29 results on '"Peratoner, L"'
Search Results
2. Shiga Toxin–Producing Escherichia coli Infections Associated with Hemolytic Uremic Syndrome, Italy, 1988–2000
- Author
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Tozzi, A. E., Caprioli, A., Minelli, F., Gianviti, A., Petris, L., Edefonti, A., Giovanni Montini, Ferretti, A., Palo, T., Gaido, M., Rizzoni, G., Bettinelli, A., Capasso, G., Caringella, A., Coppo, R., Lama, G., Li Volti, S., Maffei, S., Maringhini, S., Miglietti, N., Pecoraro, C., Pela, I., Pennesi, M., Penza, R., Peratoner, L., Perfumo, F., Ratsche, I., Salvaggio, E., Setzu, C., Zacchello, G., Tozzi, Ae, Caprioli, A, Minelli, F, Gianviti, A, De Petris, L, Edefonti, A, Montini, G, Ferretti, A, De Palo, T, Gaido, M, Rizzoni, G, A., Bettinelli, Capasso, Giovambattista, Caringella, A, Coppo, R, Lama, G, Li Volti, S, Maffei, S, Maringhini, S, Miglietti, N, Pecoraro, C, Pela, I, Pennesi, M, Penza, R, Peratoner, L, Perfumo, F, Ratsche, I, Salvaggio, E, Setzu, C, and Zacchello, G.
- Subjects
Microbiology (medical) ,Serotype ,Adolescent ,Population ,lcsh:Medicine ,Escherichia coli O157 ,medicine.disease_cause ,Annual incidence ,Shiga Toxin ,Microbiology ,lcsh:Infectious and parasitic diseases ,fluids and secretions ,Shiga toxin-producing Escherichia coli ,Escherichia coli ,Humans ,Medicine ,HUS ,lcsh:RC109-216 ,Serotyping ,education ,Escherichia coli Infections ,laboratory diagnosis ,education.field_of_study ,biology ,business.industry ,Research ,Incidence ,Incidence (epidemiology) ,lcsh:R ,Shiga toxin ,Virology ,STEC ,Infectious Diseases ,Italy ,Child, Preschool ,Population Surveillance ,Hemolytic-Uremic Syndrome ,biology.protein ,hemolytic uremic syndrome ,bacteria ,epidemiology ,business - Abstract
The mean annual incidence of hemolytic uremic syndrome in persons
- Published
- 2003
3. Is antibiotic prophylaxis in children with vesicoureteral reflux effective in preventing pyelonephritis and renal scars? A randomized, controlled trial
- Author
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PENNESI M, TRAVAN L, PERATONER L, BORDUGO A, CATTANEO A, RONFANI L, MINISINI S, NORTH EAST ITALY PROPHYLAXIS IN VUR STUDY GROUP, VENTURA, ALESSANDRO, Pennesi, M, Travan, L, Peratoner, L, Bordugo, A, Cattaneo, A, Ronfani, L, Minisini, S, Ventura, Alessandro, and NORTH EAST ITALY PROPHYLAXIS IN VUR STUDY, Group
- Subjects
Male ,Vesico-Ureteral Reflux ,Pyelonephritis ,Anti-Infective Agents, Urinary ,Infant ,vesicoureteral reflux ,controlled trial ,randomized ,Anti-Bacterial Agents ,Cicatrix ,Child, Preschool ,Pediatrics, Perinatology and Child Health ,Trimethoprim, Sulfamethoxazole Drug Combination ,Humans ,Female ,Kidney Diseases - Abstract
OBJECTIVES. There has been intense discussion on the effectiveness of continuous antibiotic prophylaxis for children with vesicoureteral reflux, and randomized, controlled trials are still needed to determine the effectiveness of long-term antibiotics for the prevention of acute pyelonephritis. In this multicenter, open-label, randomized, controlled trial, we tested the effectiveness of antibiotic prophylaxis in preventing recurrence of pyelonephritis and avoiding new scars in a sample of children who were younger than 30 months and vesicoureteral reflux. METHODS. One hundred patients with vesicoureteral reflux (grade II, III, or IV) diagnosed with cystourethrography after a first episode of acute pyelonephritis were randomly assigned to receive antibiotic prophylaxis with sulfamethoxazole/trimethoprim or not for 2 years. The main outcome of the study was the recurrence of pyelonephritis during a follow-up period of 4 years. During follow-up, the patients were evaluated through repeated cystourethrographies, renal ultrasounds, and dimercaptosuccinic acid scans. RESULTS. The baseline characteristics in the 2 study groups were similar. There were no differences in the risk for having at least 1 pyelonephritis episode between the intervention and control groups. At the end of follow-up, the presence of renal scars was the same in children with and without antibiotic prophylaxis. CONCLUSIONS. Continuous antibiotic prophylaxis was ineffective in reducing the rate of pyelonephritis recurrence and the incidence of renal damage in children who were younger than 30 months and had vesicoureteral reflux grades II through IV.
