18 results on '"Perrin KL"'
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2. COMPARISON OF THREE MIDAZOLAM-BASED SEDATION PROTOCOLS IN BUDGERIGARS ( MELOPSITTACUS UNDULATUS ) AND BLACK-CHEEKED LOVEBIRDS ( AGAPORNIS NIGRIGENIS ).
- Author
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Abreu SA, Laursen SA, Perrin KL, Tahas SA, and Bertelsen MF
- Subjects
- Animals, Cross-Over Studies, Hypnotics and Sedatives pharmacology, Medetomidine pharmacology, Clinical Protocols, Agapornis, Melopsittacus, Midazolam pharmacology
- Abstract
This randomized, crossover study evaluated three sedation protocols administered subcutaneously in nine budgerigars ( Melopsittacus undulatus ) and nine black-cheeked lovebirds ( Agapornis nigrigenis ). All protocols included midazolam (5 mg/kg), combined with butorphanol (5 mg/kg) (BM), medetomidine (20 lg/kg) (MM), or alfaxalone (13 mg/kg) (AM). Mortalities from suspected cardiorespiratory arrest were observed when AM was used in lovebirds, even after reduction of alfaxalone dosage to 3 mg/kg, and therefore this protocol was excluded from further use in this species. Induction and recovery times were recorded and their quality assessed. Sedation depth and heart and respiratory rates were measured every 5 min and radiographic positioning was attempted at 10 and 20 min. At 30 min, midazolam and medetomidine were reversed with flumazenil (0.05 mg/kg, SC), and atipamezole (0.2 mg/kg, SC), respectively. MM consistently provided deep sedation in both species, with successful radiographic positioning at every attempt. As expected, heart rate was often lower with MM than with other protocols, but no associated complications were noted. In budgerigars, BM had the lowest radiographic positioning success rate (10 min: 5/9, 20 min: 3/9), whereas in lovebirds it provided significantly deeper sedation ( P < 0.001), allowing radiographic positioning in all subjects. In both species, BM provided the shortest recovery times. AM resulted in reliable radiographic positioning of all budgerigars at 10 min, but not at 20 min (5/ 9), and provided consistently poor recoveries. This study highlights how differently two psittacine species of similar size may react to the same sedation protocols. AM sedation cannot be fully reversed and produced significant undesirable effects, several of which have been previously reported with alfaxalone administration to avian species. The authors therefore caution against using alfaxalone-midazolam combinations in budgerigars and black-cheeked lovebirds. Both BM and MM provided reliable sedation in these species, and appear to be suitable alternatives to AM.
- Published
- 2024
- Full Text
- View/download PDF
3. BIOLOGICAL VARIATION OF HEMATOLOGY PARAMETERS AND CLINICAL APPLICATION IN AFRICAN ELEPHANTS ( LOXODONTA AFRICANA ).
- Author
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Browning GR, Kjelgaard-Hansen M, Howard LL, Keener L, LaFarga M, and Perrin KL
- Subjects
- Animals, Retrospective Studies, Elephants, Hematology, Herpesviridae, Herpesviridae Infections veterinary
- Abstract
Detailed knowledge of biological variation can facilitate accurate interpretation of clinical pathology parameters. A recent biological variation study in Asian elephants ( Elephas maximus ) found that hematology parameters had high individuality, which suggests that population-derived reference intervals may be an insensitive diagnostic tool. In elephant medicine, sensitive hematology-related diagnostics are crucial for clinical decision-making, particularly in elephants at risk for elephant endotheliotropic herpesvirus hemorrhagic disease (EEHV-HD). The objective of this study was to assess biological variation of hematology parameters in African elephants to determine whether population-derived reference intervals are a sensitive diagnostic tool for interpreting results and to provide a useful alternative. Eight healthy African elephants had blood collected under behavioral training every other week for 8 wk. Complete blood cell count (CBC) analysis was performed in duplicate to assess analytical variation. Previous methods were used to determine between-individual variation, within-individual variation, index of individuality, and reference change values (RCV). This study found that most hematology parameters displayed intermediate-to-high individuality, which suggests that alternatives to population-derived reference intervals are necessary to detect pathologic changes. To test the results of our biological variation data, a case of EEHV-HD was retrospectively evaluated. Individual normal values and calculated RCV detected a clinically significant monocytopenia, leukopenia, and thrombocytopenia associated with EEHV2 viremia. However, none of these parameters fell outside a population-derived reference interval. This study highlights the utility of biological variation in clinical decision-making and demonstrates that individual normal values and RCV may be important diagnostic tools for CBC interpretation in African elephants.
