1,984 results on '"P. Pacini"'
Search Results
2. Development of a High-Resolution, High-Dynamic-Range Charge Detector for Ion Beam Monitoring
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Adriani, O., Berti, E., Betti, P., Casaus, J., DAlessandro, R., Detti, S., Diaz, C., Marin, J., Martinez, G., Mori, N., Pacini, L., Pizzolotto, C., Tiberio, A., Scaringella, M., Starodubtsev, O., Zampa, G., and Zampa, N.
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Physics - Instrumentation and Detectors ,Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
We present an innovative charge detector with high resolution and wide dynamic range designed to fulfill the requirements of a monitoring system for a high energy ion beam. The detector prototype, constructed using Si photodiodes and a custom readout electronics, underwent extensive testing during HERD and AMS beam tests at CERN SPS facilities. Initial testing showcased the detector's exceptional performance, emphasizing both high resolution and a dynamic range capable of measuring nuclei with atomic numbers ranging from 1 to 80. The prototype's compatibility with fast, quasi real-time data analysis qualifies it as an ideal candidate for online applications. This article presents the results from the testing phase of the prototype, highlighting its capabilities and performance. Ongoing detector development, potential applications, and future developments aimed at enhancing the detector's functionality and versatility are also discussed., Comment: 13 pages, 9 figures
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- 2024
3. Maybe you are looking for CroQS: Cross-modal Query Suggestion for Text-to-Image Retrieval
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Pacini, Giacomo, Carrara, Fabio, Messina, Nicola, Tonellotto, Nicola, Amato, Giuseppe, and Falchi, Fabrizio
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Computer Science - Information Retrieval ,Computer Science - Artificial Intelligence ,Computer Science - Machine Learning - Abstract
Query suggestion, a technique widely adopted in information retrieval, enhances system interactivity and the browsing experience of document collections. In cross-modal retrieval, many works have focused on retrieving relevant items from natural language queries, while few have explored query suggestion solutions. In this work, we address query suggestion in cross-modal retrieval, introducing a novel task that focuses on suggesting minimal textual modifications needed to explore visually consistent subsets of the collection, following the premise of ''Maybe you are looking for''. To facilitate the evaluation and development of methods, we present a tailored benchmark named CroQS. This dataset comprises initial queries, grouped result sets, and human-defined suggested queries for each group. We establish dedicated metrics to rigorously evaluate the performance of various methods on this task, measuring representativeness, cluster specificity, and similarity of the suggested queries to the original ones. Baseline methods from related fields, such as image captioning and content summarization, are adapted for this task to provide reference performance scores. Although relatively far from human performance, our experiments reveal that both LLM-based and captioning-based methods achieve competitive results on CroQS, improving the recall on cluster specificity by more than 115% and representativeness mAP by more than 52% with respect to the initial query. The dataset, the implementation of the baseline methods and the notebooks containing our experiments are available here: https://paciosoft.com/CroQS-benchmark/, Comment: 15 pages, 5 figures. To be published as full paper in the Proceedings of the European Conference on Information Retrieval (ECIR) 2025
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- 2024
4. CFD-based design optimization of a 5 kW ducted hydrokinetic turbine with practical constraints
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Park, Jeongbin, Mangano, Marco, Seraj, Sabet, Pacini, Bernardo, Liao, Yingqian, Knight, Bradford G., Naik, Kartik, Maki, Kevin J., Martins, Joaquim R. R. A., Sun, Jing, and Pan, Yulin
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Physics - Fluid Dynamics - Abstract
Ducted hydrokinetic turbines enhance energy-harvesting efficiency by better conditioning the flow to the blades, which may yield higher power output than conventional freestream turbines for the same reference area. In this work, we present a ducted hydrokinetic turbine design obtained by simultaneously optimizing the duct, blade, and hub geometries. Our optimization framework combines a CFD solver, an adjoint solver, and a gradient-based optimizer to efficiently explore a large design space, together with a feature-based parameterization method to handle the complex geometry. Practical geometrical constraints ensure the manufacturability of the duct in terms of a minimum thickness and the housing of a 5 kW generator within the hub. The optimization converges to a short, thin duct with a rounded leading edge and an elongated hub protruding the duct inlet. The optimized ducted turbine achieves up to 50% efficiency when evaluated by RANS/URANS solvers despite a bulky hub, outperforming the 45% efficiency of the freestream Bahaj turbine featuring the same hub. This work showcases the effectiveness of CFD-based optimization in advancing ducted turbine designs and demonstrates the hydrodynamic benefits of a ducted configuration, paving the way for future research and real-world applications., Comment: This work was supported by the US Department of Energy under the award "RAFT: Reconfigurable Array of High-Efficiency Ducted Turbines for Hydrokinetic Energy Harvesting" (Award No. DE-AR0001438)
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- 2024
5. Performance assessment of the HERD calorimeter with a photo-diode read-out system for high-energy electron beams
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Adriani, O., Ambrosi, G., Antonelli, M., Bai, Y., Bai, X., Bao, T., Barbanera, M., Berti, E., Betti, P., Bigongiari, G., Bongi, M., Bonvicini, V., Bottai, S., Cagnoli, I., Cao, W., Casaus, J., Cerasole, D., Chen, Z., Cui, X., D'Alessandro, R., Di Venere, L., Diaz, C., Dong, Y., Detti, S., Duranti, M., Gargano, F., Gao, J., Guo, S., Giovacchini, F., Finetti, N., Formato, V., Jiang, Y., Liang, X., Li, R., Liao, C., Liu, X., Lyu, L., Marin, J., Martinez, G., Mori, N., Oliva, A., Pacini, L., Papini, P., Pillera, R., Pizzolotto, C., Quan, Z., Qin, J. J., Silveri, L., Silvestre, G., Shi, D., Serini, D., Starodubtsev, O., Tang, X., Tiberio, A., Vannuccini, E., Velasco, M., Wang, B., Wang, J., Wang, R., Wang, Z., Xu, M., Yang, X., Zampa, G., Zampa, N., Zhang, S., and Zheng, J.
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Physics - Instrumentation and Detectors ,High Energy Physics - Experiment - Abstract
The measurement of cosmic rays at energies exceeding 100 TeV per nucleon is crucial for enhancing the understanding of high-energy particle propagation and acceleration models in the Galaxy. HERD is a space-borne calorimetric experiment that aims to extend the current direct measurements of cosmic rays to unexplored energies. The payload is scheduled to be installed on the Chinese Space Station in 2027. The primary peculiarity of the instrument is its capability to measure particles coming from all directions, with the main detector being a deep, homogeneous, 3D calorimeter. The active elements are read out using two independent systems: one based on wavelength shifter fibers coupled to CMOS cameras, and the other based on photo-diodes read-out with custom front-end electronics. A large calorimeter prototype was tested in 2023 during an extensive beam test campaign at CERN. In this paper, the performance of the calorimeter for high-energy electron beams, as obtained from the photo-diode system data, is presented. The prototype demonstrated excellent performance, e.g., an energy resolution better than 1% for electrons at 250 GeV. A comparison between beam test data and Monte Carlo simulation data is also presented.
