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A one-pot parallel reductive amination of aldehydes with heteroaromatic amines.
- Source :
-
ACS combinatorial science [ACS Comb Sci] 2014 Aug 11; Vol. 16 (8), pp. 375-80. Date of Electronic Publication: 2014 Jul 10. - Publication Year :
- 2014
-
Abstract
- A parallel reductive amination of heteroaromatic amines has been performed using a combination of ZnCl2-TMSOAc (activating agents) and NaBH(OAc)3 (reducing agent). A library of diverse secondary amines was easily prepared on a 50-300 mg scale.
- Subjects :
- Aldehydes chemical synthesis
Amination
Amines chemistry
Chlorides chemistry
Combinatorial Chemistry Techniques
Hydrocarbons, Aromatic chemistry
Oxidation-Reduction
Reducing Agents chemistry
Small Molecule Libraries chemistry
Zinc Compounds chemistry
Aldehydes chemistry
Amines chemical synthesis
Hydrocarbons, Aromatic chemical synthesis
Small Molecule Libraries chemical synthesis
Subjects
Details
- Language :
- English
- ISSN :
- 2156-8944
- Volume :
- 16
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- ACS combinatorial science
- Publication Type :
- Academic Journal
- Accession number :
- 24956115
- Full Text :
- https://doi.org/10.1021/co5000568