglas, and Baldassarre, Lauren A

Published
2023
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10. Two-Year Outcomes for Tricuspid Repair With a Transcatheter Edge-to-Edge Valve Repair From the Transatlantic TRILUMINATE Trial

Author

von Bardeleben, Ralph Stephan, Lurz, Philipp, Sorajja, Paul, Ruf, Tobias, Hausleiter, Jörg, Sitges, Marta, Da Rocha e Silva, Jaqueline, Näbauer, Michael, Weber, Marcel, Tang, Gilbert H.L., Heitkemper, Megan, Ying, Shih-Wa, Trochu, Jean-Noel, Kar, Saibal, Hahn, Rebecca T., Nickenig, Georg, Nickenig, Georg, von Bardeleben, Ralph Stephan, Geyer, Martin, Wenaweser, Peter, Biaggi, Patric, Kapos, Ioannis, Alsidawi, Said, Lurz, Philipp, Arzamendi, Dabit, Ander, Regueiro, Sabate, Manuel, Lala-Trindade, Anuradha, Adams, David, Swain, Julie, Orban, Mathias, Hausleiter, Jörg, Alfieri, Ottavio, Agricola, Eustachio, Montorfano, Matteo, Sinning, Jan-Malte, Tamm, Alexander, Hoffmann, Steffen, Kowalski, Marek, Garatti, Andrea, Pecoraro, Alessandra, Motta, Gessica, Tusa, Maurizio, Zuber, Michel, Windecker, Stephan, Samara, Michael, Mudy, Karol, Parikh, Sachin, Dee Wang, Dee, Piriou, Nicolas, Rommel, Karl-Philipp, Binner, Christian, Jimenez, Gustavo, Freixa, Xavier, Serra, Antonio, Lim, David, Lerakis, Stamatios, Buzzatti, Nicola, Baragagna, Marta, Tiburtius, Claudia, Grasso, Carmelo, De Marco, Federico, Maisano, Francesco, Taramasso, Maurizio, Bae, Richard, Frisoli, Tiberio, Guerin, Patrice, Hartung, Philipp, Mitter, Sumeet, Moss, Noah, Stocker, Thomas, Ancona, Francesco, Agricola, Eustachio, and Capogrosso, Cristina

Published
2023
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11. Calcification of surgical aortic bioprostheses and its impact on clinical outcome.

Author

Guimbretière, Guillaume, Sénage, Thomas, Boureau, Anne-Sophie, Roos, Jean-Charles, Bernard, Quentin, Carlier, Baptiste, Veziers, Joelle, Cueff, Caroline, Piriou, Nicolas, Coste, Guenola, Fellah, Imen, Lelarge, Coline, Capoulade, Romain, Jaafar, Philippe, Manigold, Thibaud, Letocart, Vincent, Warin-Fresse, Karine, Guérin, Patrice, Costa, Cristina, and Vadori, Marta

Subjects
CARDIOVASCULAR disease related mortality, IN vitro studies, AORTIC valve, RECEIVER operating characteristic curves, COMPUTED tomography, MAJOR adverse cardiovascular events, PROSTHETIC heart valves, CALCINOSIS, TREATMENT effectiveness, IN vivo studies, DESCRIPTIVE statistics, MULTIVARIATE analysis, HEART valve diseases, CONFIDENCE intervals, DISEASE risk factors
Abstract

Aims Aortic valve calcification (AVC) of surgical valve bioprostheses (BPs) has been poorly explored. We aimed to evaluate in vivo and ex vivo BP AVCs and its prognosis value. Methods and results Between 2011 and 2019, AVC was assessed using in vivo computed tomography (CT) in 361 patients who had undergone surgical valve replacement 6.4 ± 4.3 years earlier. Ex vivo CT scans were performed for 37 explanted BPs. The in vivo CT scans were interpretable for 342 patients (19 patients [5.2%] were excluded). These patients were 77.2 ± 9.1 years old, and 64.3% were male. Mean in vivo AVC was 307 ± 500 Agatston units (AU). The AVC was 562 ± 570 AU for the 183 (53.5%) patients with structural valve degeneration (SVD) and 13 ± 43 AU for those without SVD (P < 0.0001). In vivo and ex vivo AVCs were strongly correlated (r = 0.88, P < 0.0001). An in vivo AVC > 100 AU (n = 147, 43%) had a specificity of 96% for diagnosing Stage 2–3 SVD (area under the curve = 0.92). Patients with AVC > 100 AU had a worse outcome compared with those with AVC ≤ 100 AU (n = 195). In multivariable analysis, AVC was a predictor of overall mortality (hazard ratio [HR] and 95% confidence interval = 1.16 [1.04–1.29]; P = 0.006), cardiovascular mortality (HR = 1.22 [1.04–1.43]; P = 0.013), cardiovascular events (HR = 1.28 [1.16–1.41]; P < 0.0001), and re-intervention (HR = 1.15 [1.06–1.25]; P < 0.0001). After adjustment for Stage 2–3 SVD diagnosis, AVC remained a predictor of overall mortality (HR = 1.20 [1.04–1.39]; P = 0.015) and cardiovascular events (HR = 1.25 [1.09–1.43]; P = 0.001). Conclusion CT scan is a reliable tool to assess BP leaflet calcification. An AVC > 100 AU is tightly associated with SVD and it is a strong predictor of overall mortality and cardiovascular events. [ABSTRACT FROM AUTHOR]

Published
2024
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15. Current practices and access to cardiac bone scans for the detection of transthyretin cardiac amyloidosis based on the results of a large national electronic survey

Author

Hyafil, Fabien, primary, Oghina, Silvia, primary, Legallois, Damien, primary, Amara, Walid, primary, Andres, Emmanuel, primary, Bardin, Thomas, primary, Fournier, Pauline, primary, Guignard, Sandra, primary, Labeyrie, Céline, primary, Toulza, Olivier, primary, Tresorier, Romain, primary, Piriou, Nicolas, primary, SABOURET, Pierre, primary, Stanbury, Trevor, primary, Canali, Giorgia, primary, DUBOIS, Margaux, primary, Noirot-Cosson, Charlotte, primary, Rudant, Jeremie, primary, Bouquillon, Benoit, primary, Sauvage, Cedric, primary, Charron, Philippe, primary, and Damy, Thibaud, primary

Published
2024
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18. Evaluating the current physicians’ knowledge and patients’ pathways for diagnosing transthyretin cardiac amyloidosis (ATTR-CM) in France: An extensive survey of diverse medical specialists.

