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5. Gamificación como Técnica de Aprendizaje en la Estimulación de las Inteligencias Múltiples en el Nivel de Inicial II

Author

Recalde Drouet, Elizabeth Magdalena, Arias Pintado, Jenny Alexandra, Uzhca Salto, Lucia, Pérez Heras, Rosa Hortencia, Recalde Drouet, Elizabeth Magdalena, Arias Pintado, Jenny Alexandra, Uzhca Salto, Lucia, and Pérez Heras, Rosa Hortencia

Abstract

The general objective of this article is to study gamification as a learning technique in the stimulation of multiple intelligences in children at the Pre-school II level. The study methodology was of the documentary and field type, with a mixed approach since it handled both horizons: qualitative and quantitative. The techniques used were: the interview, conducted with two specialists; and the survey, applied to a sample of 55 teachers. As results, it was obtained that the teachers of the educational institutions of the Zone 2 Learning Network, District 17D11 perceive gamification as a technique that benefits the learning process, however, not all of them integrate it into their planning. On the other hand, the most used tool is PowerPoint because they do not always have access to the Internet, and most of the teachers indicate that they do not receive training for the creation and elaboration of gamified activities. So, if we want to obtain a greater potential and stimulation from children, we must put into practice all the possible skills and abilities, and for this we recommend the efficient application of gamification, which will ensure effective learning., El objetivo general del presente artículo es estudiar la gamificación como técnica de aprendizaje en la estimulación de las inteligencias múltiples en niños y niñas del nivel de Inicial II. La metodología de estudio fue de tipo documental y de campo, con un enfoque mixto ya que manejó ambos horizontes: cualitativo y cuantitativo. Las técnicas utilizadas fueron: la entrevista, realizada a dos especialistas; y la encuesta, aplicada a una muestra de 55 docentes. Como resultados, se obtuvo que los docentes de las instituciones educativas de la Red de aprendizaje de la Zona 2, Distrito 17D11 perciben a la gamificación como una técnica que beneficia el proceso de aprendizaje, sin embargo, no todos la integran dentro de sus planificaciones. Por otra parte, la herramienta más usada es el PowerPoint debido a que no siempre tienen acceso a internet, igualmente la mayoría de los docentes indican que no reciben capacitación para la creación y elaboración de actividades gamificadas. De manera que si se desea obtener un mayor potencial y estimulación de parte de los niños, se deben poner en práctica todas la habilidades y destrezas posibles, y para ello se recomienda la aplicación eficiente de la gamificación, el cual garantizará un aprendizaje eficaz.

Published
2024

8. Neutropenia febril posquimioterapia. Estancia hospitalaria y experiencia en nuestro medio

Author

Íñigo Pérez-Heras, Roberto Carlos Raynero-Mellado, Raquel Díaz-Merchán, and Nerea Domínguez-Pinilla

Subjects
Chemotherapy-induced febrile neutropenia, Length of stay, Neoplasms, Child, Pediatrics, RJ1-570
Abstract

Resumen: Introducción: Las infecciones son una causa importante de morbimortalidad en los pacientes con cáncer (mortalidad estimada en 3%). La neutropenia febril conlleva con frecuencia el ingreso hospitalario de los pacientes oncológicos, incrementando el riesgo de infección nosocomial así como los costes sanitarios por ingresos. Métodos: Estudio observacional ambispectivo (01/07/2015 - 31/12/2018) de los episodios de neutropenia febril posquimioterapia en población pediátrica. Se recogieron edad, sexo, percentil de peso (OMS), estancia hospitalaria (días), temperature (oC), aislamiento de germen, foco infeccioso, profilaxis o no antibiótica y antifúngica, cifras de hemoglobina (g/dl), plaquetas (/mm3), neutrófilos (/mm3), linfocitos (/mm3), monocitos (/mm3), proteína C reactiva (PCR) (mg/L) y procalcitonina (PCT) (ng/ml) al ingreso y días con neutropenia 90 mg/L (10,94 vs. 6,66 días p 0,017), si PCT> 1ng/ml (16,50 vs. 6,77 días p 0,0002), si ≤100 neutrófilos (8,27 vs. 5,04 días p 0,039) y si hubo aislamiento microbiológico (9,54 vs. 5,78 días p 0,006). Conclusión: La relación entre hemoglobina, plaquetas y linfocitos al ingreso con la estancia media es inversamente proporcional. Además, aquellos pacientes con ≤100 neutrófilos al ingreso, PCR >90 mg/L y PCT >1ng/ml presentaron mayor estancia media. Estos factores podrían ser importantes en el manejo de la neutropenia febril en el paciente con cáncer infantil. Abstract: Introduction: Infections are significant cause of morbidity and mortality in cancer patients (mortality is estimated at around 3%). Febrile neutropenia often leads to the hospitalisation of cancer patients, increasing the risk of nosocomial infection, as well as health costs due to the hospital admission. Methods: An ambispective (01 July 2015 – 12 July 2018) observational study was conducted on all episodes of chemotherapy-induced febrile neutropenia in a paediatric population. A record was made of age, gender, weight percentile (WHO), length of hospital stay (days), temperature (oC), microbial isolation, infectious source, antibiotic or antifungal prophylaxis, haemoglobin (g/dl), platelets (/mm3), neutrophils (/mm3), lymphocytes (/mm3), monocytes (/mm3), CRP (mg/L) and procalcitonin (PCT) (ng/ml) on admission, and days with neutropenia90 mg/L (10.94 vs. 6.66 days, P = .017), if PCT >1ng/ml (16.50 vs. 6.77 days, P = .0002), if ≤ 100 neutrophils (8.27 vs. 5.04 days P = .039) on admission, and if there was microbe isolation (9.54 vs. 5.78 days P = .006). Conclusion: The relationship between haemoglobin, platelets, and lymphocytes on admission and the mean stay is inversely proportional. In addition, those patients with ≤100 neutrophils, CRP >90 mg/L, and PCT >1ng/ml on admission had a longer hospital stay.

Published
2020
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9. Post chemotherapy febrile neutropenia. Length of stay and experience in our population

Author

Íñigo Pérez-Heras, Roberto Carlos Raynero-Mellado, Raquel Díaz-Merchán, and Nerea Domínguez-Pinilla

Subjects
Neutropenia febril, Quimioterapia, Estancia media, Neoplasia, Niño, Pediatrics, RJ1-570
Abstract

Introduction: Infections are a significant cause of morbidity and mortality in cancer patients (mortality is estimated at around 3%). Febrile neutropenia often leads to the hospitalisation of cancer patients, increasing the risk of nosocomial infection, as well as health costs due to the hospital admission. Methods: An ambispective (01 July 2015–12 July 2018) observational study was conducted on all episodes of chemotherapy-induced febrile neutropenia in a paediatric population. A record was made of age, gender, weight percentile (WHO), length of hospital stay (days), temperature (°C), microbial isolation, infectious source, antibiotic or antifungal prophylaxis, haemoglobin (g/dl), platelets (/mm3), neutrophils (/mm3), lymphocytes (/mm3), monocytes (/mm3), CRP (mg/L) and procalcitonin (PCT) (ng/ml) on admission, and days with neutropenia 90 mg/L (10.94 vs. 6.66 days, P = .017), if PCT > 1 ng/ml (16.50 vs. 6.77 days, P = .0002), if ≤100 neutrophils (8.27 vs. 5.04 days P = .039) on admission, and if there was microbe isolation (9.54 vs. 5.78 days P = .006) Conclusion: The relationship between haemoglobin, platelets, and lymphocytes on admission and the mean stay is inversely proportional. In addition, those patients with ≤100 neutrophils, CRP > 90 mg/L, and PCT > 1 ng/ml on admission had a longer hospital stay. Resumen: Introducción: Las infecciones son una causa importante de morbimortalidad en los pacientes con cáncer (mortalidad estimada en 3%). La neutropenia febril conlleva con frecuencia el ingreso hospitalario de los pacientes oncológicos, incrementando el riesgo de infección nosocomial así como los costes sanitarios por ingresos. Métodos: Estudio observacional ambispectivo (01/07/2015–31/12/2018) de los episodios de neutropenia febril post-quimioterapia en población pediátrica. Se recogieron edad, sexo, percentil de peso(OMS), estancia hospitalaria(días), temperature (°C), aislamiento de germen, foco infeccioso, profilaxis o no antibiótica y antifúngica, cifras de hemoglobina(g/dl), plaquetas(/mm3), neutrófilos(/mm3), linfocitos(/mm3), monocitos(/mm3), proteína C reactiva (PCR)(mg/L) y procalcitonina(PCT)(ng/ml) al ingreso y días con neutropenia 90 mg/L(10,94 vs.6,66 días p0,017), si PCT > 1 ng/ml (16,50 vs.6,77 días p0,0002), si ≤100neutrófilos(8,27vs.5,04 días p0,039) y si hubo aislamiento microbiológico (9,54vs.5,78 días p0,006). Conclusión: La relación entre hemoglobina, plaquetas y linfocitos al ingreso con la estancia media es inversamente proporcional. Además, aquellos pacientes con ≤100 neutrófilos al ingreso, PCR>90 mg/L y PCT>1 ng/ml presentaron mayor estancia media. Estos factores podrían ser importantes en el manejo de la neutropenia febril en el paciente con cáncer infantil.

Published
2020
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10. Legume consumption is inversely associated with type 2 diabetes incidence in adults: A prospective assessment from the PREDIMED study

Author

Serra-Mir, M., Pérez-Heras, A., Viñas, C., Casas, R., Medina-Renom, A., Baena, J.M., García, M., Oller, M., Amat, J., Duaso, I., García, Y., Iglesias, C., Simón, C., Quinzavos, L., Parra, L., Liroz, M., Benavent, J., Clos, J., Pla, I., Amorós, M., Bonet, M.T., Martín, M.T., Sánchez, M.S., Altirriba, J., Manzano, E., Altés, A., Cofán, M., Valls-Pedret, C., Sala-Vila, A., Doménech, M., Bulló, M., Babio, N., Basora, J., González, R., Molina, C., Márquez, F., Martínez, P., Ibarrola, N., Sorlí, M., García Roselló, J., Castro, A., Martin, F., Tort, N., Isach, A., Guasch-Ferre, M., Cabré, J.J., Mestres, G., Paris, F., Llauradó, M., Pedret, R., Basells, J., Vizcaino, J., Segarra, R., Frigola, J., Costa-Vizcaino, J., Salas-Huetos, A., Boj, J., Montañes, D., Papandreou, Christopher, Fernández-Ballart, J., Carrasco, P., Ortega-Azorín, C., Asensio, E.M., Osma, R., Barragán, R., Francés, F., Guillén, M., González, J.I., Sáiz, C., Portolés, O., Giménez, F.J., Coltell, O., Fernández-Carrión, R., Guillem-Sáiz, P., González-Monje, I., Quiles, L., Pascual, V., Riera, C., Pages, M.A., Godoy, D., Carratalá-Calvo, A., Sánchez-Navarro, S., Valero-Barceló, C., Tello, S., Vila, J., de la Torre, R., Muñoz-Aguayo, D., Elosua, R., Marrugat, J., Schröder, H., Molina, N., Maestre, E., Rovira, A., Castañer, O., Farré, M., Toledo, E., Ruiz-Canela, M., Sanjulián, B., Sánchez-Tainta, A., Eguaras, S., Martí, A., Buil-Cosiales, P., SerranoMartínez, M., Diez-Espino, J., García-Arellano, A., Martínez-Lapiscina, E.H., Goñi, E., Vázquez, Z., Berrade, N., Extremera-Urabayen, V., Arroyo-Azpa, C., García-Pérez, L., Villanueva-Telleria, J., Cortés-Ugalde, F., Sagredo-Arce, T., Vigata-López, M.D., Arceiz Campo, M.T., Urtasun-Samper, A., Gueto Rubio, M.V., Churio-Beraza, B., Arós, F., Salaverria, I., del Hierro, T., Algorta, J., Francisco, S., Alonso-Gómez, A., Sanz, E., Rekondo, J., Belló, M.C., Loma-Osorio, A., Gómez-Gracia, E., Wärnberg, J., Benítez Pont, R., Bianchi Alba, M., Gómez-Huelgas, R., Martínez-González, J., Velasco García, V., de Diego Salas, J., Baca Osorio, A., Gil Zarzosa, J., Sánchez Luque, J.J., Vargas López, E., Ruiz-Gutiérrez, V., Sánchez Perona, J., Montero Romero, E., García-García, M., Jurado-Ruiz, E., Fiol, M., Romaguera, D., García-Valdueza, M., Moñino, M., Munuera, S., Vivó, M., Bestard, F., Munar, J.A., Coll, L., Proenza, A., Prieto, R., Frontera, G., Fiol, F., Ginard, M., Jover, A., García, J., Santos-Lozano, J.M., Ortega-Calvo, M., Mellado, L., García-Corte, F.J., Román, P., Iglesias, P., Corchado, Y., Miró-Moriano, L., Domínguez-Espinaco, C., Lozano-Rodriguez, J.M., Vaquero-Diaz, S., López- Sabater, M.C., Castellote-Bargalló, A.I., Quifer-Rada, P., Tresserra-Rimbau, A., Álvarez-Pérez, J., Díaz-Benítez, E.M., Sánchez-Villegas, A., Casañas-Quintana, L.T., Pérez-Cabrera, J., Ruano-Rodríguez, C., Bautista-Castaño, I., Sarmiento de la Fe, F., García Pastor, J.A., Díaz-González, B.V., Castillo Anzalas, J.M., Sosa-Also, R.E., Medina-Ponce, J., de la Cruz, E., Fanlo-Maresma, M., Galera, A., Trias, F., Sarasa, I., Corbella, E., Corbella, X., Cabezas, C., Vinyoles, E., Rovira, M.A., García, L., Flores, G., Verdú, J.M., Baby, P., Ramos, A., Mengual, L., Roura, P., Yuste, M.C., Guarner, A., Santamaría, M.I., Mata, M., de Juan, C., Brau, A., Tur, J.A., Portillo, M.P., Sáez, G., Aldamiz-Echevarría, M., Alonso-Gómez, A.M., Berjón, J., Forga, L., Gállego, J., García-Layana, A., Larrauri, A., Portu-Zapirain, J., Timiraus-Fernández, J., Becerra-Tomás, Nerea, Díaz-López, Andrés, Rosique-Esteban, Núria, Ros, Emilio, Buil-Cosiales, Pilar, Corella, Dolores, Estruch, Ramon, Fitó, Montserrat, Serra-Majem, Lluís, Arós, Fernando, Lamuela-Raventós, Rosa Maria, Fiol, Miquel, Santos-Lozano, José Manuel, Díez-Espino, Javier, Portoles, Olga, and Salas-Salvadó, Jordi

Published
2018
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14. Post chemotherapy febrile neutropenia. Length of stay and experience in our population

Author

Nerea Domínguez-Pinilla, Roberto Carlos Raynero-Mellado, Raquel Díaz-Merchán, and Íñigo Pérez-Heras

Subjects
medicine.medical_specialty, medicine.drug_class, Population, Antibiotics, Pediatrics, Procalcitonin, RJ1-570, 03 medical and health sciences, 0302 clinical medicine, 030225 pediatrics, Management of Technology and Innovation, Internal medicine, Estancia media, medicine, Inverse correlation, education, education.field_of_study, Neoplasia, business.industry, Neutropenia febril, medicine.disease, El Niño, Niño, Quimioterapia, Post-chemotherapy, business, Febrile neutropenia, Paediatric population
Abstract

Introduction: Infections are a significant cause of morbidity and mortality in cancer patients (mortality is estimated at around 3%). Febrile neutropenia often leads to the hospitalisation of cancer patients, increasing the risk of nosocomial infection, as well as health costs due to the hospital admission. Methods: An ambispective (01 July 2015–12 July 2018) observational study was conducted on all episodes of chemotherapy-induced febrile neutropenia in a paediatric population. A record was made of age, gender, weight percentile (WHO), length of hospital stay (days), temperature (°C), microbial isolation, infectious source, antibiotic or antifungal prophylaxis, haemoglobin (g/dl), platelets (/mm3), neutrophils (/mm3), lymphocytes (/mm3), monocytes (/mm3), CRP (mg/L) and procalcitonin (PCT) (ng/ml) on admission, and days with neutropenia 90 mg/L (10.94 vs. 6.66 days, P = .017), if PCT > 1 ng/ml (16.50 vs. 6.77 days, P = .0002), if ≤100 neutrophils (8.27 vs. 5.04 days P = .039) on admission, and if there was microbe isolation (9.54 vs. 5.78 days P = .006) Conclusion: The relationship between haemoglobin, platelets, and lymphocytes on admission and the mean stay is inversely proportional. In addition, those patients with ≤100 neutrophils, CRP > 90 mg/L, and PCT > 1 ng/ml on admission had a longer hospital stay. Resumen: Introducción: Las infecciones son una causa importante de morbimortalidad en los pacientes con cáncer (mortalidad estimada en 3%). La neutropenia febril conlleva con frecuencia el ingreso hospitalario de los pacientes oncológicos, incrementando el riesgo de infección nosocomial así como los costes sanitarios por ingresos. Métodos: Estudio observacional ambispectivo (01/07/2015–31/12/2018) de los episodios de neutropenia febril post-quimioterapia en población pediátrica. Se recogieron edad, sexo, percentil de peso(OMS), estancia hospitalaria(días), temperature (°C), aislamiento de germen, foco infeccioso, profilaxis o no antibiótica y antifúngica, cifras de hemoglobina(g/dl), plaquetas(/mm3), neutrófilos(/mm3), linfocitos(/mm3), monocitos(/mm3), proteína C reactiva (PCR)(mg/L) y procalcitonina(PCT)(ng/ml) al ingreso y días con neutropenia 90 mg/L(10,94 vs.6,66 días p0,017), si PCT > 1 ng/ml (16,50 vs.6,77 días p0,0002), si ≤100neutrófilos(8,27vs.5,04 días p0,039) y si hubo aislamiento microbiológico (9,54vs.5,78 días p0,006). Conclusión: La relación entre hemoglobina, plaquetas y linfocitos al ingreso con la estancia media es inversamente proporcional. Además, aquellos pacientes con ≤100 neutrófilos al ingreso, PCR>90 mg/L y PCT>1 ng/ml presentaron mayor estancia media. Estos factores podrían ser importantes en el manejo de la neutropenia febril en el paciente con cáncer infantil.

Published
2020

15. Neutropenia febril posquimioterapia. Estancia hospitalaria y experiencia en nuestro medio

Author

Roberto Carlos Raynero-Mellado, Raquel Díaz-Merchán, Íñigo Pérez-Heras, and Nerea Domínguez-Pinilla

Subjects
Chemotherapy-induced febrile neutropenia, 03 medical and health sciences, 0302 clinical medicine, 030225 pediatrics, Neoplasms, Pediatrics, Perinatology and Child Health, Length of stay, Child, Pediatrics, RJ1-570
Abstract

Resumen: Introducción: Las infecciones son una causa importante de morbimortalidad en los pacientes con cáncer (mortalidad estimada en 3%). La neutropenia febril conlleva con frecuencia el ingreso hospitalario de los pacientes oncológicos, incrementando el riesgo de infección nosocomial así como los costes sanitarios por ingresos. Métodos: Estudio observacional ambispectivo (01/07/2015 - 31/12/2018) de los episodios de neutropenia febril posquimioterapia en población pediátrica. Se recogieron edad, sexo, percentil de peso (OMS), estancia hospitalaria (días), temperature (oC), aislamiento de germen, foco infeccioso, profilaxis o no antibiótica y antifúngica, cifras de hemoglobina (g/dl), plaquetas (/mm3), neutrófilos (/mm3), linfocitos (/mm3), monocitos (/mm3), proteína C reactiva (PCR) (mg/L) y procalcitonina (PCT) (ng/ml) al ingreso y días con neutropenia 90 mg/L (10,94 vs. 6,66 días p 0,017), si PCT> 1ng/ml (16,50 vs. 6,77 días p 0,0002), si ≤100 neutrófilos (8,27 vs. 5,04 días p 0,039) y si hubo aislamiento microbiológico (9,54 vs. 5,78 días p 0,006). Conclusión: La relación entre hemoglobina, plaquetas y linfocitos al ingreso con la estancia media es inversamente proporcional. Además, aquellos pacientes con ≤100 neutrófilos al ingreso, PCR >90 mg/L y PCT >1ng/ml presentaron mayor estancia media. Estos factores podrían ser importantes en el manejo de la neutropenia febril en el paciente con cáncer infantil. Abstract: Introduction: Infections are significant cause of morbidity and mortality in cancer patients (mortality is estimated at around 3%). Febrile neutropenia often leads to the hospitalisation of cancer patients, increasing the risk of nosocomial infection, as well as health costs due to the hospital admission. Methods: An ambispective (01 July 2015 – 12 July 2018) observational study was conducted on all episodes of chemotherapy-induced febrile neutropenia in a paediatric population. A record was made of age, gender, weight percentile (WHO), length of hospital stay (days), temperature (oC), microbial isolation, infectious source, antibiotic or antifungal prophylaxis, haemoglobin (g/dl), platelets (/mm3), neutrophils (/mm3), lymphocytes (/mm3), monocytes (/mm3), CRP (mg/L) and procalcitonin (PCT) (ng/ml) on admission, and days with neutropenia90 mg/L (10.94 vs. 6.66 days, P = .017), if PCT >1ng/ml (16.50 vs. 6.77 days, P = .0002), if ≤ 100 neutrophils (8.27 vs. 5.04 days P = .039) on admission, and if there was microbe isolation (9.54 vs. 5.78 days P = .006). Conclusion: The relationship between haemoglobin, platelets, and lymphocytes on admission and the mean stay is inversely proportional. In addition, those patients with ≤100 neutrophils, CRP >90 mg/L, and PCT >1ng/ml on admission had a longer hospital stay.

