1. Effects of an Orally Administered Prostaglandin Analogue (16,16-Dimethyl Prostaglandin E2) on Human Gastric Secretion
- Author
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Pearl Tao, Gerald Winnan, Donald E. Wilson, and John Quertermus
- Subjects
Adult ,Male ,Peptic Ulcer ,Dose ,medicine.drug_class ,Administration, Oral ,Stimulation ,Pharmacology ,Placebo ,chemistry.chemical_compound ,Pepsin ,medicine ,Humans ,Secretion ,Prostaglandin E2 ,Gastric Juice ,Hepatology ,biology ,Chemistry ,Prostaglandins E ,Gastroenterology ,Depression, Chemical ,biology.protein ,Prostaglandin analogue ,Secretory Rate ,Histamine ,medicine.drug - Abstract
The secretory response to 16, 16-dimethyl prostaglandin E2 (DMPG) administered orally in 4 different dosages and to placebo was evaluated in healthy volunteers over a 2-hr period. During stimulation of gastric secretion by histamine, DMPG at the highest dosage (1.5 mug per kg) reduced volume by 47% and acid output by 79%. Pepsin concentration was not affected. At the same dose, DMPG inhibited basal secretion by 54% and 99% for volume and acid output, respectively. There were no side effects secondary to DMPG administration, which indicates that this compound may be useful in treating peptic ulcer disease.
- Published
- 1975