1. Sputum induction for assessment of biomarkers in early respiratory drug development .
- Author
-
Lins R, Pillu H, Gheyle L, van Riel A, Lins M, and Vanhoutte F
- Subjects
- Humans, Reproducibility of Results, Asthma, Biomarkers chemistry, Drug Development, Sputum chemistry
- Abstract
Objective: To study the success rate and reproducibility of sputum induction (SI) in healthy subjects (HS) and asthma patients (AP)., Materials and Methods: 130 HSs/APs were recruited for early-phase studies to evaluate sputum biomarkers. SI and sample processing were performed according to standard protocols., Results: Adequate samples were obtained from 46% of HSs and 80% of APs. There was no difference between the groups with adequate and nonadequate samples. Differences between HS and AP groups were minor. Reproducibility was 56.0% in HSs and 90.6% in APs., Conclusion: Sputum induction for biomarker assessment in early drug development is feasible in HSs and APs, but only modestly reproducible in HSs. The technique is complex and time consuming. .
- Published
- 2019
- Full Text
- View/download PDF