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89 results on '"Pennisi, D."'

2. Effectiveness of topical use of Lietofix® in wound healing after pilonidalis sinus excision: a multicenter study by the Italian Society of Colorectal Surgery (SICCR)

Author

SICCR PILONIDALIS STUDY GROUP, Giannini, I., Andreoli, R., Bianchi, F. P., Cavallaro, V., Corno, F., Geccherle, A., Ghiglione, F., Legnaro, A., Losacco, L., Marola, S., Orlandi, S., Pecorella, G., Pennisi, D., Perinotti, R., Poli, F., Pozzo, M., Pulzato, L., Schembari, E., Tafuri, S., Tegon, G., Tricomi, N., Velci, L., Vittadello, F., and Santoro, G. A.

Published
2019
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6. 30-day morbidity and mortality of sleeve gastrectomy, Roux-en-Y gastric bypass and one anastomosis gastric bypass: a propensity score-matched analysis of the GENEVA data

Author

Singhal R., Cardoso V. R., Wiggins T., Super J., Ludwig C., Gkoutos G. V., Mahawar K., Pedziwiatr M., Major P., Zarzycki P., Pantelis A., Lapatsanis D. P., Stravodimos G., Matthys C., Focquet M., Vleeschouwers W., Spaventa A. G., Zerrweck C., Vitiello A., Berardi G., Musella M., Sanchez-Meza A., Cantu F. J., Mora F., Cantu M. A., Katakwar A., Reddy D. N., Elmaleh H., Hassan M., Elghandour A., Elbanna M., Osman A., Khan A., layani L., Kiran N., Velikorechin A., Solovyeva M., Melali H., Shahabi S., Agrawal A., Shrivastava A., Sharma A., Narwaria B., Narwaria M., Raziel A., Sakran N., Susmallian S., Karagoz L., Akbaba M., Piskin S. Z., Balta A. Z., Senol Z., Manno E., Iovino M. G., Qassem M., Arana-Garza S., Povoas H. P., Vilas-Boas M. L., Naumann D., Li A., Ammori B. J., Balamoun H., Salman M., Nasta A. M., Goel R., Sanchez-Aguilar H., Herrera M. F., Abou-mrad A., Cloix L., Mazzini G. S., Kristem L., Lazaro A., Campos J., Bernardo J., Gonzalez J., Trindade C., Viveiros O., Ribeiro R., Goitein D., Hazzan D., Segev L., Beck T., Reyes H., Monterrubio J., Garcia P., Benois M., Kassir R., Contine A., Elshafei M., Aktas S., Weiner S., Heidsieck T., Level L., Pinango S., Ortega P. M., Moncada R., Valenti V., Vlahovic I., Boras Z., Liagre A., Martini F., Juglard G., Motwani M., Saggu S. S., Momani H. A., Lopez L. A. A., Cortez M. A. C., Zavala R. A., D'Haese RN C., Kempeneers I., Himpens J., Lazzati A., Paolino L., Bathaei S., Bedirli A., Yavuz A., Buyukkasap C., Ozaydin S., Kwiatkowski A., Bartosiak K., Waledziak M., Santonicola A., Angrisani L., Iovino P., Palma R., Iossa A., Boru C. E., De Angelis F., Silecchia G., Hussain A., Balchandra S., Coltell I. B., Perez J. L., Bohra A., Awan A. K., Madhok B., Leeder P. C., Awad S., Al-Khyatt W., Shoma A., Elghadban H., Ghareeb S., Mathews B., Kurian M., Larentzakis A., Vrakopoulou G. Z., Albanopoulos K., Bozdag A., Lale A., Kirkil C., Dincer M., Bashir A., Haddad A., Hijleh L. A., Zilberstein B., de Marchi D. D., Souza W. P., Broden C. M., Gislason H., Shah K., Ambrosi A., Pavone G., Tartaglia N., Kona S. L. K., Kalyan K., Perez C. E. G., Botero M. A. F., Covic A., Timofte D., Maxim M., Faraj D., Tseng L., Liem R., Oren G., Dilektasli E., Yalcin I., AlMukhtar H., Hadad M. A., Mohan R., Arora N., Bedi D., Rives-Lange C., Chevallier J. -M., Poghosyan T., Sebbag H., Zinai L., Khaldi S., Mauchien C., Mazza D., Dinescu G., Rea B., Perez-Galaz F., Zavala L., Besa A., Curell A., Balibrea J. M., Vaz C., Galindo L., Silva N., Caballero J. L. E., Sebastian S. O., Marchesini J. C. D., da Fonseca Pereira R. A., Sobottka W. H., Fiolo F. E., Turchi M., Coelho A. C. J., Zacaron A. L., Barbosa A., Quinino R., Menaldi G., Paleari N., Martinez-Duartez P., de Esparza G. M. A. R., Esteban V. S., Torres A., Garcia-Galocha J. L., Josa M., Pacheco-Garcia J. M., Mayo-Ossorio M. A., Chowbey P., Soni V., de Vasconcelos Cunha H. A., Castilho M. V., Ferreira R. M. A., Barreiro T. A., Charalabopoulos A., Sdralis E., Davakis S., Bomans B., Dapri G., Van Belle K., Takieddine M., Vaneukem P., Karaca E. S. A., Karaca F. C., Sumer A., Peksen C., Savas O. A., Chousleb E., Elmokayed F., Fakhereldin I., Aboshanab H. M., Swelium T., Gudal A., Gamloo L., Ugale A., Ugale S., Boeker C., Reetz C., Hakami I. A., Mall J., Alexandrou A., Baili E., Bodnar Z., Maleckas A., Gudaityte R., Guldogan C. E., Gundogdu E., Ozmen M. M., Thakkar D., Dukkipati N., Shah P. S., Shah S. S., Adil M. T., Jambulingam P., Mamidanna R., Whitelaw D., Jain V., Veetil D. K., Wadhawan R., Torres M., Tinoco T., Leclercq W., Romeijn M., van de Pas K., Alkhazraji A. K., Taha S. A., Ustun M., Yigit T., Inam A., Burhanulhaq M., Pazouki A., Eghbali F., Kermansaravi M., Jazi A. H. D., Mahmoudieh M., Mogharehabed N., Tsiotos G., Stamou K., Rodriguez F. J. B., Navarro M. A. R., Torres O. M., Martinez S. L., Tamez E. R. M., Cornejo G. A. M., Flores J. E. G., Mohammed D. A., Elfawal M. H., Shabbir A., Guowei K., So J. B., Kaplan E. T., Kaplan M., Kaplan T., Pham D. T., Rana G., Kappus M., Gadani R., Kahitan M., Pokharel K., Osborne A., Pournaras D., Hewes J., Napolitano E., Chiappetta S., Bottino V., Dorado E., Schoettler A., Gaertner D., Fedtke K., Aguilar-Espinosa F., Aceves-Lozano S., Balani A., Nagliati C., Pennisi D., Rizzi A., Frattini F., Foschi D., Benuzzi L., Parikh C., Shah H., Pinotti E., Montuori M., Borrelli V., Dargent J., Copaescu C. A., Hutopila I., Smeu B., Witteman B., Hazebroek E., Deden L., Heusschen L., Okkema S., Aufenacker T., den Hengst W., Vening W., van der Burgh Y., Ghazal A., Ibrahim H., Niazi M., Alkhaffaf B., Altarawni M., Cesana G. C., Anselmino M., Uccelli M., Olmi S., Stier C., Akmanlar T., Sonnenberg T., Schieferbein U., Marcolini A., Awruch D., Vicentin M., de Souza Bastos E. L., Gregorio S. A., Ahuja A., Mittal T., Bolckmans R., Baratte C., Wisnewsky J. A., Genser L., Chong L., Taylor L., Ward S., Hi M. W., Heneghan H., Fearon N., Plamper A., Rheinwalt K., Geoghegan J., Ng K. C., Kaseja K., Kotowski M., Samarkandy T. A., Leyva-Alvizo A., Corzo-Culebro L., Wang C., Yang W., Dong Z., Riera M., Jain R., Hamed H., Said M., Zarzar K., Garcia M., Turkcapar A. G., Sen O., Baldini E., Conti L., Wietzycoski C., Lopes E., Pintar T., Salobir J., Aydin C., Atici S. D., Ergin A., Ciyiltepe H., Bozkurt M. A., Kizilkaya M. C., Onalan N. B. D., Zuber M. N. B. A., Wong W. J., Garcia A., Vidal L., Beisani M., Pasquier J., Vilallonga R., Sharma S., Parmar C., Lee L., Sufi P., Sinan H., Saydam M., Singhal, R., Cardoso, V. R., Wiggins, T., Super, J., Ludwig, C., Gkoutos, G. V., Mahawar, K., Pedziwiatr, M., Major, P., Zarzycki, P., Pantelis, A., Lapatsanis, D. P., Stravodimos, G., Matthys, C., Focquet, M., Vleeschouwers, W., Spaventa, A. G., Zerrweck, C., Vitiello, A., Berardi, G., Musella, M., Sanchez-Meza, A., Cantu, F. J., Mora, F., Cantu, M. A., Katakwar, A., Reddy, D. N., Elmaleh, H., Hassan, M., Elghandour, A., Elbanna, M., Osman, A., Khan, A., Layani, L., Kiran, N., Velikorechin, A., Solovyeva, M., Melali, H., Shahabi, S., Agrawal, A., Shrivastava, A., Sharma, A., Narwaria, B., Narwaria, M., Raziel, A., Sakran, N., Susmallian, S., Karagoz, L., Akbaba, M., Piskin, S. Z., Balta, A. Z., Senol, Z., Manno, E., Iovino, M. G., Qassem, M., Arana-Garza, S., Povoas, H. P., Vilas-Boas, M. L., Naumann, D., Li, A., Ammori, B. J., Balamoun, H., Salman, M., Nasta, A. M., Goel, R., Sanchez-Aguilar, H., Herrera, M. F., Abou-mrad, A., Cloix, L., Mazzini, G. S., Kristem, L., Lazaro, A., Campos, J., Bernardo, J., Gonzalez, J., Trindade, C., Viveiros, O., Ribeiro, R., Goitein, D., Hazzan, D., Segev, L., Beck, T., Reyes, H., Monterrubio, J., Garcia, P., Benois, M., Kassir, R., Contine, A., Elshafei, M., Aktas, S., Weiner, S., Heidsieck, T., Level, L., Pinango, S., Ortega, P. M., Moncada, R., Valenti, V., Vlahovic, I., Boras, Z., Liagre, A., Martini, F., Juglard, G., Motwani, M., Saggu, S. S., Momani, H. A., Lopez, L. A. A., Cortez, M. A. C., Zavala, R. A., D'Haese RN, C., Kempeneers, I., Himpens, J., Lazzati, A., Paolino, L., Bathaei, S., Bedirli, A., Yavuz, A., Buyukkasap, C., Ozaydin, S., Kwiatkowski, A., Bartosiak, K., Waledziak, M., Santonicola, A., Angrisani, L., Iovino, P., Palma, R., Iossa, A., Boru, C. E., De Angelis, F., Silecchia, G., Hussain, A., Balchandra, S., Coltell, I. B., Perez, J. L., Bohra, A., Awan, A. K., Madhok, B., Leeder, P. C., Awad, S., Al-Khyatt, W., Shoma, A., Elghadban, H., Ghareeb, S., Mathews, B., Kurian, M., Larentzakis, A., Vrakopoulou, G. Z., Albanopoulos, K., Bozdag, A., Lale, A., Kirkil, C., Dincer, M., Bashir, A., Haddad, A., Hijleh, L. A., Zilberstein, B., de Marchi, D. D., Souza, W. P., Broden, C. M., Gislason, H., Shah, K., Ambrosi, A., Pavone, G., Tartaglia, N., Kona, S. L. K., Kalyan, K., Perez, C. E. G., Botero, M. A. F., Covic, A., Timofte, D., Maxim, M., Faraj, D., Tseng, L., Liem, R., Oren, G., Dilektasli, E., Yalcin, I., Almukhtar, H., Hadad, M. A., Mohan, R., Arora, N., Bedi, D., Rives-Lange, C., Chevallier, J. -M., Poghosyan, T., Sebbag, H., Zinai, L., Khaldi, S., Mauchien, C., Mazza, D., Dinescu, G., Rea, B., Perez-Galaz, F., Zavala, L., Besa, A., Curell, A., Balibrea, J. M., Vaz, C., Galindo, L., Silva, N., Caballero, J. L. E., Sebastian, S. O., Marchesini, J. C. D., da Fonseca Pereira, R. A., Sobottka, W. H., Fiolo, F. E., Turchi, M., Coelho, A. C. J., Zacaron, A. L., Barbosa, A., Quinino, R., Menaldi, G., Paleari, N., Martinez-Duartez, P., de Esparza, G. M. A. R., Esteban, V. S., Torres, A., Garcia-Galocha, J. L., Josa, M., Pacheco-Garcia, J. M., Mayo-Ossorio, M. A., Chowbey, P., Soni, V., de Vasconcelos Cunha, H. A., Castilho, M. V., Ferreira, R. M. A., Barreiro, T. A., Charalabopoulos, A., Sdralis, E., Davakis, S., Bomans, B., Dapri, G., Van Belle, K., Takieddine, M., Vaneukem, P., Karaca, E. S. A., Karaca, F. C., Sumer, A., Peksen, C., Savas, O. A., Chousleb, E., Elmokayed, F., Fakhereldin, I., Aboshanab, H. M., Swelium, T., Gudal, A., Gamloo, L., Ugale, A., Ugale, S., Boeker, C., Reetz, C., Hakami, I. A., Mall, J., Alexandrou, A., Baili, E., Bodnar, Z., Maleckas, A., Gudaityte, R., Guldogan, C. E., Gundogdu, E., Ozmen, M. M., Thakkar, D., Dukkipati, N., Shah, P. S., Shah, S. S., Adil, M. T., Jambulingam, P., Mamidanna, R., Whitelaw, D., Jain, V., Veetil, D. K., Wadhawan, R., Torres, M., Tinoco, T., Leclercq, W., Romeijn, M., van de Pas, K., Alkhazraji, A. K., Taha, S. A., Ustun, M., Yigit, T., Inam, A., Burhanulhaq, M., Pazouki, A., Eghbali, F., Kermansaravi, M., Jazi, A. H. D., Mahmoudieh, M., Mogharehabed, N., Tsiotos, G., Stamou, K., Rodriguez, F. J. B., Navarro, M. A. R., Torres, O. M., Martinez, S. L., Tamez, E. R. M., Cornejo, G. A. M., Flores, J. E. G., Mohammed, D. A., Elfawal, M. H., Shabbir, A., Guowei, K., So, J. B., Kaplan, E. T., Kaplan, M., Kaplan, T., Pham, D. T., Rana, G., Kappus, M., Gadani, R., Kahitan, M., Pokharel, K., Osborne, A., Pournaras, D., Hewes, J., Napolitano, E., Chiappetta, S., Bottino, V., Dorado, E., Schoettler, A., Gaertner, D., Fedtke, K., Aguilar-Espinosa, F., Aceves-Lozano, S., Balani, A., Nagliati, C., Pennisi, D., Rizzi, A., Frattini, F., Foschi, D., Benuzzi, L., Parikh, C., Shah, H., Pinotti, E., Montuori, M., Borrelli, V., Dargent, J., Copaescu, C. A., Hutopila, I., Smeu, B., Witteman, B., Hazebroek, E., Deden, L., Heusschen, L., Okkema, S., Aufenacker, T., den Hengst, W., Vening, W., van der Burgh, Y., Ghazal, A., Ibrahim, H., Niazi, M., Alkhaffaf, B., Altarawni, M., Cesana, G. C., Anselmino, M., Uccelli, M., Olmi, S., Stier, C., Akmanlar, T., Sonnenberg, T., Schieferbein, U., Marcolini, A., Awruch, D., Vicentin, M., de Souza Bastos, E. L., Gregorio, S. A., Ahuja, A., Mittal, T., Bolckmans, R., Baratte, C., Wisnewsky, J. A., Genser, L., Chong, L., Taylor, L., Ward, S., Hi, M. W., Heneghan, H., Fearon, N., Plamper, A., Rheinwalt, K., Geoghegan, J., Ng, K. C., Kaseja, K., Kotowski, M., Samarkandy, T. A., Leyva-Alvizo, A., Corzo-Culebro, L., Wang, C., Yang, W., Dong, Z., Riera, M., Jain, R., Hamed, H., Said, M., Zarzar, K., Garcia, M., Turkcapar, A. G., Sen, O., Baldini, E., Conti, L., Wietzycoski, C., Lopes, E., Pintar, T., Salobir, J., Aydin, C., Atici, S. D., Ergin, A., Ciyiltepe, H., Bozkurt, M. A., Kizilkaya, M. C., Onalan, N. B. D., Zuber, M. N. B. A., Wong, W. J., Garcia, A., Vidal, L., Beisani, M., Pasquier, J., Vilallonga, R., Sharma, S., Parmar, C., Lee, L., Sufi, P., Sinan, H., Saydam, M., İstinye Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Sumer, Aziz, Peksen, Caghan, and Savas, Osman Anil

Subjects
Nutrition and Dietetics, Endocrinology, Diabetes and Metabolism, Gastric Bypass, Medicine (miscellaneous), nutritional and metabolic diseases, COVID-19, Gastrectomy, Humans, Morbidity, Propensity Score, Retrospective Studies, Treatment Outcome, Diabetes Mellitus, Type 2, Obesity, Morbid, Article, Diabetes Mellitus, Obesity, Morbid, Type 2
Abstract

Background There is a paucity of data comparing 30-day morbidity and mortality of sleeve gastrectomy (SG), Roux-en-Y gastric bypass (RYGB), and one anastomosis gastric bypass (OAGB). This study aimed to compare the 30-day safety of SG, RYGB, and OAGB in propensity score-matched cohorts. Materials and methods This analysis utilised data collected from the GENEVA study which was a multicentre observational cohort study of bariatric and metabolic surgery (BMS) in 185 centres across 42 countries between 01/05/2022 and 31/10/2020 during the Coronavirus Disease-2019 (COVID-19) pandemic. 30-day complications were categorised according to the Clavien–Dindo classification. Patients receiving SG, RYGB, or OAGB were propensity-matched according to baseline characteristics and 30-day complications were compared between groups. Results In total, 6770 patients (SG 3983; OAGB 702; RYGB 2085) were included in this analysis. Prior to matching, RYGB was associated with highest 30-day complication rate (SG 5.8%; OAGB 7.5%; RYGB 8.0% (p = 0.006)). On multivariate regression modelling, Insulin-dependent type 2 diabetes mellitus and hypercholesterolaemia were associated with increased 30-day complications. Being a non-smoker was associated with reduced complication rates. When compared to SG as a reference category, RYGB, but not OAGB, was associated with an increased rate of 30-day complications. A total of 702 pairs of SG and OAGB were propensity score-matched. The complication rate in the SG group was 7.3% (n = 51) as compared to 7.5% (n = 53) in the OAGB group (p = 0.68). Similarly, 2085 pairs of SG and RYGB were propensity score-matched. The complication rate in the SG group was 6.1% (n = 127) as compared to 7.9% (n = 166) in the RYGB group (p = 0.09). And, 702 pairs of OAGB and RYGB were matched. The complication rate in both groups was the same at 7.5 % (n = 53; p = 0.07). Conclusions This global study found no significant difference in the 30-day morbidity and mortality of SG, RYGB, and OAGB in propensity score-matched cohorts.

