1. Low serum albumin level deteriorates prognosis in azacitidine-treated myelodysplastic syndromes patients - results of the PALG study 'PolAZA'
- Author
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Katarzyna Kapelko-Słowik, Magdalena Czemerska, Piotr Centkowski, Anna Waszczuk-Gajda, Sara Zawadzka-Leska, Wioletta Makowska, Rafał Machowicz, Aleksandra Gołos, Jadwiga Hołojda, Patrycja Rusicka, Grzegorz W. Basak, Edyta Subocz, Karol Lis, Anna Masternak, Bartłomiej Pogłódek, Joanna Drozd-Sokołowska, Tomasz Czerw, Elżbieta Wiater, Andrzej Tukiendorf, Jadwiga Dwilewicz-Trojaczek, Anna Kopińska, Krzysztof Mądry, Janusz Hałka, and Paweł Szwedyk
- Subjects
Adult ,Male ,medicine.medical_specialty ,Antimetabolites, Antineoplastic ,Standard of care ,Azacitidine ,Serum Albumin, Human ,Internal medicine ,Intensive therapy ,hemic and lymphatic diseases ,medicine ,Humans ,Aged ,Retrospective Studies ,Aged, 80 and over ,business.industry ,Myelodysplastic syndromes ,Albumin ,Hematology ,Middle Aged ,medicine.disease ,Prognosis ,Clinical trial ,Treatment Outcome ,Myelodysplastic Syndromes ,Female ,Low serum albumin ,business ,medicine.drug - Abstract
Azacitidine (AZA) is the standard of care for higher-risk myelodysplastic syndrome (HR-MDS) patients ineligible for intensive therapy. Clinical outcome discrepancies reported in clinical trials and real-life settings stimulate the search for new prognostic factors. We retrospectively evaluated 315 MDS, 20–30% blast acute myeloid leukemia (AML) and chronic myelomonocytic leukemia (CMML) patients treated with azacitidine in 12 centers cooperating within the Polish Adult Leukemia Group (PALG). The median number of AZA cycles was 7 (1–69) and 24% patients received fewer than 4 cycles (early failure, EF). Serum albumin level was an independent predictor of EF occurrence. Complete remission (CR) was obtained in 20% and partial remission (PR) in 12% of patients. Hematologic improvement – erythroid (HI-E), neutrophil (HI-N), or platelet (HI-P) was achieved in 51%, 36%, and 48% of patients, respectively. No factors significantly predicted CR or PR in the multivariate analysis. For HI-E and HI-P, lower LDH level predicted response. Median survival was 15 (13–19) months. Lower serum albumin level, serious infection and receiving p < 0.05). Serum albumin assessment before azacitidine treatment can help to identify patients with higher risk of early failure and worse clinical outcome.
- Published
- 2021