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1. Developments and results in the context of the JEM-EUSO program obtained with the ESAF simulation and analysis framework

Author

S. Abe, J. H. Adams, D. Allard, P. Alldredge, L. Anchordoqui, A. Anzalone, E. Arnone, B. Baret, D. Barghini, M. Battisti, J. Bayer, R. Bellotti, A. A. Belov, M. Bertaina, P. F. Bertone, M. Bianciotto, P. L. Biermann, F. Bisconti, C. Blaksley, S. Blin-Bondil, P. Bobik, K. Bolmgren, S. Briz, J. Burton, F. Cafagna, G. Cambié, D. Campana, F. Capel, R. Caruso, M. Casolino, C. Cassardo, A. Castellina, K. Černý, M. J. Christl, R. Colalillo, L. Conti, G. Cotto, H. J. Crawford, R. Cremonini, A. Creusot, A. Cummings, A. de Castro Gónzalez, C. de la Taille, L. del Peral, R. Diesing, P. Dinaucourt, A. Di Nola, A. Ebersoldt, T. Ebisuzaki, J. Eser, F. Fenu, S. Ferrarese, G. Filippatos, W. W. Finch, F. Flaminio, C. Fornaro, D. Fuehne, C. Fuglesang, M. Fukushima, D. Gardiol, G. K. Garipov, A. Golzio, P. Gorodetzky, F. Guarino, C. Guépin, A. Guzmán, A. Haungs, T. Heibges, J. Hernández-Carretero, F. Isgrò, E. G. Judd, F. Kajino, I. Kaneko, Y. Kawasaki, M. Kleifges, P. A. Klimov, I. Kreykenbohm, J. F. Krizmanic, V. Kungel, E. Kuznetsov, F. López Martínez, S. Mackovjak, D. Mandát, M. Manfrin, A. Marcelli, L. Marcelli, W. Marszał, J. N. Matthews, A. Menshikov, T. Mernik, M. Mese, S. S. Meyer, J. Mimouni, H. Miyamoto, Y. Mizumoto, A. Monaco, J.A Morales de los Ríos, S. Nagataki, J. M. Nachtman, D. Naumov, A. Neronov, T. Nonaka, T. Ogawa, S. Ogio, H. Ohmori, A. V. Olinto, Y. Onel, G. Osteria, A. Pagliaro, B. Panico, E. Parizot, I. H. Park, B. Pastircak, T. Paul, M. Pech, F. Perfetto, P. Picozza, L. W. Piotrowski, Z. Plebaniak, J. Posligua, R. Prevete, G. Prévôt, H. Prieto, M. Przybylak, M. Putis, E. Reali, P. Reardon, M. H. Reno, M. Ricci, M. Rodríguez Frías, G. Romoli, G. Sáez Cano, H. Sagawa, N. Sakaki, A. Santangelo, O. A. Saprykin, F. Sarazin, M. Sato, H. Schieler, P. Schovánek, V. Scotti, S. Selmane, S. A. Sharakin, K. Shinozaki, J. F. Soriano, J. Szabelski, N. Tajima, T. Tajima, Y. Takahashi, M. Takeda, Y. Takizawa, C. Tenzer, S. B. Thomas, L. G. Tkachev, T. Tomida, S. Toscano, M. Traïche, D. Trofimov, K. Tsuno, P. Vallania, L. Valore, T. M. Venters, C. Vigorito, P. von Ballmoos, M. Vrabel, S. Wada, J. Watts, A. Weindl, L. Wiencke, J. Wilms, D. Winn, H. Wistrand, I. V. Yashin, R. Young, and M. Yu. Zotov

Subjects
Astrophysics, QB460-466, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

Abstract JEM-EUSO is an international program for the development of space-based Ultra-High Energy Cosmic Ray observatories. The program consists of a series of missions which are either under development or in the data analysis phase. All instruments are based on a wide-field-of-view telescope, which operates in the near-UV range, designed to detect the fluorescence light emitted by extensive air showers in the atmosphere. We describe the simulation software ESAF in the framework of the JEM-EUSO program and explain the physical assumptions used. We present here the implementation of the JEM-EUSO, POEMMA, K-EUSO, TUS, Mini-EUSO, EUSO-SPB1 and EUSO-TA configurations in ESAF. For the first time ESAF simulation outputs are compared with experimental data.