Published
2021

7. Laparoscopic right hemicolectomy: the SICE (Società Italiana di Chirurgia Endoscopica e Nuove Tecnologie) network prospective trial on 1225 cases comparing intra corporeal versus extra corporeal ileo-colic side-to-side anastomosis

Author

Anania G., Agresta F., Artioli E., Rubino S., Resta G., Vettoretto N., Petz W. L., Bergamini C., Arezzo A., Valpiani G., Morotti C., Silecchia G., Adamo V., Agrusa A., Alemanno G., Allaix M. E., Alo A., Altamura A., Ambrosi A., Antoniutti M., Apa D., Arcuri G., Baiocchi G. L., Balani A., Baldazzi G., Basti M., Benvenuto C., Berti S., Boni L., Borghi F., Botteri E., Brachet Contul R., Brescia A., Budassi A., Cafagna L., Calgaro M., Calo P. G., Campagnacci R., Canova G., Canu G. L., Caracino V., Carcoforo P., Carlini M., Casali L., Cassetti D., Cassinotti E., Catarci M., Cesari M., Checcacci P., Ciano P., Clementi M., Cocorullo G., Colombo F., Concone G., Contine A., Coppola M., Coratti A., Corcione F., Corleone P., Covotta L., Cuccurullo D., Cumbo P., D'ambrosio G., De Angelis F., De Luca M., De Manzini N., De Nisco C., De Palma G. D., De Paolis P., Degiuli M., Delogu D., Delrio P., Deserra A., Donini A., Elmore U., Ercolani G., Erdas E., Fabris L., Ferrari G., Feo G., Fidanza F., Foschi D., Galleano R., Garulli G., Gatti F., Gattolin A., Gelati S., Gelmini R., Ghazouani O., Gioffre A., Gobbi S., Grammatico V., Guariniello A., Giannessi S., Guerrieri M., Guerriero L., Gullotta G., Impellizzeri H., Izzo M., Jovine E., Lezoche G., Lirusso C., Lombardi R., Longoni M., Lucchi A., Luzzi A. P., Marini P., Marrosu A. G., Martino A., Mazza R., Mazzoccato S., Medas F., Meloni A., Milone M., Minciotti E., Monari F., Moretto G., Muttillo I. A., Navarra G., Neri S., Oldani A., Olmi S., Opocher E., Osenda E., Ottonello R., Panebianco V., Pavanello M., Pecchini F., Pellegrino L., Pennisi D., Perrotta N., Pertile D., Petri R., Picchetto A., Piccoli M., Pirrera B., Pisani Ceretti A., Pisano M., Podda M., Portolani N., Presenti L., Puzziello A., Razzi S., Rega D., Restini E., Ricci G., Rigamonti M., Rivolta U., Robustelli V., Romairone E., Rosati R., Rosso E., Roviello F., Sala S., Santarelli M., Sarro G., Sartori A., Scabini S., Scognamillo F., Sechi R., Solaini L., Soliani G., Soliani P., Soligo E., Sorrentino M., Spinoglio G., Stratta E., Taddei A., Talamo G., Targa S., Tartaglia N., Testa S., Ubiali P., Valeri A., Vasta F., Verzelli A., Vicentini R., Viola G., Violi V., Zago M., Zampino L., Anania, G., Agresta, F., Artioli, E., Rubino, S., Resta, G., Vettoretto, N., Petz, W. L., Bergamini, C., Arezzo, A., Valpiani, G., Morotti, C., Silecchia, G., Adamo, V., Agrusa, A., Alemanno, G., Allaix, M. E., Alo, A., Altamura, A., Ambrosi, A., Antoniutti, M., Apa, D., Arcuri, G., Baiocchi, G. L., Balani, A., Baldazzi, G., Basti, M., Benvenuto, C., Berti, S., Boni, L., Borghi, F., Botteri, E., Brachet Contul, R., Brescia, A., Budassi, A., Cafagna, L., Calgaro, M., Calo, P. G., Campagnacci, R., Canova, G., Canu, G. L., Caracino, V., Carcoforo, P., Carlini, M., Casali, L., Cassetti, D., Cassinotti, E., Catarci, M., Cesari, M., Checcacci, P., Ciano, P., Clementi, M., Cocorullo, G., Colombo, F., Concone, G., Contine, A., Coppola, M., Coratti, A., Corcione, F., Corleone, P., Covotta, L., Cuccurullo, D., Cumbo, P., D'Ambrosio, G., De Angelis, F., De Luca, M., De Manzini, N., De Nisco, C., De Palma, G. D., De Paolis, P., Degiuli, M., Delogu, D., Delrio, P., Deserra, A., Donini, A., Elmore, U., Ercolani, G., Erdas, E., Fabris, L., Ferrari, G., Feo, G., Fidanza, F., Foschi, D., Galleano, R., Garulli, G., Gatti, F., Gattolin, A., Gelati, S., Gelmini, R., Ghazouani, O., Gioffre, A., Gobbi, S., Grammatico, V., Guariniello, A., Giannessi, S., Guerrieri, M., Guerriero, L., Gullotta, G., Impellizzeri, H., Izzo, M., Jovine, E., Lezoche, G., Lirusso, C., Lombardi, R., Longoni, M., Lucchi, A., Luzzi, A. P., Marini, P., Marrosu, A. G., Martino, A., Mazza, R., Mazzoccato, S., Medas, F., Meloni, A., Milone, M., Minciotti, E., Monari, F., Moretto, G., Muttillo, I. A., Navarra, G., Neri, S., Oldani, A., Olmi, S., Opocher, E., Osenda, E., Ottonello, R., Panebianco, V., Pavanello, M., Pecchini, F., Pellegrino, L., Pennisi, D., Perrotta, N., Pertile, D., Petri, R., Picchetto, A., Piccoli, M., Pirrera, B., Pisani Ceretti, A., Pisano, M., Podda, M., Portolani, N., Presenti, L., Puzziello, A., Razzi, S., Rega, D., Restini, E., Ricci, G., Rigamonti, M., Rivolta, U., Robustelli, V., Romairone, E., Rosati, R., Rosso, E., Roviello, F., Sala, S., Santarelli, M., Sarro, G., Sartori, A., Scabini, S., Scognamillo, F., Sechi, R., Solaini, L., Soliani, G., Soliani, P., Soligo, E., Sorrentino, M., Spinoglio, G., Stratta, E., Taddei, A., Talamo, G., Targa, S., Tartaglia, N., Testa, S., Ubiali, P., Valeri, A., Vasta, F., Verzelli, A., Vicentini, R., Viola, G., Violi, V., Zago, M., Zampino, L., Anania G., Agresta F., Artioli E., Rubino S., Resta G., Vettoretto N., Petz W.L., Bergamini C., Arezzo A., Valpiani G., Morotti C., Silecchia G, and Adamo V, Agrusa A, Alemanno G, Allaix ME, Alò A, Altamura A, Ambrosi A, Antoniutti M, Apa D, Arcuri G, Baiocchi GL, Balani A, Baldazzi G, Basti M, Benvenuto C, Berti S, Boni L, Borghi F, Botteri E, Brachet Contul R, Brescia A, Budassi A, Cafagna L, Calgaro M, Calò PG, Campagnacci R, Canova G, Canu GL, Caracino V, Carcoforo P, Carlini M, Casali L, Cassetti D, Cassinotti E, Catarci M, Cesari M, Checcacci P, Ciano P, Clementi M, Cocorullo G, Colombo F, Concone G, Contine A, Coppola M, Coratti A, Corcione F, Corleone P, Covotta L, Cuccurullo D, Cumbo P, D'Ambrosio G, De Angelis F, De Luca M, De Manzini N, De Nisco C, De Palma GD, De Paolis P, Degiuli M, Delogu D, Delrio P, Deserra A, Donini A, Elmore U, Ercolani G, Erdas E, Fabris L, Ferrari G, Feo C, Fidanza F, Foschi D, Galleano R, Garulli G, Gatti F, Gattolin A, Gelati S, Gelmini R, Ghazouani O, Gioffrè A, Gobbi S, Grammatico V, Guariniello A, Giannessi S, Guerrieri M, Guerriero L, Guerriero G, Impellizzeri H, Izzo M, Jovine E, Lezoche G, Lirusso C, Lombardi R, Longoni M, Lucchi A, Luzzi AP, Marini P, Marrosu AG, Martino A, Mazza R, Mazzoccato S, Medas F, Meloni A, Milone M, Minciotti E, Monari F, Moretto G, Muttillo IA, Navarra G, Neri S, Oldani A, Olmi S, Opocher E, Osenda E, Ottonello R, Panebianco V, Pavanello M, Pecchini F, Pellegrino L, Pennisi D, Perrotta N, Pertile D, Petri R, Picchetto A, Piccoli M, Pirrera B, Pisani Ceretti A, Pisano M, Podda M, Portolani N, Presenti L, Puzziello A, Razzi S, Rega D, Restini E, Ricci G, Rigamonti M, Rivolta U, Robustelli V, Romairone E, Rosati R, Rosso E, Roviello F, Sala S, Santarelli M, Sarro G, Sartori A, Scabini S, Scognamillo F, Sechi R, Solaini L, Soliani G, Soliani P, Soligo E, Sorrentino M, Spinoglio G, Stratta E, Taddei A, Talamo G, Targa S, Tartaglia N, Testa S, Ubiali P, Valeri A, Vasta F, Verzelli A, Vicentini R, Viola G, Violi V, Zago M, Zampino L.

Subjects
Male, medicine.medical_specialty, Anastomosis, Colon, Intracorporeal anastomosis, Outcomes, Laparoscopic colectomy, Article, Intracorporeal anastomosi, Ileo-colic anastomosis, Laparoscopy, Postoperative complications, Right hemicolectomy, Aged, Anastomosis, Surgical, Colectomy, Colonic Neoplasms, Female, Humans, Prospective Studies, Treatment Outcome, Economica, Surgical, medicine, LS7_1, LS7_4, Right hemicolectomy, Ileo-colic anastomosis, Laparoscopy, Postoperative complications, Intracorporeal anastomosis, Outcomes, Outcome, LS7_9, medicine.diagnostic_test, business.industry, General surgery, Right hemicolectomy · Ileo-colic anastomosis · Laparoscopy · Postoperative complications · Intracorporeal anastomosis · Outcomes, Correction, Postoperative complication, Ileo-colic anastomosi, Prospective trial, Surgery, Side to side anastomosis, business, Laparoscopic right hemicolectomy
Abstract

Background While laparoscopic approach for right hemicolectomy (LRH) is considered appropriate for the surgical treatment of both malignant and benign diseases of right colon, there is still debate about how to perform the ileo-colic anastomosis. The ColonDxItalianGroup (CoDIG) was designed as a cohort, observational, prospective, multi-center national study with the aims of evaluating the surgeons’ attitude regarding the intracorporeal (ICA) or extra-corporeal (ECA) anastomotic technique and the related surgical outcomes. Methods One hundred and twenty-five Surgical Units experienced in colorectal and advanced laparoscopic surgery were invited and 85 of them joined the study. Each center was asked not to change its surgical habits. Data about demographic characteristics, surgical technique and postoperative outcomes were collected through the official SICE website database. One thousand two hundred and twenty-five patients were enrolled between March 2018 and September 2018. Results ICA was performed in 70.4% of cases, ECA in 29.6%. Isoperistaltic anastomosis was completed in 85.6%, stapled in 87.9%. Hand-sewn enterotomy closure was adopted in 86%. Postoperative complications were reported in 35.4% for ICA and 50.7% for ECA; no significant difference was found according to patients’ characteristics and technologies used. Median hospital stay was significantly shorter for ICA (7.3 vs. 9 POD). Postoperative pain in patients not prescribed opioids was significantly lower in ICA group. Conclusions In our survey, a side-to-side isoperistaltic stapled ICA with hand-sewn enterotomy closure is the most frequently adopted technique to perform ileo-colic anastomosis after any indications for elective LRH. According to literature, our study confirmed better short-term outcomes for ICA, with reduction of hospital stay and postoperative pain. Trial registration Clinical trial (Identifier: NCT03934151).

Published
2020

10. 30-Day morbidity and mortality of bariatric metabolic surgery in adolescence during the COVID-19 pandemic – The GENEVA study

