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4. Clinical Outcomes and Patient-Matched Molecular Composition of Relapsed Medulloblastoma.

Author

Kumar, Rahul, Smith, Kyle, Deng, Maximilian, Terhune, Colt, Robinson, Giles, Orr, Brent, Liu, Anthony, Lin, Tong, Billups, Catherine, Chintagumpala, Murali, Bowers, Daniel, Hassall, Timothy, Hansford, Jordan, Khuong-Quang, Dong, Crawford, John, Bendel, Anne, Gururangan, Sridharan, Schroeder, Kristin, Bouffet, Eric, Bartels, Ute, Fisher, Michael, Cohn, Richard, Partap, Sonia, Kellie, Stewart, McCowage, Geoffrey, Paulino, Arnold, Rutkowski, Stefan, Fleischhack, Gudrun, Dhall, Girish, Klesse, Laura, Leary, Sarah, Nazarian, Javad, Kool, Marcel, Wesseling, Pieter, Ryzhova, Marina, Zheludkova, Olga, Golanov, Andrey, McLendon, Roger, Packer, Roger, Dunham, Christopher, Hukin, Juliette, Fouladi, Maryam, Faria, Claudia, Pimentel, Jose, Walter, Andrew, Jabado, Nada, Cho, Yoon-Jae, Perreault, Sebastien, Croul, Sidney, Zapotocky, Michal, Hawkins, Cynthia, Tabori, Uri, Taylor, Michael, Pfister, Stefan, Klimo, Paul, Boop, Frederick, Ellison, David, Merchant, Thomas, Onar-Thomas, Arzu, Korshunov, Andrey, Jones, David, Gajjar, Amar, Ramaswamy, Vijay, and Northcott, Paul

Subjects
Biomarkers, Tumor, Cerebellar Neoplasms, Child, Child, Preschool, Clinical Trials as Topic, DNA Methylation, Disease Progression, Epigenome, Epigenomics, Female, High-Throughput Nucleotide Sequencing, Humans, Infant, Male, Medulloblastoma, Neoplasm Recurrence, Local, Retreatment, Time Factors, Treatment Outcome
Abstract

PURPOSE: We sought to investigate clinical outcomes of relapsed medulloblastoma and to compare molecular features between patient-matched diagnostic and relapsed tumors. METHODS: Children and infants enrolled on either SJMB03 (NCT00085202) or SJYC07 (NCT00602667) trials who experienced medulloblastoma relapse were analyzed for clinical outcomes, including anatomic and temporal patterns of relapse and postrelapse survival. A largely independent, paired molecular cohort was analyzed by DNA methylation array and next-generation sequencing. RESULTS: A total of 72 of 329 (22%) SJMB03 and 52 of 79 (66%) SJYC07 patients experienced relapse with significant representation of Group 3 and wingless tumors. Although most patients exhibited some distal disease (79%), 38% of patients with sonic hedgehog tumors experienced isolated local relapse. Time to relapse and postrelapse survival varied by molecular subgroup with longer latencies for patients with Group 4 tumors. Postrelapse radiation therapy among previously nonirradiated SJYC07 patients was associated with long-term survival. Reirradiation was only temporizing for SJMB03 patients. Among 127 patients with patient-matched tumor pairs, 9 (7%) experienced subsequent nonmedulloblastoma CNS malignancies. Subgroup (96%) and subtype (80%) stabilities were largely maintained among the remainder. Rare subgroup divergence was observed from Group 4 to Group 3 tumors, which is coincident with genetic alterations involving MYC, MYCN, and FBXW7. Subgroup-specific patterns of alteration were identified for driver genes and chromosome arms. CONCLUSION: Clinical behavior of relapsed medulloblastoma must be contextualized in terms of up-front therapies and molecular classifications. Group 4 tumors exhibit slower biological progression. Utility of radiation at relapse is dependent on patient age and prior treatments. Degree and patterns of molecular conservation at relapse vary by subgroup. Relapse tissue enables verification of molecular targets and identification of occult secondary malignancies.

Published
2021

16. Seizure outcome and use of antiepileptic drugs after epilepsy surgery according to histopathological diagnosis: a retrospective multicentre cohort study