Published
2023
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2. EUSO-SPB1 Mission and Science

Author

Collaboration, JEM-EUSO, Abdellaoui, G., Abe, S., Adams. Jr., J. H., Allard, D., Alonso, G., Anchordoqui, L., Anzalone, A., Arnone, E., Asano, K., Attallah, R., Attoui, H., Pernas, M. Ave, Bachmann, R., Bacholle, S., Bagheri, M., Bakiri, M., Baláz, J., Barghini, D., Bartocci, S., Battisti, M., Bayer, J., Beldjilali, B., Belenguer, T., Belkhalfa, N., Bellotti, R., Belov, A. A., Benmessai, K., Bertaina, M., Bertone, P. F., Biermann, P. L., Bisconti, F., Blaksley, C., Blanc, N., Blin-Bondil, S., Bobik, P., Bogomilov, M., Bolmgren, K., Bozzo, E., Briz, S., Bruno, A., Caballero, K. S., Cafagna, F., Cambié, G., Campana, D., Capdevielle, J. N., Capel, F., Caramete, A., Caramete, L., Caruso, R., Casolino, M., Cassardo, C., Castellina, A., Catalano, O., Cellino, A., Černý, K., Chikawa, M., Chiritoi, G., Christl, M. J., Colalillo, R., Conti, L., Cotto, G., Crawford, H. J., Cremonini, R., Creusot, A., Cummings, A., Gónzalez, A. de Castro, de la Taille, C., del Peral, L., Desiato, J., Damian, A. Diaz, Diesing, R., Dinaucourt, P., Djakonow, A., Djemil, T., Ebersoldt, A., Ebisuzaki, T., Eser, J., Fenu, F., Fernández-González, S., Ferrarese, S., Filippatos, G., Finch, W., Fornaro, C., Fouka, M., Franceschi, A., Franchini, S., Fuglesang, C., Fujii, T., Fukushima, M., Galeotti, P., García-Ortega, E., Gardiol, D., Garipov, G. K., Gascón, E., Gazda, E., Genci, J., Golzio, A., Gorodetzky, P., Gregg, R., Green, A., Guarino, F., Guépin, C., Guzmán, A., Hachisu, Y., Haungs, A., Heigbes, T., Carretero, J. Hernández, Hulett, L., Ikeda, D., Inoue, N., Inoue, S., Isgrò, F., Itow, Y., Jammer, T., Jeong, S., Jochum, J., Joven, E., Judd, E. G., Jung, A., Kajino, F., Kajino, T., Kalli, S., Kaneko, I., Kasztelan, M., Katahira, K., Kawai, K., Kawasaki, Y., Kedadra, A., Khales, H., Khrenov, B. A., Kim, Jeong-Sook, Kim, Soon-Wook, Kleifges, M., Klimov, P. A., Kreykenbohm, I., Krizmanic, J. F., Królik, K., Kungel, V., Kurihara, Y., Kusenko, A., Kuznetsov, E., Lahmar, H., Lakhdari, F., Licandro, J., Campano, L. López, Martínez, F. López, Mackovjak, S., Mahdi, M., Mandát, D., Manfrin, M., Marcelli, L., Marcos, J. L., Marszał, W., Martín, Y., Martinez, O., Mase, K., Mastafa, M., Matthews, J. N., Mebarki, N., Medina-Tanco, G., Menshikov, A., Merino, A., Mese, M., Meseguer, J., Meyer, S. S., Mimouni, J., Miyamoto, H., Mizumoto, Y., Monaco, A., Ríos, J. A. Morales de los, Nachtman, J. M., Nagataki, S., Naitamor, S., Napolitano, T., Neronov, A., Nomoto, K., Nonaka, T., Ogawa, T., Ogio, S., Ohmori, H., Olinto, A. V., Onel, Y., Osteria, G., Otte, A. N., Pagliaro, A., Painter, W., Panasyuk, M. I., Panico, B., Parizot, E., Park, I. H., Pastircak, B., Paul, T., Pech, M., Pérez-Grande, I., Perfetto, F., Peter, T., Picozza, P., Pindado, S., Piotrowski, L. W., Piraino, S., Plebaniak, Z., Pollini, A., Popescu, E. M., Prevete, R., Prévôt, G., Prieto, H., Przybylak, M., Puehlhofer, G., Putis, M., Reardon, P., Reno, M. H., Reyes, M., Ricci, M., Frías, M. D. Rodríguez, Matamala, O. F. Romero, Ronga, F., Sabau, M. D., Saccá, G., Sagawa, H., Sahnoune, Z., Saito, A., Sakaki, N., Salazar, H., Sánchez, J. L., Balanzar, J. C. Sanchez, Santangelo, A., Sanz-Andrés, A., Saprykin, O. A., Sarazin, F., Sato, M., Scagliola, A., Schanz, T., Schieler, H., Schovánek, P., Scotti, V., Serra, M., Sharakin, S. A., Shimizu, H. M., Shinozaki, K., Soriano, J. F., Sotgiu, A., Stan, I., Strharský, I., Sugiyama, N., Supanitsky, D., Suzuki, M., Szabelski, J., Tajima, N., Tajima, T., Takahashi, Y., Takeda, M., Takizawa, Y., Talai, M. C., Tameda, Y., Tenzer, C., Thomas, S. B., Tibolla, O., Tkachev, L. G., Tomida, T., Tone, N., Toscano, S., Traïche, M., Tsunesada, Y., Tsuno, K., Turriziani, S., Uchihori, Y., Valdés-Galicia, J. F., Vallania, P., Valore, L., Vankova-Kirilova, G., Venters, T. M., Vigorito, C., Villaseñor, L., Vlcek, B., von Ballmoos, P., Vrabel, M., Wada, S., Watanabe, J., Watts. Jr., J., Muñoz, R. Weigand, Weindl, A., Wiencke, L., Wille, M., Wilms, J., Yamamoto, T., Yang, J., Yano, H., Yashin, I. V., Yonetoku, D., Yoshida, S., Young, R., Zgura, I. S., Zotov, M. Yu., and Marchi, A. Zuccaro