Author

Singhal R., Wiggins T., Super J., Alqahtani A., Nadler E. P., Ludwig C., Tahrani A., Mahawar K., Pedziwiatr M., Major P., Zarzycki P., Pantelis A., Lapatsanis D. P., Stravodimos G., Matthys C., Focquet M., Vleeschouwers W., Spaventa A. G., Zerrweck C., Vitiello A., Berardi G., Musella M., Sanchez-Meza A., Cantu F. J., Mora F., Cantu M. A., Katakwar A., Reddy D. N., Elmaleh H., Hassan M., Elghandour A., Elbanna M., Osman A., Khan A., Layani L., Kiran N., Velikorechin A., Solovyeva M., Melali H., Shahabi S., Agrawal A., Shrivastava A., Sharma A., Narwaria B., Narwaria M., Raziel A., Sakran N., Susmallian S., Karagoz L., Akbaba M., Piskin S. Z., Ziya A., Senol Z., Manno E., Iovino M. G., Qassem M., Arana-Garza S., Povoas H. P., Vilas-Boas M. L., Naumann D., Li A., Ammori B. J., Balamoun H., Salman M., Nasta A. M., Goel R., Sanchez-Aguilar H., Herrera M. F., Abou-Mrad A., Cloix L., Mazzini G. S., Kristem L., Lazaro A., Campos J., Bernardo J., Gonzalez J., Trindade C., Viveiros O., Ribeiro R., Goitein D., Hazzan D., Segev L., Beck T., Reyes H., Monterrubio J., Garcia P., Benois M., Kassir R., Contine A., Elshafei M., Aktas S., Weiner S., Heidsieck T., Level L., Pinango S., Ortega P. M., Moncada R., Valenti V., Vlahovic I., Boras Z., Liagre A., Martini F., Juglard G., Motwani M., Saggu S. S., Al Momani H., Lopez L. A. A., Cortez M. A. C., Zavala R. A., D'Haese C., Kempeneers I., Himpens J., Lazzati A., Paolino L., Bathaei S., Bedirli A., Yavuz A., Buyukkasap C., Ozaydin S., Kwiatkowski A., Bartosiak K., Waledziak M., Santonicola A., Angrisani L., Iovino P., Palma R., Iossa A., Boru C. E., De Angelis F., Silecchia G., Hussain A., Balchandra S., Coltell I. B., Perez J. L., Bohra A., Awan A. K., Madhok B., Leeder P. C., Awad S., Al-Khyatt W., Shoma A., Elghadban H., Ghareeb S., Mathews B., Kurian M., Larentzakis A., Vrakopoulou G. Z., Albanopoulos K., Bozdag A., Lale A., Kirkil C., Dincer M., Bashir A., Haddad A., Hijleh L. A., Zilberstein B., de Marchi D. D., Souza W. P., Broden C. M., Gislason H., Shah K., Ambrosi A., Pavone G., Tartaglia N., Kona S. L. K., Kalyan K., Perez C. E. G., Botero M. A. F., Covic A., Timofte D., Maxim M., Faraj D., Tseng L., Liem R., Oren G., Dilektasli E., Yalcin I., AlMukhtar H., Al Hadad M., Mohan R., Arora N., Bedi D., Rives-Lange C., Chevallier J. -M., Poghosyan T., Sebbag H., Zinai L., Khaldi S., Mauchien C., Mazza D., Dinescu G., Rea B., Perez-Galaz F., Zavala L., Besa A., Curell A., Balibrea J. M., Vaz C., Galindo L., Silva N., Caballero J. L. E., Sebastian S. O., Marchesini J. C. D., da Fonseca Pereira R. A., Sobottka W. H., Fiolo F. E., Turchi M., Coelho A. C. J., Zacaron A. L., Barbosa A., Quinino R., Menaldi G., Paleari N., Martinez-Duartez P., Aragon Ramirez de Esparza D. G. M., Esteban V. S., Torres A., Garcia-Galocha J. L., Josa M. I., Pacheco-Garcia J. M., Mayo-Ossorio M. A., Chowbey P., Soni V., de Vasconcelos Cunha H. A., Castilho M. V., Ferreira R. M. A., Barreiro T. A., Charalabopoulos A., Sdralis E., Davakis S., Bomans B., Dapri G., Van Belle K., MazenTakieddine, Vaneukem P., Karaca E. S. A., Karaca F. C., Sumer A., Peksen C., Savas O. A., Chousleb E., Elmokayed F., Fakhereldin I., Aboshanab H. M., Swelium T., Gudal A., Gamloo L., Ugale A., Ugale S., Boeker C., Reetz C., Hakami I. A., Mall J., Alexandrou A., Baili E., Bodnar Z., Maleckas A., Gudaityte R., Guldogan C. E., Gundogdu E., Ozmen M. M., Thakkar D., Dukkipati N., Shah P. S., Shah S. S., Adil M. T., Jambulingam P., Mamidanna R., Whitelaw D., Jain V., Veetil D. K., Wadhawan R., Torres M., Tinoco T., Leclercq W., Romeijn M., van de Pas K., Alkhazraji A. K., Taha S. A., Ustun M., Yigit T., Inam A., Burhanulhaq M., Pazouki A., Eghbali F., Kermansaravi M., Jazi A. H. D., Mahmoudieh M., Mogharehabed N., Tsiotos G., Stamou K., Barrera Rodriguez F. J., Rojas Navarro M. A., Torres O. M. O., Martinez S. L., Tamez E. R. M., Millan Cornejo G. A., Flores J. E. G., Mohammed D. A., Elfawal M. H., Shabbir A., Guowei K., So J. B. Y., Kaplan E. T., Kaplan M., Kaplan T., Pham D. T., Rana G., Kappus M., Gadani R., Kahitan M., Pokharel K., Osborne A., Pournaras D., Hewes J., Napolitano E., Chiappetta S., Bottino V., Dorado E., Schoettler A., Gaertner D., Fedtke K., Aguilar-Espinosa F., Aceves-Lozano S., Balani A., Nagliati C., Pennisi D., Rizzi A., Frattini F., Foschi D., Benuzzi L., Parikh C. H. I. R. A. G., Shah H. A. R. S. H. I. L., Pinotti E., Montuori M., Borrelli V., Dargent J., Copaescu C. A., Hutopila I., Smeu B., Witteman B., Hazebroek E., Deden L., Heusschen L., Okkema S., Aufenacker T., den Hengst W., Vening W., van der Burgh Y., Ghazal A., Ibrahim H., Niazi M., Alkhaffaf B., Altarawni M., Cesana G. C., Anselmino M., Uccelli M., Olmi S., Stier C., Akmanlar T., Sonnenberg T., Schieferbein U., Marcolini A., Awruch D., Vicentin M., de Souza Bastos E. L., Gregorio S. A., Ahuja A., Mittal T., Bolckmans R., Baratte C., Wisnewsky J. A., Genser L., Chong L., Taylor L., Ward S., Hi M. W., Heneghan H., Fearon N., Plamper A., Rheinwalt K., Geoghegan J., Ng K. C., Kaseja K., Kotowski M., Samarkandy T. A., Leyva-Alvizo A., Corzo-Culebro L., Wang C., Yang W., Dong Z., Riera M., Jain R., Hamed H., Said M., Zarzar K., Garcia M., Turkcapar A. G., Sen O., Baldini E., Conti L., Wietzycoski C., Lopes E., Pintar T., Salobir J., Aydin C., Atici S. D., Ergin A., Ciyiltepe H., Bozkurt M. A., Kizilkaya M. C., Onalan N. B. D., Zuber M. N. B. A., Wong W. J., Garcia A., Vidal L., Beisani M., Pasquier J., Vilallonga R., Sharma S., Parmar C., Lee L., Sufi P., Sinan H., Saydam M., Singhal, R., Wiggins, T., Super, J., Alqahtani, A., Nadler, E. P., Ludwig, C., Tahrani, A., Mahawar, K., Pedziwiatr, M., Major, P., Zarzycki, P., Pantelis, A., Lapatsanis, D. P., Stravodimos, G., Matthys, C., Focquet, M., Vleeschouwers, W., Spaventa, A. G., Zerrweck, C., Vitiello, A., Berardi, G., Musella, M., Sanchez-Meza, A., Cantu, F. J., Mora, F., Cantu, M. A., Katakwar, A., Reddy, D. N., Elmaleh, H., Hassan, M., Elghandour, A., Elbanna, M., Osman, A., Khan, A., Layani, L., Kiran, N., Velikorechin, A., Solovyeva, M., Melali, H., Shahabi, S., Agrawal, A., Shrivastava, A., Sharma, A., Narwaria, B., Narwaria, M., Raziel, A., Sakran, N., Susmallian, S., Karagoz, L., Akbaba, M., Piskin, S. Z., Ziya, A., Senol, Z., Manno, E., Iovino, M. G., Qassem, M., Arana-Garza, S., Povoas, H. P., Vilas-Boas, M. L., Naumann, D., Li, A., Ammori, B. J., Balamoun, H., Salman, M., Nasta, A. M., Goel, R., Sanchez-Aguilar, H., Herrera, M. F., Abou-Mrad, A., Cloix, L., Mazzini, G. S., Kristem, L., Lazaro, A., Campos, J., Bernardo, J., Gonzalez, J., Trindade, C., Viveiros, O., Ribeiro, R., Goitein, D., Hazzan, D., Segev, L., Beck, T., Reyes, H., Monterrubio, J., Garcia, P., Benois, M., Kassir, R., Contine, A., Elshafei, M., Aktas, S., Weiner, S., Heidsieck, T., Level, L., Pinango, S., Ortega, P. M., Moncada, R., Valenti, V., Vlahovic, I., Boras, Z., Liagre, A., Martini, F., Juglard, G., Motwani, M., Saggu, S. S., Al Momani, H., Lopez, L. A. A., Cortez, M. A. C., Zavala, R. A., D'Haese, C., Kempeneers, I., Himpens, J., Lazzati, A., Paolino, L., Bathaei, S., Bedirli, A., Yavuz, A., Buyukkasap, C., Ozaydin, S., Kwiatkowski, A., Bartosiak, K., Waledziak, M., Santonicola, A., Angrisani, L., Iovino, P., Palma, R., Iossa, A., Boru, C. E., De Angelis, F., Silecchia, G., Hussain, A., Balchandra, S., Coltell, I. B., Perez, J. L., Bohra, A., Awan, A. K., Madhok, B., Leeder, P. C., Awad, S., Al-Khyatt, W., Shoma, A., Elghadban, H., Ghareeb, S., Mathews, B., Kurian, M., Larentzakis, A., Vrakopoulou, G. Z., Albanopoulos, K., Bozdag, A., Lale, A., Kirkil, C., Dincer, M., Bashir, A., Haddad, A., Hijleh, L. A., Zilberstein, B., de Marchi, D. D., Souza, W. P., Broden, C. M., Gislason, H., Shah, K., Ambrosi, A., Pavone, G., Tartaglia, N., Kona, S. L. K., Kalyan, K., Perez, C. E. G., Botero, M. A. F., Covic, A., Timofte, D., Maxim, M., Faraj, D., Tseng, L., Liem, R., Oren, G., Dilektasli, E., Yalcin, I., Almukhtar, H., Al Hadad, M., Mohan, R., Arora, N., Bedi, D., Rives-Lange, C., Chevallier, J. -M., Poghosyan, T., Sebbag, H., Zinai, L., Khaldi, S., Mauchien, C., Mazza, D., Dinescu, G., Rea, B., Perez-Galaz, F., Zavala, L., Besa, A., Curell, A., Balibrea, J. M., Vaz, C., Galindo, L., Silva, N., Caballero, J. L. E., Sebastian, S. O., Marchesini, J. C. D., da Fonseca Pereira, R. A., Sobottka, W. H., Fiolo, F. E., Turchi, M., Coelho, A. C. J., Zacaron, A. L., Barbosa, A., Quinino, R., Menaldi, G., Paleari, N., Martinez-Duartez, P., Aragon Ramirez de Esparza, D. G. M., Esteban, V. S., Torres, A., Garcia-Galocha, J. L., Josa, M. I., Pacheco-Garcia, J. M., Mayo-Ossorio, M. A., Chowbey, P., Soni, V., de Vasconcelos Cunha, H. A., Castilho, M. V., Ferreira, R. M. A., Barreiro, T. A., Charalabopoulos, A., Sdralis, E., Davakis, S., Bomans, B., Dapri, G., Van Belle, K., Mazentakieddine, Vaneukem, P., Karaca, E. S. A., Karaca, F. C., Sumer, A., Peksen, C., Savas, O. A., Chousleb, E., Elmokayed, F., Fakhereldin, I., Aboshanab, H. M., Swelium, T., Gudal, A., Gamloo, L., Ugale, A., Ugale, S., Boeker, C., Reetz, C., Hakami, I. A., Mall, J., Alexandrou, A., Baili, E., Bodnar, Z., Maleckas, A., Gudaityte, R., Guldogan, C. E., Gundogdu, E., Ozmen, M. M., Thakkar, D., Dukkipati, N., Shah, P. S., Shah, S. S., Adil, M. T., Jambulingam, P., Mamidanna, R., Whitelaw, D., Jain, V., Veetil, D. K., Wadhawan, R., Torres, M., Tinoco, T., Leclercq, W., Romeijn, M., van de Pas, K., Alkhazraji, A. K., Taha, S. A., Ustun, M., Yigit, T., Inam, A., Burhanulhaq, M., Pazouki, A., Eghbali, F., Kermansaravi, M., Jazi, A. H. D., Mahmoudieh, M., Mogharehabed, N., Tsiotos, G., Stamou, K., Barrera Rodriguez, F. J., Rojas Navarro, M. A., Torres, O. M. O., Martinez, S. L., Tamez, E. R. M., Millan Cornejo, G. A., Flores, J. E. G., Mohammed, D. A., Elfawal, M. H., Shabbir, A., Guowei, K., So, J. B. Y., Kaplan, E. T., Kaplan, M., Kaplan, T., Pham, D. T., Rana, G., Kappus, M., Gadani, R., Kahitan, M., Pokharel, K., Osborne, A., Pournaras, D., Hewes, J., Napolitano, E., Chiappetta, S., Bottino, V., Dorado, E., Schoettler, A., Gaertner, D., Fedtke, K., Aguilar-Espinosa, F., Aceves-Lozano, S., Balani, A., Nagliati, C., Pennisi, D., Rizzi, A., Frattini, F., Foschi, D., Benuzzi, L., Parikh, C. H. I. R. A. G., Shah, H. A. R. S. H. I. L., Pinotti, E., Montuori, M., Borrelli, V., Dargent, J., Copaescu, C. A., Hutopila, I., Smeu, B., Witteman, B., Hazebroek, E., Deden, L., Heusschen, L., Okkema, S., Aufenacker, T., den Hengst, W., Vening, W., van der Burgh, Y., Ghazal, A., Ibrahim, H., Niazi, M., Alkhaffaf, B., Altarawni, M., Cesana, G. C., Anselmino, M., Uccelli, M., Olmi, S., Stier, C., Akmanlar, T., Sonnenberg, T., Schieferbein, U., Marcolini, A., Awruch, D., Vicentin, M., de Souza Bastos, E. L., Gregorio, S. A., Ahuja, A., Mittal, T., Bolckmans, R., Baratte, C., Wisnewsky, J. A., Genser, L., Chong, L., Taylor, L., Ward, S., Hi, M. W., Heneghan, H., Fearon, N., Plamper, A., Rheinwalt, K., Geoghegan, J., Ng, K. C., Kaseja, K., Kotowski, M., Samarkandy, T. A., Leyva-Alvizo, A., Corzo-Culebro, L., Wang, C., Yang, W., Dong, Z., Riera, M., Jain, R., Hamed, H., Said, M., Zarzar, K., Garcia, M., Turkcapar, A. G., Sen, O., Baldini, E., Conti, L., Wietzycoski, C., Lopes, E., Pintar, T., Salobir, J., Aydin, C., Atici, S. D., Ergin, A., Ciyiltepe, H., Bozkurt, M. A., Kizilkaya, M. C., Onalan, N. B. D., Zuber, M. N. B. A., Wong, W. J., Garcia, A., Vidal, L., Beisani, M., Pasquier, J., Vilallonga, R., Sharma, S., Parmar, C., Lee, L., Sufi, P., Sinan, H., and Saydam, M.

Subjects
Male, Pediatrics, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), Adolescent, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), bariatric surgery, Context (language use), Pandemic, Medicine, Humans, Pandemics, COVID-19, pandemic, SARS-CoV-2, Nutrition and Dietetics, Manchester Cancer Research Centre, business.industry, Health Policy, ResearchInstitutes_Networks_Beacons/mcrc, Public Health, Environmental and Occupational Health, medicine.disease, Obesity, Obesity, Morbid, Treatment Outcome, Pediatrics, Perinatology and Child Health, Cohort, Female, Morbidity, business, Body mass index, Cohort study, Human
Abstract

Background: Metabolic and bariatric surgery (MBS) is an effective treatment for adolescents with severe obesity. Objectives: This study examined the safety of MBS in adolescents during the coronavirus disease 2019 (COVID-19) pandemic. Methods: This was a global, multicentre and observational cohort study of MBS performed between May 01, 2020, and October 10,2020, in 68 centres from 24 countries. Data collection included in-hospital and 30-day COVID-19 and surgery-specific morbidity/mortality. Results: One hundred and seventy adolescent patients (mean age: 17.75 ± 1.30 years), mostly females (n=122, 71.8%), underwent MBS during the study period. The mean pre-operative weight and body mass index were 122.16 ± 15.92 kg and 43.7± 7.11 kg/m2, respectively. Although majority of patients had pre-operative testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (n=146; 85.9%), only 42.4% (n=72) of the patients were asked to self-isolate pre-operatively. Two patients developed symptomatic SARS-CoV-2 infection post-operatively (1.2%). The overall complication rate was 5.3% (n=9). There was no mortality in this cohort. Conclusions: MBS in adolescents with obesity is safe during the COVID-19 pandemic when performed within the context of local precautionary procedures (such as pre-operative testing). The 30-day morbidity rates were similar to those reported pre-pandemic. These data will help facilitate the safe re-introduction of MBS services for this group of patients.

Published
2021

11. Global 30-day outcomes after bariatric surgery during the COVID-19 pandemic (GENEVA): an international cohort study

Author

Abou-Mrad-Fricquegnon, A, Alasfur, A, Alexandrou, A, Barbosa, A, Bashir, A, Bosco, A, Charalabopoulos, A, Curell, A, Davarpanah Jazi, A, Diego, A, Elghandour, A, Ergin, A, Garcia, A, Ghazal, A, Haddad, A, Ibarzábal, A, Khazraji, A, Lale, A, Lázaro, A, Leyva-Alvizo, A, Liagre, A, Maleckas, A, Osman, A, Pantelis, A, Pazouki, A, Plamper, A, Raziel, A, Rizzi, A, Sanchez, A, Sharma, A, Spaventa, A, Sumer, A, Torres, A, Türkçapar, A, Ugale, A, Velikorechin, A, Vitiello, A, Alkhaffaf, B, Bomans, B, Ammori, BJ, Pares, B, Smeu, B, Zilberstein, B, Boeker, C, Brodén, C, Copaescu, C, Guevara, C, Güldoğan, C, Kirkil, C, Matthys, C, Nagliati, C, Parmar, C, Trindade, C, Vaz, C, Wietzycoski, C, Zerrweck, C, Bedi, D, de Marchi, D, Faraj, D, Foschi, D, Goitein, D, Hazzan, D, Lapatsanis, D, Mazza, D, Mohammed, D, Padilla-Armendariz, D, Pennisi, D, Pham, D, Pournaras, D, Swank, D, Thakkar, D, Baena, E, Baili, E, Bastos, E, Dilektasli, E, Hazebroek, E, Kaplan, E, Lopes, E, Manno, E, Pinotti, E, Sdralis, E, Barrera-Rodriguez, F, Cantu, F, Jr., Frattini, F, Martini, F, Berardi, G, Cesana, G, Dapri, G, Dinescu, G, Juglard, G, Martinez de Aragon, G, Menaldi, G, Ören, G, Pavone, G, Rana, G, Vrakopoulou, G, Aboshanab, H, Al-Momani, H, Balamoun, H, Çiyiltepe, H, de Vasconcelos Cunha, H, Elghadban, H, Gislason, H, Hamed, H, Heneghan, H, Ibrahim, H, Melali, H, Reyes, H, Sebbag, H, Hakami, I, Hutopila, I, Balibrea, J, Bernardo, J, Campos, J, Chevallier, J, Dargent, J, Estrada, J, Gonzalez, J, Hewes, J, Himpens, J, Mall, J, Monterrubio, J, Pasquier, J, Albanopoulos, K, Bartosiak, K, Kaseja, K, Kumar, K, Rheinwalt, K, Shah, K, van de Pas, K., Angrisani, L, Benuzzi, L, Chong, L, Layani, L, Lee, L, Level, L, Taylor, L, Zinai, L, Akbaba, M, Alejandro, M, Altarawni, M, Beisani, M, Bertrand, M, Cantu, M, Dincer, M, Elbanna, M, Elfawal, M, Focquet, M, Forero, M, Hadad, M, Hii, M, Iovino, M, Islam, M, Josa, M, Kaplan, M, Kermansaravi, M, Khaitan, M, Kizilkaya, M, Kotowski, M, Montouri, M, Musella, M, Narwaria, M, Navarro, M, Niazi, M, Özmen, M, Qassem, M, Romeijn, M, Said, M, Salman, M, Solovyeva, M, Takieddine, M, Uccelli, M, Ustun, M, Valeti, M, Walędziak, M, Arora, N, Dukkipati, N, Fearon, N, Kiran, N, Paleari, N, Sakran, N, Silva, N, Tartaglia, N, Savas, O, Şen, O, Viveiros, O, Fabbri, P, García, P, Major, P, Martinez, P, Martinez Duartez, P, Salminen, P, Shah, P, Gadani, R, Gokay, R, Gudaityte, R, Kassir, R, Liem, R, Mohan, R, Palma, R, Quinino, R, Ribeiro, R, Vilallonga, R, Arana-Garza, S, Chiappetta, S, Davakis, S, Ghareeb, S, Gregorio, S, Khaldi, S, Martinez, S, Okkema, S, Olmi, S, Ortiz, S, Pinango, S, Shah, S, Shahabi, S, Taha, S, Ugale, S, Barreiro, T, Beck, T, Poghosyan, T, Samarkandy, T, Yigit, T, Borrelli, V, Bottino, V, Marco, V, Ormando, V, Pol, V, Sierra Esteban, V, Valentí, V, Leclercq, W, Souza, W, Vening, W, Vleeschouwers, W, van der Burgh, Y, Singhal, Rishi, Tahrani, Abd A, Ludwig, Christian, and Mahawar, Kamal

Published
2021
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12. 30-day morbidity and mortality of sleeve gastrectomy, Roux-en-Y gastric bypass and one anastomosis gastric bypass: a propensity score-matched analysis of the GENEVA data