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- 2024
6. A Functional Survey of the Regulatory Landscape of Estrogen Receptor-Positive Breast Cancer Evolution.
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Barozzi, Iros, Slaven, Neil, Canale, Eleonora, Lopes, Rui, Amorim Monteiro Barbosa, Inês, Bleu, Melusine, Ivanoiu, Diana, Pacini, Claudia, Mensa, Emanuela, Chambers, Alfie, Bravaccini, Sara, Ravaioli, Sara, Győrffy, Balázs, Dieci, Maria, Pruneri, Giancarlo, Galli, Giorgio, and Magnani, Luca
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Humans ,Breast Neoplasms ,Female ,Receptors ,Estrogen ,Gene Expression Regulation ,Neoplastic ,Drug Resistance ,Neoplasm ,Antineoplastic Agents ,Hormonal - Abstract
Only a handful of somatic alterations have been linked to endocrine therapy resistance in hormone-dependent breast cancer, potentially explaining ∼40% of relapses. If other mechanisms underlie the evolution of hormone-dependent breast cancer under adjuvant therapy is currently unknown. In this work, we employ functional genomics to dissect the contribution of cis-regulatory elements (CRE) to cancer evolution by focusing on 12 megabases of noncoding DNA, including clonal enhancers, gene promoters, and boundaries of topologically associating domains. Parallel epigenetic perturbation (CRISPRi) in vitro reveals context-dependent roles for many of these CREs, with a specific impact on dormancy entrance and endocrine therapy resistance. Profiling of CRE somatic alterations in a unique, longitudinal cohort of patients treated with endocrine therapies identifies a limited set of noncoding changes potentially involved in therapy resistance. Overall, our data uncover how endocrine therapies trigger the emergence of transient features which could ultimately be exploited to hinder the adaptive process. Significance: This study shows that cells adapting to endocrine therapies undergo changes in the usage or regulatory regions. Dormant cells are less vulnerable to regulatory perturbation but gain transient dependencies which can be exploited to decrease the formation of dormant persisters.
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- 2024
7. Functional Decomposition and Estimation of Irreversibility in Time Series via Machine Learning
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Vodret, Michele, Pacini, Cristiano, and Bongiorno, Christian
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Condensed Matter - Statistical Mechanics - Abstract
This work introduces a novel, simple, and flexible method to quantify irreversibility in generic high-dimensional time series based on the well-known mapping to a binary classification problem. Our approach utilizes gradient boosting for estimation, providing a model-free, nonlinear analysis able to handle large-dimensional systems while requiring minimal or no calibration. Our procedure is divided into three phases: trajectory encoding, Markovian order identification, and hypothesis testing for variable interactions. The latter is the key innovation that allows us to selectively switch off variable interactions to discern their specific contribution to irreversibility. When applied to financial markets, our findings reveal a distinctive shift: during stable periods, irreversibility is mainly related to short-term patterns, whereas in unstable periods, these short-term patterns are disrupted, leaving only contributions from stable long-term ones. This observed transition underscores the crucial importance of high-order variable interactions in understanding the dynamics of financial markets, especially in times of turbulence.
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- 2024
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8. Separation Power of Equivariant Neural Networks
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Pacini, Marco, Dong, Xiaowen, Lepri, Bruno, and Santin, Gabriele
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Computer Science - Machine Learning ,Computer Science - Artificial Intelligence - Abstract
The separation power of a machine learning model refers to its ability to distinguish between different inputs and is often used as a proxy for its expressivity. Indeed, knowing the separation power of a family of models is a necessary condition to obtain fine-grained universality results. In this paper, we analyze the separation power of equivariant neural networks, such as convolutional and permutation-invariant networks. We first present a complete characterization of inputs indistinguishable by models derived by a given architecture. From this results, we derive how separability is influenced by hyperparameters and architectural choices-such as activation functions, depth, hidden layer width, and representation types. Notably, all non-polynomial activations, including ReLU and sigmoid, are equivalent in expressivity and reach maximum separation power. Depth improves separation power up to a threshold, after which further increases have no effect. Adding invariant features to hidden representations does not impact separation power. Finally, block decomposition of hidden representations affects separability, with minimal components forming a hierarchy in separation power that provides a straightforward method for comparing the separation power of models., Comment: 10 pages of main text, 1 figure
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- 2024
9. The Impact of Fines on Deceptive Advertising: Evidence from Italy
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Mangani, Andrea and Pacini, Barbara
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- 2024
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10. Single-port transvesical simple prostatectomy for the surgical treatment of benign prostatic hyperplasia: functional and continence outcomes
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Pacini, Matteo, Lambertini, Luca, Avesani, Giulio, Torres Anguiano, Juan R., Morgantini, Luca, Martin, Alec, Sauer Calvo, Ruben, Haberal, Hakan B., Bignante, Gabriele, Minervini, Andrea, Zucchi, Alessandro, Bartoletti, Riccardo, and Crivellaro, Simone
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- 2024
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11. Aspergillus calidoustus and Talaromyces columbinus infections in chronic graft-versus-host disease
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Pacini, Emanuele, Schelenz, Silke, Abdolrasouli, Alireza, Mehra, Varun, Ceesay, M. Mansour, Pagliuca, Antonio, and Avenoso, Daniele
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- 2024
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12. Lost in Translation? Cultural Adaptation of Child Mental Health Interventions in Nepal: A Systematic Review
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Pacini, Adele, Broker, Hayley, and Shrestha, Prithvi
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- 2024
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13. MRI in the evaluation of plantar plate disease: diagnostic value of the “stress test”
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Giuliani, Luca, Ottonello, Carlo, Giuliani, Alessandra, Bondì, Lucia, Ronconi, Paolo, Tempesta, Valerio, Pacini, Patrizia, and Cantisani, Vito
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- 2024
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14. Synthetic augmentation of cancer cell line multi-omic datasets using unsupervised deep learning
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Cai, Zhaoxiang, Apolinário, Sofia, Baião, Ana R., Pacini, Clare, Sousa, Miguel D., Vinga, Susana, Reddel, Roger R., Robinson, Phillip J., Garnett, Mathew J., Zhong, Qing, and Gonçalves, Emanuel
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- 2024
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15. Development and validation of a novel comorbidity score specific for prostate cancer patients treated with robotic platform and its implication on DaVinci single-port system