Published
2020

16. Effect of a 2-year diet intervention with walnuts on cognitive decline. The Walnuts And Healthy Aging (WAHA) study: a randomized controlled trial

Author

Anna López-Illamola, Keiji Oda, Grace J. Lee, Adam Arechiga, Mónica Doménech, Joan Sabaté, Mercè Serra-Mir, David Bartrés-Faz, Nina Coll-Padros, Lídia Vaqué-Alcázar, Montserrat Cofán, Carlos Calvo, Aleix Sala-Vila, Roser Sala-Llonch, Irene Roth, Emilio Ros, Sujatha Rajaram, Dolores Corella, Edward Bitok, Natalie K Buxton, Ana Pérez-Heras, Lynnley Huey, Cinta Valls-Pedret, and Tania M Freitas-Simoes

Subjects
Male, medicine.medical_specialty, Medicine (miscellaneous), Juglans, law.invention, Healthy Aging, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, Memory, law, Internal medicine, Intervention (counseling), medicine, Humans, Nuts, Cognitive Dysfunction, 030212 general & internal medicine, Cognitive decline, Aged, Nutrition and Dietetics, Intention-to-treat analysis, medicine.diagnostic_test, business.industry, Brain, Cognition, Neuropsychological test, Middle Aged, Magnetic Resonance Imaging, Spain, Cohort, Female, business, Neurocognitive, 030217 neurology & neurosurgery
Abstract

Background Walnut consumption counteracts oxidative stress and inflammation, 2 drivers of cognitive decline. Clinical data concerning effects on cognition are lacking. Objectives The Walnuts And Healthy Aging study is a 2-center (Barcelona, Spain; Loma Linda, CA) randomized controlled trial examining the cognitive effects of a 2-y walnut intervention in cognitively healthy elders. Methods We randomly allocated 708 free-living elders (63-79 y, 68% women) to a diet enriched with walnuts at ∼15% energy (30-60 g/d) or a control diet (abstention from walnuts). We administered a comprehensive neurocognitive test battery at baseline and 2 y. Change in the global cognition composite was the primary outcome. We performed repeated structural and functional brain MRI in 108 Barcelona participants. Results A total of 636 participants completed the intervention. Besides differences in nutrient intake, participants from Barcelona smoked more, were less educated, and had lower baseline neuropsychological test scores than those from Loma Linda. Walnuts were well tolerated and compliance was good. Modified intention-to-treat analyses (n = 657) uncovered no between-group differences in the global cognitive composite, with mean changes of -0.072 (95% CI: -0.100, -0.043) in the walnut diet group and -0.086 (95% CI: -0.115, -0.057) in the control diet group (P = 0.491). Post hoc analyses revealed significant differences in the Barcelona cohort, with unadjusted changes of -0.037 (95% CI: -0.077, 0.002) in the walnut group and -0.097 (95% CI: -0.137, -0.057) in controls (P = 0.040). Results of brain fMRI in a subset of Barcelona participants indicated greater functional network recruitment in a working memory task in controls. Conclusions Walnut supplementation for 2 y had no effect on cognition in healthy elders. However, brain fMRI and post hoc analyses by site suggest that walnuts might delay cognitive decline in subgroups at higher risk. These encouraging but inconclusive results warrant further investigation, particularly targeting disadvantaged populations, in whom greatest benefit could be expected.This trial was registered at clinicaltrials.gov as NCT01634841.

Published
2020

17. Influencia terapéutica en la evolución de la otitis media aguda

Author

Eileen Vargas Salamanca, Íñigo Pérez Heras, Manuel Ángel Caro García, and Laura Ruano de Pablo

Subjects
Psychiatry and Mental health, business.industry, Medicine, business
Abstract

Introducción: La otitis media aguda (OMA) es una de las infecciones más comunes y primera causa de administración de antibioterapia en la infancia. En ocasiones pueden tener una evolución tórpida y dar lugar a complicaciones, siendo la mastoiditis aguda la más frecuente. Según algunos estudios se está produciendo un aumento en la incidencia de esta patología y de su gravedad, sin saberse claramente su causa. Métodos: Se realiza un estudio retrospectivo de pacientes ingresados en el Hospital Virgen de la Salud de Toledo, durante un periodo de 64 meses, de 2012 a 2017. Los criterios de inclusión fueron pacientes que fueron diagnosticados de mastoiditis aguda y/o complicaciones derivadas de ésta. Resultados: Se identificaron un total de 22 pacientes con mastoiditis aguda, correspondiendo a una media anual de 4,125 casos/año. El 63,63% de los casos tenían entre 0-2 años. Sólo el 50% de los casos recibieron antibioterapia oral previo al ingreso hospitalario. Se aisló el germen en el 60% de los casos, siendo el S. pneumoniae el causante más frecuente. Se detectaron un total de 4 casos de mastoiditis complicada suponiendo el 18,18% de los pacientes; todos fueron varones, y ninguno tenía supuración espontánea a su llegada a Urgencias. Conclusiones: El uso de antibioterapia oral para el tratamiento de la OMA no ha demostrado que disminuya la incidencia de mastoiditis aguda; sin embargo, es posible que las complicaciones derivadas de una OMA con evolución tórpida sean más graves cuando no se ha empleado antibiótico sistémico para el tratamiento de la OMA.

Published
2020

18. Manejo de un brote de COVID-19 en un despliegue.

Author

I., Pérez-Heras and R., de-Andrés-Palomo

Subjects
*COVID-19 pandemic, *RHINORRHEA, *SYMPTOMS, *ANOSMIA, *ANTIGEN analysis, *VACCINATION, *MEDICAL screening, *WOMEN, *SOCIAL distancing, *COUGH
Abstract

Background and objectives: The COVID-19 pandemic has affected all areas of our society, and international missions are not an exception. With this study we intended to share our experience with an outbreak of COVID-19 in an area of operations. Material and methods: A prospective observational study was performed from 11/23/2021 - 02/22/2022. The variables studied were: sex, age, days since the last vaccine dose, type of vaccine in the first and second doses (Moderna, Pfizer or Astrazeneca), in-theatre deployment with one or two doses, covid-19 prior to deployment, covid-19 during deployment, symptomatology (asymptomatic, anosmia, cough, fever, malaise, headache, runny nose) and volunteering for vaccination in area of operations. Results: A total of 188 (32.1% of the contingent) were positive during the period studied, with 183 close contacts. Of the contingent, 23 (3.9%) were women and 572 (96.1%) men, with a mean age of 32 years. 64.4% were asymptomatic. The symptoms presented were: 10.9% anosmia, 35.9% cough, 9.4% runny nose, 32.8% headache, 57.8% malaise and 20.3% fever. They were all mild cases. Of the positive cases, 90% of those who were vaccinated with a single dose were asymptomatic at diagnosis versus 64% of those vaccinated with two doses (p = 0.01). Conclusions: Our experience with a COVID-19 outbreak during a mission reflects the importance of prevention and control measures for the correct development of the mission. Use of masks is essential, as well as trying to maintain social distancing in the bases. The use of rapid antigen test for diagnosis and screening is a useful and affordable tool. Lax quarantine protocols allow the correct development of the operations without an increase in the risk of infection. [ABSTRACT FROM AUTHOR]

Published
2023
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22. Integration of Hydrogen and Ammonia Energy into Combined Cycles: the FLEXnCONFU Project

Author

Guillén-Ángel, J. and Pérez-Heras, L.

Subjects
Biomass
Abstract

EU is highly dependent on fossil fuels imports, as a way to improve its energetic autonomy, P2X2P solutions could play a key role. This document briefly presents the concept of FLEXnCONFU project, an integration of P2H and P2A solutions into a combined cycle gas turbine (CCGT) plant in Portugal. A consortium of 21 organizations from 10 European countries representing the entire supply chain will collaborate for 4 years on this EU-funded industrial project. The injection of alternative fuels (i.e. H2 and NH3) will help the current “fuel switch” the EU is facing, drastically reducing greenhouse gases (GHG) emissions. P2X solutions, which are currently widely studied, coupled with renewable energy sources (RES), could help the CC to levelling their load reducing its environmental impact., Proceedings of the 29th European Biomass Conference and Exhibition, 26-29 April 2021, Online, pp. 1402-1403

Published
2021
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23. Two Cases of SARS-CoV-2 Infection in Pediatric Oncohematologic Patients in Spain

Author

María Del Pozo-Carlavilla, Verónica Fernandez-Escobar, María Eli Valerio-Alonso, Nerea Domínguez-Pinilla, Raquel Díaz-Merchán, and Íñigo Pérez-Heras

Subjects
Diarrhea, Microbiology (medical), Pediatrics, medicine.medical_specialty, Adolescent, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Pneumonia, Viral, Sarcoma, Ewing, Disease, Wilms Tumor, Lopinavir, Betacoronavirus, 03 medical and health sciences, 0302 clinical medicine, 030225 pediatrics, Pandemic, medicine, Humans, 030212 general & internal medicine, Pediatrics, Perinatology, and Child Health, Respiratory system, Child, Pandemics, Ritonavir, SARS-CoV-2, business.industry, COVID-19, virus diseases, Pediatric cancer, Kidney Neoplasms, Infectious Diseases, Spain, Child, Preschool, Pediatrics, Perinatology and Child Health, Female, medicine.symptom, Coronavirus Infections, business, medicine.drug
Abstract

Since December 2019, severe acute respiratory syndrome coronavirus 2 infection has spread worldwide. We all are concerned about immunocompromised children, especially hematologic and oncologic pediatric patients. We want to share our experience with 2 pediatric cancer patients with severe acute respiratory syndrome coronavirus 2 infection. Both presented mild disease and good outcome. No respiratory symptoms were identified, but both developed diarrhea, one probably secondary to lopinavir/ritonavir. Pediatric cancer patients may have milder disease than adults, but larger studies are needed to make conclusions.

Published
2020
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24. Management of persistent Cryptosporidium spp. infestation in a child with acute myeloid leukemia

Author

Marta García‐Palomo, María Herrera‐López, Íñigo Pérez-Heras, Luis Ignacio Gonzalez-Granado, and Nerea Domínguez-Pinilla

Subjects
Oncology, biology, business.industry, Pediatrics, Perinatology and Child Health, Immunology, Infestation, Medicine, Myeloid leukemia, Cryptosporidium, Hematology, business, biology.organism_classification, medicine.disease_cause
Published
2020

26. Long-chain n-3 PUFA supplied by the usual diet decrease plasma stearoyl-CoA desaturase index in non-hypertriglyceridemic older adults at high vascular risk

Author

Carmen López-Sabater, Dolores Corella, Aleix Sala-Vila, Ana I. Castellote, Montserrat Cofán, Ramon Estruch, Jordi Salas-Salvadó, Mercè Serra-Mir, Miguel-Angel Martínez-González, Ana Pérez-Heras, Jordi Mayneris-Perxachs, Emilio Ros, and Montserrat Fitó

Subjects
Male, medicine.medical_specialty, Mediterranean diet, 030209 endocrinology & metabolism, Context (language use), 030204 cardiovascular system & hematology, Diet, Mediterranean, Critical Care and Intensive Care Medicine, Diet Surveys, Body Mass Index, Cohort Studies, Food group, 03 medical and health sciences, 0302 clinical medicine, Surveys and Questionnaires, Internal medicine, Fatty Acids, Omega-3, medicine, Humans, Food science, Aged, chemistry.chemical_classification, Nutrition and Dietetics, business.industry, Fish oil, Confidence interval, Stearoyl-CoA Desaturase, Endocrinology, chemistry, Hypertension, Lipogenesis, Female, lipids (amino acids, peptides, and proteins), business, Polyunsaturated fatty acid
Abstract

Summary Background & aims The activity of stearoyl-CoA desaturase-1 (SCD1), the central enzyme in the synthesis of monounsaturated fatty acids (MUFA), has been associated with de novo lipogenesis. In experimental models SCD1 is down-regulated by polyunsaturated fatty acids (PUFA), but clinical studies are scarce. The effect of long-chain n-3 PUFA (LCn-3PUFA) supplied by the regular diet, in the absence of fatty fish or fish oil supplementation, remains to be explored. Methods We related 1-y changes in plasma SCD1 index, as assessed by the C16:1n-7/C16:0 ratio, to both adiposity traits and nutrient intake changes in a sub-cohort (n = 243) of non-hypertriglyceridemic subjects of the PREDIMED (PREvencion con DIeta MEDiterranea) trial. Results After adjustment for confounders, including changes in fasting triglycerides, plasma SCD1 index increased in parallel with body weight (0.221 [95% confidence interval, 0.021 to 0.422], P = 0.031) and BMI (0.115 [0.027 to 0.202], P = 0.011). Additionally, dietary LCn-3PUFA (but not MUFA or plant-derived PUFA) were associated with decreased plasma SCD1 index (−0.544 [–1.044 to −0.043], P = 0.033, for each 1 g/ d -increase in LCn-3PUFA). No associations were found for other food groups, but there was a trend for fatty fish intake (−0.083 [–0.177 to 0.012], P = 0.085, for each 10 g/ d -increase). Conclusions Our data add clinical evidence on the down-regulation of plasma SCD1 index by LCn-3PUFA in the context of realistic changes in fish consumption in the customary, non-supplemented diet. Clinical trial registration http://www.Controlled-trials.com/ISRCTN35739639

Published
2018

30. Effect of a 2-year diet intervention with walnuts on cognitive decline. The Walnuts And Healthy Aging (WAHA) study: a randomized controlled trial

Author

Sala-Vila, Aleix, primary, Valls-Pedret, Cinta, additional, Rajaram, Sujatha, additional, Coll-Padrós, Nina, additional, Cofán, Montserrat, additional, Serra-Mir, Mercè, additional, Pérez-Heras, Ana M, additional, Roth, Irene, additional, Freitas-Simoes, Tania M, additional, Doménech, Mónica, additional, Calvo, Carlos, additional, López-Illamola, Anna, additional, Bitok, Edward, additional, Buxton, Natalie K, additional, Huey, Lynnley, additional, Arechiga, Adam, additional, Oda, Keiji, additional, Lee, Grace J, additional, Corella, Dolores, additional, Vaqué-Alcázar, Lídia, additional, Sala-Llonch, Roser, additional, Bartrés-Faz, David, additional, Sabaté, Joan, additional, and Ros, Emilio, additional

Published
2020
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32. [Meconium periorchitis prenatal diagnosis: review of the literature, about 3 cases]

Author

A L, Luque Pérez, R, Martín-Crespo Izquierdo, H, Ramírez Velandia, N, Carrera Guermeur, A, Escobar Izquierdo, I, Pérez Heras, P, Maruszewski, J C, Moreno de Prado, A, Pantoja Bajo, and R, Luque Mialdea

Subjects
Adult, Male, Meconium, Young Adult, Intestinal Perforation, Pregnancy, Infant, Newborn, Humans, Female, Gestational Age, Orchitis, Ultrasonography, Prenatal
Abstract

To assess the importance of prenatal ultrasound diagnosis of the fetus carrying meconium periorchitis and its predictive relevance for fetal monitoring and prognosis in the context of acute fetal intestinal disease.Three male fetuses have been diagnosed of meconium periorchitis in our Unit of Fetal Medicine in the last 5 years. Their prenatal ultrasound diagnoses were: testicular tumor (n=1); Meconium periorchitis with acute fetal intestinal perforation (n=2). Gestational age at diagnosis was 33, 34 and 35 weeks. Ultrasound signs at diagnosis were: Increased size of scrotal zone, with hyperechogenic lesions inside and permanence of peritoneum-vaginal canal; at abdominal zone, echographic signs of intestinal disease with or without meconium peritonitis were found (hyperechogenic lesions, edema of intestinal loops and ascites). All three neonates were assessed postnatally by ultrasound and therapeutic indication.Fetal ultrasound findings influenced both evolution and termination of pregnancy. The diagnosis of meconium periorchitis was confirmed postnatally in all cases: in the 1st case, delivered at term, scrotal tumoral pathology was ruled out and did not require abdominal surgery; the other 2 patients were delivered at the same week of prenatal diagnosis and an inguinal-scrotal surgery with intestinal approach because of meconium peritonitis was performed. No patient underwent orchiectomy, maintaining the teste-epididymal binomial intact.Prenatal ultrasound diagnosis of meconium periorchitis requires a strict ultrasound follow-up of the fetus as it is a specific marker of intestinal perforation, which can lead to the termination of pregnancy and avoid appearance of complicated meconium peritonitis.Evaluar la importancia del diagnóstico ecográfico prenatal del feto portador de periorquitis meconial y su relevancia predictiva del seguimiento y pronóstico fetal en el contexto de una enfermedad intestinal fetal aguda.En los últimos 5 años en la Unidad de Medicina Fetal se han diagnosticado tres fetos varones de periorquitis meconial cuyos diagnósticos ecográficos prenatales fueron: tumor testicular (n=1); y periorquitis meconial con perforación intestinal aguda fetal (n=2). La edad gestacional al diagnóstico fue de 33, 34 y 35 semanas. Los signos ecográficos al diagnóstico fueron: a nivel escrotal, aumento del tamaño, lesiones hiperecogénicas y permanencia del conducto peritoneo-vaginal; a nivel abdominal pueden existir signos ecográficos de enfermedad intestinal con o sin peritonitis meconial (lesiones hiperecogénicas, edemas de asas y ascitis). Los tres neonatos fueron evaluados postnatalmente mediante ecografía comparativa de los hallazgos prenatales e indicación terapéutica.Los hallazgos ecográficos fetales influyeron en la evolución y finalización de la gestación. El diagnóstico de periorquitis meconial fue confirmado postnatalmente en los tres casos: en el 1er caso a término, se descartó patología tumoral escrotal y no requirió cirugía abdominal; en los otros dos pacientes se indicó finalizar la gestación tras el diagnóstico prenatal y se realizó cirugía inguino-escrotal y abordaje intestinal por la peritonitis meconial.El diagnóstico ecográfico prenatal de periorquitis meconial obliga a un seguimiento ecográfico estricto del feto al ser un marcador específico de perforación intestinal, que puede conllevar la finalización de la gestación y evitar la aparición de una peritonitis meconial complicada.

