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Introduction/purpose: The development of elastomeric materials based on synthetic polyisoprene (IR) with high green strength is a rather urgent task, because it allows to replace, completely or partially, the main ingredient - natural rubber in responsible rubber products. The aim of the work was an additional increase in the green strength values of IR and rubber mixtures based on it by its modification with high-density polyethylene of PND 277-73. Methods: The main methods of the research of the technological, physicalmechanical and operational properties were used. All tests conformed to ASTM or ISO standards. Rubber compounds were made in the Haake PolyLab rubber mixer. In parallel with the effects of modification, the influence of the mixing temperature on the main properties of IR and NR based elastomeric materials was investigated. Results: It is shown that the increase in the mixing temperature of NR and IR for 20ºC leads to significant changes in the technological properties of rubber compounds (primarily green strength), as well as the physicalmechanical and operational properties of cured rubber. It has been established that a significant increase in the green strength of the rubber compound is achieved by combining IR with 7 mass. % HDPE. Conclusion: The developed polymer composition based on IR and HDPE has a level of green strength of the rubber compound 2 times higher than that of natural rubber, while maintaining the physical-mechanical and operational characteristics of cured rubbers at the level of natural rubber. The polymer composition IR/HDPE 93/7 can be recommended for use in the manufacture of products whose manufacturing technology requires increased green strength of rubber compounds, including largesized and all-metal tires.

The article is devoted to the problem of identifying the relationship between the subjective feeling of loneliness and the tendency to computer and gaming addiction in adolescence. Lonely people tend to be very unhappy, they have few social contacts, and their personal connections with other people are either limited or severed. In connection with the development of computer and gaming technologies, computer and gaming addiction is highly prevalent and tends to increase. Studying the relationship between the subjective feeling of loneliness and the tendency to computer gaming addiction in adolescence is a significant task in understanding the reasons for the formation of computer gaming addiction in adolescence and is associated with the possibility of timely correction of such deviations in the development and behavior of boys and girls. We assume that the subjective feeling of loneliness determines the development of computer and gaming addiction in adolescence. The article presents the results of a correlation analysis between the parameters of feelings of loneliness and computer game addiction: "severity of computer game addiction" and "general loneliness", "positive loneliness", "dependence of loneliness on communication". The results of the study allow us to conclude that an increase in indicators according to the criteria of "general loneliness" and "subjective feeling of loneliness" leads to an increase in the criterion of "severity of computer gaming addiction".

Abstract Background The Infants and Toddlers Dermatology Quality of Life (InToDermQoL) is the dermatology-specific proxy health-related quality of life (HRQoL) instrument for children from birth to 4 years. The aim of the present study was to confirm the responsiveness and establish minimal clinically important difference (MCID) for the InToDermQoL. Methods Parents of children with skin diseases were asked to fill in the InToDermQoL at the initial visit (T1) and subsequent consultation (T2). We hypothesized that correlations between change scores of the InToDermQoL and change scores of global assessment of clinical severity by dermatologists and by patients’ parents should be above 0.3. The receiver operating characteristic (ROC) curves method was also used for confirmation of responsiveness and determination of MCIDs of the InToDermQoL. The area under the ROC curve (AUC) was used as an indicator of responsiveness. Results Results of 442 patients were included. Correlations between change scores of age-specific versions of the InToDermQoL and change scores of global assessment of clinical severity by dermatologists and by patients’ parents were above 0.3 (0.46-0.74). AUCs for age-specific versions of the InToDermQoL were acceptable (above 0.7) or excellent (above 0.8). Estimated MCIDs for the InToDermQoL were as follows: 3 points of total score change for 0–11 months, 5 for 1–2 years and 3 or 4 for 3–4 years version. Estimated MCIDs for the InToDermQoL version for 1–2-year-old children was higher than MCIDs for the 3–4-year-old version despite the higher number of items in the latter. Therefore a MCID of 5 was recommended for both these versions. Conclusions Responsiveness for all age-specific versions of the InToDermQoL questionnaire was confirmed. MCIDs for the InToDermQoL are proposed as follows: 3-point change of the total score for age version 0–11 months and 5-point for the age versions 1–2 years and 3–4 years.

