Author: "Park RS" - Searchworks@Jio Institute Digital Library Search Results

55 results on '"Park RS"'

1. Observations, Meteorites, and Models: A Preflight Assessment of the Composition and Formation of (16) Psyche.

Author: Elkins-Tanton, LT, Asphaug, E, Bell, JF, Bercovici, H, Bills, B, Binzel, R, Bottke, WF, Dibb, S, Lawrence, DJ, Marchi, S, McCoy, TJ, Oran, R, Park, RS, Peplowski, PN, Polanskey, CA, Prettyman, TH, Russell, CT, Schaefer, L, Weiss, BP, Wieczorek, MA, Williams, DA, and Zuber, MT
Subjects: NASA, Psyche, asteroid, density, meteorite, Astronomical and Space Sciences, Geochemistry, Geology
Abstract: Some years ago, the consensus was that asteroid (16) Psyche was almost entirely metal. New data on density, radar properties, and spectral signatures indicate that the asteroid is something perhaps even more enigmatic: a mixed metal and silicate world. Here we combine observations of Psyche with data from meteorites and models for planetesimal formation to produce the best current hypotheses for Psyche's properties and provenance. Psyche's bulk density appears to be between 3,400 and 4,100 kg m-3. Psyche is thus predicted to have between ~30 and ~60 vol% metal, with the remainder likely low-iron silicate rock and not more than ~20% porosity. Though their density is similar, mesosiderites are an unlikely analog to bulk Psyche because mesosiderites have far more iron-rich silicates than Psyche appears to have. CB chondrites match both Psyche's density and spectral properties, as can some pallasites, although typical pallasitic olivine contains too much iron to be consistent with the reflectance spectra. Final answers, as well as resolution of contradictions in the data set of Psyche physical properties, for example, the thermal inertia measurements, may not be resolved until the NASA Psyche mission arrives in orbit at the asteroid. Despite the range of compositions and formation processes for Psyche allowed by the current data, the science payload of the Psyche mission (magnetometers, multispectral imagers, neutron spectrometer, and a gamma-ray spectrometer) will produce data sets that distinguish among the models.
Published: 2020

2. Observations, Meteorites, and Models: A Preflight Assessment of the Composition and Formation of (16) Psyche

Author: Massachusetts Institute of Technology. Department of Earth, Atmospheric, and Planetary Sciences, Elkins-Tanton, LT, Asphaug, E, Bell, JF, Bercovici, H, Bills, B, Binzel, R, Bottke, WF, Dibb, S, Lawrence, DJ, Marchi, S, McCoy, TJ, Oran, R, Park, RS, Peplowski, PN, Polanskey, CA, Prettyman, TH, Russell, CT, Schaefer, L, Weiss, BP, Wieczorek, MA, Williams, DA, Zuber, MT, Massachusetts Institute of Technology. Department of Earth, Atmospheric, and Planetary Sciences, Elkins-Tanton, LT, Asphaug, E, Bell, JF, Bercovici, H, Bills, B, Binzel, R, Bottke, WF, Dibb, S, Lawrence, DJ, Marchi, S, McCoy, TJ, Oran, R, Park, RS, Peplowski, PN, Polanskey, CA, Prettyman, TH, Russell, CT, Schaefer, L, Weiss, BP, Wieczorek, MA, Williams, DA, and Zuber, MT
Abstract: © 2020. The Authors. Some years ago, the consensus was that asteroid (16) Psyche was almost entirely metal. New data on density, radar properties, and spectral signatures indicate that the asteroid is something perhaps even more enigmatic: a mixed metal and silicate world. Here we combine observations of Psyche with data from meteorites and models for planetesimal formation to produce the best current hypotheses for Psyche's properties and provenance. Psyche's bulk density appears to be between 3,400 and 4,100 kg m−3. Psyche is thus predicted to have between ~30 and ~60 vol% metal, with the remainder likely low-iron silicate rock and not more than ~20% porosity. Though their density is similar, mesosiderites are an unlikely analog to bulk Psyche because mesosiderites have far more iron-rich silicates than Psyche appears to have. CB chondrites match both Psyche's density and spectral properties, as can some pallasites, although typical pallasitic olivine contains too much iron to be consistent with the reflectance spectra. Final answers, as well as resolution of contradictions in the data set of Psyche physical properties, for example, the thermal inertia measurements, may not be resolved until the NASA Psyche mission arrives in orbit at the asteroid. Despite the range of compositions and formation processes for Psyche allowed by the current data, the science payload of the Psyche mission (magnetometers, multispectral imagers, neutron spectrometer, and a gamma-ray spectrometer) will produce data sets that distinguish among the models.
Published: 2021

3. Reframing Catholic and Islamic political theologies: the human good as a basis for public civility

Author: Park, RS and Chapman, MD
Subjects: Theology and Religion
Abstract: With the rise of religious plurality and the global public resurgence of religion, deep social unrest and even fatal violence have resulted in a compelling need for plural societies to construct a framework of ‘public civility’. Recently, secularist frameworks such as multiculturalism and legal pluralism have been put forward. Yet, insofar as these approaches are considered non-moral, they are relativistic, and thereby lack the resources needed to ground a universal public civility. Also, approaches to building a ‘just society’ within both Catholic social thought and Islamic jurisprudence have been made specifically on the basis of ‘the common good’. The problem with these approaches is that the so-called ‘common good’ is internally defined such that the ‘good’ is ineluctably uncommon. A more promising basis on which to construct a universal framework of public civility is found in the classical notion of ‘the human good’.The argument proceeds in three main stages: (1) a critical assessment of ideological and sociological forces which have resulted in the fragmentation of modern society and the decline of public life; (2) a delineation of ‘the human good’ on the basis of which I construct a framework of public civility between Catholic and Islamic traditions; and (3) an illustration of the proposed framework in Mindanao, Philippines which represents one of the longest standing internal conflicts in history.The main contention is that Catholic and Islamic political theologies enhance the construction of public civility when reframed in terms of ‘the human good’ in contrast to ‘the common good’. In support of this thesis, I explore the Catholic doctrine of the imago dei and the Islamic notion of fiṭra as prospective conceptual counterparts to the idea of ‘the human good’. I conclude by analyzing the cosmopolitan scope of a framework of public civility as based on ‘the human good’.
Published: 2016