Published
2019

33. [Post chemoterapy febrile neutropenia. Length of stay and experience in our population]

Author

Íñigo, Pérez-Heras, Roberto Carlos, Raynero-Mellado, Raquel, Díaz-Merchán, and Nerea, Domínguez-Pinilla

Subjects
Male, Risk Factors, Neoplasms, Humans, Antineoplastic Agents, Female, Prospective Studies, Length of Stay, Child, Infections, Febrile Neutropenia, Retrospective Studies
Abstract

Infections are significant cause of morbidity and mortality in cancer patients (mortality is estimated at around 3%). Febrile neutropenia often leads to the hospitalisation of cancer patients, increasing the risk of nosocomial infection, as well as health costs due to the hospital admission.An ambispective (01 July 2015 - 12 July 2018) observational study was conducted on all episodes of chemotherapy-induced febrile neutropenia in a paediatric population. A record was made of age, gender, weight percentile (WHO), length of hospital stay (days), temperature (oC), microbial isolation, infectious source, antibiotic or antifungal prophylaxis, haemoglobin (g/dl), platelets (/mmThe study included 69 patients, and 101 episodes were recorded. The mean stay was 7.43 days (median 6 days). Microbial isolation was found in 44.6% of the episodes, with no infectious source identified in 36% of them. An inverse correlation was found between haemoglobin, platelets, and lymphocytes on admission and the hospital stay (-0.356: P=.001, -0.216: P=.042, and -0.216: P=.042, respectively). The mean stay was greater if there was a CRP90mg/L (10.94 vs. 6.66 days, P=.017), if PCT1ng/ml (16.50 vs. 6.77 days, P=.0002), if ≤ 100 neutrophils (8.27 vs. 5.04 days P=.039) on admission, and if there was microbe isolation (9.54 vs. 5.78 days P=.006).The relationship between haemoglobin, platelets, and lymphocytes on admission and the mean stay is inversely proportional. In addition, those patients with ≤100 neutrophils, CRP90mg/L, and PCT1ng/ml on admission had a longer hospital stay.

Published
2019

34. Dietary inflammatory index and all-cause mortality in large cohorts: The SUN and PREDIMED studies

Author

L. Parra, Luis V. García, Cinta Valls-Pedret, Patricia Guillem-Saiz, Josep A. Tur, María P. Portillo, J. Vila, Estefanía Toledo, R. Martí Massó, E. de la Cruz, José I. González, J. de Irala, L. Garcia-Pérez, Simona Giardina, J.A. Cabeza-Beunza, I. Bautista Castaño, R. Osma, Alejandro Diaz, Ana Jover, M. Mata, Laura Quiles, Elena Martinez, T. Macua-Martínez, T. Elcarte-Lopez, Daniel Muñoz-Aguayo, Andrés Díaz-López, I. Duaso, Christopher Papandreou, L. Mellado, Manuel Leal, Carlos Ferreira, M.L. Garcés Ducar, M.J. Férnandez Rodríguez, I. Falcón Sanabria, P. Pascual-Pascual, L. Mengual, M.T. Martín, V. Velasco García, C. Simón García, G. Mestres, R. Benítez Pont, M. Ginard, Manuel Ortega-Calvo, L. Fernández Urzainqui, Susana Munuera, A. Fernandez Montero, James R. Hébert, E. Maestre, J. Amat, Miquel Fiol, Antonio García-Rodríguez, M. Vivó, Ernest Vinyoles, A. Ramos, B. Macías Gutiérrez, A. Casi, F. Artal-Moneva, M.A. Rodríguez, I. González-Monje, I. Maldonado Díaz, José V. Sorlí, Miguel-Angel Muñoz, Josep Basora-Gallisà, Dolores Corella, J. Gil Zarzosa, J. Alvarez-Pérez, M.A. Rovira, Mònica Bulló, Maira Bes-Rastrollo, P. Iglesias, N. Tort, Adriano Marçal Pimenta, S. Sánchez-Navarro, J. San Vicente, Pilar Buil-Cosiales, José Alfredo Martínez, E. Gutierrez, A. Proenza, Cristina Razquin, Paola Quifer-Rada, J. Marrugat, A.J. Santana Santana, Olga Castañer, Javier Rekondo, F. Trias, Magí Farré, J.M. Lozano-Rodriguez, Carlos Muñoz-Bravo, Marta Evelia Aparicio García, G. Mena, Leticia Miró-Moriano, Anna Tresserra-Rimbau, Z. Vazquez Ruiz, S. Tello, P. Baby, M.J. Ariz-Arnedo, J. García, M. Donazar, Emili Corbella, Jordi Salas-Salvadó, J. Fernandez-Crehuet, C. Simón, J.M. Baena, C. Murillo, Amelia Marti, A. Brau, H. Schröder, Rafael Balanza, C. Iglesias, R. Pedret, C. Oreja-Arrayago, J. Clos, R. Villanueva Moreno, V. Pascual, C. Lopez del Burgo, Raquel Pimienta González, Mercè Serra-Mir, Luis Forga, Helmut Schröder, Alex Medina-Remón, Javier Díez-Espino, C. de Juan, M. Amorós, M.D. Martínez-Mazo, D. Godoy, Olga Portolés, L. Quinzavos, Nancy Babio, Nerea Becerra-Tomás, J. Altirriba, P. Martínez, Carolina Donat-Vargas, N. Rosique Esteban, P. Villanueva, Ramon Estruch, Albert Goday, M. Tafalla, Alfredo Gea, R. de la Torre, F. Martin, B. Sanjulián, Ana García-Arellano, Y. García, Alvaro Alonso, P. Román, M. García-Valdueza, M.T. Barrio Lopez, N. Ibarrola, Marisa Guillén, Francisco Javier Basterra-Gortari, M. Liroz, Joan Fernández-Ballart, I. Bobe, F. Paris, P. Pascual Pascual, E. Manzano, Ricardo Gómez-Huelgas, F. Sarmiendo de la Fe, José Lapetra, R. Navajas, J. García Roselló, E. Sanz, F. Fiol, A. Baca Osorio, A.I. Castellote-Bargalló, J.V. Extremera-Urabayen, Carmen Sayón-Orea, I. Montull, Xavier Corbella, Sebastián Cervantes, T. del Hierro, Nitin Shivappa, E. Solis, Jorge M. Núñez-Córdoba, I. Zazpe Garcıa, A. Parra-Osés, Rosa Casas, Francisco Guillén-Grima, A. Altés, F.J. Giménez, Itziar Salaverria, M.C. Yuste, Carolina Ortega-Azorín, A. Carratalá-Calvo, E. Vargas López, F. Bestard, Eva M. Asensio, Paula Carrasco, T. Cervello, J.J. Sánchez Luque, Raul Ramallal, A. Isach, Ariadna Rovira, Juan Carlos Martínez-González, M. Oller, Francesc Francés, Lluis Serra-Majem, Montse Cofán, J.M. Santos-Lozano, Julia Wärnberg, C. Arroyo-Azpa, I. Sarasa, E. Díez Benítez, Guiem Frontera, J. Rekondo, Manuel Serrano-Martínez, Ana Pérez-Heras, Emilio Ros, I. Felipe, C. Domínguez-Espinaco, Carmen Saiz, M.I. Santamaría, Francisca Lahortiga, E. Figuerido-Garmendia, I. Pla, J. Benavent, Marta Guasch-Ferré, J.A. Tabar-Sarrias, P. Hernandez, X. Pintó-Salas, Rafel M. Prieto, C. Valero-Barceló, Albert Salas-Huetos, A. Loma-Osorio, M.T. Bonet, E. Arina-Vergara, P.A. de la Rosa, C. de la Fuente, J. Basells, Jaime Algorta, R. Segarra, A. Guarner, Rocío Barragán, S. Vaquero Diaz, Roberto Elosua, A. Sánchez Tainta, M. Bianchi Alba, Pilar Roura, Casandra Riera, Ana Galera, N. Molina, P. Cia-Lecumberri, J.A. Munar, Jesús Vizcaíno, J. de Diego Salas, J.M. Esparza-López, R. M. Lamuela-Raventos, A. Ruiz Zambrana, Aleix Sala-Vila, Amelia Marí-Sanchis, L. Coll, A.F. Barcena, Miguel Ángel Martínez-González, J.J. Beunza, Y. Corchado, M.S. Sánchez, Mónica Doménech, J. Toledo-Atucha, E. Goni-Ochandorena, Silvia Canudas, Raquel de Deus Mendonça, M. Cabre, O. Coltell, Miguel Ruiz-Canela, Javier Llorca, M.A. Pages, M.C. López Sabater, Guillermo T. Sáez, S. Francisco, M. Araque, Almudena Sánchez-Villegas, Silvia Carlos, Carmen Cabezas, Dora Romaguera, M. Llauradó, S. Benito Corchon, A. Rico, M.J. Lasanta-Sáez, C. Molina, C. Viñas, Rebeca Fernández-Carrión, M.A. Fernandez, Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (España), Centro Nacional de Investigaciones Cardiovasculares (España), European Commission, Ministerio de Ciencia e Innovación (España), Fundación Mapfre, Junta de Andalucía, Generalitat de Catalunya, Generalitat Valenciana, and Diputación Foral de Navarra

Subjects
Adult, Male, 0301 basic medicine, medicine.medical_specialty, Mediterranean diet, 030209 endocrinology & metabolism, Context (language use), Type 2 diabetes, Diet, Mediterranean, Critical Care and Intensive Care Medicine, Dietary inflammatory index, Body Mass Index, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Internal medicine, Humans, Medicine, Obesity, Prospective Studies, Mortality, Prospective cohort study, Randomized Controlled Trials as Topic, Inflammation, 030109 nutrition & dietetics, Nutrition and Dietetics, business.industry, Smoking, Hazard ratio, Middle Aged, medicine.disease, Diet, C-Reactive Protein, Diabetes Mellitus, Type 2, Cohort, Patient Compliance, Cohort studies, Female, business, CRP, Cohort study
Abstract

[Background]: Inflammation is known to be related to the leading causes of death including cardiovascular disease, several types of cancer, obesity, type 2 diabetes, depression-suicide and other chronic diseases. In the context of whole dietary patterns, the Dietary Inflammatory Index (DII®) was developed to appraise the inflammatory potential of the diet. [Objective]: We prospectively assessed the association between DII scores and all-cause mortality in two large Spanish cohorts and valuated the consistency of findings across these two cohorts and results published based on other cohorts., [Design]: We assessed 18,566 participants in the “Seguimiento Universidad de Navarra” (SUN) cohort followed-up during 188,891 person-years and 6790 participants in the “PREvencion con DIeta MEDiterránea” (PREDIMED) randomized trial representing 30,233 person-years of follow-up. DII scores were calculated in both cohorts from validated FFQs. Higher DII scores corresponded to more proinflammatory diets. A total of 230 and 302 deaths occurred in SUN and PREDIMED, respectively. In a random-effect meta-analysis we included 12 prospective studies (SUN, PREDIMED and 10 additional studies) that assessed the association between DII scores and all-cause mortality., [Results]: After adjusting for a wide array of potential confounders, the comparison between extreme quartiles of the DII showed a positive and significant association with all-cause mortality in both the SUN (hazard ratio [HR] = 1.85; 95% CI: 1.15, 2.98; P-trend = 0.004) and the PREDIMED cohort (HR = 1.42; 95% CI: 1.00, 2.02; P-trend = 0.009). In the meta-analysis of 12 cohorts, the DII was significantly associated with an increase of 23% in all-cause mortality (95% CI: 16%–32%, for the highest vs lowest category of DII)., [Conclusion]: Our results provide strong and consistent support for the hypothesis that a pro-inflammatory diet is associated with increased all-cause mortality. The SUN cohort and PREDIMED trial were registered at clinicaltrials.gov as NCT02669602 and at isrctn.com as ISRCTN35739639, respectively., Supported by the official funding agency for biomedical research of the Spanish Government, Instituto de Salud Carlos III (ISCIII), through grants provided to research networks specifically developed for the trial (RTIC G03/140, to R.E.; RTIC RD 06/0045, to Miguel A. Martínez-González) and through Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBERobn), and by grants from Centro Nacional de Investigaciones Cardiovasculares (CNIC 06/2007), Fondo de Investigación Sanitaria–Fondo Europeo de Desarrollo Regional (Proyecto de Investigación (PI) 04-2239, PI 05/2584, CP06/00100, PI07/0240, PI07/1138, PI07/0954, PI 07/0473, PI10/01407, PI10/02658, PI11/01647, P11/02505, PI13/00462, PI13/00615, PI13/01090, PI14/01668, PI14/01798, PI14/01764), Ministerio de Ciencia e Innovación (Recursos y teconologia agroalimentarias(AGL)-2009-13906-C02 and AGL2010-22319-C03 and AGL2013-49083-C3-1- R), Fundación Mapfre 2010, the Consejería de Salud de la Junta de Andalucía (PI0105/2007), the Public Health Division of the Department of Health of the Autonomous Government of Catalonia, Generalitat Valenciana (Generalitat Valenciana Ayuda Complementaria (GVACOMP) 06109, GVACOMP2010-181, GVACOMP2011-151), Conselleria de Sanitat y, PI14/01764 AP; Atención Primaria (CS) 2010-AP-111, and CS2011-AP-042), and Regional Government of Navarra (P27/2011).). Drs. Shivappa and Hébert were supported by grant number R44DK103377 from the United States National Institute of Diabetes and Digestive and Kidney Diseases.

Published
2019

36. Dietary inflammatory index and all-cause mortality in large cohorts: The SUN and PREDIMED studies

Author

Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (España), Centro Nacional de Investigaciones Cardiovasculares (España), European Commission, Ministerio de Ciencia e Innovación (España), Fundación Mapfre, Junta de Andalucía, Generalitat de Catalunya, Generalitat Valenciana, Diputación Foral de Navarra, García-Arellano, Ana, Martínez-González, Miguel Ángel, Ramallal, Raúl, Salas-Salvadó, Jordi, Hébert, James R., Corella, Dolores, Shivappa, Nitin, Forga, Luis, Schröder, Helmut, Muñoz-Bravo, C., Estruch, Ramón, Hernández, P., Murillo, C., Mestres, G., Mengual, L., Serra-Majem, Lluis, Juan, C.de, Romaguera, Dora, Ruiz-Canela, Miguel, Vizcaíno, J., Bautista Castaño, I., Mendonça, Raquel Bicudo Deus, Farré, M., Basora-Gallisa, J., Barrio López, M.T., Buil-Cosiales, Pilar, Sarmiendo de la Fe, F., Medina-Remón, Alexander, Sánchez Luque, J. J., Sorlí, J., Cervantes, S., Pérez-Heras, A., Gil Zarzosa, J., Villanueva Moreno, R., Goni-Ochandorena, E., Lasanta-Sáez, M.J., Cia-Lecumberri, P., Fernandez-Urzainqui, L., Sáiz, C., Schroder, H., Carrasco, P., Doménech, M., Mellado, L., Toledo-Atucha, J., Guillen-Grima, F., Marrugat, J., Sáez, G., Ruiz Zambrana, A., Miró-Moriano, L., Zazpe Garcia, I, Godoy, D., Segarra, R., Toledo, Estefania, Molina, C., Loma-Osorio, A., Martínez, E., Bulló, Mònica, Vinyoles, E., Estremera-Urabayen, J. V., García, Y., Simón, C., Amorós, M., Navajas, R., Sánchez-Navarro, S., Casi, A., Pimenta, A. M., Tabar-Sarrias, J. A., Cruz, E. de la, Pascual-Pascual, P., Riera, C., García-Pérez, L., Carratalá-Calvo, A., Sanchez-Tainta, A., Ariz-Arnedo, M.J., Galera, A., Arina-Vergara, E., Martínez-González, José, Munuera, S., Francés, F., Felipe, I., Martínez, P., Gea, A., Díaz-López, A., Santana Santana, A. J., Serra-Mir, Mercè, Ros, Emilio, Villanueva, P., Becerra-Tomás, Nerea, Rosique-Esteban, N., Papandreou, Christopher, García, J., Prieto, R., Bestard, F., Osma, R., Baena, J.M., Figuerido-Garmendia, E., Pla, I., Tafalla, M., Benavent, J., Sánchez, M. S., Proenza, A., García, M., Vivo, M., Garcés Ducar, M. L., Bonet, M.T., Casas, Ricard, Bobe, I., Altés, A., Ginard, M., Díez-Espino, Javier, López-Sabater, M. C., Wärnberg, Julia, Valls-Pedret, C., Basells, J., Serrano-Martinez, M., Giménez, F.J., Velasco García, V., González, R., González, J. I., Barragán, Rocío, Martín, F., Muñoz-Aguayo, Daniel, Elosua, Roberto, Rovira, A., Fernández-Rodríguez, M. J., Román, Pablo, Quifer-Rada, P., Fernández-Crehuet, Joaquín, Llorca, J., Tort, N., Iglesias, P., Clos, J., Ferreira, C., Lopez del Burgo, C., Llauradó, M., Sarasa, Iziar, Jover, A., Altirriba, J., Bianchi Alba, M., Lahortiga, F., García-Rodriguez, A., Cabeza-Beunza, J. A., Fernández-Ballart, J., Pascual, V., Pages, M.A., del Hierro, T., Mata, M., Corbella, X., García, L., Maestre, E., Barcena, A. F., Sorlí, José V., Carlos, Silvia, Balanza, R., Rodríguez, M. A., Pedret, R., Castañer, Olga, Oreja-Arrayago, C., Ortega-Azorín, Carolina, Cervello, T., Maldonado Díaz, I., Ramos, A., Gómez-Huelgas, R., García Roselló, J., Benito Crochon, S., Arroyo-Azpa, C., Guillén, M., Martín, M. T., Coltell, O., García-Valdueza, M., Frontera, G., Fernandez Montero, A., Rosa, Pedro Antonio de la, Tur, Josep A., Díez Benítez, E., Razquin, Cristina, Molina, N., Salaverria Lete, Itziar, Amat, J., Alonso, A., Araque, M., Fernández-Carrión, Rebeca, Montull, I., Asensio, Eva M., Algorta, J., Portolés, Olga, Duaso, I., Sanz, E., Donat-Vargas, Carolina, Sayón-Orea, Carmen, Guarner, A., Fiol, F., Guasch‐Ferré, Marta, Simón García, C., Oller, M., Brau, A., Benítez Pont, R., Sánchez-Villegas, A., Diego Salas, J. de, Domínguez-Espinaco, C., Vaquero-Díaz, S., Lozano-Rodríguez, J.M., Marti, A., Núñez-Córdoba, J.M., Vázquez Ruiz, Z., Roura, P., Babio, Nancy, Baca Osorio, A., Valero-Barcelo, C., Basterra-Gortari, F. Javier, Salas-Huetos, A., Munar, J.A., Elcarte-Lopez, T., Donazar, M., San Vicente, J., Santamaria, M. I., Isach, A., Yuste, M. C., Ortega-Calvo, Manuel, Pintó-Salas, X., Trias, Ferrán, Muñoz, Miguel Ángel, Viñas, C., Esparza-López, J.M., Martínez-Mazo, M.D., Bes-Rastrollo, M., Vila, J., Castellote-Bargalló, Ana I., Leal, M., Artal-Moneva, F., Coll, L., Lamuela-Raventós, Rosa M., Torre, Rafael de la, Tresserra-Rimbau, A., Quinzavos, L., Sanjulian, B., Macua-Martínez, T., Irala, J. de, Sala-Vila, Aleix, Tello, S., Beunza, J.J., Francisco, S., Falcón Sanabria, I., Díaz, A., Solis, E., Lapetra, José, Mena, G., Liroz, M., Manzano, E., Corchado, Y., Goday, A., Gonzaláz-Monje, I., Rovira, M.A., Iglesias, C., Macías Gutiérrez, B., Parra, L., Álvarez-Pérez, J., Cabezas, C., Quiles, L., Baby, P., Ibarrola-Jurado, Nuria, Cabre, M., Parra-Osés, A., Cofán, Montserrat, Fuente, Carmen de la, Santos-Lozano, J. M., Guillem-Saiz, P., Martínez, J. A., Fernández, M., Mari-Sanchıs, A., Rico, A., Giardina, S., Canudas, Silvia, Paris, F., Marti Massó, R., Gutierrez, E., Corbella, Emili, Fiol, Miquel, Vargas López, E., Portillo, María P., Rekondo, Javier, Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (España), Centro Nacional de Investigaciones Cardiovasculares (España), European Commission, Ministerio de Ciencia e Innovación (España), Fundación Mapfre, Junta de Andalucía, Generalitat de Catalunya, Generalitat Valenciana, Diputación Foral de Navarra, García-Arellano, Ana, Martínez-González, Miguel Ángel, Ramallal, Raúl, Salas-Salvadó, Jordi, Hébert, James R., Corella, Dolores, Shivappa, Nitin, Forga, Luis, Schröder, Helmut, Muñoz-Bravo, C., Estruch, Ramón, Hernández, P., Murillo, C., Mestres, G., Mengual, L., Serra-Majem, Lluis, Juan, C.de, Romaguera, Dora, Ruiz-Canela, Miguel, Vizcaíno, J., Bautista Castaño, I., Mendonça, Raquel Bicudo Deus, Farré, M., Basora-Gallisa, J., Barrio López, M.T., Buil-Cosiales, Pilar, Sarmiendo de la Fe, F., Medina-Remón, Alexander, Sánchez Luque, J. J., Sorlí, J., Cervantes, S., Pérez-Heras, A., Gil Zarzosa, J., Villanueva Moreno, R., Goni-Ochandorena, E., Lasanta-Sáez, M.J., Cia-Lecumberri, P., Fernandez-Urzainqui, L., Sáiz, C., Schroder, H., Carrasco, P., Doménech, M., Mellado, L., Toledo-Atucha, J., Guillen-Grima, F., Marrugat, J., Sáez, G., Ruiz Zambrana, A., Miró-Moriano, L., Zazpe Garcia, I, Godoy, D., Segarra, R., Toledo, Estefania, Molina, C., Loma-Osorio, A., Martínez, E., Bulló, Mònica, Vinyoles, E., Estremera-Urabayen, J. V., García, Y., Simón, C., Amorós, M., Navajas, R., Sánchez-Navarro, S., Casi, A., Pimenta, A. M., Tabar-Sarrias, J. A., Cruz, E. de la, Pascual-Pascual, P., Riera, C., García-Pérez, L., Carratalá-Calvo, A., Sanchez-Tainta, A., Ariz-Arnedo, M.J., Galera, A., Arina-Vergara, E., Martínez-González, José, Munuera, S., Francés, F., Felipe, I., Martínez, P., Gea, A., Díaz-López, A., Santana Santana, A. J., Serra-Mir, Mercè, Ros, Emilio, Villanueva, P., Becerra-Tomás, Nerea, Rosique-Esteban, N., Papandreou, Christopher, García, J., Prieto, R., Bestard, F., Osma, R., Baena, J.M., Figuerido-Garmendia, E., Pla, I., Tafalla, M., Benavent, J., Sánchez, M. S., Proenza, A., García, M., Vivo, M., Garcés Ducar, M. L., Bonet, M.T., Casas, Ricard, Bobe, I., Altés, A., Ginard, M., Díez-Espino, Javier, López-Sabater, M. C., Wärnberg, Julia, Valls-Pedret, C., Basells, J., Serrano-Martinez, M., Giménez, F.J., Velasco García, V., González, R., González, J. I., Barragán, Rocío, Martín, F., Muñoz-Aguayo, Daniel, Elosua, Roberto, Rovira, A., Fernández-Rodríguez, M. J., Román, Pablo, Quifer-Rada, P., Fernández-Crehuet, Joaquín, Llorca, J., Tort, N., Iglesias, P., Clos, J., Ferreira, C., Lopez del Burgo, C., Llauradó, M., Sarasa, Iziar, Jover, A., Altirriba, J., Bianchi Alba, M., Lahortiga, F., García-Rodriguez, A., Cabeza-Beunza, J. A., Fernández-Ballart, J., Pascual, V., Pages, M.A., del Hierro, T., Mata, M., Corbella, X., García, L., Maestre, E., Barcena, A. F., Sorlí, José V., Carlos, Silvia, Balanza, R., Rodríguez, M. A., Pedret, R., Castañer, Olga, Oreja-Arrayago, C., Ortega-Azorín, Carolina, Cervello, T., Maldonado Díaz, I., Ramos, A., Gómez-Huelgas, R., García Roselló, J., Benito Crochon, S., Arroyo-Azpa, C., Guillén, M., Martín, M. T., Coltell, O., García-Valdueza, M., Frontera, G., Fernandez Montero, A., Rosa, Pedro Antonio de la, Tur, Josep A., Díez Benítez, E., Razquin, Cristina, Molina, N., Salaverria Lete, Itziar, Amat, J., Alonso, A., Araque, M., Fernández-Carrión, Rebeca, Montull, I., Asensio, Eva M., Algorta, J., Portolés, Olga, Duaso, I., Sanz, E., Donat-Vargas, Carolina, Sayón-Orea, Carmen, Guarner, A., Fiol, F., Guasch‐Ferré, Marta, Simón García, C., Oller, M., Brau, A., Benítez Pont, R., Sánchez-Villegas, A., Diego Salas, J. de, Domínguez-Espinaco, C., Vaquero-Díaz, S., Lozano-Rodríguez, J.M., Marti, A., Núñez-Córdoba, J.M., Vázquez Ruiz, Z., Roura, P., Babio, Nancy, Baca Osorio, A., Valero-Barcelo, C., Basterra-Gortari, F. Javier, Salas-Huetos, A., Munar, J.A., Elcarte-Lopez, T., Donazar, M., San Vicente, J., Santamaria, M. I., Isach, A., Yuste, M. C., Ortega-Calvo, Manuel, Pintó-Salas, X., Trias, Ferrán, Muñoz, Miguel Ángel, Viñas, C., Esparza-López, J.M., Martínez-Mazo, M.D., Bes-Rastrollo, M., Vila, J., Castellote-Bargalló, Ana I., Leal, M., Artal-Moneva, F., Coll, L., Lamuela-Raventós, Rosa M., Torre, Rafael de la, Tresserra-Rimbau, A., Quinzavos, L., Sanjulian, B., Macua-Martínez, T., Irala, J. de, Sala-Vila, Aleix, Tello, S., Beunza, J.J., Francisco, S., Falcón Sanabria, I., Díaz, A., Solis, E., Lapetra, José, Mena, G., Liroz, M., Manzano, E., Corchado, Y., Goday, A., Gonzaláz-Monje, I., Rovira, M.A., Iglesias, C., Macías Gutiérrez, B., Parra, L., Álvarez-Pérez, J., Cabezas, C., Quiles, L., Baby, P., Ibarrola-Jurado, Nuria, Cabre, M., Parra-Osés, A., Cofán, Montserrat, Fuente, Carmen de la, Santos-Lozano, J. M., Guillem-Saiz, P., Martínez, J. A., Fernández, M., Mari-Sanchıs, A., Rico, A., Giardina, S., Canudas, Silvia, Paris, F., Marti Massó, R., Gutierrez, E., Corbella, Emili, Fiol, Miquel, Vargas López, E., Portillo, María P., and Rekondo, Javier