The purpose of this article is to review the current state of research in the field of thermal emission cooling and the feasibility study effect and to highlight their potential applications in astronautics and rocket science, especially for reusable spacecraft and high-speed aircraft. The article summarizes the results of the work of several research groups from several universities in Russia, the USA and China. It discusses theoretical models and experimental developments of thermal emission cooling technology, without going into detailed methodologies. The main research in this area is carried out by teams from the universities of Michigan, Colorado, Vermont and Texas in the USA with the active support of Lockheed Martin Corporation. Experimental studies of this technology are already being actively carried out at these universities. Moreover, the results already obtained correlate well with the results of theoretical study, from which we can conclude about the prospects of research. The effect of thermoelectronic emission makes it possible to reduce the temperature of the leading edges of the spacecraft, which is especially important for reusable spacecraft and unmanned missions, where maintaining the optimal temperature of components becomes a key factor in the service life and reliability of the system.

Background: The Infants and Toddlers Dermatology Quality of Life (InToDermQoL) questionnaire is the first dermatology-specific proxy health related QoL instrument for children from birth to 4 years. Score meaning bands and the sensitivity to successful therapeutic intervention are important to interpret the clinical meaning of an instrument. Objective: The aim of the present study was to check the sensitivity to successful therapeutic intervention and establish score bands of the InToDermQoL questionnaire. Methods: Parents or grandparents of 424 children with skin diseases from Spain, Malta, Croatia, Romania, Greece, and Ukraine filled in national language versions of the InToDermQoL questionnaire. Disease severity of children with atopic dermatitis was assessed by SCORAD (Scoring atopic dermatitis). Cohen’s d was used to assess the responsiveness of the instrument. Results: The mean total InToDermQoL scores significantly decreased after treatment. Severity grading of the SCORAD scores gave stratification of the InToDermQoL severity grades based on 95% confidence intervals. Scores below a calculated minimal important difference of 2 corresponded to no effect on patient’s health related QoL. Limitations: Score banding may be slightly different across patient population and study context. Conclusion: All 3 age-specific versions of the InToDermQoL questionnaire showed sensitivity to treatment. Score bands for the InToDermQoL questionnaire have been established.

The article is devoted to revealing the specifics of teaching reading for detailed comprehension in high school. Based on the analysis of methodological literature, the concept of “reading for detailed comprehension” is disclosed, and the psychological mechanisms that determine the effectiveness of this type of reading in a foreign language lesson in high school are characterized. The article describes the stages of work on reading for detailed comprehension. A list of formed speech skills and abilities in this kind of reading in a foreign language among high school students is presented based on the requirements of the Federal State Educational Standard, the Exemplary Work Program in English, and controlled content elements in the Universal Codifier in English. The authors of the article pay special attention to the exercises used in teaching reading for detailed comprehension, aimed at a deep understanding of a foreign language text presented in graphic form. On the example of working with a text on the topic “Art”, the types of exercises that allow a foreign language teacher to effectively form speech skills and abilities in reading for detailed comprehension at a foreign language lesson in high school are described.

Background: Asthma is a chronic inflammatory disorder of the airways and one of the most important non-communicable diseases worldwide. Analyzing crowdsourced data can help understand public interest and unmet needs as well as potential factors influencing search behavior. Objective: The study aimed to investigate asthma-related web search data in Europe to identify possible regional and seasonal variations and to assess public interest. Methods: Google Ads Keyword Planner was used to measure search volume for search terms related to asthma, allergic asthma, and bronchial asthma in 21 European countries between January 2018 and December 2021. The top 10 keywords of each country were categorized qualitatively. Search volume per 100 000 inhabitants was descriptively assessed in terms of regional and seasonal trends. Spearman correlations between search volume and pollen concentration as well as coronavirus disease (COVID-19) cases were investigated. Results: The median search volume per 100 000 inhabitants for asthma and allergic asthma was highest in Northern and Western Europe, while the highest search volume for bronchial asthma was observed in Western and Eastern regions. A seasonal trend was identified for all search terms and in all regions. Correlations were found between search frequency and pollen load and search behavior and COVID-19 cases. Overall, Europeans were most interested in the diseases in general, their treatment options, and symptoms. Conclusion: These results highlighted the need for reliable and region-specific information about the disease and for public campaigns to improve asthma control. The study also emphasizes the importance of using crowdsourced data for a more encompassing overview beyond conventional healthcare data.

