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At the present stage of social development, which is forming a new high-tech world system with all its challenges and problems, it is necessary to provide all participants in social and economic relations with a single and convenient environment for interaction, to improve the level and quality of life, and to ensure sustainable development. «Smart city» technologies, and their further extrapolation to the scale of a regional entity – a «smart region» – make it possible to ensure sustainable development for all residents of the region and consumers of municipal and regional services – citizens, public and business organizations, as well as government. Due to the constant development of the transport industry and new opportunities for the transportation of passengers and goods, it is interesting to study the transport and logistics segment of the «smart region». It explains the relevance and practical significance of this study, which presents a theoretical and methodological substantiation of the formation of a «smart» transport and logistics complex with its positioning as a factor of sustainable development of the region, on the example of the Volgograd region. This approach is original, has a high degree of reliability, the ability to build and verify the forecast of the socio-economic development of the region. The developed model in the study represents the authors' vision of the development of the transport and logistics complex of the Volgograd region in the future, defines short, medium and long-term priorities, goals and objectives, proposes the main directions of development, mechanisms for achieving the set goals and objectives, taking into account the achieved level and identified problems. The results of approbation prove the expediency of its use in the development and scientific substantiation of the strategy of socio-economic development at the regional level.

A parallel reductive amination of heteroaromatic amines has been performed using a combination of ZnCl2-TMSOAc (activating agents) and NaBH(OAc)3 (reducing agent). A library of diverse secondary amines was easily prepared on a 50-300 mg scale.

One-pot variation of Castagnoli condensation, that is, reaction of cyclic anhydrides, amines, and aldehydes, has been developed as a combinatorial approach to 1,2-disubstituted 5-oxopyrrolidine- and 6-oxopiperidine-3-carboxylic acids, as well as their benzo-analogues. Utility of the method to multigram preparation of building blocks and synthetic intermediates was also demonstrated. The final products are obtained in high yields and diastereoselectivity. The method fits well in the concept of lead-oriented synthesis; in particular, it can be used for the design of lead-like compound libraries, even if the strictest cut-offs are applied to the physicochemical properties of their members.

A convenient procedure for the parallel synthesis of 3-hydroxy-1,5-dihydro-2H-pyrrol-2-ones through a three-component condensation of active methylene compounds, aldehydes, and amines was developed. It was shown that the use of acetic acid as the reaction medium was suitable for the considerably reactive substrates with no additional functionalities. The substrates with low reactivity and those possessing carboxylic groups or additional basic centers required the use of DMF as the solvent and chlorotrimethylsilane as the reaction promoter was necessary. More than 3000 pyrrolones were synthesized by the developed procedure. To demonstrate the scope of the described approach 114 library representatives were fully characterized.

128 Azomethines were synthesized through condensation of carbonyl compounds with various amines in pyridine in the presence of Me(3)SiCl as promoter and water scavenger in 58-98 % yield. Et(3)N was added to reaction mixtures before precipitating the product with H(2)O to prevent acid catalyzed hydrolysis of the C=N bond. The scope and limitation of the method are discussed. High yields and simple setup/workup procedure make this method suitable for the combinatorial synthesis of azomethines, which are suitable as starting materials for high throughput synthesis of various combinatorial libraries. The azomethines synthesized were used as starting materials in a one-pot combinatorial synthesis of amines and amides.

Rhodium and iridium complexes of a new ferrocene-derived bis(N-heterocyclic carbene) ligand, [M(cod){1,2-(MeNCHCHNCCH(2))(2)C(5)H(3)}Fe(C(5)H(5))]BF(4) (M = Rh, 8a; M = Ir, 8b; cod = 1,5-cyclooctadiene), were synthesized from the corresponding bis(imidazolium) salt 6. The molecular structure of 8a was determined by single-crystal X-ray diffraction. Complexes 8a and 8b smoothly react with CO with displacement of the chelating cod ligand to give the corresponding dicarbonyl derivatives 9a and 9b.