Abstract

[Background]: Inflammation is known to be related to the leading causes of death including cardiovascular disease, several types of cancer, obesity, type 2 diabetes, depression-suicide and other chronic diseases. In the context of whole dietary patterns, the Dietary Inflammatory Index (DII®) was developed to appraise the inflammatory potential of the diet. [Objective]: We prospectively assessed the association between DII scores and all-cause mortality in two large Spanish cohorts and valuated the consistency of findings across these two cohorts and results published based on other cohorts., [Design]: We assessed 18,566 participants in the “Seguimiento Universidad de Navarra” (SUN) cohort followed-up during 188,891 person-years and 6790 participants in the “PREvencion con DIeta MEDiterránea” (PREDIMED) randomized trial representing 30,233 person-years of follow-up. DII scores were calculated in both cohorts from validated FFQs. Higher DII scores corresponded to more proinflammatory diets. A total of 230 and 302 deaths occurred in SUN and PREDIMED, respectively. In a random-effect meta-analysis we included 12 prospective studies (SUN, PREDIMED and 10 additional studies) that assessed the association between DII scores and all-cause mortality., [Results]: After adjusting for a wide array of potential confounders, the comparison between extreme quartiles of the DII showed a positive and significant association with all-cause mortality in both the SUN (hazard ratio [HR] = 1.85; 95% CI: 1.15, 2.98; P-trend = 0.004) and the PREDIMED cohort (HR = 1.42; 95% CI: 1.00, 2.02; P-trend = 0.009). In the meta-analysis of 12 cohorts, the DII was significantly associated with an increase of 23% in all-cause mortality (95% CI: 16%–32%, for the highest vs lowest category of DII)., [Conclusion]: Our results provide strong and consistent support for the hypothesis that a pro-inflammatory diet is associated with increased all-cause mortality. The SUN cohort and PREDIMED trial were registered at clinicaltrials.gov as NCT02669602 and at isrctn.com as ISRCTN35739639, respectively.

Published
2019

38. Community-onset extended-spectrum β-lactamase producing Escherichia coli in urinary tract infections in children from 2015 to 2016: Prevalence, risk factors, and resistances

Author

Juan Carlos Sanchez-Gomez, Iñigo Pérez Heras, Laura Ruano-de-Pablo, Begoña Losada-Pinedo, and Pedro Beneyto-Martin

Subjects
0301 basic medicine, Male, medicine.medical_specialty, medicine.drug_class, Urinary system, 030106 microbiology, Antibiotics, Observational Study, β-lactamases, Drug resistance, medicine.disease_cause, Vesicoureteral reflux, beta-Lactamases, community-acquired infections, 03 medical and health sciences, 0302 clinical medicine, spain/epidemiology, Risk Factors, Internal medicine, Drug Resistance, Multiple, Bacterial, medicine, Escherichia coli, Prevalence, Humans, 030212 general & internal medicine, Escherichia coli Infections, Community onset, Retrospective Studies, Vesico-Ureteral Reflux, business.industry, Age Factors, Infant, Retrospective cohort study, General Medicine, medicine.disease, Anti-Bacterial Agents, Multiple drug resistance, Hospitalization, Spain, Urinary Tract Infections, Female, business, Research Article
Abstract

Over the past 10 years, the resistances among microbes are increasing gradually in Europe and greater resistances are seen in southern countries. We studied the prevalence of community-onset ESBL-producing Escherichia coli urinary tract infections in children. As secondary objectives, we analyzed associated risk factors and the resistance patterns in ESBL-producing E coli isolates. Retrospective observational study in a tertiary care hospital about children ≤14 years old with community-onset E coli urinary tract infection. The variables studied were age, sex, ESBL-producing, antibiotic therapy 7 to 30 days before the infection, hospitalization 7 to 30 days before the infection, nefrourologic pathology, and vesicoureteral reflux. Between January 1st, 2015 and December 31st, 2016, 229 isolates of E coli were obtained, of whom 21 (9.2%) where ESBL-producing E coli. Median age in non-ESBL-producing was 18 months versus 7 months in ESBL-producing group. Fourteen (66%) of the ESBL-producing group were men (P = .001), 5 (23.8%) were hospitalized 30 days before the infection (P = .001), 12 (57.1%) had nefrourological pathology (P = .003), 6 (28.5%) had vesicoureteral reflux (P = .032). Previous antibiotic therapy was not statistically significant. Multiple regression analyses between sex and 30 days previous hospitalization were r = 3.51 (P = .0001). Multidrug resistant isolates among ESBL-producing E coli was 12 (57%). The retrospective study allowed assessing the problem of ESBL-producing isolates in the outpatient settings. Some risk factors from past studies were confirmed and a combined risk is suggested. The resistant spectrum should be taken into account when choosing antibiotic regimens.

Published
2018

39. Legume consumption is inversely associated with type 2 diabetes incidence in adults: A prospective assessment from the PREDIMED study

Author

Miguel Fiol, Patricia Guillem-Saiz, Leticia Miró-Moriano, Josep A. Tur, N. Ibarrola, A.I. Castellote-Bargalló, J. Boj, Estefanía Toledo, Ana Jover, V. Extremera-Urabayen, E. Manzano, I. González-Monje, Juan Carlos Martínez-González, María P. Portillo, O. Portolés, C. Simón, Olga Castañer, B. Sanjulián, S. Sánchez-Navarro, R. González, Rosa M. Lamuela-Raventós, R. Pedret, N. Tort, J. Pérez-Cabrera, J. García, J. Portu-Zapirain, Carolina Ortega-Azorín, Dolors Montañes, Helmut Schröder, Guillermo Frontera, Mònica Bulló, Lluis Serra-Majem, J.M. Santos-Lozano, F. Trias, Nuria Rosique-Esteban, P. Martínez, C. Iglesias, Magí Farré, J.M. Lozano-Rodriguez, Valentina Ruiz-Gutiérrez, Luis Forga, L.T. Casañas-Quintana, I. Sarasa, C. de Juan, R. Benítez Pont, Javier Díez-Espino, L. Parra, M. Ginard, Josep Basora, Luis V. García, Rosa Casas, Fernando Arós, L. Quinzavos, A. Larrauri, A. Guarner, Ramon Estruch, A.M. Alonso-Gómez, Aleix Sala-Vila, E. Montero Romero, Cinta Valls-Pedret, F. Bestard, Jesús Berjón, Y. García, José Manuel Santos-Lozano, Emili Corbella, J. Clos, Christopher Papandreou, E. Maestre, R.E. Sosa-Also, J. Altirriba, M. Bianchi Alba, José I. González, Eva M. Asensio, Paula Carrasco, J. Vila, J.A. García Pastor, J. Medina-Ponce, Jordi Salas-Salvadó, L. Mellado, Amelia Marti, Estíbaliz Goñi, Joan Fernández-Ballart, Ana García-Arellano, Pilar Roura, Albert Salas-Huetos, A. Loma-Osorio, E. Jurado-Ruiz, Casandra Riera, Pilar Buil-Cosiales, Ana Galera, J. Gil Zarzosa, Miquel Fiol, Fabiola Márquez, Alfredo García-Layana, Maria Luisa García, B.V. Díaz-González, M.A. Pages, Enrique Gómez-Gracia, D. Godoy, F. Paris, T. del Hierro, F. Cortés-Ugalde, Ernest Vinyoles, J. Marrugat, V. Velasco García, Olga Portolés, F. Sarmiento de la Fe, Roberto Elosua, F.J. García-Corte, J. Timiraus-Fernández, Ana Pérez-Heras, P. Baby, M. Aldamiz-Echevarría, Montse Cofán, Y. Corchado, J. Villanueva-Telleria, T. Sagredo-Arce, C. Valero-Barceló, M.C. Belló, J. Frigola, J.J. Cabré, B. Churio-Beraza, Montserrat Fitó, P. Román, A. Proenza, M.C. López Sabater, P. Iglesias, J.M. Baena, M.T. Martín, Javier Rekondo, S. Vaquero-Diaz, G. Mestres, Nancy Babio, J. Diez-Espino, M. Liroz, M. García-Valdueza, J. Gállego, J.M. Castillo Anzalas, M.V. Gueto Rubio, L. Coll, S. Tello, Manuel Moñino, Anna Tresserra-Rimbau, Susana Munuera, J. Sánchez Perona, Guillermo T. Sáez, Gemma Flores, J. Amat, J. Benavent, M. Sorlí, Manuel Ortega-Calvo, A. Altés, Dolores Corella, Inmaculada Bautista-Castaño, Jacqueline Álvarez-Pérez, Marisa Guillén, Rafel M. Prieto, Ángel M. Alonso-Gómez, A. Ramos, Daniel Muñoz-Aguayo, M.A. Rovira, E. de la Cruz, Manuel Serrano-Martínez, A. Urtasun-Samper, R. Osma, R. de la Torre, J. Basells, N. Berrade, Jaime Algorta, R. Segarra, I. Duaso, Emilio Ros, C. Domínguez-Espinaco, J.A. Munar, A. Brau, M.I. Santamaría, A. Medina-Renom, Mercè Serra-Mir, Jesús Vizcaíno, J. de Diego Salas, M. Amorós, Z. Vázquez, Ana María Castro, E. Sanz, M. García-García, F. Fiol, F.J. Giménez, Itziar Salaverria, M. Vivó, Elena H. Martinez-Lapiscina, C. Viñas, J. García Roselló, A. Baca Osorio, A. Carratalá-Calvo, Francesc Francés, Julia Wärnberg, C. Arroyo-Azpa, Rebeca Fernández-Carrión, E.M. Díaz-Benítez, O. Coltell, Miguel Ruiz-Canela, M.D. Vigata-López, F. Martin, M.S. Sánchez, L. Mengual, Mónica Doménech, V. Pascual, Nerea Becerra-Tomás, Ricardo Gómez-Huelgas, Xavier Corbella, M.C. Yuste, E. Vargas López, Carmen Saiz, J.J. Sánchez Luque, I. Pla, S. Francisco, F. Aros, Marta Guasch-Ferré, Almudena Sánchez-Villegas, A. Isach, Ariadna Rovira, Marta Fanlo-Maresma, Carmen Cabezas, Dora Romaguera, L. Garcia-Pérez, M. Oller, M.T. Bonet, M. Mata, Sonia Eguaras, Ana Sánchez-Tainta, M. Llauradó, J. Costa-Vizcaino, Laura Quiles, Paola Quifer-Rada, C. Molina, N. Molina, M.T. Arceiz Campo, Cristina Ruano-Rodríguez, J.M. Verdú, Rocío Barragán, and Andrés Díaz-López

Subjects
0301 basic medicine, Gerontology, Blood Glucose, Male, Lentils, Mediterranean diet, PREDIMED-study, 030209 endocrinology & metabolism, Context (language use), Type 2 diabetes, Critical Care and Intensive Care Medicine, Lower risk, Diet, Mediterranean, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Diabetes mellitus, medicine, Humans, Prospective Studies, Glycemic, Adiposity, Aged, Proportional Hazards Models, 030109 nutrition & dietetics, Nutrition and Dietetics, business.industry, Fabaceae, Middle Aged, medicine.disease, Legumes, Diet, Glycemic index, Quartile, Diabetes Mellitus, Type 2, Glycemic Index, Female, business, Demography, Follow-Up Studies
Abstract

Background & aims: Legumes, a low-energy, nutrient-dense and low glycemic index food, have shown beneficial effects on glycemic control and adiposity. As such, legumes are widely recommended in diabetic diets, even though there is little evidence that their consumption protects against type 2 diabetes. Therefore the aim of the present study was to examine the associations between consumption of total legumes and specific subtypes, and type 2 diabetes risk. We also investigated the effect of theoretically substituting legumes for other protein- or carbohydrate-rich foods. Methods: Prospective assessment of 3349 participants in the PREvención con DIeta MEDiterránea (PREDIMED) study without type 2 diabetes at baseline. Dietary information was assessed at baseline and yearly during follow-up. We used Cox regression models to estimate hazard ratios (HRs) and 95% confidence intervals (95% CIs) for type-2 diabetes incidence according to quartiles of cumulative average consumption of total legumes, lentils, chickpeas, dry beans and fresh peas. Results: During a median follow-up of 4.3 years, 266 new cases of type 2 diabetes occurred. Individuals in the highest quartile of total legume and lentil consumption had a lower risk of diabetes than those in the lowest quartile (HR: 0.65; 95% CI: 0.43, 0.96; P-trend = 0.04; and HR: 0.67; 95% CI: 0.46–0.98; P-trend = 0.05, respectively). A borderline significant association was also observed for chickpeas consumption (HR 0.68; 95% CI: 0.46, 1.00; P-trend = 0.06). Substitutions of half a serving/day of legumes for similar servings of eggs, bread, rice or baked potato was associated with lower risk of diabetes incidence. Conclusions: A frequent consumption of legumes, particularly lentils, in the context of a Mediterranean diet, may provide benefits on type 2 diabetes prevention in older adults at high cardiovascular risk. Trial registration: The trial is registered at http://www.controlled-trials.com (ISRCTN35739639). Registration date: 5th October 2005., The authors disclose no conflict of interest related with the article. Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (CIBEROBN) is an initiative of the Instituto de Salud Carlos III (ISCIII) of Spain which is supported by FEDER funds (CB06/03). Supported by the official funding agency for biomedical research of the Spanish government, ISCIII, through grants provided to research networks specifically developed for the trial (RTIC G03/140 and RD 06/0045) through CIBEROBN, and by grants from Centro Nacional de Investigaciones Cardiovasculares (CNIC 06/2007), Fondo de Investigación Sanitaria–FondoEuropeo de Desarrollo Regional (PI04–2239, PI05/2584, CP06/00100, PI07/0240, PI07/1138, PI07/0954, PI 07/0473, PI10/01407, PI10/02658, PI11/01647, and PI11/02505; PI13/00462), Ministerio de Ciencia e Innovación (AGL-2009–13906-C02 and AGL2010–22319-C03), Fundación Mapfre 2010, Consejería de Salud de la Junta de Andalucía (PI0105/2007), Public Health Division of the Department of Health of the Autonomous Government of Catalonia, Generalitat Valenciana (ACOMP06109, GVA-COMP2010–181, GVACOMP2011–151, CS2010-AP-111, and CS2011-AP-042), and the Navarra Regional Government (27/2011). The Fundación Patrimonio Comunal Olivarero and Hojiblanca SA (Málaga, Spain), California Walnut Commission (Sacramento, CA), Borges SA (Reus, Spain), and Morella Nuts SA (Reus, Spain) donated the olive oil, walnuts, almonds, and hazelnuts, respectively, used in the study. None of the funding sources played a role in the design, collection, analysis or interpretation of the data or in the decision to submit the manuscript for publication. Acknowledgements: The authors thank all the participants for their collaboration, all the PREDIMED personnel for their assistance and all the personnel of affiliated primary care centers for making the study possible. CIBEROBN is an initiative of ISCIII, Spain.