- Published
- 2008
4. [Dyslipidemia and reduced fibrinolysis in a child with hemolytic-uremic syndrome]
- Author
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Cernecca, F, Peratoner, L, Simeone, R, Barbi, E, Cattin, Luigi, Cernecca, F, Peratoner, L, Simeone, R, Barbi, E, and Cattin, Luigi
- Abstract
PED MED CHIR
- Published
- 1995
5. Fosfomycin Trometamol versus Netiltnicin in Pediatric Urinary Tract Infections
- Author
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Peratoner, L., primary, Corrias, A., additional, Tumbarello, R., additional, Bassetti, D., additional, Varese, L. A., additional, Principi, N., additional, Del Bono, G. P., additional, and Fontana, P., additional
- Full Text
- View/download PDF
6. RE: BEHAVIORAL THERAPY FOR PRIMARY NOCTURNAL ENURESIS
- Author
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Pennesi, M., primary, Pitter, M., additional, Bordugo, A., additional, Minisini, S., additional, and Peratoner, L., additional
- Published
- 2004
- Full Text
- View/download PDF
7. Prophylaxis and Therapy of Glomerulonephritis in the Course of Anaphylactoid Purpura The Results of a Polycentric Clinical Trial
- Author
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Peratoner, L., primary, Longo, F., additional, Lepore, L., additional, and Freschi, P., additional
- Published
- 1990
- Full Text
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8. Fosfomycin Trometamol versus Netilmicin in Children’s Lower Urinary Tract Infections
- Author
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Principi, N., primary, Corda, R., additional, Bassetti, D., additional, Varese, L.A., additional, and Peratoner, L., additional
- Published
- 1990
- Full Text
- View/download PDF
9. Antibiotic treatment of acute pyelonephritis,La terapia antibiotica della pielonefrite acuta
- Author
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Federico Marchetti, Pennesi, M., Pecile, P., Ellero, S., Brondello, C., and Peratoner, L.
10. Dyslipidemia and reduced fibrinolysis in a child with hemolytic-uremic syndrome | Dislipidemia e ridotta fibrinolisi in un bambino con sindrome emolitico-uremica
- Author
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Cernecca, F., Peratoner, L., ROBERTO SIMEONE, Barbi, E., and Cattin, L.
11. AMMONIA NITROGEN IN " SMALL-FOR-DATES " NEWBORN BABIES
- Author
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Rubaltelli, F.F, primary and Peratoner, L, additional
- Published
- 1969
- Full Text
- View/download PDF
12. Risk factors for poor renal prognosis in children with hemolytic uremic syndrome
- Author
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Angela Caringella, Elio Salvaggio, Laura De Petris, Leopoldo Peratoner, Maurizio Gaido, Lucilla Ravà, Alberto Edefonti, Alfredo Caprioli, Rosanna Coppo, Alfonso Ferretti, Giovanni Montini, Giovambattista Capasso, Gianfranco Rizzoni, Rosa Penza, Salvatore Li Volti, Alessandra Gianviti, Carmen Setzu, Gianluigi Ardissino, Nunzia Miglietti, Salvatore Maffei, Carmine Pecoraro, Alberto Eugenio Tozzi, Graziella Zacchello, Ilse Ratsche, Alberto Bettinelli, Silvio Maringhini, Marco Pennesi, Francesco Perfumo, Ivana Pela, Giuliana Lama, Tommaso De Palo, Gianviti, A, Tozzi, Ae, DE PETRIS, L, Caprioli, A, Rava, L, Edefonti, A, Ardissino, G, Montini, G, Zacchello, G, Ferretti, A, Pecoraro, C, DE PALO, T, Caringella, A, Gaido, M, Coppo, R, Perfumo, F, Miglietti, N, Ratsche, I, Penza, R, Capasso, Giovambattista, Maringhini, S, LI VOLTI, S, Setzu, C, Pennesi, M, Bettinelli, A, Peratoner, L, Pela, I, Salvaggio, E, Lama, G, Maffei, S, and Rizzoni, G.