- Published
- 2024
- Full Text
- View/download PDF
4. Vesicular stomatitis virus in two species of rhinoceros at a California zoological park.
- Author
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Berlin ER, Kinney ME, Howard LL, Perrin KL, Rodriguez P, Kubiski SV, and Phair KA
- Subjects
- Animals, California epidemiology, Female, Male, Disease Outbreaks veterinary, Vesicular stomatitis New Jersey virus genetics, Vesicular stomatitis New Jersey virus isolation & purification, Vesicular Stomatitis virology, Vesicular Stomatitis pathology, Perissodactyla virology, Animals, Zoo
- Abstract
Objective: To describe an outbreak of vesicular stomatitis virus (VSV) in southern white rhinoceros (SWR; Ceratotherium simum simum) and greater one-horned rhinoceros (GOHR; Rhinoceros unicornis) at a safari park in San Diego, CA, from May to September 2023., Animals: 21 SWR and 5 GOHR in professionally managed care., Methods: Rhinoceros of both species presented with a range of clinical signs and severities. Lesion locations were categorized as cutaneous (coronary bands, heels and soles, limbs, ventrum, neck folds, and ears) and mucocutaneous (lips, nostrils, mucous membranes of the oral cavity, and vulva). Clinical signs included lethargy, lameness, difficulty with prehension, hyporexia to anorexia, and hypersalivation. Severely affected rhinoceros had clinical pathology findings consistent with systemic inflammation., Results: Vesicular stomatitis New Jersey virus was confirmed via PCR from swabs of lesions in 10/26 (38%) rhinoceros. Of these 10 confirmed cases, 9 (90%) were SWR and 1 (10%) was a GOHR. A further 6/26 (24%) were considered probable cases, and 10/26 (38%) were considered suspect cases based on clinical signs, but the inability to appropriately sample due to the housing environment precluded confirmation. Histopathology samples from 3 rhinoceros were consistent with VSV, and viral RNA was localized in histologic lesions via RNA in situ hybridization for 1 case. All rhinoceros survived infection despite severe systemic illness in 2 animals., Clinical Relevance: This case series describes the clinical appearance and progression of VSV in 2 rhinoceros species. To the authors' knowledge, this is the first report of VSV in a rhinoceros.
- Published
- 2024
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5. Coagulation Disorders, Testing, and Treatment in Exotic Animal Critical Care.
- Author
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Perrin KL
- Subjects
- Animals, Hemostasis, Fibrinolysis, Critical Care, Mammals, Animals, Exotic, Blood Coagulation Disorders diagnosis, Blood Coagulation Disorders therapy, Blood Coagulation Disorders veterinary
- Abstract
Despite poor recognition in the literature, exotic companion animals are affected by many diseases that can result in disordered coagulation and fibrinolysis. This article outlines current knowledge of hemostasis, common diagnostic tests and reviews reported diseases associated with coagulopathy in small mammals, bird and reptiles. A range of conditions affect platelets and thrombocytes, endothelium and blood vessels, and plasma clotting factors. Improved recognition and monitoring of hemostatic disorders will enable targeted therapy and improved case outcomes., (Copyright © 2023 Elsevier Inc. All rights reserved.)
- Published
- 2023
- Full Text
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6. Pharmacokinetics of intravenous propofol in southern white rhinoceros (Ceratotherium simum simum) after intramuscular etorphine-butorphanol-medetomidine-azaperone.