Author

Singhal, R. Cardoso, V.R. Wiggins, T. Super, J. Ludwig, C. Gkoutos, G.V. Mahawar, K. Pędziwiatr, M. Major, P. Zarzycki, P. Pantelis, A. Lapatsanis, D.P. Stravodimos, G. Matthys, C. Focquet, M. Vleeschouwers, W. Spaventa, A.G. Zerrweck, C. Vitiello, A. Berardi, G. Musella, M. Sanchez-Meza, A. Cantu, F.J., Jr Mora, F. Cantu, M.A. Katakwar, A. Reddy, D.N. Elmaleh, H. Hassan, M. Elghandour, A. Elbanna, M. Osman, A. Khan, A. layani, L. Kiran, N. Velikorechin, A. Solovyeva, M. Melali, H. Shahabi, S. Agrawal, A. Shrivastava, A. Sharma, A. Narwaria, B. Narwaria, M. Raziel, A. Sakran, N. Susmallian, S. Karagöz, L. Akbaba, M. Pişkin, S.Z. Balta, A.Z. Senol, Z. Manno, E. Iovino, M.G. Osman, A. Qassem, M. Arana-Garza, S. Povoas, H.P. Vilas-Boas, M.L. Naumann, D. Li, A. Ammori, B.J. Balamoun, H. Salman, M. Nasta, A.M. Goel, R. Sánchez-Aguilar, H. Herrera, M.F. Abou-mrad, A. Cloix, L. Mazzini, G.S. Kristem, L. Lazaro, A. Campos, J. Bernardo, J. González, J. Trindade, C. Viveiros, O. Ribeiro, R. Goitein, D. Hazzan, D. Segev, L. Beck, T. Reyes, H. Monterrubio, J. García, P. Benois, M. Kassir, R. Contine, A. Elshafei, M. Aktas, S. Weiner, S. Heidsieck, T. Level, L. Pinango, S. Ortega, P.M. Moncada, R. Valenti, V. Vlahović, I. Boras, Z. Liagre, A. Martini, F. Juglard, G. Motwani, M. Saggu, S.S. Momani, H.A. López, L.A.A. Cortez, M.A.C. Zavala, R.A. D’Haese RN, C. Kempeneers, I. Himpens, J. Lazzati, A. Paolino, L. Bathaei, S. Bedirli, A. Yavuz, A. Büyükkasap, Ç. Özaydın, S. Kwiatkowski, A. Bartosiak, K. Walędziak, M. Santonicola, A. Angrisani, L. Iovino, P. Palma, R. Iossa, A. Boru, C.E. De Angelis, F. Silecchia, G. Hussain, A. Balchandra, S. Coltell, I.B. Pérez, J.L. Bohra, A. Awan, A.K. Madhok, B. Leeder, P.C. Awad, S. Al-Khyatt, W. Shoma, A. Elghadban, H. Ghareeb, S. Mathews, B. Kurian, M. Larentzakis, A. Vrakopoulou, G.Z. Albanopoulos, K. Bozdag, A. Lale, A. Kirkil, C. Dincer, M. Bashir, A. Haddad, A. Hijleh, L.A. Zilberstein, B. de Marchi, D.D. Souza, W.P. Brodén, C.M. Gislason, H. Shah, K. Ambrosi, A. Pavone, G. Tartaglia, N. Kona, S.L.K. Kalyan, K. Perez, C.E.G. Botero, M.A.F. Covic, A. Timofte, D. Maxim, M. Faraj, D. Tseng, L. Liem, R. Ören, G. Dilektasli, E. Yalcin, I. AlMukhtar, H. Hadad, M.A. Mohan, R. Arora, N. Bedi, D. Rives-Lange, C. Chevallier, J.-M. Poghosyan, T. Sebbag, H. Zinaï, L. Khaldi, S. Mauchien, C. Mazza, D. Dinescu, G. Rea, B. Pérez-Galaz, F. Zavala, L. Besa, A. Curell, A. Balibrea, J.M. Vaz, C. Galindo, L. Silva, N. Caballero, J.L.E. Sebastian, S.O. Marchesini, J.C.D. da Fonseca Pereira, R.A. Sobottka, W.H. Fiolo, F.E. Turchi, M. Coelho, A.C.J. Zacaron, A.L. Barbosa, A. Quinino, R. Menaldi, G. Paleari, N. Martinez-Duartez, P. de Esparza, G.M.A.R. Esteban, V.S. Torres, A. Garcia-Galocha, J.L. Josa, M. Pacheco-Garcia, J.M. Mayo-Ossorio, M.A. Chowbey, P. Soni, V. de Vasconcelos Cunha, H.A. Castilho, M.V. Ferreira, R.M.A. Barreiro, T.A. Charalabopoulos, A. Sdralis, E. Davakis, S. Bomans, B. Dapri, G. Van Belle, K. Takieddine, M. Vaneukem, P. Karaca, E.S.A. Karaca, F.C. Sumer, A. Peksen, C. Savas, O.A. Chousleb, E. Elmokayed, F. Fakhereldin, I. Aboshanab, H.M. Swelium, T. Gudal, A. Gamloo, L. Ugale, A. Ugale, S. Boeker, C. Reetz, C. Hakami, I.A. Mall, J. Alexandrou, A. Baili, E. Bodnar, Z. Maleckas, A. Gudaityte, R. Guldogan, C.E. Gundogdu, E. Ozmen, M.M. Thakkar, D. Dukkipati, N. Shah, P.S. Shah, S.S. Shah, S.S. Adil, M.T. Jambulingam, P. Mamidanna, R. Whitelaw, D. Adil, M.T. Jain, V. Veetil, D.K. Wadhawan, R. Torres, A. Torres, M. Tinoco, T. Leclercq, W. Romeijn, M. van de Pas, K. Alkhazraji, A.K. Taha, S.A. Ustun, M. Yigit, T. Inam, A. Burhanulhaq, M. Pazouki, A. Eghbali, F. Kermansaravi, M. Jazi, A.H.D. Mahmoudieh, M. Mogharehabed, N. Tsiotos, G. Stamou, K. Rodriguez, F.J.B. Navarro, M.A.R. Torres, O.M. Martinez, S.L. Tamez, E.R.M. Cornejo, G.A.M. Flores, J.E.G. Mohammed, D.A. Elfawal, M.H. Shabbir, A. Guowei, K. So, J.B. Kaplan, E.T. Kaplan, M. Kaplan, T. Pham, D.T. Rana, G. Kappus, M. Gadani, R. Kahitan, M. Pokharel, K. Osborne, A. Pournaras, D. Hewes, J. Napolitano, E. Chiappetta, S. Bottino, V. Dorado, E. Schoettler, A. Gaertner, D. Fedtke, K. Aguilar-Espinosa, F. Aceves-Lozano, S. Balani, A. Nagliati, C. Pennisi, D. Rizzi, A. Frattini, F. Foschi, D. Benuzzi, L. Parikh, C. Shah, H. Pinotti, E. Montuori, M. Borrelli, V. Dargent, J. Copaescu, C.A. Hutopila, I. Smeu, B. Witteman, B. Hazebroek, E. Deden, L. Heusschen, L. Okkema, S. Aufenacker, T. den Hengst, W. Vening, W. van der Burgh, Y. Ghazal, A. Ibrahim, H. Niazi, M. Alkhaffaf, B. Altarawni, M. Cesana, G.C. Anselmino, M. Uccelli, M. Olmi, S. Stier, C. Akmanlar, T. Sonnenberg, T. Schieferbein, U. Marcolini, A. Awruch, D. Vicentin, M. de Souza Bastos, E.L. Gregorio, S.A. Ahuja, A. Mittal, T. Bolckmans, R. Wiggins, T. Baratte, C. Wisnewsky, J.A. Genser, L. Chong, L. Taylor, L. Ward, S. Hi, M.W. Heneghan, H. Fearon, N. Plamper, A. Rheinwalt, K. Heneghan, H. Geoghegan, J. Ng, K.C. Fearon, N. Kaseja, K. Kotowski, M. Samarkandy, T.A. Leyva-Alvizo, A. Corzo-Culebro, L. Wang, C. Yang, W. Dong, Z. Riera, M. Jain, R. Hamed, H. Said, M. Zarzar, K. Garcia, M. Türkçapar, A.G. Şen, O. Baldini, E. Conti, L. Wietzycoski, C. Lopes, E. Pintar, T. Salobir, J. Aydin, C. Atici, S.D. Ergin, A. Ciyiltepe, H. Bozkurt, M.A. Kizilkaya, M.C. Onalan, N.B.D. Zuber, M.N.B.A. Wong, W.J. Garcia, A. Vidal, L. Beisani, M. Pasquier, J. Vilallonga, R. Sharma, S. Parmar, C. Lee, L. Sufi, P. Sinan, H. Saydam, M. GENEVA Collaborators

Subjects
nutritional and metabolic diseases
Abstract

Background: There is a paucity of data comparing 30-day morbidity and mortality of sleeve gastrectomy (SG), Roux-en-Y gastric bypass (RYGB), and one anastomosis gastric bypass (OAGB). This study aimed to compare the 30-day safety of SG, RYGB, and OAGB in propensity score-matched cohorts. Materials and methods: This analysis utilised data collected from the GENEVA study which was a multicentre observational cohort study of bariatric and metabolic surgery (BMS) in 185 centres across 42 countries between 01/05/2022 and 31/10/2020 during the Coronavirus Disease-2019 (COVID-19) pandemic. 30-day complications were categorised according to the Clavien–Dindo classification. Patients receiving SG, RYGB, or OAGB were propensity-matched according to baseline characteristics and 30-day complications were compared between groups. Results: In total, 6770 patients (SG 3983; OAGB 702; RYGB 2085) were included in this analysis. Prior to matching, RYGB was associated with highest 30-day complication rate (SG 5.8%; OAGB 7.5%; RYGB 8.0% (p = 0.006)). On multivariate regression modelling, Insulin-dependent type 2 diabetes mellitus and hypercholesterolaemia were associated with increased 30-day complications. Being a non-smoker was associated with reduced complication rates. When compared to SG as a reference category, RYGB, but not OAGB, was associated with an increased rate of 30-day complications. A total of 702 pairs of SG and OAGB were propensity score-matched. The complication rate in the SG group was 7.3% (n = 51) as compared to 7.5% (n = 53) in the OAGB group (p = 0.68). Similarly, 2085 pairs of SG and RYGB were propensity score-matched. The complication rate in the SG group was 6.1% (n = 127) as compared to 7.9% (n = 166) in the RYGB group (p = 0.09). And, 702 pairs of OAGB and RYGB were matched. The complication rate in both groups was the same at 7.5 % (n = 53; p = 0.07). Conclusions: This global study found no significant difference in the 30-day morbidity and mortality of SG, RYGB, and OAGB in propensity score-matched cohorts. © 2021, The Author(s).

Published
2021

13. Global 30-day outcomes after bariatric surgery during the COVID-19 pandemic (GENEVA): an international cohort study

Author

Singhal, Rishi, primary, Tahrani, Abd A, additional, Ludwig, Christian, additional, Mahawar, Kamal, additional, Abou-Mrad-Fricquegnon, A, additional, Alasfur, A, additional, Alexandrou, A, additional, Barbosa, A, additional, Bashir, A, additional, Bosco, A, additional, Charalabopoulos, A, additional, Curell, A, additional, Davarpanah Jazi, A, additional, Diego, A, additional, Elghandour, A, additional, Ergin, A, additional, Garcia, A, additional, Ghazal, A, additional, Haddad, A, additional, Ibarzábal, A, additional, Khazraji, A, additional, Lale, A, additional, Lázaro, A, additional, Leyva-Alvizo, A, additional, Liagre, A, additional, Maleckas, A, additional, Osman, A, additional, Pantelis, A, additional, Pazouki, A, additional, Plamper, A, additional, Raziel, A, additional, Rizzi, A, additional, Sanchez, A, additional, Sharma, A, additional, Spaventa, A, additional, Sumer, A, additional, Torres, A, additional, Türkçapar, A, additional, Ugale, A, additional, Velikorechin, A, additional, Vitiello, A, additional, Alkhaffaf, B, additional, Bomans, B, additional, Ammori, BJ, additional, Pares, B, additional, Smeu, B, additional, Zilberstein, B, additional, Boeker, C, additional, Brodén, C, additional, Copaescu, C, additional, Guevara, C, additional, Güldoğan, C, additional, Kirkil, C, additional, Matthys, C, additional, Nagliati, C, additional, Parmar, C, additional, Trindade, C, additional, Vaz, C, additional, Wietzycoski, C, additional, Zerrweck, C, additional, Bedi, D, additional, de Marchi, D, additional, Faraj, D, additional, Foschi, D, additional, Goitein, D, additional, Hazzan, D, additional, Lapatsanis, D, additional, Mazza, D, additional, Mohammed, D, additional, Padilla-Armendariz, D, additional, Pennisi, D, additional, Pham, D, additional, Pournaras, D, additional, Swank, D, additional, Thakkar, D, additional, Baena, E, additional, Baili, E, additional, Bastos, E, additional, Dilektasli, E, additional, Hazebroek, E, additional, Kaplan, E, additional, Lopes, E, additional, Manno, E, additional, Pinotti, E, additional, Sdralis, E, additional, Barrera-Rodriguez, F, additional, Cantu, F, additional, Frattini, F, additional, Martini, F, additional, Berardi, G, additional, Cesana, G, additional, Dapri, G, additional, Dinescu, G, additional, Juglard, G, additional, Martinez de Aragon, G, additional, Menaldi, G, additional, Ören, G, additional, Pavone, G, additional, Rana, G, additional, Vrakopoulou, G, additional, Aboshanab, H, additional, Al-Momani, H, additional, Balamoun, H, additional, Çiyiltepe, H, additional, de Vasconcelos Cunha, H, additional, Elghadban, H, additional, Gislason, H, additional, Hamed, H, additional, Heneghan, H, additional, Ibrahim, H, additional, Melali, H, additional, Reyes, H, additional, Sebbag, H, additional, Hakami, I, additional, Hutopila, I, additional, Balibrea, J, additional, Bernardo, J, additional, Campos, J, additional, Chevallier, J, additional, Dargent, J, additional, Estrada, J, additional, Gonzalez, J, additional, Hewes, J, additional, Himpens, J, additional, Mall, J, additional, Monterrubio, J, additional, Pasquier, J, additional, Albanopoulos, K, additional, Bartosiak, K, additional, Kaseja, K, additional, Kumar, K, additional, Rheinwalt, K, additional, Shah, K, additional, van de Pas, K., additional, Angrisani, L, additional, Benuzzi, L, additional, Chong, L, additional, Layani, L, additional, Lee, L, additional, Level, L, additional, Taylor, L, additional, Zinai, L, additional, Akbaba, M, additional, Alejandro, M, additional, Altarawni, M, additional, Beisani, M, additional, Bertrand, M, additional, Cantu, M, additional, Dincer, M, additional, Elbanna, M, additional, Elfawal, M, additional, Focquet, M, additional, Forero, M, additional, Hadad, M, additional, Hii, M, additional, Iovino, M, additional, Islam, M, additional, Josa, M, additional, Kaplan, M, additional, Kermansaravi, M, additional, Khaitan, M, additional, Kizilkaya, M, additional, Kotowski, M, additional, Montouri, M, additional, Musella, M, additional, Narwaria, M, additional, Navarro, M, additional, Niazi, M, additional, Özmen, M, additional, Qassem, M, additional, Romeijn, M, additional, Said, M, additional, Salman, M, additional, Solovyeva, M, additional, Takieddine, M, additional, Uccelli, M, additional, Ustun, M, additional, Valeti, M, additional, Walędziak, M, additional, Arora, N, additional, Dukkipati, N, additional, Fearon, N, additional, Kiran, N, additional, Paleari, N, additional, Sakran, N, additional, Silva, N, additional, Tartaglia, N, additional, Savas, O, additional, Şen, O, additional, Viveiros, O, additional, Fabbri, P, additional, García, P, additional, Major, P, additional, Martinez, P, additional, Martinez Duartez, P, additional, Salminen, P, additional, Shah, P, additional, Gadani, R, additional, Gokay, R, additional, Gudaityte, R, additional, Kassir, R, additional, Liem, R, additional, Mohan, R, additional, Palma, R, additional, Quinino, R, additional, Ribeiro, R, additional, Vilallonga, R, additional, Arana-Garza, S, additional, Chiappetta, S, additional, Davakis, S, additional, Ghareeb, S, additional, Gregorio, S, additional, Khaldi, S, additional, Martinez, S, additional, Okkema, S, additional, Olmi, S, additional, Ortiz, S, additional, Pinango, S, additional, Shah, S, additional, Shahabi, S, additional, Taha, S, additional, Ugale, S, additional, Barreiro, T, additional, Beck, T, additional, Poghosyan, T, additional, Samarkandy, T, additional, Yigit, T, additional, Borrelli, V, additional, Bottino, V, additional, Marco, V, additional, Ormando, V, additional, Pol, V, additional, Sierra Esteban, V, additional, Valentí, V, additional, Leclercq, W, additional, Souza, W, additional, Vening, W, additional, Vleeschouwers, W, additional, and van der Burgh, Y, additional

Published
2021
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19. Effectiveness of topical use of Lietofix® in wound healing after pilonidalis sinus excision: a multicenter study by the Italian Society of Colorectal Surgery (SICCR).

Author

Giannini, I., Andreoli, R., Bianchi, F. P., Cavallaro, V., Corno, F., Geccherle, A., Ghiglione, F., Legnaro, A., Losacco, L., Marola, S., Orlandi, S., Pecorella, G., Pennisi, D., Perinotti, R., Poli, F., Pozzo, M., Pulzato, L., Schembari, E., Tafuri, S., and Tegon, G.