- Subjects
Nephrology ,Diarrhea ,Male ,medicine.medical_specialty ,Atypical hemolytic uremic syndrome ,Adolescent ,medicine.medical_treatment ,Gastroenterology ,Shiga Toxin ,Cohort Studies ,Leukocyte Count ,fluids and secretions ,Shiga toxin-producing Escherichia coli ,Central Nervous System Diseases ,Risk Factors ,Internal medicine ,medicine ,Humans ,Risk factor ,Age of Onset ,Child ,Escherichia coli Infections ,Proportional Hazards Models ,Prognostic factor ,business.industry ,Proportional hazards model ,Infant ,Classification ,medicine.disease ,Prognosis ,Long-term outcome ,Survival Analysis ,Hemolytic urenic syndrome ,Treatment Outcome ,Italy ,Child, Preschool ,Pediatrics, Perinatology and Child Health ,Immunology ,Hemolytic-Uremic Syndrome ,Plasmapheresis ,Female ,medicine.symptom ,Age of onset ,business ,Kidney disease - Abstract
Many factors have been proposed as predictors of poor renal prognosis in children with hemolytic uremic syndrome (HUS), but their role is still controversial. Our aim was to detect the most reliable early predictors of poor renal prognosis to promptly identify children at major risk of bad outcome who could eventually benefit from early specific treatments, such as plasmapheresis. Prognostic factors identifiable at onset of HUS were evaluated by survival analysis and a proportional hazard model. These included age at onset, prodromal diarrhea (D), leukocyte count, central nervous system (CNS) involvement, and evidence of Shiga toxin-producing Escherichia coli (STEC) infection. Three hundred and eighty-seven HUS cases were reported; 276 were investigated for STEC infection and 189 (68%) proved positive. Age at onset, leukocyte count, and CNS involvement were not associated with the time to recovery. Absence of prodromal D and lack of evidence of STEC infection were independently associated with a poor renal prognosis; only 34% of patients D(-)STEC(- )recovered normal renal function compared with 65%-76% of D(+)STEC(+), D(+)STEC(-) and D(-)STEC(+ )patients. In conclusion, absence of both D and evidence of STEC infection are needed to identify patients with HUS and worst prognosis, while D(-) but STEC(+) patients have a significantly better prognosis.
- Published
- 2003
13. Major COL4A5 gene rearrangements in patients with juvenile type Alport syndrome
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Gianfranco Rizzoni, M. Savi, L. Peratoner, Marisa Giani, Maria Laura Cossu, P. Riegler, Tauro Maria Neri, Francesco Scolari, Mirella Bruttini, Andrea Ballabio, Alessandra Grillo, Lucia Galli, M. Mileti, Mietta Meroni, P. Zanelli, Alessandra Renieri, Adalberto Sessa, Laura Massella, M. De Marchi, Renieri, A, Galli, L, Grillo, A, Bruttini, M, Neri, T, Zanelli, P, Rizzoni, G, Massella, L, Sessa, A, Meroni, M, Peratoner, L, Riegler, P, Scolari, F, Mileti, M, Giani, M, Cossu, M, Savi, S, Ballabio, Andrea, and DE MARCHI, M.
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Adult ,Male ,congenital, hereditary, and neonatal diseases and abnormalities ,Candidate gene ,DNA, Complementary ,X Chromosome ,Adolescent ,DNA Mutational Analysis ,Nephritis, Hereditary ,Gene mutation ,Biology ,Hybrid Cells ,urologic and male genital diseases ,Polymerase Chain Reaction ,Type IV collagen ,Exon ,Gene mapping ,Leiomyomatosis ,Gene duplication ,otorhinolaryngologic diseases ,medicine ,Humans ,Alport syndrome ,Age of Onset ,skin and connective tissue diseases ,Child ,Frameshift Mutation ,Genetics (clinical) ,Sequence Deletion ,Genetics ,Glomerulonephritis ,Exons ,Middle Aged ,medicine.disease ,female genital diseases and pregnancy complications ,Pedigree ,Phenotype ,Genes ,Italy ,Chromosomes, Human, Pair 2 ,Disease Progression ,Kidney Failure, Chronic ,Female ,Collagen - Abstract
Mutations in the COL4A5 gene, which encodes the a5 chain of type IV collagen, are found in a large fraction of patients with X-linked Alport syndrome. The recently discovered COL4A6, tightly linked and highly homologous to COL4A5, represents a second candidate gene for Alport syndrome. We analyzed 177 Italian Alport syndrome families by Southern blotting using cDNA probes from both COL4A5 and COL4A6. Nine unrelated families, accounting for 5% of the cases, were found to have a rearrangement in COL4A5. No rearrangements were found in COL4A6, with the exception of a deletion encompassing the 5' ends of both COL4A5 and COL4A6 genes in a patient with Alport syndrome and leiomyomatosis. COL4A5 rearrangements were all intragenic and included 1 duplication and 7 deletions. Polymerase chain reaction (PCR) analysis was carried out to characterize deletion and duplication boundaries and to predict the resulting protein abnormality. The two smallest deletions involved a single exon (exons 17 and 40, respectively), while the largest ones spanned exons 1 to 36. The clinical phenotype of patients in whom a rearrangement in COL4A5 was detected was severe, with progression to end-stage renal failure in juvenile age and hypoacusis occurring in most cases. These data have some important implications in the diagnosis of patients with Alport syndrome.