4. Precision electroweak measurements on the Z resonance

Author: Schael, S, Barate, R, Bruneliere, R, Buskulic, D, Bonis, De, Decamp, I, Ghez, D, Goy, P, Jezequel, C, Lees, S, Lucotte, Jp, Martin, A, Merle, F, Minard, E, Nief, Mn, Odier, Jy, Pietrzyk, P, Trocme, B, Bravo, B, Casado, S, Chmeissani, Mp, Comas, M, Crespo, P, Fernandez, Jm, E, Fernandez, Bosman, Garrido, M, Grauges, L, Juste, E, Martinez, A, Merino, M, Miquel, G, Mir, R, Orteu, Lm, Pacheco, S, Park, A, Perlas, Ic, Riu, J, Ruiz, I, Sanchez, H, Colaleo, F, Creanza, A, D, Filippis, De, N, Palma, De, Iaselli, M, Maggi, G, Nuzzo, M, Ranieri, S, Raso, A, Ruggieri, G, Selvaggi, F, Silvestris, G, Tempesta, L, Tricomi, P, Zito, A, Huang, G, Lin, X, Ouyang, J, Wang, Q, Xie, T, Xu, Y, Xue, R, Zhang, S, Zhang, J, Zhao, L, Abbaneo, W, Bazarko, D, Becker, A, Boix, U, Bird, G, Blucher, F, Bonvicini, E, B, Bright, Thomas, Barklow, P, Buchmuller, T, Cattaneo, O, Cerutti, M, Ciulli, F, Clerbaux, V, Drevermann, B, Forty, H, Frank, Rw, Greening, M, Hagelberg, Tc, Halley, R, Gianotti, Aw, Girone, F, Hansen, M, Harvey, Jb, Jacobsen, J, Hutchcroft, R, Janot, De, Jost, R, Knobloch, B, Kado, J, Lehraus, M, Lazeyras, I, Maley, P, Mato, R, May, P, Moutussi, J, A, Pepe, Altarelli, Ranjard, M, Rolandi, F, Schlatter, L, Schmitt, D, Schneider, B, Tejessy, O, Teubert, W, Tomalin, F, Tournefier, Ir, Veenhof, E, Valassi, R, Wiedenmann, A, Wright, W, Ajaltouni, Ae, Badaud, Z, Chazelle, F, Deschamps, G, Dessagne, O, Falvard, S, Ferdi, A, Fayolle, C, Gay, D, Guicheney, P, Henrard, C, Jousset, P, Michel, J, Monteil, B, Montret, S, Pallin, Jc, Pascolo, D, Perret, Jm, Podlyski, P, Bertelsen, F, Fernley, H, Hansen, T, Hansen, Jd, Hansen, Jr, Kraan, Ph, Lindahl, Ac, Mollerud, A, Nilsson, R, Rensch, Bs, Waananen, B, Daskalakis, A, Kyriakis, G, Markou, A, Simopoulou, C, Siotis, E, Vayaki, I, Zachariadou, A, Blondel, K, Bonneaud, A, Brient, G, Machefert, Jc, Rouge, E, Rumpf, A, Swynghedauw, M, Tanaka, M, Verderi, R, Videau, M, Focardi, H, Parrini, E, Corden, G, Georgiopoulos, M, Antonelli, C, Antonelli, A, Bencivenni, M, Bologna, G, Bossi, G, Campana, F, Capon, P, Chiarella, G, Felici, V, Laurelli, G, Mannocchi, P, Murtas, G, Passalacqua, Gp, Picchi, L, Colrain, P, P, Ten, Have, Hughes, I, Kennedy, Is, Knowles, J, Lynch, Ig, Morton, Jg, Negus, Wt, Oshea, P., Raine, V, Reeves, C, Scarr, P, Smith, Jm, Thompson, K., Turnbull, As, Wasserbaech, Rm, Cavanaugh, S, Dhamotharan, R, Geweniger, S, Hanke, C, Hansper, P, Hepp, G, Kluge, V, Putzer, Ee, Sommer, A, Stenzel, J, Tittel, H, Werner, K, Wunsch, W, Beuselinck, M, Binnie, R, Cameron, Dm, Davies, W, Dornan, G, Goodsir, Pj, Marinelli, S, Martin, N, Nash, Eb, Nowell, J, Rutherford, J, Sedgbeer, Sa, Thompson, Jk, White, Jc, Williams, R, Ghete, Md, Girtler, Vm, Kneringer, P, Kuhn, E, Rudolph, D, G, Bouhova, Thacker, Bowdery, E, Buck, Ck, Clarke, Pg, Ellis, Dp, Finch, G, Foster, Aj, Hughes, F, Jones, G, Rwl, Keemer, Pearson, Nr, Robertson, Mr, Sloan, Na, Smizanska, T, Snow, M, Williams, Sw, van der Aa, Delaere, O, Leibenguth, C, Lemaitre, G, Bauerdick, V, Lat, Blumenschein, U, Van, Gemmeren, Giehl, P, Holldorfer, I, Jakobs, F, Kasemann, K, Kayser, M, Kleinknecht, F, Muller, K, Quast, As, Renk, G, Rohne, B, Sander, E, Schmeling, Hg, Wachsmuth, S, Wanke, H, Zeitnitz, R, Ziegler, C, Aubert, T, Benchouk, Jj, Bonissent, C, Carr, A, Coyle, J, Curtil, P, Ealet, C, Etienne, A, Fouchez, F, Motsch, D, Payre, F, Rousseau, P, Tilquin, D, Talby, A, Thulasides, M, Aleppo, M, Ragusa, M, Buscher, F, David, V, Dietl, A, Ganis, H, Huttmann, G, Lutjens, K, Mannert, G, Manner, C, Moser, W, Settles, Hg, Seywerd, R, Villegas, H, Wolf, M, Azzurri, G, Boucrot, P, Callot, J, Chen, O, Cordier, S, Davier, A, Duflot, M, Grivaz, L, Heusse, Jf, Jacholkowska, P, Diberder, Le, Lefrancois, F, Mutz, J, Schune, Am, Serin, Mh, Veillet, L, Videau, Jj, Zerwas, I, Bagliesi, D, Bettarini, G, Boccali, S, Bozzi, T, Calderini, C, Dellorso, G, Fantechi, R, Ferrante, R, Fidecaro, I, Foa, F, Giammanco, L, Giassi, A, Gregorio, A, Ligabue, A, Lusiani, F, Marrocchesi, PIER SIMONE, Messineo, Ps, Palla, A, Rizzo, F, Sanguinetti, G, Sciaba, G, Sguazzoni, A, Spagnolo, G, Steinberger, P, Tenchini, J, Venturi, R, Vannini, A, Verdini, C, Awunor, Pg, Blair, O, Cowan, Ga, Garcia, Bellido, Green, A, Medcalf, Mg, Misiejuk, T, Strong, A, Teixeira, Dias, Botterill, P, Clifft, Dr, Edgecock, Rw, Edwards, Tr, Haywood, M, Norton, Sj, Ward, Pr, Bloch, Devaux, Boumediene, B, Colas, D, Emery, P, Fabbro, S, Kozanecki, B, Lancon, W, Lemaire, E, Locci, Mc, Perez, E, Rander, P, Renardy, J, Roussarie, Jf, Schuller, A, Schwindling, Jp, Tuchming, J, Vallage, B, Black, B, Dann, Sn, Kim, Jh, Konstantinidis, Hy, Litke, N, Mcneil, Am, Taylor, Ma, Booth, G, Cartwright, Cn, Combley, S, Hodgson, F, Lehto, Pn, Thompson, M, Affholderbach, Lf, Barberio, K, Bohrer, E, Brandt, A, Burkhardt, S, Feigl, H, Grupen, E, Hess, C, Lutters, J, Meinhard, G, H, Minguet, Rodriguez, Mirabito, J, Neugebauer, L, Ngac, E, Prange, A, Rivera, G, Saraiva, F, Schafer, P, Sieler, U, Smolik, U, Stephan, L, Trier, F, Apollonio, H, Borean, M, Bosisio, C, L, Della, Marina, Giannini, R, Gobbo, G, Musolino, B, Pitis, G, He, L, Kim, H, Putz, H, Rothberg, J, Armstrong, J, Bellantoni, Sr, Berkelman, L, Cinabro, K, Conway, D, Cranmer, Js, Elmer, K, Feng, P, Ferguson, Z, Dps, Gao, Gonzalez, Y, Grahl, S, Harton, J, Hayes, Jl, Hu, Oj, Jin, H, Johnson, S, Kile, Rp, Mcnamara, J, Nielsen, Pa, Orejudos, J, Pan, W, Saadi, Y, Scott, Y, Sharma, Ij, Walsh, V, Walsh, Am, Wear, J, J, von Wimmersperg Toeller, Wu, Jh, Wu, J, Wu, Sl, Yamartino, X, Zobernig, Jm, Dissertori, G, Abdallah, G, Abreu, J, Adam, P, Adye, W, Adzic, T, Ajinenko, P, Albrecht, I, Alderweireld, T, Alekseev, T, Alemany, Fernandez, Allmendinger, R, Allport, T, Almehed, Pp, Amaldi, S, Amapane, U, Amato, N, Anashkin, S, Anassontzis, E, Andersson, Eg, Andreazza, P, Andringa, A, Anjos, S, Antilous, N, Apel, P, Arnoud, Wd, Ask, Y, Asman, S, Augustin, B, Augustinus, Je, Baillon, A, Ballestrero, P, Bambade, A, Barao, P, Barbiellini, F, Barbier, G, Bardin, R, Barker, D, Baroncelli, G, Battaglia, A, Baubillier, M, Becks, M, Begalli, Kh, Behrmann, M, Beilliere, A, Belokopytov, P, Belous, Y, K, Ben, Haim, Benekos, E, Benvenuti, N, Berat, A, Berggren, C, Berntzon, M, Bertini, L, Bertrand, D, Besancon, D, Besson, M, Bianchi, N, Bigi, F, Bilenky, M, Bizouard, Ms, Bloch, Ma, Blom, D, Bluj, M, Bonesini, M, Bonivento, M, Boonekamp, W, Booth, M, Psl, Borgland, Borisov, Aw, Bosio, G, Botner, C, Boudinov, O, Bouquet, E, Bourdarios, B, Bowcock, C, Tjv, Boyko, Bozovic, I, Bozzo, I, Bracko, M, Branchini, M, Brenke, P, Brenner, T, Brodet, R, Bruckman, E, Brunet, P, Bugge, Jm, Buran, L, Burgsmueller, T, Buschbeck, T, Buschmann, B, Cabrera, P, Caccia, S, Calvi, M, Rozas, M, Ajc, Camporesi, Canale, T, Canepa, V, Carena, M, Carroll, F, Caso, L, Gimenez, C, Mvc, Castro, Cattai, N, Cavallo, A, Cerruti, F, Chabaud, C, Chapkin, V, Charpentier, M, Chaussard, P, Checchia, L, Chelkov, P, Chen, Ga, Chierici, M, Chliapnikov, R, Chochula, R, Chorowicz, P, Chudoba, V, Chung, J, Cieslik, Su, Collins, K, Colomer, P, Contri, M, Cortina, R, Cosme, E, Cossuti, G, Costa, F, Cowell, Mj, Crawley, Jh, Crennell, Hb, Crepe, D, Crosetti, S, Cuevas, G, Czellar, J, Dhondt, S, Dalmagne, J, Dalmau, B, Damgaard, J, Davenport, G, M, Silva, Da, T, Deghorain, W, Della, Ricca, Delpierre, G, Demaria, P, Angelis, De, Boer, De, W, Brabandere, De, S, Clercq, De, C, Lotto, De, Maria, De, Min, De, Paula, De, Dijkstra, L, Ciaccio, Di, Diodato, Di, Simone, Di, Djannati, A, Dolbeau, A, Doroba, J, Dracos, K, Drees, M, Drees, J, Dris, Ka, Duperrin, M, Durand, A, Ehret, Jd, Eigen, R, Ekelof, G, Ekspong, T, Ellert, G, Elsing, M, Engel, M, Erzen, Jp, Santo, B, Mce, Falk, Fanourakis, E, Fassouliotis, G, Fayot, D, Feindt, J, Fenyuk, M, Fernandez, A, Ferrari, J, Ferrer, P, Ferrer, Ribas, Ferro, E, Fichet, F, Firestone, S, Fischer, A, Flagmeyer, Pa, Foeth, U, Fokitis, H, Fontanelli, E, Franek, F, Frodesen, B, Fruhwirth, Ag, R, Fulda, Quenzer, Fuster, F, Galloni, J, Gamba, A, Gamblin, D, Gandelman, S, Garcia, M, Garcia, C, Gaspar, J, Gaspar, C, Gasparini, M, Gavillet, U, Gazis, P, Gele, E, Gerber, D, Gerdyukov, Jp, Ghodbane, L, Gil, N, Glege, I, Gokieli, F, Golob, R, Gomez, Ceballos, Goncalves, G, Caballero, P, Gopal, Ig, Gorn, G, Gorski, L, Gouz, M, Gracco, Y, Graziani, V, Green, E, Grefrath, C, Grimm, A, Gris, Hj, Grosdidier, P, Grzelak, G, Gunther, K, Guy, M, Haag, J, Hahn, C, Hahn, F, Hallgren, S, Hamacher, A, Hamilton, K, Hansen, K, Harris, J, Haug, Fj, Hauler, S, Hedberg, F, Heising, V, Hennecke, S, Henriques, M, Hernandez, R, Herquet, Jj, Herr, P, Hessing, H, Heuser, Tl, Higon, Jm, Hoffman, E, Holmgren, J, Holt, So, Holthuizen, Pj, Hoorelbeke, D, Houlden, S, Hrubec, Ma, Huber, J, Huet, M, Hughes, K, Hultqvist, Gj, Jackson, K, Jacobsson, Jn, Jalocha, R, Janik, P, Jarlskog, R, Jarlskog, C, Jarry, G, Jean, Marie, Jeans, B, Johansson, D, Johansson, Ek, Jonsson, Pd, Joram, P, Juillot, C, Jungermann, P, Kapusta, L, Karafasoulis, F, Katsanevas, K, Katsoufis, S, Keranen, E, Kernel, R, Kersevan, G, Kerzel, Bp, Khomenko, U, Khovanski, Ba, Kiiskinen, Nn, King, A, Kinvig, Bt, Kjaer, A, Klapp, Nj, Klein, O, Kluit, H, Knoblauch, P, Kokkinias, D, Konopliannikov, P, Koratzinos, A, Kostioukhine, M, Kourkoumelis, V, Kouznetsov, C, Krammer, O, Kreuter, M, Kriznic, C, Krstic, E, Krumstein, J, Kubinec, Z, Kucewicz, P, Kucharczyk, W, Kurowska, M, Kurvinen, J, Lamsa, K, Lanceri, J, Lane, L, Langefeld, Dw, Lapin, P, Laugier, V, Lauhakangas, Jp, Leder, R, Ledroit, G, Lefebure, F, Leinonen, V, Leisos, L, Leitner, A, Lemonne, R, Lenzen, J, Lepeltier, G, Lesiak, V, Lethuillier, T, Libby, M, Liebig, J, Liko, W, Lipniacka, D, Lippi, A, Loerstad, I, Lokajicek, B, Loken, M, Lopes, Jg, Lopez, Jh, Lopez, Femandez, Loukas, R, Lutz, D, Lyons, P, Macnaughton, L, Mahon, J, Maio, Jr, Malek, A, Malmgren, A, Tgm, Maltezos, Malychev, S, Mandl, V, Marco, F, Marco, J, Marechal, R, Margoni, B, Marin, M, Mariotti, Jc, Markou, C, Martinez, Rivero, Martinez, Vidal, Garcia, F, Smi, Masik, Mastroyiannopoulos, J, Matorras, N, Matteuzzi, F, Matthiae, C, Mazik, G, Mazzucato, J, Mazzucato, F, Mccubbin, M, Mckay, M, Mcnulty, R, Meroni, R, Meyer, C, Miagkov, Wt, Migliore, A, Mitaroff, E, Mjoernmark, W, Moa, U, Moch, T, Moeller, M, Moenig, R, Monge, K, Montenegro, R, Moraes, J, Moreau, D, Moreno, X, Morettini, S, Morton, P, Mueller, G, Muenich, U, Mulders, K, Mulet, Marquis, Mundim, C, Muresan, L, Murray, R, Muryn, W, Myatt, B, Myklebust, G, Naraghi, T, Nassiakou, F, Navarria, M, Navas, F, Nawrocki, S, Negri, K, Neufeld, P, Neumann, N, Neumeister, W, Nicolaidou, N, Nielsen, R, Nieuwenhuizen, Bs, Niezurawski, M, Nikolaenko, P, Nikolenko, V, Nomokonov, M, Normand, V, Nygren, A, Oblakowska, Mucha, Obraztsov, A, Olshevski, V, Onofre, A, Orava, A, Orazi, R, Osterberg, G, Ouraou, K, Oyanguren, A, Paganini, A, Paganoni, P, Paiano, M, Pain, S, Paiva, R, Palacios, R, Palka, Jp, Papadopoulou, H, Papageorgiou, Td, Pape, K, Parkes, L, Parodi, C., Parzefall, F, Passeri, U, Passon, A, Pavel, O, Pegoraro, T, Peralta, M, Perepelitsa, L, Pernicka, V, Perrotta, M, Petridou, A, Petrolini, C, Philips, A, Piana, Ht, Piedra, G, Pieri, J, Pierre, L, Pimenta, F, Piotto, M, Podobnik, E, Poireau, T, Pol, V, Polok, Me, Polycarpo, G, Poropat, E, Pozdniakov, P, Privitera, V, Pukhaeva, R, Pullia, N, Radojicic, A, Ragazzi, D, Rahmani, S, Rakoczy, H, Rames, D, Ramler, J, Ratoff, L, Read, Pn, Rebecchi, A, Redaelli, P, Regler, Ng, Rehn, M, Reid, J, Reinhardt, D, Renton, R, Resvanis, P, Richard, Lk, Ridky, F, Rinaudo, J, Ripp, Baudot, Rivero, I, Rodriguez, M, Rohne, D, Romero, O, Ronchese, A, Rosenberg, P, Rosinsky, Ei, Roudeau, P, Rovelli, R, Royon, T, Ruhlmann, Kleider, Ruiz, V, Ryabtchikov, A, Saarikko, D, Sacquin, H, Sadovsky, Y, Sajot, A, Salmi, G, Salt, L, Sampsonidis, J, Sannino, D, Savoy, Navarro, Scheidle, A, Schneider, T, Schwemling, H, Schwering, P, Schwickerath, B, Schyns, U, Mae, Scuri, Seager, F, Sedykh, P, Segar, Y, Seibert, A, Sekulin, N, Shellard, 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Thaler, Fe, Thom, Jj, Trandafir, J, Turk, Ai, Usher, Jd, Vavra, T, Vella, J, Venuti, E, Verdier, Jp, Wagner, R, Waite, Sr, Walston, Ap, Wang, S, Watts, J, Weidemann, Sj, Weiss, Aw, Whitaker, Er, White, Js, Wickens, Sl, Williams, Fj, Williams, Da, Williams, Dc, Willocq, Sh, Wilson, S, Wisniewski, Rj, Wittlin, Wj, Woods, Jl, Word, M, Wright, Gb, Wyss, Tr, Yamamoto, J, Yang, Rk, Yashima, Xq, Yellin, J, Young, Sj, Yuta, Cc, Zapalac, H, Zdarko, G, Zeitlin, Rw, Zhou, C, Blondel, Alain, Schael, S, Barate, R, Bruneliere, R, Spagnolo, Stefania Antonia, S., Schael, Aloisio, Alberto, Alviggi, Mariagrazia, Canale, Vincenzo, Chiefari, Giovanni, DELLA VOLPE, Domenico, Merola, Leonardo, Napolitano, Marco, Patricelli, Sergio, Sciacca, Crisostomo, Lista, Luca, Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Corpusculaire - Clermont-Ferrand (LPC), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Théorique et Astroparticules (LPTA), Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Leprince-Ringuet (LLR), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de l'Accélérateur Linéaire (LAL), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS), Institut de Physique Nucléaire de Lyon (IPNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches Subatomiques (IReS), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Cancéropôle du Grand Est-Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS), Physique Corpusculaire et Cosmologie - Collège de France (PCC), Collège de France (CdF (institution))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), ALEPH, DELPHI, L3, OPAL, SLD, BARBIELLINI AMIDEI, Guido, Bosisio, Luciano, DELLA RICCA, Giuseppe, Giannini, Gianrossano, Gregorio, Anna, Lanceri, Livio, Poropat, Paolo, Vitale, Lorenzo, Buskulic, D, De Bonis, I, Decamp, D, Ghez, P, Goy, C, Jezequel, S, Lees, J, Lucotte, A, Martin, F, Merle, E, Minard, M, Nief, J, Odier, P, Pietrzyk, B, Trocme, B, 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D, Schmitt, B, Schneider, O, Tejessy, W, Teubert, F, Tomalin, I, Tournefier, E, Veenhof, R, Valassi, A, Wiedenmann, W, Wright, A, Ajaltouni, Z, Badaud, F, Chazelle, G, Deschamps, O, Dessagne, S, Falvard, A, Ferdi, C, Fayolle, D, Gay, P, Guicheney, C, Henrard, P, Jousset, J, Michel, B, Monteil, S, Montret, J, Pallin, D, Pascolo, J, Perret, P, Podlyski, F, Bertelsen, H, Fernley, T, Hansen, P, Kraan, A, Lindahl, A, Mollerud, R, Nilsson, B, Rensch, B, Waananen, A, Daskalakis, G, Kyriakis, A, Markou, C, Simopoulou, E, Siotis, I, Vayaki, A, Zachariadou, K, Blondel, A, Bonneaud, G, Brient, J, Machefert, E, Rouge, A, Rumpf, M, Swynghedauw, M, Tanaka, R, Verderi, M, Videau, H, Focardi, E, Parrini, G, Corden, M, Georgiopoulos, C, Antonelli, A, Antonelli, M, Bencivenni, G, Bologna, G, Bossi, F, Campana, P, Capon, G, Chiarella, V, Felici, G, Laurelli, P, Mannocchi, G, Murtas, G, Passalacqua, L, Picchi, P, Colrain, P, Ten Have, I, Hughes, I, Kennedy, J, Knowles, I, Lynch, J, Morton, W, Negus, P, 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ZORN, KENJI ABE, KOYA ABE, T. ABE, I. ABT, P.D. ACTON, I. ADAM, G. AGNEW, T. AKAGI, H. AKIMOTO, N.J. ALLEN, W.W. ASH, D. ASTON, N. BACCHETTA, K.G. BAIRD, C. BALTAY, H.R. BAND, M.B. BARAKAT, G.J. BARANKO, O. BARDON, T.L. BARKLOW, G.L. BASHINDZHAGIAN, R. BATTISTON, J.M. BAUER, A.O. BAZARKO, A. BEAN, G. BELLODI, R. BEN-DAVID, A.C. BENVENUTI, R. BERGER, M. BIASINI, T. BIENZ, G.M. BILEI, D. BISELLO, G. BLAYLOCK, J.R. BOGART, B. BOLEN, T. BOLTON, G.R. BOWER, J.E. BRAU, M. BREIDENBACH, W.M. BUGG, D. BURKE, T.H. BURNETT, P.N. BURROWS, W. BUSZA, A. CALCATERRA, D.O. CALDWELL, B. CAMANZI, M. CARPINELLI, J. CARR, R. CASSELL, R. CASTALDI, A. CASTRO, M. CAVALLI-SFORZA, G.B. CHADWICK, A. CHOU, E. CHURCH, R. CLAUS, H.O. COHN, J.A. COLLER, M.R. CONVERY, V. COOK, R. COTTON, R.F. COWAN, P.A. COYLE, D.G. COYNE, G. CRAWFORD, A. D’OLIVEIRA, C.J.S. DAMERELL, M. DAOUDI, S. DASU, N. DE GROOT, R. DE SANGRO, P. DE SIMONE, S. DE SIMONE, R. DELL’ORSO, P.J. DERVAN, M. DIMA, D.N. DONG, M. DOSER, P.Y.C. DU, R. DUBOIS, J.E. DUBOSCQ, G. EIGEN, B.I. EISENSTEIN, R. ELIA, E. ERDOS, I. EROFEEVA, V. ESCHENBURG, E. ETZION, S. FAHEY, D. FALCIAI, C. FAN, J.P. FERNANDEZ, M.J. FERO, K. FLOOD, R. FREY, J.I. FRIEDMAN, K. FURUNO, E.L. GARWIN, T. GILLMAN, G. GLADDING, S. GONZALEZ, G.D. HALLEWELL, E.L. HART, J.L. HARTON, A. HASAN, Y. HASEGAWA, K. HASUKO, S. HEDGES, S.S. HERTZBACH, M.D. HILDRETH, D.G. HITLIN, A.HONMA, J. S. HUBER, M.E. HUFFER, E.W. HUGHES, X. HUYNH, H.HWANG, M. IWASAKI, Y. IWASAKI, J.M. IZEN, D.J. JACKSON, P. JACQUES, J.A. JAROS, Z.Y. JIANG, A.S. JOHNSON, J.R. JOHNSON, R.A. JOHNSON, T. JUNK, R. KAJIKAWA, M. KALELKAR, Y.A. KAMYSHKOV, H.J. KANG, I. KARLINER, H. KAWAHARA, M.H. KELSEY, H.W. KENDALL, Y.D. KIM, M. KING, R. KING, R. KOFLER, N.M. KRISHNA, Y. KWON, J.F. LABS, R.S. KROEGER, M. LANGSTON, A. LATH, J.A. LAUBER, D.W.G. LEITH, V.LIA, C. LIN, M.X. LIU, M. LORETI, A. LU, H.L. LYNCH, J. MA, G. MANCINELLI, S. MANLY, G. MANTOVANI, T.W. MARKIEWICZ, T. MARUYAMA, H. MASUDA, E. MAZZUCATO, J.F. MCGOWAN, A.K. MCKEMEY, B.T. MEADOWS, R. MESSNER, P.M. MOCKETT, K.C. MOFFEIT, T.B. MOORE, M. MORII, B. MOURS, D. MULLER, G. MUELLER, V. MURZIN, T. NAGAMINE, S. NARITA, U. NAUENBERG, H. NEAL, G. NESOM, M. NUSSBAUM, Y. OHNISHI, N. OISHI, D. ONOPRIENKO, L.S. OSBORNE, R.S. PANVINI, C.H.PARK, H. PARK, T.J. PAVEL, I. PERUZZI, L. PESCARA, M. PICCOLO, L. PIEMONTESE, E. PIERONI, K.T. PITTS, R.J. PLANO, R. PREPOST, C.Y. PRESCOTT, G. PUNKAR, J. QUIGLEY, B.N. RATCLIFF, K. REEVES, T.W. REEVES, J. REIDY, P.L. REINERTSEN, P.E. RENSING, L.S. ROCHESTER, J.E. ROTHBERG, P.C. ROWSON, J.J. RUSSELL, O.H. SAXTON, T. SCHALK, R.H. SCHINDLER, U. SCHNEEKLOTH, B.A. SCHUMM, J. SCHWIENING, A. SEIDEN, S. SEN, V.V. SERBO, L. SERVOLI, M.H. SHAEVITZ, J.T. SHANK, G. SHAPIRO, D.J. SHERDEN, K.D. SHMAKOV, C. SIMOPOULOS, N.B. SINEV, S.R. SMITH, M.B. SMY, J.A. SNYDER, M.D. SOKOLOFF, H. STAENGLE, A. STAHL, P. STAMER, H. STEINER, R. STEINER, M.G. STRAUSS, D. SU, F. SUEKANE, A. SUGIYAMA, A. SUZUKI, S. SUZUKI, M. SWARTZ, A. SZUMILO, T. TAKAHASHI, F.E. TAYLOR, J.J. THALER, J. THOM, E. TORRENCE, A.I. TRANDAFIR, J.D. TURK, T. USHER, J. VA VRA, C. VANNINI, E. VELLA, J.P. VENUTI, R. VERDIER, P.G. VERDINI, D.L. WAGNER, S.R. WAGNER, A.P. WAITE, S. WALSTON, J. WANG, S.J. WATTS, A.W. WEIDEMANN, E.R. WEISS, J.S. WHITAKER, S.L. WHITE, F.J. WICKENS, D.A. WILLIAMS, D.C. WILLIAMS, S.H. WILLIAMS, S. WILLOCQ, R.J. WILSON, W.J. WISNIEWSKI, J.L. WITTLIN, M. WOODS, G.B. WORD, T.R. WRIGHT, J. WYSS, R.K. YAMAMOTO, J.M. YAMARTINO, X.Q. YANG, J. YASHIMA, S.J. YELLIN, C.C.YOUNG, H.YUTA, G. ZAPALAC, R.W. ZDARKO, C. ZEITLIN, J. ZHOU, Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Pierre et Marie Curie - Paris 6 (UPMC), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Laboratoire d'Annecy de Physique des Particules (LAPP/Laboratoire d'Annecy-le-Vieux de Physique des Particules), Centre National de la Recherche Scientifique (CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Aix Marseille Université (AMU), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Collège de France (CdF)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), GRUNEVALD M, NEWALD M, SCHAEL S, BARATE R, BRUNELIE, RE R, BUSKULIC D, DE BONIS I, DECAMP D, GHEZ P, GOY C, JE, ZE, QUEL S, LEES J, LUCOTTE A, MARTIN M, MERLE E, MINARD M, NIEF J, ODIER P, PIETRZYK B, TROCME, BRAVO S, CASADO MP, CHMEISSANI M, COMAS P, CRESPO JM, FERNANDEZ E, FERNANDEZ-BOSMAN M, GARRIDO L, GRAUGES E, JUSTE A, MARTINEZ M, MERINO G, MIQUEL R, MIR LM, ORTEU S, PACHECO A, PARK IC, PERLAS J, RIU I, RUIZ H, SANCHEZ F, COLALEO A, CREANZA D, DE FILIPPIS N, DE PALMA M, IASELLI G, MAGGI G, MAGGI M, NUZZO S, RANIERI, A, RASO, G, RUGGIERI F, SELVAGGI, G, SILVESTRIS L, TEMPESTA P, TRICOMI A, ZITO G, HUANG X, LIN J, OUYANG Q, WANG T, XIE Y, XU R, XUE S, ZHANG J, ZHANG L, ZHAO W, ABBANEO D, BAZARKO A, BECKER U, BOIX G, BIRD F, BLUCHER E, BONVICINI B, BRIGHT-THOMAS P, BARKLOW T, BUCHMU, LLER O, CATTANEO M, CERUTTI F, CIULLI V, CLERBAUX B, DREVERMANN H, FORTY RW, FRANK M, GREENING TC, HAGELBERG R, HALLEY AW, GIANOTTI F, GIRONE M, HANSEN JB, HARVEY J, JACOBSEN J, HUTCHCROFT DE, JANOT P, JOST B, KNOBLOCH J, KADO M, LEHRAUS I, LAZEYRAS P, and MALEY P
Subjects: Top quark, FORWARD-BACKWARD ASYMMETRY, PARTICLE PHYSICS, LARGE ELECTRON POSITRON COLLIDER, ALEPH, DELPHI, L3, OPAL, General Physics and Astronomy, 01 natural sciences, 7. Clean energy, High Energy Physics - Experiment, Settore FIS/04 - Fisica Nucleare e Subnucleare, High Energy Physics - Experiment (hep-ex), High Energy Physics - Phenomenology (hep-ph), electron-positron physics, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], Electroweak interaction, Physics, Quantum chromodynamics, Electron–positron physics, Electroweak interactions, Decays of heavy intermediate gauge bosons, Fermion–antifermion production, Precision measurements at the Z resonance, Tests of the Standard Model, Radiative corrections, Effective coupling constants, Neutral weak current, Z boson, W boson, Higgs boson, Particle physics - Experiment, Settore FIS/01 - Fisica Sperimentale, FERMION-PAIR PRODUCTION, HADRONIC-Z-DECAYS, TOP-QUARK MASS, ANGLE BHABHA SCATTERING, W-BOSON MASS, CROSS-SECTION ASYMMETRY, Z-LINE-SHAPE, SEMILEPTONIC BRANCHING RATIOS, CARLO EVENT GENERATOR, decays of heavy intermediate gauge bosons, effective coupling constants, electroweak interactions, fermion-antifermion production, higgs boson, neutral weak current, precision measurements at the z resonance, radiative corrections, tests of the standard model, top quark, w boson, z boson, Radiative correction, High Energy Physics - Phenomenology, FIS/01 - FISICA SPERIMENTALE, Física nuclear, Neutrino, Particle physics, FOS: Physical sciences, ddc:500.2, Elementary particle physics, LEP, electroweak, Decays of heavy intermediate gauge boson, Effective coupling constant, Partícules (Física nuclear), Standard Model, electroweak theory, Z boson, DELPHI, ALEPH, OPAL, L3, 0103 physical sciences, 010306 general physics, Coupling constant, 010308 nuclear & particles physics, High Energy Physics::Phenomenology, Fermion, FORWARD-BACKWARD ASYMMETRY, FERMION-PAIR PRODUCTION, HADRONIC-Z-DECAYS, TOP-QUARK MASS, ANGLE BHABHA SCATTERING, W-BOSON MASS, CROSS-SECTION ASYMMETRY, Z-LINE-SHAPE, SEMILEPTONIC BRANCHING RATIOS, CARLO EVENT GENERATOR, [PHYS.HPHE]Physics [physics]/High Energy Physics - Phenomenology [hep-ph], Experimental High Energy Physics, Electron–positron physic, High Energy Physics::Experiment, FIS/04 - FISICA NUCLEARE E SUBNUCLEARE
Abstract: We report on the final electroweak measurements performed with data taken at the Z resonance by the experiments operating at the electron-positron colliders SLC and LEP. The data consist of 17 million Z decays accumulated by the ALEPH, DELPHI, L3 and OPAL experiments at LEP, and 600 thousand Z decays by the SLD experiment using a polarised beam at SLC. The measurements include cross-sections, forward-backward asymmetries and polarised asymmetries. The mass and width of the Z boson, $\MZ$ and $\GZ$, and its couplings to fermions, for example the $\rho$ parameter and the effective electroweak mixing angle, are precisely measured. The number of light neutrino species is determined to be 2.9840+/-0.0082. The results are compared to the predictions of the Standard Model. Electroweak radiative corrections beyond the running of the QED and QCD coupling constants are observed with a significance of five standard deviations, and in agreement with the Standard Model. Of the many Z-pole measurements, the forward-backward asymmetry in b-quark production shows the largest difference with respect to its Standard Model expectation, at the level of 2.8 standard deviations. Through radiative corrections evaluated in the framework of the Standard Model, the masses of the top quark and the W Boson are predicted. These indirect constraints are compared to the direct measurements, providing a stringent test of the Standard Model. Using in addition the direct measurements of $\Mt$ and $\MW$, the mass of the as yet unobserved Standard Model Higgs boson is predicted., Comment: 302 pages, v2: minor corrections and updates of references. Accepted for publication by Physics Reports, v3: further small corrections and journal version
Published: 2006