- Author
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Berlin ER, Kinney ME, Howard LL, Perrin KL, Phair KA, Clancy MM, Ferris RL, Knych HK, and Mama KR
- Subjects
- Female, Animals, Butorphanol, Azaperone pharmacology, Medetomidine pharmacology, Hypnotics and Sedatives pharmacology, Apnea drug therapy, Apnea veterinary, Perissodactyla physiology, Etorphine pharmacology, Propofol
- Abstract
Objective: To determine the pharmacokinetics of a single bolus of intravenous (IV) propofol after intramuscular administration of etorphine, butorphanol, medetomidine, and azaperone in 5 southern white rhinoceros to facilitate reproductive evaluations. A specific consideration was whether propofol would facilitate timely orotracheal intubation., Animals: 5 adult, female, zoo-maintained southern white rhinoceros., Procedures: Rhinoceros were administered etorphine (0.002 mg/kg), butorphanol (0.02 to 0.026 mg/kg), medetomidine (0.023 to 0.025 mg/kg), and azaperone (0.014 to 0.017 mg/kg) intramuscularly (IM) prior to an IV dose of propofol (0.5 mg/kg). Physiologic parameters (heart rate, blood pressure, respiratory rate, and capnography), timed parameters (eg, time to initial effects and intubation), and quality of induction and intubation were recorded following drug administration. Venous blood was collected for analysis of plasma propofol concentrations using liquid chromatography-tandem mass spectrometry at various time points after propofol administration., Results: All animals were approachable following IM drug administration, and orotracheal intubation was achieved at 9.8 ± 2.0 minutes (mean ±SD) following propofol administration. The mean clearance for propofol was 14.2 ± 7.7 ml/min/kg, the mean terminal half-life was 82.4 ± 74.4 minutes, and the maximum concentration occurred at 2.8 ± 2.9 minutes. Two of 5 rhinoceros experienced apnea after propofol administration. Initial hypertension, which improved without intervention, was observed., Clinical Relevance: This study provides pharmacokinetic data and insight into the effects of propofol in rhinoceros anesthetized using etorphine, butorphanol, medetomidine, and azaperone. While apnea was observed in 2 rhinoceros, propofol administration allowed for rapid control of the airway and facilitated oxygen administration and ventilatory support.
- Published
- 2023
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7. Retention and loss of PIT tags and surgically implanted devices in the Eurasian beaver.
- Author
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Mayer M, Lian M, Fuchs B, Robstad CA, Evans AL, Perrin KL, Greunz EM, Laske TG, Arnemo JM, and Rosell F
- Subjects
- Animal Welfare, Animals, Animals, Wild, Foreign-Body Reaction veterinary, Rodentia
- Abstract
Background: Passive integrated transponder devices (PIT tags) are a valuable tool for individual identification of animals. Similarly, the surgical implantation of transmitters and bio-loggers can provide useful data on animal location, physiology and behavior. However, to avoid unnecessary recapture and related stress of study animals, PIT tags and bio-loggers should function reliably for long periods of time. Here, we evaluated the retention of PIT tags, and of very high frequency (VHF) transmitters and bio-loggers that were either implanted subcutaneously or into the peritoneal cavity of Eurasian beavers (Castor fiber)., Results: Over a 21-year period, we implanted PIT tags in 456 individuals and failed to detect a PIT tag at recapture in 30 cases, consisting of 26 individuals (6% of individuals). In all instances, we were still able to identify the individual due to the presence of unique ear tag numbers and tail scars. Moreover, we implanted 6 VHFs, 36 body temperature loggers and 21 heart rate loggers in 28 individuals, and experienced frequent loss of temperature loggers (at least 6 of 23 recaptured beavers) and heart rate loggers (10 of 18 recaptured beavers). No VHFs were lost in 2 recaptured beavers., Conclusions: Possible causes for PIT tag loss (or non-detection) were incorrect implantation, migration of the tag within the body, a foreign body reaction leading to ejection, or malfunctioning of the tag. We speculate that logger loss was related to a foreign body reaction, and that loggers were either rejected through the incision wound or, in the case of temperature loggers, possibly adhered and encapsulated to intestines, and then engulfed by the gastro-intestinal tract and ejected. We discuss animal welfare implications and give recommendations for future studies implanting bio-loggers into wildlife., (© 2022. The Author(s).)
- Published
- 2022
- Full Text
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8. Retrospective review of 27 European cases of fatal elephant endotheliotropic herpesvirus-haemorrhagic disease reveals evidence of disseminated intravascular coagulation.