Published
2018

40. Dietary inflammatory index and all-cause mortality in large cohorts: The SUN and PREDIMED studies

Author

Garcia-Arellano, Ana, primary, Martínez-González, Miguel A., additional, Ramallal, Raul, additional, Salas-Salvadó, Jordi, additional, Hébert, James R., additional, Corella, Dolores, additional, Shivappa, Nitin, additional, Forga, Luis, additional, Schröder, Helmut, additional, Muñoz-Bravo, Carlos, additional, Estruch, Ramón, additional, Fiol, Miquel, additional, Lapetra, José, additional, Serra-Majem, Lluís, additional, Ros, Emilio, additional, Rekondo, Javier, additional, Toledo, Estefanía, additional, Razquin, Cristina, additional, Ruiz-Canela, Miguel, additional, Alonso, A., additional, Barrio Lopez, M.T., additional, Basterra-Gortari, F.J., additional, Benito Corchon, S., additional, Bes-Rastrollo, M., additional, Beunza, J.J., additional, Carlos, S., additional, Cervantes, S., additional, de Irala, J., additional, de la Rosa, P.A., additional, de la Fuente, C., additional, Donat-Vargas, C.L., additional, Donazar, M., additional, Fernandez Montero, A., additional, Gea, A., additional, Goni-Ochandorena, E., additional, Guillen-Grima, F., additional, Lahortiga, F., additional, Llorca, J., additional, Lopez del Burgo, C., additional, Mari-Sanchıs, A., additional, Marti, A., additional, Mendonça, R., additional, Nuñez-Cordoba, J.M., additional, Pimenta, A.M., additional, Rico, A., additional, Ruiz Zambrana, A., additional, Sayon-Orea, C., additional, Toledo-Atucha, J., additional, Vazquez Ruiz, Z., additional, Zazpe Garcıa, I., additional, Sánchez- Tainta, A., additional, Buil-Cosiales, P., additional, Díez-Espino, J., additional, Sanjulian, B., additional, Martínez, J.A., additional, Serrano-Martínez, M., additional, Extremera-Urabayen, J.V., additional, Garcia-Pérez, L., additional, Arroyo-Azpa, C., additional, Barcena, A.F., additional, Oreja-Arrayago, C., additional, Lasanta-Sáez, M.J., additional, Cia-Lecumberri, P., additional, Elcarte-Lopez, T., additional, Artal-Moneva, F., additional, Esparza-López, J.M., additional, Figuerido-Garmendia, E., additional, Tabar-Sarrias, J.A., additional, Fernández- Urzainqui, L., additional, Ariz-Arnedo, M.J., additional, Cabeza-Beunza, J.A., additional, Pascual-Pascual, P., additional, Martínez-Mazo, M.D., additional, Arina-Vergara, E., additional, Macua-Martínez, T., additional, Pascual Pascual, P., additional, Garcés Ducar, M.L., additional, Martí Massó, R., additional, Villanueva Moreno, R., additional, Parra-Osés, A., additional, Serra-Mir, M., additional, Pérez-Heras, A., additional, Viñas, C., additional, Casas, R., additional, Medina-Remon, A., additional, Villanueva, P., additional, Baena, J.M., additional, García, M., additional, Oller, M., additional, Amat, J., additional, Duaso, I., additional, García, Y., additional, Iglesias, C., additional, Simón, C., additional, Quinzavos, L., additional, Parra, L., additional, Liroz, M., additional, Benavent, J., additional, Clos, J., additional, Pla, I., additional, Amorós, M., additional, Bonet, M.T., additional, Martín, M.T., additional, Sánchez, M.S., additional, Altirriba, J., additional, Manzano, E., additional, Altés, A., additional, Cofán, M., additional, Valls-Pedret, C., additional, Sala-Vila, A., additional, Doménech, M., additional, Bulló, M., additional, Basora-Gallisa, J., additional, González, R., additional, Molina, C., additional, Mena, G., additional, Martínez, P., additional, Ibarrola, N., additional, Sorlí, J., additional, García Roselló, J., additional, Martin, F., additional, Tort, N., additional, Isach, A., additional, Babio, N., additional, Salas-Huetos, A., additional, Becerra-Tomás, N., additional, Rosique- Esteban, N., additional, Hernandez, P., additional, Canudas, S., additional, Papandreou, C., additional, Ferreira, C., additional, Cabre, M., additional, Mestres, G., additional, Paris, F., additional, Llauradó, M., additional, Pedret, R., additional, Basells, J., additional, Vizcaino, J., additional, Segarra, R., additional, Giardina, S., additional, Guasch-Ferré, M., additional, Díaz-López, A., additional, Fernández-Ballart, J., additional, Balanza, R., additional, Tello, S., additional, Vila, J., additional, de la Torre, R., additional, Muñoz-Aguayo, D., additional, Elosua, R., additional, Marrugat, J., additional, Schröder, H., additional, Molina, N., additional, Maestre, E., additional, Rovira, A., additional, Castañer, O., additional, Farré, M., additional, Sorli, J., additional, Carrasco, P., additional, Ortega-Azorín, C., additional, Asensio, E.M., additional, Osma, R., additional, Barragán, R., additional, Francés, F., additional, Guillén, M., additional, González, J.I., additional, Sáiz, C., additional, Portolés, O., additional, Giménez, F.J., additional, Coltell, O., additional, Fernández-Carrión, R., additional, Guillem-Sáiz, P., additional, González-Monje, I., additional, Quiles, L., additional, Pascual, V., additional, Riera, C., additional, Pages, M.A., additional, Godoy, D., additional, Carratalá-Calvo, A., additional, Sánchez-Navarro, S., additional, Valero-Barceló, C., additional, Salaverria, I., additional, Hierro, T. del, additional, Algorta, J., additional, Francisco, S., additional, San Vicente, J., additional, Casi, A., additional, Sanz, E., additional, Felipe, I., additional, Rekondo, J., additional, Loma-Osorio, A., additional, Fernandez-Crehuet, J., additional, Garcia-Rodriguez, A., additional, Wärnberg, J., additional, Benitez Pont, R., additional, Bianchi Alba, M., additional, Navajas, R., additional, Gómez-Huelgas, R., additional, Martínez-González, J., additional, Velasco García, V., additional, de Diego Salas, J., additional, Baca Osorio, A., additional, Gil Zarzosa, J., additional, Sánchez Luque, J.J., additional, Vargas López, E., additional, Romaguera, D., additional, García-Valdueza, M., additional, Proenza, A., additional, Prieto, R., additional, Frontera, G., additional, Munuera, S., additional, Vivó, M., additional, Bestard, F., additional, Munar, J.A., additional, Coll, L., additional, Fiol, F., additional, Ginard, M., additional, Jover, A., additional, García, J., additional, Santos-Lozano, J.M., additional, Ortega-Calvo, M., additional, Leal, M., additional, Martínez, E., additional, Mellado, L., additional, Miró-Moriano, L., additional, Domínguez-Espinaco, C., additional, Vaquero- Diaz, S., additional, Iglesias, P., additional, Román, P., additional, Corchado, Y., additional, Lozano-Rodríguez, J.M., additional, Lamuela-Raventós, R., additional, López- Sabater, M.C., additional, Castellote-Bargalló, A.I., additional, Quifer-Rada, P., additional, Tresserra-Rimbau, A., additional, Alvarez-Pérez, J., additional, Díez Benítez, E., additional, Bautista Castaño, I., additional, Maldonado Díaz, I., additional, Sanchez-Villegas, A., additional, Férnandez- Rodríguez, M.J., additional, Sarmiendo de la Fe, F., additional, Simón García, C., additional, Falcón Sanabria, I., additional, Macías Gutiérrez, B., additional, Santana Santana, A.J., additional, de la Cruz, E., additional, Galera, A., additional, Pintó-Salas, X., additional, Trias, F., additional, Sarasa, I., additional, Rodríguez, M.A., additional, Corbella, X., additional, Corbella, E., additional, Goday, A., additional, Muñoz, M.A., additional, Cabezas, C., additional, Vinyoles, E., additional, Rovira, M.A., additional, Garcia, L., additional, Baby, P., additional, Ramos, A., additional, Mengual, L., additional, Roura, P., additional, Yuste, M.C., additional, Guarner, A., additional, Santamaria, M.I., additional, Mata, M., additional, de Juan, C., additional, Brau, A., additional, Fernandez, M., additional, Gutierrez, E., additional, Murillo, C., additional, Garcia, J., additional, Tafalla, M., additional, Bobe, I., additional, Díaz, A., additional, Araque, M., additional, Solis, E., additional, Cervello, T., additional, Montull, I., additional, Tur, J.A., additional, Portillo, M.P., additional, and Sáez, G., additional

Published
2019
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41. Legume consumption is inversely associated with type 2 diabetes incidence in adults: A prospective assessment from the PREDIMED study

Author

Becerra-Tomás, Nerea, Díaz-López, A., Rosique-Esteban, N., Ros, E., Buil-Cosiales, P., Corella, D., Estruch, R., Fitó, Montserrat, Serra-Majem, L., Arós, F., Lamuela-Raventós, Rosa M., Gueto Rubio, M.V., Loma-Osorio, A., Gómez-Gracia, Enrique, Wärnberg, J., Duaso, I., Rovira, M.A., Benítez Pont, R., Perona, Javier S., Bianchi Alba, M., de la Cruz, E., Basora, J., Brau, A., Salas-Salvadó, J., Bonet, M.T., Gómez-Huelgas, R., Guillén, M., Martínez-González, J., Berrade, N., Molina, C., Casas, Ricard, Sáez, G., Guasch-Ferré, Marta, Iglesias, C., Serra-Mir, M., Velasco García, V., Márquez, F., Montero Romero, Emilio, Vila, J., García-García, M., del Hierro, T., Coltell, O., Jurado-Ruíz, Enrique, Cabré, J.J., Romaguera, D., Valero-Barceló, C., García, M., Costa-Vizcaino, J., Altirriba, J., Prieto, R., García-Valdueza, M., Frontera, G., Fiol, F., Ginard, M., Mestres, G., García, Y., Jover, A., Sorlí, M., Ibarrola-Jurado, Nuria, Molina, N., García, J., Salas-Huetos, A., López-Sabater, M.C., Martínez-Lapiscina, E.H., García Pastor, J.A., Sánchez Luque, J.J., González, J.I., Martín, F., Manzano, E., Fanlo-Maresma, M., Viñas, C., Sáiz, C., Galera, A., Churio-Beraza, B., Trias, F., Bestard, F., Extremera-Urabayen, V., de la Torre, Rafael, Medina-Remón, Alexander, Tort, N., Tello, S., Papandreou, C., Verdú, J.M., Sarasa, I., Muñoz-Aguayo, Daniel, Baby, P., Baena, J.M., Paris, F., Ramos, A., Díaz-Benítez, E.M., Francisco, S., Mengual, L., Ruiz-Canela, M., Roura, P., de Diego Salas, J., Castro Dorado, Antonio, Goñi, E., Fernández-Carrión, R., Fernández-Ballart, J., Yuste, M.C., Aldamiz-Echevarría, M., Alonso-Gómez, A.M., Berjón, J., Sanjulián, B., Montañes, D., Forga, L., Schröder, H., Marrugat, J., Llauradó, M., Giménez, F.J., Gallego, J., Vázquez, Z., García-Layana, A., Moñino, M., Larrauri, A., Vinyoles, E., Rovira, A., Guillem-Saiz, P., Eguaras, S., Simón, C., Oller, M., Salaverria, I., Quinzavos, L., Quifer-Rada, P., Parra, L., de Juan, C., Sarmiento de la Fe, F., Liroz, M., Benavent, J., Castellote-Bargalló, Ana I., Farré, M., Baca Osorio, A., Arroyo-Azpa, C., Altés, A., Clos, J., Cofán, M., Valls-Pedret, C., Sala-Vila, A., Sánchez-Tainta, A., Doménech, M., Portolés, Olga, Algorta, J., Pérez-Cabrera, J., Bulló, M., Gil Zarzosa, J., Babio, N., Corbella, Emili, Maestre, E., Munuera, S., Sanz, E., García-Pérez, L., Pedret, R., Isach, A., Vivó, M., Basells, J., Guarner, A., Vizcaino, J., Martín, M. T., Tresserra-Rimbau, A., Castañer, O., Rekondo, J., Díaz-González, B.V., Ruiz-Gutiérrez, Valentina, Carrasco, P., Segarra, R., Álvarez-Pérez, J., Ortega-Azorín, Carolina, Fiol, Miquel, Asensio, E.M., Martínez, P., Tur, J.A., Osma, R., Castillo Anzalas, J.M., Barragán, R., Portu-Zapirain, J., Alonso-Gómez, A., Corbella, X., Coll, L., González-Monje, I., Francés, F., Quiles, L., Pascual, V., Riera, C., Sosa-Also, R.E., Vargas López, E., Pages, M.A., Casañas-Quintana, L.T., Sánchez-Villegas, A., Pérez-Heras, A., Godoy, D., Cabezas, C., Carratalá-Calvo, A., Pla, I., Sánchez-Navarro, S., Boj, J., Santamaría, M.I., Bautista-Castaño, Inmaculada, Proenza, A., Martí, A., Toledo, E., Mata, M., González, R., SerranoMartínez, M., Sánchez, M.S., Díez-Espino, Javier, Santos-Lozano, J.M., Munar, J.A., Timiraus-Fernández, J., García, L., Villanueva-Tellería, J., García-Arellano, A., Cortés-Ugalde, F., Sagredo-Arce, T., Medina-Ponce, J., Vigata-López, M.D., Elosua, R., García Roselló, J., Arceiz Campo, M.T., Amat, J., Urtasun-Samper, A., Frigola, J., Ruano-Rodríguez, C., Amorós, M., Portillo, María P., Flores-Mateo, Gemma, Belló, M.C., Becerra-Tomás, Nerea, Díaz-López, A., Rosique-Esteban, N., Ros, E., Buil-Cosiales, P., Corella, D., Estruch, R., Fitó, Montserrat, Serra-Majem, L., Arós, F., Lamuela-Raventós, Rosa M., Gueto Rubio, M.V., Loma-Osorio, A., Gómez-Gracia, Enrique, Wärnberg, J., Duaso, I., Rovira, M.A., Benítez Pont, R., Perona, Javier S., Bianchi Alba, M., de la Cruz, E., Basora, J., Brau, A., Salas-Salvadó, J., Bonet, M.T., Gómez-Huelgas, R., Guillén, M., Martínez-González, J., Berrade, N., Molina, C., Casas, Ricard, Sáez, G., Guasch-Ferré, Marta, Iglesias, C., Serra-Mir, M., Velasco García, V., Márquez, F., Montero Romero, Emilio, Vila, J., García-García, M., del Hierro, T., Coltell, O., Jurado-Ruíz, Enrique, Cabré, J.J., Romaguera, D., Valero-Barceló, C., García, M., Costa-Vizcaino, J., Altirriba, J., Prieto, R., García-Valdueza, M., Frontera, G., Fiol, F., Ginard, M., Mestres, G., García, Y., Jover, A., Sorlí, M., Ibarrola-Jurado, Nuria, Molina, N., García, J., Salas-Huetos, A., López-Sabater, M.C., Martínez-Lapiscina, E.H., García Pastor, J.A., Sánchez Luque, J.J., González, J.I., Martín, F., Manzano, E., Fanlo-Maresma, M., Viñas, C., Sáiz, C., Galera, A., Churio-Beraza, B., Trias, F., Bestard, F., Extremera-Urabayen, V., de la Torre, Rafael, Medina-Remón, Alexander, Tort, N., Tello, S., Papandreou, C., Verdú, J.M., Sarasa, I., Muñoz-Aguayo, Daniel, Baby, P., Baena, J.M., Paris, F., Ramos, A., Díaz-Benítez, E.M., Francisco, S., Mengual, L., Ruiz-Canela, M., Roura, P., de Diego Salas, J., Castro Dorado, Antonio, Goñi, E., Fernández-Carrión, R., Fernández-Ballart, J., Yuste, M.C., Aldamiz-Echevarría, M., Alonso-Gómez, A.M., Berjón, J., Sanjulián, B., Montañes, D., Forga, L., Schröder, H., Marrugat, J., Llauradó, M., Giménez, F.J., Gallego, J., Vázquez, Z., García-Layana, A., Moñino, M., Larrauri, A., Vinyoles, E., Rovira, A., Guillem-Saiz, P., Eguaras, S., Simón, C., Oller, M., Salaverria, I., Quinzavos, L., Quifer-Rada, P., Parra, L., de Juan, C., Sarmiento de la Fe, F., Liroz, M., Benavent, J., Castellote-Bargalló, Ana I., Farré, M., Baca Osorio, A., Arroyo-Azpa, C., Altés, A., Clos, J., Cofán, M., Valls-Pedret, C., Sala-Vila, A., Sánchez-Tainta, A., Doménech, M., Portolés, Olga, Algorta, J., Pérez-Cabrera, J., Bulló, M., Gil Zarzosa, J., Babio, N., Corbella, Emili, Maestre, E., Munuera, S., Sanz, E., García-Pérez, L., Pedret, R., Isach, A., Vivó, M., Basells, J., Guarner, A., Vizcaino, J., Martín, M. T., Tresserra-Rimbau, A., Castañer, O., Rekondo, J., Díaz-González, B.V., Ruiz-Gutiérrez, Valentina, Carrasco, P., Segarra, R., Álvarez-Pérez, J., Ortega-Azorín, Carolina, Fiol, Miquel, Asensio, E.M., Martínez, P., Tur, J.A., Osma, R., Castillo Anzalas, J.M., Barragán, R., Portu-Zapirain, J., Alonso-Gómez, A., Corbella, X., Coll, L., González-Monje, I., Francés, F., Quiles, L., Pascual, V., Riera, C., Sosa-Also, R.E., Vargas López, E., Pages, M.A., Casañas-Quintana, L.T., Sánchez-Villegas, A., Pérez-Heras, A., Godoy, D., Cabezas, C., Carratalá-Calvo, A., Pla, I., Sánchez-Navarro, S., Boj, J., Santamaría, M.I., Bautista-Castaño, Inmaculada, Proenza, A., Martí, A., Toledo, E., Mata, M., González, R., SerranoMartínez, M., Sánchez, M.S., Díez-Espino, Javier, Santos-Lozano, J.M., Munar, J.A., Timiraus-Fernández, J., García, L., Villanueva-Tellería, J., García-Arellano, A., Cortés-Ugalde, F., Sagredo-Arce, T., Medina-Ponce, J., Vigata-López, M.D., Elosua, R., García Roselló, J., Arceiz Campo, M.T., Amat, J., Urtasun-Samper, A., Frigola, J., Ruano-Rodríguez, C., Amorós, M., Portillo, María P., Flores-Mateo, Gemma, and Belló, M.C.

