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Background: Hemoglobin, Albumin, Lymphocyte, and Platelet Score (HALP) is an accessible score that is easily reproducible from routine laboratory testing while also reflecting patients' immune-nutritional status. Along with other immuno-nutritional scores, such as the Prognostic Nutrition Index (PNI), HALP has been associated with a number of clinical and pathological features. The goal of our study was to evaluate the prognostic utility of HALP and PNI scores in testicular germ cell cancer (GCT) patients. Methods: This case-only study included 203 testicular GCT patients who were classified according to the disease stage and HALP and PNI cut-offs. Complete blood count and albumin concentration were routinely determined. Results: The values of HALP and PNI significantly differed among different clinical stages (p < 0.05). Moreover, they clearly exposed a significantly higher risk of advanced clinical stage development for those testicular GCT patients with lower values of HALP and PNI (p < 0.05). Finally, lower score levels were associated with larger tumor size (p < 0.05). Conclusion: Our investigation could provide evidence that specific immune-nutritional scores can help distinguish individuals diagnosed with testicular GCT who are more likely to be identified with advanced disease stages. [ABSTRACT FROM AUTHOR]

Background: Force-velocity (F-V) relationship models gained popularity as a tool for muscle mechanical assessment. However, it is not clear whether the validity of the F-V relationship parameters (maximal theoretical force [ F 0], velocity [ V 0] and power [ P max]) is affected using different load types: gravitational (W, rubber bands pulling the barbell downward), inertial (I, rubber bands pulling the barbell, which is equalized to the weight of the added plates upward), and combined (W + I, weight of the plates). Hypothesis: Load type would affect both the magnitude and validity of F-V relationship parameters. The highest magnitude and validity was expected for F 0 using a W, for V 0 using an I, and for P max using a W + I load. Study Design: Cross-sectional. Level of Evidence: Level 3. Methods: A total of 13 resistance-trained men (body mass, 87.7 ± 11.2 kg and body height, 183.9 ± 6.4 cm) performed bench press (BP) throws (BPTs) using 3 types of loads against 30 to 80 kg. The validity of F-V relationship parameters was explored with respect to the tests used traditionally for force (maximal voluntary contraction and 1-repetition maximum [1RM]), velocity (maximal velocity achieved during almost unloaded tasks), and power (BPT against the 50%1RM and medicine ball throws) assessment. Results: The W + I loading promoted the highest values of F 0 and P max, while the highest magnitude of V 0 was promoted by the I loading. The validity was acceptable for F 0 obtained using the 3 loading conditions with respect to the BP 1RM (r range, 0.30-0.83), and V 0 obtained using the I loading with respect to the stick throw (r = 0.54). Conclusion: The magnitude of the F-V relationship parameters is affected by load type, but their validity with respect to standardized tests is comparable, with the exception of the higher validity of V 0 when obtained using the I loading. Clinical Relevance: Any load type can be used for assessing F 0, while I load should be selected when assessing V 0. [ABSTRACT FROM AUTHOR]

While dental poly methyl methacrylate(PMMA) possesses distinctive qualities such as ease of fabrication, cost-effectiveness, and favorable physical and mechanical properties, these attributes alone are inadequate to impart the necessary impact strength and hardness. Consequently, pure PMMA is less suitable for dental applications. This research focused on the incorporation of Strontium titanate (SrTiO3-STO) and hybrid filler STO/Manganese oxide (MnO2) to improve impact resistance and hardness. The potential of STO in reinforcing PMMA is poorly investigated, while hybrid filler STO/MnO2 has not been presented yet. Differential scanning calorimetry is conducted in order to investigate the agglomeration influence on the PMMA glass transition temperature (Tg), as well as the leaching of residual monomer and volatile additives that could pose a threat to human health. It has been determined that agglomeration with 1 wt% loading had no influence on Tg, while the first scan revealed differences in evaporation of small molecules, in favor of composite PMMA-STO/MnO2, which showed the trapping potential of volatiles. Investigations of mechanical properties have revealed the significant influence of hybrid STO/MnO2 filler on microhardness and total absorbed impact energy, which were increased by 89.9% and 145.4%, respectively. Results presented in this study revealed the reinforcing potential of hybrid nanoparticles that could find application in other polymers as well. [ABSTRACT FROM AUTHOR]

Purpose: To test whether the force–velocity (F–V) relationship obtained during a specific single-stroke kayak test (SSKT) and during nonspecific traditional resistance-training exercises (bench press and prone bench pull) could discriminate between 200-m specialists and longer-distance (500- and 1000-m) specialists in canoe sprint. Methods: A total of 21 experienced male kayakers (seven 200-m specialists and 14 longer-distance specialists) participated in this study. After a familiarization session, kayakers came to the laboratory on 2 occasions separated by 48 to 96 hours. In a randomized order, kayakers performed the SSKT in one session and the bench press and bench pull tests in another session. Force and velocity outputs were recorded against 5 loads in each exercise to determine the F–V relationship and related parameters (maximum force, maximum velocity, F–V slope, and maximum power). Results: The individual F–V relationships were highly linear for the SSKT (r =.990 [.908,.998]), bench press (r =.993 [.974,.999]), and prone bench pull (r =.998 [.992, 1.000]). The F–V relationship parameters (maximum force, maximum velocity, and maximum power) were significantly higher for 200-m specialists compared with longer-distance specialists (all Ps ≤.047) with large effect sizes (≥0.94) revealing important practical differences. However, no significant differences were observed between 200-m specialists and longer-distance specialists in the F–V slope (P ≥.477). Conclusions: The F–V relationship assessed during both specific (SSKT) and nonspecific upper-body tasks (bench press and bench pull) may distinguish between kayakers specialized in different distances. [ABSTRACT FROM AUTHOR]

In this study, polycaprolactone (PCL), as a biocompatible polymer was functionalized by addition of medicinal plant extract‐ Achillea millefolium L. (yarrow). Nanofiber mats were fabricated from PCL solutions containing dry yarrow extract in four concentrations (5%, 10%, 15%, and 20% relative to the weight of the polymer) by using blend electrospinning method. The nanofibers were characterized for their biological, mechanical and drug release behavior. In vitro release of yarrow polyphenols from the electrospun PCL nanofibers over a period of 5 days showed the release of up to 98% of the total loaded polyphenols. The released polyphenols retained its antioxidant activity, which was determined by DPPH assay. Electrospun PCL/yarrow nanofiber mats exhibited the antibacterial effect against Staphylococcus aureus, but had no effect on the growth of Pseudomonas aeruginosa. All PCL/yarrow nanofiber mats had improved mechanical properties compared to the neat PCL nanofibers, as evident by an increase in Young's modulus of elasticity (up to 5.7 times), the tensile strength (up to 5.5 times), and the strain at break (up to 1.45 times). Based on our results, yarrow‐loaded PCL nanofiber mats appeared to be multi‐functional biomaterials suitable for the production of catheter‐coating materials, patches, or gauzes with antibacterial and antioxidant properties. [ABSTRACT FROM AUTHOR]