- Author
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Perrin KL, Kristensen AT, Bertelsen MF, and Denk D
- Subjects
- Animals, Disseminated Intravascular Coagulation pathology, Edema pathology, Hemorrhage pathology, Herpesviridae Infections pathology, Inclusion Bodies, Viral metabolism, Inflammation pathology, Lymph Nodes pathology, Organ Specificity, Retrospective Studies, Severity of Illness Index, Disseminated Intravascular Coagulation veterinary, Disseminated Intravascular Coagulation virology, Elephants virology, Hemorrhage veterinary, Hemorrhage virology, Herpesviridae physiology, Herpesviridae Infections veterinary, Herpesviridae Infections virology
- Abstract
Elephant endotheliotropic herpesvirus haemorrhagic disease (EEHV-HD) is widely acknowledged as the most common cause of mortality in young Asian elephants (Elephas maximus) in captivity. The objective of the current study was to perform a blinded, retrospective pathology review of European EEHV-HD fatalities, constituting the largest systematic assessment of EEHV-HD pathology to date. Findings between viral genotypes were compared with the aim to investigate if disseminated intravascular coagulation (DIC) could be substantiated as a significant complicating factor, thereby increasing the understanding of disease pathophysiology. Immunohistochemical staining confirmed endothelial cell (EC) damage and the presence of EC intranuclear inclusion bodies, demonstrating a direct viral cytopathic effect. Microthrombi were observed in 63% of cases in several organs, including lungs, which, together with widespread haemorrhage and thrombocytopenia reported in EEHV-HD case reports, supports the presence of overt DIC as a serious haemostatic complication of active EEHV infection. Death was attributed to widespread vascular damage with multi-organ dysfunction, including severe acute myocardial haemorrhage and subsequent cardiac failure. Systemic inflammation observed in the absence of bacterial infection may be caused by cytokine release syndrome. Findings reinforce the necessity to investigate cytokine responses and haemostatic status during symptomatic and asymptomatic EEHV viraemia, to potentially support the use of anti-inflammatory treatment in conjunction with anti-viral therapy and cardiovascular support.
- Published
- 2021
- Full Text
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9. BIOLOGICAL VARIATION OF HEMATOLOGY AND BIOCHEMISTRY PARAMETERS FOR THE ASIAN ELEPHANT ( ELEPHAS MAXIMUS ), AND APPLICABILITY OF POPULATION-DERIVED REFERENCE INTERVALS.
- Author
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Perrin KL, Kristensen AT, Gray C, Nielsen SS, Bertelsen MF, and Kjelgaard-Hansen M
- Subjects
- Animals, Animals, Zoo blood, Blood Chemical Analysis veterinary, Female, Hematologic Tests veterinary, Male, Ontario, Reference Values, Biological Variation, Individual, Elephants blood
- Abstract
The aim of this study was to objectively evaluate the biological variation of healthy Asian elephant ( Elephas maximus ) hematology and biochemistry parameters, therefore enabling evidence-based clinical decision-making to improve patient management. Ten clinically healthy elephants had blood samples collected weekly for 5 wk under standardized conditions. The analytical, between- and within-individual variation, index of individuality, and reference change values were calculated using previously reported methods. Large between-individual variation and small within-individual variation for almost all parameters indicated that individual normal values should be used for interpreting blood results from Asian elephants.
- Published
- 2020
- Full Text
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10. Extracting physiological information in experimental biology via Eulerian video magnification.