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - High Energy Astrophysical Phenomena
Abstract

The Extreme Universe Space Observatory on a Super Pressure Balloon 1 (EUSO-SPB1) was launched in 2017 April from Wanaka, New Zealand. The plan of this mission of opportunity on a NASA super pressure balloon test flight was to circle the southern hemisphere. The primary scientific goal was to make the first observations of ultra-high-energy cosmic-ray extensive air showers (EASs) by looking down on the atmosphere with an ultraviolet (UV) fluorescence telescope from suborbital altitude (33~km). After 12~days and 4~hours aloft, the flight was terminated prematurely in the Pacific Ocean. Before the flight, the instrument was tested extensively in the West Desert of Utah, USA, with UV point sources and lasers. The test results indicated that the instrument had sensitivity to EASs of approximately 3 EeV. Simulations of the telescope system, telescope on time, and realized flight trajectory predicted an observation of about 1 event assuming clear sky conditions. The effects of high clouds were estimated to reduce this value by approximately a factor of 2. A manual search and a machine-learning-based search did not find any EAS signals in these data. Here we review the EUSO-SPB1 instrument and flight and the EAS search., Comment: 18 pages, 19 figures

Published
2024
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3. Developments and results in the context of the JEM-EUSO program obtained with the ESAF Simulation and Analysis Framework