Author

Oghina, Silvia, primary, Legallois, Damien, primary, Hyafil, Fabien, primary, Amara, Walid, primary, Andres, Emmanuel, primary, Bardin, Thomas, primary, Fournier, Pauline, primary, Guignard, Sandra, primary, Labeyrie, Céline, primary, Piriou, Nicolas, primary, SABOURET, Pierre, primary, Toulza, Olivier, primary, Tresorier, Romain, primary, Stanbury, Trevor, primary, Canali, Giorgia, primary, DUBOIS, Margaux, primary, Noirot-Cosson, Charlotte, primary, Rudant, Jeremie, primary, Bouquillon, Benoit, primary, Sauvage, Cedric, primary, Charron, Philippe, primary, and Damy, Thibaud, primary

Published
2024
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24. Machine Learning–Based Phenogrouping in Mitral Valve Prolapse Identifies Profiles Associated With Myocardial Fibrosis and Cardiovascular Events

Author

Huttin, Olivier, primary, Girerd, Nicolas, additional, Jobbe-Duval, Antoine, additional, Constant Dit Beaufils, Anne-Laure, additional, Senage, Thomas, additional, Filippetti, Laura, additional, Cueff, Caroline, additional, Duarte, Kevin, additional, Fraix, Antoine, additional, Piriou, Nicolas, additional, Mandry, Damien, additional, Pace, Nathalie, additional, Le Scouarnec, Solena, additional, Capoulade, Romain, additional, Echivard, Matthieu, additional, Sellal, Jean Marc, additional, Marrec, Marie, additional, Beaumont, Marine, additional, Hossu, Gabriella, additional, Trochu, Jean-Noel, additional, Sadoul, Nicolas, additional, Marie, Pierre-Yves, additional, Guenancia, Charles, additional, Schott, Jean-Jacques, additional, Roussel, Jean-Christian, additional, Serfaty, Jean-Michel, additional, Selton-Suty, Christine, additional, and Le Tourneau, Thierry, additional

Published
2023
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25. Outcome and Morphofunctional Changes on Cardiac Magnetic Resonance in Patients With Acute Myocarditis Following mRNA COVID-19 Vaccination

Author

Ammirati, E, Lupi, L, Palazzini, M, Ciabatti, M, Rossi, V, Gentile, P, Uribarri, A, Vecchio, C, Nassiacos, D, Cereda, A, Conca, C, Tumminello, G, Piriou, N, Lelarge, C, Pedrotti, P, Stucchi, M, Peretto, G, Galasso, M, Huang, F, Ianni, U, Procopio, A, Saponara, G, Cimaglia, P, Tomasoni, D, Moroni, F, Turco, A, Sala, S, Di Tano, G, Bollano, E, Moro, C, Abbate, A, Della Bona, R, Porto, I, Carugo, S, Campodonico, J, Pontone, G, Grosu, A, Bolognese, L, Salamanca, J, Diez-Villanueva, P, Ozieranski, K, Tyminska, A, Sardo Infirri, L, Bromage, D, Cannatà, A, Hong, K, Adamo, M, Quattrocchi, G, Foà, A, Potena, L, Garascia, A, Giannattasio, C, Adler, E, Sinagra, G, Ruschitzka, F, Camici, P, Metra, M, Pieroni, M, Ammirati, Enrico, Lupi, Laura, Palazzini, Matteo, Ciabatti, Michele, Rossi, Valentina A, Gentile, Piero, Uribarri, Aitor, Vecchio, Chiara R, Nassiacos, Daniele, Cereda, Alberto, Conca, Cristina, Tumminello, Gabriele, Piriou, Nicolas, Lelarge, Coline, Pedrotti, Patrizia, Stucchi, Miriam, Peretto, Giovanni, Galasso, Michele, Huang, Florent, Ianni, Umberto, Procopio, Antonio, Saponara, Gianluigi, Cimaglia, Paolo, Tomasoni, Daniela, Moroni, Francesco, Turco, Annalisa, Sala, Simone, Di Tano, Giuseppe, Bollano, Entela, Moro, Claudio, Abbate, Antonio, Della Bona, Roberta, Porto, Italo, Carugo, Stefano, Campodonico, Jeness, Pontone, Gianluca, Grosu, Aurelia, Bolognese, Leonardo, Salamanca, Jorge, Diez-Villanueva, Pablo, Ozieranski, Krzysztof, Tyminska, Agata, Sardo Infirri, Loren, Bromage, Daniel, Cannatà, Antonio, Hong, Kimberly N, Adamo, Marianna, Quattrocchi, Giuseppina, Foà, Alberto, Potena, Luciano, Garascia, Andrea, Giannattasio, Cristina, Adler, Eric D, Sinagra, Gianfranco, Ruschitzka, Frank, Camici, Paolo G, Metra, Marco, Pieroni, Maurizio, Ammirati, E, Lupi, L, Palazzini, M, Ciabatti, M, Rossi, V, Gentile, P, Uribarri, A, Vecchio, C, Nassiacos, D, Cereda, A, Conca, C, Tumminello, G, Piriou, N, Lelarge, C, Pedrotti, P, Stucchi, M, Peretto, G, Galasso, M, Huang, F, Ianni, U, Procopio, A, Saponara, G, Cimaglia, P, Tomasoni, D, Moroni, F, Turco, A, Sala, S, Di Tano, G, Bollano, E, Moro, C, Abbate, A, Della Bona, R, Porto, I, Carugo, S, Campodonico, J, Pontone, G, Grosu, A, Bolognese, L, Salamanca, J, Diez-Villanueva, P, Ozieranski, K, Tyminska, A, Sardo Infirri, L, Bromage, D, Cannatà, A, Hong, K, Adamo, M, Quattrocchi, G, Foà, A, Potena, L, Garascia, A, Giannattasio, C, Adler, E, Sinagra, G, Ruschitzka, F, Camici, P, Metra, M, Pieroni, M, Ammirati, Enrico, Lupi, Laura, Palazzini, Matteo, Ciabatti, Michele, Rossi, Valentina A, Gentile, Piero, Uribarri, Aitor, Vecchio, Chiara R, Nassiacos, Daniele, Cereda, Alberto, Conca, Cristina, Tumminello, Gabriele, Piriou, Nicolas, Lelarge, Coline, Pedrotti, Patrizia, Stucchi, Miriam, Peretto, Giovanni, Galasso, Michele, Huang, Florent, Ianni, Umberto, Procopio, Antonio, Saponara, Gianluigi, Cimaglia, Paolo, Tomasoni, Daniela, Moroni, Francesco, Turco, Annalisa, Sala, Simone, Di Tano, Giuseppe, Bollano, Entela, Moro, Claudio, Abbate, Antonio, Della Bona, Roberta, Porto, Italo, Carugo, Stefano, Campodonico, Jeness, Pontone, Gianluca, Grosu, Aurelia, Bolognese, Leonardo, Salamanca, Jorge, Diez-Villanueva, Pablo, Ozieranski, Krzysztof, Tyminska, Agata, Sardo Infirri, Loren, Bromage, Daniel, Cannatà, Antonio, Hong, Kimberly N, Adamo, Marianna, Quattrocchi, Giuseppina, Foà, Alberto, Potena, Luciano, Garascia, Andrea, Giannattasio, Cristina, Adler, Eric D, Sinagra, Gianfranco, Ruschitzka, Frank, Camici, Paolo G, Metra, Marco, and Pieroni, Maurizio

