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Genome-wide association study in Guillain-Barré syndrome.
- Source :
-
Journal of neuroimmunology [J Neuroimmunol] 2018 Oct 15; Vol. 323, pp. 109-114. Date of Electronic Publication: 2018 Aug 02. - Publication Year :
- 2018
-
Abstract
- Guillain-Barré syndrome (GBS) is considered to have an immune-mediated basis, but the genetic contribution to GBS is unclear. We conducted a GWAS involving 215 GBS patients and 1,105 healthy controls. No significant associations of individual SNPs or imputed HLA types were observed. We performed a genome-wide complex trait analysis for evaluation of the heritability of GBS, and found that common SNPs contribute up to 25% of susceptibility to the disease. Genetic risk score analysis showed no evidence of overlap in genetic susceptibility factors of GBS and multiple sclerosis. Given the unexplained heritability of the trait further larger GWAS are indicated.<br /> (Copyright © 2018 Elsevier B.V. All rights reserved.)
- Subjects :
- Adolescent
Adult
Aged
Aged, 80 and over
Case-Control Studies
Female
Genetic Predisposition to Disease epidemiology
Guillain-Barre Syndrome epidemiology
Humans
Male
Middle Aged
Young Adult
Genetic Predisposition to Disease genetics
Genome-Wide Association Study methods
Guillain-Barre Syndrome diagnosis
Guillain-Barre Syndrome genetics
Polymorphism, Single Nucleotide genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1872-8421
- Volume :
- 323
- Database :
- MEDLINE
- Journal :
- Journal of neuroimmunology
- Publication Type :
- Academic Journal
- Accession number :
- 30196823
- Full Text :
- https://doi.org/10.1016/j.jneuroim.2018.07.016