5. Awake Supraglottic Airway Placement in Pediatric Patients for Airway Obstruction or Difficult Intubation: Insights From an International Airway Registry (PeDI).

Author: Longacre M, Park RS, Staffa SJ, Rowland MJ, Meserve J, Lord C, Templeton TW, Garcia-Marcinkiewicz AG, Peyton JM, Fiadjoe JE, Kovatsis PG, and Stein ML
Abstract: Background: Small case series have described awake supraglottic airway placement in infants with significant airway obstruction and difficult intubations. We conducted this study to determine outcomes when supraglottic airways were placed in awake children enrolled in the international Pediatric Difficult Intubation Registry including success of ventilation, success of tracheal intubation, and complications., Methods: We reviewed the Pediatric Difficult Intubation Registry to identify all cases of awake supraglottic airway placement before planned tracheal intubation from August 2012 to September 2023 with subsequent review of details of awake supraglottic airway placement in the medical record. We present descriptive statistics of patient demographics, ventilation and intubation outcomes, and complications., Results: A supraglottic airway was placed in an awake child in 95 of 8061 (1.2%) cases in the Pediatric Difficult Intubation Registry. Median age was 37 days (range 0-17.6 years) and median weight was 3.7 kg (1.6-46.7 kg). Sixteen (17%) cases were in patients older than 2 years and 7 (7%) were in adolescents. Adequate ventilation via a supraglottic airway was achieved in 81/95 (85%, 95% confidence interval [CI], 77%-93%) encounters. Inadequate (n = 13) or impossible (n = 1) ventilation occurred in 14/95 (15%). No complications were reported with supraglottic airway placement. For subsequent intubation, there was a 35% (33/95) first-attempt success rate and 99% (94/95) eventual success, with 1 patient awakened after failed attempts at tracheal intubation. Hypoxia occurred during the first intubation attempt in 9/95 (9%) encounters. The incidence of hypoxia was lower in encounters in which ventilation via the supraglottic airway was adequate (4/81, 5%) than in encounters in which ventilation via the supraglottic airway was inadequate or impossible (5/14, 36%)., Conclusions: Although infrequently attempted, awake placement of a supraglottic airway in children with difficult airways achieved adequate ventilation and provided a conduit for oxygenation and ventilation after induction of anesthesia across a spectrum of ages., Competing Interests: The authors declare no conflicts of interest., (Copyright © 2024 International Anesthesia Research Society.)
Published: 2024
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6. Airway management in the paediatric difficult intubation registry: a propensity score matched analysis of outcomes over time.