Author

Abe, S., Adams Jr., J. H., Allard, D., Alldredge, P., Anchordoqui, L., Anzalone, A., Arnone, E., Baret, B., Barghini, D., Battisti, M., Bayer, J., Bellotti, R., Belov, A. A., Bertaina, M., Bertone, P. F., Bianciotto, M., Biermann, P. L., Bisconti, F., Blaksley, C., Blin-Bondil, S., Bobik, P., Bolmgren, K., Briz, S., Burton, J., Cafagna, F., Cambié, G., Campana, D., Capel, F., Caruso, R., Casolino, M., Cassardo, C., Castellina, A., Černý, K., Christl, M. J., Colalillo, R., Conti, L., Cotto, G., Crawford, H. J., Cremonini, R., Creusot, A., Cummings, A., Gónzalez, A. de Castro, de la Taille, C., del Peral, L., Diesing, R., Dinaucourt, P., Di Nola, A., Ebersoldt, A., Ebisuzaki, T., Eser, J., Fenu, F., Ferrarese, S., Filippatos, G., Finch, W. W., Flaminio, F., Fornaro, C., Fuehne, D., Fuglesang, C., Fukushima, M., Gardiol, D., Garipov, G. K., Golzio, A., Gorodetzky, P., Guarino, F., Guépin, C., Guzmán, A., Haungs, A., Heibges, T., Hernández-Carretero, J., Isgrò, F., Judd, E. G., Kajino, F., Kaneko, I., Kawasaki, Y., Kleifges, M., Klimov, P. A., Kreykenbohm, I., Krizmanic, J. F., Kungel, V., Kuznetsov, E., Martínez, F. López, Mackovjak, S., Mandát, D., Manfrin, M., Marcelli, A., Marcelli, L., Marszał, W., Matthews, J. N., Menshikov, A., Mernik, T., Mese, M., Meyer, S. S., Mimouni, J., Miyamoto, H., Mizumoto, Y., Monaco, A., Ríos, J. A Morales de los, Nagataki, S., Nachtman, J. M., Naumov, D., Neronov, A., Nonaka, T., Ogawa, T., Ogio, S., Ohmori, H., Olinto, A. V., Onel, Y., Osteria, G., Pagliaro, A., Panico, B., Parizot, E., Park, I. H., Pastircak, B., Paul, T., Pech, M., Perfetto, F., Picozza, P., Piotrowski, L. W., Plebaniak, Z., Posligua, J., Prevete, R., Prévôt, G., Prieto, H., Przybylak, M., Putis, M., Reali, E., Reardon, P., Reno, M. H., Ricci, M., Frías, M. Rodríguez, Romoli, G., Cano, G. Sáez, Sagawa, H., Sakaki, N., Santangelo, A., Saprykin, O. A., Sarazin, F., Sato, M., Schieler, H., Schovánek, P., Scotti, V., Selmane, S., Sharakin, S. A., Shinozaki, K., Soriano, J. F., Szabelski, J., Tajima, N., Tajima, T., Takahashi, Y., Takeda, M., Takizawa, Y., Tenzer, C., Thomas, S. B., Tkachev, L. G., Tomida, T., Toscano, S., Traïche, M., Trofimov, D., Tsuno, K., Vallania, P., Valore, L., Venters, T. M., Vigorito, C., von Ballmoos, P., Vrabel, M., Wada, S., Watts Jr., J., Weindl, A., Wiencke, L., Wilms, J., Winn, D., Wistrand, H., Yashin, I. V., Young, R., and Zotov, M. Yu.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, High Energy Physics - Experiment
Abstract

JEM--EUSO is an international program for the development of space-based Ultra-High Energy Cosmic Ray observatories. The program consists of a series of missions which are either under development or in the data analysis phase. All instruments are based on a wide-field-of-view telescope, which operates in the near-UV range, designed to detect the fluorescence light emitted by extensive air showers in the atmosphere. We describe the simulation software ESAFin the framework of the JEM--EUSO program and explain the physical assumptions used. We present here the implementation of the JEM--EUSO, POEMMA, K--EUSO, TUS, Mini--EUSO, EUSO--SPB1 and EUSO--TA configurations in ESAF. For the first time ESAF simulation outputs are compared with experimental data.