- Author
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Lauridsen H, Gonzales S, Hedwig D, Perrin KL, Williams CJA, Wrege PH, Bertelsen MF, Pedersen M, and Butcher JT
- Subjects
- Animals, Chick Embryo, Humans, Mice, Pulse instrumentation, Pulse Wave Analysis instrumentation, Ambystoma mexicanum physiology, Heart Rate, Physiology methods, Videotape Recording methods, Zebrafish physiology
- Abstract
Background: Videographic material of animals can contain inapparent signals, such as color changes or motion that hold information about physiological functions, such as heart and respiration rate, pulse wave velocity, and vocalization. Eulerian video magnification allows the enhancement of such signals to enable their detection. The purpose of this study is to demonstrate how signals relevant to experimental physiology can be extracted from non-contact videographic material of animals., Results: We applied Eulerian video magnification to detect physiological signals in a range of experimental models and in captive and free ranging wildlife. Neotenic Mexican axolotls were studied to demonstrate the extraction of heart rate signal of non-embryonic animals from dedicated videographic material. Heart rate could be acquired both in single and multiple animal setups of leucistic and normally colored animals under different physiological conditions (resting, exercised, or anesthetized) using a wide range of video qualities. Pulse wave velocity could also be measured in the low blood pressure system of the axolotl as well as in the high-pressure system of the human being. Heart rate extraction was also possible from videos of conscious, unconstrained zebrafish and from non-dedicated videographic material of sand lizard and giraffe. This technique also allowed for heart rate detection in embryonic chickens in ovo through the eggshell and in embryonic mice in utero and could be used as a gating signal to acquire two-phase volumetric micro-CT data of the beating embryonic chicken heart. Additionally, Eulerian video magnification was used to demonstrate how vocalization-induced vibrations can be detected in infrasound-producing Asian elephants., Conclusions: Eulerian video magnification provides a technique to extract inapparent temporal signals from videographic material of animals. This can be applied in experimental and comparative physiology where contact-based recordings (e.g., heart rate) cannot be acquired.
- Published
- 2019
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11. INVESTIGATION INTO CARDIOVASCULAR ASSESSMENT OF CAPTIVE ADULT SCARLET IBIS ( EUDOCIMUS RUBER ).
- Author
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Perrin KL, Willesen JL, Koch J, Langhorn R, Krogh AK, Saxmose Nielsen S, and Bertelsen MF
- Subjects
- Animals, Animals, Zoo physiology, Cross-Sectional Studies, Denmark, Echocardiography veterinary, Birds physiology, Cardiovascular Physiological Phenomena, Cardiovascular System anatomy & histology
- Abstract
Cardiovascular lesions are commonly diagnosed postmortem in scarlet ibis ( Eudocimus ruber ), but antemortem diagnosis is rare. The aim of this study was to evaluate the cardiovascular health of a zoo population (n = 44) of apparently healthy, adult, scarlet ibis. A cross-sectional study design was employed whereby each animal was manually restrained for physical examination, phlebotomy, and echocardiographic examination performed with a 12-MHz transducer and a ventromedial approach, and observed intervals were calculated for 12 parameters. Seven individuals from the study population had high left-sided mid-ventricular velocities (2.59-5.89 m/sec) compared with values in other species. Follow-up examination suggested that these mid-ventricular obstructive lesions were dynamic and transient in nature rather than caused by fixed lesions within the outflow tract and may therefore be associated with stress. Conscious echocardiography proved to be feasible, although, unsurprisingly, the stress response in nonhabituated birds appeared to increase blood flow velocities. Handling protocols likely have a significant effect on echocardiographic parameters and should be taken into consideration when interpreting findings. Serum cholesterol concentrations were generally high (7.4-13.0 mmol/L), and further work is required to investigate the relationship between circulating cholesterol and the development of atherosclerosis in scarlet ibis. Serum cardiac troponin I concentrations were measured, and four animals were identified with suspected elevated levels, likely indicative of myocardial damage., (© 2019 by American Association of Zoo Veterinarians.)
- Published
- 2019
- Full Text
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12. THROMBOELASTOGRAPHY IN THE HEALTHY ASIAN ELEPHANT ( ELEPHAS MAXIMUS): REFERENCE INTERVALS AND EFFECTS OF STORAGE.
- Author
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Perrin KL, Krogh AK, Kjelgaard-Hansen M, Howard L, Bochsen L, Kiso WK, Schmitt D, Kristensen AT, and Bertelsen MF
- Subjects
- Animals, Female, Male, Reference Values, Animals, Zoo, Elephants blood, Thrombelastography veterinary
- Abstract
Hemorrhagic disease associated with elephant endotheliotropic herpesvirus infection is the most-frequent cause of mortality in captive Asian elephants ( Elephas maximus). Survival relies on intensive monitoring of hemostatic status. Thromboelastography (TEG) utilizes whole blood samples containing all the blood components of hemostasis and is therefore a sensitive indicator of the clinical status in the patient. This study was performed to assess the practicability of TEG in Asian elephants in a zoo environment. Citrated stabilized whole blood samples were obtained from 44 healthy Asian elephants. Kaolin-activated TEG was performed on whole blood at 60 min and 24 hr postsampling (to replicate shipment to an external laboratory) as well as on freeze-thawed plasma samples, 12-14 mo postsampling. Reference intervals were calculated for fresh whole blood and freeze-thawed plasma samples. In the 24-hr analysis, storage artifacts, likely due to cellular degeneration, resulted in a hypercoagulable thromboelastogram and thus reduced sensitivity for detecting coagulopathies. Therefore, delayed analysis of whole blood samples is not recommended.