Author: Stein ML, Sarmiento Argüello LA, Staffa SJ, Heunis J, Egbuta C, Flynn SG, Khan SA, Sabato S, Taicher BM, Chiao F, Bosenberg A, Lee AC, Adams HD, von Ungern-Sternberg BS, Park RS, Peyton JM, Olomu PN, Hunyady AI, Garcia-Marcinkiewicz A, Fiadjoe JE, and Kovatsis PG
Abstract: Background: The Paediatric Difficult Intubation Collaborative identified multiple attempts and persistence with direct laryngoscopy as risk factors for complications in children with difficult tracheal intubations and subsequently engaged in initiatives to reduce repeated attempts and persistence with direct laryngoscopy in children. We hypothesised these efforts would lead to fewer attempts, fewer direct laryngoscopy attempts and decrease complications., Methods: Paediatric patients less than 18 years of age with difficult direct laryngoscopy were enrolled in the Paediatric Difficult Intubation Registry. We define patients with difficult direct laryngoscopy as those in whom (1) an attending or consultant obtained a Cormack Lehane Grade 3 or 4 view on direct laryngoscopy, (2) limited mouth opening makes direct laryngoscopy impossible, (3) direct laryngoscopy failed in the preceding 6 months, and (4) direct laryngoscopy was deferred due to perceived risk of harm or poor chance of success. We used a 5:1 propensity score match to compare an early cohort from the initial Paediatric Difficult Intubation Registry analysis (August 6, 2012-January 31, 2015, 785 patients, 13 centres) and a current cohort from the Registry (March 4, 2017-March 31, 2023, 3925 patients, 43 centres). The primary outcome was first attempt success rate between cohorts. Success was defined as confirmed endotracheal intubation and assessed by the treating clinician. Secondary outcomes were eventual success rate, number of attempts at intubation, number of attempts with direct laryngoscopy, the incidence of persistence with direct laryngoscopy, use of supplemental oxygen, all complications, and severe complications., Findings: First-attempt success rate was higher in the current cohort (42% vs 32%, OR 1.5 95% CI 1.3-1.8, p < 0.001). In the current cohort, there were fewer attempts (2.2 current vs 2.7 early, regression coefficient -0.5 95% CI -0.6 to -0.4, p < 0.001), fewer attempts with direct laryngoscopy (0.6 current vs 1.0 early, regression coefficient -0.4 95% CI -0.4 to 0.3, p < 0.001), and reduced persistence with direct laryngoscopy beyond two attempts (7.3% current vs 14.1% early, OR 0.5 95% CI 0.4-0.6, p < 0.001). Overall complication rates were similar between cohorts (19% current vs 20% early). Severe complications decreased to 1.8% in the current cohort from 3.2% in the early cohort (OR 0.55 95% CI 0.35-0.87, p = 0.011). Cardiac arrests decreased to 0.8% in the current cohort from 1.8% in the early cohort. We identified persistence with direct laryngoscopy as a potentially modifiable factor associated with severe complications., Interpretation: In the current cohort, children with difficult tracheal intubations underwent fewer intubation attempts, fewer attempts with direct laryngoscopy, and had a nearly 50% reduction in severe complications. As persistence with direct laryngoscopy continues to be associated with severe complications, efforts to limit direct laryngoscopy and promote rapid transition to advanced techniques may enhance patient safety., Funding: None., Competing Interests: Dr. von Ungern-Sternberg’s work is supported by the Stan Perron Charitable Foundation (00058) and through a National Health and Medical Research Council Investigator Grant (2009322) as well as Perth Children’s Hospital Foundation, WA Health Department, Telethon Trust, Australian and New Zeland College of Anaesthetists, Society of Paediatric Anaesthesia NZ/AUS, Thrasher Research Fund, University of Western Australia. Dr. Kovatsis was a medical advisor to Verathon, Inc to December 2020 and Dr. Hunyady is a medical advisor to Verathon, Inc. Dr. Fiadjoe serves in a leadership or fiduciary role for the American Board and Anesthesiology and the Society for Paediatric Anaesthesia. He reports payment or honoraria from Children’s National Hospital and expert testimony for Nemours Foundation. No other external funding or other competing interests declared., (© 2024 The Author(s).)
Published: 2024
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7. Acute Dystonic Reaction After Propofol Administration: A Pediatric Case Report.

Author: Zhao L, McCann ME, Park RS, Pier DB, and Bajic D
Subjects: Female, Humans, Child, Anesthesia, General, Propofol adverse effects, Dystonia chemically induced, Dystonia drug therapy
Abstract: We present a case of a 12-year-old female with a history of infantile spasms who developed a propofol-associated acute dystonic reaction after emergence from general anesthesia for foot surgery. Uniquely, the patient's postoperative symptoms of an acute dystonic reaction were refractory to standard treatment with anticholinergics but were successfully treated with corticosteroids. The absence of any dystonic symptoms following subsequent foot surgery under general anesthesia without propofol supported a propofol-associated etiology. This case may contribute to a better understanding of the underlying mechanisms of propofol-associated acute dystonic reactions and adds a possible new treatment option., Competing Interests: The authors declare no conflicts of interest., (Copyright © 2023 International Anesthesia Research Society.)
Published: 2023
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8. Efficacy of a hybrid technique of simultaneous videolaryngoscopy with flexible bronchoscopy in children with difficult direct laryngoscopy in the Pediatric Difficult Intubation Registry.

Author: Stein ML, Park RS, Kiss EE, Adams HD, Burjek NE, Peyton J, Szmuk P, Staffa SJ, Fiadjoe JE, Kovatsis PG, and Olomu PN
Subjects: Adult, Child, Humans, Bronchoscopy methods, Intubation, Intratracheal methods, Registries, Laryngoscopy methods, Laryngoscopes
Abstract: Children with difficult tracheal intubation are at increased risk of severe complications, including hypoxaemia and cardiac arrest. Increasing experience with the simultaneous use of videolaryngoscopy and flexible bronchoscopy (hybrid) in adults led us to hypothesise that this hybrid technique could be used safely and effectively in children under general anaesthesia. We reviewed observational data from the international Pediatric Difficult Intubation Registry from 2017 to 2021 to assess the safety and efficacy of hybrid tracheal intubation approaches in paediatric patients. In total, 140 patients who underwent 180 attempts at tracheal intubation with the hybrid technique were propensity score-matched 4:1 with 560 patients who underwent 800 attempts with a flexible bronchoscope. In the hybrid group, first attempt success was 70% (98/140) compared with 63% (352/560) in the flexible bronchoscope group (odds ratio (95%CI) 1.4 (0.9-2.1), p = 0.1). Eventual success rates in the matched groups were 90% (126/140) for hybrid vs. 89% (499/560) for flexible bronchoscope (1.1 (0.6-2.1), p = 0.8). Complication rates were similar in both groups (15% (28 complications in 182 attempts) hybrid; 13% (102 complications in 800 attempts) flexible bronchoscope, p = 0.3). The hybrid technique was more likely than flexible bronchoscopy to be used as a rescue technique following the failure of another technique (39% (55/140) vs. 25% (138/560), 2.1 (1.4-3.2) p < 0.001). While technically challenging, the hybrid technique has success rates similar to other advanced airway techniques, few complications and may be considered an alternative technique when developing an airway plan for paediatric patients whose tracheas are difficult to intubate under general anaesthesia., (© 2023 The Authors. Anaesthesia published by John Wiley & Sons Ltd on behalf of Association of Anaesthetists.)
Published: 2023
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9. In the Director's Chair: Screen Time, Coaching, and Intubation in the PICU.

Author: Peyton J, Park RS, Flynn S, and Kovatsis P
Subjects: Humans, Child, Screen Time, Intubation, Intratracheal, Intensive Care Units, Pediatric, Mentoring
Abstract: Competing Interests: Dr. Kovatsis disclosed that he is a medical consultant for Verathon Medical. The remaining authors have disclosed that they do not have any potential conflicts of interest.
Published: 2023
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10. Exploring the Interior of Europa with the Europa Clipper.

Author: Roberts JH, McKinnon WB, Elder CM, Tobie G, Biersteker JB, Young D, Park RS, Steinbrügge G, Nimmo F, Howell SM, Castillo-Rogez JC, Cable ML, Abrahams JN, Bland MT, Chivers C, Cochrane CJ, Dombard AJ, Ernst C, Genova A, Gerekos C, Glein C, Harris CD, Hay HCFC, Hayne PO, Hedman M, Hussmann H, Jia X, Khurana K, Kiefer WS, Kirk R, Kivelson M, Lawrence J, Leonard EJ, Lunine JI, Mazarico E, McCord TB, McEwen A, Paty C, Quick LC, Raymond CA, Retherford KD, Roth L, Rymer A, Saur J, Scanlan K, Schroeder DM, Senske DA, Shao W, Soderlund K, Spiers E, Styczinski MJ, Tortora P, Vance SD, Villarreal MN, Weiss BP, Westlake JH, Withers P, Wolfenbarger N, Buratti B, Korth H, and Pappalardo RT
Abstract: The Galileo mission to Jupiter revealed that Europa is an ocean world. The Galileo magnetometer experiment in particular provided strong evidence for a salty subsurface ocean beneath the ice shell, likely in contact with the rocky core. Within the ice shell and ocean, a number of tectonic and geodynamic processes may operate today or have operated at some point in the past, including solid ice convection, diapirism, subsumption, and interstitial lake formation. The science objectives of the Europa Clipper mission include the characterization of Europa's interior; confirmation of the presence of a subsurface ocean; identification of constraints on the depth to this ocean, and on its salinity and thickness; and determination of processes of material exchange between the surface, ice shell, and ocean. Three broad categories of investigation are planned to interrogate different aspects of the subsurface structure and properties of the ice shell and ocean: magnetic induction, subsurface radar sounding, and tidal deformation. These investigations are supplemented by several auxiliary measurements. Alone, each of these investigations will reveal unique information. Together, the synergy between these investigations will expose the secrets of the Europan interior in unprecedented detail, an essential step in evaluating the habitability of this ocean world., Competing Interests: Competing InterestsThe authors declare that they have no conflicts of interest., (© The Author(s) 2023.)
Published: 2023
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11. The Psyche Magnetometry Investigation.

Author: Weiss BP, Merayo JMG, Ream JB, Oran R, Brauer P, Cochrane CJ, Cloutier K, Elkins-Tanton LT, Jørgensen JL, Maurel C, Park RS, Polanskey CA, de Soria Santacruz-Pich M, Raymond CA, Russell CT, Wenkert D, Wieczorek MA, and Zuber MT
Abstract: The objective of the Psyche Magnetometry Investigation is to test the hypothesis that asteroid (16) Psyche formed from the core of a differentiated planetesimal. To address this, the Psyche Magnetometer will measure the magnetic field around the asteroid to search for evidence of remanent magnetization. Paleomagnetic measurements of meteorites and dynamo theory indicate that a diversity of planetesimals once generated dynamo magnetic fields in their metallic cores. Likewise, the detection of a strong magnetic moment ( > 2 × 10 14 Am 2 ) at Psyche would likely indicate that the body once generated a core dynamo, implying that it formed by igneous differentiation. The Psyche Magnetometer consists of two three-axis fluxgate Sensor Units (SUs) mounted 0.7 m apart along a 2.15-m long boom and connected to two Electronics Units (EUs) located within the spacecraft bus. The Magnetometer samples at up to 50 Hz, has a range of ± 80 , 000 nT , and an instrument noise of 39 pT axis - 1 3 σ integrated over 0.1 to 1 Hz. The two pairs of SUs and EUs provide redundancy and enable gradiometry measurements to suppress noise from flight system magnetic fields. The Magnetometer will be powered on soon after launch and acquire data for the full duration of the mission. The ground data system processes the Magnetometer measurements to obtain an estimate of Psyche's dipole moment., Competing Interests: Competing InterestsThe authors declare no competing interests., (© The Author(s) 2023.)
Published: 2023
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12. Practice Guidelines for Difficult Airway Management: Comment.

Author: Stein ML, Bunten E, Butler CG, Egbuta C, Flynn S, Kovatsis PG, Nargozian CD, Park RS, and Peyton JM
Subjects: Respiratory System, Thorax, Airway Management, Intubation, Intratracheal
Published: 2022
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13. Juno spacecraft gravity measurements provide evidence for normal modes of Jupiter.

Author: Durante D, Guillot T, Iess L, Stevenson DJ, Mankovich CR, Markham S, Galanti E, Kaspi Y, Zannoni M, Gomez Casajus L, Lari G, Parisi M, Buccino DR, Park RS, and Bolton SJ
Abstract: The Juno spacecraft has been collecting data to shed light on the planet's origin and characterize its interior structure. The onboard gravity science experiment based on X-band and Ka-band dual-frequency Doppler tracking precisely measured Jupiter's zonal gravitational field. Here, we analyze 22 Juno's gravity passes to investigate the gravity field. Our analysis provides evidence of new gravity field features, which perturb its otherwise axially symmetric structure with a time-variable component. We show that normal modes of the planet could explain the anomalous signatures present in the Doppler data better than other alternative explanations, such as localized density anomalies and non-axisymmetric components of the static gravity field. We explain Juno data by p-modes having an amplitude spectrum with a peak radial velocity of 10-50 cm/s at 900-1200 μHz (compatible with ground-based observations) and provide upper bounds on lower frequency f-modes (radial velocity smaller than 1 cm/s). The new Juno results could open the possibility of exploring the interior structure of the gas giants through measurements of the time-variable gravity or with onboard instrumentation devoted to the observation of normal modes, which could drive spacecraft operations of future missions., (© 2022. The Author(s).)
Published: 2022
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14. Distinguishing the Origin of Asteroid (16) Psyche.

Author: Elkins-Tanton LT, Asphaug E, Bell JF 3rd, Bierson CJ, Bills BG, Bottke WF, Courville SW, Dibb SD, Jun I, Lawrence DJ, Marchi S, McCoy TJ, Merayo JMG, Oran R, O'Rourke JG, Park RS, Peplowski PN, Prettyman TH, Raymond CA, Weiss BP, Wieczorek MA, and Zuber MT
Abstract: The asteroid (16) Psyche may be the metal-rich remnant of a differentiated planetesimal, or it may be a highly reduced, metal-rich asteroidal material that never differentiated. The NASA Psyche mission aims to determine Psyche's provenance. Here we describe the possible solar system regions of origin for Psyche, prior to its likely implantation into the asteroid belt, the physical and chemical processes that can enrich metal in an asteroid, and possible meteoritic analogs. The spacecraft payload is designed to be able to discriminate among possible formation theories. The project will determine Psyche's origin and formation by measuring any strong remanent magnetic fields, which would imply it was the core of a differentiated body; the scale of metal to silicate mixing will be determined by both the neutron spectrometers and the filtered images; the degree of disruption between metal and rock may be determined by the correlation of gravity with composition; some mineralogy (e.g., modeled silicate/metal ratio, and inferred existence of low-calcium pyroxene or olivine, for example) will be detected using filtered images; and the nickel content of Psyche's metal phase will be measured using the GRNS., Competing Interests: Conflict of InterestNot applicable., (© The Author(s) 2022.)
Published: 2022
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15. Lessons from COVID-19: A reflection on the strengths and weakness of early consensus recommendations for pediatric difficult airway management during a respiratory viral pandemic using a modified Delphi method.