Author

Aichholzer, Martin, Amorim, Isabel, Aparicio, Javier, Aronica, Eleonora, Arzimanoglou, Alexis, Barba, Carmen, Beck, Jürgen, Becker, Albert, Beckervordersandforth, Jan C, Bien, Christian G, Blümcke, Ingmar, Bodi, Istvan, Braun, Kees PJ, Catenoix, Helene, Chassoux, Francine, Chipaux, Mathilde, Cloppenborg, Thomas, Coras, Roland, Cross, J Helen, De Palma, Luca, De Tisi, Jane, Deleo, Francesco, Devaux, Bertrand, Di Gennaro, Giancarlo, Dorfmüller, Georg, Duncan, John S, Elger, Christian, Ernst, Katharina, Esposito, Vincenzo, Feucht, Martha, Gadze, Zeljka Petelin, Garbelli, Rita, Geleijns, Karin, Gil-Nagel, Antonio, Grote, Alexander, Grunwald, Thomas, Guerrini, Renzo, Hamer, Hajo, Honavar, Mrinalini, Jacques, Thomas S, Jakovcevic, Antonia, Jutila, Leena, Kalina, Adam, Kälviäinen, Reetta, Klein, Karl Martin, Koenig, Kristina, Krsek, Pavel, Kudernatsch, Manfred, Kudr, Martin, Lamberink, Herm J, Malmgren, Kristina, Marusic, Petr, Melikyan, Armen, Menzler, Katja, Noachtar, Soheyl, Otte, Willem M, Özkara, Çiğdem, Pieper, Tom, Pimentel, Jose, Raicevic, Savo, Rheims, Sylvain, Ribeiro, Joana, Rosenow, Felix, Rössler, Karl, Rydenhag, Bertil, Sales, Francisco, San Antonio-Arce, Victoria, Schaller, Karl Lothar, Schijns, Olaf, Scholl, Theresa, Schramm, Johannes, Schulze-Bonhage, Andreas, Sciot, Raf, Seeck, Margitta, Shishkina, Lyudmila, Sokic, Dragoslav, Specchio, Nicola, Theys, Tom, Thom, Maria, Delgado, Rafael Toledano, Toulouse, Joseph, Uzan, Mustafa, van Loon, Johannes, Van Paesschen, Wim, von Oertzen, Tim J, Jansen, Floor, Leijten, Frans, van Rijen, Peter, Spliet, Wim GM, Mühlebner, Angelika, Kasper, Burkhard S, Fauser, Susanne, Polster, Tilman, Kalbhenn, Thilo, Delev, Daniel, McEvoy, Andrew, Miserocchi, Anna, Landré, Elisabeth, Turak, Bares, Varlet, Pascale, Ferrand-Sorbets, Sarah, Fohlen, Martine, Bulteau, Christine, Edelvik, Anna, Shah, Mukesch J, Scheiwe, Christian, Delicado, Eva Gutierrez, Tisdall, Martin, Eltze, Christin, Akkol, Serdar, Deniz, Kaancan, Oz, Buge, Holthausen, Hans, Hartlieb, Till, Staudt, Martin, Casciato, Sara, Quarato, Pier P, Giangaspero, Felice, Streichenberger, Nathalie, Guenot, Marc, Isnard, Jean, Valentijn, Antonio, Chang, Amanda, Mullatti, Nandini, Zamecnik, Josef, Zarubova, Jana, Tomasek, Martin, Immonen, Arto, Saarela, Anni, Rauramaa, Tuomas, Lobrinus, Johannes A, Egervari, Kristof, Momjian, Shahan, Harti, Elisabeth, Lohr, Hannah, Kroell, Judith, Vermeulen, Lynn, Cleeren, Evy, Vlasov, Pavel, Kozlova, Antonia, Vorobyev, Alexey, Goeppel, Gudrun, Samueli, Sharon, Czech, Thomas, Hainfellner, Johannes, Puttinger, Gertraud, Schwarz, Gabriele, Stefanits, Harald, Weis, Serge, Spreafico, Roberto, Villani, Flavio, Rossini, Laura, Hermsen, Anke, Knake, Susanne, Nimsky, Christopher, Carl, Barbara, Belohlavkova, Anezka, Benova, Barbora, Bisschop, Jeroen, Colon, Albert, van Kranen-Mastenbroek, Vivianne, Rouhl, Rob PW, Hoogland, Govert, Rumiá, Jordi, Ramírez-Camacho, Alia, Candela-Cantó, Santiago, Ostrowsky-Coste, Karine, Panagiotakaki, Eleni, Montavont, Alexandra, Kosal, Pascale Keo, Gokce-Samar, Zeynep, Milleret, Clara, Buccoliero, Anna M, Giordano, Flavio, Sulentic, Vlatko, Mrak, Goran, Desnica, Andrej, CarfíPavia, Giusy, De Benedictis, Alessandro, Marras, Carlo E, Bascarevic, Vladimir, Vojvodic, Nikola, Ristic, Aleksandar, Rebelo, Olinda, Aledo-Serrano, Angel, Garcia-Morales, Irene, Anciones, Carla, and Braun, Kees P J

Published
2020
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17. Hoyosella

Author

Valme, Jurado, primary, Luis, Gonzalez‐Pimentel Jose, additional, Delphine, Mouniée, additional, and Veronica, Rodriguez‐Nava, additional

Published
2024
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18. Integrated (epi)-Genomic Analyses Identify Subgroup-Specific Therapeutic Targets in CNS Rhabdoid Tumors