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Cannoletta, Donato, Mazzone, Elio, Dell’Oglio, Paolo, Pettenuzzo, Greta, Pacini, Matteo, Lambertini, Luca, Pellegrino, Antony Angelo, Sauer, Ruben Calvo, Torres-Anguiano, Juan R., Stabile, Armando, Pellegrino, Francesco, Gandaglia, Giorgio, Bartoletti, Riccardo, Minervini, Andrea, Antonelli, Alessandro, Montorsi, Francesco, Briganti, Alberto, and Crivellaro, Simone
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- 2024
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16. Multimodal phenotyping of foveal hypoplasia in albinism and albino-like conditions: a pediatric case series with adaptive optics insights
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Bacci, Giacomo M., Marziali, Elisa, Bargiacchi, Sara, Paques, Michel, Virgili, Gianni, Fortunato, Pina, Durand, Marine, Rocca, Camilla, Pagliazzi, Angelica, Palazzo, Viviana, Tiberi, Lucia, Vergani, Debora, Landini, Samuela, Peron, Angela, Artuso, Rosangela, Pacini, Bianca, Stabile, Monica, Sodi, Andrea, and Caputo, Roberto
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- 2024
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17. Publisher Correction: First large-scale study reveals important losses of managed honey bee and stingless bee colonies in Latin America
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Requier, Fabrice, Leyton, Malena Sibaja, Morales, Carolina L., Garibaldi, Lucas A., Giacobino, Agostina, Porrini, Martin Pablo, Rosso-Londoño, Juan Manuel, Velarde, Rodrigo A., Aignasse, Andrea, Aldea-Sánchez, Patricia, Allasino, Mariana Laura, Arredondo, Daniela, Audisio, Carina, Cagnolo, Natalia Bulacio, Basualdo, Marina, Branchiccela, Belén, Calderón, Rafael A., Castelli, Loreley, Castilhos, Dayson, Escareño, Francisca Contreras, Correa-Benítez, Adriana, da Silva, Fabiana Oliveira, Garnica, Diego Silva, de Groot, Grecia, Delgado-Cañedo, Andres, Fernández-Marín, Hermógenes, Freitas, Breno M., Galindo-Cardona, Alberto, Garcia, Nancy, Garrido, Paula M., Giray, Tugrul, Gonçalves, Lionel Segui, Landi, Lucas, Malusá Gonçalves, Daniel, Martinez, Silvia Inés, Moja, Pablo Joaquín, Molineri, Ana, Müller, Pablo Fernando, Nogueira, Enrique, Pacini, Adriana, Palacio, María Alejandra, Parra, Guiomar Nates, Parra-H, Alejandro, Peres Gramacho, Kátia, Castro, Eleazar Pérez, Pires, Carmen Sílvia Soares, Reynaldi, Francisco J., Luis, Anais Rodríguez, Rossini, Carmen, Sánchez Armijos, Milton, Santos, Estela, Scannapieco, Alejandra, Spina, Yamandú Mendoza, Tapia González, José María, Vargas Fernández, Andrés Marcelo, Viana, Blandina Felipe, Vieli, Lorena, Yadró García, Carlos Ariel, and Antúnez, Karina
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- 2024
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18. BRIX: an autonomous system for brick wall construction
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Ruttico, Pierpaolo, Pacini, Matteo, and Beltracchi, Carlo
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- 2024
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19. An in-silico modeling approach to separate exogenous and endogenous plasma insulin appearance, with application to inhaled insulin
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Piersanti, Agnese, Pacini, Giovanni, Tura, Andrea, D’Argenio, David Z., and Morettini, Micaela
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- 2024
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20. Correction: In search of traces of the mandrake myth: the historical, and ethnobotanical roots of its vernacular names
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Dafni, Amots, Blanché, Cesar, Khatib, Salekh Aqil, Petanidou, Theodora, Aytaç, Bedrettin, Pacini, Ettore, Kozuharova, Ekaterina, Geva-Kleinberger, Aharon, Shahvar, Soli, Dajic, Zora, Klug, Helmut W., and Benítez, Guillermo
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- 2024
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21. First large-scale study reveals important losses of managed honey bee and stingless bee colonies in Latin America
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Requier, Fabrice, Leyton, Malena Sibaja, Morales, Carolina L., Garibaldi, Lucas A., Giacobino, Agostina, Porrini, Martin Pablo, Rosso-Londoño, Juan Manuel, Velarde, Rodrigo A., Aignasse, Andrea, Aldea-Sánchez, Patricia, Allasino, Mariana Laura, Arredondo, Daniela, Audisio, Carina, Cagnolo, Natalia Bulacio, Basualdo, Marina, Branchiccela, Belén, Calderón, Rafael A., Castelli, Loreley, Castilhos, Dayson, Escareño, Francisca Contreras, Correa-Benítez, Adriana, da Silva, Fabiana Oliveira, Garnica, Diego Silva, de Groot, Grecia, Delgado-Cañedo, Andres, Fernández-Marín, Hermógenes, Freitas, Breno M., Galindo-Cardona, Alberto, Garcia, Nancy, Garrido, Paula M., Giray, Tugrul, Gonçalves, Lionel Segui, Landi, Lucas, Malusá Gonçalves, Daniel, Martinez, Silvia Inés, Moja, Pablo Joaquín, Molineri, Ana, Müller, Pablo Fernando, Nogueira, Enrique, Pacini, Adriana, Palacio, María Alejandra, Parra, Guiomar Nates, Parra-H, Alejandro, Peres Gramacho, Kátia, Castro, Eleazar Pérez, Pires, Carmen Sílvia Soares, Reynaldi, Francisco J., Luis, Anais Rodríguez, Rossini, Carmen, Sánchez Armijos, Milton, Santos, Estela, Scannapieco, Alejandra, Spina, Yamandú Mendoza, Tapia González, José María, Vargas Fernández, Andrés Marcelo, Viana, Blandina Felipe, Vieli, Lorena, Yadró García, Carlos Ariel, and Antúnez, Karina
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- 2024
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22. Correction: VEGF-A/VEGFR-1 signalling and chemotherapy-induced neuropathic pain: therapeutic potential of a novel anti-VEGFR-1 monoclonal antibody
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Micheli, Laura, Parisio, Carmen, Lucarini, Elena, Vona, Alessia, Toti, Alessandra, Pacini, Alessandra, Mello, Tommaso, Boccella, Serena, Ricciardi, Flavia, Maione, Sabatino, Graziani, Grazia, Lacal, Pedro Miguel, Failli, Paola, Ghelardini, Carla, and Di Cesare Mannelli, Lorenzo
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- 2024
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23. Impact of cattle density on the structure and natural regeneration of a turkey oak stand on an agrosilvopastoral farm in central Italy
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Pacini, Alessandra, Pelleri, Francesco, Marini, Francesco, Maltoni, Alberto, Mariotti, Barbara, Mazza, Gianluigi, and Manetti, Maria Chiara
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- 2024
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24. Direct Measurement of the Spectral Structure of Cosmic-Ray Electrons+Positrons in the TeV Region with CALET on the International Space Station
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Adriani, O., Akaike, Y., Asano, K., Asaoka, Y., Berti, E., Bigongiari, G., Binns, W. R., Bongi, M., Brogi, P., Bruno, A., Buckley, J. H., Cannady, N., Castellini, G., Checchia, C., Cherry, M. L., Collazuol, G., de Nolfo, G. A., Ebisawa, K., Ficklin, A. W., Fuke, H., Gonzi, S., Guzik, T. G., Hams, T., Hibino, K., Ichimura, M., Ioka, K., Ishizaki, W., Israel, M. H., Kasahara, K., Kataoka, J., Kataoka, R., Katayose, Y., Kato, C., Kawanaka, N., Kawakubo, Y., Kobayashi, K., Kohri, K., Krawczynski, H. S., Krizmanic, J. F., Maestro, P., Marrocchesi, P. S., Messineo, A. M., Mitchell, J. W., Miyake, S., Moiseev, A. A., Mori, M., Mori, N., Motz, H. M., Munakata, K., Nakahira, S., Nishimura, J., Okuno, S., Ormes, J. F., Ozawa, S., Pacini, L., Papini, P., Rauch, B. F., Ricciarini, S. B., Sakai, K., Sakamoto, 3 T., Sasaki, M., Shimizu, Y., Shiomi, A., Spillantini, P., Stolzi, F., Sugita, S., Sulaj, A., Takita, M., Tamura, T., Terasawa, T., Torii, S., Tsunesada, Y., Uchihori, Y., Vannuccini, E., Wefel, J. P., Yamaoka, K., Yanagita, S., Yoshida, A., Yoshida, K., and Zober, W. V.