Author: Stein ML, Park RS, Afshari A, Disma N, Fiadjoe JE, Matava CT, McNarry AF, von Ungern-Sternberg BS, Kovatsis PG, and Peyton JM
Subjects: Airway Management, Child, Consensus, Humans, Intubation, Intratracheal, SARS-CoV-2, COVID-19, Pandemics
Abstract: Background: The authors recognized a gap in existing guidelines and convened a modified Delphi process to address novel issues in pediatric difficult airway management raised by the COVID-19 pandemic., Methods: The Pediatric Difficult Intubation Collaborative, a working group of the Society for Pediatric Anesthesia, assembled an international panel to reach consensus recommendations on pediatric difficult airway management during the COVID-19 pandemic using a modified Delphi method. We reflect on the strengths and weaknesses of this process and ways care has changed as knowledge and experience have grown over the course of the pandemic., Recommendations: In the setting of the COVID-19 pandemic, the Delphi panel recommends against moving away from the operating room solely for the purpose of having a negative pressure environment. The Delphi panel recommends supplying supplemental oxygen and using videolaryngoscopy during anticipated difficult airway management. Direct laryngoscopy is not recommended. If the patient meets extubation criteria, extubate in the OR, awake, at the end of the procedure., Reflection: These recommendations remain valuable guidance in caring for children with anticipated difficult airways and infectious respiratory pathology when reviewed in light of our growing knowledge and experience with COVID-19. The panel initially recommended minimizing involvement of additional people and trainees and minimizing techniques associated with aerosolization of viral particles. The demonstrated effectiveness of PPE and vaccination at reducing the risk of exposure and infection to clinicians managing the airway makes these recommendations less relevant for COVID-19. They would likely be important initial steps in the face of novel respiratory viral pathogens., Conclusions: The consensus process cannot and should not replace evidence-based guidelines; however, it is encouraging to see that the panel's recommendations have held up well as scientific knowledge and clinical experience have grown., (© 2021 John Wiley & Sons Ltd.)
Published: 2021
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16. The synergistic effect of dexmedetomidine on propofol for paediatric deep sedation: A randomised trial.

Author: Mason KP, Park RS, Sullivan CA, Lukovits K, Halpin EM, Imbrescia ST, Cavanaugh D, Prescilla R, and Fox VL
Subjects: Adult, Child, Humans, Hypnotics and Sedatives, Prospective Studies, Deep Sedation, Dexmedetomidine adverse effects, Propofol
Abstract: Background: Propofol and dexmedetomidine are used separately, and sometimes together, for paediatric deep sedation. Although their combination has been described in adults, the effect of dexmedetomidine as a potential synergist in children has not been studied before., Objectives: The primary objective was to compare the propofol requirements of children who receive propofol alone with those who receive it in combination with dexmedetomidine for deep sedation for upper and lower endoscopic gastrointestinal procedures., Design: This was a prospective, open-label, randomised study comparing patients who received propofol alone (group P) with those who received dexmedetomidine and propofol (group DP). The depth of sedation was titrated to a target bispectral (BIS) index., Setting: A Gastroenterology Procedure Unit at a single, tertiary care academic medical centre from April 2018 until December 2019., Patients: Eligible patients were scheduled for upper endoscopy, lower endoscopy or both. A total of 39 patients were enrolled (20 DP) and (19 P)., Interventions: Patients in Group DP received dexmedetomidine 0.5 μg kg-1 administered over 1 min followed by an infusion of 0.15 μg kg-1 h-1. In both groups, intravenous propofol was given in bolus increments titrated to a BIS index of 40 to 50 and then a continuous infusion of propofol to maintain BIS at 40 to 50., Main Outcome Measures: The primary outcome measure was propofol requirement in each group. Secondary outcome measures were time to achieve the targeted sedation depth, time to achieve an Aldrete recovery score of 9, duration of sedation, mean BIS values, adverse events, 'PAED' scores and time to discharge from the postanaesthesia care unit (PACU)., Results: The median (range) total dose of propofol was 0.23 (0.10 to 0.50) mg kg-1 min-1 in group DP and 0.40 (0.20 to 0.50) mg kg-1 min-1 in group P (P = 0.0004). Time of discharge from the PACU was 60 (20 to 121) min in group DP and 63 (46 to 91) min in group P (P = 0.0409)., Conclusion: The combination of dexmedetomidine and propofol for paediatric procedural sedation achieved a significant reduction in median propofol dose and a slightly shorter median time to discharge from PACU. Large-scale studies may determine whether this reduction decreases the risk of significant adverse events., Trial Registration: ClinicalTrials.gov identifier NCT02952222., (Copyright © 2020 European Society of Anaesthesiology and Intensive Care. Unauthorized reproduction of this article is prohibited.)
Published: 2021
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17. Aerosol barriers in pediatric anesthesiology: Clinical data supports FDA caution.

Author: Tighe NTG, McClain CD, Vlassakova BG, Cravero JP, Peyton JM, Kovatsis PG, Park RS, and Stein ML
Subjects: Adolescent, Aerosols, Child, Child, Preschool, Female, Humans, Infant, Male, SARS-CoV-2, United States, Airway Management methods, Anesthesiology methods, COVID-19 prevention & control, Infection Control methods, Pediatrics, United States Food and Drug Administration
Abstract: Background: The onset of the COVID19 pandemic drove the rapid development and adoption of physical barriers intended to protect providers from aerosols generated during airway management. We report our initial experience with aerosol barrier devices in pediatric patients and raise concerns that they may increase risk to patients., Methods: In March 2020, we developed and implemented simulation training and use of plastic aerosol barrier devices as a component of our perioperative COVID-19 workflow. As part of our quality improvement process, we obtained detailed feedback via a web-based survey after cases were performed while using these aerosol barriers., Results: Between March and June 2020, 36 pediatric patients age 1mo-18years with anatomically normal airways and either PCR confirmed or suspected COVID-19 were intubated under an aerosol barrier as part of urgent or emergent anesthetic care at our institution. Experienced providers had more difficulty than expected in six (16.7%) of the cases with four cases requiring multiple attempts to secure the airway and two cases involving pronounced difficulty in a single attempt. The aerosol barrier was perceived as a contributing factor to difficulty in all cases., Conclusion: The use of barriers may result in unanticipated difficulties with airway management, particularly in pediatric patients, which could lead to hypoxemia or other patient harm. Our initial experience in pediatric patients is the first such report in patients and provides clinical data which corroborates the simulation data prompting the FDA to withdraw support of barriers., (© 2020 John Wiley & Sons Ltd.)
Published: 2021
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18. Risk of Hypoxemia by Induction Technique Among Infants and Neonates Undergoing Pyloromyotomy.

Author: Park RS, Rattana-Arpa S, Peyton JM, Huang J, Kordun A, Cravero JP, Zurakowski D, and Kovatsis PG
Subjects: Biomarkers blood, Female, Humans, Hypoxia blood, Hypoxia diagnosis, Infant, Infant, Newborn, Male, Retrospective Studies, Risk Assessment, Risk Factors, Treatment Outcome, Anesthesia, General, Hypoxia etiology, Oxygen blood, Pyloromyotomy, Rapid Sequence Induction and Intubation adverse effects
Abstract: Background: In patients presenting for pyloromyotomy, most practitioners prioritize rapid securement of the airway due to concern for aspiration. However, there is a lack of consensus and limited evidence on the choice between rapid sequence induction (RSI) and modified RSI (mRSI)., Methods: The medical records of all patients presenting for pyloromyotomy from May 2012 to December 2018 were reviewed. The risk of hypoxemia (peripheral oxygen saturation [Spo2], <90%) during induction was compared between RSI and mRSI cohorts for all patients identified as well as in the neonate subgroup by univariate and multivariable logistic regression analysis. Complications (aspiration, intensive care unit admission, bradycardia, postoperative stridor, and hypotension) and initial intubation success for both cohorts were also compared., Results: A total of 296 patients were identified: 181 in the RSI and 115 in the mRSI cohorts. RSI was associated with significantly higher rates of hypoxemia than mRSI (RSI, 30% [23%-37%]; mRSI, 17% [10%-24%]; P = .016). In multivariable logistic regression analysis of all patients, the adjusted odds ratio (OR) of hypoxemia for RSI versus mRSI was 2.8 (95% confidence interval [CI], 1.5-5.3; P = .003) and the OR of hypoxemia for multiple versus a single intubation attempt was 11.4 (95% CI, 5.8-22.5; P < .001). In multivariable logistic regression analysis of neonatal subgroup, the OR of hypoxemia for RSI versus mRSI was 6.5 (95% CI, 2.0-22.2; P < .001) and the OR of hypoxemia for multiple intubation versus single intubation attempts was 18.1 (95% CI, 4.7-40; P < .001). There were no induction-related complications in either the RSI and mRSI cohorts, and the initial intubation success rate was identical for both cohorts (78%)., Conclusions: In infants presenting for pyloromyotomy, anesthetic induction with mRSI compared with RSI was associated with significantly less hypoxemia without an observed increase in aspiration events. In addition, the need for multiple intubation attempts was a strong predictor of hypoxemia. The increased risk of hypoxemia associated with RSI and multiple intubation attempts was even more pronounced in neonatal patients., Competing Interests: Conflicts of Interest: See Disclosures at the end of the article., (Copyright © 2019 International Anesthesia Research Society.)
Published: 2021
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19. Heterogeneous mass distribution of the rubble-pile asteroid (101955) Bennu.

Author: Scheeres DJ, French AS, Tricarico P, Chesley SR, Takahashi Y, Farnocchia D, McMahon JW, Brack DN, Davis AB, Ballouz RL, Jawin ER, Rozitis B, Emery JP, Ryan AJ, Park RS, Rush BP, Mastrodemos N, Kennedy BM, Bellerose J, Lubey DP, Velez D, Vaughan AT, Leonard JM, Geeraert J, Page B, Antreasian P, Mazarico E, Getzandanner K, Rowlands D, Moreau MC, Small J, Highsmith DE, Goossens S, Palmer EE, Weirich JR, Gaskell RW, Barnouin OS, Daly MG, Seabrook JA, Al Asad MM, Philpott LC, Johnson CL, Hartzell CM, Hamilton VE, Michel P, Walsh KJ, Nolan MC, and Lauretta DS
Abstract: The gravity field of a small body provides insight into its internal mass distribution. We used two approaches to measure the gravity field of the rubble-pile asteroid (101955) Bennu: (i) tracking and modeling the spacecraft in orbit about the asteroid and (ii) tracking and modeling pebble-sized particles naturally ejected from Bennu's surface into sustained orbits. These approaches yield statistically consistent results up to degree and order 3, with the particle-based field being statistically significant up to degree and order 9. Comparisons with a constant-density shape model show that Bennu has a heterogeneous mass distribution. These deviations can be modeled with lower densities at Bennu's equatorial bulge and center. The lower-density equator is consistent with recent migration and redistribution of material. The lower-density center is consistent with a past period of rapid rotation, either from a previous Yarkovsky-O'Keefe-Radzievskii-Paddack cycle or arising during Bennu's accretion following the disruption of its parent body., (Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).)
Published: 2020
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20. The Use of Bispectral Index Monitoring Does Not Change Intraoperative Exposure to Volatile Anesthetics in Children.

Author: Sullivan CA, Egbuta C, Park RS, Lukovits K, Cavanaugh D, and Mason KP
Abstract: The exposure of infants and children to volatile anesthetics, such as sevoflurane, has been a topic of concern with respect to the potential risk for long term neurocognitive effects. The primary objective of this study was to determine whether the perioperative utilization of Bispectral Index (BIS) monitoring alters the sevoflurane delivery and exposure to children. This is a prospective randomized trial of two groups of healthy ambulatory day surgery patients (2 to 12 years). The patients in both groups had the BIS applied soon after the induction of general anesthesia, but only the anesthesiologists in the group randomized to BIS visible were able to see the BIS values. All of the patients received general anesthesia with sevoflurane. This study found no difference in the overall exposure to sevoflurane between both groups (mean end-tidal sevoflurane level of 1.8 in both groups, P = 084). The duration of time in the recovery room, the time to meet discharge criteria, the Pediatric Agitation Emergence Delirium (PAED) scores and the Face, Legs, Activity, Cry, Consolability (FLACC) scores were not statistically different between the groups. The application and utilization of intraoperative BIS monitoring does not alter the sevoflurane administration nor the discharge readiness nor the recovery profile in healthy ambulatory children.
Published: 2020
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21. Emerging trends, techniques, and equipment for airway management in pediatric patients.

Author: Stein ML, Park RS, and Kovatsis PG
Subjects: Airway Management trends, Child, Humans, Pediatrics trends, Airway Management instrumentation, Airway Management methods, Pediatrics instrumentation, Pediatrics methods
Abstract: Pediatric patients present unique anatomic and physiologic considerations in airway management, which impose significant physiologic limits on safe apnea time before the onset of hypoxemia and subsequent bradycardia. These issues are even more pronounced for the pediatric difficult airway. In the last decade, the development of pediatric sized supraglottic airways specifically designed for intubation, as well as advances in imaging technology such that current pediatric airway equipment now finally rival those for the adult population, has significantly expanded the pediatric anesthesiologist's tool kit for pediatric airway management. Equally important, techniques are increasingly implemented that maintain oxygen delivery to the lungs, safely extending the time available for pediatric airway management. This review will focus on emerging trends and techniques using existing tools to safely handle the pediatric airway including videolaryngoscopy, combination techniques for intubation, techniques for maintaining oxygenation during intubation, airway management in patients at risk for aspiration, and considerations in cannot intubate cannot oxygenate scenarios., (© 2019 John Wiley & Sons Ltd.)
Published: 2020
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22. Neonatal Airway Management.

Author: Park RS, Peyton JM, and Kovatsis PG
Subjects: Airway Management methods, Humans, Infant, Newborn, Infant, Premature, Laryngeal Masks, Larynx anatomy & histology, Lung Compliance physiology, Masks, Mouth anatomy & histology, Neuromuscular Blockade methods, Noninvasive Ventilation methods, Pharynx anatomy & histology, Skull anatomy & histology, Tongue anatomy & histology, Hypnotics and Sedatives therapeutic use, Intubation, Intratracheal methods, Laryngoscopy methods
Abstract: Safe and effective airway management of neonates requires unique knowledge and clinical skills. Practitioners should have an understanding of neonatal airway anatomy and respiratory physiology and their clinical implications related to airway management. It is vital to recognize the potential sequelae of prematurity. Clinicians should be familiar with the skills and techniques available for managing normal neonatal airways. This review provides stepwise considerations for managing the neonatal airway: specific considerations for neonatal airway management, assessment and preparation, induction and premedication, and techniques and strategies for airway management in patients with normal anatomy and in patients who are difficult to intubate., (Copyright © 2019 Elsevier Inc. All rights reserved.)
Published: 2019
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23. Three-dimensional integration of nanotechnologies for computing and data storage on a single chip.