The present study aimed to evaluate the effect of sodium-glucose co-transporter 2 (SGLT2) inhibitor dapagliflozin therapy on the prooxidant-antioxidant balance (PAB) in patients with diabetic kidney disease. Methods. A total of 88 patients with type 2 diabetes mellitus (DM) and diabetic nephropathy (DN) were included in this single-center randomized open-label prospective study. All patients were randomly divided into 2 groups: 45 patients received a standard course of treatment, which included antidiabetic drugs, renin-angiotensin-aldosterone system blockers, and HMG-CoA reductase inhibitors (statins). In addition to the standard therapy, the remaining 43 patients were prescribed the SGLT2 inhibitor dapagliflozin 10 mg per day. Patients were re-examined after 6 months of treatment. The blood PAB was calculated as the ratio of total hydroperoxides (THP) to total antioxidant activity (TAA). The level of THP and TAA was determined by the colorimetric method. Results. PAB was significantly elevated in type 2 DM patients with nephropathy due to TAA decrease and THP level increase when compared to the control group. The highest values of PAB were found in the late stages of DN in patients with glomerular filtration rates

Abstract is missing (Short communication)

Introduction. The purpose of the article is to consider the effect of damping in the shock absorber on smooth running, continuous rolling of the wheel and energy loss in the suspension of the car.Materials and methods. The review is based on the analysis of the amplitude-frequency characteristics of a two-mass car model and the dependence of the shock absorber operation during the oscillation cycle on the frequency of kinematic action.Results. The article presents a calculation scheme and equations of dynamics of a two-mass oscillatory system equivalent to an automobile suspension. The frequencies at which the amplitude-frequency characteristics intersect for different levels of damping (invariant points) in a two-mass oscillatory system are calculated. The relative operation of the shock absorber for the oscillation cycle concept is proposed and a formula for calculating the relative operation of the shock absorber in a two-mass oscillatory system is given. A comparative analysis of graphs characterizing smooth running, continuous rolling of the wheel and energy losses in the suspension is carried out.Discussion and conclusions. It is revealed that significant contradictions between these requirements arise only near the second resonance of the sprung mass, with an increase in the frequency of vibrations in the resonant zone, these contradictions are decrease.

The work deals with the design acceleration of optimal turbomachines. For its solution, it is proposed to apply mathematical optimization methods at the initial design stage. The goal of the study was to develop a one-step algorithm for optimal compressor wheel design. The application of the algorithm has a decisive advantage in comparison to the traditional iterative method for turbomachines design. The task of designing a turbomachine is multi-parameter and interdisciplinary and involves different requirements, which often contradict each other, consequently several optimality criteria can be used simultaneously. The traditional method consists in performing one-dimensional thermal and gasdynamic calculations with subsequent refinement using numerical study. Further fine-tuning of the wheel geometry includes variation of the blade angle at the exit from the impeller, as well as of the height of the flow path at the exit from the wheel. One-step global optimization was performed by using a particle swarm algorithm involving eleven variable parameters. The objective function is thermodynamic efficiency, calculated by stagnation parameters. The authors compare the results of calculating the geometry of the centrifugal compressor wheel by the traditional sequential method and by the newly developed global optimization method. The compressor wheel has an outer diameter of 200 mm, the diameter of the hub is 52 mm, the rotational speed is 60,000 rpm and the required compression ratio is 3.7. In the traditional optimization method, the blade angles and the profile thickness are varied in three or four blade cross sections. The novelty of the developed one-step algorithm consists in the optimization of the initially three-dimensional shape of the flow path. Testing has shown that the one-step global optimization method provides an efficiency gain of about 2 %. Compared to the traditional method, the required time decreased 6 to 18 times. The proposed method can be applied to the design of turbomachines of various dimensions. The developed algorithm can be used as a basis for external modules in various existing packages, such as Ansys, Comsol and SolidWorks.