Author

Torchia, Jonathon, Golbourn, Brian, Feng, Shengrui, Ho, Ching, Sin-Chan, Patrick, Vasiljevic, Alexandre, Norman, Joseph D, Guilhamon, Paul, Garzia, Livia, Agamez, Natalia R, Lu, Mei, Chan, Tiffany S, Picard, Daniel, de Antonellis, Pasqualino, Khuong-Quang, Dong-Anh, Planello, Aline C, Zeller, Constanze, Barsyte-Lovejoy, Dalia, Lafay-Cousin, Lucie, Letourneau, Louis, Bourgey, Mathieu, Yu, Man, Gendoo, Deena MA, Dzamba, Misko, Barszczyk, Mark, Medina, Tiago, Riemenschneider, Alexandra N, Morrissy, A Sorana, Ra, Young-Shin, Ramaswamy, Vijay, Remke, Marc, Dunham, Christopher P, Yip, Stephen, Ng, Ho-keung, Lu, Jian-Qiang, Mehta, Vivek, Albrecht, Steffen, Pimentel, Jose, Chan, Jennifer A, Somers, Gino R, Faria, Claudia C, Roque, Lucia, Fouladi, Maryam, Hoffman, Lindsey M, Moore, Andrew S, Wang, Yin, Choi, Seung Ah, Hansford, Jordan R, Catchpoole, Daniel, Birks, Diane K, Foreman, Nicholas K, Strother, Doug, Klekner, Almos, Bognár, Laszló, Garami, Miklós, Hauser, Péter, Hortobágyi, Tibor, Wilson, Beverly, Hukin, Juliette, Carret, Anne-Sophie, Van Meter, Timothy E, Hwang, Eugene I, Gajjar, Amar, Chiou, Shih-Hwa, Nakamura, Hideo, Toledano, Helen, Fried, Iris, Fults, Daniel, Wataya, Takafumi, Fryer, Chris, Eisenstat, David D, Scheinemann, Katrin, Fleming, Adam J, Johnston, Donna L, Michaud, Jean, Zelcer, Shayna, Hammond, Robert, Afzal, Samina, Ramsay, David A, Sirachainan, Nongnuch, Hongeng, Suradej, Larbcharoensub, Noppadol, Grundy, Richard G, Lulla, Rishi R, Fangusaro, Jason R, Druker, Harriet, Bartels, Ute, Grant, Ronald, Malkin, David, McGlade, C Jane, Nicolaides, Theodore, Tihan, Tarik, Phillips, Joanna, Majewski, Jacek, Montpetit, Alexandre, Bourque, Guillaume, Bader, Gary D, Reddy, Alyssa T, Gillespie, G Yancey, and Warmuth-Metz, Monika

Subjects
Genetics, Human Genome, Rare Diseases, Orphan Drug, Cancer, 2.1 Biological and endogenous factors, Development of treatments and therapeutic interventions, Aetiology, 5.1 Pharmaceuticals, Cell Line, Tumor, Cell Proliferation, Cell Survival, Central Nervous System Neoplasms, Chromatin, DNA Methylation, Dasatinib, Epigenesis, Genetic, Epigenomics, Humans, Mutation, Protein Kinase Inhibitors, Pyrimidines, Receptor, Platelet-Derived Growth Factor beta, Rhabdoid Tumor, SMARCB1 Protein, Teratoma, ATRT, enhancer, epigenomics, genomics, rhabdoid tumors, subgroup-specific therapeutics, Neurosciences, Oncology and Carcinogenesis, Oncology & Carcinogenesis
Abstract

We recently reported that atypical teratoid rhabdoid tumors (ATRTs) comprise at least two transcriptional subtypes with different clinical outcomes; however, the mechanisms underlying therapeutic heterogeneity remained unclear. In this study, we analyzed 191 primary ATRTs and 10 ATRT cell lines to define the genomic and epigenomic landscape of ATRTs and identify subgroup-specific therapeutic targets. We found ATRTs segregated into three epigenetic subgroups with distinct genomic profiles, SMARCB1 genotypes, and chromatin landscape that correlated with differential cellular responses to a panel of signaling and epigenetic inhibitors. Significantly, we discovered that differential methylation of a PDGFRB-associated enhancer confers specific sensitivity of group 2 ATRT cells to dasatinib and nilotinib, and suggest that these are promising therapies for this highly lethal ATRT subtype.