Abstract

Background & aims: Legumes, a low-energy, nutrient-dense and low glycemic index food, have shown beneficial effects on glycemic control and adiposity. As such, legumes are widely recommended in diabetic diets, even though there is little evidence that their consumption protects against type 2 diabetes. Therefore the aim of the present study was to examine the associations between consumption of total legumes and specific subtypes, and type 2 diabetes risk. We also investigated the effect of theoretically substituting legumes for other protein- or carbohydrate-rich foods. Methods: Prospective assessment of 3349 participants in the PREvención con DIeta MEDiterránea (PREDIMED) study without type 2 diabetes at baseline. Dietary information was assessed at baseline and yearly during follow-up. We used Cox regression models to estimate hazard ratios (HRs) and 95% confidence intervals (95% CIs) for type-2 diabetes incidence according to quartiles of cumulative average consumption of total legumes, lentils, chickpeas, dry beans and fresh peas. Results: During a median follow-up of 4.3 years, 266 new cases of type 2 diabetes occurred. Individuals in the highest quartile of total legume and lentil consumption had a lower risk of diabetes than those in the lowest quartile (HR: 0.65; 95% CI: 0.43, 0.96; P-trend = 0.04; and HR: 0.67; 95% CI: 0.46–0.98; P-trend = 0.05, respectively). A borderline significant association was also observed for chickpeas consumption (HR 0.68; 95% CI: 0.46, 1.00; P-trend = 0.06). Substitutions of half a serving/day of legumes for similar servings of eggs, bread, rice or baked potato was associated with lower risk of diabetes incidence. Conclusions: A frequent consumption of legumes, particularly lentils, in the context of a Mediterranean diet, may provide benefits on type 2 diabetes prevention in older adults at high cardiovascular risk. Trial registration: The trial is registered at http://www.controlled-trials.com (ISRCTN35739639). Registration dat

Published
2018

42. Long-chain n-3 PUFA supplied by the usual diet decrease plasma stearoyl-CoA desaturase index in non-hypertriglyceridemic older adults at high vascular risk

Author

Universitat Rovira i Virgili, Pérez-Heras A., Mayneris-Perxachs J., Cofán M., Serra-Mir M., Castellote A., López-Sabater C., Fitó M., Salas-Salvadó J., Martínez-González M., Corella D., Estruch R., Ros E., Sala-Vila A., Universitat Rovira i Virgili, and Pérez-Heras A., Mayneris-Perxachs J., Cofán M., Serra-Mir M., Castellote A., López-Sabater C., Fitó M., Salas-Salvadó J., Martínez-González M., Corella D., Estruch R., Ros E., Sala-Vila A.

Abstract

The activity of stearoyl-CoA desaturase-1 (SCD1), the central enzyme in the synthesis of monounsaturated fatty acids (MUFA), has been associated with de novo lipogenesis. In experimental models SCD1 is down-regulated by polyunsaturated fatty acids (PUFA), but clinical studies are scarce. The effect of long-chain n-3 PUFA (LCn-3PUFA) supplied by the regular diet, in the absence of fatty fish or fish oil supplementation, remains to be explored.We related 1-y changes in plasma SCD1 index, as assessed by the C16:1n-7/C16:0 ratio, to both adiposity traits and nutrient intake changes in a sub-cohort (n = 243) of non-hypertriglyceridemic subjects of the PREDIMED (PREvención con DIeta MEDiterranea) trial.After adjustment for confounders, including changes in fasting triglycerides, plasma SCD1 index increased in parallel with body weight (0.221 [95% confidence interval, 0.021 to 0.422], P = 0.031) and BMI (0.115 [0.027 to 0.202], P = 0.011). Additionally, dietary LCn-3PUFA (but not MUFA or plant-derived PUFA) were associated with decreased plasma SCD1 index (-0.544 [-1.044 to -0.043], P = 0.033, for each 1 g/d-increase in LCn-3PUFA). No associations were found for other food groups, but there was a trend for fatty fish intake (-0.083 [-0.177 to 0.012], P = 0.085, for each 10 g/d-increase).Our data add clinical evidence on the down-regulation of plasma SCD1 index by LCn-3PUFA in the context of realistic changes in fish consumption in the customary, non-supplemented diet.http://www.Controlled-trials.com/ISRCTN35739639.Copyright © 2016 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.

Published
2018

43. Potato consumption does not increase blood pressure or incident hypertension in 2 cohorts of Spanish adults

Author

Hu, E.A., Martínez-González, Miguel Ángel, Salas-Salvadó, J., Corella, D., Ros, E., Fitó, Montserrat, García-Rodriguez, A., Estruch, R., Arós, F., Fiol, M., Lapetra, José, Tresserra-Rimbau, A., Amat, J., García Roselló, J., Sanchez-Villegas, A., Álvarez-Pérez, J., Amorós, M., Cervello, T., Díez Benítez, E., Rovira, M.A., Altirriba, J., Sáiz, C., Mata, M., Bautista-Castaño, Inmaculada, Maldonado Díaz, I., Fernández-Rodríguez, M. J., Duaso, I., Becerra-Tomás, Nerea, Trias, F., García, L., Brau, A., Sáez, G., Corbella, E., de Diego Salas, J., Fernández-Montero, A., Yuste, M.C., Prieto, R., Pérez-de-Ciriza, P., Bobe, I., Navajas, Sánchez-Ruiz, D., Schröder, H., Jurado-Ruiz, E., Portillo, M.P., Buil-Cosiales, P., Sarmiendo de la Fe, F., Sánchez Luque, J.J., Ferreira, C., Zazpe, I., Díez-Espino, Javier, Sarasa, I., Sanjulian, B., Marti, A., Sorlí, J.V., Portolés, O., Martínez, J. Alfredo, Baby, P., Ibarrola-Jurado, Nuria, Serrano-Martínez, M., Sánchez-Tainta, A., Fernández-Crehuet, Joaquín, Pascual, V., García-Arellano, A., Fernandez, M., Paris, F., Giménez, F.J., Basteara-Gortari, J., Extremera-Urabayen, J.V., Benítez Pont, R., Viñas, C., Algorta, J., Garcia-Pérez, L., Serra-Majem, L., Bonet, M.T., Riera, C., Arroyo-Azpa, C., Guarner, A., Sola-Larraza, A., Barcena, F., García, Y., Gutiérrez-Bedmar, M., Casas, R., Oreja-Arrayago, C., Lasanta-Sáez, M.J., Mena, G., Francisco, S., Cia-Lecumberri, P., García-Valdueza, M., Diáz, A., Elcarte-Lopez, T., Artal-Moneva, F., Martín, M.T., Vargas López, E., Medina-Remón, A., Iglesias, C., Esparza-López, J.M., Figuerido-Garmendia, E., Cabre, M., Coltell, O., Wärnberg, J., Tabar-Sarrias, J.A., Pages, M.A., Rebholz, C.M., Fernández-Urzainqui, L., Ariz-Arnedo, M.J., San Vicente, J., Martínez, P., Cabeza-Beunza, J.A., Simón, C., Rekondo, J., Sánchez, M.S., Pascual-Pascual, P., Martínez-Mazo, M.D., Arina-Vergara, E., Godoy, D., Ruiz-Gutiérrez, Valentina, Villanueva, P., Quinzavos, L., Manzano, E., Martin, F., de Juan, C., Basells, J., Pla, I., Tur, J.A., Vizcaino, J., Basora-Gallisa, J., Núñez-Córdoba, J.M., Segarra, R., Hernández, P., Araque, M., Giardina, S., Macua-Martínez, T., Gutierrez, E., Toledo, E., Pedret, R., Guasch-Ferré, Marta, Baena, J.M., Pintó, Xavier, Díaz-López, A., Rosique-Esteban, N., Fernández-Ballart, J., Parra, L., Velasco García, V., Balanza, R., Tello, S., Ramos, A., Simón García, C., Vila, J., Altés, A., Proenza, A., de la Torre, Rafael, Muñoz-Aguayo, D., Murillo, C., Fernández-Carrión, R., Rodríguez, M.A., Elosua, R., Tort, N., Casi, A., Falcón Sanabria, I., Marrugat, J., Ruiz-Canela, M., Carratalá-Calvo, A., Mengual, L., Guillem-Saiz, P., Molina, N., Maestre, E., Gómez-Huelgas, R., Corbella, X., Rovira, A., González, R., Castañer, O., Farré, M., Sanz, E., García, J., González-Monje, I., Sánchez-Navarro, S., Carrasco, P., Ortega-Azorín, C., Romaguera, D., Roura, P., Asensio, E.M., Vázquez-Ruiz, Z., Canudas, S., Osma, R., Barragán, R., Muñoz, M.A., Martínez-González, J., Razquin, C., Valero-Barceló, C., Felipe, I., Francés, F., Guillén, M., González, J.I., Macías Gutiérrez, B., Tafalla, M., Bulló, M., Salaverria, I., Loma-Osorio, A., Baca Osorio, A., Munuera, S., Alonso, A., Sorlí, J., Vivó, M., Benitez Pont, R., Llauradó, M., Bestard, F., Montero Romero, Emilio, Molina, C., Munar, J.A., Cofán, M., Papandreou, C., Frontera, G., Coll, L., Quiles, L., Isach, A., Bes-Rastrollo, M., Perona, Javier S., Fiol, F., del Hierro, T., Ginard, M., Jover, A., Liroz, M., Parra-Osés, A., Gómez-Gracia, Enrique, Montull, I., Santos-Lozano, J.M., Ortega-Calvo, M., Valls-Pedret, C., García, M., Leal, M., Gil Zarzosa, J., Rico, A., Serra-Mir, M., Martínez, E., Mellado, L., Babio, N., Santana Santana, A.J., Benavent, J., Miró-Moriano, L., De la Fuente-Arrillaga, C., Oller, M., Domínguez-Espinaco, C., Bianchi Alba, M., Vaquero-Diaz, S., Iglesias, P., Cabezas, C., Sala-Vila, A., de la Cruz, E., Román, P., Corchado, Y., Solis, E., Clos, J., Lozano-Rodríguez, J.M., Mestres, G., García-García, M., Lamuela-Raventós, Rosa M., López-Sabater, M.C., Santamaria, M.I., Salas-Huetos, A., Galera, A., Vinyoles, E., Castellote-Bargalló, A. I., Quifer-Rada, P., Gea, A., Pérez-Heras, A., Doménech, M., Instituto de Salud Carlos III, Ministerio de Ciencia e Innovación (España), and Junta de Andalucía

Subjects
Adult, Male, Pediatrics, medicine.medical_specialty, Diastole, Medicine (miscellaneous), 030204 cardiovascular system & hematology, Mediterranean, 03 medical and health sciences, 0302 clinical medicine, Animal science, Glycemic load, SUN cohort, medicine, Humans, 030212 general & internal medicine, Intervention trial, Prospective cohort study, Potatoes, Generalized estimating equation, Aged, Solanum tuberosum, Aged, 80 and over, Nutrition and Dietetics, Increase blood pressure, business.industry, Incidence (epidemiology), PREDIMED study, Middle Aged, Diet, Blood pressure, Spain, Hypertension, Female, business
Abstract

5 Tablas, Background: Potatoes have a high glycemic load but also antioxidants, vitamins, and minerals. It is unclear what mechanisms are involved in relation to their effect on blood pressure (BP) and hypertension. Objectives: This study aimed to assess the association between potato consumption, BP changes, and the risk of hypertension in 2 Spanish populations. Methods: Separate analyses were performed in PREDIMED (PREvención con DIeta MEDiterránea), a multicenter nutrition intervention trial of adults aged 55-80 y, and the SUN (Seguimiento Universidad de Navarra) project, a prospective cohort made up of university graduates and educated adults with ages (means±SDs) of 42.7±13.3 y for men and 35.1± 10.7 y for women. In PREDIMED, generalized estimating equations adjusted for lifestyle and dietary characteristics were used to assess changes in BP across quintiles of total potato consumption during a 4-y follow-up. Controlled BP values (systolic BP < 140 mm Hg and diastolic BP < 90 mm Hg) during follow-up were also assessed. For SUN, multivariateadjusted HRs for incident hypertension during a mean 6.7-y follow-up were calculated. Results: In PREDIMED, the total potato intake was 81.9 ± 40.6 g/d. No overall differences in systolic or diastolic BP changes were detected based on consumption of potatoes. For total potatoes, the mean difference in change between quintile 5 (highest intake) and quintile 1 (lowest intake) in systolic BP after multivariate adjustment was 20.90 mm Hg (95% CI: -2.56, 0.76 mm Hg; P-trend = 0.1) and for diastolic BP was 20.02 mm Hg (95% CI: -0.93, 0.89 mm Hg; P-trend = 0.8). In SUN, the total potato consumption was 52.7 ± 33.6 g/d, and no significant association between potato consumption and hypertension incidence was observed in the fully adjusted HR for total potato consumption (quintile 5 compared with quintile 1: 0.98; 95% CI: 0.80, 1.19; P-trend = 0.8). Conclusions: Potato consumption is not associated with changes over 4 y in blood pressure among older adults in Spain or with the risk of hypertension among Spanish adults., Supported by the official funding agency for biomedical research of the Spanish Government, Instituto de Salud Carlos III through grants provided to research networks specifically developed for the trial (RTIC G03/140, to RE; RTIC RD 06/0045, to MAM-G) and through Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición (CIBERobn), and by grants from Centro Nacional de Investigaciones Cardiovasculares (CNIC 06/2007), Fondo de Investigación Sanitaria–Fondo Europeo de Desarrollo Regional [Proyecto de Investigación (PI) 04-2239, PI 05/2584, CP06/00100, PI07/0240, PI07/1138, PI07/0954, PI 07/0473, PI10/01407, PI10/02658, PI11/01647, P11/02505 and PI13/00462], Ministerio de Ciencia e Innovación [Recursos y teconologia agroalimentarias (AGL)-2009-13906-C02 and AGL2010-22319-C03 and AGL2013-49083-C3-1-R], Fundación Mapfre 2010, the Consejería de Salud de la Junta de Andalucía (PI0105/2007), the Public Health Division of the Department of Health of the Autonomous Government of Catalonia, Generalitat Valenciana [Generalitat Valenciana Ayuda Complementaria (GVACOMP) 06109, GVACOMP2010-181, GVACOMP2011-151], Conselleria de Sanitat y AP; Atención Primaria (CS) 2010-AP-111 and CS2011-AP-042, and Regional Government of Navarra (P27/2011).

Published
2017

44. Prediction of cardiovascular disease by the framingham-REGICOR equation in the high-risk PREDIMED cohort: Impact of the mediterranean diet across different risk strata

Author

Antonio J. Amor, Mercè Serra‐Mir, Miguel A. Martínez‐González, Dolores Corella, Jordi Salas‐Salvadó, Montserrat Fitó, Ramón Estruch, Lluis Serra‐Majem, Fernando Arós, Nancy Babio, Emilio Ros, Emilio Ortega, A. Pérez‐Heras, C. Viñas, R. Casas, L. de Santamaría, S. Romero, E. Sacanella, G. Chiva, P. Valderas, S. Arranz, J. M. Baena, M. García, M. Oller, J. Amat, I. Duaso, Y. García, C. Iglesias, C. Simón, Ll. Quinzavos, Ll. Parra, M. Liroz, J. Benavent, J. Clos, I. Pla, M. Amorós, M. T. Bonet, M. T. Martin, M. S. Sánchez, J. Altirriba, E. Manzano, A. Altés, A. Sala‐Vila, M. Cofán, C. Valls‐Pedret, T. M. Freitas‐Simoes, M. Doménech, R. Gilabert, N. Bargalló, M. Bulló, J. Basora, R. González, A. Díaz‐López, C. Molina, G. Mena, F. Márquez, P. Martínez, N. Ibarrola, M. Sorli, J. García Roselló, F. Martín, N. Tort, A. Isach, A. Salas‐Huetos, N. Becerra‐Tomás, N. Rosique Esteban, J. J. Cabré, G. Mestres, F. Paris, M. Llaurado, R. Pedret, J. Basells, J. Vizcaino, R. Segarra, P. Hernandez‐Alonso, S. Giardina, C. Ferreira‐Pego, C. Papandreou, L. Camacho, E. Toledo, P. Buil‐Cosiales, M. Ruiz‐Canela, J. A. Martínez, B. Sanjulian, A. Sánchez‐Tainta, J. Diez‐Espino, C. Razquin, A. Garcia‐Arellano, E. Goni, Z. Vazquez, N. Berrade, V. Extremera‐Urabayen, S. Eguaras, A. Marti, C. Arroyo‐Azpa, L. García‐Pérez, J. Villanueva Telleria, F. Cortés Ugalde, T. Sagredo Arce, M. D. García de la Noceda Montoy, M. D. Vigata López, M. T. Arceiz Campo, A. Urtasun Samper, M. V. Gueto Rubio, A. Sola, N. Goñi, O. Lecea, S. Tello, J. Vila, R. de la Torre, D. Muñoz‐Aguayo, R. Elosua, J. Marrugat, H. Schröder, N. Molina, E. Maestre, O. Castañer, A. Rovira, M. Farre, J. V. Sorli, V. Zanon‐Moreno, P. Carrasco, C. Ortega‐Azorín, E. M. Asensio, R. Osma, R. Barragán, F. Francés, M. Guillén, J. I. González, C. Saiz, O. Portolés, F. J. Giménez, O. Coltell, P. Guillem‐Saiz, L. Quiles, V. Pascual, C. Riera, M. A. Pages, D. Godoy, A. Carratala‐Calvo, M. J. Martín‐Rillo, E. Llopis‐Osorio, J. Ruiz‐Baixauli, A. Bertolín‐Muñoz, I. Salaverría, T. del Hierro, J. Algorta, S. Francisco, A. Alonso‐Gómez, E. Sanz, J. Rekondo, M. C. Bello, A. Loma‐Osorio, E. Gómez‐Gracia, J. Warnberg, R. Benítez Pont, M. Bianchi Alba, R. Gómez‐Huelgas, J. Martínez‐González, V. Velasco García, J. de Diego Salas, A. Baca Osorio, J. Gil Zarzosa, J. J. Sánchez Luque, E. Vargas López, V. Ruiz‐Gutiérrez, J. Sánchez Perona, E. Montero Romero, M. García‐García, E. Jurado‐Ruiz, M. Fiol, M. García‐Valdueza, M. Moñino, A. Proenza, R. Prieto, G. Frontera, M. Ginard, F. Fiol, A. Jover, D. Romaguera, J. García, J. Lapetra, J. M. Santos‐Lozano, M. Ortega‐Calvo, L. Mellado, M. Leal, E. Martínez, F. José García, P. Román, P. Iglesias, Y. Corchado, L. Miró, C. Domínguez, J. M. Lozano, E. Mayoral, R. M. Lamuela‐Raventós, M. C. López‐Sabater, A. I. Castellote‐Bargallo, A. Tresserra‐Rimbau, J. Álvarez‐Pérez, E. M. Díaz‐Benítez, I. Bautista Castaño, A. Sánchez‐Villegas, M. J. Fernández‐Rodríguez, T. Casanas Quintana, J. Pérez‐Cabrera, M. Nissensohn, V. Díaz‐González, C. Ruano‐Rodríguez, A. P. Ortiz‐Andrelluchi, B. Macías Gutiérrez, A. J. Santana‐Santana, X. Pintó, E. de la Cruz, A. Galera, Y. Soler, F. Trias, I. Sarasa, E. Padres, E. Corbella, C. Cabezas, E. Vinyoles, M. A. Rovira, L. García, G. Flores, J. M. Verdú, P. Baby, A. Ramos, L. Mengual, P. Roura, M. C. Yuste, A. Guarner, M. I. Santamaría, M. Mata, C. de Juan, A. Brau, J. A. Tur, M. P. Portillo, G. Sáez, M. Aldamiz, A. Alonso, J. Berjón, L. Forga, J. Gallego, A. Larrauri, J. Portu, J. Timiraos, M. Serrano‐Martínez, Instituto de Salud Carlos III, Centro Nacional de Investigaciones Cardiovasculares (España), Ministerio de Ciencia e Innovación (España), and California Walnut Commission

Subjects
Male, Mediterranean diet, Epidemiology, Disease, 030204 cardiovascular system & hematology, Diet, Mediterranean, Cohort Studies, 0302 clinical medicine, Risk Factors, Medicine, 030212 general & internal medicine, Risk assessment, Original Research, Diet and Nutrition, Aged, 80 and over, Framingham Risk Score, Diabetis, Diabetes, Middle Aged, Prognosis, Cardiovascular disease, Primary Prevention, Cardiovascular diseases, Cardiovascular Diseases, Cohort, Female, Cardiology and Cardiovascular Medicine, Framingham‐REGICOR equation, PREDIMED, Cardiovascular risk prediction, Scale (ratio), Risk Assessment, 03 medical and health sciences, Humans, cardiovascular diseases, Aged, Proportional Hazards Models, Framingham-REGICOR equation, business.industry, Malalties cardiovasculars, Feeding Behavior, Lifestyle, Predimed, Diabetes Mellitus, Type 2, Spain, Avaluació del risc, Mediterraneam diet, business, Demography
Abstract