- Published
- 2018
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13. ALFAXALONE ANESTHESIA IN THE BENGALESE FINCH ( LONCHURA DOMESTICA).
- Author
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Perrin KL, Nielsen JB, Thomsen AF, and Bertelsen MF
- Subjects
- Adjuvants, Anesthesia administration & dosage, Adjuvants, Anesthesia pharmacology, Analgesics, Opioid administration & dosage, Analgesics, Opioid pharmacology, Animals, Butorphanol administration & dosage, Butorphanol pharmacology, Cross-Over Studies, Dose-Response Relationship, Drug, Drug Therapy, Combination, Female, Male, Midazolam administration & dosage, Midazolam pharmacology, Pregnanediones administration & dosage, Random Allocation, Anesthetics pharmacology, Finches, Pregnanediones pharmacology
- Abstract
The objective of this study was to evaluate the use of alfaxalone in a small passerine species. A dose-response trial was conducted whereby 10, 30, and 50 mg/kg alfaxalone was administered subcutaneously (SC) to 10 Bengalese finches ( Lonchura domestica) in a randomized complete crossover study design. Subsequently, a similar protocol was used to compare 30 mg/kg alfaxalone alone or combined with either 0.7 mg/kg midazolam or 1 mg/kg butorphanol SC. Induction and recovery times were recorded and depth of anesthesia monitored at 5-min intervals throughout each procedure. Functional oxygen saturation and pulse rates were measured with a pulse oximeter at 15 min after administration of the anesthetic agent(s). Dose-dependent decreases in induction time and prolongation of anesthetic duration were seen with increasing alfaxalone dosage. Alfaxalone combined with midazolam resulted in faster inductions, and the addition of both midazolam and butorphanol resulted in longer durations of anesthesia than alfaxalone alone. The addition of midazolam significantly decreased the pulse rate at 15 min compared with alfaxalone alone. Alfaxalone was found to be an effective agent for inducing anesthesia when administered subcutaneously, and no complications were observed. Increasing the dose, and combining with a benzodiazepine or opioid increased the duration of anesthesia with minimal or no effects on respiratory or pulse rates, within the dose range investigated.
- Published
- 2017
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14. Conjunctival mucinous adenocarcinoma in an ostrich (Struthio camelus).
- Author
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Perrin KL, Bertelsen MF, Bartholin H, Grøndahl C, and Heegaard S
- Subjects
- Adenocarcinoma, Mucinous therapy, Animals, Conjunctival Neoplasms therapy, Male, Neoplasm Recurrence, Local therapy, Adenocarcinoma, Mucinous veterinary, Bird Diseases therapy, Conjunctival Neoplasms veterinary
- Abstract
A 2-year-old male ostrich (Struthio camelus) presented with a rapidly growing soft tissue mass protruding from the ventromedial aspect of the right eye (OD). The initial physical examination revealed a soft tissue mass attached to the medial inferior conjunctiva. The mass was excised with cryosurgery, and the conjunctival tissue margins were treated with cryoablation. Histopathological examination diagnosed granulomatous inflammation associated with scattered acid-fast bacteria. The ostrich recovered uneventfully and appeared healthy until recurrence of a grossly similar mass 2 months later. Gross examination revealed a botryoid mass attached to the inferior palpebral conjunctiva and extending onto the palpebral aspect of the nictitating membrane. Euthanasia was selected, and the histological diagnosis of the second mass was a mixed mucinous adenocarcinoma; however, no acid-fast bacteria were seen. Granulomatous conjunctival lesions have been previously described in the ostrich, while, to the authors' knowledge, neoplastic conjunctival lesions have not. Neoplasia should be considered as a differential diagnosis for a rapidly recurring, granulomatous conjunctival mass in this species., (© 2016 American College of Veterinary Ophthalmologists.)