Published
2023
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4. Two-dimensional high-throughput on-cell screening of immunoglobulins against broad antigen repertoires

Author

Lomakin, Yakov A., Ovchinnikova, Leyla A., Terekhov, Stanislav S., Dzhelad, Samir S., Yaroshevich, Igor, Mamedov, Ilgar, Smirnova, Anastasia, Grigoreva, Tatiana, Eliseev, Igor E., Filimonova, Ioanna N., Mokrushina, Yuliana A., Abrikosova, Victoria, Rubtsova, Maria P., Kostin, Nikita N., Simonova, Maria A., Bobik, Tatiana V., Aleshenko, Natalia L., Alekhin, Alexander I., Boitsov, Vitali M., Zhang, Hongkai, Smirnov, Ivan V., Rubtsov, Yuri P., and Gabibov, Alexander G.

Published
2024
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6. JEM-EUSO Collaboration contributions to the 37th International Cosmic Ray Conference

Author

Abdellaoui, G., Abe, S., Adams Jr., J. H., Allard, D., Alonso, G., Anchordoqui, L., Anzalone, A., Arnone, E., Asano, K., Attallah, R., Attoui, H., Pernas, M. Ave, Bagheri, M., Baláz, J., Bakiri, M., Barghini, D., Bartocci, S., Battisti, M., Bayer, J., Beldjilali, B., Belenguer, T., Belkhalfa, N., Bellotti, R., Belov, A. A., Benmessai, K., Bertaina, M., Bertone, P. F., Biermann, P. L., Bisconti, F., Blaksley, C., Blanc, N., Blin-Bondil, S., Bobik, P., Bogomilov, M., Bolmgren, K., Bozzo, E., Briz, S., Bruno, A., Caballero, K. S., Cafagna, F., Cambié, G., Campana, D., Capdevielle, J-N., Capel, F., Caramete, A., Caramete, L., Carlson, P., Caruso, R., Casolino, M., Cassardo, C., Castellina, A., Catalano, O., Cellino, A., Černý, K., Chikawa, M., Chiritoi, G., Christl, M. J., Colalillo, R., Conti, L., Cotto, G., Crawford, H. J., Cremonini, R., Creusot, A., Gónzalez, A. de Castro, de la Taille, C., del Peral, L., Damian, A. Diaz, Diesing, R., Dinaucourt, P., Djakonow, A., Djemil, T., Ebersoldt, A., Ebisuzaki, T., Eser, J., Fenu, F., Fernández-González, S., Ferrarese, S., Filippatos, G., Fornaro, W. I. Finch C., Fouka, M., Franceschi, A., Franchini, S., Fuglesang, C., Fujii, T., Fukushima, M., Galeotti, P., García-Ortega, E., Gardiol, D., Garipov, G. K., Gascón, E., Gazda, E., Genci, J., Golzio, A., Alvarado, C. González, Gorodetzky, P., Green, A., Guarino, F., Guépin, C., Guzmán, A., Hachisu, Y., Haungs, A., Carretero, J. Hernández, Hulett, L., Ikeda, D., Inoue, N., Inoue, S., Isgrò, F., Itow, Y., Jammer, T., Jeong, S., Joven, E., Judd, E. G., Jochum, J., Kajino, F., Kajino, T., Kalli, S., Kaneko, I., Karadzhov, Y., Kasztelan, M., Katahira, K., Kawai, K., Kawasaki, Y., Kedadra, A., Khales, H., Khrenov, B. A., Kim, Jeong-Sook, Kim, Soon-Wook, Kleifges, M., Klimov, P. A., Kolev, D., Kreykenbohm, I., Krizmanic, J. F., Królik, K., Kungel, V., Kurihara, Y., Kusenko, A., Kuznetsov, E., Lahmar, H., Lakhdari, F., Licandro, J., Campano, L. López, Martínez, F. López, Mackovjak, S., Mahdi, M., Mandát, D., Manfrin, M., Marcelli, L., Marcos, J. L., Marszał, W., Martín, Y., Martinez, O., Mase, K., Matev, R., Matthews, J. N., Mebarki, N., Medina-Tanco, G., Menshikov, A., Merino, A., Mese, M., Meseguer, J., Meyer, S. S., Mimouni, J., Miyamoto, H., Mizumoto, Y., Monaco, A., Ríos, J. A. Morales