Subjects
PROCTOLOGY, WOUND healing, POSTOPERATIVE pain treatment, SURGICAL excision
Published
2019
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20. Practice nurse involvement in the management of adults with type 2 diabetes mellitus attending a general practice: Results from a systematic review

Author

Parker, D, Maresco-Pennisi, D, Clifton, K, Shams, R, Young, J, Parker, D, Maresco-Pennisi, D, Clifton, K, Shams, R, and Young, J

Abstract

© 2016 University of Adelaide, Joanna Briggs Institute. Aim: Using the methodology of the Joanna Briggs Institute, a systematic review of current research was performed to determine if the addition of management by nurses had been more effective in improving clinical outcomes of patients with type 2 diabetes attending a general practice compared with standard care. Methods: A three-step literature search was conducted for suitable English studies with quantitative clinical outcomes that had been published from January 1990 to May 2014. Randomised controlled trials (RCTs) were particularly sought after; however, other research designs were considered. Articles were assessed by two independent reviewers for methodological validity, prior to inclusion in the review, using standardised critical appraisal instruments from the Joanna Briggs Institute. When possible, quantitative data were pooled in statistical meta-analysis. Results: Seven studies were of suitable quality and relevance for the review: these included three randomised control trials; two cluster- RCTs; a cluster, nonrandomised, controlled before-after study; and a cluster observational cohort study. These studies yield evidence that nurse management in addition to standard general practitioner care leads to modest improvements in blood pressure and total cholesterol levels in adults with type 2 diabetes attending a general practice. Conclusion: Meta-analysis identified modest, significant improvements amongst participants in nurse management interventions (NMIs) in the following clinical outcomes: mean SBP, mean DBP and mean total cholesterol. The majority of outcomes studied did not show any advantage to adding NMIs to general practitioner care. Two studies reported significant improvements of participants with poor control in mean haemoglobin A1c. An RCT that investigates the effect of NMIs on patients, with poor control in regard to clinical outcomes and cost effectiveness, is recommended.

Published
2016

21. Control of post-hemorrhoidectomy symptoms and wound healing by Triclosan: a randomized, double-blind, controlled trial

Author

Giannini, I., Pecorella, G., Pennisi, D., Santangelo, G., Digennaro, R., Latorre, F., Giuliani, G., and Donato Francesco Altomare

Subjects
Emorroidectomia, Adult, Hemorrhoidectomy, Male, Wound Healing, Adolescent, Middle Aged, Hemorrhoids, Triclosan, hemorrhoidectomy, Young Adult, Postoperative Complications, Double-Blind Method, Anti-Infective Agents, Local, Humans, Female, Prospective Studies, Aged
Abstract

Milligan-Morgan hemorrhoidectomy (MM) is still the most common treatment for grades III and IV hemorrhoids despite prolonged post-operative anal pain and wound healing. This multicenter, double blind, randomized, controlled trial was designed to assess the safety and the efficacy of anal wound cleansing with Triclosan (Proctocid®) in the control of symptoms and healing time after MM.A total of 113 patients with grades III and IV hemorrhoids, undergoing open hemorroidectomy by diathermy or Ligasure vessel sealing device, were randomly assigned to Triclosan or sodium hypochlorite solution. All patients received analgesics and a fiber-rich diet after hemorrhoidectomy. Postoperative anal pain, bleeding and/or secretion and itch were assessed 7, 14 and 21 days after hemorrhoidectomy by a Visual Analogue Scale (VAS) and the day of complete re-epithelialization of anal wounds was recorded.Fifty-five patients were randomized for Triclosan treatment and 58 for the control drug. The two groups were comparable for demographics, severity of hemorrhoids and technique used for the hemorrhoidectomy. The comparison of days to get complete anal wound healing shows a trend of significance (P=0.05) for the Triclosan group. Bleeding and/or secretion, anal pain and itch were significantly better (P=0.003; P0.0001 and P=0.01, respectively).Triclosan solution for the treatment of post-hemorrhoidectomy wounds is safe and improves the control of post-operative symptoms and wound healing time compared to sodium hypochlorite.

Published
2014

23. Mice null for Sox18 are viable and display a mild coat defect

Author

Pennisi, D. J., Bowles, Josephine, Nagy, Andras, Muscat, George, Koopman, Peter, Pennisi, D. J., Bowles, Josephine, Nagy, Andras, Muscat, George, and Koopman, Peter

Abstract

We have previously shown that Sox18 is expressed in developing vascular endothelium and hair follicles during mouse embryogenesis and that point mutations in Sox18 are the underlying cause of cardiovascular and hair follicle defects inragged (Ra) mice. Here we describe the analysis of Sox18 -/- mice produced by gene targeting. Despite the profound defects seen in Ra mice, Sox18 -/- mice have no obvious cardiovascular defects and only a mild coat defect with a reduced proportion of zigzag hairs. A reduction in the amount of pheomelanin pigmentation in hair shafts was also observed; later-forming hair follicles showed a reduced subapical pheomelanin band, giving Sox18 -/- mice a slightly darker appearance than Sox18 +/+- and Sox18 +/- siblings. Sox18 -/- mice are viable and fertile and show no difference in the ability to thrive relative to littermates. Because of the mild effect of the mutation on the phenotype of Sox18 -/- mice, we conclude that the semidominant nature of the Ra mutations is due to atrans-dominant negative effect mediated by the mutant SOX18 proteins rather than haploinsufficiency as has been observed for other SOX genes. Due to the similarity of SOX18 to other subgroup F SOX proteins, SOX7 and −17, and the overlap in expression of these genes, functional redundancy amongst these SOX proteins could also account for the mild phenotype of Sox18 -/- mice.

Published
2000

24. Mice null for sox18 are viable and display a mild coat defect.

Author

Pennisi, D, Bowles, J, Nagy, A, Muscat, G, and Koopman, P

Abstract

We have previously shown that Sox18 is expressed in developing vascular endothelium and hair follicles during mouse embryogenesis and that point mutations in Sox18 are the underlying cause of cardiovascular and hair follicle defects in ragged (Ra) mice. Here we describe the analysis of Sox18(-/-) mice produced by gene targeting. Despite the profound defects seen in Ra mice, Sox18(-/-) mice have no obvious cardiovascular defects and only a mild coat defect with a reduced proportion of zigzag hairs. A reduction in the amount of pheomelanin pigmentation in hair shafts was also observed; later-forming hair follicles showed a reduced subapical pheomelanin band, giving Sox18(-/-) mice a slightly darker appearance than Sox18(+/+) and Sox18(+/-) siblings. Sox18(-/-) mice are viable and fertile and show no difference in the ability to thrive relative to littermates. Because of the mild effect of the mutation on the phenotype of Sox18(-/-) mice, we conclude that the semidominant nature of the Ra mutations is due to a trans-dominant negative effect mediated by the mutant SOX18 proteins rather than haploinsufficiency as has been observed for other SOX genes. Due to the similarity of SOX18 to other subgroup F SOX proteins, SOX7 and -17, and the overlap in expression of these genes, functional redundancy amongst these SOX proteins could also account for the mild phenotype of Sox18(-/-) mice.

Published
2000

25. Targeted disruption of the Wnt2 gene results in placentation defects.

Author

Monkley, S J, Delaney, S J, Pennisi, D J, Christiansen, J H, and Wainwright, B J

Abstract

Wnt genes have been implicated in a range of developmental processes in the mouse including the patterning of the central nervous system and limbs. Reported here for the first time is the expression of Wnt2 in the early heart field of 7.5-8.5 dpc (days post-coitum) mouse embryos, making Wnt2 a potentially useful gene marker for the early stages of heart development. Expression was also detected in the allantois from 8.0 dpc and at later stages in the placenta and umbilicus. Mice deficient in Wnt2, generated by gene targeting, displayed runting and approximately 50% died perinatally. Histological analysis revealed alterations in the size and structure of placentas from these mice from 14.5 dpc. The placental defects were associated primarily with the labyrinthine zone and included oedema and tissue disruption and accumulation of maternal blood in large pools. There was also an apparent decrease in the number of foetal capillaries and an increase in the amount of fibrinoid material in the Wnt2 mutant placentas. These results suggest that Wnt2 is required for the proper vascularisation of the mouse placenta and the placental defects in Wnt2-deficient mice result in a reduction in birthweight and perinatal lethality.

Published
1996

26. Enhanced Recovery after Bariatric Surgery: 202 Consecutive Patients in an Italian Bariatric Center

Author

Carlo Nagliati, Marina Troian, Damiano Pennisi, Alessandro Balani, Nagliati, C., Troian, M., Pennisi, D., and Balani, A.

Subjects
Male, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Bariatric Surgery, Postoperative Complications, 0302 clinical medicine, ERAS, Prospective Studies, Sleeve gastrectomy, Young adult, Prospective cohort study, Laparoscopic sleeve gastrectomy, Nutrition and Dietetics, LOS, Middle Aged, Readmission rate, Italy, Female, 030211 gastroenterology & hepatology, Enhanced Recovery After Surgery, Human, Adult, medicine.medical_specialty, Roux-en-Y gastric bypass, 030209 endocrinology & metabolism, Patient Readmission, Young Adult, 03 medical and health sciences, RYGB, Enhanced recovery, medicine, SG, Humans, Enhanced recovery after surgery, Aged, Enhanced recovery after bariatric surgery, business.industry, Postoperative complication, Bariatric surgery, ERABS, Length of stay, Feasibility Studies, Length of Stay, Surgery, Feasibility Studie, Prospective Studie, Roux-en-Y gastric bypa, Postoperative Complication, business
Abstract

Background: Enhanced Recovery After Surgery (ERAS) pathways have been shown to improve postoperative outcomes. However, its application in bariatric surgery is still limited. The aim of the study was to define the safety of ERAS in bariatric patients with regard to postoperative complications, length of hospital stay (LOS), and readmission rates within 30 days from surgery. Methods: The effectiveness and safety of an ERAS protocol was prospectively investigated in morbidly obese patients who underwent bariatric surgery in a single-institute experience over a 2-year period. Results: Between June 2016 and September 2018, a total of 89 laparoscopic sleeve gastrectomy (SG), 105 Roux-en-Y gastric bypass (RYGB), and 8 one-anastomosis gastric bypass (OAGB) were performed. Twenty patients (9.9%) were revisional cases. Mean (standard deviation, SD) BMI and age at time of surgery were 43.2 (± 6.2) kg/m2 and 46 (± 11.3) years, respectively. Median (range) surgical time was 118 (45–255) minutes. Overall postoperative complication rate was 7.4%, with 6 (3.0%) patients developing grade III–IV complications according to the Clavien-Dindo classification. Median (range) LOS was 2 (1–50) days, with mean (SD) LOS of 2.3 (± 3.6) days. Overall, 36.6% of patients were discharged by first postoperative day and 77.7% by second postoperative day. Readmission rate was 4.5%. No mortality was observed during the study period. Conclusions: According to the results of the present study, ERAS in primary and revisional bariatric surgery is safe and feasible, with short LOS, low morbidity and readmission rates, and no mortality. A significant reduction of mean LOS was progressively noted over the study period.

Published
2019

27. Global 30-day outcomes after bariatric surgery during the COVID-19 pandemic (GENEVA): an international cohort study

Author

Rishi Singhal, Abd A Tahrani, Christian Ludwig, Kamal Mahawar, A Abou-Mrad-Fricquegnon, A Alasfur, A Alexandrou, A Barbosa, A Bashir, A Bosco, A Charalabopoulos, A Curell, A Davarpanah Jazi, A Diego, A Elghandour, A Ergin, A Garcia, A Ghazal, A Haddad, A Ibarzábal, A Khazraji, A Lale, A Lázaro, A Leyva-Alvizo, A Liagre, A Maleckas, A Osman, A Pantelis, A Pazouki, A Plamper, A Raziel, A Rizzi, A Sanchez, A Sharma, A Spaventa, A Sumer, A Torres, A Türkçapar, A Ugale, A Velikorechin, A Vitiello, B Alkhaffaf, B Bomans, BJ Ammori, B Pares, B Smeu, B Zilberstein, C Boeker, C Brodén, C Copaescu, C Guevara, C Güldoğan, C Kirkil, C Matthys, C Nagliati, C Parmar, C Trindade, C Vaz, C Wietzycoski, C Zerrweck, D Bedi, D de Marchi, D Faraj, D Foschi, D Goitein, D Hazzan, D Lapatsanis, D Mazza, D Mohammed, D Padilla-Armendariz, D Pennisi, D Pham, D Pournaras, D Swank, D Thakkar, E Baena, E Baili, E Bastos, E Dilektasli, E Hazebroek, E Kaplan, E Lopes, E Manno, E Pinotti, E Sdralis, F Barrera-Rodriguez, F Cantu, F Frattini, F Martini, G Berardi, G Cesana, G Dapri, G Dinescu, G Juglard, G Martinez de Aragon, G Menaldi, G Ören, G Pavone, G Rana, G Vrakopoulou, H Aboshanab, H Al-Momani, H Balamoun, H Çiyiltepe, H de Vasconcelos Cunha, H Elghadban, H Gislason, H Hamed, H Heneghan, H Ibrahim, H Melali, H Reyes, H Sebbag, I Hakami, I Hutopila, J Balibrea, J Bernardo, J Campos, J Chevallier, J Dargent, J Estrada, J Gonzalez, J Hewes, J Himpens, J Mall, J Monterrubio, J Pasquier, K Albanopoulos, K Bartosiak, K Kaseja, K Kumar, K Rheinwalt, K Shah, K. van de Pas, L Angrisani, L Benuzzi, L Chong, L Layani, L Lee, L Level, L Taylor, L Zinai, M Akbaba, M Alejandro, M Altarawni, M Beisani, M Bertrand, M Cantu, M Dincer, M Elbanna, M Elfawal, M Focquet, M Forero, M Hadad, M Hii, M Iovino, M Islam, M Josa, M Kaplan, M Kermansaravi, M Khaitan, M Kizilkaya, M Kotowski, M Montouri, M Musella, M Narwaria, M Navarro, M Niazi, M Özmen, M Qassem, M Romeijn, M Said, M Salman, M Solovyeva, M Takieddine, M Uccelli, M Ustun, M Valeti, M Walędziak, N Arora, N Dukkipati, N Fearon, N Kiran, N Paleari, N Sakran, N Silva, N Tartaglia, O Savas, O Şen, O Viveiros, P Fabbri, P García, P Major, P Martinez, P Martinez Duartez, P Salminen, P Shah, R Gadani, R Gokay, R Gudaityte, R Kassir, R Liem, R Mohan, R Palma, R Quinino, R Ribeiro, R Vilallonga, S Arana-Garza, S Chiappetta, S Davakis, S Ghareeb, S Gregorio, S Khaldi, S Martinez, S Okkema, S Olmi, S Ortiz, S Pinango, S Shah, S Shahabi, S Taha, S Ugale, T Barreiro, T Beck, T Poghosyan, T Samarkandy, T Yigit, V Borrelli, V Bottino, V Marco, V Ormando, V Pol, V Sierra Esteban, V Valentí, W Leclercq, W Souza, W Vening, W Vleeschouwers, Y van der Burgh, Singhal, R., Tahrani, A. A., Ludwig, C., Mahawar, K., Abou-Mrad-Fricquegnon, A., Alasfur, A., Alexandrou, A., Barbosa, A., Bashir, A., Bosco, A., Charalabopoulos, A., Curell, A., Davarpanah Jazi, A., Diego, A., Elghandour, A., Ergin, A., Garcia, A., Ghazal, A., Haddad, A., Ibarzabal, A., Khazraji, A., Lale, A., Lazaro, A., Leyva-Alvizo, A., Liagre, A., Maleckas, A., Osman, A., Pantelis, A., Pazouki, A., Plamper, A., Raziel, A., Rizzi, A., Sanchez, A., Sharma, A., Spaventa, A., Sumer, A., Torres, A., Turkcapar, A., Ugale, A., Velikorechin, A., Vitiello, A., Alkhaffaf, B., Bomans, B., Ammori, B. J., Pares, B., Smeu, B., Zilberstein, B., Boeker, C., Broden, C., Copaescu, C., Guevara, C., Guldogan, C., Kirkil, C., Matthys, C., Nagliati, C., Parmar, C., Trindade, C., Vaz, C., Wietzycoski, C., Zerrweck, C., Bedi, D., de Marchi, D., Faraj, D., Foschi, D., Goitein, D., Hazzan, D., Lapatsanis, D., Mazza, D., Mohammed, D., Padilla-Armendariz, D., Pennisi, D., Pham, D., Pournaras, D., Swank, D., Thakkar, D., Baena, E., Baili, E., Bastos, E., Dilektasli, E., Hazebroek, E., Kaplan, E., Lopes, E., Manno, E., Pinotti, E., Sdralis, E., Barrera-Rodriguez, F., Cantu, F., Frattini, F., Martini, F., Berardi, G., Cesana, G., Dapri, G., Dinescu, G., Juglard, G., Martinez de Aragon, G., Menaldi, G., Oren, G., Pavone, G., Rana, G., Vrakopoulou, G., Aboshanab, H., Al-Momani, H., Balamoun, H., Ciyiltepe, H., de Vasconcelos Cunha, H., Elghadban, H., Gislason, H., Hamed, H., Heneghan, H., Ibrahim, H., Melali, H., Reyes, H., Sebbag, H., Hakami, I., Hutopila, I., Balibrea, J., Bernardo, J., Campos, J., Chevallier, J., Dargent, J., Estrada, J., Gonzalez, J., Hewes, J., Himpens, J., Mall, J., Monterrubio, J., Pasquier, J., Albanopoulos, K., Bartosiak, K., Kaseja, K., Kumar, K., Rheinwalt, K., Shah, K., van de Pas, K., Angrisani, L., Benuzzi, L., Chong, L., Layani, L., Lee, L., Level, L., Taylor, L., Zinai, L., Akbaba, M., Alejandro, M., Altarawni, M., Beisani, M., Bertrand, M., Cantu, M., Dincer, M., Elbanna, M., Elfawal, M., Focquet, M., Forero, M., Hadad, M., Hii, M., Iovino, M., Islam, M., Josa, M., Kaplan, M., Kermansaravi, M., Khaitan, M., Kizilkaya, M., Kotowski, M., Montouri, M., Musella, M., Narwaria, M., Navarro, M., Niazi, M., Ozmen, M., Qassem, M., Romeijn, M., Said, M., Salman, M., Solovyeva, M., Takieddine, M., Uccelli, M., Ustun, M., Valeti, M., Waledziak, M., Arora, N., Dukkipati, N., Fearon, N., Kiran, N., Paleari, N., Sakran, N., Silva, N., Tartaglia, N., Savas, O., Sen, O., Viveiros, O., Fabbri, P., Garcia, P., Major, P., Martinez, P., Martinez Duartez, P., Salminen, P., Shah, P., Gadani, R., Gokay, R., Gudaityte, R., Kassir, R., Liem, R., Mohan, R., Palma, R., Quinino, R., Ribeiro, R., Vilallonga, R., Arana-Garza, S., Chiappetta, S., Davakis, S., Ghareeb, S., Gregorio, S., Khaldi, S., Martinez, S., Okkema, S., Olmi, S., Ortiz, S., Pinango, S., Shah, S., Shahabi, S., Taha, S., Ugale, S., Barreiro, T., Beck, T., Poghosyan, T., Samarkandy, T., Yigit, T., Borrelli, V., Bottino, V., Marco, V., Ormando, V., Pol, V., Sierra Esteban, V., Valenti, V., Leclercq, W., Souza, W., Vening, W., Vleeschouwers, W., and van der Burgh, Y.