- Published
- 1995
14. Puberty is associated with increased deterioration of renal function in patients with CKD: data from the ItalKid Project.
- Author
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Ardissino G, Testa S, Daccò V, Paglialonga F, Viganò S, Felice-Civitillo C, Battaglino F, Bettinelli A, Bordugo A, Cecchetti V, De Pascale S, La Manna A, Li Volti S, Maringhini S, Montini G, Pennesi M, and Peratoner L
- Subjects
- Adolescent, Child, Child, Preschool, Cohort Studies, Female, Gonadal Steroid Hormones metabolism, Humans, Infant, Male, Renal Insufficiency, Chronic mortality, Renal Insufficiency, Chronic therapy, Sex Factors, Young Adult, Kidney physiology, Puberty physiology, Renal Insufficiency, Chronic physiopathology, Renal Replacement Therapy methods
- Abstract
Objective: To analyse the timing of end stage renal disease in children with chronic kidney disease (CKD)., Design: A population-based cohort study., Setting: A nationwide registry (ItalKid Project) collecting information on all patients with CKD aged <20 years., Patients: 935 children with CKD secondary to renal hypodysplasia with or without urologic malformation. In a subgroup of patients (n=40) detailed pubertal staging was analysed in relation to CKD progression., Main Outcome Measures: Kidney survival (KS) was estimated using renal replacement therapy (RRT) as the end-point. Puberty was staged by identifying the pubertal growth spurt., Results: A non-linear decline in the probability of KS was observed, with a steep decrease during puberty: the probability of RRT was estimated to be 9.4% and 51.8% during the first and second decades of life, respectively. A break-point in the KS curve was identified at 11.6 and 10.9 years of age in male and female patients, respectively., Conclusions: The present analysis suggests that puberty is associated with increased deterioration of renal function in CKD. The mechanism(s) underlying this unique and specific (to children) pattern of progression have not yet been identified, but it may be that sex hormones play a role in this puberty-related progression of CKD.
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- 2012
- Full Text
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15. Behavioral therapy for primary nocturnal enuresis.
- Author
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Pennesi M, Pitter M, Bordugo A, Minisini S, and Peratoner L
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- Adolescent, Child, Child, Preschool, Female, Follow-Up Studies, Humans, Male, Behavior Therapy, Enuresis therapy
- Abstract
Purpose: Recent studies suggest the efficacy of behavioral therapy for enuresis, even in cases of minor daytime voiding problems. We describe our experience with the clinical followup and behavioral therapy of children with primary enuresis., Materials and Methods: We followed 159 boys and 91 girls 5 to 17 years old with primary enuresis who were treated at 3 medical centers with a pediatric nephrology clinic during the last 3 years. A detailed voiding history was obtained. Each child was treated with a bladder training session, including an explanation of the enuretic process, daily diary recording and training to recognize bladder distention and increase voiding frequency., Results: A total of 226 children (90%) presented with 1 or more symptoms of bladder maturation delay and 13% reported behavioral constipation. Of the patients 185 (74%) completed the proposed treatment, including 111 (60%) who reported a positive and 21 (11%) who reported a partial response. In 53 children (29%) the treatment failed., Conclusions: Most children with enuresis have daytime symptoms when an accurate history is recorded. As shown by our data, the efficacy of behavioral therapy is comparable to that of desmopressin or alarm therapy but it requires good compliance of the child with the therapeutic plan. Age is not a determining factor in the success rate.
