1. Sevoflurane (0.4 MAC) does not Influence Cerebral Compliance in Healthy Individuals
- Author
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Pfeiffer Pk, Fritz Zschiegner, H. I. Lorenz, Christoph Hörmann, Christian Kolbitsch, Arnulf Benzer, Michael Schocke, and Stephan Felber
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Adult ,Male ,Methyl Ethers ,Intracranial pathology ,Contrast Media ,Sevoflurane ,Cerebrospinal fluid ,Humans ,Medicine ,Prospective Studies ,Cerebrospinal Fluid ,Analysis of Variance ,Dose-Response Relationship, Drug ,medicine.diagnostic_test ,business.industry ,Brain ,Magnetic resonance imaging ,Compliance (physiology) ,Anesthesiology and Pain Medicine ,Cerebral hemodynamics ,Cerebrovascular Circulation ,Anesthesia ,Healthy individuals ,Anesthetics, Inhalation ,Anesthetic ,Surgery ,Neurology (clinical) ,business ,Magnetic Resonance Angiography ,medicine.drug - Abstract
The use of sevoflurane is favored for its rapid onset and offset of anesthesia as well as good intraoperative titratability of the anesthetic. With regard to neuroanesthesia, the reported effects of sevoflurane on cerebral hemodynamics and cerebrospinal fluid dynamics are inconsistent. We used phase-contrast magnetic resonance imaging measurement of systolic cerebrospinal fluid peak velocity (CSFVPeak) to evaluate the effect of sevoflurane on cerebral compliance in healthy individuals. During administration of 0.4 MAC sevoflurane, systolic CSFVPeak in the aqueduct of Sylvius remained unchanged, thereby indicating unaffected cerebral compliance: (CSFVPeak baseline: -3.1 +/- 1.0 cm/s vs. sevoflurane: -3.0 +/- 1.2 cm/s). We conclude that low-dose administration of sevoflurane does not influence cerebral compliance in healthy individuals, but the influence of coexisting intracranial pathology or comedications on cerebral compliance requires further clinical investigation.
- Published
- 2000
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