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The effects of a prostaglandin endoperoxide analogue on canine gastric acid and mucus secretion
- Source :
- Digestive Diseases and Sciences. 24:449-454
- Publication Year :
- 1979
- Publisher :
- Springer Science and Business Media LLC, 1979.
-
Abstract
- The effects of U-46619, a stable analogue of the prostaglandin endoperoxide PGH2, were studied on canine gastric acid secretion, gastric mucosal blood flow, and secretion of mucus into gastric juice and compared to those of PGE2. U-46619 was approximately four and three times as potent as PGE2 in inhibiting acid secretion and stimulating mucus secretion, respectively. When infused at a low dose, U-46619 inhibited acid secretion directly without causing a decrease in the ratio of mucosal blood flow to volume rate of secretion (R), this effect being similar to that observed for PGE2. However, unlike PGE2, U-46619 when administered in a higher dose caused a decline in R while decreasing acid secretion and mucosal blood flow, suggesting a primary restriction of blood flow. The antisecretory effects of arachidonic acid may be due in part to the endogenous formation of prostaglandin endoperoxides as opposed solely to prostaglandin formation. Considering the antisecretory and mucogenic actions of U-46619, nontoxic analogues of prostaglandin endoperoxides may be of value as antiulcer agents.
- Subjects :
- medicine.medical_specialty
Physiology
Endogeny
Arachidonic Acids
Biology
chemistry.chemical_compound
Dogs
Internal medicine
medicine
Animals
Prostaglandins H
Infusions, Parenteral
Secretion
Aminopyrine
Prostaglandin endoperoxide
Gastric Juice
Prostaglandins E
Gastroenterology
Blood flow
Gastric mucosal blood flow
Mucus
Prostaglandin Endoperoxides, Synthetic
Endocrinology
chemistry
Gastric Mucosa
Regional Blood Flow
Sialic Acids
Gastric acid
Female
lipids (amino acids, peptides, and proteins)
Arachidonic acid
Subjects
Details
- ISSN :
- 15732568 and 01632116
- Volume :
- 24
- Database :
- OpenAIRE
- Journal :
- Digestive Diseases and Sciences
- Accession number :
- edsair.doi.dedup.....69b893459e3e7d8f0ae5da43f4f03687