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1. A platinum(IV) complex oxidizes guanine to 8-oxo-guanine in DNA and RNA

Author

Choi, Sunhee, Delaney, Sarah, Orbai, Lucian, Padgett, Elizabeth J., and Hakemian, Amanda S.

Subjects
Chemistry, Inorganic -- Research, Platinum -- Physiological aspects, Oxidation-reduction reaction -- Physiological aspects, Guanine -- Physiological aspects, DNA damage -- Physiological aspects, RNA -- Physiological aspects, Phosphates -- Physiological aspects, Coordination compounds -- Physiological aspects, Chemistry
Abstract

Research has been conducted on the oxidative damage of DNA by metal complexes. Results indicate that a platinum complex with the high reduction potential oxidizes such compounds as guanine in guanosine-5'-monophosphate and a douple-stranded oligonucleotide to 8-oxo-guanine.

Published
2001

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