Background-The usefulness of cardiovascular disease (CVD) predictive equations in different populations is debatable. We assessed the efficacy of the Framingham-REGICOR scale, validated for the Spanish population, to identify future CVD in participants, who were predefined as being at high-risk in the PREvención con DIeta MEDiterránea (PREDIMED) study-a nutrition-intervention primary prevention trial-and the impact of adherence to the Mediterranean diet on CVD across risk categories. Methods and Results-In a post hoc analysis, we assessed the CVD predictive value of baseline estimated risk in 5966 PREDIMED participants (aged 55-74 years, 57% women; 48% with type 2 diabetes mellitus). Major CVD events, the primary PREDIMED end point, were an aggregate of myocardial infarction, stroke, and cardiovascular death. Multivariate-adjusted Cox regression was used to calculate hazard ratios for major CVD events and effect modification from the Mediterranean diet intervention across risk strata (low, moderate, high, very high). The Framingham-REGICOR classification of PREDIMED participants was 25.1% low risk, 44.5% moderate risk, and 30.4% high or very high risk. During 6-year follow-up, 188 major CVD events occurred. Hazard ratios for major CVD events increased in parallel with estimated risk (2.68, 4.24, and 6.60 for moderate, high, and very high risk), particularly in men (7.60, 13.16, and 15.85, respectively, versus 2.16, 2.28, and 3.51, respectively, in women). Yet among those with low or moderate risk, 32.2% and 74.3% of major CVD events occurred in men and women, respectively. Mediterranean diet adherence was associated with CVD risk reduction regardless of risk strata (P > 0.4 for interaction). Conclusions-Incident CVD increased in parallel with estimated risk in the PREDIMED cohort, but most events occurred in non- high-risk categories, particularly in women. Until predictive tools are improved, promotion of the Mediterranean diet might be useful to reduce CVD independent of baseline risk., This study was funded in part by Instituto de Salud Carlos III (ISCIII) (Spanish Ministry of Economy) through grants RTIC G03/140, RTIC RD 06/0045, Centro Nacional de Investigaciones Cardiovasculares CNIC 06/2007, ISCIII FIS PS09/01292, the Spanish Ministry of Science and Innovation (MICINN) AGL2010‐22319‐C03‐02 and AGL2009‐13906‐C02‐02, and an unrestricted grant from the California Walnut Commission

Published
2017

46. El mapa automático: innovación pública para la generación del Mapa Topográfico Nacional.

Author

Boluda Sánchez, Alfonso, Maldonado Ibáñez, Ana, Pérez Heras, Adolfo, Quesada Bustos, Felisa, De Tomás Gargantilla, José Alfonso, Navas López, Maria Paz, Prieto Del Caño, Santiago, and González Jiménez, Alicia

Subjects
TOPOGRAPHIC maps, CARTOGRAPHY, INFORMATION services, MAPS, COMPUTERS
Abstract

Copyright of Mapping (1131-9100) is the property of eGeoMapping S.L. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2020

47. Legume consumption is inversely associated with type 2 diabetes incidence in adults: A prospective assessment from the PREDIMED study

Author

Becerra-Tomás, Nerea, primary, Díaz-López, Andrés, additional, Rosique-Esteban, Núria, additional, Ros, Emilio, additional, Buil-Cosiales, Pilar, additional, Corella, Dolores, additional, Estruch, Ramon, additional, Fitó, Montserrat, additional, Serra-Majem, Lluís, additional, Arós, Fernando, additional, Lamuela-Raventós, Rosa Maria, additional, Fiol, Miquel, additional, Santos-Lozano, José Manuel, additional, Díez-Espino, Javier, additional, Portoles, Olga, additional, Salas-Salvadó, Jordi, additional, Serra-Mir, M., additional, Pérez-Heras, A., additional, Viñas, C., additional, Casas, R., additional, Medina-Renom, A., additional, Baena, J.M., additional, García, M., additional, Oller, M., additional, Amat, J., additional, Duaso, I., additional, García, Y., additional, Iglesias, C., additional, Simón, C., additional, Quinzavos, L., additional, Parra, L., additional, Liroz, M., additional, Benavent, J., additional, Clos, J., additional, Pla, I., additional, Amorós, M., additional, Bonet, M.T., additional, Martín, M.T., additional, Sánchez, M.S., additional, Altirriba, J., additional, Manzano, E., additional, Altés, A., additional, Cofán, M., additional, Valls-Pedret, C., additional, Sala-Vila, A., additional, Doménech, M., additional, Bulló, M., additional, Babio, N., additional, Basora, J., additional, González, R., additional, Molina, C., additional, Márquez, F., additional, Martínez, P., additional, Ibarrola, N., additional, Sorlí, M., additional, García Roselló, J., additional, Castro, A., additional, Martin, F., additional, Tort, N., additional, Isach, A., additional, Guasch-Ferre, M., additional, Cabré, J.J., additional, Mestres, G., additional, Paris, F., additional, Llauradó, M., additional, Pedret, R., additional, Basells, J., additional, Vizcaino, J., additional, Segarra, R., additional, Frigola, J., additional, Costa-Vizcaino, J., additional, Salas-Huetos, A., additional, Boj, J., additional, Montañes, D., additional, Papandreou, Christopher, additional, Fernández-Ballart, J., additional, Carrasco, P., additional, Ortega-Azorín, C., additional, Asensio, E.M., additional, Osma, R., additional, Barragán, R., additional, Francés, F., additional, Guillén, M., additional, González, J.I., additional, Sáiz, C., additional, Portolés, O., additional, Giménez, F.J., additional, Coltell, O., additional, Fernández-Carrión, R., additional, Guillem-Sáiz, P., additional, González-Monje, I., additional, Quiles, L., additional, Pascual, V., additional, Riera, C., additional, Pages, M.A., additional, Godoy, D., additional, Carratalá-Calvo, A., additional, Sánchez-Navarro, S., additional, Valero-Barceló, C., additional, Tello, S., additional, Vila, J., additional, de la Torre, R., additional, Muñoz-Aguayo, D., additional, Elosua, R., additional, Marrugat, J., additional, Schröder, H., additional, Molina, N., additional, Maestre, E., additional, Rovira, A., additional, Castañer, O., additional, Farré, M., additional, Toledo, E., additional, Ruiz-Canela, M., additional, Sanjulián, B., additional, Sánchez-Tainta, A., additional, Eguaras, S., additional, Martí, A., additional, Buil-Cosiales, P., additional, SerranoMartínez, M., additional, Diez-Espino, J., additional, García-Arellano, A., additional, Martínez-Lapiscina, E.H., additional, Goñi, E., additional, Vázquez, Z., additional, Berrade, N., additional, Extremera-Urabayen, V., additional, Arroyo-Azpa, C., additional, García-Pérez, L., additional, Villanueva-Telleria, J., additional, Cortés-Ugalde, F., additional, Sagredo-Arce, T., additional, Vigata-López, M.D., additional, Arceiz Campo, M.T., additional, Urtasun-Samper, A., additional, Gueto Rubio, M.V., additional, Churio-Beraza, B., additional, Arós, F., additional, Salaverria, I., additional, del Hierro, T., additional, Algorta, J., additional, Francisco, S., additional, Alonso-Gómez, A., additional, Sanz, E., additional, Rekondo, J., additional, Belló, M.C., additional, Loma-Osorio, A., additional, Gómez-Gracia, E., additional, Wärnberg, J., additional, Benítez Pont, R., additional, Bianchi Alba, M., additional, Gómez-Huelgas, R., additional, Martínez-González, J., additional, Velasco García, V., additional, de Diego Salas, J., additional, Baca Osorio, A., additional, Gil Zarzosa, J., additional, Sánchez Luque, J.J., additional, Vargas López, E., additional, Ruiz-Gutiérrez, V., additional, Sánchez Perona, J., additional, Montero Romero, E., additional, García-García, M., additional, Jurado-Ruiz, E., additional, Fiol, M., additional, Romaguera, D., additional, García-Valdueza, M., additional, Moñino, M., additional, Munuera, S., additional, Vivó, M., additional, Bestard, F., additional, Munar, J.A., additional, Coll, L., additional, Proenza, A., additional, Prieto, R., additional, Frontera, G., additional, Fiol, F., additional, Ginard, M., additional, Jover, A., additional, García, J., additional, Santos-Lozano, J.M., additional, Ortega-Calvo, M., additional, Mellado, L., additional, García-Corte, F.J., additional, Román, P., additional, Iglesias, P., additional, Corchado, Y., additional, Miró-Moriano, L., additional, Domínguez-Espinaco, C., additional, Lozano-Rodriguez, J.M., additional, Vaquero-Diaz, S., additional, López- Sabater, M.C., additional, Castellote-Bargalló, A.I., additional, Quifer-Rada, P., additional, Tresserra-Rimbau, A., additional, Álvarez-Pérez, J., additional, Díaz-Benítez, E.M., additional, Sánchez-Villegas, A., additional, Casañas-Quintana, L.T., additional, Pérez-Cabrera, J., additional, Ruano-Rodríguez, C., additional, Bautista-Castaño, I., additional, Sarmiento de la Fe, F., additional, García Pastor, J.A., additional, Díaz-González, B.V., additional, Castillo Anzalas, J.M., additional, Sosa-Also, R.E., additional, Medina-Ponce, J., additional, de la Cruz, E., additional, Fanlo-Maresma, M., additional, Galera, A., additional, Trias, F., additional, Sarasa, I., additional, Corbella, E., additional, Corbella, X., additional, Cabezas, C., additional, Vinyoles, E., additional, Rovira, M.A., additional, García, L., additional, Flores, G., additional, Verdú, J.M., additional, Baby, P., additional, Ramos, A., additional, Mengual, L., additional, Roura, P., additional, Yuste, M.C., additional, Guarner, A., additional, Santamaría, M.I., additional, Mata, M., additional, de Juan, C., additional, Brau, A., additional, Tur, J.A., additional, Portillo, M.P., additional, Sáez, G., additional, Aldamiz-Echevarría, M., additional, Alonso-Gómez, A.M., additional, Berjón, J., additional, Forga, L., additional, Gállego, J., additional, García-Layana, A., additional, Larrauri, A., additional, Portu-Zapirain, J., additional, and Timiraus-Fernández, J., additional

Published
2018
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48. Potato consumption does not increase blood pressure or incident hypertension in 2 cohorts of Spanish adults

Author

Instituto de Salud Carlos III, Ministerio de Ciencia e Innovación (España), Junta de Andalucía, Hu, E.A., Martínez-González, Miguel Ángel, Salas-Salvadó, J., Corella, D., Ros, E., Fitó, Montserrat, García-Rodriguez, A., Estruch, R., Arós, F., Fiol, M., Lapetra, José, Asensio, E.M., Vázquez-Ruiz, Z., Canudas, S., Osma, R., Barragán, R., Muñoz, M.A., Martínez-González, J., Razquin, C., Valero-Barceló, C., Rovira, M.A., Tabar-Sarrias, J.A., Felipe, I., Francés, F., Guillén, M., González, J.I., Macías Gutiérrez, B., Tafalla, M., Bulló, M., Salaverria, I., Loma-Osorio, A., Baca Osorio, A., Pages, M.A., Altirriba, J., Munuera, S., Alonso, A., Sorlí, J., Vivó, M., Benitez Pont, R., Llauradó, M., Bestard, F., Montero Romero, Emilio, Molina, C., Rebholz, C.M., Munar, J.A., Sáiz, C., Cofán, M., Papandreou, C., Frontera, G., Coll, L., Quiles, L., Isach, A., Bes-Rastrollo, M., Perona, Javier S., Fernández-Urzainqui, L., Fiol, F., del Hierro, T., Mata, M., Ginard, M., Jover, A., Liroz, M., Parra-Osés, A., García, J., Gómez-Gracia, Enrique, Montull, I., Ariz-Arnedo, M.J., Santos-Lozano, J.M., Ortega-Calvo, M., Valls-Pedret, C., Bautista-Castaño, Inmaculada, García, M., Leal, M., Gil Zarzosa, J., Rico, A., Serra-Mir, M., Martínez, E., San Vicente, J., Mellado, L., Babio, N., Santana Santana, A.J., Benavent, J., Maldonado Díaz, I., Miró-Moriano, L., De la Fuente-Arrillaga, C., Rovira, A., Oller, M., Domínguez-Espinaco, C., Martínez, P., Bianchi Alba, M., Vaquero-Diaz, S., Iglesias, P., Cabezas, C., Sala-Vila, A., Fernández-Rodríguez, M. J., de la Cruz, E., Román, P., Corchado, Y., Solis, E., Cabeza-Beunza, J.A., Clos, J., Lozano-Rodríguez, J.M., Mestres, G., García-García, M., Lamuela-Raventós, Rosa M., López-Sabater, M.C., Duaso, I., Santamaria, M.I., Salas-Huetos, A., Galera, A., Simón, C., Vinyoles, E., Castellote-Bargalló, Ana I., Quifer-Rada, P., Gea, A., Pérez-Heras, A., Doménech, M., Becerra-Tomás, Nerea, Trias, F., García, L., Brau, A., Rekondo, J., Sáez, G., Corbella, Emili, de Diego Salas, J., Fernández-Montero, A., Yuste, M.C., Prieto, R., Pérez-de-Ciriza, P., Bobe, I., Navajas, R., Sánchez-Ruiz, D., Tresserra-Rimbau, A., Schröder, H., Jurado-Ruíz, Enrique, Portillo, María P., Buil-Cosiales, P., Sarmiendo de la Fe, F., Sánchez Luque, J.J., Ferreira, C., Zazpe, I., Díez-Espino, Javier, Sarasa, I., Sánchez, M.S., Sanjulian, B., Marti, A., Sorlí, J.V., Portolés, Olga, Martínez, J. Alfredo, Baby, P., Ibarrola-Jurado, Nuria, Serrano-Martínez, M., Sánchez-Tainta, A., Fernández-Crehuet, Joaquín, Pascual-Pascual, P., Pascual, V., García-Arellano, A., Fernández, M., Paris, F., Giménez, F.J., Basteara-Gortari, J., Extremera-Urabayen, J.V., Benítez Pont, R., Viñas, C., Algorta, J., Martínez-Mazo, M.D., Garcia-Pérez, L., Serra-Majem, L., Bonet, M.T., Riera, C., Arroyo-Azpa, C., Guarner, A., Sola-Larraza, A., Barcena, F., García, Y., Gutiérrez-Bedmar, M., Arina-Vergara, E., Casas, Ricard, Oreja-Arrayago, C., Lasanta-Sáez, M.J., Mena, G., Francisco, S., Cia-Lecumberri, P., García-Valdueza, M., Diáz, A., Elcarte-Lopez, T., Artal-Moneva, F., Godoy, D., Martín, M. T., Vargas López, E., Medina-Remón, Alexander, Iglesias, C., Esparza-López, J.M., Figuerido-Garmendia, E., Cabre, M., Coltell, O., Wärnberg, J., Ruiz-Gutiérrez, Valentina, Villanueva, P., Quinzavos, L., Manzano, E., Martín, F., Amat, J., de Juan, C., Basells, J., Pla, I., Tur, J.A., Vizcaino, J., Basora-Gallisa, J., Núñez-Córdoba, J.M., Segarra, R., Hernández, P., Araque, M., García Roselló, J., Giardina, S., Macua-Martínez, T., Gutierrez, E., Toledo, E., Pedret, R., Guasch-Ferré, Marta, Baena, J.M., Pintó, Xavier, Díaz-López, A., Rosique-Esteban, N., Sanchez-Villegas, A., Fernández-Ballart, J., Parra, L., Velasco García, V., Balanza, R., Tello, S., Ramos, A., Simón García, C., Vila, J., Altés, A., Proenza, A., Álvarez-Pérez, J., de la Torre, Rafael, Muñoz-Aguayo, Daniel, Murillo, C., Fernández-Carrión, R., Rodríguez, M. A., Elosua, R., Tort, N., Casi, A., Falcón Sanabria, I., Marrugat, J., Amorós, M., Ruiz-Canela, M., Carratalá-Calvo, A., Mengual, L., Guillem-Saiz, P., Molina, N., Maestre, E., Gómez-Huelgas, R., Corbella, X., Cervello, T., González, R., Castañer, O., Farré, M., Sanz, E., González-Monje, I., Sánchez-Navarro, S., Carrasco, P., Ortega-Azorín, Carolina, Romaguera, D., Díez Benítez, E., Roura, P., Instituto de Salud Carlos III, Ministerio de Ciencia e Innovación (España), Junta de Andalucía, Hu, E.A., Martínez-González, Miguel Ángel, Salas-Salvadó, J., Corella, D., Ros, E., Fitó, Montserrat, García-Rodriguez, A., Estruch, R., Arós, F., Fiol, M., Lapetra, José, Asensio, E.M., Vázquez-Ruiz, Z., Canudas, S., Osma, R., Barragán, R., Muñoz, M.A., Martínez-González, J., Razquin, C., Valero-Barceló, C., Rovira, M.A., Tabar-Sarrias, J.A., Felipe, I., Francés, F., Guillén, M., González, J.I., Macías Gutiérrez, B., Tafalla, M., Bulló, M., Salaverria, I., Loma-Osorio, A., Baca Osorio, A., Pages, M.A., Altirriba, J., Munuera, S., Alonso, A., Sorlí, J., Vivó, M., Benitez Pont, R., Llauradó, M., Bestard, F., Montero Romero, Emilio, Molina, C., Rebholz, C.M., Munar, J.A., Sáiz, C., Cofán, M., Papandreou, C., Frontera, G., Coll, L., Quiles, L., Isach, A., Bes-Rastrollo, M., Perona, Javier S., Fernández-Urzainqui, L., Fiol, F., del Hierro, T., Mata, M., Ginard, M., Jover, A., Liroz, M., Parra-Osés, A., García, J., Gómez-Gracia, Enrique, Montull, I., Ariz-Arnedo, M.J., Santos-Lozano, J.M., Ortega-Calvo, M., Valls-Pedret, C., Bautista-Castaño, Inmaculada, García, M., Leal, M., Gil Zarzosa, J., Rico, A., Serra-Mir, M., Martínez, E., San Vicente, J., Mellado, L., Babio, N., Santana Santana, A.J., Benavent, J., Maldonado Díaz, I., Miró-Moriano, L., De la Fuente-Arrillaga, C., Rovira, A., Oller, M., Domínguez-Espinaco, C., Martínez, P., Bianchi Alba, M., Vaquero-Diaz, S., Iglesias, P., Cabezas, C., Sala-Vila, A., Fernández-Rodríguez, M. J., de la Cruz, E., Román, P., Corchado, Y., Solis, E., Cabeza-Beunza, J.A., Clos, J., Lozano-Rodríguez, J.M., Mestres, G., García-García, M., Lamuela-Raventós, Rosa M., López-Sabater, M.C., Duaso, I., Santamaria, M.I., Salas-Huetos, A., Galera, A., Simón, C., Vinyoles, E., Castellote-Bargalló, Ana I., Quifer-Rada, P., Gea, A., Pérez-Heras, A., Doménech, M., Becerra-Tomás, Nerea, Trias, F., García, L., Brau, A., Rekondo, J., Sáez, G., Corbella, Emili, de Diego Salas, J., Fernández-Montero, A., Yuste, M.C., Prieto, R., Pérez-de-Ciriza, P., Bobe, I., Navajas, R., Sánchez-Ruiz, D., Tresserra-Rimbau, A., Schröder, H., Jurado-Ruíz, Enrique, Portillo, María P., Buil-Cosiales, P., Sarmiendo de la Fe, F., Sánchez Luque, J.J., Ferreira, C., Zazpe, I., Díez-Espino, Javier, Sarasa, I., Sánchez, M.S., Sanjulian, B., Marti, A., Sorlí, J.V., Portolés, Olga, Martínez, J. Alfredo, Baby, P., Ibarrola-Jurado, Nuria, Serrano-Martínez, M., Sánchez-Tainta, A., Fernández-Crehuet, Joaquín, Pascual-Pascual, P., Pascual, V., García-Arellano, A., Fernández, M., Paris, F., Giménez, F.J., Basteara-Gortari, J., Extremera-Urabayen, J.V., Benítez Pont, R., Viñas, C., Algorta, J., Martínez-Mazo, M.D., Garcia-Pérez, L., Serra-Majem, L., Bonet, M.T., Riera, C., Arroyo-Azpa, C., Guarner, A., Sola-Larraza, A., Barcena, F., García, Y., Gutiérrez-Bedmar, M., Arina-Vergara, E., Casas, Ricard, Oreja-Arrayago, C., Lasanta-Sáez, M.J., Mena, G., Francisco, S., Cia-Lecumberri, P., García-Valdueza, M., Diáz, A., Elcarte-Lopez, T., Artal-Moneva, F., Godoy, D., Martín, M. T., Vargas López, E., Medina-Remón, Alexander, Iglesias, C., Esparza-López, J.M., Figuerido-Garmendia, E., Cabre, M., Coltell, O., Wärnberg, J., Ruiz-Gutiérrez, Valentina, Villanueva, P., Quinzavos, L., Manzano, E., Martín, F., Amat, J., de Juan, C., Basells, J., Pla, I., Tur, J.A., Vizcaino, J., Basora-Gallisa, J., Núñez-Córdoba, J.M., Segarra, R., Hernández, P., Araque, M., García Roselló, J., Giardina, S., Macua-Martínez, T., Gutierrez, E., Toledo, E., Pedret, R., Guasch-Ferré, Marta, Baena, J.M., Pintó, Xavier, Díaz-López, A., Rosique-Esteban, N., Sanchez-Villegas, A., Fernández-Ballart, J., Parra, L., Velasco García, V., Balanza, R., Tello, S., Ramos, A., Simón García, C., Vila, J., Altés, A., Proenza, A., Álvarez-Pérez, J., de la Torre, Rafael, Muñoz-Aguayo, Daniel, Murillo, C., Fernández-Carrión, R., Rodríguez, M. A., Elosua, R., Tort, N., Casi, A., Falcón Sanabria, I., Marrugat, J., Amorós, M., Ruiz-Canela, M., Carratalá-Calvo, A., Mengual, L., Guillem-Saiz, P., Molina, N., Maestre, E., Gómez-Huelgas, R., Corbella, X., Cervello, T., González, R., Castañer, O., Farré, M., Sanz, E., González-Monje, I., Sánchez-Navarro, S., Carrasco, P., Ortega-Azorín, Carolina, Romaguera, D., Díez Benítez, E., and Roura, P.