Published
2023

26. Drug-induced aortic valve stenosis: An under recognized entity

Author

Ennezat, Pierre-Vladimir, Bruneval, Patrick, Czitrom, Daniel, Gueffet, Jean-Pierre, Piriou, Nicolas, Trochu, Jean Noël, Patra, Odile, Blanchard-Lemoine, Bénédicte, du Fretay, Xavier Halna, Nazeyrollas, Pierre, Assoun, Bernard, Jobic, Yannick, Brochet, Eric, Bogino, Emmanuel, Roudaut, Raymond, Augier, Caroline, Greffe, Lorraine, Petit-Eisenmann, Hélène, Dambrin, Camille, Chavanon, Olivier, Guillou, Louis, Grisoli, Dominique, Morera, Pierre, Banfi, Carlo, Remadi, Jean Paul, Fabre, Olivier, Vincentelli, André, Lantuejoul, Sylvie, Ikoli, Jean-Fortuné, Copin, Marie-Christine, Malergue, Marie-Christine, Maréchaux, Sylvestre, and Tribouilloy, Christophe

Published
2016
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27. Genetics and pathophysiology of mitral valve prolapse

Author

Delwarde, Constance, primary, Capoulade, Romain, additional, Mérot, Jean, additional, Le Scouarnec, Solena, additional, Bouatia-Naji, Nabila, additional, Yu, Mengyao, additional, Huttin, Olivier, additional, Selton-Suty, Christine, additional, Sellal, Jean-Marc, additional, Piriou, Nicolas, additional, Schott, Jean-Jacques, additional, Dina, Christian, additional, and Le Tourneau, Thierry, additional

Published
2023
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28. 138 OUTCOME AND MORPHO-FUNCTIONAL CHANGES ON CARDIAC MAGNETIC RESONANCE IN PATIENT WITH ACUTE MYOCARDITIS FOLLOWING MRNA COVID 19 VACCINATION

Author

Palazzini, Matteo, primary, Ammirati, Enrico, additional, Lupi, Laura, additional, Garascia, Andrea, additional, Gentile, Piero, additional, Pedrotti, Patrizia, additional, Giannattasio, Cristina, additional, Ciabatti, Michele, additional, Rossi, Valentina, additional, Ruschitzka, Frank, additional, Uribarri, Aitor, additional, Vecchio, Chiara, additional, Nassiacos, Daniele, additional, Cereda, Alberto, additional, Tumminiello, Gabriele, additional, Piriou, Nicolas, additional, Stucchi, Miriam, additional, Peretto, Giovanni, additional, Galasso, Michele, additional, Sala, Simone, additional, Camici, Paolo, additional, Huang, Florent, additional, Ianni, Umberto, additional, Procopio, Antonio, additional, Saponara, Gianluigi, additional, Cimaglia, Paolo, additional, Tomasoni, Daniela, additional, Moroni, Francesco, additional, Turco, Annalisa, additional, Di Tano, Giuseppe, additional, Bollano, Entela, additional, Moro, Claudio, additional, Abbate, Antonio, additional, Bona, Roberta Dalla, additional, Porto, Italo, additional, Carugo, Stefano, additional, Campodonico, Jeness, additional, Pontone, Gianluca, additional, Grosu, Aurelia, additional, Adamo, Marianna, additional, Salamanca, Jorge, additional, Ozieransky, Krzysztof, additional, Infirri, Loren Sardo, additional, Cannatà, Antonio, additional, Adler, Eric, additional, Sinagra, Gianfranco, additional, Metra, Marco, additional, and Pieroni, Maurizio, additional

Published
2022
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29. 132 PREVALENCE CHARACTERISTICS AND OUTCOMES OF COVID 19 ASSOCIATED ACUTE MYOCARDITIS

Author

Palazzini, Matteo, primary, Lupi, Laura, additional, Ammirati, Enrico, additional, Giannattasio, Cristina, additional, Soriano, Francesco, additional, Pedrotti, Patrizia, additional, Briguglia, Daniele, additional, Mapelli, Massimo, additional, Campodonico, Jeness, additional, Agostoni, Piergiuseppe, additional, Leonardi, Sergio, additional, Turco, Annalisa, additional, Guida, Stefania, additional, Peretto, Giovanni, additional, Sala, Simone, additional, Camici, Paolo G, additional, Marzo, Francesca, additional, Grosu, Aurelia, additional, Senni, Michele, additional, Turrini, Fabrizio, additional, Bramerio, Manuela, additional, Marini, Marco, additional, Matassini, Maria Vittoria, additional, Rizzo, Stefania, additional, Basso, Cristina, additional, De Gaspari, Monica, additional, Hendren, Nicholas S, additional, Schmidt, Matthieu, additional, Bochaton, Thomas, additional, Piriou, Nicolas, additional, Ubarri, Aitor, additional, Van De Heyning, Caroline, additional, Sole, Albert Ariza, additional, Cannatà, Antonio, additional, Salamanca, Jorge, additional, Lehtonen, Jukka, additional, Huang, Florent, additional, Adler, Eric D, additional, and Metra, Marco, additional

Published
2022
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30. Coronary artery disease and revascularization associated with immune checkpoint blocker myocarditis: Report from an international registry