- Published
- 2017
- Full Text
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15. COMPARISON OF ETORPHINE-ACEPROMAZINE AND MEDETOMIDINE-KETAMINE ANESTHESIA IN CAPTIVE IMPALA (AEPYCEROS MELAMPUS).
- Author
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Perrin KL, Denwood MJ, Grøndahl C, Nissen P, and Bertelsen MF
- Subjects
- Acepromazine administration & dosage, Anesthetics, Combined administration & dosage, Anesthetics, Combined pharmacology, Anesthetics, Dissociative administration & dosage, Anesthetics, Dissociative pharmacology, Animals, Bicarbonates blood, Blood Pressure drug effects, Body Temperature drug effects, Dopamine Antagonists administration & dosage, Dopamine Antagonists pharmacology, Drug Synergism, Drug Therapy, Combination, Etorphine administration & dosage, Heart Rate drug effects, Hydrogen-Ion Concentration, Hypnotics and Sedatives administration & dosage, Hypnotics and Sedatives pharmacology, Ketamine administration & dosage, Lactic Acid blood, Medetomidine administration & dosage, Oxygen blood, Respiration drug effects, Acepromazine pharmacology, Anesthesia veterinary, Antelopes, Etorphine pharmacology, Ketamine pharmacology, Medetomidine pharmacology
- Abstract
Impala (Aepyceros melampus) are a notoriously difficult species to manage in captivity, and anesthesia is associated with a high risk of complications including mortality. The aim of this study was to compare an opioid-based protocol with an α-2 agonist-based protocol. Nine female impala were studied in a random cross-over design. Subjects received either an etorphine-acepromazine (EA) protocol: 15 μg/kg etorphine and 0.15 mg/kg acepromazine, or a medetomidine-ketamine (MK) protocol: 109 μg/kg medetomidine and 4.4 mg/kg ketamine on day 1. Anaesthesia was repeated 3 days later with the alternative protocol. Subjective assessments of the quality of induction, muscle relaxation, and recovery were made by a blinded observer. Objective monitoring included blood pressure, end-tidal CO2, regional tissue oxygenation, and blood gas analysis. EA provided a significantly quicker (mean EA, 7.17 mins; MK, 17.6 mins) and more-reliable (score range EA, 3-5; MK, 1-5) induction. Respiratory rates were lower for EA with higher end-tidal CO2, but no apnoea was observed. As expected, blood pressures with EA were lower, with higher heart rates; however, arterial oxygenation and tissue oxygenation were equal or higher than with the MK protocol. In conclusion, at these doses, EA provided superior induction and equivalent muscle relaxation and recovery with apparent improved oxygen tissue delivery when compared to MK.
- Published
- 2015
- Full Text
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16. 1978 Survey of educational programs in speech-language pathology and audiology.
- Author
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Perrin KL
- Subjects
- United States, Workforce, Audiology education, Speech-Language Pathology education
- Published
- 1979
17. Personal incomes in the speech-language-hearing profession.
- Author
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Perrin KL
- Subjects
- Adult, Female, Humans, Male, Audiology, Salaries and Fringe Benefits, Speech Therapy
- Published
- 1979
18. A comparative study of the effect of two time-alteration techniques on listener comprehension.
- Author
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Perrin KL and Lass NJ
- Subjects
- Adolescent, Adult, Female, Humans, Male, Middle Aged, Time Factors, Speech Intelligibility
- Abstract
The purpose of this investigation was to determine if listener comprehension is differentially affected by two different techniques of time alteration: the sampling method and the harmonic compression method. The Nelson-Denny Reading Test, consisting of 8 selections of scientific and literary content appropriate for college students with respect to interest and level of difficulty, was presented to 3 groups of 40 Ss each; each group was given the tape-recorded test after processing at one of the 3 speech rates, normal, half normal, or twice normal rate. Of the 8 selections on this test, 4 were processed by sampling using a VARISPEECH-I compressor/expander, and 4 were processed by harmonic compression using a Lockheed LM-312 Pitch Normalizer. There were of course some differences in listener comprehension as a function of rate, but within each of the rate conditions there were no significant differences as a function of method of time alteration. With the type of speech material used here, and within these rate conditions, these time alteration methods can be used interchangeably in such research.
- Published
- 1978
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