Published
2016

27. Intertumoral Heterogeneity within Medulloblastoma Subgroups

Author

Cavalli, Florence M.G., Remke, Marc, Rampasek, Ladislav, Peacock, John, Shih, David J.H., Luu, Betty, Garzia, Livia, Torchia, Jonathon, Nor, Carolina, Morrissy, A. Sorana, Agnihotri, Sameer, Thompson, Yuan Yao, Kuzan-Fischer, Claudia M., Farooq, Hamza, Isaev, Keren, Daniels, Craig, Cho, Byung-Kyu, Kim, Seung-Ki, Wang, Kyu-Chang, Lee, Ji Yeoun, Grajkowska, Wieslawa A., Perek-Polnik, Marta, Vasiljevic, Alexandre, Faure-Conter, Cecile, Jouvet, Anne, Giannini, Caterina, Nageswara Rao, Amulya A., Li, Kay Ka Wai, Ng, Ho-Keung, Eberhart, Charles G., Pollack, Ian F., Hamilton, Ronald L., Gillespie, G. Yancey, Olson, James M., Leary, Sarah, Weiss, William A., Lach, Boleslaw, Chambless, Lola B., Thompson, Reid C., Cooper, Michael K., Vibhakar, Rajeev, Hauser, Peter, van Veelen, Marie-Lise C., Kros, Johan M., French, Pim J., Ra, Young Shin, Kumabe, Toshihiro, López-Aguilar, Enrique, Zitterbart, Karel, Sterba, Jaroslav, Finocchiaro, Gaetano, Massimino, Maura, Van Meir, Erwin G., Osuka, Satoru, Shofuda, Tomoko, Klekner, Almos, Zollo, Massimo, Leonard, Jeffrey R., Rubin, Joshua B., Jabado, Nada, Albrecht, Steffen, Mora, Jaume, Van Meter, Timothy E., Jung, Shin, Moore, Andrew S., Hallahan, Andrew R., Chan, Jennifer A., Tirapelli, Daniela P.C., Carlotti, Carlos G., Fouladi, Maryam, Pimentel, José, Faria, Claudia C., Saad, Ali G., Massimi, Luca, Liau, Linda M., Wheeler, Helen, Nakamura, Hideo, Elbabaa, Samer K., Perezpeña-Diazconti, Mario, Chico Ponce de León, Fernando, Robinson, Shenandoah, Zapotocky, Michal, Lassaletta, Alvaro, Huang, Annie, Hawkins, Cynthia E., Tabori, Uri, Bouffet, Eric, Bartels, Ute, Dirks, Peter B., Rutka, James T., Bader, Gary D., Reimand, Jüri, Goldenberg, Anna, Ramaswamy, Vijay, and Taylor, Michael D.

Published
2017
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28. Corrigendum to “Connecting molecular biomarkers, mineralogical composition, and microbial diversity from Mars analog lava tubes” [Sci. Total Environ. 913 (2024) 169583]

Author

Palma, Vera, González-Pimentel, José L., Jimenez-Morillo, Nicasio T., Sauro, Francesco, Gutiérrez-Patricio, Sara, De la Rosa, José M., Tomasi, Ilaria, Massironi, Matteo, Onac, Bogdan P., Tiago, Igor, González-Pérez, José A., Laiz, Leonila, Caldeira, Ana T., Martínez-Frías, Jesús, Cubero, Beatriz, and Miller, Ana Z.

Published
2024
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29. Crossiella, a Rare Actinomycetota Genus, Abundant in the Environment

Author

Martin-Pozas, Tamara, primary, Gonzalez-Pimentel, Jose Luis, additional, Jurado, Valme, additional, Laiz, Leonila, additional, Cañaveras, Juan Carlos, additional, Fernandez-Cortes, Angel, additional, Cuezva, Soledad, additional, Sanchez-Moral, Sergio, additional, and Saiz-Jimenez, Cesareo, additional

Published
2023
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30. Deep Brain Stimulation of the Anterior Nucleus of the Thalamus in Drug-Resistant Epilepsy in the MORE Multicenter Patient Registry

Author

Peltola, Jukka, Colon, Albert A., Pimentel, Jose, Coenen, Volker, Gil-Nagel, Antonio, Goncalves Ferreira, Antonio, Lehtimaki, Kai S., Ryvlin, Philippe, Taylor, Rod, Ackermans, Linda, Ardesch, Jacqueline, Bentes, Carla G., Bosak, Magdalena, Burneo, Jorge E., Chamadoira, Clara, Elger, Christian, Eross, Lorand, Fabo, Daniel, Faulkner, Howard, Gawlowicz, Jacek, Gharabaghi, Alireza, Iacoangeli, Maurizio, Janszky, Jozsef, Jarvenpaa, Soila H., Kaufmann, Elisabeth, Kho, Kuan H., Kumlien, Eva, Laufs, Helmut, Lettieri, Christian, Linhares, Paulo, Noachtar, Soheyl, Parrent, Andrew K., Pataraia, Ekaterina, Patel, Nikunj K., Peralta, Ana Rita, Racz, Attila, Campos, Alexandre Rainha A., Rego, Ricardo, Ricciuti, Riccardo, Rona, Sabine, Rouhl, Rob P. W., Schulze-Bonhage, Andreas, Schuurman, Rick, Sprengers, Mathieu, Sufianov, Albert, Temel, Yasin, Theys, Tom, Van Paesschen, Wim, Van Roost, Dirk, Vaz, Rui, Vonck, Kristl, Wagner, Louis, Zwemmer, Jack C., Abouihia, Abdallah, Brionne, Thomas, Gielen, Frans, Boon, Paul A. J. M., Peltola, Jukka, Colon, Albert A., Pimentel, Jose, Coenen, Volker, Gil-Nagel, Antonio, Goncalves Ferreira, Antonio, Lehtimaki, Kai S., Ryvlin, Philippe, Taylor, Rod, Ackermans, Linda, Ardesch, Jacqueline, Bentes, Carla G., Bosak, Magdalena, Burneo, Jorge E., Chamadoira, Clara, Elger, Christian, Eross, Lorand, Fabo, Daniel, Faulkner, Howard, Gawlowicz, Jacek, Gharabaghi, Alireza, Iacoangeli, Maurizio, Janszky, Jozsef, Jarvenpaa, Soila H., Kaufmann, Elisabeth, Kho, Kuan H., Kumlien, Eva, Laufs, Helmut, Lettieri, Christian, Linhares, Paulo, Noachtar, Soheyl, Parrent, Andrew K., Pataraia, Ekaterina, Patel, Nikunj K., Peralta, Ana Rita, Racz, Attila, Campos, Alexandre Rainha A., Rego, Ricardo, Ricciuti, Riccardo, Rona, Sabine, Rouhl, Rob P. W., Schulze-Bonhage, Andreas, Schuurman, Rick, Sprengers, Mathieu, Sufianov, Albert, Temel, Yasin, Theys, Tom, Van Paesschen, Wim, Van Roost, Dirk, Vaz, Rui, Vonck, Kristl, Wagner, Louis, Zwemmer, Jack C., Abouihia, Abdallah, Brionne, Thomas, Gielen, Frans, and Boon, Paul A. J. M.