Abstract

Background: Potatoes have a high glycemic load but also antioxidants, vitamins, and minerals. It is unclear what mechanisms are involved in relation to their effect on blood pressure (BP) and hypertension. Objectives: This study aimed to assess the association between potato consumption, BP changes, and the risk of hypertension in 2 Spanish populations. Methods: Separate analyses were performed in PREDIMED (PREvención con DIeta MEDiterránea), a multicenter nutrition intervention trial of adults aged 55-80 y, and the SUN (Seguimiento Universidad de Navarra) project, a prospective cohort made up of university graduates and educated adults with ages (means±SDs) of 42.7±13.3 y for men and 35.1± 10.7 y for women. In PREDIMED, generalized estimating equations adjusted for lifestyle and dietary characteristics were used to assess changes in BP across quintiles of total potato consumption during a 4-y follow-up. Controlled BP values (systolic BP < 140 mm Hg and diastolic BP < 90 mm Hg) during follow-up were also assessed. For SUN, multivariateadjusted HRs for incident hypertension during a mean 6.7-y follow-up were calculated. Results: In PREDIMED, the total potato intake was 81.9 ± 40.6 g/d. No overall differences in systolic or diastolic BP changes were detected based on consumption of potatoes. For total potatoes, the mean difference in change between quintile 5 (highest intake) and quintile 1 (lowest intake) in systolic BP after multivariate adjustment was 20.90 mm Hg (95% CI: -2.56, 0.76 mm Hg; P-trend = 0.1) and for diastolic BP was 20.02 mm Hg (95% CI: -0.93, 0.89 mm Hg; P-trend = 0.8). In SUN, the total potato consumption was 52.7 ± 33.6 g/d, and no significant association between potato consumption and hypertension incidence was observed in the fully adjusted HR for total potato consumption (quintile 5 compared with quintile 1: 0.98; 95% CI: 0.80, 1.19; P-trend = 0.8). Conclusions: Potato consumption is not associated with changes over 4 y in blood pressure among o

Published
2017

49. Prediction of cardiovascular disease by the framingham-REGICOR equation in the high-risk PREDIMED cohort: Impact of the mediterranean diet across different risk strata

Author

Instituto de Salud Carlos III, Centro Nacional de Investigaciones Cardiovasculares (España), Ministerio de Ciencia e Innovación (España), California Walnut Commission, Amor, A.J., Serra-Mir, M., Martínez-González, M.A., Corella, D., Salas-Salvadó, J., Fitó, Montserrat, Estruch, R., Serra-Majem, L., Arós, F., Babio, N., Ros, E., Cofán, M., Lecea, O., Rosique Esteban, N., Valls-Pedret, C., Freitas-Simoes, T.M., Doménech, M., Gilabert, R., Sagredo Arce, T., Bertolín-Muñoz, A., Tresserra-Rimbau, A., Jurado-Ruíz, Enrique, Salaverría, I., Pages, M.A., Cabré, J.J., Mestres, G., Paris, F., Llauradó, M., Pedret, R., Basells, J., Vizcaino, J., Segarra, R., Sacanella, E., Casas, Ricard, Frontera, G., Alonso-Gómez, A., Godoy, D., López-Sabater, M.C., de la Torre, Rafael, del Hierro, T., Hernandez-Alonso, P., Giardina, S., Ferreira-Pego, C., Pérez-Cabrera, J., Papandreou, C., Baby, P., Camacho, L., Toledo, E., Casanas Quintana, T., Carratalá-Calvo, A., Buil-Cosiales, P., Rovira, A., Ruiz-Canela, M., Martínez, J. Alfredo, Fiol, Miquel, Castellote-Bargalló, Ana I., Algorta, J., Álvarez-Pérez, J., Sanjulian, B., Ortega, E., Sánchez-Tainta, A., Díez-Espino, Javier, Sánchez-Villegas, A., Ginard, M., Fiol, F., García-Valdueza, M., Marrugat, J., Schröder, H., Molina, N., Maestre, E., Castañer, O., Farré, M., Sorli, J.V., Ramos, A., García, J., Moñino, M., Santamaría, M.I., Fernández-Rodríguez, M. J., Jover, A., Pérez-Heras, A., Zanon-Moreno, V., Díaz-Benítez, E.M., Carrasco, P., Ortega-Azorín, Carolina, Asensio, E.M., Oller, M., Proenza, A., Osma, R., Bargalló, N., Barragán, R., Francés, F., García, M., Romaguera, D., Guillén, M., Márquez, F., González, J.I., Saiz, C., Portillo, María P., Mengual, L., Viñas, C., Bautista-Castaño, Inmaculada, de Santamaría, L., Portolés, Olga, Giménez, F.J., Coltell, O., Guillem-Saiz, P., Chiva, G., Mata, M., Sorli, M., de Juan, C., Roura, P., Rekondo, J., Belló, M.C., Loma-Osorio, A., Gómez-Gracia, Enrique, Warnberg, J., Benítez Pont, R., Bianchi Alba, M., Gómez-Huelgas, R., Gueto Rubio, M.V., Bulló, M., Sáez, G., Yuste, M.C., Martínez, P., Valderas, P., Brau, A., Martínez-González, J., Velasco García, V., Romero, S., de Diego Salas, J., Razquin, C., Baca Osorio, A., Gil Zarzosa, J., Becerra-Tomás, Nerea, Guarner, A., Sánchez Luque, J.J., Eguaras, S., Vargas López, E., Ruiz-Gutiérrez, Valentina, Ibarrola-Jurado, Nuria, Tur, J.A., García Roselló, J., Perona, Javier S., Vigata López, M.D., Montero Romero, Emilio, García-García, M., Isach, A., Basora, J., González, R., Nissensohn, M., Díaz-González, V., Ruano-Rodríguez, C., Ortiz-Andrelluchi, A.P., Macías Gutiérrez, B., Santana-Santana, A.J., Pintó, Xavier, de la Cruz, E., García-Arellano, A., Mena, G., Marti, A., Salas-Huetos, A., Díaz-López, A., Arceiz Campo, M.T., Arranz, S., Martín, F., Galera, A., Soler, Y., Trias, F., Elosua, R., Sarasa, I., Quiles, L., Padres, E., Corbella, Emili, Muñoz-Aguayo, Daniel, Molina, C., Cabezas, C., Martín-Rillo, M.J., Vinyoles, E., Rovira, M.A., Goñi, E., Urtasun Samper, A., Tort, N., Sola, A., García, L., Baena, J.M., Flores, G., Verdú, J.M., Tello, S., Arroyo-Azpa, C., García-Pérez, L., Vazquez, Z., Amat, J., Duaso, I., García, Y., Iglesias, C., Simón, C., Quinzavos, L., Parra, L., Liroz, M., Pascual, V., García de la Noceda Montoy, M.D., Berrade, N., Llopis-Osorio, E., Vila, J., Villanueva Telleria, J., Benavent, J., Clos, J., Pla, I., Amorós, M., Bonet, M.T., Sanz, E., Extremera-Urabayen, V., Martín, M. T., Prieto, R., Sánchez, M.S., Altirriba, J., Ruiz-Baixauli, J., Cortés Ugalde, F., Manzano, E., Lamuela-Raventós, Rosa M., Altés, A., Sala-Vila, A., Francisco, S., Riera, C., Instituto de Salud Carlos III, Centro Nacional de Investigaciones Cardiovasculares (España), Ministerio de Ciencia e Innovación (España), California Walnut Commission, Amor, A.J., Serra-Mir, M., Martínez-González, M.A., Corella, D., Salas-Salvadó, J., Fitó, Montserrat, Estruch, R., Serra-Majem, L., Arós, F., Babio, N., Ros, E., Cofán, M., Lecea, O., Rosique Esteban, N., Valls-Pedret, C., Freitas-Simoes, T.M., Doménech, M., Gilabert, R., Sagredo Arce, T., Bertolín-Muñoz, A., Tresserra-Rimbau, A., Jurado-Ruíz, Enrique, Salaverría, I., Pages, M.A., Cabré, J.J., Mestres, G., Paris, F., Llauradó, M., Pedret, R., Basells, J., Vizcaino, J., Segarra, R., Sacanella, E., Casas, Ricard, Frontera, G., Alonso-Gómez, A., Godoy, D., López-Sabater, M.C., de la Torre, Rafael, del Hierro, T., Hernandez-Alonso, P., Giardina, S., Ferreira-Pego, C., Pérez-Cabrera, J., Papandreou, C., Baby, P., Camacho, L., Toledo, E., Casanas Quintana, T., Carratalá-Calvo, A., Buil-Cosiales, P., Rovira, A., Ruiz-Canela, M., Martínez, J. Alfredo, Fiol, Miquel, Castellote-Bargalló, Ana I., Algorta, J., Álvarez-Pérez, J., Sanjulian, B., Ortega, E., Sánchez-Tainta, A., Díez-Espino, Javier, Sánchez-Villegas, A., Ginard, M., Fiol, F., García-Valdueza, M., Marrugat, J., Schröder, H., Molina, N., Maestre, E., Castañer, O., Farré, M., Sorli, J.V., Ramos, A., García, J., Moñino, M., Santamaría, M.I., Fernández-Rodríguez, M. J., Jover, A., Pérez-Heras, A., Zanon-Moreno, V., Díaz-Benítez, E.M., Carrasco, P., Ortega-Azorín, Carolina, Asensio, E.M., Oller, M., Proenza, A., Osma, R., Bargalló, N., Barragán, R., Francés, F., García, M., Romaguera, D., Guillén, M., Márquez, F., González, J.I., Saiz, C., Portillo, María P., Mengual, L., Viñas, C., Bautista-Castaño, Inmaculada, de Santamaría, L., Portolés, Olga, Giménez, F.J., Coltell, O., Guillem-Saiz, P., Chiva, G., Mata, M., Sorli, M., de Juan, C., Roura, P., Rekondo, J., Belló, M.C., Loma-Osorio, A., Gómez-Gracia, Enrique, Warnberg, J., Benítez Pont, R., Bianchi Alba, M., Gómez-Huelgas, R., Gueto Rubio, M.V., Bulló, M., Sáez, G., Yuste, M.C., Martínez, P., Valderas, P., Brau, A., Martínez-González, J., Velasco García, V., Romero, S., de Diego Salas, J., Razquin, C., Baca Osorio, A., Gil Zarzosa, J., Becerra-Tomás, Nerea, Guarner, A., Sánchez Luque, J.J., Eguaras, S., Vargas López, E., Ruiz-Gutiérrez, Valentina, Ibarrola-Jurado, Nuria, Tur, J.A., García Roselló, J., Perona, Javier S., Vigata López, M.D., Montero Romero, Emilio, García-García, M., Isach, A., Basora, J., González, R., Nissensohn, M., Díaz-González, V., Ruano-Rodríguez, C., Ortiz-Andrelluchi, A.P., Macías Gutiérrez, B., Santana-Santana, A.J., Pintó, Xavier, de la Cruz, E., García-Arellano, A., Mena, G., Marti, A., Salas-Huetos, A., Díaz-López, A., Arceiz Campo, M.T., Arranz, S., Martín, F., Galera, A., Soler, Y., Trias, F., Elosua, R., Sarasa, I., Quiles, L., Padres, E., Corbella, Emili, Muñoz-Aguayo, Daniel, Molina, C., Cabezas, C., Martín-Rillo, M.J., Vinyoles, E., Rovira, M.A., Goñi, E., Urtasun Samper, A., Tort, N., Sola, A., García, L., Baena, J.M., Flores, G., Verdú, J.M., Tello, S., Arroyo-Azpa, C., García-Pérez, L., Vazquez, Z., Amat, J., Duaso, I., García, Y., Iglesias, C., Simón, C., Quinzavos, L., Parra, L., Liroz, M., Pascual, V., García de la Noceda Montoy, M.D., Berrade, N., Llopis-Osorio, E., Vila, J., Villanueva Telleria, J., Benavent, J., Clos, J., Pla, I., Amorós, M., Bonet, M.T., Sanz, E., Extremera-Urabayen, V., Martín, M. T., Prieto, R., Sánchez, M.S., Altirriba, J., Ruiz-Baixauli, J., Cortés Ugalde, F., Manzano, E., Lamuela-Raventós, Rosa M., Altés, A., Sala-Vila, A., Francisco, S., and Riera, C.

Abstract

Background-The usefulness of cardiovascular disease (CVD) predictive equations in different populations is debatable. We assessed the efficacy of the Framingham-REGICOR scale, validated for the Spanish population, to identify future CVD in participants, who were predefined as being at high-risk in the PREvención con DIeta MEDiterránea (PREDIMED) study-a nutrition-intervention primary prevention trial-and the impact of adherence to the Mediterranean diet on CVD across risk categories. Methods and Results-In a post hoc analysis, we assessed the CVD predictive value of baseline estimated risk in 5966 PREDIMED participants (aged 55-74 years, 57% women; 48% with type 2 diabetes mellitus). Major CVD events, the primary PREDIMED end point, were an aggregate of myocardial infarction, stroke, and cardiovascular death. Multivariate-adjusted Cox regression was used to calculate hazard ratios for major CVD events and effect modification from the Mediterranean diet intervention across risk strata (low, moderate, high, very high). The Framingham-REGICOR classification of PREDIMED participants was 25.1% low risk, 44.5% moderate risk, and 30.4% high or very high risk. During 6-year follow-up, 188 major CVD events occurred. Hazard ratios for major CVD events increased in parallel with estimated risk (2.68, 4.24, and 6.60 for moderate, high, and very high risk), particularly in men (7.60, 13.16, and 15.85, respectively, versus 2.16, 2.28, and 3.51, respectively, in women). Yet among those with low or moderate risk, 32.2% and 74.3% of major CVD events occurred in men and women, respectively. Mediterranean diet adherence was associated with CVD risk reduction regardless of risk strata (P > 0.4 for interaction). Conclusions-Incident CVD increased in parallel with estimated risk in the PREDIMED cohort, but most events occurred in non- high-risk categories, particularly in women. Until predictive tools are improved, promotion of the Mediterranean diet might be useful to reduce CVD indepen

Published
2017

50. Arqueología informática: diseño e implementación de una calculadora tipo Leibniz con Scratch

Author

Pérez Heras, Salvador

Subjects
ARQUITECTURA Y TECNOLOGIA DE COMPUTADORES, Difusión de patrimonio, Dissemination of heritage, Grado en Ingeniería Informática-Grau en Enginyeria Informàtica, Museo de la informática, Calculadora Schubert, Scratch, Museum of Informatics, Calculadora Leibniz
Abstract

[ES] La calculadora de Leibniz fue creada en 1673 y fue un gran avance en la época. Dicha calculadora fue utilizada durante tres siglos por el mundo de la computación y sobretodo por su famoso Stepped Reckoner. Su creador fue el filósofo, matemático y político alemán Gottfried Wilhelm Leibniz. Este invento fue heredado por la mayor parte de las calculadoras mecánicas y ha sido la madre de prácticamente todos los aparatos matemáticos e informáticos de los que podemos hacer uso hoy en día. En este trabajo se pretende realizar un estudio histórico y un análisis de las distintas calculadoras que ha creado el ser humano, centrándonos en la de Leibniz y en la Schubert. A causa del gran valor histórico de las calculadoras mecánicas, este trabajo ha sido utilizado para dar a conocer este mecanismo en la página web destinada al Museo de Informática de la Escuela Técnica Superior de Ingeniería Informática de la UPV y contribuir así a la difusión del patrimonio digital. A parte, se ha realizado una aplicación en lenguaje SCRATCH del funcionamiento de la máquina calculadora Schubert, la cual va a servir también para mostrar interactivamente su uso a personas que no la conozcan., [CA] La calculadora de Leibniz va ser creada a l’any 1673 i va ser un gran avanç en l’època. Aquesta calculadora va ser utilitzada durant tres segles pel món de la computació i sobretot pel seu famós Stepped Reckoner. El seu creador va ser el filòsof, matemàtic i polític alemany Gottfried Wilhelm Leibniz. Aquest invent va ser heretat per la major part de les calculadores mecàniques i ha sigut la mare de pràcticament tots els aparells matemàtics i informàtics dels quals podem fer ús avui en dia. En aquest treball es pretén realitzar un estudi històric i una anàlisi de les diferents calculadores que ha creat l’ésser humà, centrant-nos en la de Leibniz i en la Schubert. A causa del gran valor històric de les calculadores mecàniques, aquest treball ha sigut utilitzat per donar a conèixer aquest mecanisme a la pàgina web destinada al Museu d’Informàtica de l’Escola Tècnica Superior d’Enginyeria Informàtica de la UPV i contribuir així a la difusió del patrimoni digital. Ademés, s’ha realitzat una aplicació en llenguatge SCRATCH del funcionament de la màquina calculadora Schubert, la qual va a servir també per mostrar interactivament el seu ús a persones que no la coneguen., [EN] Leibniz calculator was created in 1673 and it was a breakthrough at the time. This calculator was used for three centuries by the computing world and especially for its famous Stepped Reckoner. Its creator was the German philosopher, mathematician and politician Gottfried Wilhelm Leibniz. This invention was inherited by most of the mechanical calculators and it was the mother of almost all mathematical and computing devices that can make use today. In this work we aim to make a historical study and analysis of the different calculators that created the human being, focusing on Leibniz and the Schubert. Because of the great historical value of mechanical calculators, this work has been used to publicize this mechanism on the website for the Museum of Informatics School of Engineering of the UPV and contribute to the dissemination of the heritage digital. Besides, it has been created an application on SCRATCH language of the performance of Schubert calculating machine, which will also serve to show its use interactively to people who do not know the calculator.

Published
2016

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