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This article, published in the journal Ultrasound in Obstetrics & Gynecology, evaluates the effectiveness of screening for late-onset pre-eclampsia (PE) between 35 and 38 weeks of gestation using maternal and biophysical factors. The study included 949 pregnancies, with 46 (4.8%) developing PE. The results showed that screening with a combination of maternal factors (age and BMI) and mean arterial pressure (MAP) could identify a high proportion of pregnancies at risk for late-onset PE. The authors suggest that this screening method could be useful in identifying and managing pregnancies at risk for PE. [Extracted from the article]

This article analyzes the perinatal outcomes and complications associated with laser fetoscopy for the treatment of Twin-twin transfusion syndrome (TTTS) in two Chilean hospitals. The study examined 144 laser therapy procedures performed between December 2008 and June 2023. The results showed that the overall survival rate at one month of life for TTTS cases treated with laser therapy was 63.1%, with a survival rate of both twins at 45.4%. The study concludes that the Chilean hospitals have achieved similar results to international centers with high experience in fetal therapy, establishing them as references for such procedures. [Extracted from the article]

This article, titled "OP15.05: First trimester fetal growth: a screening tool for small-for-gestational-age newborns," discusses a study that aimed to develop a predictive model for identifying newborns who are small for gestational age (SGA) in the first trimester. The study involved 3,238 women with a singleton pregnancy and assessed factors such as Crown-rump length (CRL) and uterine artery Doppler (UAD). The results showed that reduced CRL growth in the first trimester is associated with SGA below the third percentile. A combined model including maternal characteristics, CRL growth, and UAD can predict around half of pregnancies with preterm SGA. [Extracted from the article]

This article discusses a study conducted at the Fetal Medicine Unit of the University of Chile Hospital between 2018 and 2020. The study aimed to determine the impact of changes in the uterine artery pulsatility index (UtA-PI) on the outcomes of pregnant women using aspirin to prevent preterm pre-eclampsia (PE). The study found that pregnant women at high risk of preterm PE who were treated with aspirin had greater uterine artery vasodilation between the first and second trimesters compared to control pregnant women. However, further research with a larger sample size is needed to confirm these findings. [Extracted from the article]

This article discusses the perinatal outcomes of twin reverse arterial perfusion (TRAP) sequence in two centers in Chile. The study analyzed a cohort of fetal therapy cases for TRAP sequence between 2010 and 2023. Out of the 14 cases with complete results, 3 were managed using bipolar coagulation (BPC) and 11 underwent intrapelvic laser (IPL) therapy. The average gestational age for therapy was 19+3 weeks. The study found that pregnancies complicated by TRAP sequence have high rates of prenatal morbidity and mortality, but early diagnosis allows for timely intervention to protect the pump twin. [Extracted from the article]

This article presents a study conducted at the Fetal Medicine Unit of Hospital Clínico de la Universidad de Chile, aiming to develop a predictive model for assessing the risk of trisomy 21 (T21) between 20 to 25 weeks of gestation. The study included 3,125 singleton pregnancies and utilized a combination of categorical and quantitative markers such as maternal age, nasal bone length, prenasal thickness, and others. The multivariate model demonstrated a sensitivity of 70.6% and a false positive rate of 2.5%, with an area under the curve (AUC) of 0.975. The integration of second trimester markers with a quantitative approach was found to facilitate personalized T21 risk prediction during this gestational period. [Extracted from the article]

This article, titled "EP09.105: Persistent left superior vena cava: prenatal diagnosis and associations," discusses the prevalence and clinical significance of the prenatal diagnosis of persistent left superior vena cava (LSVC) and its relationship with other cardiac and extracardiac anomalies. The study, conducted between 2005 and 2022 at the Fetal Medicine Unit of the Clinical Hospital of the University of Chile, evaluated 44,728 pregnancies and identified 19 cases of LSVC. The prevalence of LSVC was found to be lower than expected but showed a progressive increase over time. The article emphasizes the importance of systematic screening views for congenital heart disease and recommends thorough morphological examination and echocardiography in cases of suspected LSVC. Routine chromosomal study is not suggested in isolated cases but is strongly recommended in cases with other anomalies. The efficiency of this marker should be further studied in prospective studies. [Extracted from the article]

This article, titled "Use of the cardiovascular resistance index to predict labetalol non-response in the management of hypertensive crisis during pregnancy," explores the role of hemodynamic and biophysical markers in predicting treatment failure with labetalol for hypertensive crisis during pregnancy. The study involved 44 pregnancies, with 57% identified as non-responders to labetalol. Non-responders had a higher cardiovascular resistance index and lower gestational age compared to responders. The findings suggest that recognizing specific hemodynamic profiles is important for personalized management of severe hypertension during pregnancy. [Extracted from the article]

This article discusses a study conducted at the Hospital Clínico Universidad de Chile on the impact of Doppler and gestational age (GA) on the prediction of adverse perinatal outcomes (APO) in fetuses with late-onset fetal growth restriction (lateFGR). The study included 495 cases of lateFGR, with an APO rate of 20.4%. The results showed that predictors of APO were a cerebroplacental ratio (CPR) below the 5th percentile and GA below 34 weeks at FGR diagnosis. The study concludes that altered CPR and gestational age at diagnosis are directly related to APO in late-onset FGR fetuses, and the use of CPR appears to have a predictive role in the subgroup between 32 and 34 weeks of gestation. [Extracted from the article]

This article discusses a study that evaluated the performance of new craniofacial markers for predicting Trisomy 21 (T21) during second trimester screening ultrasounds. The study included singleton pregnancies at the Fetal Medicine Unit of Hospital Clínico de la Universidad de Chile between 2004 and 2017. The researchers found that certain craniofacial markers, including prenasal thickness (PNT) and nasal bone length (NBL), were higher in fetuses with T21 compared to euploid fetuses. However, the researchers concluded that further development of reference curves based on the local population is necessary for the utilization of these markers. [Extracted from the article]