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
Detailed measurements of the spectral structure of cosmic-ray electrons and positrons from 10.6 GeV to 7.5 TeV are presented from over 7 years of observations with the CALorimetric Electron Telescope (CALET) on the International Space Station. Because of the excellent energy resolution (a few percent above 10 GeV) and the outstanding e/p separation (10$^5$), CALET provides optimal performance for a detailed search of structures in the energy spectrum. The analysis uses data up to the end of 2022, and the statistics of observed electron candidates has increased more than 3 times since the last publication in 2018. By adopting an updated boosted decision tree analysis, a sufficient proton rejection power up to 7.5 TeV is achieved, with a residual proton contamination less than 10%. The observed energy spectrum becomes gradually harder in the lower energy region from around 30 GeV, consistently with AMS-02, but from 300 to 600 GeV it is considerably softer than the spectra measured by DAMPE and Fermi-LAT. At high energies, the spectrum presents a sharp break around 1 TeV, with a spectral index change from -3.15 to -3.91, and a broken power law fitting the data in the energy range from 30 GeV to 4.8 TeV better than a single power law with 6.9 sigma significance, which is compatible with the DAMPE results. The break is consistent with the expected effects of radiation loss during the propagation from distant sources (except the highest energy bin). We have fitted the spectrum with a model consistent with the positron flux measured by AMS-02 below 1 TeV and interpreted the electron + positron spectrum with possible contributions from pulsars and nearby sources. Above 4.8 TeV, a possible contribution from known nearby supernova remnants, including Vela, is addressed by an event-by-event analysis providing a higher proton-rejection power than a purely statistical analysis., Comment: main text: 7 pages, 4 figures; supplemental material: 10 pages, 8 figures, 1 table
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- 2023
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25. A Torelli theorem for graphs via quasistable divisors
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Abreu, Alex and Pacini, Marco
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Mathematics - Combinatorics ,Mathematics - Algebraic Geometry - Abstract
The Torelli theorem establishes that the Jacobian of a smooth projective curve, together with the polarization provided by the theta divisor, fully characterizes the curve. In the case of nodal curves, there exists a concept known as fine compactified Jacobian. The fine compactified Jacobian of a curve comes with a natural stratification that can be regarded as a poset. Furthermore, this poset is entirely determined by the dual graph of the curve and is referred to as the poset of quasistable divisors on the graph. We present a combinatorial version of the Torelli theorem, which demonstrates that the poset of quasistable divisors of a graph completely determines the biconnected components of the graph (up to contracting separating edges). Moreover, we achieve a natural extension of this theorem to tropical curves., Comment: MSC: 05Cxx, 14Hxx. 22 pages
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- 2023
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26. Effects of Consuming Beverages Sweetened with Fructose, Glucose, High-Fructose Corn Syrup, Sucrose, or Aspartame on OGTT-Derived Indices of Insulin Sensitivity in Young Adults
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Hieronimus, Bettina, Medici, Valentina, Lee, Vivien, Nunez, Marinelle V, Sigala, Desiree M, Bremer, Andrew A, Cox, Chad L, Keim, Nancy L, Schwarz, Jean-Marc, Pacini, Giovanni, Tura, Andrea, Havel, Peter J, and Stanhope, Kimber L
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Biomedical and Clinical Sciences ,Nutrition and Dietetics ,Clinical Sciences ,Nutrition ,Diabetes ,Metabolic and endocrine ,Young Adult ,Humans ,Glucose ,Glucose Tolerance Test ,Aspartame ,Insulin Resistance ,Zea mays ,Sucrose ,Fructose ,High Fructose Corn Syrup ,Beverages ,Insulin ,dietary intervention study ,fructose ,glucose ,high-fructose corn syrup ,sucrose ,aspartame ,insulin sensitivity index ,insulin resistance ,hepatic insulin sensitivity ,muscle insulin sensitivity ,Food Sciences ,Clinical sciences ,Nutrition and dietetics ,Public health - Abstract
(1) Background: Clinical results on the effects of excess sugar consumption on insulin sensitivity are conflicting, possibly due to differences in sugar type and the insulin sensitivity index (ISI) assessed. Therefore, we compared the effects of consuming four different sugars on insulin sensitivity indices derived from oral glucose tolerance tests (OGTT). (2) Methods: Young adults consumed fructose-, glucose-, high-fructose corn syrup (HFCS)-, sucrose-, or aspartame-sweetened beverages (SB) for 2 weeks. Participants underwent OGTT before and at the end of the intervention. Fasting glucose and insulin, Homeostatic Model Assessment-Insulin Resistance (HOMA-IR), glucose and insulin area under the curve, Surrogate Hepatic Insulin Resistance Index, Matsuda ISI, Predicted M ISI, and Stumvoll Index were assessed. Outcomes were analyzed to determine: (1) effects of the five SB; (2) effects of the proportions of fructose and glucose in all SB. (3) Results: Fructose-SB and the fructose component in mixed sugars negatively affected outcomes that assess hepatic insulin sensitivity, while glucose did not. The effects of glucose-SB and the glucose component in mixed sugar on muscle insulin sensitivity were more negative than those of fructose. (4) Conclusion: the effects of consuming sugar-SB on insulin sensitivity varied depending on type of sugar and ISI index because outcomes assessing hepatic insulin sensitivity were negatively affected by fructose, and outcomes assessing muscle insulin sensitivity were more negatively affected by glucose.
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- 2024
27. Computing Effective Mass Using the Modal Craig Bampton Framework
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Pacini, B. R. and Mayes, R. L.
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- 2024
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28. CFD-based Design Optimization of Ducted Hydrokinetic Turbines
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Park, Jeongbin, Knight, Bradford G., Liao, Yingqian, Mangano, Marco, Pacini, Bernardo, Maki, Kevin J., Martins, Joaquim R. R. A., Sun, Jing, and Pan, Yulin
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Physics - Fluid Dynamics - Abstract
Hydrokinetic turbines extract kinetic energy from moving water to generate renewable electricity, thus contributing to sustainable energy production and reducing reliance on fossil fuels. It has been hypothesized that a duct can accelerate and condition the fluid flow passing the turbine blades, improving the overall energy extraction efficiency. However, no substantial evidence has been provided so far for hydrokinetic turbines. To investigate this problem, we perform a CFD-based optimization study with a blade-resolved Reynolds-averaged Navier--Stokes (RANS) solver to explore the design of a ducted hydrokinetic turbine that maximizes the efficiency of energy extraction. To handle the high-dimensional design space of the blade and duct geometry, we use a gradient-based optimization approach where the gradients are computed using the adjoint method. The final design is re-evaluated through higher-fidelity unsteady RANS (URANS) simulations. Our optimized ducted turbine achieves an efficiency of about 54% over a range of operating conditions, higher than the typical 46% efficiency of unducted turbines such as the well-known Bahaj model.
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- 2023
29. Storying with Plastic Excess: Relations with Plastic in Early Childhood Education
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Kelly-Ann Macalpine and Veronica Pacini-Ketchabaw
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The earth is drowning in plastic waste. Yet, as the plastic waste crisis grows exponentially, responses to excess waste remain stuck around containment and management processes. These approaches fail to notice that plastics know no boundaries. We now encounter plastic rocks, plastic water, plastic bodies, plastic worlds spilling into oceans and rivers and across landscapes. Responding to the complexity of plastic's unruly presence demands careful attention both globally and within situated local contexts. This article explores how the queer synthetic curriculum takes up the concept of excess through common worlding waste pedagogies to attend to children's relations with plastic waste. We speculate with the idea of excess by making large amounts of plastic the main protagonist in an early childhood classroom. Disrupting waste management's metaphors of distance, we exaggerate plastic's presence: a plastic whale stomach is stuffed with plastic bottles, dozens of bottles hang from the ceiling, hundreds of bottles are strewn across the classroom floor, and crochet hooks turn out plastic yarn balls. Without claiming to develop children's understanding of the problematic nature of waste, this article stories moments of excess that might provoke subjective transformations as children encounter excess in their daily lives.
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- 2024
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30. Learnings from rapid response efforts to remotely detect landslides triggered by the August 2021 Nippes earthquake and Tropical Storm Grace in Haiti
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Amatya, Pukar, Scheip, Corey, Déprez, Aline, Malet, Jean-Philippe, Slaughter, Stephen L, Handwerger, Alexander L, Emberson, Robert, Kirschbaum, Dalia, Jean-Baptiste, Julien, Huang, Mong-Han, Clark, Marin K, Zekkos, Dimitrios, Huang, Jhih-Rou, Pacini, Fabrizio, and Boissier, Enguerran
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Earth Sciences ,Physical Geography and Environmental Geoscience ,Nippes earthquake ,Tropical Storm Grace ,Haiti ,Landslides ,Rapid response ,Satellite imagery ,Atmospheric Sciences ,Psychology ,Strategic ,Defence & Security Studies ,Physical geography and environmental geoscience - Abstract
On August 14, 2021, a Mw 7.2 earthquake struck the Tiburon Peninsula of western Haiti triggering thousands of landslides. Three days after the earthquake on August 17, 2021, Tropical Storm Grace crossed shallow waters offshore of southern Haiti triggering more landslides worsening the situation. In the aftermath of these events, several organizations with disaster response capabilities or programs activated to provide information on the location of landslides to first responders on the ground. Utilizing remote sensing to support rapid response, one organization manually mapped initiation point of landslides and three automatically detected landslides. The 2021 Haiti event also provided a unique opportunity to test different automated landslide detection methods that utilized both SAR and optical data in a rapid response scenario where rapid situational awareness was critical. As the methods used are highly replicable, the main goal of this study is to summarize the landslide rapid response products released by the organizations, detection methods, quantify accuracy and provide guidelines on how some of the shortcomings encountered in this effort might be addressed in the future. To support this validation, a manually mapped polygon-based landslide inventory covering the entire affected area was created and is also released through this effort.