Subjects
2019-20 coronavirus outbreak, medicine.medical_specialty, Internationality, Time Factors, Coronavirus disease 2019 (COVID-19), Time Factor, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Endocrinology, Diabetes and Metabolism, MEDLINE, Bariatric Surgery, Global Health, Cohort Studies, Endocrinology, Pandemic, Correspondence, medicine, Global health, Internal Medicine, Humans, Mortality, Mortality trends, Pandemics, Manchester Cancer Research Centre, business.industry, ResearchInstitutes_Networks_Beacons/mcrc, COVID-19, Treatment Outcome, Emergency medicine, Cohort Studie, business, Cohort study, Human
Published
2021
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28. Totally Laparoscopic Transgastric Resection of a Gastric Submucosal Fibrolipoma and Concomitant Sleeve Gastrectomy in a Morbidly Obese Patient

Author

Carlo Nagliati, Marina Troian, Alessandro Balani, Damiano Pennisi, Pennisi, D., Troian, M., Nagliati, C., and Balani, A.

Subjects
Sleeve gastrectomy, medicine.medical_specialty, Concomitant, Transgastric resection, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Submucosal Lesion, Resection, Lesion, Gastrectomy, Medicine, Humans, Gastric lipoma, Obesity, Laparoscopy, Bariatric surgery, Nutrition and Dietetics, Fibrolipoma, medicine.diagnostic_test, business.industry, Stomach, Curvatures of the stomach, Surgery, Obesity, Morbid, Treatment Outcome, medicine.symptom, business
Abstract

Introduction To evaluate feasibility and safety of a totally laparoscopic transgastric resection with concomitant sleeve gastrectomy in a morbidly obese presenting with benign lesion located along the lesser gastric curvature. Materials and methods We report the case of a morbidly obese patient with an incidental submucosal lesion of the lesser curvature radiologically consistent with fibrolipoma at preoperative work-up. Benign nature of the mass was then confirmed EUS-biopsy. Results A combinated laparoscopic transgastric approach was successfully attempted resulting in a complete excision of the submucosal lesion and concomitant sleeve gastrectomy. Intraoperative and definitive histology confirmed the benign nature of the mass. Postoperative course was uneventful. Conclusion Concomitant transgastric resection of submucosal benign lesions during laparoscopic sleeve gastrectomy represents both a safe and feasible surgical approach in morbidly obese patients. Preoperative work-up is of great importance in order to assess the benign nature of the lesion.

Published
2020

29. Correction to: Laparoscopic right hemicolectomy: the SICE (Società Italiana di Chirurgia Endoscopica e Nuove Tecnologie) network prospectivetrial on 1225 cases comparing intra corporeal versus extra corporeal ileo‑colic side‑to‑side anastomosis (Surgical Endoscopy, (2019), 10.1007/s00464-019-07255-2)

Author

M. Sorrentino, A. Alo, G. L. Canu, F. Monari, A. G. Marrosu, E. Soligo, Wanda Petz, A. Gattolin, R. Vicentini, S. Razzi, M. Zago, S. Neri, A. Pisani Ceretti, D. Apa, F. Gatti, A. Donini, F. Medas, D. Cassetti, S. Rubino, R. Lombardi, G. D. DePalma, Alberto Arezzo, G. Soliani, P. Checcacci, G. Concone, Emanuele Botteri, F. Scognamillo, Ferdinando Agresta, Pierluigi Marini, S. Gelati, Luigi Boni, A. Coratti, Andrea Picchetto, G. Guerriero, M. Calgaro, Francesca Pecchini, A. Contine, Andrea Valeri, N. DeManzini, M. Clementi, A. Balani, F. Fidanza, R. Galleano, Carlo Bergamini, A. Brescia, G. Arcuri, Elio Jovine, E. Rosso, A. Oldani, E. Artioli, Nereo Vettoretto, Giuseppe Navarra, G. Sarro, E. Restini, Chiara Morotti, S. Giannessi, F. DeAngelis, M. Degiuli, G. Talamo, G. Alemanno, L. Cafagna, P. Cumbo, V. Violi, S. Targa, Irnerio Angelo Muttillo, A. Martino, M. DeLuca, Elisa Cassinotti, Alessandro Puzziello, S. Sala, Riccardo Rosati, E. Erdas, R. Petri, A. Deserra, A. Gioffre, G. Viola, E. Stratta, Mario Guerrieri, E. Minciotti, Mauro Podda, Giuseppe Spinoglio, F. Borghi, Micaela Piccoli, C. DeNisco, P. Carcoforo, D. Delogu, Giuseppe Resta, P. Corleone, D. Pennisi, Gianfranco Silecchia, E. Opocher, A. Taddei, A. Budassi, Paolo Delrio, A. Meloni, Marco E. Allaix, A. Ambrosi, H. Impellizzeri, N. Portolani, L. Guerriero, G. Ercolani, A. Guariniello, M. Antoniutti, M. Cesari, A. P. Luzzi, M. Izzo, M. Longoni, R. Mazza, C. Benvenuto, S. Gobbi, P. G. Calo, C. Feo, Antonino Agrusa, L. Covotta, L. Presenti, V. Adamo, Gian Luca Baiocchi, E. Osenda, R. Ottonello, Giancarlo D'Ambrosio, F. Roviello, V. Grammatico, G. Moretto, L. Zampino, Valerio Caracino, Giovanni Ferrari, D. Rega, V. Robustelli, Diego Cuccurullo, F. Vasta, Ugo Elmore, R. Campagnacci, Gianfranco Cocorullo, O. Ghazouani, G. Ricci, S. Berti, F. Colombo, Alberto Sartori, S. Scabini, S. Mazzoccato, B. Pirrera, A. Altamura, N. Tartaglia, E. Romairone, G. Baldazzi, Marco Catarci, G. Garulli, Lorenzo Casali, S. Testa, R. Brachet Contul, M. Basti, U. Rivolta, D. Pertile, M. Pavanello, M. Pisano, Marco Milone, A. Verzelli, P. Ubiali, L. Solaini, M. Coppola, G Anania, Massimo Carlini, F. Corcione, P. DePaolis, P. Ciano, M. Santarelli, V. Panebianco, Nicola Perrotta, R. Sechi, M. Rigamonti, G. Lezoche, L. Fabris, C. Lirusso, D. Foschi, G. Canova, P. Soliani, Roberta Gelmini, Stefano Olmi, A. Lucchi, Giorgia Valpiani, L. Pellegrino, Anania, G., Agresta, F., Artioli, E., Rubino, S., Resta, G., Vettoretto, N., Petz, W. L., Bergamini, C., Arezzo, A., Valpiani, G., Morotti, C., Silecchia, G., Adamo, V., Agrusa, A., Alemanno, G., Allaix, M. E., Alo, A., Altamura, A., Ambrosi, A., Antoniutti, M., Apa, D., Arcuri, G., Baiocchi, G. L., Balani, A., Baldazzi, G., Basti, M., Benvenuto, C., Berti, S., Boni, L., Borghi, F., Botteri, E., Brachet Contul, R., Brescia, A., Budassi, A., Cafagna, L., Calgaro, M., Calo, P. G., Campagnacci, R., Canova, G., Canu, G. L., Caracino, V., Carcoforo, P., Carlini, M., Casali, L., Cassetti, D., Cassinotti, E., Catarci, M., Cesari, M., Checcacci, P., Ciano, P., Clementi, M., Cocorullo, G., Colombo, F., Concone, G., Contine, A., Coppola, M., Coratti, A., Corcione, F., Corleone, P., Covotta, L., Cuccurullo, D., Cumbo, P., D'Ambrosio, G., Deangelis, F., Deluca, M., Demanzini, N., Denisco, C., Depalma, G. D., Depaolis, P., Degiuli, M., Delogu, D., Delrio, P., Deserra, A., Donini, A., Elmore, U., Ercolani, G., Erdas, E., Fabris, L., Ferrari, G., Feo, C., Fidanza, F., Foschi, D., Galleano, R., Garulli, G., Gatti, F., Gattolin, A., Gelati, S., Gelmini, R., Ghazouani, O., Gioffre, A., Gobbi, S., Grammatico, V., Guariniello, A., Giannessi, S., Guerrieri, M., Guerriero, L., Guerriero, G., Impellizzeri, H., Izzo, M., Jovine, E., Lezoche, G., Lirusso, C., Lombardi, R., Longoni, M., Lucchi, A., Luzzi, A. P., Marini, P., Marrosu, A. G., Martino, A., Mazza, R., Mazzoccato, S., Medas, F., Meloni, A., Milone, M., Minciotti, E., Monari, F., Moretto, G., Muttillo, I. A., Navarra, G., Neri, S., Oldani, A., Olmi, S., Opocher, E., Osenda, E., Ottonello, R., Panebianco, V., Pavanello, M., Pecchini, F., Pellegrino, L., Pennisi, D., Perrotta, N., Pertile, D., Petri, R., Picchetto, A., Piccoli, M., Pirrera, B., Pisani Ceretti, A., Pisano, M., Podda, M., Portolani, N., Presenti, L., Puzziello, A., Razzi, S., Rega, D., Restini, E., Ricci, G., Rigamonti, M., Rivolta, U., Robustelli, V., Romairone, E., Rosati, R., Rosso, E., Roviello, F., Sala, S., Santarelli, M., Sarro, G., Sartori, A., Scabini, S., Scognamillo, F., Sechi, R., Solaini, L., Soliani, G., Soliani, P., Soligo, E., Sorrentino, M., Spinoglio, G., Stratta, E., Taddei, A., Talamo, G., Targa, S., Tartaglia, N., Testa, S., Ubiali, P., Valeri, A., Vasta, F., Verzelli, A., Vicentini, R., Viola, G., Violi, V., Zago, M., and Zampino, L.

Subjects
medicine.medical_specialty, colon cancer right hemcolectomy, business.industry, medicine, Surgery, business, Side to side anastomosis, Surgical endoscopy, Laparoscopic right hemicolectomy, NO, LS7_4
Abstract

Due to an error in production the members of SICE CoDIG (Colon Dx Italian Group) listed in the Acknowledgments were not tagged correctly as authors in the XML of this article. This listing is presented again here:.

Published
2019

30. Lactobacillus rhamnosus dampens cytokine and chemokine secretion from primary human nasal epithelial cells infected with rhinovirus.

Author

Yarlagadda T, Zhu Y, Snape N, Carey A, Bryan E, Maresco-Pennisi D, Coleman A, Cervin A, and Spann K

Subjects
Adult, Humans, Cytokines, Rhinovirus physiology, Cells, Cultured, Epithelial Cells, Inflammation, Chemokines pharmacology, Inflammation Mediators pharmacology, Lacticaseibacillus rhamnosus, Enterovirus Infections
Abstract

Aims: To investigate the effect of Lactobacillus rhamnosus on viral replication and cellular response to human rhinovirus (HRV) infection, including the secretion of antiviral and inflammatory mediators from well-differentiated nasal epithelial cells (WD-NECs)., Methods and Results: The WD-NECs from healthy adult donors (N = 6) were cultured in vitro, exposed to different strains of L. rhamnosus (D3189, D3160, or LB21), and infected with HRV (RV-A16) after 24 h. Survival and adherence capacity of L. rhamnosus in a NEC environment were confirmed using CFSE-labelled isolates, immunofluorescent staining, and confocal microscopy. Shed virus and viral replication were quantified using TCID50 assays and RT-qPCR, respectively. Cytotoxicity was measured by lactate dehydrogenase (LDH) activity. Pro-inflammatory mediators were measured by multiplex immunoassay, and interferon (IFN)-λ1/3 was measured using a standard ELISA kit. Lactobacillus rhamnosus was able to adhere to and colonize WD-NECs prior to the RV-A16 infection. Lactobacillus rhamnosus did not affect shed RV-A16, viral replication, RV-A16-induced IFN-λ1/3 production, or LDH release. Pre-exposure to L. rhamnosus, particularly D3189, reduced the secretion of RV-A16-induced pro-inflammatory mediators by WD-NECs., Conclusions: These findings demonstrate that L. rhamnosus differentially modulates RV-A16-induced innate inflammatory immune responses in primary NECs from healthy adults., (© The Author(s) 2024. Published by Oxford University Press on behalf of Applied Microbiology International.)

Published
2024
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32. 30-Day Morbidity and Mortality of Bariatric Surgery During the COVID-19 Pandemic: a Multinational Cohort Study of 7704 Patients from 42 Countries.

Author

Singhal R, Ludwig C, Rudge G, Gkoutos GV, Tahrani A, Mahawar K, Pędziwiatr M, Major P, Zarzycki P, Pantelis A, Lapatsanis DP, Stravodimos G, Matthys C, Focquet M, Vleeschouwers W, Spaventa AG, Zerrweck C, Vitiello A, Berardi G, Musella M, Sanchez-Meza A, Cantu FJ Jr, Mora F, Cantu MA, Katakwar A, Reddy DN, Elmaleh H, Hassan M, Elghandour A, Elbanna M, Osman A, Khan A, Layani L, Kiran N, Velikorechin A, Solovyeva M, Melali H, Shahabi S, Agrawal A, Shrivastava A, Sharma A, Narwaria B, Narwaria M, Raziel A, Sakran N, Susmallian S, Karagöz L, Akbaba M, Pişkin SZ, Balta AZ, Senol Z, Manno E, Iovino MG, Osman A, Qassem M, Arana-Garza S, Povoas HP, Vilas-Boas ML, Naumann D, Super J, Li A, Ammori BJ, Balamoun H, Salman M, Nasta AM, Goel R, Sánchez-Aguilar H, Herrera MF, Abou-Mrad A, Cloix L, Mazzini GS, Kristem L, Lazaro A, Campos J, Bernardo J, González J, Trindade C, Viveiros O, Ribeiro R, Goitein D, Hazzan D, Segev L, Beck T, Reyes H, Monterrubio J, García P, Benois M, Kassir R, Contine A, Elshafei M, Aktas S, Weiner S, Heidsieck T, Level L, Pinango S, Ortega PM, Moncada R, Valenti V, Vlahović I, Boras Z, Liagre A, Martini F, Juglard G, Motwani M, Saggu SS, Al Moman H, López LAA, Cortez MAC, Zavala RA, D'Haese C, Kempeneers I, Himpens J, Lazzati A, Paolino L, Bathaei S, Bedirli A, Yavuz A, Büyükkasap Ç, Özaydın S, Kwiatkowski A, Bartosiak K, Walędziak M, Santonicola A, Angrisani L, Iovino P, Palma R, Iossa A, Boru CE, De Angelis F, Silecchia G, Hussain A, Balchandra S, Coltell IB, Pérez JL, Bohra A, Awan AK, Madhok B, Leeder PC, Awad S, Al-Khyatt W, Shoma A, Elghadban H, Ghareeb S, Mathews B, Kurian M, Larentzakis A, Vrakopoulou GZ, Albanopoulos K, Bozdag A, Lale A, Kirkil C, Dincer M, Bashir A, Haddad A, Hijleh LA, Zilberstein B, de Marchi DD, Souza WP, Brodén CM, Gislason H, Shah K, Ambrosi A, Pavone G, Tartaglia N, Kona SLK, Kalyan K, Perez CEG, Botero MAF, Covic A, Timofte D, Maxim M, Faraj D, Tseng L, Liem R, Ören G, Dilektasli E, Yalcin I, AlMukhtar H, Al Hadad M, Mohan R, Arora N, Bedi D, Rives-Lange C, Chevallier JM, Poghosyan T, Sebbag H, Zinaï L, Khaldi S, Mauchien C, Mazza D, Dinescu G, Rea B, Pérez-Galaz F, Zavala L, Besa A, Curell A, Balibrea JM, Vaz C, Galindo L, Silva N, Caballero JLE, Sebastian SO, Marchesini JCD, da Fonseca Pereira RA, Sobottka WH, Fiolo FE, Turchi M, Coelho ACJ, Zacaron AL, Barbosa A, Quinino R, Menaldi G, Paleari N, Martinez-Duartez P, de Aragon Ramírez de Esparza GM, Esteban VS, Torres A, Garcia-Galocha JL, Josa M, Pacheco-Garcia JM, Mayo-Ossorio MA, Chowbey P, Soni V, de Vasconcelos Cunha HA, Castilho MV, Ferreira RMA, Barreiro TA, Charalabopoulos A, Sdralis E, Davakis S, Bomans B, Dapri G, Van Belle K, Takieddine M, Vaneukem P, Karaca ESA, Karaca FC, Sumer A, Peksen C, Savas OA, Chousleb E, Elmokayed F, Fakhereldin I, Aboshanab HM, Swelium T, Gudal A, Gamloo L, Ugale A, Ugale S, Boeker C, Reetz C, Hakami IA, Mall J, Alexandrou A, Baili E, Bodnar Z, Maleckas A, Gudaityte R, Guldogan CE, Gundogdu E, Ozmen MM, Thakkar D, Dukkipati N, Shah PS, Shah SS, Shah SS, Adil MT, Jambulingam P, Mamidanna R, Whitelaw D, Adil MT, Jain V, Veetil DK, Wadhawan R, Torres A, Torres M, Tinoco T, Leclercq W, Romeijn M, van de Pas K, Alkhazraji AK, Taha SA, Ustun M, Yigit T, Inam A, Burhanulhaq M, Pazouki A, Eghbali F, Kermansaravi M, Jazi AHD, Mahmoudieh M, Mogharehabed N, Tsiotos G, Stamou K, Barrera Rodriguez FJ, Rojas Navarro MA, Torres OM, Martinez SL, Tamez ERM, Millan Cornejo GA, Flores JEG, Mohammed DA, Elfawal MH, Shabbir A, Guowei K, So JB, Kaplan ET, Kaplan M, Kaplan T, Pham D, Rana G, Kappus M, Gadani R, Kahitan M, Pokharel K, Osborne A, Pournaras D, Hewes J, Napolitano E, Chiappetta S, Bottino V, Dorado E, Schoettler A, Gaertner D, Fedtke K, Aguilar-Espinosa F, Aceves-Lozano S, Balani A, Nagliati C, Pennisi D, Rizzi A, Frattini F, Foschi D, Benuzzi L, Parikh C, Shah H, Pinotti E, Montuori M, Borrelli V, Dargent J, Copaescu CA, Hutopila I, Smeu B, Witteman B, Hazebroek E, Deden L, Heusschen L, Okkema S, Aufenacker T, den Hengst W, Vening W, van der Burgh Y, Ghazal A, Ibrahim H, Niazi M, Alkhaffaf B, Altarawni M, Cesana GC, Anselmino M, Uccelli M, Olmi S, Stier C, Akmanlar T, Sonnenberg T, Schieferbein U, Marcolini A, Awruch D, Vicentin M, de Souza Bastos EL, Gregorio SA, Ahuja A, Mittal T, Bolckmans R, Wiggins T, Baratte C, Wisnewsky JA, Genser L, Chong L, Taylor L, Ward S, Chong L, Taylor L, Hi MW, Heneghan H, Fearon N, Plamper A, Rheinwalt K, Heneghan H, Geoghegan J, Ng KC, Fearon N, Kaseja K, Kotowski M, Samarkandy TA, Leyva-Alvizo A, Corzo-Culebro L, Wang C, Yang W, Dong Z, Riera M, Jain R, Hamed H, Said M, Zarzar K, Garcia M, Türkçapar AG, Şen O, Baldini E, Conti L, Wietzycoski C, Lopes E, Pintar T, Salobir J, Aydin C, Atici SD, Ergin A, Ciyiltepe H, Bozkurt MA, Kizilkaya MC, Onalan NBD, Zuber MNBA, Wong WJ, Garcia A, Vidal L, Beisani M, Pasquier J, Vilallonga R, Sharma S, Parmar C, Lee L, Sufi P, Sinan H, and Saydam M