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- 2004
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16. Risk factors for poor renal prognosis in children with hemolytic uremic syndrome.
- Author
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Gianviti A, Tozzi AE, De Petris L, Caprioli A, Ravà L, Edefonti A, Ardissino G, Montini G, Zacchello G, Ferretti A, Pecoraro C, De Palo T, Caringella A, Gaido M, Coppo R, Perfumo F, Miglietti N, Ratsche I, Penza R, Capasso G, Maringhini S, Li Volti S, Setzu C, Pennesi M, Bettinelli A, Peratoner L, Pela I, Salvaggio E, Lama G, Maffei S, and Rizzoni G
- Subjects
- Adolescent, Age of Onset, Central Nervous System Diseases complications, Child, Child, Preschool, Cohort Studies, Diarrhea epidemiology, Escherichia coli Infections complications, Escherichia coli Infections epidemiology, Escherichia coli Infections metabolism, Female, Hemolytic-Uremic Syndrome pathology, Humans, Infant, Italy epidemiology, Leukocyte Count, Male, Prognosis, Proportional Hazards Models, Risk Factors, Shiga Toxin metabolism, Survival Analysis, Treatment Outcome, Hemolytic-Uremic Syndrome epidemiology
- Abstract
Many factors have been proposed as predictors of poor renal prognosis in children with hemolytic uremic syndrome (HUS), but their role is still controversial. Our aim was to detect the most reliable early predictors of poor renal prognosis to promptly identify children at major risk of bad outcome who could eventually benefit from early specific treatments, such as plasmapheresis. Prognostic factors identifiable at onset of HUS were evaluated by survival analysis and a proportional hazard model. These included age at onset, prodromal diarrhea (D), leukocyte count, central nervous system (CNS) involvement, and evidence of Shiga toxin-producing Escherichia coli (STEC) infection. Three hundred and eighty-seven HUS cases were reported; 276 were investigated for STEC infection and 189 (68%) proved positive. Age at onset, leukocyte count, and CNS involvement were not associated with the time to recovery. Absence of prodromal D and lack of evidence of STEC infection were independently associated with a poor renal prognosis; only 34% of patients D(-)STEC(- )recovered normal renal function compared with 65%-76% of D(+)STEC(+), D(+)STEC(-) and D(-)STEC(+ )patients. In conclusion, absence of both D and evidence of STEC infection are needed to identify patients with HUS and worst prognosis, while D(-) but STEC(+) patients have a significantly better prognosis.
- Published
- 2003
- Full Text
- View/download PDF
17. Different clinical presentations of pyelonephritis in children with and without vesicoureteral reflux: an Italian Multicenter Study.
- Author
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Pennesi M, Salvatore CM, and Peratoner L
- Subjects
- Child, Preschool, Female, Humans, Infant, Infant, Newborn, Italy, Male, Prospective Studies, Pyelonephritis complications, Radiography, Vesico-Ureteral Reflux complications, Pyelonephritis diagnostic imaging
- Published
- 1998
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- View/download PDF
18. Major COL4A5 gene rearrangements in patients with juvenile type Alport syndrome.
- Author
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Renieri A, Galli L, Grillo A, Bruttini M, Neri T, Zanelli P, Rizzoni G, Massella L, Sessa A, Meroni M, Peratoner L, Riegler P, Scolari F, Mileti M, Giani M, Cossu M, Savi M, Ballabio A, and De Marchi M
- Subjects
- Adolescent, Adult, Age of Onset, Child, Chromosomes, Human, Pair 2 genetics, Collagen classification, DNA Mutational Analysis, DNA, Complementary genetics, Disease Progression, Exons genetics, Female, Frameshift Mutation, Genes, Humans, Hybrid Cells, Italy epidemiology, Kidney Failure, Chronic epidemiology, Kidney Failure, Chronic etiology, Leiomyomatosis genetics, Male, Middle Aged, Nephritis, Hereditary classification, Nephritis, Hereditary diagnosis, Nephritis, Hereditary epidemiology, Pedigree, Phenotype, Polymerase Chain Reaction, Collagen genetics, Nephritis, Hereditary genetics, Sequence Deletion, X Chromosome genetics
- Abstract
Mutations in the COL4A5 gene, which encodes the a5 chain of type IV collagen, are found in a large fraction of patients with X-linked Alport syndrome. The recently discovered COL4A6, tightly linked and highly homologous to COL4A5, represents a second candidate gene for Alport syndrome. We analyzed 177 Italian Alport syndrome families by Southern blotting using cDNA probes from both COL4A5 and COL4A6. Nine unrelated families, accounting for 5% of the cases, were found to have a rearrangement in COL4A5. No rearrangements were found in COL4A6, with the exception of a deletion encompassing the 5' ends of both COL4A5 and COL4A6 genes in a patient with Alport syndrome and leiomyomatosis. COL4A5 rearrangements were all intragenic and included 1 duplication and 7 deletions. Polymerase chain reaction (PCR) analysis was carried out to characterize deletion and duplication boundaries and to predict the resulting protein abnormality. The two smallest deletions involved a single exon (exons 17 and 40, respectively), while the largest ones spanned exons 1 to 36. The clinical phenotype of patients in whom a rearrangement in COL4A5 was detected was severe, with progression to end-stage renal failure in juvenile age and hypoacusis occurring in most cases. These data have some important implications in the diagnosis of patients with Alport syndrome.
