EP18.18: Development of a multivariate predictive model for Trisomy 21 risk assessment at 20–25 weeks of gestation.

This article presents a study conducted at the Fetal Medicine Unit of Hospital Clínico de la Universidad de Chile, aiming to develop a predictive model for assessing the risk of trisomy 21 (T21) between 20 to 25 weeks of gestation. The study included 3,125 singleton pregnancies and utilized a combination of categorical and quantitative markers such as maternal age, nasal bone length, prenasal thickness, and others. The multivariate model demonstrated a sensitivity of 70.6% and a false positive rate of 2.5%, with an area under the curve (AUC) of 0.975. The integration of second trimester markers with a quantitative approach was found to facilitate personalized T21 risk prediction during this gestational period. [Extracted from the article]