Subjects
COVID-19 Testing, Cohort Studies, Humans, Incidence, Pandemics, Postoperative Complications epidemiology, SARS-CoV-2, Bariatric Surgery, COVID-19, Diabetes Mellitus, Type 2, Obesity, Morbid surgery
Abstract

Background: There are data on the safety of cancer surgery and the efficacy of preventive strategies on the prevention of postoperative symptomatic COVID-19 in these patients. But there is little such data for any elective surgery. The main objectives of this study were to examine the safety of bariatric surgery (BS) during the coronavirus disease 2019 (COVID-19) pandemic and to determine the efficacy of perioperative COVID-19 protective strategies on postoperative symptomatic COVID-19 rates., Methods: We conducted an international cohort study to determine all-cause and COVID-19-specific 30-day morbidity and mortality of BS performed between 01/05/2020 and 31/10/2020., Results: Four hundred ninety-nine surgeons from 185 centres in 42 countries provided data on 7704 patients. Elective primary BS (n = 7084) was associated with a 30-day morbidity of 6.76% (n = 479) and a 30-day mortality of 0.14% (n = 10). Emergency BS, revisional BS, insulin-treated type 2 diabetes, and untreated obstructive sleep apnoea were associated with increased complications on multivariable analysis. Forty-three patients developed symptomatic COVID-19 postoperatively, with a higher risk in non-whites. Preoperative self-isolation, preoperative testing for SARS-CoV-2, and surgery in institutions not concurrently treating COVID-19 patients did not reduce the incidence of postoperative COVID-19. Postoperative symptomatic COVID-19 was more likely if the surgery was performed during a COVID-19 peak in that country., Conclusions: BS can be performed safely during the COVID-19 pandemic with appropriate perioperative protocols. There was no relationship between preoperative testing for COVID-19 and self-isolation with symptomatic postoperative COVID-19. The risk of postoperative COVID-19 risk was greater in non-whites or if BS was performed during a local peak., (© 2021. The Author(s).)

Published
2021
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34. Totally Laparoscopic Transgastric Resection of a Gastric Submucosal Fibrolipoma and Concomitant Sleeve Gastrectomy in a Morbidly Obese Patient.

Author

Pennisi D, Troian M, Nagliati C, and Balani A

Subjects
Gastrectomy, Humans, Stomach, Treatment Outcome, Laparoscopy, Obesity, Morbid surgery
Abstract

Introduction: To evaluate feasibility and safety of a totally laparoscopic transgastric resection with concomitant sleeve gastrectomy in a morbidly obese presenting with benign lesion located along the lesser gastric curvature., Materials and Methods: We report the case of a morbidly obese patient with an incidental submucosal lesion of the lesser curvature radiologically consistent with fibrolipoma at preoperative work-up. Benign nature of the mass was then confirmed EUS-biopsy., Results: A combinated laparoscopic transgastric approach was successfully attempted resulting in a complete excision of the submucosal lesion and concomitant sleeve gastrectomy. Intraoperative and definitive histology confirmed the benign nature of the mass. Postoperative course was uneventful., Conclusion: Concomitant transgastric resection of submucosal benign lesions during laparoscopic sleeve gastrectomy represents both a safe and feasible surgical approach in morbidly obese patients. Preoperative work-up is of great importance in order to assess the benign nature of the lesion.

Published
2020
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35. Enhanced Recovery after Bariatric Surgery: 202 Consecutive Patients in an Italian Bariatric Center.

Author

Nagliati C, Troian M, Pennisi D, and Balani A

Subjects
Adult, Aged, Feasibility Studies, Female, Humans, Italy epidemiology, Length of Stay statistics & numerical data, Male, Middle Aged, Patient Readmission statistics & numerical data, Postoperative Complications epidemiology, Prospective Studies, Young Adult, Bariatric Surgery, Enhanced Recovery After Surgery
Abstract

Background: Enhanced Recovery After Surgery (ERAS) pathways have been shown to improve postoperative outcomes. However, its application in bariatric surgery is still limited. The aim of the study was to define the safety of ERAS in bariatric patients with regard to postoperative complications, length of hospital stay (LOS), and readmission rates within 30 days from surgery., Methods: The effectiveness and safety of an ERAS protocol was prospectively investigated in morbidly obese patients who underwent bariatric surgery in a single-institute experience over a 2-year period., Results: Between June 2016 and September 2018, a total of 89 laparoscopic sleeve gastrectomy (SG), 105 Roux-en-Y gastric bypass (RYGB), and 8 one-anastomosis gastric bypass (OAGB) were performed. Twenty patients (9.9%) were revisional cases. Mean (standard deviation, SD) BMI and age at time of surgery were 43.2 (± 6.2) kg/m 2 and 46 (± 11.3) years, respectively. Median (range) surgical time was 118 (45-255) minutes. Overall postoperative complication rate was 7.4%, with 6 (3.0%) patients developing grade III-IV complications according to the Clavien-Dindo classification. Median (range) LOS was 2 (1-50) days, with mean (SD) LOS of 2.3 (± 3.6) days. Overall, 36.6% of patients were discharged by first postoperative day and 77.7% by second postoperative day. Readmission rate was 4.5%. No mortality was observed during the study period., Conclusions: According to the results of the present study, ERAS in primary and revisional bariatric surgery is safe and feasible, with short LOS, low morbidity and readmission rates, and no mortality. A significant reduction of mean LOS was progressively noted over the study period.

Published
2019
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36. Implementation of the Champions for Skin Integrity model to improve leg and foot ulcer care in the primary healthcare setting.

Author

Parker CN, Shuter P, Maresco-Pennisi D, Sargent J, Collins L, Edwards HE, and Finlayson KJ

Subjects
Australia, Evidence-Based Nursing methods, Foot Ulcer prevention & control, Humans, Inservice Training methods, Primary Care Nursing methods, Primary Health Care standards, Quality Improvement, Surveys and Questionnaires, Foot Ulcer nursing, Health Personnel education, Skin injuries
Abstract

Aims: To facilitate evidence-based leg and foot ulcer management through implementation of the Champions for Skin Integrity model to education in primary health care in Australia., Background: Leg and foot ulcers are frequently seen wounds in general practice and wound care the most frequently performed activity by practice nurses. The literature reports the lack of evidence-based leg and foot ulcer assessment, management and prevention strategies in this setting, and previous research in regard to confidence and knowledge has indicated that general practice health professionals have the greatest need for education in wound care., Design: Pre-post, nonequivalent group research design., Methods: The Champions for Skin Integrity model of evidence-based wound management utilised strategies including workshops, development of Champions and use of resources. Pre- and post-implementation health professional surveys and patient clinical audits were completed. Descriptive statistics were calculated for all variables. Paired t tests identified statistically significant differences between the pre/post staff survey data. STROBE guidelines for reporting were followed (See Appendix S1)., Results: One hundred nine general practice healthcare professional staff attended the workshops. Significant outcomes were noted in increased levels of confidence in ability to assess, manage and prevent all types of leg and foot ulcers, as well as to apply evidence-based practice and change management following workshops. Pre- and post-skin audits also indicated an increase in evidence-based practices., Conclusion: Implementation of Champions for Skin Integrity strategies in this sample of primary healthcare professionals in general practice fostered a positive change in evidence-based wound management, assessment and prevention., Relevance to Clinical Practice: The Champions for Skin Integrity model has supported increases in evidence-based practices in treatment and management of wounds in primary healthcare professionals, similar to the positive outcomes gained in the aged care setting. This is likely to lead to positive outcomes for those with wounds in this setting., (© 2019 John Wiley & Sons Ltd.)

Published
2019
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37. Effectiveness of topical use of Lietofix ® in wound healing after pilonidalis sinus excision: a multicenter study by the Italian Society of Colorectal Surgery (SICCR).

Author

Giannini I, Andreoli R, Bianchi FP, Cavallaro V, Corno F, Geccherle A, Ghiglione F, Legnaro A, Losacco L, Marola S, Orlandi S, Pecorella G, Pennisi D, Perinotti R, Poli F, Pozzo M, Pulzato L, Schembari E, Tafuri S, Tegon G, Tricomi N, Velci L, Vittadello F, and Santoro GA

Subjects
Administration, Topical, Adolescent, Adult, Alginates administration & dosage, Aloe, Colostrum, Female, Glycerol administration & dosage, Humans, Hyaluronic Acid administration & dosage, Italy, Male, Middle Aged, Ointments chemistry, Postoperative Period, Treatment Outcome, Young Adult, Digestive System Surgical Procedures methods, Ointments administration & dosage, Pilonidal Sinus surgery, Wound Healing drug effects
Published
2019
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38. Genome-wide association study in Guillain-Barré syndrome.

Author

Blum S, Ji Y, Pennisi D, Li Z, Leo P, McCombe P, and Brown MA

Subjects
Adolescent, Adult, Aged, Aged, 80 and over, Case-Control Studies, Female, Genetic Predisposition to Disease epidemiology, Guillain-Barre Syndrome epidemiology, Humans, Male, Middle Aged, Young Adult, Genetic Predisposition to Disease genetics, Genome-Wide Association Study methods, Guillain-Barre Syndrome diagnosis, Guillain-Barre Syndrome genetics, Polymorphism, Single Nucleotide genetics
Abstract

Guillain-Barré syndrome (GBS) is considered to have an immune-mediated basis, but the genetic contribution to GBS is unclear. We conducted a GWAS involving 215 GBS patients and 1,105 healthy controls. No significant associations of individual SNPs or imputed HLA types were observed. We performed a genome-wide complex trait analysis for evaluation of the heritability of GBS, and found that common SNPs contribute up to 25% of susceptibility to the disease. Genetic risk score analysis showed no evidence of overlap in genetic susceptibility factors of GBS and multiple sclerosis. Given the unexplained heritability of the trait further larger GWAS are indicated., (Copyright © 2018 Elsevier B.V. All rights reserved.)

Published
2018
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39. Crim1 is required for maintenance of the ocular lens epithelium.

Author

Tam OH, Pennisi D, Wilkinson L, Little MH, Wazin F, Wan VL, and Lovicu FJ

Subjects
Actins metabolism, Animals, Cell Differentiation, Cyclin-Dependent Kinase Inhibitor p57 metabolism, Embryonic Development, Epithelium metabolism, Fluorescent Antibody Technique, Indirect, Lens, Crystalline cytology, Lens, Crystalline metabolism, Membrane Proteins metabolism, Mice, Mice, Inbred C57BL, Mice, Mutant Strains, Mice, Transgenic, Signal Transduction physiology, Transforming Growth Factor beta2 metabolism, beta-Crystallins metabolism, Bone Morphogenetic Protein Receptors physiology, Epithelial Cells metabolism, Gene Expression Regulation, Developmental physiology, Lens, Crystalline embryology
Abstract

The development and growth of the vertebrate ocular lens is dependent on the regulated proliferation of an anterior monolayer of epithelial cells, and their subsequent differentiation into elongate fiber cells. The growth factor rich ocular media that bathes the lens mediates these cellular processes, and their respective intracellular signaling pathways are in turn regulated to ensure that the proper lens architecture is maintained. Recent studies have proposed that Cysteine Rich Motor Neuron 1 (Crim1), a transmembrane protein involved in organogenesis of many tissues, might influence cell adhesion, polarity and proliferation in the lens by regulating integrin-signaling. Here, we characterise the lens and eyes of the Crim1 KST264 mutant mice, and show that the loss of Crim1 function in the ocular tissues results in inappropriate differentiation of the lens epithelium into fiber cells. Furthermore, restoration of Crim1 levels in just the lens tissue of Crim1 KST264 mice is sufficient to ameliorate most of the dysgenesis observed in the mutant animals. Based on our findings, we propose that tight regulation of Crim1 activity is required for maintenance of the lens epithelium, and its depletion leads to ectopic differentiation into fiber cells, dramatically altering lens structure and ultimately leading to microphthalmia and aphakia., (Copyright © 2018 Elsevier Ltd. All rights reserved.)

Published
2018
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40. Distinct Wound Healing and Quality-of-Life Outcomes in Subgroups of Patients With Venous Leg Ulcers With Different Symptom Cluster Experiences.

Author

Finlayson K, Miaskowski C, Alexander K, Liu WH, Aouizerat B, Parker C, Maresco-Pennisi D, and Edwards H

Subjects
Aged, Comorbidity, Depression diagnosis, Depression psychology, Fatigue diagnosis, Fatigue psychology, Female, Humans, Leg, Male, Pain diagnosis, Pain psychology, Prevalence, Risk Factors, Sleep Wake Disorders diagnosis, Sleep Wake Disorders psychology, Symptom Assessment methods, Symptom Assessment statistics & numerical data, Syndrome, Treatment Outcome, Varicose Ulcer diagnosis, Varicose Ulcer psychology, Depression epidemiology, Fatigue epidemiology, Pain epidemiology, Quality of Life psychology, Sleep Wake Disorders epidemiology, Varicose Ulcer epidemiology, Wound Healing
Abstract

Context: Adults with venous leg ulcers frequently experience multiple symptoms that may influence quality of life (QOL)., Objectives: The objective of this study was to identify patient subgroups based on their experience with a pain-depression-fatigue-sleep disturbance symptom cluster and to identify differences in patient characteristics and wound-healing and QOL outcomes between the subgroups., Methods: Secondary data analysis from previous longitudinal studies of 247 patients with venous leg ulcers. Latent class analysis identified subgroups of patients with distinct experiences with the symptom cluster of pain, depression, fatigue, and sleep disturbance. Hierarchical regression analysis identified relationships between the subgroups and QOL outcomes. Survival analysis identified differences between the subgroups and ulcer healing., Results: Latent class analysis found 67% of patients were in a mild symptom subgroup (i.e., experiencing no or mild pain, depressive symptoms, fatigue, or sleep disturbance). One-third of the samples were in a severe symptom subgroup, who reported moderate-to-severe levels of these symptoms. Compared with the mild subgroup, patients in the severe subgroup had poorer QOL scores (t = 8.06, P < 0.001). Symptom subgroup membership accounted for 19% of the variance (P < 0.001) within a hierarchical regression model that explained 42% of the variance in QOL (F(7,170) = 16.89, P < 0.001, R 2  = 0.42). Cox proportional hazards regression found that at enrollment into the study, patients in the severe symptom subgroup were 1.5 times (95% confidence interval 1.02-2.08) less likely to heal in the following 24 weeks (P = 0.037)., Conclusion: Significant relationships were found between delayed ulcer healing, decreased QOL, and membership in the severe symptom subgroup. These findings suggest that comprehensive symptom assessment is needed to identify patients at higher risk for poor outcomes and enable early intervention., (Copyright © 2017 American Academy of Hospice and Palliative Medicine. Published by Elsevier Inc. All rights reserved.)

Published
2017
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41. Practice nurse involvement in the management of adults with type 2 diabetes mellitus attending a general practice: results from a systematic review.

Author

Parker D, Maresco-Pennisi D, Clifton K, Shams R, and Young J

Subjects
Adult, Diabetes Mellitus, Type 2 complications, Diabetes Mellitus, Type 2 drug therapy, General Practice organization & administration, Humans, Hypercholesterolemia drug therapy, Hypertension drug therapy, Nurse's Role, Treatment Outcome, Diabetes Mellitus, Type 2 nursing, Nurses
Abstract

Aim: Using the methodology of the Joanna Briggs Institute, a systematic review of current research was performed to determine if the addition of management by nurses had been more effective in improving clinical outcomes of patients with type 2 diabetes attending a general practice compared with standard care., Methods: A three-step literature search was conducted for suitable English studies with quantitative clinical outcomes that had been published from January 1990 to May 2014. Randomised controlled trials (RCTs) were particularly sought after; however, other research designs were considered. Articles were assessed by two independent reviewers for methodological validity, prior to inclusion in the review, using standardised critical appraisal instruments from the Joanna Briggs Institute. When possible, quantitative data were pooled in statistical meta-analysis., Results: Seven studies were of suitable quality and relevance for the review: these included three randomised control trials; two cluster- RCTs; a cluster, nonrandomised, controlled before-after study; and a cluster observational cohort study. These studies yield evidence that nurse management in addition to standard general practitioner care leads to modest improvements in blood pressure and total cholesterol levels in adults with type 2 diabetes attending a general practice., Conclusion: Meta-analysis identified modest, significant improvements amongst participants in nurse management interventions (NMIs) in the following clinical outcomes: mean SBP, mean DBP and mean total cholesterol. The majority of outcomes studied did not show any advantage to adding NMIs to general practitioner care. Two studies reported significant improvements of participants with poor control in mean haemoglobin A1c. An RCT that investigates the effect of NMIs on patients, with poor control in regard to clinical outcomes and cost effectiveness, is recommended.