- Published
- 1995
- Full Text
- View/download PDF
19. [Dyslipidemia and reduced fibrinolysis in a child with hemolytic-uremic syndrome].
- Author
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Cernecca F, Peratoner L, Simeone R, Barbi E, and Cattin L
- Subjects
- Blood Coagulation Tests, Child, Preschool, Fatty Acids, Omega-3 therapeutic use, Female, Hemolytic-Uremic Syndrome diagnosis, Humans, Hypercholesterolemia drug therapy, Hypertriglyceridemia drug therapy, Kidney diagnostic imaging, Thrombosis complications, Thrombosis diagnostic imaging, Tomography, X-Ray Computed, Blood Coagulation Disorders complications, Hemolytic-Uremic Syndrome etiology, Hypercholesterolemia complications, Hypertriglyceridemia complications
- Abstract
Many pathogenetic factors may enhance coagulation process and induce thrombosis. The Authors report a case of hemolytic-uremic syndrome, with marked evidence of macroscopic kidney thrombotic involvement, in which an important dyslipidemia (hypertriglyceridemia and hypercholesterolemia) was detected during the phase of clinical improvement. These findings, and the contemporary marked reduction of fibrinolytic activity, seem to be relevant pathogenetic factors in this case. The treatment with polyunsaturated fatty acids Omega 3 may have been helpful in modifying these serum abnormalities and maybe could have brought to the clinical improvement.
- Published
- 1995
20. Clinical outcome of fetal uropathy. I. Predictive value of prenatal echography positive for obstructive uropathy.
- Author
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Paduano L, Giglio L, Bembi B, Peratoner L, D'Ottavio G, and Benussi G
- Subjects
- Female, Humans, Hydronephrosis diagnostic imaging, Kidney abnormalities, Kidney diagnostic imaging, Kidney Diseases, Cystic diagnostic imaging, Predictive Value of Tests, Pregnancy, Fetal Diseases diagnostic imaging, Kidney Diseases diagnostic imaging, Ultrasonography, Prenatal
- Abstract
Clinical followup was performed in 73 neonates with a prenatal echographic suspicion of uropathy. Of 42 patients with a prenatal suspicion of unilateral hydronephrosis only 15 had pathological obstruction and 2 had multicystic dysplastic kidneys. Among 10 infants with a prenatal suspicion of bilateral hydronephrosis only 1 had true bilateral obstruction and 2 had unilateral obstruction. In 2 patients hydroureteronephrosis seen on prenatal echography was due to massive bilateral vesicoureteral reflux. In this group there was also a multicystic dysplastic kidney and 1 patient with bilateral cystic dysplasia. There was a prenatal suspicion of cystic disease in 8 infants. Postnatally, diagnosis was multicystic dysplastic kidney in 2 patients and a simple renal cyst in 4. The remaining 2 neonates had obstructive uropathy. Finally, of 13 neonates with a prenatal suspicion of anatomical-echo-structural abnormalities a definitive abnormality could be established in only 8. The predictive value of prenatal echography positive for obstructive uropathy was 34.6%.