Author

Nowatzke, Joseph, primary, Guedeney, Paul, additional, Palaskas, Nicholas, additional, Lehmann, Lorenz, additional, Ederhy, Stephane, additional, Zhu, Han, additional, Cautela, Jennifer, additional, Francis, Sanjeev, additional, Courand, Pierre-Yves, additional, Deswal, Anita, additional, Ewer, Steven M., additional, Aras, Mandar, additional, Arangalage, Dimitri, additional, Ghafourian, Kambiz, additional, Fenioux, Charlotte, additional, Finke, Daniel, additional, Peretto, Giovanni, additional, Zaha, Vlad, additional, Itzhaki Ben Zadok, Osnat, additional, Tajiri, Kazuko, additional, Akhter, Nausheen, additional, Levenson, Joshua, additional, Baldassarre, Lauren, additional, Power, John, additional, Huang, Shi, additional, Collet, Jean-Philippe, additional, Moslehi, Javid, additional, Salem, Joe-Elie, additional, Aghel, Nazanin, additional, Alexandre, Joachim, additional, Aonuma, Kazutaka, additional, Asnani, Aarti H., additional, Behling, Juliane, additional, Bilen, Mehmet, additional, Bottinor, Wendy, additional, Cariou, Eve, additional, Chahine, Johnny, additional, Chan, Weiting, additional, Chauhan, Aman, additional, Cohen, Max, additional, Crusz, Shanthini, additional, Fernando, Suran, additional, Florido, Roberta, additional, Frigeri, Mauro, additional, Fukushima, Satoshi, additional, Gaughan, Elizabeth, additional, Geisler, Benjamin P., additional, Gilstrap, Lauren, additional, Grohe, Christian, additional, Guha, Avirup, additional, Habib, Manhal, additional, Haegler-Laube, Eva, additional, Haydon, Andrew, additional, Hayek, Salim, additional, Hughes, Andrew, additional, Imai, Rysk, additional, Katsume, Yumi, additional, Kimura, Hideki, additional, Koo Lin, Lily, additional, Lenneman, Carrie, additional, Leong, Daryl, additional, Makker, Vicky, additional, Martinez-Calle, Nicolas, additional, Moey, Melissa, additional, Mohri, Masahiro, additional, Morimoto, Ryota, additional, Moritoki, Yoshinobu, additional, Narezkina, Anna, additional, Nicol, Martin, additional, Nooka, Ajay, additional, Orimoloye, Olusola, additional, Patel, Milan, additional, Perl, Michal, additional, Piriou, Nicolas, additional, Raikhelkar, Jayant K., additional, Raza, Yasmin, additional, Rao, Anjali, additional, Reddy, Sunil, additional, Seki, Nobuhiko, additional, Stangl, Karl, additional, Stewart, Andrew, additional, Stringer, Bryan, additional, Tamarappoo, Balaji K., additional, Tamura, Yuichi, additional, Thuny, Frank, additional, Tierney, Sean, additional, Tresorier, Romain, additional, Ullah, Waqas, additional, Von Hunolstein, Jean-Jacques, additional, Warner, Ellen, additional, and Weppler, Allison, additional

Published
2022
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32. Speckle tracking analysis allows sensitive detection of stress cardiomyopathy in severe aneurysmal subarachnoid hemorrhage patients

Author

Cinotti, Raphaël, Piriou, Nicolas, Launey, Yoann, Le Tourneau, Thierry, Lamer, Maxime, Delater, Adrien, and Trochu, Jean-Noël

Subjects
Subarachnoid hemorrhage -- Health aspects, Heart diseases -- Health aspects, Sufentanil -- Health aspects, Cardiomyopathy -- Health aspects, Health care industry
Abstract

Purpose Stress cardiomyopathy is a common life-threatening complication after aneurysmal subarachnoid hemorrhage (SAH). We hypothesized that left ventricular (LV) longitudinal strain alterations assessed with speckle tracking could identify early systolic function impairment. Methods This was an observational single-center prospective pilot controlled study conducted in a neuro-intensive care unit. Forty-six patients with severe SAH with a World Federation of Neurological Surgeons grade (WFNS) [greater than or equal to]III were included. Transthoracic echocardiography (TTE) was performed on day 1, day 3, and day 7 after the patient's admission. A cardiologist blinded to the patient's management analyzed the LV global longitudinal strain (GLS). The control group comprised normal subjects matched according to gender and age. Results On day 1 median (25th-75th percentile) GLS was clearly impaired in SAH patients compared to controls [-16.7 (-18.7/-13.7) % versus -20 (-22/-19) %, p < 0.0001], whereas LVEF was preserved [65 (59-70) %]. GLS was severely impaired in patients with a WFNS score of V versus III-IV [-15.6 (-16.9/-12.3) % versus -17.8 (-20.6/-15.8) %, p = 0.008]. Seventeen (37 %) patients had a severe GLS alteration (>-16 %). In these patients, GLS improved from day 1 [-12.4 (-14.8/-10.9) %] to last evaluation [-16.2 (-19/-14.6) %, p = 0.0007] in agreement with the natural evolution of stress cardiomyopathy. Conclusions On the basis of LV GLS assessment, we demonstrated for the first time that myocardial alteration compatible with a stress cardiomyopathy is detectable in up to 37 % of patients with severe SAH while LVEF is preserved. GLS could be used for sensitive detection of stress cardiomyopathy. This is critical because cardiac impairment remains a major cause of morbidity and mortality after SAH., Author(s): Raphaël Cinotti [sup.1], Nicolas Piriou [sup.2], Yoann Launey [sup.3], Thierry Le Tourneau [sup.4], Maxime Lamer [sup.2], Adrien Delater [sup.1], Jean-Noël Trochu [sup.2], Laurent Brisard [sup.5], Karim Lakhal [sup.5], Romain [...]

Published
2016
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34. Association of early electrical changes with cardiovascular outcomes in immune checkpoint inhibitor myocarditis

Author

Power, John R., primary, Alexandre, Joachim, additional, Choudhary, Arrush, additional, Ozbay, Benay, additional, Hayek, Salim S., additional, Asnani, Aarti, additional, Tamura, Yuichi, additional, Aras, Mandar, additional, Cautela, Jennifer, additional, Thuny, Franck, additional, Gilstrap, Lauren, additional, Arangalage, Dimitri, additional, Ewer, Steven, additional, Huang, Shi, additional, Deswal, Anita, additional, Palaskas, Nicolas L., additional, Finke, Daniel, additional, Lehmann, Lorenz H., additional, Ederhy, Stephane, additional, Moslehi, Javid, additional, Salem, Joe-Elie, additional, Fenioux, Charlotte, additional, Abbar, Baptiste, additional, Allenbach, Yves, additional, Crusz, Shanthini M., additional, Ghosh, Arjun K., additional, Moran, Tyler, additional, Mehegan, Tyler, additional, Piro, Lawrence, additional, Chang, Wei-Ting, additional, Chahine, Johnny, additional, Flint, Danette, additional, Stringer, Ben, additional, Gounant, Valérie, additional, Nicol, Martin, additional, Baroudjian, Barouyr, additional, Zimmer, Marie-Claire, additional, Mervoyer, Elvire, additional, Leong, Darryl, additional, Morimoto, Ryota, additional, Piriou, Nicolas, additional, Monge, Cecilia, additional, Copeland, Amy, additional, Ghafourian, Kambiz, additional, Guha, Avirup, additional, Brodsky, Sergey, additional, Ben Zadok, Osnat Itzhaki, additional, Habib, Manhal, additional, Dy, Grace, additional, Warner, Ellen, additional, Laufer-Perl, Michal, additional, Koo Lin, Lily, additional, Narezkina, Ana, additional, Baik, Alan, additional, Lenneman, Carrie, additional, Vachhani, Pankit, additional, Azam, Tariq U., additional, Perry, Daniel, additional, Blakely, Pennelope, additional, Tajiri, Kazuko, additional, Martini, Matthew, additional, Nowatzke, Joseph, additional, Orimoloye, Olusola Ayodeji, additional, Hughes, Andrew, additional, Baldassarre, Lauren A., additional, and Patel, Milan, additional