Published
2016
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42. Crim1 has an essential role in glycogen trophoblast cell and sinusoidal-trophoblast giant cell development in the placenta.

Author

Pennisi DJ, Kinna G, Chiu HS, Simmons DG, Wilkinson L, and Little MH

Subjects
Animals, Bone Morphogenetic Protein Receptors genetics, Bone Morphogenetic Protein Receptors metabolism, Cell Differentiation genetics, Cell Differentiation physiology, Embryo, Mammalian, Female, Gene Expression Regulation, Developmental, Giant Cells cytology, Giant Cells metabolism, Mice, Mice, Inbred C57BL, Mice, Transgenic, Placenta embryology, Placenta metabolism, Placentation physiology, Pregnancy, Trophoblasts metabolism, Bone Morphogenetic Protein Receptors physiology, Giant Cells physiology, Glycogen metabolism, Placenta cytology, Placentation genetics, Trophoblasts physiology
Abstract

Normal placental development and function is essential for fetal growth of eutherian mammals. Mutational studies have shown that numerous growth factors are required for placental development and differentiation of placental lineages. Here, using a gene-trap mutant mouse line, Crim1(KST264), we show that Crim1 is essential for murine placental development. Crim1 is a developmentally expressed, trans-membrane regulator of growth factor activity. Crim1(KST264/KST264) mutant placentae displayed hypoplasia from 13.5 dpc, and altered structure from 15.5 dpc, including alterations in cell number in both the junctional and labyrinth zones. Using the reporter gene from the Crim1(KST264) allele, we found that Crim1 is expressed in multiple cell types of the placenta, including strong expression in the spongiotrophoblast cells of the junctional zone. In the junctional zone of Crim1(KST264/KST264) placentae, there was an increase in the glycogen trophoblast cells adjacent to the spongiotrophoblast cells. In the labyrinth zone, we found a decrease in the density of sinusoidal-trophoblast giant cells. Our findings show that Crim1 is required for placental development, and is necessary for the proper differentiation of sinusoidal-trophoblast giant cells and glycogen trophoblast cells., (Copyright © 2011 Elsevier Ltd. All rights reserved.)

Published
2012
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43. Kidney development: two tales of tubulogenesis.

Author

Little M, Georgas K, Pennisi D, and Wilkinson L

Subjects
Animals, Gene Expression Regulation, Developmental, Glial Cell Line-Derived Neurotrophic Factor genetics, Glial Cell Line-Derived Neurotrophic Factor metabolism, Humans, Kidney anatomy & histology, Kidney growth & development, Kidney Diseases pathology, Kidney Diseases physiopathology, Kidney Tubules anatomy & histology, Kidney Tubules embryology, Kidney Tubules growth & development, Proto-Oncogene Proteins c-ret genetics, Proto-Oncogene Proteins c-ret metabolism, Signal Transduction physiology, Stem Cells cytology, Stem Cells physiology, Wnt Proteins genetics, Wnt Proteins metabolism, Kidney embryology, Morphogenesis physiology, Organogenesis physiology
Abstract

The mammalian kidney may well be one of the most complex organs of postnatal life. Each adult human kidney contains on average more than one million functional filtration units, the nephrons, residing within a specialized cellular interstitium. Each kidney also contains over 25 distinct cell types, each of which must be specifically aligned with respect to each other to ensure both normal development and ultimately, normal renal function. Despite this complexity, the development of the kidney can be simplistically described as the coordinate formation of two distinct sets of tubules. These tubules develop cooperatively with each other in time and space, yet represent two distinct but classical types of tubulogenesis. The first of these tubules, the ureteric bud, forms as an outgrowth of another epithelial tube, the nephric duct, and undergoes extensive branching morphogenesis to create the collecting system of the kidney. The second tubules are the nephrons themselves which arise via a mesenchyme-to-epithelial transition induced by the first set of tubules. These tubules never branch, but must elongate to become intricately patterned and functionally segmented tubules. The molecular drivers for these two tales of tubulogenesis include many gene families regulating tubulogenesis and branching morphogenesis in other organs; however, the individual players and codependent interrelationships between a branched and non-branched tubular network make organogenesis in the kidney unique. Here we review both what is known and remains to be understood in kidney tubulogenesis., (Copyright 2010 Elsevier Inc. All rights reserved.)

Published
2010
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44. Barriers to the best care of the dying in Queensland, Australia.

Author

Hardy J, Maresco-Pennisi D, Gilshenan K, and Yates P

Subjects
Australia epidemiology, Catchment Area, Health, Culture, Fear, Health Services Needs and Demand, Humans, Palliative Care standards, Attitude to Death, Palliative Care statistics & numerical data
Abstract

The process of dying for many Australians is not ideal. To improve the care of the dying in our community, the barriers preventing optimal care must be identified. Forty-two important barriers were identified by focus groups. Health care professionals (HCPs) working in palliative care (PC) throughout Queensland were asked to rate the importance of each of the barriers. Inadequate funding for PC, lack of after-hours care, insufficient medical support and the lack of HCPs in PC across several different settings were highlighted as the most important barriers. Uncertainty regarding death certification, society's difficulty in responding to cultural needs, patient fears that active treatment would be stopped and fear of palliative care were considered the least important barriers. Many HCPs seem concerned about issues they are less likely to influence. The results of this survey may be useful for future workforce planning.

Published
2008
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45. Crim1KST264/KST264 mice implicate Crim1 in the regulation of vascular endothelial growth factor-A activity during glomerular vascular development.

Author

Wilkinson L, Gilbert T, Kinna G, Ruta LA, Pennisi D, Kett M, and Little MH

Subjects
Age Factors, Albuminuria physiopathology, Animals, Animals, Outbred Strains, COS Cells, Capillaries embryology, Capillaries metabolism, Chlorocebus aethiops, Cystine metabolism, Endothelial Cells metabolism, Endothelial Cells ultrastructure, Female, Gene Expression Regulation, Developmental physiology, Glomerular Filtration Rate, Kidney Glomerulus ultrastructure, Male, Mesangial Cells metabolism, Mesangial Cells ultrastructure, Mice, Mice, Inbred C57BL, Mice, Mutant Strains, Microscopy, Immunoelectron, Podocytes metabolism, Podocytes ultrastructure, Signal Transduction physiology, Transforming Growth Factor beta metabolism, Vascular Endothelial Growth Factor Receptor-2 metabolism, Albuminuria metabolism, Bone Morphogenetic Protein Receptors genetics, Bone Morphogenetic Protein Receptors metabolism, Kidney Glomerulus blood supply, Kidney Glomerulus embryology, Vascular Endothelial Growth Factor A metabolism
Abstract

Crim1, a transmembrane cysteine-rich repeat-containing protein that is related to chordin, plays a role in the tethering of growth factors at the cell surface. Crim1 is expressed in the developing kidney; in parietal cells, podocytes, and mesangial cells of the glomerulus; and in pericytes that surround the arterial vasculature. A gene-trap mouse line with an insertion in the Crim1 gene (Crim1(KST264/KST264)) displayed perinatal lethality with defects in multiple organ systems. This study further analyzed the defects that are present within the kidneys of these mice. Crim1(KST264/KST264) mice displayed abnormal glomerular development, illustrated by enlarged capillary loops, podocyte effacement, and mesangiolysis. When outbred, homozygotes that reached birth displayed podocyte and glomerular endothelial cell defects and marked albuminuria. The podocytic co-expression of Crim1 with vascular endothelial growth factor-A (VEGF-A) suggested a role for Crim1 in the regulation of VEGF-A action. Crim1 and VEGF-A were shown to interact directly, providing evidence that cysteine-rich repeat-containing proteins can bind to non-TGF-beta superfamily ligands. Crim1(KST264/KST264) mice display a mislocalization of VEGF-A within the developing glomerulus, as assessed by immunogold electron microscopy and increased activation of VEGF receptor 2 (Flk1) in the glomerular endothelial cells, suggesting that Crim1 regulates the delivery of VEGF-A by the podocytes to the endothelial cells. This is the first in vivo demonstration of regulation of VEGF-A delivery and supports the hypothesis that Crim1 functions to regulate the release of growth factors from the cell of synthesis.

Published
2007
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46. A role for Tbx5 in proepicardial cell migration during cardiogenesis.

Author

Hatcher CJ, Diman NY, Kim MS, Pennisi D, Song Y, Goldstein MM, Mikawa T, and Basson CT

Subjects
Animals, Cell Differentiation physiology, Cell Division genetics, Cell Line, Tumor, Chick Embryo, Coronary Vessels embryology, Coronary Vessels metabolism, Dogs, Gene Dosage, Gestational Age, Humans, Myocardium chemistry, Myocardium metabolism, Osteosarcoma metabolism, Osteosarcoma pathology, Osteosarcoma virology, Pericardium cytology, Pericardium metabolism, Retroviridae genetics, T-Box Domain Proteins biosynthesis, T-Box Domain Proteins genetics, Transcription Factors genetics, Transfection, Zebrafish Proteins genetics, Cell Movement physiology, Heart embryology, Pericardium embryology, T-Box Domain Proteins physiology
Abstract

Transcriptional regulatory cascades during epicardial and coronary vascular development from proepicardial progenitor cells remain to be defined. We have used immunohistochemistry of human embryonic tissues to demonstrate that the TBX5 transcription factor is expressed not only in the myocardium, but also throughout the embryonic epicardium and coronary vasculature. TBX5 is not expressed in other human fetal vascular beds. Furthermore, immunohistochemical analyses of human embryonic tissues reveals that unlike their epicardial counterparts, delaminating epicardial-derived cells do not express TBX5 as they migrate through the subepicardium before undergoing epithelial-mesenchymal transformation required for coronary vasculogenesis. In the chick, Tbx5 is expressed in the embryonic proepicardial organ (PEO), which is composed of the epicardial and coronary vascular progenitor cells. Retrovirus-mediated overexpression of human TBX5 inhibits cell incorporation of infected proepicardial cells into the nascent chick epicardium and coronary vasculature. TBX5 overexpression as well as antisense-mediated knockdown of chick Tbx5 produce a cell-autonomous defect in the PEO that prevents proepicardial cell migration. Thus, both increasing and decreasing Tbx5 dosage impairs development of the proepicardium. Culture of explanted PEOs demonstrates that untreated chick proepicardial cells downregulate Tbx5 expression during cell migration. Therefore, we propose that Tbx5 participates in regulation of proepicardial cell migration, a critical event in the establishment of the epicardium and coronary vasculature.

Published
2004
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47. Cloning and functional analysis of the Sry-related HMG box gene, Sox18.

Author

Hosking BM, Wyeth JR, Pennisi DJ, Wang SC, Koopman P, and Muscat GE

Subjects
Amino Acid Sequence, Animals, Base Sequence, Cloning, Molecular, Gene Expression Regulation, Heart physiology, Humans, Intestines physiology, Introns, Lung physiology, Mice, Molecular Sequence Data, Muscle, Skeletal physiology, Mutagenesis, Reverse Transcriptase Polymerase Chain Reaction, SOXF Transcription Factors, Sequence Homology, Amino Acid, High Mobility Group Proteins genetics, High Mobility Group Proteins metabolism, Transcription Factors genetics, Transcription Factors metabolism
Abstract

The Sox gene family (Sry like HMG box gene) is characterised by a conserved DNA sequence encoding a domain of approximately 80 amino acids which is responsible for sequence specific DNA binding. We initially published the identification and partial cDNA sequence of murine Sox18, a new member of this gene family, isolated from a cardiac cDNA library. This sequence allowed us to classify Sox18 into the F sub-group of Sox proteins, along with Sox7 and Sox17. Recently, we demonstrated that mutations in the Sox18 activation domain underlie cardiovascular and hair follicle defects in the mouse mutation, ragged (Ra) (Pennisi et al., 2000. Mutations in Sox18 underlie cardiovascular and hair follicle defecs in ragged mice. Nat. Genet. 24, 434-437). Ra homozygotes lack vibrissae and coat hairs, have generalised oedema and an accumulation of chyle in the peritoneum. Here we have investigated the genomic sequences encoding Sox18. Screening of a mouse genomic phage library identified four overlapping clones, we sequenced a 3.25 kb XbaI fragment that defined the entire coding region and approximately 1.5 kb of 5' flanking sequences. This identified (i) an additional 91 amino acids upstream of the previously designated methionine start codon in the original cDNA, and (ii) an intron encoded within the HMG box/DNA binding domain in exactly the same position as that found in the Sox5, -13 and -17 genes. The Sox18 gene encodes a protein of 468 aa. We present evidence that suggests HAF-2, the human HMG-box activating factor -2 protein, is the orthologue of murine Sox18. HAF-2 has been implicated in the regulation of the Human IgH enhancer in a B cell context. Random mutagenesis coupled with GAL4 hybrid analysis in the activation domain between amino acids 252 and 346, of Sox18, implicated the phosphorylation motif, SARS, and the region between amino acid residues 313 and 346 as critical components of Sox18 mediated transactivation. Finally, we examined the expression of Sox18 in multiple adult mouse tissues using RT-PCR. Low-moderate expression was observed in spleen, stomach, kidney, intestine, skeletal muscle and heart. Very abundant expression was detected in lung tissue.

Published
2001
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48. Structure, mapping, and expression of human SOX18.

Author

Pennisi DJ, James KM, Hosking B, Muscat GE, and Koopman P

Subjects
Amino Acid Sequence, Animals, Base Sequence, Chromosome Mapping, DNA Primers, Female, High Mobility Group Proteins chemistry, Humans, Hybrid Cells radiation effects, Male, Mice, Molecular Sequence Data, SOXF Transcription Factors, Sequence Homology, Amino Acid, Transcription Factors chemistry, High Mobility Group Proteins genetics, Transcription Factors genetics
Published
2000
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49. Mutations in Sox18 underlie cardiovascular and hair follicle defects in ragged mice.

Author

Pennisi D, Gardner J, Chambers D, Hosking B, Peters J, Muscat G, Abbott C, and Koopman P

Subjects
Alleles, Animals, Cardiovascular Abnormalities pathology, DNA Mutational Analysis, Endothelium, Vascular cytology, Endothelium, Vascular metabolism, Gene Expression Regulation, Developmental, Genetic Linkage, Hair Follicle metabolism, Hair Follicle pathology, High Mobility Group Proteins biosynthesis, In Situ Hybridization, Inbreeding, Mice, Mice, Mutant Strains, Neovascularization, Physiologic genetics, Phenotype, RNA, Messenger biosynthesis, Receptor Protein-Tyrosine Kinases biosynthesis, Receptor Protein-Tyrosine Kinases deficiency, Receptor Protein-Tyrosine Kinases genetics, Receptors, Growth Factor biosynthesis, Receptors, Growth Factor deficiency, Receptors, Growth Factor genetics, Receptors, Vascular Endothelial Growth Factor, Recombination, Genetic, SOXF Transcription Factors, Transcription Factors biosynthesis, Transcriptional Activation, Cardiovascular Abnormalities genetics, Hair Follicle abnormalities, High Mobility Group Proteins genetics, Point Mutation genetics, Transcription Factors genetics
Abstract

Analysis of classical mouse mutations has been useful in the identification and study of many genes. We previously mapped Sox18, encoding an SRY-related transcription factor, to distal mouse chromosome 2. This region contains a known mouse mutation, ragged (Ra), that affects the coat and vasculature. Here we have directly evaluated Sox18 as a candidate for Ra. We found that Sox18 is expressed in the developing vascular endothelium and hair follicles in mouse embryos. Furthermore, we found no recombination between Sox18 and Ra in an interspecific backcross segregating for the Ra phenotype. We found point mutations in Sox18 in two different Ra alleles that result in missense translation and premature truncation of the encoded protein. Fusion proteins containing these mutations lack the ability to activate transcription relative to wild-type controls in an in vitro assay. Our observations implicate mutations in Sox18 as the underlying cause of the Ra phenotype, and identify Sox18 as a critical gene for cardiovascular and hair follicle formation.

Published
2000
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50. The UTX gene escapes X inactivation in mice and humans.

Author

Greenfield A, Carrel L, Pennisi D, Philippe C, Quaderi N, Siggers P, Steiner K, Tam PP, Monaco AP, Willard HF, and Koopman P

Subjects
Amino Acid Sequence, Animals, Blotting, Northern, Blotting, Southern, Female, Histone Demethylases, Humans, Male, Mice, Molecular Sequence Data, Polymerase Chain Reaction, Transcription, Genetic, Dosage Compensation, Genetic, Nuclear Proteins, Proteins genetics, Proteins metabolism
Abstract

We recently have identified a ubiquitously transcribed mouse Y chromosome gene, Uty , which encodes a tetratricopeptide repeat (TPR) protein. A peptide derived from the UTY protein confers H-Y antigenicity on male cells. Here we report the characterization of a widely transcribed X-linked homologue of Uty , called Utx , which maps to the proximal region of the mouse X chromosome and which detects a human X-linked homologue at Xp11.2. Given that Uty is ubiquitously transcribed, we assayed for Utx expression from the inactive X chromosome (Xi) in mice and found that Utx escapes X chromosome inactivation. Only Smcx and the pseudoautosomal Sts gene on the mouse X chromosome have been reported previously to escape inactivation. The human UTX gene was also found to be expressed from Xi. We discuss the significance of these data for our understanding of dosage compensation of X-Y homologous genes in humans and mice.

Published
1998
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