The supersonic flow of a reactive gas mixture with Mach reflection of oblique shocks and pulsed energy supply at the Mach stem is considered within the framework of the Chapman–Jouguet theory. An approximate analytical model is proposed that quickly determines the shape and size of the shock-wave structure as well as the flow parameters in various flow regions. As an example of the application of the proposed analytical model, the “first barrel” of a highly overexpanded jet flow of an air-methane mixture with a high supersonic velocity, is studied. Flows of hydrogen–air and hydrogen–oxygen mixtures were also considered for comparison with preceding numerical results. The height of the triple point of the Mach reflection is determined in the presence of a change in the chemical composition of the mixture and an isobaric pulsed energy supply at the main shock.

Introduction. Endoscopic submucosal dissection (ESD) is a standard method of local excision of benign colon tumors. Nevertheless, it is not widely used because of its technical difficulty and risk of complication especially in right colon. The OBJECTIVE was to improve the results of treatment of patients with right colon neoplasms.Methods and materials. The results of 152 consecutive patients (median age 66 years, 88 female) with lateral spreading tumors (LST) were analyzed. Logistic regression was performed to evaluate risk factors of conversion and complications.Results. ESD as planned performed in 133 out of 152 patients. Conversion to bowel resection occurred in 19 cases. In the logistic regression model, lifting less than 3 mm (p=0.034) was independent risk factor of the conversion. Postoperative complications up to 30 days occurred in 5 out of 133 (3.8 %) of patients underwent ESD. There was no mortality after ESD. Severe fibrosis the base of the neoplasm was the only risk factor of postoperative complications (95 % CI=1.0—1.2; p=0.007). Final pathology revealed that 127 out of 133 patients (95.5 %) had adenomas and 6 out of 133 (4.5 %) patients had early adenocarcinomas. R0 resections was performed in 94/133 (70.7 %) cases.Conclusions. ESD is the safe and efficient method of local excision of benign right colon neoplasms. Unfavorable lifting (p=0.05) and submucosal fibrosis (p=0.007) are risk factors of ESD failure.

Background. One of the tasks of designing long-term electronic storage is to minimize the number of data carriers while achieving the maximum possible reliability of information storage. When using optical disks as media, this problem can be solved by combining the media into RAID structures. However, for archives that do not use expensive robotic libraries, there is a problem of rapid access to stored information. The problem can be solved by combining media in hybrid structures, where along with RAID arrays; information is also stored on single media. The aim of the study is to build a mathematical model of the reliability of information storage on optical disks combined in hybrid structures (named in the paper as G5, G6, G15, G16), and determine the most profitable structure using this model. Materials and methods. The model is based on well-known methods for evaluating the reliability of RAID arrays developed for hard disks, which were supplemented with expressions to account for the reliability of storing information on groups of single disks. The initial data for the model is considered: the total volume of archive storage, the capacity of a single optical disk, the probability of failure of the optical disk during storage between integrity checks, the conditional number of disks with information in the RAID array, and the number of spare copies being made. Results. A model is constructed and simulations are performed for various values of the capacity of the electronic archive. For comparison, we also performed simulations for RAID-based archives of the most common types (5, 6, 15, 16), as well as for an archive based on single disks with spare copies. It is confirmed that although hybrid structures are less reliable than "pure" RAID, they are significantly superior to archives on single disks. Conclusions. According to the results of the study, we can definitely recommend the G16 structure for creating archives on optical disks combined in hybrid structures.

Aim. To study the causes of falciparum malaria deaths in Russian Federation and to optimize therapy for severe forms of the disease. Materials and methods. The analysis of falciparum malaria cases with deaths recorded in Russian Federation from 2013 to 2017 was conducted. The results of optimization of pathogenetic therapy of severe forms of falciparum malaria for the prevention of adverse outcomes in the intensive care unit of the Infectious Clinical Hospital №2 of Moscow in 44 patients with severe course are presented. Treatment, clinical laboratory and instrumental investigations were carried out in accordance with our intensive care protocol, which took into account the current WHO recommendations. Results. From 2013 to 2017 there were nine deaths from falciparum malaria reported in patients from African countries (6) and India (3). In Russia, due to the lack of effective drugs of artemisinin group, quinine with tetracycline or doxycycline is used for etiotropic therapy of patients with complicated form of falciparum malaria. In the management of such patients, the basis for treatment was the prevention of ischemic, reperfusion injuries of organs and hemorrhagic complications. In the infectious clinical hospital №2 of Moscow, since 2007, the intensive care unit has developed and tested a protocol for intensive therapy in patients with severe and complicated forms of falciparum malaria, including preventive methods of extracorporeal hemocorrection with prolonged veno-venous hemodiafiltration therapy and plasmapheresis, as a result of which the mortality rate decreased from 84 to 6.8% Conclusion. The country's lack of anti-malarial drugs, the insufficient awareness of the population about the risk of infection and measures to prevent malaria, late referral of cases for medical care and errors of clinical diagnosis and treatment annually lead to fatal outcomes. In such situation, the experience of optimizing the treatment of severe falciparum malaria is particularly useful, allowing decreasing the mortality.