Published
2022
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35. Prevalence, Characteristics, and Outcomes of COVID-19–Associated Acute Myocarditis

Author

Ammirati, Enrico, primary, Lupi, Laura, additional, Palazzini, Matteo, additional, Hendren, Nicholas S., additional, Grodin, Justin L., additional, Cannistraci, Carlo V., additional, Schmidt, Matthieu, additional, Hekimian, Guillaume, additional, Peretto, Giovanni, additional, Bochaton, Thomas, additional, Hayek, Ahmad, additional, Piriou, Nicolas, additional, Leonardi, Sergio, additional, Guida, Stefania, additional, Turco, Annalisa, additional, Sala, Simone, additional, Uribarri, Aitor, additional, Van de Heyning, Caroline M., additional, Mapelli, Massimo, additional, Campodonico, Jeness, additional, Pedrotti, Patrizia, additional, Barrionuevo Sánchez, Maria Isabel, additional, Ariza Sole, Albert, additional, Marini, Marco, additional, Matassini, Maria Vittoria, additional, Vourc’h, Mickael, additional, Cannatà, Antonio, additional, Bromage, Daniel I., additional, Briguglia, Daniele, additional, Salamanca, Jorge, additional, Diez-Villanueva, Pablo, additional, Lehtonen, Jukka, additional, Huang, Florent, additional, Russel, Stéphanie, additional, Soriano, Francesco, additional, Turrini, Fabrizio, additional, Cipriani, Manlio, additional, Bramerio, Manuela, additional, Di Pasquale, Mattia, additional, Grosu, Aurelia, additional, Senni, Michele, additional, Farina, Davide, additional, Agostoni, Piergiuseppe, additional, Rizzo, Stefania, additional, De Gaspari, Monica, additional, Marzo, Francesca, additional, Duran, Jason M., additional, Adler, Eric D., additional, Giannattasio, Cristina, additional, Basso, Cristina, additional, McDonagh, Theresa, additional, Kerneis, Mathieu, additional, Combes, Alain, additional, Camici, Paolo G., additional, de Lemos, James A., additional, and Metra, Marco, additional

Published
2022
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36. Impact of procedural success on clinical outcome after MitraClip: Results from the MITRA-FR trial

Author

Messika-Zeitoun, David, Attias, David, Piriou, Nicolas, Iung, Bernard, Armoiry, Xavier, Trochu, Jean-Noël, Donal, Erwan, Habib, Gilbert, Cormier, Bertrand, Guerin, Patrice, Lefèvre, Thierry, Maucort-Boulch, Delphine, Boutitie, Florent, Vahanian, Alec, Riche, Benjamin, Obadia, Jean-François, University of Ottawa [Ottawa], Centre cardiologique du Nord (CCN), Centre hospitalier universitaire de Nantes (CHU Nantes), Laboratoire de Recherche Vasculaire Translationnelle (LVTS (UMR_S_1148 / U1148)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Université Sorbonne Paris Nord, Hôpital Edouard Herriot [CHU - HCL], Hospices Civils de Lyon (HCL), Matériaux, ingénierie et science [Villeurbanne] (MATEIS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Traitement du Signal et de l'Image (LTSI), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Pontchaillou [Rennes], Assistance Publique - Hôpitaux de Marseille (APHM), Microbes évolution phylogénie et infections (MEPHI), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Hôpital Privé Jacques Cartier [Massy], Regenerative Medicine and Skeleton (RMeS), École nationale vétérinaire, agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Nantes Université - UFR Odontologie (Nantes Univ – UFR Odonto), Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS), Hôpital Louis Pradel [CHU - HCL], This trial was funded by the French Ministry of Health and Research National Programme and Abbott Vascular. Abbott Vascular provided the devices and the support for the investigators’ meetings. Neither Abbott Vascular nor any other commercial entity had a role in trial design, participating centre selection, centre monitoring and oversight, data collection, patient enrolment, patient management, data storage, data analysis, data interpretation, the writing of the manuscript or the decision to submit the manuscript., and Service de Biostatistiques [Lyon]

Subjects
Heart Valve Prosthesis Implantation, Heart Failure, Mitral Valve Insufficiency, Stroke Volume, General Medicine, Outcomes, [SDV.MHEP.CHI]Life Sciences [q-bio]/Human health and pathology/Surgery, Ventricular Function, Left, Treatment Outcome, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Humans, Transcatheter mitral valve therapy, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Cardiology and Cardiovascular Medicine, Mitral regurgitation
Abstract

International audience; BACKGROUND: Differences in procedural success rates have been proposed to explain the divergent results between the MITRA-FR trial (Percutaneous Repair with the MitraClip Device for Severe Functional/Secondary Mitral Regurgitation) and the COAPT trial (Cardiovascular Outcomes Assessment of the MitraClip Percutaneous Therapy for Heart Failure Patients with Functional Mitral Regurgitation). AIM: To examine whether MITRA-FR patients who had successful clip implantation achieved a better outcome than the control group.METHODS: Based on the per protocol population of MITRA-FR, we compared the outcome in 71 patients in whom optimal clip implantation was achieved (group 1: mitral regurgitation grade ≤ 1 + at discharge) with that in 23 patients with non-optimal clip implantation (group 2: mitral regurgitation grade ≥ 2 + at discharge) and that in 137 patients in the control group (group 3). The primary endpoint was all-cause death or unplanned hospitalization for heart failure at 24 months.RESULTS: Event-free survival was not different across the groups (42±6% in group 1, 30±10% in group 2 and 31±4% in group 3; log-rank P=0.32). In multivariable analyses, after adjustment for age, sex, rhythm, aetiology, left ventricular ejection fraction and mitral regurgitation severity, group was not associated with variations in outcome: using Group 3 as reference, hazard ratio 0.86, 95% confidence interval 0.58-1.27 (P=0.43) in group 1; and hazard ratio 0.98 95% confidence interval 0.54-1.76 (P=0.94) in group 2.CONCLUSIONS: The clinical outcome of patients in whom optimal procedural result was achieved at discharge was not different compared with the control group. Our results do not support the hypothesis that the differences in rates of residual mitral regurgitation at discharge between MITRA-FR and COAPT explain the divergent results between the two trials.