- Published
- 1991
- Full Text
- View/download PDF
21. Clinical outcome of fetal uropathy. II. Sensitivity of echography for prenatal detection of obstructive pathology.
- Author
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Paduano L, Giglio L, Bembi B, Peratoner L, and Benussi G
- Subjects
- Child, Preschool, Female, Humans, Infant, Infant, Newborn, Male, Pregnancy, Sensitivity and Specificity, Urologic Diseases diagnostic imaging, Vesico-Ureteral Reflux diagnostic imaging, Fetal Diseases diagnostic imaging, Hydronephrosis diagnostic imaging, Ultrasonography, Prenatal
- Abstract
Among 8,579 neonates born between February 1, 1981 and March 31, 1987, and cleared by prenatal sonography for significant urinary tract abnormality 158 subsequently were hospitalized because of signs or symptoms of urinary tract disease, predominantly urinary tract infection. Evaluation of these 158 patients revealed 24 with vesicoureteral reflux, 7 with duplicated systems (2 of which showed reflux), 1 with the syndrome of Fraley, 1 with pyelectasis and 5 with mild hydronephrosis (3 secondary to reflux and 2 with diethylenetriaminepentaacetic acid renal scans considered to be nonobstructed). There was no incidence of significant obstructive uropathy that had been missed by the previous prenatal sonography and that surfaced subsequently to cause morbidity in this series. The principal disorder of the urinary tract that may fail prenatal investigation is vesicoureteral reflux.
- Published
- 1991
- Full Text
- View/download PDF
22. [Neonatal hypoxic-ischemic nephropathy and urinary diagnostic indices: the utility of measuring tubular enzymes (NAG and AAP)].
- Author
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Bertotti A, De Marchi S, Brovedani P, Gaeta G, Peratoner L, and Mangiarotti MA
- Subjects
- CD13 Antigens, Creatinine urine, Humans, Infant, Newborn, Infant, Premature, Infant, Small for Gestational Age, Acetylglucosaminidase urine, Aminopeptidases urine, Clinical Enzyme Tests, Hypoxia diagnosis, Ischemia diagnosis, Kidney blood supply, Kidney Diseases diagnosis, Kidney Tubules enzymology
- Abstract
Feto-neonatal hypoxia can cause a functional kidney impairment, which is often temporary and not clinically overt, but sometimes leading to acute renal failure. Hypoxic stress may result in a tubulo-interstitial damage, and kidney tubular enzymes determination has proved to be an easy, early, and non invasive method to define a tubular interstitial lesion. A major target of nephrotoxicity is the proximal tubular cell: alterations in brush-border membrane and cytoplasm result in increased turnover processes in the kidney cortex, following by a corresponding increased excretion of alanine-aminopeptidase (AAP) and N-acetyl-glucosaminidase (NAG) from the proximal tubular cells, long before glomerular or tubular functions are impaired. AAP and NAG excretion is directly correlated with the strength and the duration of toxic alteration of the proximal tubule. NAG and AAP have been already studied in the adults and the children; they have been chosen for this investigation with a double aim: 1) to define the amount of their urinary excretion in relation with gestational age at birth; 2) to evaluate if in the newborn, independently of the gestational age, their urinary concentration may be increased by ischaemic conditions caused by hypoxia. We studied 52 healthy newborns (7 preterm of 33-36 weeks and 45 full-term) and 16 newborns with feto-neonatal hypoxia (8 preterm of 26-36 weeks and full-term) at the forth day of life. Urinary NAG and AAP were assayed by colorimetric methods and the results expressed as mU/mg. creatininuria.(ABSTRACT TRUNCATED AT 250 WORDS)
- Published
- 1990
23. [Neutropenia caused by low-dose trimethoprim-sulfamethoxazole in children with chronic pathology of the urinary tract].
- Author
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De Manzini A, Peratoner L, and Lepore L
- Subjects
- Adolescent, Child, Child, Preschool, Chronic Disease, Drug Evaluation, Female, Humans, Infant, Leucovorin therapeutic use, Male, Neutropenia prevention & control, Trimethoprim, Sulfamethoxazole Drug Combination administration & dosage, Trimethoprim, Sulfamethoxazole Drug Combination therapeutic use, Agranulocytosis chemically induced, Neutropenia chemically induced, Trimethoprim, Sulfamethoxazole Drug Combination adverse effects, Urinary Tract Infections prevention & control
- Abstract
Neutropenia is the most common hematologic abnormality detected as consequence of Trimethoprim Sulfamethoxazole (TMP-SMX) therapy. Its incidence is evaluated in 27 children affected by urinary tract anomalies and treated with low doses of TMP SMX (2 + 10 mg/kg/die) for more than one month. A slight neutropenia was detected in 8 children (6 of these were in their first two years of life). In all the 27 cases a supplementation of folinic acid was started: a significant increase of PMN count was noted in all cases. Neutropenia can also appear after low (prophylactic) dosage of TMP-SMX, and can be prevented by concomitant administration of folinic acid.