de los, Mastafa, M., Nagataki, S., Naitamor, S., Napolitano, T., Neronov, J. M. Nachtman A., Nomoto, K., Nonaka, T., Ogawa, T., Ogio, S., Ohmori, H., Olinto, A. V., Osteria, Y. Onel G., Otte, A. N., Pagliaro, A., Painter, W., Panasyuk, M. I., Panico, B., Parizot, E., Park, I. H., Pastircak, B., Paul, T., Pech, M., Pérez-Grande, I., Perfetto, F., Peter, T., Picozza, P., Pindado, S., Piotrowski, L. W., Piraino, S., Plebaniak, Z., Pollini, A., Popescu, E. M., Prevete, R., Prévôt, G., Prieto, H., Przybylak, M., Puehlhofer, G., Putis, M., Reardon, P., Reno, M. H., Reyes, M., Ricci, M., Frías, M. D. Rodríguez, Matamala, O. F. Romero, Ronga, F., Sabau, M. D., Saccá, G., Cano, G. Sáez, Sagawa, H., Sahnoune, Z., Saito, A., Sakaki, N., Salazar, H., Balanzar, J. C. Sanchez, Sánchez, J. L., Santangelo, A., Sanz-Andrés, A., Palomino, M. Sanz, Saprykin, O. A., Sarazin, F., Sato, M., Scagliola, A., Schanz, T., Schieler, H., Schovánek, P., Scotti, V., Serra, M., Sharakin, S. A., Shimizu, H. M., Shinozaki, K., Soriano, J. F., Sotgiu, A., Stan, I., Strharský, I., Sugiyama, N., Supanitsky, D., Suzuki, M., Szabelski, J., Tajima, N., Tajima, T., Takahashi, Y., Takeda, M., Takizawa, Y., Talai, M. C., Tameda, Y., Tenzer, C., Thomas, S. B., Tibolla, O., Tkachev, L. G., Tomida, T., Tone, N., Toscano, S., Traïche, M., Tsunesada, Y., Tsuno, K., Turriziani, S., Uchihori, Y., Vaduvescu, O., Valdés-Galicia, J. F., Vallania, P., Valore, L., Vankova-Kirilova, G., Venters, T. M., Vigorito, C., Villaseñor, L., Vlcek, B., von Ballmoos, P., Vrabel, M., Wada, S., Watanabe, J., Watts Jr., J., Muñoz, R. Weigand, Weindl, A., Wiencke, L., Wille, M., Wilms, J., Yamamoto, D. Winn T., Yang, J., Yano, H., Yashin, I. V., Yonetoku, D., Yoshida, S., Young, R., Zgura, I. S., Zotov, M. Yu., and Marchi, A. Zuccaro

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

Compilation of papers presented by the JEM-EUSO Collaboration at the 37th International Cosmic Ray Conference (ICRC), held on July 12-23, 2021 (online) in Berlin, Germany., Comment: html page with links to the JEM-EUSO Collaboration papers presented at ICRC-2021, Berlin, Germany

Published
2022

7. Latitudinal Dependence of Cosmic Rays Modulation at 1 AU and Interplanetary Magnetic Field Polar Correction

Author

P. Bobik, G. Boella, M. J. Boschini, C. Consolandi, S. Della Torre, M. Gervasi, D. Grandi, K. Kudela, S. Pensotti, P. G. Rancoita, D. Rozza, and M. Tacconi