Published
2021
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37. Electrocardiographic Manifestations of Immune Checkpoint Inhibitor Myocarditis

Author

Power, John R., primary, Alexandre, Joachim, additional, Choudhary, Arrush, additional, Ozbay, Benay, additional, Hayek, Salim, additional, Asnani, Aarti, additional, Tamura, Yuichi, additional, Aras, Mandar, additional, Cautela, Jennifer, additional, Thuny, Franck, additional, Gilstrap, Lauren, additional, Arangalage, Dimitri, additional, Ewer, Steven, additional, Huang, Shi, additional, Deswal, Anita, additional, Palaskas, Nicolas L., additional, Finke, Daniel, additional, Lehmann, Lorenz, additional, Ederhy, Stephane, additional, Moslehi, Javid, additional, Salem, Joe-Elie, additional, Abbar, Baptiste, additional, Allenbach, Yves, additional, Azam, Tariq U., additional, Baik, Alan, additional, Baldassarre, Lauren A., additional, Baroudjian, Barouyr, additional, Blakley, Pennelope, additional, Brodsky, Sergey, additional, Chahine, Johnny, additional, Chan, Wei-Ting, additional, Copeland, Amy, additional, Crusz, Shanthini M., additional, Dy, Grace, additional, Fenioux, Charlotte, additional, Ghafourian, Kambiz, additional, Ghosh, Arjun K., additional, Gounant, Valérie, additional, Guha, Avirup, additional, Habib, Manhal, additional, Zadok, Osnat Itzhaki Ben, additional, Lin, Lily Koo, additional, Laufer-Perl, Michal, additional, Lenneman, Carrie, additional, Leong, Darryl, additional, Martini, Matthew, additional, Meheghan, Tyler, additional, Mervoyer, Elvire, additional, Monge, Cecilia, additional, Morimoto, Ryota, additional, Narezkina, Anna, additional, Nicol, Martin, additional, Nowatzke, Joseph, additional, Orimoloye, Olusola Ayodeji, additional, Patel, Milan, additional, Perry, Daniel, additional, Piriou, Nicolas, additional, Piro, Lawrence, additional, Moran, Tyler, additional, Stringer, Ben, additional, Tajiri, Kazuko, additional, Vachhani, Pankit, additional, Warner, Ellen, additional, and Zimmer, Marie-Claire, additional

Published
2021
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39. Impact of Mitral Regurgitation Severity and Left Ventricular Remodeling on Outcome After Mitraclip Implantation: Results From the Mitra-FR Trial

Author

Messika-Zeitoun, David, Iung, Bernard, Armoiry, Xavier, Trochu, J.-N., Donal, Erwan, Habib, Gilbert, Brochet, Eric, Thibault, Hélène, Piriou, Nicolas, Cormier, Bertrand, Tribouilloy, Christophe, Guérin, Patrice, Lefèvre, Thierry, Maucort-Boulch, Delphine, Vahanian, Alec, Boutitie, Florent, Obadia, J.-F., University of Ottawa Heart Institute, University of Ottawa [Ottawa], Laboratoire de Recherche Vasculaire Translationnelle (LVTS (UMR_S_1148 / U1148)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Université Sorbonne Paris Nord, Matériaux, ingénierie et science [Villeurbanne] (MATEIS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS), Centre hospitalier universitaire de Nantes (CHU Nantes), Laboratoire Traitement du Signal et de l'Image (LTSI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), CHU Pontchaillou [Rennes], Assistance Publique - Hôpitaux de Marseille (APHM), Microbes évolution phylogénie et infections (MEPHI), Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU), AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Hospices Civils de Lyon, Departement de Neurologie (HCL), Hôpital Privé Jacques Cartier [Massy], Bien-être, Organisations, Numérique, Habitabilité, Education, Universalité, Relation, Savoirs (BONHEURS), CY Cergy Paris Université (CY), Regenerative Medicine and Skeleton research lab (RMeS), Ecole Nationale Vétérinaire, Agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS), Hôpital Louis Pradel [CHU - HCL], Hospices Civils de Lyon (HCL), Hospices Civils de Lyon, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Université Sorbonne Paris Nord, Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS), Hôpital Edouard Herriot [CHU - HCL], Institut du Thorax [Nantes], Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Hôpital de la Timone [CHU - APHM] (TIMONE), Institut Hospitalier Universitaire Méditerranée Infection (IHU Marseille), Groupement Hospitalier Lyon-Est (GHE), Mécanismes physiopathologiques et conséquences des calcifications vasculaires - UR UPJV 7517 (MP3CV), Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie, CHU Amiens-Picardie, Regenerative Medicine and Skeleton (RMeS), École nationale vétérinaire, agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Nantes Université - UFR Odontologie (Nantes Univ – UFR Odonto), Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), Université de Lyon, Service de Biostatistiques [Lyon], Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPC)-Université Sorbonne Paris Nord, Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM), École nationale vétérinaire, agroalimentaire et de l'alimentation Nantes-Atlantique (ONIRIS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), and Université de Nantes (UN)-Université de Nantes (UN)

Subjects
transcatheter mitral valve therapy, [SDV.IB]Life Sciences [q-bio]/Bioengineering, mitral regurgitation, outcomes
Abstract

International audience; Objectives - This study aimed to identify a subset of patients based on echocardiographic parameters who might have benefited from transcatheter correction using the Mitraclip system in the MITRA-FR (Percutaneous Repair with the MitraClip Device for Severe Functional/Secondary Mitral Regurgitation) trial. Background - It has been suggested that differences in the degree of mitral regurgitation (MR) and left ventricular (LV) remodeling may explain the conflicting results between the MITRA-FR and the COAPT (Cardiovascular Outcomes Assessment of the MitraClip Percutaneous Therapy for Heart Failure Patients with Functional Mitral Regurgitation) trials. Methods - In a post hoc analysis, we evaluated the interaction between the intervention and subsets of patients defined based on MR severity (effective regurgitant orifice [ERO], regurgitant volume [RVOL] and regurgitant fraction [RF]), LV remodeling (end-diastolic and end-systolic diameters and volumes) and combination of these parameters with respect to the composite of death from any cause or unplanned hospitalization for heart failure at 24 months. Results - We observed a neutral impact of the intervention in subsets with the highest MR degree (ERO ≥30 mm, RVOL ≥45 ml or RF ≥50%) as in patients with milder MR degree. The same was seen in subsets with the milder LV remodeling using either diastolic or systolic diameters or volumes. When parameters of MR severity and LV remodeling were combined, there was still no benefit of the intervention including in the subset of patients with an ERO/end-diastolic volume ratio ≥ 0.15 despite similar ERO and LV end-diastolic volume compared with COAPT patients. Conclusions - In the MITRA-FR trial, we could not identify a subset of patients defined based on the degree of the regurgitation, LV remodeling or on their combination, including those deemed as having disproportionate MR, that might have benefited from transcatheter correction using the Mitraclip system. (Multicentre Study of Percutaneous Mitral Valve Repair MitraClip Device in Patients With Severe Secondary Mitral Regurgitation [MITRA-FR]; NCT01920698).