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- 2023
31. Charge-Sign Dependent Cosmic-Ray Modulation Observed with the Calorimetric Electron Telescope on the International Space Station
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Adriani, O., Akaike, Y., Asano, K., Asaoka, Y., Berti, E., Bigongiari, G., Binns, W. R., Bongi, M., Brogi, P., Bruno, A., Buckley, J. H., Cannady, N., Castellini, G., Checchia, C., Cherry, M. L., Collazuol, G., de Nolfo, G. A., Ebisawa, K., Ficklin, A. W., Fuke, H., Gonzi, S., Guzik, T. G., Hams, T., Hibino, K., Ichimura, M., Ioka, K., Ishizaki, W., Israel, M. H., Kasahara, K., Kataoka, J., Kataoka, R., Katayose, Y., Kato, C., Kawanaka, N., Kawakubo, Y., Kobayashi, K., Kohri, K., Krawczynski, H. S., Krizmanic, J. F., Maestro, P., Marrocchesi, P. S., Messineo, A. M., Mitchell, J. W., Miyake, S., Moiseev, A. A., Mori, M., Mori, N., Motz, H. M., Munakata, K., Nakahira, S., Nishimura, J., Okuno, S., Ormes, J. F., Ozawa, S., Pacini, L., Papini, P., Rauch, B. F., Ricciarini, S. B., Sakai, K., Sakamoto, T., Sasaki, M., Shimizu, Y., Shiomi, A., Spillantini, P., Stolzi, F., Sugita, S., Sulaj, A., Takita, M., Tamura, T., Terasawa, T., Torii, S., Tsunesada, Y., Uchihori, Y., Vannuccini, E., Wefel, J. P., Yamaoka, K., Yanagita, S., Yoshida, A., Yoshida, K., and Zober, W. V.
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
We present the observation of a charge-sign dependent solar modulation of galactic cosmic rays (GCRs) with the CALorimetric Electron Telescope onboard the International Space Station over 6 yr, corresponding to the positive polarity of the solar magnetic field. The observed variation of proton count rate is consistent with the neutron monitor count rate, validating our methods for determining the proton count rate. It is observed by the CALorimetric Electron Telescope that both GCR electron and proton count rates at the same average rigidity vary in anticorrelation with the tilt angle of the heliospheric current sheet, while the amplitude of the variation is significantly larger in the electron count rate than in the proton count rate. We show that this observed charge-sign dependence is reproduced by a numerical ``drift model'' of the GCR transport in the heliosphere. This is a clear signature of the drift effect on the long-term solar modulation observed with a single detector., Comment: main text: 6 pages, 3 figures, supplemental material: 8 pages, 3 figures, 1 table
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- 2023
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32. Direct Measurement of the Cosmic-Ray Helium Spectrum from 40 GeV to 250 TeV with the Calorimetric Electron Telescope on the International Space Station
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Adriani, O., Akaike, Y., Asano, K., Asaoka, Y., Berti, E., Bigongiari, G., Binns, W. R., Bongi, M., Brogi, P., Bruno, A., Buckley, J. H., Cannady, N., Castellini, G., Checchia, C., Cherry, M. L., Collazuol, G., de Nolfo, G. A., Ebisawa, K., Ficklin, A. W., Fuke, H., Gonzi, S., Guzik, T. G., Hams, T., Hibino, K., Ichimura, M., Ioka, K., Ishizaki, W., Israel, M. H., Kasahara, K., Kataoka, J., Kataoka, R., Katayose, Y., Kato, C., Kawanaka, N., Kawakubo, Y., Kobayashi, K., Kohri, K., Krawczynski, H. S., Krizmanic, J. F., Maestro, P., Marrocchesi, P. S., Messineo, A. M., Mitchell, J. W., Miyake, S., Moiseev, A. A., Mori, M., Mori, N., Motz, H. M., Munakata, K., Nakahira, S., Nishimura, J., Okuno, S., Ormes, J. F., Ozawa, S., Pacini, L., Papini, P., Rauch, B. F., Ricciarini, S. B., Sakai, K., Sakamoto, T., Sasaki, M., Shimizu, Y., Shiomi, A., Spillantini, P., Stolzi, F., Sugita, S., Sulaj, A., Takita, M., Tamura, T., Terasawa, T., Torii, S., Tsunesada, Y., Uchihori, Y., Vannuccini, E., Wefel, J. P., Yamaoka, K., Yanagita, S., Yoshida, A., Yoshida, K., and Zober, W. V.
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
We present the results of a direct measurement of the cosmic-ray helium spectrum with the CALET instrument in operation on the International Space Station since 2015. The observation period covered by this analysis spans from October 13, 2015 to April 30, 2022 (2392 days). The very wide dynamic range of CALET allowed to collect helium data over a large energy interval, from ~40 GeV to ~250 TeV, for the first time with a single instrument in Low Earth Orbit. The measured spectrum shows evidence of a deviation of the flux from a single power-law by more than 8$\sigma$ with a progressive spectral hardening from a few hundred GeV to a few tens of TeV. This result is consistent with the data reported by space instruments including PAMELA, AMS-02, DAMPE and balloon instruments including CREAM. At higher energy we report the onset of a softening of the helium spectrum around 30 TeV (total kinetic energy). Though affected by large uncertainties in the highest energy bins, the observation of a flux reduction turns out to be consistent with the most recent results of DAMPE. A Double Broken Power Law (DBPL) is found to fit simultaneously both spectral features: the hardening (at lower energy) and the softening (at higher energy). A measurement of the proton to helium flux ratio in the energy range from 60 GeV/n to about 60 TeV/n is also presented, using the CALET proton flux recently updated with higher statistics.
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- 2023
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33. Accurate multiscale simulation of frictional interfaces by Quantum Mechanics/Green's Function molecular dynamics
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Kajita, Seiji, Pacini, Alberto, Losi, Gabriele, Kikkawa, Nobuaki, and Righi, Maria Clelia
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Condensed Matter - Mesoscale and Nanoscale Physics ,Physics - Computational Physics - Abstract
Understanding frictional phenomena is a fascinating fundamental problem with huge potential impact on energy saving. Such an understanding requires monitoring what happens at the sliding buried interface, which is almost inaccessible by experiments. Simulations represent powerful tools in this context, yet a methodological step forward is needed to fully capture the multiscale nature of the frictional phenomena. Here, we present a multiscale approach based on linked ab initio and Green's function molecular dynamics, which is above the state-of-the-art techniques used in computational tribology as it allows for a realistic description of both the interfacial chemistry and energy dissipation due to bulk phonons in non-equilibrium conditions. By considering a technologically relevant system composed of two diamond surfaces with different degrees of passivation, we show that the presented method can be used not only for monitoring in real-time tribolochemical phenomena such as the tribologically-induced surface graphitization and passivation effects but also for estimating realistic friction coefficients. This opens the way to in silico experiments of tribology to test materials to reduce friction prior to that in real labs.
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- 2023
34. Unintentional pediatric exposures to household cleaning products: a cross-sectional analysis of the National Poison Data System (2000-2015).