Aim of review. To generalize scientific data and to develop modern concept on the issue of diagnosis, staging and treatment of early rectal cancer. Summary. The world-wide issues of early rectal cancer are discussed in the review. Diagnostic methods and staging of the early cancer and premalignant states are discussed. Prospects of improvement of early rectal cancer treatment approach are outlined, advantages of the rectum-preserving techniques are justified. Conclusion. Early rectal cancer is rarely observed neoplasm that may be the main cause for diagnostic and staging difficulties. So far the choice of surgical method for early rectal cancer is a subject for discussion, at the same time the choice of method is determined not only by the tumor invasion depth, but also by the presence of risk factors for regional lymph node involvement.

One type of ectopic pregnancy is where the pregnancy is implanted in the scar left in the uterus following a cesarean section; these cases are thought to be one in 1800-3000 pregnancies. The increase in the incidence of cesarean scar pregnancy (CSP) is a consequence of the increasing rates of cesarean delivery. If misdiagnosed CSP can be a cause of life-threatening pregnancy complications. They include morbidly adherent placenta, placenta previa, and severe hemorrhage. If such a pregnancy is allowed to continue, a uterine scar rupture with hemorrhage will ensue and necessitate hysterectomy. It is therefore crucial to timely diagnose and manage these pregnancies. The therapeutic options can be medical, surgical, or a combination of both. However there has been no consensus on the management still yet. In this article, there is a systematic up-to-date review on CSP diagnosis, treatment and prevention measures.

Transanal endoscopic microsurgery (TEM) is the method used in cases of benign tumors at the early stages of rectal cancer. The tumor localization in peritonized part of the rectum indicates a limiting level for removal of the neoplasm. TEM was performed on 137 patients. The mean age was 63,8±9,8 years and the number of women consisted of 65,7%. Neoplasms were located in the upper ampullar rectum and a potential possibility of connection with the peritoneal cavity was noted in 12 (8,7%) patients, but during TEM it was only in 5 cases. There wasn’t any conversion to a peritoneal surgery. The wound closures were carried out from the side of the rectum lumen and all the operations were finished with the control laparoscopy and formation of sigmostoma. The stomas were closed in 3 patients on fifth- sixth weeks. A connection with the peritoneal cavity during TEM isn’t critical event in the case of wound closure through surgical rectoscope and it doesn’t lead to the conversion to radical operation.

We obtained a theoretical analysis of stationary Mach configurations of shock waves with a pulsed energy release at the main (normal) shock and a corresponding change in gas thermodynamic properties. As formation of the stationary Mach configuration corresponds to one of two basic, well-known criteria of regular/Mach shock reflection transition, we studied here how the possibility of pulsed energy release at the normal Mach stem shifts the von Neumann criterion, and how it correlates then with another transition criterion (the detachment one). The influence of a decrease in the “equilibrium” gas adiabatic index at the main shock on a shift of the solution domain was also investigated analytically and numerically. Using a standard detonation model for a normal shock in stationary Mach configuration, and ordinary Hugoniot relations for other oblique shocks, we estimated influence of pulsed energy release and real gas effects (expressed by decrease of gas adiabatic index) on shift of von Neumann criterion, and derived some analytical relations that describe those dependencies.