Published
2021
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40. Replacement Myocardial Fibrosis in Patients With Mitral Valve Prolapse

Author

Constant Dit Beaufils, Anne-Laure, primary, Huttin, Olivier, additional, Jobbe-Duval, Antoine, additional, Senage, Thomas, additional, Filippetti, Laura, additional, Piriou, Nicolas, additional, Cueff, Caroline, additional, Venner, Clément, additional, Mandry, Damien, additional, Sellal, Jean-Marc, additional, Le Scouarnec, Solena, additional, Capoulade, Romain, additional, Marrec, Marie, additional, Thollet, Aurélie, additional, Beaumont, Marine, additional, Hossu, Gabriella, additional, Toquet, Claire, additional, Gourraud, Jean-Baptiste, additional, Trochu, Jean-Noël, additional, Warin-Fresse, Karine, additional, Marie, Pierre-Yves, additional, Schott, Jean-Jacques, additional, Roussel, Jean-Christian, additional, Serfaty, Jean-Michel, additional, Selton-Suty, Christine, additional, and Le Tourneau, Thierry, additional

Published
2021
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44. Amylose cardiaque dite sénile : diagnostic et nouvelles perspectives thérapeutiques: So-called senile cardiac amyloidosis: diagnosis and new therapeutic perspectives.

Author

Berrut, Gilles, Piriou, Nicolas, Boureau, Anne Sophie, Hanon, Olivier, and Trochu, Jean-Noël

Subjects
CARDIAC amyloidosis, AMYLOID plaque, HEART failure, AMYLOIDOSIS, TRANSTHYRETIN, TREATMENT failure
Abstract

Résumé: L'amylose cardiaque dite sénile, également dénommée « sauvage », était considérée comme une maladie rare. Actuellement, grâce à des moyens diagnostiques non invasifs et à partir d'études autopsiques, nous estimons la prévalence à environ 10 à 20 % des sujets de plus de 80 ans. De même, l'amylose était un diagnostic sans conséquence thérapeutique, mis à part le traitement de l'insuffisance cardiaque et des troubles de conduction. De nouveaux traitements permettent de stabiliser le tétramère de transthyrétine et de diminuer la production d'oligomères, sources des dépôts d'amylose, en cas de formes héréditaires et sauvage d'amylose à transthyrétine. Deux médicaments bloquant la production de transthyrétine (anti-sens et oligonucléotides) sont également en phase d'essais cliniques dans les amyloses cardiaques. Ainsi, le diagnostic et la prise en charge de l'amylose cardiaque deviennent des démarches diagnostiques de pratique clinique et doivent être connus des cardiologues, mais également des gériatres qui permettront une prise en charge précoce et donc plus efficace. So-called senile cardiac amyloidosis was considered rare. Nowadays, thanks to non-invasive diagnostic means and autopsy studies, we estimate the prevalence to be about 20% of subjects over 75 years of age. Similarly, amyloidosis was a diagnosis with no therapeutic consequences, apart from the treatment of heart failure and conduction disorders. New treatments make it possible to stabilise the transthyretin tetramer and to reduce the production of oligomers that are the source of amyloid deposits, by acting in a non-genetic way and therefore adapted to the "wild" transthyretin forms of so-called senile cardiac amyloidosis. Thus, the diagnosis and management of cardiac amyloidosis are becoming diagnostic procedures in clinical practice and must be known by cardiologists, but also by geriatricians, who will allow early and therefore more effective management. [ABSTRACT FROM AUTHOR]

Published
2022
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45. Overexpression of endothelial β 3 ‐adrenergic receptor induces diastolic dysfunction in rats

Author

Dhot, Justine, primary, Ferron, Marine, additional, Prat, Valentine, additional, Persello, Antoine, additional, Roul, David, additional, Stévant, David, additional, Guijarro, Damien, additional, Piriou, Nicolas, additional, Aillerie, Virginie, additional, Erraud, Angélique, additional, Toumaniantz, Gilles, additional, Erfanian, Morteza, additional, Tesse, Angela, additional, Grabherr, Amandine, additional, Tesson, Laurent, additional, Menoret, Séverine, additional, Anegon, Ignacio, additional, Trochu, Jean‐Noël, additional, Steenman, Marja, additional, De Waard, Michel, additional, Rozec, Bertrand, additional, Lauzier, Benjamin, additional, and Gauthier, Chantal, additional

Published
2020
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46. Familial screening in case of acute myocarditis reveals inherited arrhythmogenic left ventricular cardiomyopathies

Author

Piriou, Nicolas, primary, Marteau, Lara, additional, Kyndt, Florence, additional, Serfaty, Jean Michel, additional, Toquet, Claire, additional, Le Gloan, Laurianne, additional, Warin‐Fresse, Karine, additional, Guijarro, Damien, additional, Le Tourneau, Thierry, additional, Conan, Emilie, additional, Thollet, Aurélie, additional, Probst, Vincent, additional, and Trochu, Jean‐Noël, additional

Published
2020
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48. The impact of digitization on the trajectory of a complementary local currency: The Eusko in the Northern Basque Country

Author

CHRISTY, Xebax, EDE-SANJURJO, DANTE, Fois-Duclerc, Mathilde, Lung, Yannick, MILANESI, Julien, Pinos, Fabienne, Piriou, Nicolas, POVEDA, Txomin, Centre Émile Durkheim (CED), Sciences Po Bordeaux - Institut d'études politiques de Bordeaux (IEP Bordeaux)-Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS), Groupe de Recherche en Economie Théorique et Appliquée (GREThA), Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'analyse et de recherche en économie et finance internationales (Larefi), Université de Bordeaux (UB), RAMICS, Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS)-Sciences Po Bordeaux - Institut d'études politiques de Bordeaux (IEP Bordeaux), and Centre National de la Recherche Scientifique (CNRS)-Université de Bordeaux (UB)

Subjects
Northern Basque Country, [QFIN]Quantitative Finance [q-fin], digitization, local currency, ComputingMilieux_MISCELLANEOUS, [SHS.SCIPO]Humanities and Social Sciences/Political science, Eusko
Abstract

