1. [Neurosurgical treatment of tumors of the pineal region - literature review and overview of cases at OMIII].
- Author
-
Mezei T, Báskay J, Pollner P, Kovács V, Markia B, Nagy G, Bajcsay A, and Sipos L
- Subjects
- Adult, Humans, Combined Modality Therapy, Retrospective Studies, Brain Neoplasms radiotherapy, Brain Neoplasms surgery, Brain Neoplasms pathology, Pineal Gland surgery, Pineal Gland pathology, Pinealoma radiotherapy, Pinealoma surgery, Pinealoma pathology
- Abstract
Pineal region tumors account for less than 1% of adult supratentorial tumors. Their treatment requires a multimodality approach. Previously, the treatment of choice was direct surgery, which is associated with high surgical risk. Advances in minimally invasive techniques and onco-radiotherapy offer a safe and multimodal personalized therapy. The aim of our study was to describe the practice of our Institute based on combined endoscopic and radiotherapy techniques. We performed a retrospective clinical study. We processed data from 23 adult patients who underwent endoscopic third ventricle fenestration and pineal tumor biopsy between 2014 and 2023. Descriptive statistics, t-test, Fisher's exact test and Kaplan-Meier analysis were performed. Clinical improvement with endoscopic intervention was achieved in 78.3% of cases. Significant increase in preoperative performance status was observed in the postoperative period (p=2.755e-5), and radiotherapy resulted in regression or stable disease. Our results suggest a safe treatment with good clinical outcome and an excellent alternative to direct surgery.
- Published
- 2024