Abstract

Background and Objectives The efficacy of deep brain stimulation of the anterior nucleus of the thalamus (ANT DBS) in patients with drug-resistant epilepsy (DRE) was demonstrated in the double-blind Stimulation of the Anterior Nucleus of the Thalamus for Epilepsy randomized controlled trial. The Medtronic Registry for Epilepsy (MORE) aims to understand the safety and longer-term effectiveness of ANT DBS therapy in routine clinical practice. Methods MORE is an observational registry collecting prospective and retrospective clinical data. Participants were at least 18 years old, with focal DRE recruited across 25 centers from 13 countries. They were followed for at least 2 years in terms of seizure frequency (SF), responder rate (RR), health-related quality of life (Quality of Life in Epilepsy Inventory 31), depression, and safety outcomes. Results Of the 191 patients recruited, 170 (mean [SD] age of 35.6 [10.7] years, 43% female) were implanted with DBS therapy and met all eligibility criteria. At baseline, 38% of patients reported cognitive impairment. The median monthly SF decreased by 33.1% from 15.8 at baseline to 8.8 at 2 years (p < 0.0001) with 32.3% RR. In the subgroup of 47 patients who completed 5 years of follow-up, the median monthly SF decreased by 55.1% from 16 at baseline to 7.9 at 5 years (p < 0.0001) with 53.2% RR. High-volume centers (>10 implantations) had 42.8% reduction in median monthly SF by 2 years in comparison with 25.8% in low-volume center. In patients with cognitive impairment, the reduction in median monthly SF was 26.0% by 2 years compared with 36.1% in patients without cognitive impairment. The most frequently reported adverse events were changes (e.g., increased frequency/severity) in seizure (16%), memory impairment (patient-reported complaint, 15%), depressive mood (patient-reported complaint, 13%), and epilepsy (12%). One definite sudden unexpected death in epilepsy case was reported. Discussion The MORE registry supports t

Published
2023
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31. Microclimate, airborne particles, and microbiological monitoring protocol for conservation of rock-art caves: The case of the world-heritage site La Garma cave (Spain)

Author

Universidad de Alicante. Departamento de Ciencias de la Tierra y del Medio Ambiente, Martin-Pozas, Tamara, Fernández Cortés, Ángel, Cuezva Robleño, Soledad, Jurado Lobo, Valme, Gonzalez-Pimentel, Jose Luis, Hermosin, Bernardo, Ontañón Peredo, Roberto, Arias, Pablo, Cañaveras, Juan C., Sánchez Moral, Sergio, Sáiz Jiménez, Cesáreo, Universidad de Alicante. Departamento de Ciencias de la Tierra y del Medio Ambiente, Martin-Pozas, Tamara, Fernández Cortés, Ángel, Cuezva Robleño, Soledad, Jurado Lobo, Valme, Gonzalez-Pimentel, Jose Luis, Hermosin, Bernardo, Ontañón Peredo, Roberto, Arias, Pablo, Cañaveras, Juan C., Sánchez Moral, Sergio, and Sáiz Jiménez, Cesáreo

Abstract

Cave heritage is often threatened by tourism or even scientific activities, which can lead to irreversible deterioration. We present a preventive conservation monitoring protocol to protect caves with rock art, focusing on La Garma Cave (Spain), a World Heritage Site with valuable archaeological materials and Palaeolithic paintings. This study assessed the suitability of the cave for tourist use through continuous microclimate and airborne particles monitoring, biofilm analysis, aerobiological monitoring and experimental visits. Our findings indicate several factors that make it inadvisable to adapt the cave for tourist use. Human presence and transit within the cave cause cumulative effects on the temperature of environmentally very stable and fragile sectors and significant resuspension of particles from the cave sediments. These environmental perturbations represent severe impacts as they affect the natural aerodynamic control of airborne particles and determine bacterial dispersal throughout the cave. This monitoring protocol provides part of the evidence to design strategies for sustainable cave management.