- Published
- 1990
24. [Radiologic and urodynamic aspects of the myelodysplastic urethra].
- Author
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Boccafoschi C, Peratoner L, and Carini C
- Subjects
- Adolescent, Child, Child, Preschool, Female, Humans, Infant, Male, Radiography, Urethra diagnostic imaging, Neural Tube Defects physiopathology, Urethra physiopathology, Urodynamics
- Published
- 1986
25. [Eosinophiluria as a simple diagnostic test of penicillin nephropathy (author's transl)].
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Pocecco M, Lepore L, and Peratoner L
- Subjects
- Ampicillin adverse effects, Child, Preschool, Humans, Methicillin adverse effects, Nephritis, Interstitial chemically induced, Eosinophils, Kidney Diseases chemically induced, Penicillins adverse effects, Urine cytology
- Published
- 1981
26. Evaluation of kidney growth in vesico-ureteral reflux.
- Author
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Peratoner L, Messi G, and Fonda E
- Subjects
- Child, Humans, Vesico-Ureteral Reflux surgery, Kidney growth & development, Vesico-Ureteral Reflux physiopathology
- Abstract
The parenchymal growth of 80 kidneys with vesicoureteral reflux (VUR), 50 of them surgically corrected, has been evaluated by calculating the ratio between bipolar thickness (BT) and the kidney length (KL), as measured radiographically. We consider this ratio provides a more precise evaluation of the morphologic and functional state of the refluxing kidney as it corresponded closely with the planimetric measurement of the area of renal parenchyma (ARP) in the 12 kidneys where this has also been calculated. Eighteen out of 30 medically treated refluxing kidneys showed a BT/KL ratio inferior to the 2 SD value for age at the time of diagnosis. A worsening BT/KL ratio has been observed in 6 out of 30 kidneys in which reflux ceased spontaneously and in 11 out of 50 which have been corrected surgically. The unfavourable outcome, as far as this parameter is concerned, in the medically treated cases seems to be due to the recurrence of urinary tract infection (UTI); while there is non so clear explanation for it in cases which have been surgically corrected.
- Published
- 1984
27. Epidemiology of urinary tract infections and vesico-ureteral reflux in children.
- Author
-
Messi G, Peratoner L, Paduano L, and Marchi AG
- Subjects
- Adolescent, Child, Child, Preschool, Cross-Sectional Studies, Female, Humans, Infant, Italy, Male, Cystitis epidemiology, Pyelonephritis epidemiology, Vesico-Ureteral Reflux epidemiology
- Abstract
The purpose of this study was to assess the incidence of symptomatic urinary tract infection (U.T.I.) and malformations, such as vesico-ureteral reflux (V.U.R.), in the Trieste area. Data were collected in the framework of a survey based on the application of a protocol on urinary infections between 1979 and 1983. The U.T.I. incidence was found to be 1.38% of the 0-14-year-old residents, with a higher frequency in females (2.36%) than in males (0.46%). As regards V.U.R., the incidence in the population studied turned out to be 0.25%, with a females/males ratio of 4:1. Striking differences in incidence data were observed according to the age of U.T.I. and V.U.R. diagnosis and to the infection level (cystitis or pyelonephritis). The incidence of renal scarring resulted to be extremely low, which can be ascribed to the early diagnosis in our cases.
- Published
- 1989
28. [Immunological study of glomerular nephropathies in childhood].
- Author
-
Peratoner L, Zacchello G, and Antonutto G
- Subjects
- Biopsy, Child, Child, Preschool, Glomerulonephritis therapy, Humans, Immunotherapy, Kidney Glomerulus immunology, Kidney Glomerulus pathology, Glomerulonephritis immunology, Immunoglobulins analysis
- Published
- 1978
29. [Urinary secretion of alpha-glucosidase, N-acetyl-glucosaminidase and alanine-aminopeptidase in the healthy newborn infant at term].
- Author
-
Bertotti A, Mangiarotti MA, Peratoner L, Stormi M, D'Avanzo R, De Marchi S, and Barbone F
- Subjects
- CD13 Antigens, Female, Humans, Male, Acetylglucosaminidase urine, Aminopeptidases urine, Hexosaminidases urine, Infant, Newborn urine, alpha-Glucosidases urine
- Published
- 1987
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