Author: Shulaker MM, Hills G, Park RS, Howe RT, Saraswat K, Wong HP, and Mitra S
Abstract: The computing demands of future data-intensive applications will greatly exceed the capabilities of current electronics, and are unlikely to be met by isolated improvements in transistors, data storage technologies or integrated circuit architectures alone. Instead, transformative nanosystems, which use new nanotechnologies to simultaneously realize improved devices and new integrated circuit architectures, are required. Here we present a prototype of such a transformative nanosystem. It consists of more than one million resistive random-access memory cells and more than two million carbon-nanotube field-effect transistors-promising new nanotechnologies for use in energy-efficient digital logic circuits and for dense data storage-fabricated on vertically stacked layers in a single chip. Unlike conventional integrated circuit architectures, the layered fabrication realizes a three-dimensional integrated circuit architecture with fine-grained and dense vertical connectivity between layers of computing, data storage, and input and output (in this instance, sensing). As a result, our nanosystem can capture massive amounts of data every second, store it directly on-chip, perform in situ processing of the captured data, and produce 'highly processed' information. As a working prototype, our nanosystem senses and classifies ambient gases. Furthermore, because the layers are fabricated on top of silicon logic circuitry, our nanosystem is compatible with existing infrastructure for silicon-based technologies. Such complex nano-electronic systems will be essential for future high-performance and highly energy-efficient electronic systems.
Published: 2017
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24. Hysteresis-Free Carbon Nanotube Field-Effect Transistors.

Author: Park RS, Hills G, Sohn J, Mitra S, Shulaker MM, and Wong HP
Abstract: While carbon nanotube (CNT) field-effect transistors (CNFETs) promise high-performance and energy-efficient digital systems, large hysteresis degrades these potential CNFET benefits. As hysteresis is caused by traps surrounding the CNTs, previous works have shown that clean interfaces that are free of traps are important to minimize hysteresis. Our previous findings on the sources and physics of hysteresis in CNFETs enabled us to understand the influence of gate dielectric scaling on hysteresis. To begin with, we validate through simulations how scaling the gate dielectric thickness results in greater-than-expected benefits in reducing hysteresis. Leveraging this insight, we experimentally demonstrate reducing hysteresis to <0.5% of the gate-source voltage sweep range using a very large-scale integration compatible and solid-state technology, simply by fabricating CNFETs with a thin effective oxide thickness of 1.6 nm. However, even with negligible hysteresis, large subthreshold swing is still observed in the CNFETs with multiple CNTs per transistor. We show that the cause of large subthreshold swing is due to threshold voltage variation between individual CNTs. We also show that the source of this threshold voltage variation is not explained solely by variations in CNT diameters (as is often ascribed). Rather, other factors unrelated to the CNTs themselves (i.e., process variations, random fixed charges at interfaces) are a significant factor in CNT threshold voltage variations and thus need to be further improved.
Published: 2017
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25. In-Situ Catalytic Pyrolysis of Dealkaline Lignin Over MMZ-Hβ.

Author: Kim JM, Park RS, Lee EH, Jeon JK, Kim SC, Jung SC, Kim S, and Park YK
Abstract: In-Situ catalytic pyrolysis of dealkaline lignin (DL) over MMZ-Hβ was performed using a pyrolyzergas chromatography/mass spectroscopy for the first time. Non-catalytic pyrolysis of DL mainly produced large amounts of phenolics such as mono-phenol, alkylphenols, guaiacols, eugenols, and vanillin. By applying MMZ-Hβ, the amounts of these phenolics were dramatically decreased with the increase of aromatics such as benzene, toluene, ethylbenzene, xylenes, and naphthalenes. The higher conversion efficiency from phenolics to aromatics was obtained by increasing the catalyst to DL ratio from 1/1 to 5/1.
Published: 2017
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26. Catalytic Pyrolysis of Cork Oak Over Supercritical Hydrothermal Synthesized Nanosized ZrO₂.

Author: Lee Y, Park RS, Hong Y, Lee H, Park SH, Jung SC, Kim SC, Jeon JK, and Park YK
Abstract: The change in acidity of pyrolysis bio-oil was investigated using the catalytic pyrolysis of cork oak over zirconia synthesized by supercritical hydrothermal synthesis using a fixed bed reactor. Catalytic pyrolysis over zirconia reduced the content of acetic acid considerably and showed high selectivity to ketones and high-value-added aromatic compounds.
Published: 2017
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27. Gravity field of the Orientale basin from the Gravity Recovery and Interior Laboratory Mission.

Author: Zuber MT, Smith DE, Neumann GA, Goossens S, Andrews-Hanna JC, Head JW, Kiefer WS, Asmar SW, Konopliv AS, Lemoine FG, Matsuyama I, Melosh HJ, McGovern PJ, Nimmo F, Phillips RJ, Solomon SC, Taylor GJ, Watkins MM, Wieczorek MA, Williams JG, Jansen JC, Johnson BC, Keane JT, Mazarico E, Miljković K, Park RS, Soderblom JM, and Yuan DN
Abstract: The Orientale basin is the youngest and best-preserved major impact structure on the Moon. We used the Gravity Recovery and Interior Laboratory (GRAIL) spacecraft to investigate the gravitational field of Orientale at 3- to 5-kilometer (km) horizontal resolution. A volume of at least (3.4 ± 0.2) × 10 6 km 3 of crustal material was removed and redistributed during basin formation. There is no preserved evidence of the transient crater that would reveal the basin's maximum volume, but its diameter may now be inferred to be between 320 and 460 km. The gravity field resolves distinctive structures of Orientale's three rings and suggests the presence of faults associated with the outer two that penetrate to the mantle. The crustal structure of Orientale provides constraints on the formation of multiring basins., (Copyright © 2016, American Association for the Advancement of Science.)
Published: 2016
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28. A partially differentiated interior for (1) Ceres deduced from its gravity field and shape.

Author: Park RS, Konopliv AS, Bills BG, Rambaux N, Castillo-Rogez JC, Raymond CA, Vaughan AT, Ermakov AI, Zuber MT, Fu RR, Toplis MJ, Russell CT, Nathues A, and Preusker F
Abstract: Remote observations of the asteroid (1) Ceres from ground- and space-based telescopes have provided its approximate density and shape, leading to a range of models for the interior of Ceres, from homogeneous to fully differentiated. A previously missing parameter that can place a strong constraint on the interior of Ceres is its moment of inertia, which requires the measurement of its gravitational variation together with either precession rate or a validated assumption of hydrostatic equilibrium. However, Earth-based remote observations cannot measure gravity variations and the magnitude of the precession rate is too small to be detected. Here we report gravity and shape measurements of Ceres obtained from the Dawn spacecraft, showing that it is in hydrostatic equilibrium with its inferred normalized mean moment of inertia of 0.37. These data show that Ceres is a partially differentiated body, with a rocky core overlaid by a volatile-rich shell, as predicted in some studies. Furthermore, we show that the gravity signal is strongly suppressed compared to that predicted by the topographic variation. This indicates that Ceres is isostatically compensated, such that topographic highs are supported by displacement of a denser interior. In contrast to the asteroid (4) Vesta, this strong compensation points to the presence of a lower-viscosity layer at depth, probably reflecting a thermal rather than compositional gradient. To further investigate the interior structure, we assume a two-layer model for the interior of Ceres with a core density of 2,460-2,900 kilograms per cubic metre (that is, composed of CI and CM chondrites), which yields an outer-shell thickness of 70-190 kilometres. The density of this outer shell is 1,680-1,950 kilograms per cubic metre, indicating a mixture of volatiles and denser materials such as silicates and salts. Although the gravity and shape data confirm that the interior of Ceres evolved thermally, its partially differentiated interior indicates an evolution more complex than has been envisioned for mid-sized (less than 1,000 kilometres across) ice-rich rocky bodies.
Published: 2016
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29. Dawn arrives at Ceres: Exploration of a small, volatile-rich world.

Author: Russell CT, Raymond CA, Ammannito E, Buczkowski DL, De Sanctis MC, Hiesinger H, Jaumann R, Konopliv AS, McSween HY, Nathues A, Park RS, Pieters CM, Prettyman TH, McCord TB, McFadden LA, Mottola S, Zuber MT, Joy SP, Polanskey C, Rayman MD, Castillo-Rogez JC, Chi PJ, Combe JP, Ermakov A, Fu RR, Hoffmann M, Jia YD, King SD, Lawrence DJ, Li JY, Marchi S, Preusker F, Roatsch T, Ruesch O, Schenk P, Villarreal MN, and Yamashita N
Abstract: On 6 March 2015, Dawn arrived at Ceres to find a dark, desiccated surface punctuated by small, bright areas. Parts of Ceres' surface are heavily cratered, but the largest expected craters are absent. Ceres appears gravitationally relaxed at only the longest wavelengths, implying a mechanically strong lithosphere with a weaker deep interior. Ceres' dry exterior displays hydroxylated silicates, including ammoniated clays of endogenous origin. The possibility of abundant volatiles at depth is supported by geomorphologic features such as flat crater floors with pits, lobate flows of materials, and a singular mountain that appears to be an extrusive cryovolcanic dome. On one occasion, Ceres temporarily interacted with the solar wind, producing a bow shock accelerating electrons to energies of tens of kilovolts., (Copyright © 2016, American Association for the Advancement of Science.)
Published: 2016
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30. Cratering on Ceres: Implications for its crust and evolution.

Author: Hiesinger H, Marchi S, Schmedemann N, Schenk P, Pasckert JH, Neesemann A, O'Brien DP, Kneissl T, Ermakov AI, Fu RR, Bland MT, Nathues A, Platz T, Williams DA, Jaumann R, Castillo-Rogez JC, Ruesch O, Schmidt B, Park RS, Preusker F, Buczkowski DL, Russell CT, and Raymond CA
Abstract: Thermochemical models have predicted that Ceres, is to some extent, differentiated and should have an icy crust with few or no impact craters. We present observations by the Dawn spacecraft that reveal a heavily cratered surface, a heterogeneous crater distribution, and an apparent absence of large craters. The morphology of some impact craters is consistent with ice in the subsurface, which might have favored relaxation, yet large unrelaxed craters are also present. Numerous craters exhibit polygonal shapes, terraces, flowlike features, slumping, smooth deposits, and bright spots. Crater morphology and simple-to-complex crater transition diameters indicate that the crust of Ceres is neither purely icy nor rocky. By dating a smooth region associated with the Kerwan crater, we determined absolute model ages (AMAs) of 550 million and 720 million years, depending on the applied chronology model., (Copyright © 2016, American Association for the Advancement of Science.)
Published: 2016
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31. Hysteresis in Carbon Nanotube Transistors: Measurement and Analysis of Trap Density, Energy Level, and Spatial Distribution.

Author: Park RS, Shulaker MM, Hills G, Suriyasena Liyanage L, Lee S, Tang A, Mitra S, and Wong HS
Abstract: We present a measurement technique, which we call the Pulsed Time-Domain Measurement, for characterizing hysteresis in carbon nanotube field-effect transistors, and demonstrate its applicability for a broad range of 1D and 2D nanomaterials beyond carbon nanotubes. The Pulsed Time-Domain Measurement enables the quantification (density, energy level, and spatial distribution) of charged traps responsible for hysteresis. A physics-based model of the charge trapping process for a carbon nanotube field-effect transistor is presented and experimentally validated using the Pulsed Time-Domain Measurement. Leveraging this model, we discover a source of traps (surface traps) unique to devices with low-dimensional channels such as carbon nanotubes and nanowires (beyond interface traps which exist in today's silicon field-effect transistors). The different charge trapping mechanisms for interface traps and surface traps are studied based on their temperature dependencies. Through these advances, we are able to quantify the interface trap density for carbon nanotube field-effect transistors (∼3 × 10(13) cm(-2) eV(-1) near midgap), and compare this against a range of previously studied dielectric/semiconductor interfaces.
Published: 2016
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32. HER2 as a target in invasive urothelial carcinoma.

Author: Bellmunt J, Werner L, Bamias A, Fay AP, Park RS, Riester M, Selvarajah S, Barletta JA, Berman DM, de Muga S, Salido M, Gallardo E, Rojo F, Guancial EA, Bambury R, Mullane SA, Choueiri TK, Loda M, Stack E, and Rosenberg J
Subjects: Clinical Trials, Phase III as Topic, Cohort Studies, DNA Copy Number Variations genetics, Humans, Immunohistochemistry, In Situ Hybridization, Fluorescence, Neoplasm Metastasis, Observer Variation, RNA, Messenger genetics, RNA, Messenger metabolism, Receptor, ErbB-2 genetics, Survival Analysis, Urinary Bladder Neoplasms drug therapy, Mutation genetics, Receptor, ErbB-2 metabolism, Urinary Bladder Neoplasms genetics
Abstract: We evaluated primary tumors from two cohorts, Spain (N = 111) and Greece (N = 102), for patients who were treated with platinum-based chemotherapy. Patients were tested for HER2 status (IHC score of 3+ or FISH ratio of ≥ 2.2) by immunohistochemistry (IHC), fluorescence in situ hybridization (FISH), DNA copy number, mRNA expression, and mutation status in patients with metastatic urothelial carcinoma (UC), and its impact on survival. ERBB2 mutation was determined by hotspot sequencing. mRNA expression was assessed using NanoString counting. Association of overall survival (OS) and HER2 status was assessed by a Cox regression model. NIH-3T3 cells containing HER2 V777L were assessed for growth, invasion, and HER2 kinase activation. In all, 22% of Spanish and 4% of Greek cohorts had 3+ HER2 staining by IHC. FISH amplification was identified in 20% of Spanish and 4% of Greek cohorts. Kappa coefficient between FISH and IHC was 0.47. HER2 status was not associated with OS in univariate (Spanish P = 0.34; Greek P = 0.11) or multivariate (Spanish P = 0.49; Greek P = 0.12) analysis. HER2-positive tumors expressed higher levels of HER2 mRNA than HER2-negative tumors (P < 0.001). HER2 mutations (V777L and L755S) were identified in two (2%) patients. In vitro analysis of V777L results in transformation of NIH-3T3 cells, leading to increased growth, invasion on soft agar, and HER2 kinase constitutive activation. In summary, HER2 overexpression or amplification in the primary tumor did not predict OS in patients with metastatic UC. HER2 positivity rates can differ between different populations. Further trials in genomically screened patients are needed to assess HER2-targeted therapies in UC., (© 2015 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.)
Published: 2015
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33. FGFR3 expression in primary and metastatic urothelial carcinoma of the bladder.