The purpose of this paper is an experimental investigation of the influence of properties of the silicon defect layer in a dielectric photonic crystal on the transmission peak spectral properties. The influence of the defect layer thickness on the defect mode frequency is shown. The possibility of changing characteristics of transmission peak by green laser illumination of the silicon layer is demonstrated and analyzed using a photonic crystal approach. It is experimentally found that illumination leads to a decrease of transmission coefficient value at the defect mode frequency, but does not lead to a change of this peak frequency. The non-equilibrium carriers concentration and their lifetime have been evaluated. The results of this paper can be used in manufacturing controllable circuits in millimeter waveband and the approach can be used in semiconductors manufacture as non-destructive control of semiconductors properties method.

In this study, we obtain the comparative analysis of methods of quick approximate analytical prediction of Mach shock height in planar steady supersonic flows (for example, in supersonic jet flow and in narrowing channel between two wedges), that are developed since the 1980s and being actively modernized now. A new analytical model based on flow averaging downstream curved Mach shock is proposed, which seems more accurate than preceding models, comparing with numerical and experimental data.

One of the modern trends in the design of human−machine interfaces (HMI) is to involve the so called spiking neuron networks (SNNs) in signal processing. The SNNs can be trained by simple and efficient biologically inspired algorithms. In particular, we have shown that sensory neurons in the input layer of SNNs can simultaneously encode the input signal based both on the spiking frequency rate and on varying the latency in generating spikes. In the case of such mixed temporal-rate coding, the SNN should implement learning working properly for both types of coding. Based on this, we investigate how a single neuron can be trained with pure rate and temporal patterns, and then build a universal SNN that is trained using mixed coding. In particular, we study Hebbian and competitive learning in SNN in the context of temporal and rate coding problems. We show that the use of Hebbian learning through pair-based and triplet-based spike timing-dependent plasticity (STDP) rule is accomplishable for temporal coding, but not for rate coding. Synaptic competition inducing depression of poorly used synapses is required to ensure a neural selectivity in the rate coding. This kind of competition can be implemented by the so-called forgetting function that is dependent on neuron activity. We show that coherent use of the triplet-based STDP and synaptic competition with the forgetting function is sufficient for the rate coding. Next, we propose a SNN capable of classifying electromyographical (EMG) patterns using an unsupervised learning procedure. The neuron competition achieved via lateral inhibition ensures the “winner takes all” principle among classifier neurons. The SNN also provides gradual output response dependent on muscular contraction strength. Furthermore, we modify the SNN to implement a supervised learning method based on stimulation of the target classifier neuron synchronously with the network input. In a problem of discrimination of three EMG patterns, the SNN with supervised learning shows median accuracy 99.5% that is close to the result demonstrated by multi-layer perceptron learned by back propagation of an error algorithm.

Chernyshov O. V. Комплексная психофармокотерапия дисморфных болевых ощущений у подростков с психическими расстройствами = Integrated psychopharmacotherapy dismorfing pain in adolescents with psychiatric disorders. Journal of Education, Health and Sport. 2015;5(8):210-218. ISSN 2391-8306. DOI 10.5281/zenodo.28073 http://dx.doi.org/10.5281/zenodo.28073 http://ojs.ukw.edu.pl/index.php/johs/article/view/2015%3B5%288%29%3A210-218 https://pbn.nauka.gov.pl/works/607755 Formerly Journal of Health Sciences. ISSN 1429-9623 / 2300-665X. Archives 2011–2014 http://journal.rsw.edu.pl/index.php/JHS/issue/archive Deklaracja. Specyfika i zawartość merytoryczna czasopisma nie ulega zmianie. Zgodnie z informacją MNiSW z dnia 2 czerwca 2014 r., że w roku 2014 nie będzie przeprowadzana ocena czasopism naukowych; czasopismo o zmienionym tytule otrzymuje tyle samo punktów co na wykazie czasopism naukowych z dnia 31 grudnia 2014 r. The journal has had 5 points in Ministry of Science and Higher Education of Poland parametric evaluation. Part B item 1089. (31.12.2014). © The Author (s) 2015; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland and Radom University in Radom, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 05.06.2015. Revised 15.07.2015. Accepted: 12.08.2015. УДК 616.89:612.017.1 КОМПЛЕКСНАЯ ПСИХОФАРМОКОТЕРАПИЯ ДИСМОРФНЫХ БОЛЕВЫХ ОЩУЩЕНИЙ У ПОДРОСТКОВ С ПСИХИЧЕСКИМИ РАССТРОЙСТВАМИ INTEGRATED PSYCHOPHARMACOTHERAPY DISMORFING PAIN IN ADOLESCENTS WITH PSYCHIATRIC DISORDERS О. В. Чернышов O. V. Chernyshov Николаевская областная психиатрическая больница №1 Mykolaiv Regional Psychiatric Hospital № 1 Summary This article presents the theoretical generalization and the new decision of an actual problem of modern psychiatry - the improvement of the treatment of adolescents with dismorfic painful disorders in the structure of mental disorders by implementing a comprehensive program of pharmacotherapy and psychotherapy, developed on the basis of socio-demographic, clinical, psychopathological, pathopsychological characteristics of patients research. Key words: complex psychopharmacotherapy, psychotherapy, dismorfing pain, mental disorders, adolescents. Резюме В данной статье приведены теоретические обобщения и новое решение актуальной задачи современной психиатрии – усовершенствование системы лечения подростков с дисморфными болевыми ощущениями в структуре психических расстройств, путем внедрения программы комплексной психофармакотерапии и психотерапии, разработанной на основании исследования социально-демографических, клинико-психопатологических и патопсихологических характеристик пациентов. Ключевые слова: комплексная психофармакотерапия, психотерапия, дисморфные болевые ощущения, психические расстройства, подростки.