International audience

Published
2019

49. Percutaneous repair or medical treatment for secondary mitral regurgitation: outcomes at 2 years Methods and results

Author

Iung, Bernard, Armoiry, Xavier, Vahanian, Alec, Boutitie, Florent, Mewton, Nathan, Trochu, Jean-Noël, Lefèvre, Thierry, Messika-Zeitoun, David, Guerin, Patrice, Cormier, Bertrand, Brochet, Eric, Thibault, Hélène, Himbert, Dominique, Thivolet, Sophie, Leurent, Guillaume, Bonnet, Guillaume, Donal, Erwan, Piriou, Nicolas, Piot, Christophe, Habib, Gilbert, Rouleau, Frederic, Nejjari, Mohammed, Ohlmann, Patrick, Saint, Christophe, 17, Etienne, Leroux, Lionel, Gilard, Martine, Samson, Géraldine, Rioufol, Gilles, Maucort-Boulch, Delphine, Obadia, Jean, CIC - CHU Bichat, Institut National de la Santé et de la Recherche Médicale (INSERM), Pharmacy Department/ Cellule Innovation, Hospices Civils de Lyon (HCL), Service de cardiologie, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7), Biostatistiques santé, Département biostatistiques et modélisation pour la santé et l'environnement [LBBE], Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS), Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM), unité de recherche de l'institut du thorax UMR1087 UMR6291 (ITX), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), Hémostase, bio-ingénierie et remodelage cardiovasculaires (LBPC), Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Institut Galilée-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre spécialisé Obésité, CHU Bordeaux [Bordeaux], Service de Cardiologie, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), CHU Pontchaillou [Rennes], Université de Bordeaux (UB), Laboratoire Traitement du Signal et de l'Image (LTSI), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de Génomique Fonctionnelle (IGF), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Université de la Méditerranée - Aix-Marseille 2-Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE), Physiopathologie Cardiovasculaire et Mitochondriale (MITOVASC), Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Adaptation cardiovasculaire à l'ischemie, Université Bordeaux Segalen - Bordeaux 2-Institut National de la Santé et de la Recherche Médicale (INSERM), Optimisation des régulations physiologiques (ORPHY (EA 4324)), Université de Brest (UBO)-Centre Hospitalier Régional Universitaire de Brest (CHRU Brest)-Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO)-Université de Brest (UBO), Mateis, Laboratoire, Unité de recherche de l'institut du thorax (ITX-lab), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), MitoVasc - Physiopathologie Cardiovasculaire et Mitochondriale (MITOVASC), Service de Biostatistiques [Lyon], Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National de la Recherche Agronomique (INRA), Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université Paris Diderot - Paris 7 (UPD7)-Université Paris 13 (UP13)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Galilée, Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-AP-HP - Hôpital Bichat - Claude Bernard [Paris]-Université Paris Diderot - Paris 7 (UPD7), Laboratoire Biostatistique-Santé (LBS), Université de Lyon-Université de Lyon-Hospices Civils de Lyon (HCL)-Centre National de la Recherche Scientifique (CNRS), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hospices Civils de Lyon (HCL), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Institut Brestois Santé Agro Matière (IBSAM), and Université de Brest (UBO)-Université de Brest (UBO)-Université de Brest (UBO)-Centre Hospitalier Régional Universitaire de Brest (CHRU Brest)

Subjects
Percutaneous mitral valve repair, Secondary mitral regurgitation, Heart failure, [SPI.MAT] Engineering Sciences [physics]/Materials, [SPI.MAT]Engineering Sciences [physics]/Materials
Abstract

International audience; Aims The MITRA-FR trial showed that among symptomatic patients with severe secondary mitral regurgitation, percu-taneous repair did not reduce the risk of death or hospitalization for heart failure at 12 months compared with guideline-directed medical treatment alone. At 37 centres, we randomly assigned 304 symptomatic heart failure patients with severe secondary mitral regurgitation (effective regurgitant orifice area >20 mm 2 or regurgitant volume >30 mL), and left ventricular ejection fraction between 15% and 40% to undergo percutaneous valve repair plus medical treatment (intervention group, n = 152) or medical treatment alone (control group, n = 152). The primary efficacy outcome was the composite of all-cause death and unplanned hospitalization for heart failure at 12 months. At 24 months, all-cause death and unplanned hospitalization for heart failure occurred in 63.8% of patients (97/152) in the intervention group and 67.1% (102/152) in the control group [hazard ratio (HR) 1.01, 95% confidence interval (CI) 0.77-1.34]. All-cause *Corresponding author. Hôpital Cardiovasculaire Louis Pradel, Chirurgie Cardio-Vasculaire et Transplantation Cardiaque

Published
2019
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50. Impact of Systematic Whole-body 18F-Fluorodeoxyglucose PET/CT on the Management of Patients Suspected of Infective Endocarditis: The Prospective Multicenter TEPvENDO Study.

Author

Duval, Xavier, Moing, Vincent Le, Tubiana, Sarah, Esposito-Farèse, Marina, Ilic-Habensus, Emila, Leclercq, Florence, Bourdon, Aurélie, Goehringer, François, Selton-Suty, Christine, Chevalier, Elodie, Boutoille, David, Piriou, Nicolas, Tourneau, Thierry Le, Chirouze, Catherine, Seronde, Marie-France, Morel, Olivier, Piroth, Lionel, Eicher, Jean-Christophe, Humbert, Olivier, and Revest, Matthieu

Subjects
DIAGNOSIS of endocarditis, TREATMENT of endocarditis, RESEARCH, ECHOCARDIOGRAPHY, CLINICAL trials, CONFIDENCE intervals, MEDICAL cooperation, TREATMENT effectiveness, RADIOPHARMACEUTICALS, PROSTHETIC heart valves, DESCRIPTIVE statistics, DEOXY sugars, COMPUTED tomography, LONGITUDINAL method
Abstract

Background Diagnostic and patients' management modifications induced by whole-body 18F-FDG-PET/CT had not been evaluated so far in prosthetic valve (PV) or native valve (NV) infective endocarditis (IE)-suspected patients. Methods In sum, 140 consecutive patients in 8 tertiary care hospitals underwent 18F-FDG-PET/CT. ESC-2015-modified Duke criteria and patients' management plan were established jointly by 2 experts before 18F-FDG-PET/CT. The same experts reestablished Duke classification and patients' management plan immediately after qualitative interpretation of 18F-FDG-PET/CT. A 6-month final Duke classification was established. Results Among the 70 PV and 70 NV patients, 34 and 46 were classified as definite IE before 18F-FDG-PET/CT. Abnormal perivalvular 18F-FDG uptake was recorded in 67.2% PV and 24.3% NV patients respectively (P <.001) and extracardiac uptake in 44.3% PV and 51.4% NV patients. IE classification was modified in 24.3% and 5.7% patients (P =.005) (net reclassification index 20% and 4.3%). Patients' managements were modified in 21.4% PV and 31.4% NV patients (P =.25). It was mainly due to perivalvular uptake in PV patients and to extra-cardiac uptake in NV patients and consisted in surgery plan modifications in 7 patients, antibiotic plan modifications in 22 patients and both in 5 patients. Altogether, 18F-FDG-PET/CT modified classification and/or care in 40% of the patients (95% confidence interval: 32–48), which was most likely to occur in those with a noncontributing echocardiography (P <.001) or IE classified as possible at baseline (P =.04), while there was no difference between NV and PV. Conclusions Systematic 18F-FDG-PET/CT did significantly and appropriately impact diagnostic classification and/or IE management in PV and NV-IE suspected patients. Clinical Trials Registration NCT02287792. [ABSTRACT FROM AUTHOR]

Published
2021
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