Published
2023

32. Crossiella, a Rare Actinomycetota Genus, Abundant in the Environment

Author

Universidad de Alicante. Departamento de Ciencias de la Tierra y del Medio Ambiente, Martin-Pozas, Tamara, Gonzalez-Pimentel, Jose Luis, Jurado Lobo, Valme, Laiz Trobajo, Leonila, Cañaveras, Juan C., Fernández Cortés, Ángel, Cuezva Robleño, Soledad, Sánchez Moral, Sergio, Sáiz Jiménez, Cesáreo, Universidad de Alicante. Departamento de Ciencias de la Tierra y del Medio Ambiente, Martin-Pozas, Tamara, Gonzalez-Pimentel, Jose Luis, Jurado Lobo, Valme, Laiz Trobajo, Leonila, Cañaveras, Juan C., Fernández Cortés, Ángel, Cuezva Robleño, Soledad, Sánchez Moral, Sergio, and Sáiz Jiménez, Cesáreo

Abstract

The genus Crossiella contains two species, C. equi, causing nocardioform placentitis in horses, and C. cryophila, an environmental bacterium. Apart from C. equi, which is not discussed here, environmental Crossiella is rarely reported in the literature; thus, it has not been included among “rare actinobacteria”, whose isolation frequency is very low. After C. cryophila, only five reports cover the isolation of Crossiella strains. However, the frequency of published papers on environmental Crossiella has increased significantly in recent years due to the extensive use of next-generation sequencing (NGS) and a huge cascade of data that has improved our understanding of how bacteria occur in the environment. In the last five years, Crossiella has been found in different environments (caves, soils, plant rhizospheres, building stones, etc.). The high abundance of Crossiella in cave moonmilk indicates that this genus may have an active role in moonmilk formation, as evidenced by the precipitation of calcite, witherite, and struvite in different culture media. This review provides an overview of environmental Crossiella, particularly in caves, and discusses its role in biomineralization processes and bioactive compound production.

Published
2023

33. Prognostic value of medulloblastoma extent of resection after accounting for molecular subgroup: a retrospective integrated clinical and molecular analysis

Author

Thompson, Eric M, Hielscher, Thomas, Bouffet, Eric, Remke, Marc, Luu, Betty, Gururangan, Sridharan, McLendon, Roger E, Bigner, Darell D, Lipp, Eric S, Perreault, Sebastien, Cho, Yoon-Jae, Grant, Gerald, Kim, Seung-Ki, Lee, Ji Yeoun, Rao, Amulya A Nageswara, Giannini, Caterina, Li, Kay Ka Wai, Ng, Ho-Keung, Yao, Yu, Kumabe, Toshihiro, Tominaga, Teiji, Grajkowska, Wieslawa A, Perek-Polnik, Marta, Low, David C Y, Seow, Wan Tew, Chang, Kenneth T E, Mora, Jaume, Pollack, Ian F, Hamilton, Ronald L, Leary, Sarah, Moore, Andrew S, Ingram, Wendy J, Hallahan, Andrew R, Jouvet, Anne, Fèvre-Montange, Michelle, Vasiljevic, Alexandre, Faure-Conter, Cecile, Shofuda, Tomoko, Kagawa, Naoki, Hashimoto, Naoya, Jabado, Nada, Weil, Alexander G, Gayden, Tenzin, Wataya, Takafumi, Shalaby, Tarek, Grotzer, Michael, Zitterbart, Karel, Sterba, Jaroslav, Kren, Leos, Hortobágyi, Tibor, Klekner, Almos, László, Bognár, Pócza, Tímea, Hauser, Peter, Schüller, Ulrich, Jung, Shin, Jang, Woo-Youl, French, Pim J, Kros, Johan M, van Veelen, Marie-Lise C, Massimi, Luca, Leonard, Jeffrey R, Rubin, Joshua B, Vibhakar, Rajeev, Chambless, Lola B, Cooper, Michael K, Thompson, Reid C, Faria, Claudia C, Carvalho, Alice, Nunes, Sofia, Pimentel, José, Fan, Xing, Muraszko, Karin M, López-Aguilar, Enrique, Lyden, David, Garzia, Livia, Shih, David J H, Kijima, Noriyuki, Schneider, Christian, Adamski, Jennifer, Northcott, Paul A, Kool, Marcel, Jones, David T W, Chan, Jennifer A, Nikolic, Ana, Garre, Maria Luisa, Van Meir, Erwin G, Osuka, Satoru, Olson, Jeffrey J, Jahangiri, Arman, Castro, Brandyn A, Gupta, Nalin, Weiss, William A, Moxon-Emre, Iska, Mabbott, Donald J, Lassaletta, Alvaro, Hawkins, Cynthia E, Tabori, Uri, Drake, James, Kulkarni, Abhaya, Dirks, Peter, Rutka, James T, Korshunov, Andrey, Pfister, Stefan M, Packer, Roger J, Ramaswamy, Vijay, and Taylor, Michael D