Author: Guancial EA, Werner L, Bellmunt J, Bamias A, Choueiri TK, Ross R, Schutz FA, Park RS, O'Brien RJ, Hirsch MS, Barletta JA, Berman DM, Lis R, Loda M, Stack EC, Garraway LA, Riester M, Michor F, Kantoff PW, and Rosenberg JE
Subjects: Carcinoma, Transitional Cell mortality, Carcinoma, Transitional Cell secondary, Gene Dosage, Gene Expression, Humans, Kaplan-Meier Estimate, Mutation, Missense, Proportional Hazards Models, RNA, Messenger genetics, RNA, Messenger metabolism, Receptor, Fibroblast Growth Factor, Type 3 genetics, Urinary Bladder Neoplasms mortality, Urinary Bladder Neoplasms pathology, Carcinoma, Transitional Cell metabolism, Receptor, Fibroblast Growth Factor, Type 3 metabolism, Urinary Bladder Neoplasms metabolism
Abstract: While fibroblast growth factor receptor 3 (FGFR3) is frequently mutated or overexpressed in nonmuscle-invasive urothelial carcinoma (UC), the prevalence of FGFR3 protein expression and mutation remains unknown in muscle-invasive disease. FGFR3 protein and mRNA expression, mutational status, and copy number variation were retrospectively analyzed in 231 patients with formalin-fixed paraffin-embedded primary UCs, 33 metastases, and 14 paired primary and metastatic tumors using the following methods: immunohistochemistry, NanoString nCounterTM, OncoMap or Affymetrix OncoScanTM array, and Gain and Loss of Analysis of DNA and Genomic Identification of Significant Targets in Cancer software. FGFR3 immunohistochemistry staining was present in 29% of primary UCs and 49% of metastases and did not impact overall survival (P = 0.89, primary tumors; P = 0.78, metastases). FGFR3 mutations were observed in 2% of primary tumors and 9% of metastases. Mutant tumors expressed higher levels of FGFR3 mRNA than wild-type tumors (P < 0.001). FGFR3 copy number gain and loss were rare events in primary and metastatic tumors (0.8% each; 3.0% and 12.3%, respectively). FGFR3 immunohistochemistry staining is present in one third of primary muscle-invasive UCs and half of metastases, while FGFR3 mutations and copy number changes are relatively uncommon., (© 2014 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.)
Published: 2014
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34. Integrative analysis of 1q23.3 copy-number gain in metastatic urothelial carcinoma.

Author: Riester M, Werner L, Bellmunt J, Selvarajah S, Guancial EA, Weir BA, Stack EC, Park RS, O'Brien R, Schutz FA, Choueiri TK, Signoretti S, Lloreta J, Marchionni L, Gallardo E, Rojo F, Garcia DI, Chekaluk Y, Kwiatkowski DJ, Bochner BH, Hahn WC, Ligon AH, Barletta JA, Loda M, Berman DM, Kantoff PW, Michor F, and Rosenberg JE
Subjects: Adult, Aged, Chromosomes, Human, Pair 1 genetics, Disease-Free Survival, Female, Humans, Male, Proportional Hazards Models, Prospective Studies, Urinary Bladder Neoplasms pathology, Urologic Neoplasms pathology, DNA Copy Number Variations genetics, Prognosis, Urinary Bladder Neoplasms genetics, Urologic Neoplasms genetics
Abstract: Purpose: Metastatic urothelial carcinoma of the bladder is associated with multiple somatic copy-number alterations (SCNAs). We evaluated SCNAs to identify predictors of poor survival in patients with metastatic urothelial carcinoma treated with platinum-based chemotherapy., Experimental Design: We obtained overall survival (OS) and array DNA copy-number data from patients with metastatic urothelial carcinoma in two cohorts. Associations between recurrent SCNAs and OS were determined by a Cox proportional hazard model adjusting for performance status and visceral disease. mRNA expression was evaluated for potential candidate genes by NanoString nCounter to identify transcripts from the region that are associated with copy-number gain. In addition, expression data from an independent cohort were used to identify candidate genes., Results: Multiple areas of recurrent significant gains and losses were identified. Gain of 1q23.3 was independently associated with a shortened OS in both cohorts [adjusted HR, 2.96; 95% confidence interval (CI), 1.35-6.48; P = 0.01 and adjusted HR, 5.03; 95% CI, 1.43-17.73; P < 0.001]. The F11R, PFDN2, PPOX, USP21, and DEDD genes, all located on 1q23.3, were closely associated with poor outcome., Conclusions: 1q23.3 copy-number gain displayed association with poor survival in two cohorts of metastatic urothelial carcinoma. The identification of the target of this copy-number gain is ongoing, and exploration of this finding in other disease states may be useful for the early identification of patients with poor-risk urothelial carcinoma. Prospective validation of the survival association is necessary to demonstrate clinical relevance., (©2014 AACR.)
Published: 2014
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35. Uncertainty in biogenic isoprene emissions and its impacts on tropospheric chemistry in East Asia.

Author: Han KM, Park RS, Kim HK, Woo JH, Kim J, and Song CH
Abstract: In this study, the accuracy of biogenic isoprene emission fluxes over East Asia during two summer months (July and August) was examined by comparing two tropospheric HCHO columns (ΩHCHO) obtained from the SCIAMACHY sensor and the Community Multi-scale Air Quality (CMAQ v4.7.1) model simulations, using three available biogenic isoprene emission inventories over East Asia: i) GEIA, ii) MEGAN and iii) MOHYCAN. From this comparative analysis, the tropospheric HCHO columns from the CMAQ model simulations, using the MEGAN and MOHYCAN emission inventories (Ω(CMAQ, MEGAN) and Ω(CMAQ, MOHYCAN)), were found to agree well with the tropospheric HCHO columns from the SCIAMACHY observations (Ω(SCIA)). Secondly, the propagation of such uncertainties in the biogenic isoprene emission fluxes to the levels of atmospheric oxidants (e.g., OH and HO2) and other atmospheric gaseous/particulate species over East Asia during the two summer months was also investigated. As the biogenic isoprene emission fluxes decreased from the GEIA to the MEGAN emission inventories, the levels of OH radicals increased by factors of 1.39 and 1.75 over Central East China (CEC) and South China, respectively. Such increases in the OH radical mixing ratios subsequently influence the partitioning of HO(y) species. For example, the HO2/OH ratios from the CMAQ model simulations with GEIA isoprene emissions were 2.7 times larger than those from the CMAQ model simulations based on MEGAN isoprene emissions. The large HO2/OH ratios from the CMAQ model simulations with the GEIA biogenic emission were possibly due to the overestimation of GEIA biogenic isoprene emissions over East Asia. It was also shown that such large changes in HO(x) radicals created large differences on other tropospheric compounds (e.g., NO(y) chemistry) over East Asia during the summer months., (Copyright © 2013 The Authors. Published by Elsevier B.V. All rights reserved.)
Published: 2013
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36. Gravity field of the Moon from the Gravity Recovery and Interior Laboratory (GRAIL) mission.

Author: Zuber MT, Smith DE, Watkins MM, Asmar SW, Konopliv AS, Lemoine FG, Melosh HJ, Neumann GA, Phillips RJ, Solomon SC, Wieczorek MA, Williams JG, Goossens SJ, Kruizinga G, Mazarico E, Park RS, and Yuan DN
Abstract: Spacecraft-to-spacecraft tracking observations from the Gravity Recovery and Interior Laboratory (GRAIL) have been used to construct a gravitational field of the Moon to spherical harmonic degree and order 420. The GRAIL field reveals features not previously resolved, including tectonic structures, volcanic landforms, basin rings, crater central peaks, and numerous simple craters. From degrees 80 through 300, over 98% of the gravitational signature is associated with topography, a result that reflects the preservation of crater relief in highly fractured crust. The remaining 2% represents fine details of subsurface structure not previously resolved. GRAIL elucidates the role of impact bombardment in homogenizing the distribution of shallow density anomalies on terrestrial planetary bodies.
Published: 2013
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37. Dawn at Vesta: testing the protoplanetary paradigm.

Author: Russell CT, Raymond CA, Coradini A, McSween HY, Zuber MT, Nathues A, De Sanctis MC, Jaumann R, Konopliv AS, Preusker F, Asmar SW, Park RS, Gaskell R, Keller HU, Mottola S, Roatsch T, Scully JE, Smith DE, Tricarico P, Toplis MJ, Christensen UR, Feldman WC, Lawrence DJ, McCoy TJ, Prettyman TH, Reedy RC, Sykes ME, and Titus TN
Abstract: The Dawn spacecraft targeted 4 Vesta, believed to be a remnant intact protoplanet from the earliest epoch of solar system formation, based on analyses of howardite-eucrite-diogenite (HED) meteorites that indicate a differentiated parent body. Dawn observations reveal a giant basin at Vesta's south pole, whose excavation was sufficient to produce Vesta-family asteroids (Vestoids) and HED meteorites. The spatially resolved mineralogy of the surface reflects the composition of the HED meteorites, confirming the formation of Vesta's crust by melting of a chondritic parent body. Vesta's mass, volume, and gravitational field are consistent with a core having an average radius of 107 to 113 kilometers, indicating sufficient internal melting to segregate iron. Dawn's results confirm predictions that Vesta differentiated and support its identification as the parent body of the HEDs.
Published: 2012
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38. Corrosion behavior and cytotoxicity of Mg-35Zn-3Ca alloy for surface modified biodegradable implant material.

Author: Park RS, Kim YK, Lee SJ, Jang YS, Park IS, Yun YH, Bae TS, and Lee MH
Subjects: 3T3 Cells, Absorption, Animals, Biocompatible Materials chemistry, Blood Vessels metabolism, Corrosion, Male, Materials Testing, Metals chemistry, Mice, Oxygen chemistry, Rats, Rats, Sprague-Dawley, Surface Properties, Absorbable Implants, Alloys chemistry, Calcium chemistry, Magnesium chemistry, Zinc chemistry
Abstract: This study was conducted to investigate the biocompatibility of Mg-Zn-Ca ternary alloy as a biodegradable material. The casting alloy underwent anodization in an alkaline electrolyte at current density 300 mA/cm(2) and frequency 50 Hz to obtain porous oxide layer. Plasma anodization film using pulse was shown to form irregular porous oxide film. As a result of corrosion test, the corrosion current was shown to decrease and the corrosion voltage was shown to increase in the anodized group, which showed the improvement of corrosion resistance after surface treatment. Sodium silicate (0.1 M) was directly oxidized due to high charges caused by spark and then formed SiO(2), and the compounds produced inside the film were shown MgO, Mg(2) SiO(4), and SiO(2.) In the histological examination in rats, all samples of the untreated group were shown to be absorbed 3 weeks later into the body. After the magnesium alloy was implanted, blood vessel expansion and tissue change were shown in the adjacent tissues. However, the changed tissues were shown to return to normal muscle tissues 4 weeks later when the alloy was completely absorbed. These results suggest that anodized Mg-35Zn-3Ca alloy has good biocompatibility in vivo and controls the absorption rate of biomaterials., (Copyright © 2012 Wiley Periodicals, Inc.)
Published: 2012
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39. Evaluation of characteristics on titanium surface treatment for absorption of functional groups.

Author: Jin GC, Park RS, Park HH, Seo JM, Lee SJ, and Lee MH
Subjects: Prostheses and Implants, Surface Properties, Biocompatible Materials chemistry, Titanium chemistry
Abstract: Background: In order to bind or fix bioactive materials directly to the surface of a Ti implant, the prior binding process of functional groups (FGs, -COOH and -OH) to the implant surface is necessary. Conventional binding processes are so high-cost and complex, so it is essential to find a simple and effective procedure for Ti-FG binding., Methods: Various electrolyte compositions and electrochemical processing were adopted in this study to develop a relatively simple and effective Ti-FG binding process. The ability of Ti-FG binding and calcium (Ca)/phosphorous (P) absorption and corrosion resistance were evaluated according to various titanium surface treatment in electrolyte involving -COOH and -OH ion by using X ray photoelectron spectroscopy (XPS), field emission scanning electron microscope (FE-SEM) and potentiodynamic scan method respectively., Results: In cases of -COOH, the anodic oxidation process (AN) showed an effective binding ability between -COOH and Ti surface. On the other hand, in cases of -OH, there were no significant differences in the result between the conditions used. In regard to the absorption of Ca and P on Ti surface, there was a minimal amount of Ca absorbed but no P was absorbed. The anodic oxidation series showed homogenous corrosion, whereas the electrolyte immersion (EL) series showed unstable corrosion. Although EL-OH showed a novel corrosion potential, the EL-COOH series showed good corrosion resistance over the anodic potential range., Conclusions: The ability of binding between FG and the Ti surface and Ca/P absorption were strongly associated with the surface potential (ζ potential), which was dependent on the pH of the electrolyte. Accordingly, in order to achieve the effective absorption of various FGs on the Ti surface, it is needed to develop the combination process in addition to the electric affinity, relation with the ζ potential.
Published: 2010

40. Prediction of wheat chemical and physical characteristics and nutritive value by near-infrared reflectance spectroscopy.

Author: Owens B, McCann ME, McCracken KJ, and Park RS
Subjects: Animal Nutritional Physiological Phenomena, Animals, Body Weight, Eating, Feces chemistry, Male, Nutritive Value, Random Allocation, Animal Feed analysis, Chickens growth & development, Spectroscopy, Near-Infrared veterinary, Triticum chemistry
Abstract: 1. The aims of this study were to investigate the potential of near infrared reflectance spectroscopy (NIRS) to predict the chemical and physical characteristics of wheat and also to predict the nutritive value of wheat for broiler chickens. 2. A total of 164 wheat samples, collected from a wide range of different sources (England, Northern Ireland and Canada), varieties and years, were used in this study. 3. Chemical and physical parameters measured included specific weight, thousand grain weight, in vitro viscosity, gross energy, nitrogen, neutral detergent fibre (NDF), starch, total and soluble non-starch polysaccharides (NSP), lysine, threonine, amylose, hardness, rate of starch digestion and protein profiles. 4. A total of 94 wheat samples were selected for inclusion in three bird trials and included at 650 g/kg in a typical UK starter/grower diet. Birds were housed in individual wire metabolism cages from 7 to 28 d and offered water and food ad libitum. Dry matter intake (DMI), live weight gain (LWG) and gain:feed ratio were measured weekly. A balance collection was carried out from d 14 to 21 for determination of apparent metabolisable energy (AME), ME:gain and dry matter retention. At 28 d the birds were humanely killed, the contents of the jejunum removed for determination of in vivo viscosity and the contents of the ileum removed for determination of ileal dry matter, starch and protein digestibility. 5. The wheat samples were scanned as whole and milled wheat, both dried and undried and NIRS calibrations, first excluding and then including the Canadian wheat samples, were developed. 6. NIRS calibrations for milled wheat samples may be useful for determining specific weight (R(cv)(2) = 0.75, for milled wheat dried), nitrogen (R(cv)(2) = 0.983 for milled and dried) and rate of starch digestion (R(cv)(2) = 0.791 for milled, dried and undried). 7. NIRS calibrations for whole wheat samples (undried) may be useful for determining wheat nutritive value, with good predictions for live weight gain (R(cv)(2) = 0.817) and feed conversion efficiency (R(cv)(2) = 0.825). 8. Inclusion of the Canadian wheat samples in the NIRS analysis provided additional robust calibrations for gross energy (R(cv)(2) = 0.86, dried and milled) and starch content (R(cv)(2) = 0.79, undried and milled). 9. This study shows that NIR is a useful tool in the accurate and rapid determination of wheat chemical parameters and nutritive value and could be extremely beneficial to both the poultry and wheat industry. 10. Further extension of the dataset would be recommended to further validate these findings.
Published: 2009
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41. Does lack of social support lead to more ED visits for older adults?

