A Case Report of Adult Pineoblastoma Occurring in a Pregnant Woman.

Authors :: Cuccia F
Mortellaro G
Cespuglio D
Valenti V
DE Gregorio G
Quartuccio E
Blasi L
Francaviglia N
Gallo C
Lo Casto A
Ferrera G
Source :: Anticancer research [Anticancer Res] 2019 May; Vol. 39 (5), pp. 2627-2631.
Publication Year :: 2019
Abstract: Background/aim: Pineoblastoma of the adult age is an uncommon tumor with only 200 cases reported. A standardized approach for an optimal adjuvant strategy is currently lacking. The case presented herein also deals with the issue of central nervous system tumors in pregnancy.<br />Case Report: A 21-year-old pregnant woman presented with massive hydrocephalus due to a mass in the pineal region detected with MRI. After positioning an urgent ventricular derivation, a cesarean section was performed. During a third ventriculocisternostomy, a biopsy revealed a pineoblastoma. After a maximal safe resection, postoperative craniospinal irradiation for a total dose of 36 Gy plus a sequential boost to the tumor bed to 54 Gy, and adjuvant chemotherapy with CDDP plus CCNU plus vincristine were performed. After one year, the patient is alive with no evidence of disease.<br />Conclusion: The use of adjuvant radio-chemotherapy provided excellent outcomes in our case. The advanced gestational age facilitated the choice of the therapeutic strategy.<br /> (Copyright© 2019, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)