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Pacini, Anthony, Tsutaoka, Ben, Lai, Leslie, and Durrani, Timur
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Cleaning products ,Household ,Pediatric ,Poisoning ,Prevention - Abstract
BACKGROUND: Household cleaning products are the second most common cause of unintentional poisoning in children
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- 2023
35. Cosmic-ray Boron Flux Measured from 8.4 GeV$/n$ to 3.8 TeV$/n$ with the Calorimetric Electron Telescope on the International Space Station
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Adriani, O., Akaike, Y., Asano, K., Asaoka, Y., Berti, E., Bigongiari, G., Binns, W. R., Bongi, M., Brogi, P., Bruno, A., Buckley, J. H., Cannady, N., Castellini, G., Checchia, C., Cherry, M. L., Collazuol, G., de Nolfo, G. A., Ebisawa, K., Ficklin, A. W., Fuke, H., Gonzi, S., Guzik, T. G., Hams, T., Hibino, K., Ichimura, M., Ioka, K., Ishizaki, W., Israel, M. H., Kasahara, K., Kataoka, J., Kataoka, R., Katayose, Y., Kato, C., Kawanaka, N., Kawakubo, Y., Kobayashi, K., Kohri, K., Krawczynski, H. S., Krizmanic, J. F., Maestro, P., Marrocchesi, P. S., Messineo, A. M., Mitchell, J. W., Miyake, S., Moiseev, A. A., Mori, M., Mori, N., Motz, H. M., Munakata, K., Nakahira, S., Nishimura, J., Okuno, S., Ormes, J. F., Ozawa, S., Pacini, L., Papini, P., Rauch, B. F., Ricciarini, S. B., Sakai, K., Sakamoto, T., Sasaki, M., Shimizu, Y., Shiomi, A., Spillantini, P., Stolzi, F., Sugita, S., Sulaj, A., Takita, M., Tamura, T., Terasawa, T., Torii, S., Tsunesada, Y., Uchihori, Y., Vannuccini, E., Wefel, J. P., Yamaoka, K., Yanagita, S., Yoshida, A., Yoshida, K., and Zober, W. V.
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
We present the measurement of the energy dependence of the boron flux in cosmic rays and its ratio to the carbon flux \textcolor{black}{in an energy interval from 8.4 GeV$/n$ to 3.8 TeV$/n$} based on the data collected by the CALorimetric Electron Telescope (CALET) during $\sim 6.4$ years of operation on the International Space Station. An update of the energy spectrum of carbon is also presented with an increase in statistics over our previous measurement. The observed boron flux shows a spectral hardening at the same transition energy $E_0 \sim 200$ GeV$/n$ of the C spectrum, though B and C fluxes have different energy dependences. The spectral index of the B spectrum is found to be $\gamma = -3.047\pm0.024$ in the interval $25 < E < 200$ GeV$/n$. The B spectrum hardens by $\Delta \gamma_B=0.25\pm0.12$, while the best fit value for the spectral variation of C is $\Delta \gamma_C=0.19\pm0.03$. The B/C flux ratio is compatible with a hardening of $0.09\pm0.05$, though a single power-law energy dependence cannot be ruled out given the current statistical uncertainties. A break in the B/C ratio energy dependence would support the recent AMS-02 observations that secondary cosmic rays exhibit a stronger hardening than primary ones. We also perform a fit to the B/C ratio with a leaky-box model of the cosmic-ray propagation in the Galaxy in order to probe a possible residual value $\lambda_0$ of the mean escape path length $\lambda$ at high energy. We find that our B/C data are compatible with a non-zero value of $\lambda_0$, which can be interpreted as the column density of matter that cosmic rays cross within the acceleration region., Comment: main text: 7 pages, 3 figures; supplemental material: 13 pages, 8 figures, 3 tables
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- 2022
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36. Observation of Spectral Structures in the Flux of Cosmic-Ray Protons from 50 GeV to 60 TeV with the Calorimetric Electron Telescope on the International Space Station
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Adriani, O., Akaike, Y., Asano, K., Asaoka, Y., Berti, E., Bigongiari, G., Binns, W. R., Bongi, M., Brogi, P., Bruno, A., Buckley, J. H., Cannady, N., Castellini, G., Checchia, C., Cherry, M. L., Collazuol, G., Ebisawa, K., Ficklin, A. W., Fuke, H., Gonzi, S., Guzik, T. G., Hams, T., Hibino, K., Ichimura, M., Ioka, K., Ishizaki, W., Israel, M. H., Kasahara, K., Kataoka, J., Kataoka, R., Katayose, Y., Kato, C., Kawanaka, N., Kawakubo, Y., Kobayashi, K., Kohri, K., Krawczynski, H. S., Krizmanic, J. F., Maestro, P., Marrocchesi, P. S., Messineo, A. M., Mitchell, J. W., Miyake, S., Moiseev, A. A., Mori, M., Mori, N., Motz, H. M., Munakata, K., Nakahira, S., Nishimura, J., de Nolfo, G. A., Okuno, S., Ormes, J. F., Ozawa, S., Pacini, L., Papini, P., Rauch, B. F., Ricciarini, S. B., Sakai, K., Sakamoto, T., Sasaki, M., Shimizu, Y., Shiomi, A., Spillantini, P., Stolzi, F., Sugita, S., Sulaj, A., Takita, M., Tamura, T., Terasawa, T., Torii, S., Tsunesada, Y., Uchihori, Y., Vannuccini, E., Wefel, J. P., Yamaoka, K., Yanagita, S., Yoshida, A., Yoshida, K., and Zober, W. V.
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
A precise measurement of the cosmic-ray proton spectrum with the Calorimetric Electron Telescope (CALET) is presented in the energy interval from 50 GeV to 60 TeV, and the observation of a softening of the spectrum above 10 TeV is reported. The analysis is based on the data collected during $\sim$6.2 years of smooth operations aboard the International Space Station and covers a broader energy range with respect to the previous proton flux measurement by CALET, with an increase of the available statistics by a factor of $\sim$2.2. Above a few hundred GeV we confirm our previous observation of a progressive spectral hardening with a higher significance (more than 20 sigma). In the multi-TeV region we observe a second spectral feature with a softening around 10 TeV and a spectral index change from =2.6 to -2.9 consistently, within the errors, with the shape of the spectrum reported by DAMPE. We apply a simultaneous fit of the proton differential spectrum which well reproduces the gradual change of the spectral index encompassing the lower energy power-law regime and the two spectral features observed at higher energies., Comment: main text: 8 pages, 5 figures, supplemental material: 9 pages, 7 figures, 1 table, marked as a PRL Editor's Suggestion
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- 2022
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37. A Systematic Review and Characterization of the Major and Most Studied Urban Soil Threats in the European Union
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Binner, Hannah, Wojda, Piotr, Yunta, Felipe, Breure, Timo, Schievano, Andrea, Massaro, Emanuele, Jones, Arwyn, Newell, Jennifer, Paradelo, Remigio, Popescu Boajă, Iustina, Baltrėnaitė-Gedienė, Edita, Tuttolomondo, Teresa, Iacuzzi, Nicolò, Bondi, Giulia, Zupanc, Vesna, Mamy, Laure, Pacini, Lorenza, De Feudis, Mauro, Cardelli, Valeria, Kicińska, Alicja, Stock, Michael J., Liu, Hongdou, Demiraj, Erdona, and Schillaci, Calogero
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- 2024
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38. Advancing tribological simulations of carbon-based lubricants with active learning and machine learning molecular dynamics
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Pacini, Alberto, Ferrario, Mauro, Loehle, Sophie, and Righi, M. Clelia
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- 2024
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39. Pluri-Potential Theory, Submersions and Calibrations
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Pacini, Tommaso
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- 2024
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40. Pluri-potential theory, submersions and calibrations
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Pacini, Tommaso
- Subjects
Mathematics - Differential Geometry ,Mathematics - Complex Variables - Abstract
We present a systematic collection of results concerning interactions between convex, subharmonic and pluri-subharmonic functions on pairs of manifolds related by a Riemannian submersion. Our results are modelled on those known in the classical complex-analytic context and represent another step in the recent Harvey-Lawson pluri-potential theory for calibrated manifolds. In particular we study the case of K\"ahler and G2 manifolds, emphasizing both parallels and differences. We show that previous results concerning Lagrangian fibrations can be viewed as an application of this framework., Comment: Revised version. To appear in the Journal of Geometric Analysis
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- 2022
41. Development of the photo-diode subsystem for the HERD calorimeter double-readout
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Adriani, O., Antonelli, M., Basti, A., Berti, E., Betti, P., Bigongiari, G., Bonechi, L., Bongi, M., Bonvicini, V., Bottai, S., Brogi, P., Castellini, G., Checchia, C., Casaus, J., Cui, X., Dong, Y., D'Alessandro, R., Detti, S., Giovacchini, F., Finetti, N., Maestro, P., Marrocchesi, P. S., Liu, X., Marin, J., Martinez, G., Mori, N., Pacini, L., Papini, P., Pizzolotto, C., Ricciarini, S., Spillantini, P., Starodubtsev, O., Stiaccini, L., Tang, Z., Tiberio, A., Vannuccini, E., Velasco, M., Wang, R., Wang, Z., Xu, M., Zampa, G., Zampa, N., and Zhang, L.