Published
2016
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34. Corrigendum to “Enhanced visible-light-driven photocatalytic degradation of acetaminophen over CeO2/I, K-codoped C3N4 heterojunction with tunable properties in simulated water matrix” [Sep. Purif. Technol. 272 (2021) 117567]

Author

Paragas, Larah Kriselle B., primary, Dang, Van Dien, additional, Shanker Sahu, Rama, additional, Garcia-Segura, Sergi, additional, de Luna, Mark Daniel G., additional, Pimentel, Jose Antonio I., additional, and Doong, Ruey-An, additional

Published
2023
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36. Molecular subgroups of atypical teratoid rhabdoid tumours in children: an integrated genomic and clinicopathological analysis

Author

Torchia, Jonathon, Picard, Daniel, Lafay-Cousin, Lucie, Hawkins, Cynthia E, Kim, Seung-Ki, Letourneau, Louis, Ra, Young-Shin, Ho, King Ching, Chan, Tiffany Sin Yu, Sin-Chan, Patrick, Dunham, Christopher P, Yip, Stephen, Ng, Ho-keung, Lu, Jian-Qiang, Albrecht, Steffen, Pimentel, José, Chan, Jennifer A, Somers, Gino R, Zielenska, Maria, Faria, Claudia C, Roque, Lucia, Baskin, Berivan, Birks, Diane, Foreman, Nick, Strother, Douglas, Klekner, Almos, Garami, Miklos, Hauser, Peter, Hortobágyi, Tibor, Bognár, Laszló, Wilson, Beverly, Hukin, Juliette, Carret, Anne-Sophie, Van Meter, Timothy E, Nakamura, Hideo, Toledano, Helen, Fried, Iris, Fults, Daniel, Wataya, Takafumi, Fryer, Chris, Eisenstat, David D, Scheineman, Katrin, Johnston, Donna, Michaud, Jean, Zelcer, Shayna, Hammond, Robert, Ramsay, David A, Fleming, Adam J, Lulla, Rishi R, Fangusaro, Jason R, Sirachainan, Nongnuch, Larbcharoensub, Noppadol, Hongeng, Suradej, Barakzai, Muhammad Abrar, Montpetit, Alexandre, Stephens, Derek, Grundy, Richard G, Schüller, Ulrich, Nicolaides, Theodore, Tihan, Tarik, Phillips, Joanna, Taylor, Michael D, Rutka, James T, Dirks, Peter, Bader, Gary D, Warmuth-Metz, Monika, Rutkowski, Stefan, Pietsch, Torsten, Judkins, Alexander R, Jabado, Nada, Bouffet, Eric, and Huang, Annie

Published
2015
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42. Recurrence patterns across medulloblastoma subgroups: an integrated clinical and molecular analysis

Author

Ramaswamy, Vijay, Remke, Marc, Bouffet, Eric, Faria, Claudia C, Perreault, Sebastien, Cho, Yoon-Jae, Shih, David J, Luu, Betty, Dubuc, Adrian M, Northcott, Paul A, Schüller, Ulrich, Gururangan, Sridharan, McLendon, Roger, Bigner, Darell, Fouladi, Maryam, Ligon, Keith L, Pomeroy, Scott L, Dunn, Sandra, Triscott, Joanna, Jabado, Nada, Fontebasso, Adam, Jones, David T W, Kool, Marcel, Karajannis, Matthias A, Gardner, Sharon L, Zagzag, David, Nunes, Sofia, Pimentel, José, Mora, Jaume, Lipp, Eric, Walter, Andrew W, Ryzhova, Marina, Zheludkova, Olga, Kumirova, Ella, Alshami, Jad, Croul, Sidney E, Rutka, James T, Hawkins, Cynthia, Tabori, Uri, Codispoti, Kari-Elise T, Packer, Roger J, Pfister, Stefan M, Korshunov, Andrey, and Taylor, Michael D

Published
2013
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43. Holistic Approach to the Restoration of a Vandalized Monument: The Cross of the Inquisition, Seville City Hall, Spain

Author

Universidad de Alicante. Departamento de Ciencias de la Tierra y del Medio Ambiente, Jurado Lobo, Valme, Cañaveras, Juan C., Gomez-Bolea, Antonio, Gonzalez-Pimentel, Jose Luis, Sánchez Moral, Sergio, Costa, Carlos, Sáiz Jiménez, Cesáreo, Universidad de Alicante. Departamento de Ciencias de la Tierra y del Medio Ambiente, Jurado Lobo, Valme, Cañaveras, Juan C., Gomez-Bolea, Antonio, Gonzalez-Pimentel, Jose Luis, Sánchez Moral, Sergio, Costa, Carlos, and Sáiz Jiménez, Cesáreo

Abstract

The Cross of the Inquisition, sculpted in 1903 and raised on a column with a fluted shaft and ornamented with vegetable garlands, is located in a corner of the Plateresque façade of the Seville City Hall. The Cross was vandalized in September 2019 and the restoration concluded in September 2021. A geological and microbiological study was carried out in a few small fragments. The data are consistent with the exposure of the Cross of the Inquisition to an urban environment for more than 100 years. During that time, a lichen community colonized the Cross and the nearby City Hall façades. The lichens, bryophytes and fungi colonizing the limestone surface composed an urban community, regenerated from the remains of the original communities, after superficial cleaning of the limestone between 2008 and 2010. This biological activity was detrimental to the integrity of the limestone, as showed by the pitting and channels, which evidence the lytic activity of organisms on the stone surface. Stone consolidation was achieved with Estel 1000. Preventol RI80, a biocide able to penetrate the porous limestone and active against bacteria, fungi, lichens, and bryophytes, was applied in the restoration.