Aim of investigation. Improvement of results of organ-preserving treatment of early rectal cancer, and assessment of sensitivity and specificity of transrectal ultrasound investigation (TRUS) at these patients.Material and methods. Overall 14 patients with adenocarcinomas (uT1N0) of high or moderate degree of differentiation were selected for transanal endoscopic operation (TEO), as a basic treatment method of villous rectal tumors. Male to female ratio among investigated patients was equal (7/7). Mean tumor size was 2,6±0,8 cm (1,0–4,0 cm). The average distance from the lower pole of tumor to outer edge of anal canal and to dentate line was 7,1±1,7 cm (4,0–9,0 cm) and 4,8±1,9 cm (1,5–7,0 cm) respectively. Preoperative examination included: digital investigation of the rectum, rectoromanoscopy with biopsy, colonoscopy, TRUS, computer tomography and magnetic-resonance tomography of abdominal cavity and small pelvis.Results. The median duration of operation was 39 (25–110) minutes. Tumor-free resection edges have been obtained in all operation specimens. All tumors were removed en bloc. No postoperative morbidity was marked. Preoperative and final diagnoses coincided in all cases. At pathomorphological study adenocarcinoma at Tis stage was revealed in 3 patients (21 %), Т1 — in 10 (71%) and Т2 — in one (8%). In female patient with Т2 adenocarcinoma radical operation was executed, in the removed specimen pararectal lymph node (N1) metastasis was found out. The mean follow-up of patients was 12 (2–20) months, no signs of local tumor relapse were found.Conclusion. TEOs, having minimal morbidity level, are alternative to radical operations at early rectal cancer, however wide utilization of the method is limited by such factors, as depth of neoplasm invasion and involvement of pararectal lymph nodes. Application of TEO should be prudent. Preoperative tumor staging plays the key role.

This article shows that the current roads are considered in conjunction with the environment as an ecological-economic system “roads — road transport — environment”. This approach allows us to estimate the ecological safety of roads in a view of the climatic and economic features of the territories (from protected areas — to very large industrial centers with a high concentration of various industrial sectors), through which the road is paved. However, the development and use of environmental-health monitoring throughout the impact of roads on the overall situation of pollution is not allocated. Our research paying attention to the fallacy of such an approach.

The article deals with communicative language skills and abilities that can be used in teaching senior students and allow to generate a sufficient level of emotional competence of students.

27 injured persons with cranio-cerebral trauma (CCT) were inspected: in 53.4% of them poliorganic insufficiency (PI) was observed at hospitalization, in 27.6% — the syndrome of system inflammatory response (SIRS). Frequency of PI and SIRS origin depends on patients’ age and state according to Glasgow coma scale, trauma severity, concomitant diseases, inflammatory complications. The PI prophylaxis includes infuse therapy with the use of sorbilact and reosorbilact. Application of modern methodology of PI prophylaxis allowed to decrease lethality at CCT.