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Physics - Instrumentation and Detectors ,High Energy Physics - Experiment - Abstract
The measurement of cosmic-ray individual spectra provides unique information regarding the origin and propagation of astro-particles. Due to the limited acceptance of current space experiments, protons and nuclei around the "knee" region ($\sim1\ PeV$) can only be observed by ground based experiments. Thanks to an innovative design, the High Energy cosmic-Radiation Detection (HERD) facility will allow direct observation up to this energy region: the instrument is mainly based on a 3D segmented, isotropic and homogeneous calorimeter which properly measures the energy of particles coming from each direction and it will be made of about 7500 LYSO cubic crystals. The read-out of the scintillation light is done with two independent systems: the first one based on wave-length shifting fibers coupled to Intensified scientific CMOS cameras, the second one is made of two photo-diodes with different active areas connected to a custom front-end electronics. This photo-diode system is designed to achieve a huge dynamic range, larger than $10^7$, while having a small power consumption, few mW per channel. Thanks to a good signal-to-noise ratio, the capability of a proper calibration, by using signals of both non-interacting and showering particles, is also guaranteed. In this paper, the current design and the performance obtained by several tests of the photo-diode read-out system are discussed.
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- 2022
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42. Variation formulae for the volume of coassociative submanifolds
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Pacini, Tommaso and Raffero, Alberto
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Mathematics - Differential Geometry - Abstract
We prove new variation formulae for the volume of coassociative submanifolds, expressed in terms of $G_2$ data. As a special case, we obtain a second variation formula for variations within the moduli space of coassociative submanifolds; this formula highlights the role of the ambient torsion and Ricci curvature. These results apply, for example, to coassociative fibrations. We illustrate our formulae with several examples, both homogeneous and non., Comment: v.5: Minor changes. Final version, to appear in Annals of Global Analysis and Geometry
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- 2022
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43. Light yield non-proportionality of inorganic crystals and its effect on cosmic-ray measurements
- Author
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Adriani, O., Berti, E., Betti, P., Bigongiari, G., Bonechi, L., Bongi, M., Bottai, S., Brogi, P., Castellini, G., Checchia, C., Alessandro, R. D, Detti, S., Finetti, N., Maestro, P., Marrocchesi, P. S., Mori, N., Olmi, M., Pacini, L., Papini, P., Poggiali, C., Ricciarini, S., Spillantini, P., Starodubtsev, O., Stolzi, F., Tiberio, A., and Vannuccini, E.
- Subjects
Astrophysics - High Energy Astrophysical Phenomena ,Astrophysics - Instrumentation and Methods for Astrophysics ,High Energy Physics - Experiment - Abstract
The multi-TeV energy region of the cosmic-ray spectra has been recently explored by direct detection experiments that used calorimetric techniques to measure the energy of the cosmic particles. Interesting spectral features have been observed in both all-electron and nuclei spectra. However, the interpretation of the results is compromised by the disagreements between the data obtained from the various experiments, that are not reconcilable with the quoted experimental uncertainties. Understanding the reason for the discrepancy among the measurements is of fundamental importance in view of the forthcoming high-energy cosmic-ray experiments planned for space, as well as for the correct interpretation of the available results. The purpose of this work is to investigate the possibility that a systematic effect may derive from the non-proportionality of the light response of inorganic crystals, typically used in high-energy calorimetry due to their excellent energy-resolution performance. The main reason for the non-proportionality of the crystals is that scintillation light yield depends on ionisation density. Experimental data obtained with ion beams were used to characterize the light response of various scintillator materials. The obtained luminous efficiencies were used as input of a Monte Carlo simulation to perform a comparative study of the effect of the light-yield non-proportionality on the detection of high-energy electromagnetic and hadronic showers. The result of this study indicates that, if the calorimeter response is calibrated by using the energy deposit of minimum ionizing particles, the measured shower energy might be affected by a significant systematic shift, at the level of few percent, whose sign and magnitude depend specifically on the type of scintillator material used., Comment: to be published in JINST
- Published
- 2022
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44. CALET Search for electromagnetic counterparts of gravitational waves during the LIGO/Virgo O3 run
- Author
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Adriani, O., Akaike, Y., Asano, K., Asaoka, Y., Berti, E., Bigongiari, G., Binns, W. R., Bongi, M., Brogi, P., Bruno, A., Buckley, J. H., Cannady, N., Castellini, G., Checchia, C., Cherry, M. L., Collazuol, G., Ebisawa, K., Ficklin, A. W., Fuke, H., Gonzi, S., Guzik, T. G., Hams, T., Hibino, K., Ichimura, M., Ioka, K., Ishizaki, W., Israel, M. H., Kasahara, K., Kataoka, J., Kataoka, R., Katayose, Y., Kato, C., Kawanaka, N., Kawakubo, Y., Kobayashi, K., Kohri, K., Krawczynski, H. S., Krizmanic, J. F., Maestro, P., Marrocchesi, P. S., Messineo, A. M., Mitchell, J. W., Miyake, S., Moiseev, A. A., Mori, M., Mori, N., Motz, H. M., Munakata, K., Nakahira, S., Nishimura, J., de Nolfo, G. A., Okuno, S., Ormes, J. F., Ospina, N., Ozawa, S., Pacini, L., Papini, P., Rauch, B. F., Ricciarini, S. B., Sakai, K., Sakamoto, T., Sasaki, M., Shimizu, Y., Shiomi, A., Spillantini, P., Stolzi, F., Sugita, S., Sulaj, A., Takita, M., Tamura, T., Terasawa, T., Torii, S., Tsunesada, Y., Uchihori, Y., Vannuccini, E., Wefel, J. P., Yamaoka, K., Yanagita, S., Yoshida, A., Yoshida, K., and Zober, W. V.
- Subjects
Astrophysics - High Energy Astrophysical Phenomena - Abstract
The CALorimetric Electron Telescope (CALET) on the International Space Station (ISS) consists of a high-energy cosmic ray CALorimeter (CAL) and a lower-energy CALET Gamma ray Burst Monitor (CGBM). CAL is sensitive to electrons up to 20 TeV, cosmic ray nuclei from Z = 1 through Z $\sim$ 40, and gamma rays over the range 1 GeV - 10 TeV. CGBM observes gamma rays from 7 keV to 20 MeV. The combined CAL-CGBM instrument has conducted a search for gamma ray bursts (GRBs) since Oct. 2015. We report here on the results of a search for X-ray/gamma ray counterparts to gravitational wave events reported during the LIGO/Virgo observing run O3. No events have been detected that pass all acceptance criteria. We describe the components, performance, and triggering algorithms of the CGBM - the two Hard X-ray Monitors (HXM) consisting of LaBr$_{3}$(Ce) scintillators sensitive to 7 keV to 1 MeV gamma rays and a Soft Gamma ray Monitor (SGM) BGO scintillator sensitive to 40 keV to 20 MeV - and the high-energy CAL consisting of a CHarge-Detection module (CHD), IMaging Calorimeter (IMC), and fully active Total Absorption Calorimeter (TASC). The analysis procedure is described and upper limits to the time-averaged fluxes are presented., Comment: 27 pages, 10 figures. Accepted for publication in ApJ
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- 2022
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45. Inter-observer variability of expert-derived morphologic risk predictors in aortic dissection.
