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Sputum induction for assessment of biomarkers in early respiratory drug development .
- Source :
-
International journal of clinical pharmacology and therapeutics [Int J Clin Pharmacol Ther] 2019 Jan; Vol. 57 (1), pp. 20-23. - Publication Year :
- 2019
-
Abstract
- Objective: To study the success rate and reproducibility of sputum induction (SI) in healthy subjects (HS) and asthma patients (AP).<br />Materials and Methods: 130 HSs/APs were recruited for early-phase studies to evaluate sputum biomarkers. SI and sample processing were performed according to standard protocols.<br />Results: Adequate samples were obtained from 46% of HSs and 80% of APs. There was no difference between the groups with adequate and nonadequate samples. Differences between HS and AP groups were minor. Reproducibility was 56.0% in HSs and 90.6% in APs.<br />Conclusion: Sputum induction for biomarker assessment in early drug development is feasible in HSs and APs, but only modestly reproducible in HSs. The technique is complex and time consuming. .
Details
- Language :
- English
- ISSN :
- 0946-1965
- Volume :
- 57
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- International journal of clinical pharmacology and therapeutics
- Publication Type :
- Academic Journal
- Accession number :
- 30520723
- Full Text :
- https://doi.org/10.5414/CP203294