Published
2022

50. Paracoccus onubensis Gutierrez-Patricio & Gonzalez-Pimentel & Miller & Hermosin & Saiz-Jimenez & Jurado 2021, SP. NOV

Author

Gutierrez-Patricio, Sara, Gonzalez-Pimentel, Jose L., Miller, Ana Zelia, Hermosin, Bernardo, Saiz-Jimenez, Cesareo, and Jurado, Valme

Subjects
Hemiptera, Insecta, Arthropoda, Pseudococcidae, Paracoccus onubensis, Animalia, Biodiversity, Paracoccus, Taxonomy
Abstract

DESCRIPTION OF PARACOCCUS ONUBENSIS SP. NOV. Paracoccus onubensis (o.nu′ ben.sis, N.L. masc. adj. onubensis, pertaining to Onuba, the Roman name of Huelva, the province where the organism was first isolated). Cells are facultatively anaerobic, non-motile, Gram-stainnegativeandnon-endospore-forming.Theyare 0.5–0.7µm×1.2– 1.8µm in diameter, grow in pairs or singly (Fig. S4). Colonies on marine agar are 0.5–1.3mm in diameter, circular, convex, smooth and have entire margins. Good growth at 10–37°C, optimal at 20–30°C and weak growth at 8 and 42°C. Tolerates up to 12% NaCl, with optimum growth within 3–5% (v/w) NaCl. Growth occurs at pH 5.0–9.0, with an optimum at pH 5.0–6.0. Catalase- and oxidase-positive. It grows heterotrophically with various carbon sources and chemoautotrophically with thiosulfate under aerobic conditions. D-Glucose,L-galactose, D -mannose,D-mannitol, N -acetylglucosamine, maltose, potassium gluconate, adipate, malate, citrate and phenylacetate can be utilized as carbon sources. Utilizes sodium nitrate, ammonium sulphate, sodium glutamate, casamino acids and peptone as sole nitrogen sources. Produces acid from D,L-arabinose, aesculin, D -fructose, D-fucose, D-galactose, D-glucose, D-mannose, D-ribose andD,L-xylose; weakly from D-adonitol,L-arabitol, L-fucose, glycerol, D-lyxose, maltose, melibiose, sucrose and trehalose. Negative for amygdalin, D-arabitol, arbutin, dulcitol, gentibiose, glycogen, inositol, inulin, lactose, melezitose, methyl α-D-glucopyranoside, methyl α-D-mannopyranoside, methyl β- D-xylopyranoside, N -acetylglucosamine, potassium gluconate, potassium 2-ketogluconate, potassium 5-ketogluconate, raffinose, L-ramnose, salicin, D-sorbitol, L-sorbose, starch, D -tagatose, turanose and xylitol. Reduces nitrate to nitrite. Hydrolyses aesculin and Tween 20, and does not hydrolyse DNA, casein or Tweens 40 and 80. Produces alkaline phosphatase, esterase (C4), esterase lipase (C8), leucine arylamidase, valine arylamidase, cystine arylamidase, acid phosphatase, naphthol- AS-BI-phosphohydrolase and α-glucosidase. Assimilates glucose, arabinose, mannose, mannitol, N -acetyl-glucosamine, maltose, potassium gluconate, adipic acid, malate, trisodium citrate and phenylacetic acid, but does not assimilate capric acid. The most abundant fatty acid is C 18:1 ω7 c. Ubiquinone-10 is the major respiratory quinone. The polar lipids are diphosphatidylglycerol, phosphatidylcholine, phosphatidylglycerol and an unidentified aminolipid, an unidentified glycolipid and unidentified polar lipid. The G+C content of the type strain is 60.3 mol%. The type strain, 1011MAR3 C25 T (=CECT 9092 T =LMG 29414 T), was isolated from white biofilms on the walls of the cave Gruta de las Maravillas, Aracena (Huelva, Spain)., Published as part of Gutierrez-Patricio, Sara, Gonzalez-Pimentel, Jose L., Miller, Ana Zelia, Hermosin, Bernardo, Saiz-Jimenez, Cesareo & Jurado, Valme, 2021, Paracoccus onubensis sp. nov., a novel alphaproteobacterium isolated from the wall of a show cave, pp. 1-10 in International Journal of Systematic and Evolutionary Microbiology (004942) (004942) 71 (8) on page 8, DOI: 10.1099/ijsem.0.004942, http://zenodo.org/record/6224160

Published
2021
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