- Author
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Willemink, Martin, Mastrodicasa, Domenico, Codari, Marina, Chepelev, Leonid, Mistelbauer, Gabriel, Hanneman, Kate, Ouzounian, Maral, Ocazionez, Daniel, Afifi, Rana, Lacomis, Joan, Lovato, Luigi, Pacini, Davide, Folesani, Gianluca, Hinzpeter, Ricarda, Alkadhi, Hatem, Stillman, Arthur, Sailer, Anna, Turner, Valery, Hinostroza, Virginia, Bäumler, Kathrin, Chin, Anne, Burris, Nicholas, Miller, D, Fischbein, Michael, Fleischmann, Dominik, and Madani, Mohammad
- Subjects
Aortic dissection ,Computed tomography angiography ,Variability ,inter-observer ,Humans ,Observer Variation ,Reproducibility of Results ,Retrospective Studies ,Aortic Dissection ,Aorta - Abstract
OBJECTIVES: Establishing the reproducibility of expert-derived measurements on CTA exams of aortic dissection is clinically important and paramount for ground-truth determination for machine learning. METHODS: Four independent observers retrospectively evaluated CTA exams of 72 patients with uncomplicated Stanford type B aortic dissection and assessed the reproducibility of a recently proposed combination of four morphologic risk predictors (maximum aortic diameter, false lumen circumferential angle, false lumen outflow, and intercostal arteries). For the first inter-observer variability assessment, 47 CTA scans from one aortic center were evaluated by expert-observer 1 in an unconstrained clinical assessment without a standardized workflow and compared to a composite of three expert-observers (observers 2-4) using a standardized workflow. A second inter-observer variability assessment on 30 out of the 47 CTA scans compared observers 3 and 4 with a constrained, standardized workflow. A third inter-observer variability assessment was done after specialized training and tested between observers 3 and 4 in an external population of 25 CTA scans. Inter-observer agreement was assessed with intraclass correlation coefficients (ICCs) and Bland-Altman plots. RESULTS: Pre-training ICCs of the four morphologic features ranged from 0.04 (-0.05 to 0.13) to 0.68 (0.49-0.81) between observer 1 and observers 2-4 and from 0.50 (0.32-0.69) to 0.89 (0.78-0.95) between observers 3 and 4. ICCs improved after training ranging from 0.69 (0.52-0.87) to 0.97 (0.94-0.99), and Bland-Altman analysis showed decreased bias and limits of agreement. CONCLUSIONS: Manual morphologic feature measurements on CTA images can be optimized resulting in improved inter-observer reliability. This is essential for robust ground-truth determination for machine learning models. KEY POINTS: • Clinical fashion manual measurements of aortic CTA imaging features showed poor inter-observer reproducibility. • A standardized workflow with standardized training resulted in substantial improvements with excellent inter-observer reproducibility. • Robust ground truth labels obtained manually with excellent inter-observer reproducibility are key to develop reliable machine learning models.
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- 2023
46. The moduli space of quasistable spin curves
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Abreu, Alex, Pacini, Marco, and Taboada, Danny
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- 2024
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47. On moduli spaces of roots in algebraic and tropical geometry
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Abreu, Alex, Pacini, Marco, and Secco, Matheus
- Subjects
Mathematics - Algebraic Geometry - Abstract
In this paper we construct a tropical moduli space parametrizing roots of divisors on tropical curves. We study the relation between this space and the skeleton of Jarvis moduli space of nets of limit roots on stable curves. We show that the combinatorics of the moduli space of tropical roots is governed by the poset of flows, a poset parametrizing certain flows on graphs., Comment: 23 pages
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- 2022
48. Direct Measurement of the Nickel Spectrum in Cosmic Rays in the Energy Range from 8.8 GeV/n to 240 GeV/n with CALET on the International Space Station
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Adriani, O., Akaike, Y., Asano, K., Asaoka, Y., Berti, E., Bigongiari, G., Binns, W. R., Bongi, M., Brogi, P., Bruno, A., Buckley, J. H., Cannady, N., Castellini, G., Checchia, C., Cherry, M. L., Collazuol, G., Ebisawa, K., Ficklin, A. W., Fuke, H., Gonzi, S., Guzik, T. G., Hams, T., Hibino, K., Ichimura, M., Ioka, K., Ishizaki, W., Israel, M. H., Kasahara, K., Kataoka, J., Kataoka, R., Katayose, Y., Kato, C., Kawanaka, N., Kawakubo, Y., Kobayashi, K., Kohri, K., Krawczynski, H. S., Krizmanic, J. F., Maestro, P., Marrocchesi, P. S., Messineo, A. M., Mitchell, J. W., Miyake, S., Moiseev, A. A., Mori, M., Mori, N., Motz, H. M., Munakata, K., Nakahira, S., Nishimura, J., de Nolfo, G. A., Okuno, S., Ormes, J. F., Ospina, N., Ozawa, S., Pacini, L., Papini, P., Rauch, B. F., Ricciarini, S. B., Sakai, K., Sakamoto, T., Sasaki, M., Shimizu, Y., Shiomi, A., Spillantini, P., Stolzi, F., Sugita, S., Sulaj, A., Takita, M., Tamura, T., Terasawa, T., Torii, S., Tsunesada, Y., Uchihori, Y., Vannuccini, E., Wefel, J. P., Yamaoka, K., Yanagita, S., Yoshida, A., Yoshida, K., and Zober, W. V.
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Astrophysics - High Energy Astrophysical Phenomena - Abstract
The relative abundance of cosmic ray nickel nuclei with respect to iron is by far larger than for all other trans-iron elements, therefore it provides a favorable opportunity for a low background measurement of its spectrum. Since nickel, as well as iron, is one of the most stable nuclei, the nickel energy spectrum and its relative abundance with respect to iron provide important information to estimate the abundances at the cosmic ray source and to model the Galactic propagation of heavy nuclei. However, only a few direct measurements of cosmic-ray nickel at energy larger than $ \sim$ 3 GeV/n are available at present in the literature and they are affected by strong limitations in both energy reach and statistics. In this paper we present a measurement of the differential energy spectrum of nickel in the energy range from 8.8 to 240 GeV/n, carried out with unprecedented precision by the Calorimetric Electron Telescope (CALET) in operation on the International Space Station since 2015. The CALET instrument can identify individual nuclear species via a measurement of their electric charge with a dynamic range extending far beyond iron (up to atomic number $ Z $ = 40). The particle's energy is measured by a homogeneous calorimeter (1.2 proton interaction lengths, 27 radiation lengths) preceded by a thin imaging section (3 radiation lengths) providing tracking and energy sampling. This paper follows our previous measurement of the iron spectrum [O. Adriani et al., Phys. Rev. Lett. 126, 241101 (2021).], and it extends our investigation on the energy dependence of the spectral index of heavy elements. It reports the analysis of nickel data collected from November 2015 to May 2021 and a detailed assessment of the systematic uncertainties. In the region from 20 to 240 GeV$ /n $ our present data are compatible within the errors with a single power law with spectral index $ -2.51 \pm 0.07 $., Comment: main text: 8 pages, 4 figures; supplemental material: 8 pages, 9 figures, 1 table. arXiv admin note: text overlap with arXiv:2106.08036
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- 2022
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49. Frozen elephant trunk in acute aortic dissection: a literature review
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Murana, Giacomo, Campanini, Francesco, Orioli, Valentina, Pagano, Vinvenzo, Santamaria, Valeria, Di Marco, Luca, Di Bartolomeo, Roberto, and Pacini, Davide
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- 2023
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50. Staging TEVAR after FET — an exception or the rule?
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Di Marco, Luca, Nocera, Chiara, Snaidero, Silvia, Campanini, Francesco, Buia, Francesco, Lovato, Luigi, Murana, Giacomo, and Pacini, Davide
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- 2023
- Full Text
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