1. HCV NS5B polymerase inhibitors 2: Synthesis and in vitro activity of (1,1-dioxo-2H-[1,2,4]benzothiadiazin-3-yl) azolo[1,5-a]pyridine and azolo[1,5-a]pyrimidine derivatives
- Author
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Antitsa Dimitrova Stoycheva, Leonid Beigelman, Karl Kossen, P. T. Ravi Rajagopalan, Donald Ruhrmund, Guangyi Wang, Brunella Felicetti, Colin H. MacKinnon, Scott D. Seiwert, Christian A.G.N. Montalbetti, Brad O. Buckman, Debasis Das, Dorian Leo Schönfeld, Huoxing Lei, Thomas Stephen Coulter, John Barker, Jian Hong, Shawn Misialek, Lisa Hooi, Sarah E. Bailey, Xinjie Gai, Wang Xiaofang, Robert K. Y. Cheng, and Richard John Mears
- Subjects
Azoles ,Magnetic Resonance Spectroscopy ,Pyrimidine ,Pyridines ,Stereochemistry ,Chemistry, Pharmaceutical ,viruses ,Clinical Biochemistry ,Pharmaceutical Science ,Hepacivirus ,In Vitro Techniques ,Viral Nonstructural Proteins ,Benzothiadiazines ,Antiviral Agents ,Biochemistry ,Chemical synthesis ,Inhibitory Concentration 50 ,Structure-Activity Relationship ,chemistry.chemical_compound ,Drug Discovery ,Pyridine ,Animals ,Structure–activity relationship ,Enzyme Inhibitors ,Molecular Biology ,Molecular Structure ,biology ,Bicyclic molecule ,Organic Chemistry ,virus diseases ,biochemical phenomena, metabolism, and nutrition ,Hepatitis C ,digestive system diseases ,Pyrimidines ,Models, Chemical ,chemistry ,Benzothiadiazine ,Enzyme inhibitor ,Drug Design ,biology.protein ,Lactam ,Molecular Medicine - Abstract
(1,1-Dioxo-2H-[1,2,4]benzothiadiazin-3-yl) azolo[1,5-a]pyridine and azolo[1,5-a]pyrimidine derivatives have been investigated as potential anti-HCV drugs. Their synthesis, HCV NS5B polymerase inhibition, and replicon activity are discussed.
- Published
- 2009