Author: Hastings SN, George LK, Fillenbaum GG, Park RS, Burchett BM, and Schmader KE
Subjects: Aged, Aged, 80 and over, Female, Humans, Male, North Carolina, Outpatients, Prospective Studies, Social Isolation, Emergency Service, Hospital statistics & numerical data, Social Support
Abstract: Objective: The goals of this study were to (1) determine whether level of social support and living situation predicted emergency department (ED) use among older adults and (2) identify correlates of ED visits according to whether the patient was admitted to the hospital., Methods: Secondary analysis of a longitudinal, prospective study was conducted., Results: In adjusted analyses, subjects who lived alone were 60% more likely to visit the ED than those who lived solely with their spouse. Neither type nor level of social support as measured by the Duke Social Support Index predicted ED use. Indicators of poor physical health (prior hospitalization, poorer self-rated health, and functional disability) were predictors of ED visits that resulted in hospitalization; however, these were not significantly associated with outpatient ED visits., Discussion: Older adults who live alone are more likely to visit the ED. Additional study is needed to understand the determinants of outpatient ED visits.
Published: 2008
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42. Relationship of rotation timing to pattern of clerkship performance in psychiatry.

Author: Park RS, Chibnall JT, and Morrow A
Subjects: Cluster Analysis, Humans, Clinical Clerkship, Clinical Competence, Internship and Residency statistics & numerical data, Psychiatry education, Psychiatry statistics & numerical data
Abstract: Objective: The authors investigated the association between psychiatry clerkship timing and pattern of student performance. Student rotation timing preference and specialty choice were explored as potential moderators., Methods: Archival data from six classes of third-year medical students were analyzed. Performance indicators included the National Board of Medical Examiners (NBME) psychiatry subject examination, Objective Structured Clinical Examination (OSCE), and attending evaluation. Cluster analysis grouped students into homogeneous subsets based on performance. Cluster membership was examined as a function of timing, with and without timing preference and specialty choice as covariates., Results: The association between performance, as indicated by cluster membership, and rotation timing was not significant. There were no significant relationships between performance trends and student preference for rotation order or specialty choice., Conclusion: The clerkship timing effect was not apparent for the psychiatry clerkship when the full pattern of student performance was examined. Student preference and specialty choice did not moderate performance.
Published: 2005
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43. Propofol for deep procedural sedation in the ED.

Author: Frazee BW, Park RS, Lowery D, and Baire M
Subjects: Adolescent, Adult, Analgesics, Opioid administration & dosage, Apnea chemically induced, Conscious Sedation adverse effects, Dose-Response Relationship, Drug, Drug Combinations, Female, Fentanyl administration & dosage, Fentanyl adverse effects, Humans, Hypnotics and Sedatives adverse effects, Hypotension chemically induced, Hypoxia chemically induced, Infusions, Intravenous, Male, Middle Aged, Patient Satisfaction, Propofol adverse effects, Prospective Studies, Conscious Sedation methods, Emergency Medical Services methods, Hypnotics and Sedatives administration & dosage, Propofol administration & dosage
Abstract: Unlabelled: We sought to evaluate the use of propofol (2,6-diisopropylphenol) for ED procedural sedation, particularly when administered in a routine fashion for a variety of indications., Methods: This was a prospective observational study conducted in an urban teaching ED. Propofol was administered by handheld syringe and combined with fentanyl. Measurements included propofol and fentanyl dose, serial vital signs, pulse oximetry, adverse events, and patient and physician satisfaction., Results: One hundred thirty-six subjects (18 to 69 years) were enrolled. Procedures included 82 (60.3%) abscess incision and drainages and 47 (34.6%) orthopedic reductions. Adverse events occurred in 14 cases (10.3%; 95% confidence interval 5.2% to 15.4%), including hypotension in 5, hypoxemia in 7, and apnea in 5. One patient required intubation. Both patient and physician satisfaction were excellent., Conclusions: ED procedural sedation with propofol was effective and well accepted by patients and physicians. However, it produced a significant incidence of hypotension, hypoxemia, and apnea.
Published: 2005
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44. The influence of testing context and clinical rotation order on students' OSCE performance.

Author: Blaskiewicz RJ, Park RS, Chibnall JT, and Powell JK
Subjects: Adult, Chi-Square Distribution, Education, Medical, Undergraduate trends, Evaluation Studies as Topic, Female, Gynecology education, Humans, Male, Obstetrics education, Probability, Psychiatry education, Students, Medical, Task Performance and Analysis, Clinical Competence, Curriculum, Education, Medical, Undergraduate standards, Educational Measurement
Abstract: Purpose: To investigate the influence of testing context and rotation order on third-year medical student performance on a common objective structured clinical examination (OSCE) station in both obstetrics-gynecology (ob-gyn) and psychiatry rotations., Method: Archival OSCE performance data (in the form of a 25-item binary content checklist) from one class of third-year medical students (n = 141) at Saint Louis University (2002-03) were aggregated and analyzed., Results: Despite the fact that the station was identical in both OSCEs, students were, in general, less likely to inquire about ob-gyn issues on the psychiatry OSCE and less likely to inquire about psychiatric issues on the ob-gyn OSCE, regardless of order of rotation. Order did have a positive effect on some results, such that students were more likely to mention menopause and vaginal dryness on the psychiatry OSCE if they had already had the ob-gyn rotation., Conclusion: The testing context may influence student approaches to patients in ways that bias their collection and interpretation of information. OSCE evaluations may better approximate true clinical context and complexity by presenting case scenarios that reflect a broader range of diagnostic possibilities than those limited to the recently completed rotation.
Published: 2004
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45. Construct validity of an objective structured clinical examination (OSCE) in psychiatry: associations with the clinical skills examination and other indicators.

Author: Park RS, Chibnall JT, Blaskiewicz RJ, Furman GE, Powell JK, and Mohr CJ
Subjects: Adult, Female, Gynecology education, Humans, Male, Obstetrics education, Regression Analysis, Reproducibility of Results, Specialty Boards statistics & numerical data, Clinical Competence statistics & numerical data, Education, Medical, Continuing, Educational Measurement statistics & numerical data, Psychiatry education
Abstract: Objective: The construct validity of checklist and global process scores for an objective structured clinical examination (OSCE) in psychiatry was assessed. Multiple regression analysis was used to predict psychiatry OSCE scores from the clinical skills examination, an obstetrics/gynecology (OB/GYN) OSCE, and the National Board of Medical Examiners (NBME) psychiatry subject examination., Methods: Archival data from two successive classes of third-year medical students (1999-2000, N=142; 2000-2001, N=144) were aggregated and analyzed., Results: The pattern and magnitude of convergence and discrimination were indicative of adequate construct validity for both the psychiatry checklist scores and the global process score. Clinical skills examination scores for history taking, interpersonal skills, and physical examination were related to psychiatry OSCE scores that reflected the same skill set. Construct validity was fairly higher for the global process rating., Conclusion: Evidence of construct validity of a psychiatry OSCE was obtained from multiple measures of performance, including the clinical skills examination. Findings lend support to the continued use of checklist and global process evaluations as part of OSCEs in psychiatry.
Published: 2004
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46. Evolution of emergency ultrasound.

Author: Price DD, Simon BC, and Park RS
Published: 2003

47. Displaced intra-articular calcaneal fracture treated surgically with limited posterior incision.

Author: Park IH, Song KW, Shin SI, Lee JY, Kim TG, and Park RS
Subjects: Adolescent, Adult, Aged, Calcaneus injuries, Evaluation Studies as Topic, Female, Follow-Up Studies, Fracture Fixation, Internal instrumentation, Fracture Healing physiology, Fractures, Bone diagnostic imaging, Humans, Injury Severity Score, Joint Dislocations diagnostic imaging, Male, Middle Aged, Radiography, Range of Motion, Articular, Retrospective Studies, Subtalar Joint injuries, Calcaneus surgery, Fracture Fixation, Internal methods, Fractures, Bone surgery, Joint Dislocations surgery, Subtalar Joint surgery
Abstract: The incidence of calcaneal fracture has been slowly increasing; however, the ideal treatment for displaced intra-articular fracture is not available yet, even though the fracture brings frequent complication and disability. Between April 1991 and March 1998, we treated 103 displaced intra-articular calcaneal fractures of 92 patients surgically with limited posterior incision, modified Gallie approach. There were thirty-seven tongue-type fractures, fifteen tongue-type fractures with moderate comminution, nineteen joint-depression fractures, twenty-nine joint-depression fractures with moderate comminution, and three extensively comminuted fractures. The fracture fragments were fixed mainly with partly threaded small cancellous screws or Steinmann pins without any bone graft. Ankle and subtalar motion was permitted immediately if fixation were stable enough. Otherwise, a short period of cast immobilization was utilized. With a mean follow-up of 28 months (range, 12 to 66 months), eighty six percent of feet had no pain or only occasional pain not requiring medication. Using American Orthopedic Foot and Ankle Society hindfoot score system for assessment, ninety percent of feet rated as good to excellent. We used "Circle draw test" for evaluation of subtalar motion during follow-up visitation and found eight-seven percent of feet showed good to excellent correlation with the functional recovery. We recommend a limited posterior incision for reduction and internal fixation of displaced intra-articular calcaneal fractures. For displaced intra-articular fractures with three or four large fragments without further comminution and without a displaced fracture of the calcaneal cuboid joint, this method is particularly useful. We also recommend a Circle draw test for evaluation of subtalar joint motion as well as an indicator of functional recovery after displaced calcaneal fractures.
Published: 2000
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48. Evaluation of a saliva alcohol test stick as a therapeutic adjunct in an alcoholism treatment program.

Author: Pate LA, Hamilton JD 2nd, Park RS, and Strobel RM
Subjects: Adult, Alcoholism diagnosis, Emergency Medical Services, Ethanol analysis, Ethanol blood, Ethanol urine, Humans, Male, Psychiatric Status Rating Scales, Rehabilitation Centers, Substance-Related Disorders diagnosis, Alcoholism rehabilitation, Saliva chemistry
Abstract: This study was designed to evaluate the clinical usefulness of a saliva alcohol dipstick by comparing dipstick saliva alcohol concentrations to simultaneous blood and urine alcohol concentrations. The sample consisted of 211 saliva tests and blood alcohol concentrations and 189 urine alcohol concentrations. The dipsticks had a specificity of 0.965, a sensitivity of 0.895, a positive predictive value of 0.850, a negative predictive value of 0.977 and a Pearson's product moment correlation coefficient of 0.609 for blood alcohol concentrations and salivary alcohol concentrations, suggesting that the saliva dipstick is useful as a qualitative test in certain settings but is less useful than previously reported as a semiquantitative test.
Published: 1993
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49. Incorporation of different types of n-3 fatty acids into tissue lipids of poultry.

Author: Chanmugam P, Boudreau M, Boutte T, Park RS, Hebert J, Berrio L, and Hwang DH
Subjects: Animals, Corn Oil administration & dosage, Fatty Acids, Omega-3 analysis, Female, Fish Oils administration & dosage, Linseed Oil administration & dosage, Lipids chemistry, Male, Muscles chemistry, Muscles metabolism, Skin chemistry, Skin metabolism, Thigh, Animal Feed, Chickens metabolism, Dietary Fats, Unsaturated administration & dosage, Fatty Acids, Omega-3 pharmacokinetics, Lipid Metabolism
Abstract: The objective of the present study was to compare the incorporation of different types of n-3 polyunsaturated fatty acids into thigh muscle lipids of poultry. Nine groups of broiler chicks were fed diets supplemented with three levels (1.0, 2.5, and 5.0%) of either corn, linseed, or menhaden oil. Birds supplemented with linseed oil, rich in linolenic acid (C18:3n-3), had significantly higher levels of n-3 fatty acids and higher n-3:n-6 ratios than those supplemented with the same level of menhaden oil, primarily due to an accumulation of C18:3n-3. Levels of eicosapentaenoic acid (C20:5n-3) were increased (P less than .05), compared with the controls fed the same level of corn oil, in the groups fed the two higher levels of linseed oil, and in all the groups fed menhaden oil. Linolenic acid is less susceptible to auto-oxidation, and is less likely to impart an off-flavor to the muscle. Thus, if it is desirable to increase the n-3:n-6 ratio in poultry, seed meals or oils with a high content of C18:3n-3 could be used in poultry feeds.
Published: 1992
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50. Perinuclear microtubules in postnatal rat heart.

Author: Park RS, Légier MF, Cartwright J Jr, and Goldstein MA
Subjects: Animals, Male, Rats, Inbred Strains, Statistics as Topic, Animals, Newborn anatomy & histology, Microtubules ultrastructure, Papillary Muscles ultrastructure, Rats anatomy & histology
Abstract: Cytoplasmic microtubules can be divided into two subpopulations: 1) those adjacent to the nucleus (perinuclear), and 2) those distributed between the myofilament bundles (nonperinuclear). Previous observations (Cartwright and Goldstein, '83) indicate total cytoplasmic microtubule numeric density increases to a maximum at 5-9 days and decreases to the steady value of the adult muscle. We have examined the numeric density (mean numbers of microtubule profiles per micron2 cross-sectional area) of the perinuclear subpopulation and compared it to the numeric density of the total cytoplasmic microtubule population in postnatally developing rat papillary muscle ages 1, 3, 5, 9, 21, and 42 days, and adult. The perinuclear region was defined as the area around the nucleus which extends to the 0.273 micron from the nuclear envelope. The density of perinuclear microtubules did not change with postnatal development. Our study suggests that perinuclear microtubules are a separate and relatively stable subpopulation of the total population of cytoplasmic microtubules and may serve a function different from that of the more variable nonperinuclear microtubules.
Published: 1984
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