Subjects
Astronomy, QB1-991
Abstract

The cosmic rays differential intensity inside the heliosphere, for energy below 30 GeV/nuc, depends on solar activity and interplanetary magnetic field polarity. This variation, termed solar modulation, is described using a 2D (radius and colatitude) Monte Carlo approach for solving the Parker transport equation that includes diffusion, convection, magnetic drift, and adiabatic energy loss. Since the whole transport is strongly related to the interplanetary magnetic field (IMF) structure, a better understanding of his description is needed in order to reproduce the cosmic rays intensity at the Earth, as well as outside the ecliptic plane. In this work an interplanetary magnetic field model including the standard description on ecliptic region and a polar correction is presented. This treatment of the IMF, implemented in the HelMod Monte Carlo code (version 2.0), was used to determine the effects on the differential intensity of Proton at 1 AU and allowed one to investigate how latitudinal gradients of proton intensities, observed in the inner heliosphere with the Ulysses spacecraft during 1995, can be affected by the modification of the IMF in the polar regions.

Published
2013
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10. Contributions to the 36th International Cosmic Ray Conference (ICRC 2019) of the JEM-EUSO Collaboration

Author

Abdellaoui, G., Abe, S., Adams Jr., J. H., Ahriche, A., Allard, D., Allen, L., Alonso, G., Anchordoqui, L., Anzalone, A., Arai, Y., Asano, K., Attallah, R., Attoui, H., Pernas, M. Ave, Bacholle, S., Bakiri, M., Baragatti, P., Barrillon, P., Bartocci, S., Bayer, J., Beldjilali, B., Belenguer, T., Belkhalfa, N., Bellotti, R., Belov, A., Belov, K., Benmessai, K., Bertaina, M., Biermann, P. L., Biktemerova, S., Bisconti, F., Blaksley, C., Blanc, N., Błęcki, J., Blin-Bondil, S., Bobik, P., Bogomilov, M., Bozzo, E., Pacheco, S. Briz, Bruno, A., Caballero, K. S., Cafagna, F., Campana, D., Capdevielle, J-N., Capel, F., Caramete, A., Caramete, L., Carlson, P., Caruso, R., Casolino, M., Cassardo, C., Castellina, A., Catalano, O., Cellino, A., Chikawa, M., Chiritoi, G., Christl, M. J., Connaughton, V., Conti, L., Cotto, G., Crawford, H. J., Cremonini, R., Creusot, A., Csorna, S., Cummings, A., Dagoret-Campagne, S., Gónzalez, A. de Castro, De Donato, C., de la Taille, C., De Santis, C., del Peral, L., Di Martino, M., Damian, A. Diaz, Djemil, T., Dutan, I., Ebersoldt, A., Ebisuzaki, T., Engel, R., Eser, J., Fenu, F., Fernández-González, S., Ferrarese, S., Flamini, M., Fornaro, C., Fouka, M., Franceschi, A., Franchini, S., Fuglesang, C., Fujii, T., Fujimoto, J., Fukushima, M., Galeotti, P., García-Ortega, E., Garipov, G., Gascón, E., Genci, J., Giraudo, G., Alvarado, C. González, Gorodetzky, P., Greg, R., Guarino, F., Guzmán, A., Hachisu, Y., Haiduc, M., Harlov, B., Haungs, A., Carretero, J. Hernández, Cruz, W. Hidber, Ikeda, D., Inoue, N., Inoue, S., Isgrò, F., Itow, Y., Jammer, T., Jeong, S., Joven, E., Judd, E. G., Jung, A., Jochum, J., Kajino, F., Kajino, T., Kalli, S., Kaneko, I., Karadzhov, Y., Karczmarczyk, J., Katahira, K., Kawai, K., Kawasaki, Y., Kedadra, A., Khales, H., Khrenov, B. A., Kim, Jeong-Sook, Kim, Soon-Wook, Kleifges, M., Klimov, P. A., Kolev, D., Krantz, H., Kreykenbohm, I., Krizmanic, J. F., Kudela, K., Kurihara, Y., Kusenko, A., Kuznetsov, E., La Barbera, A., Lahmar, H., Lakhdari, F., Larsson, O., Lee, J., Licandro, J., Campano, L. López, Martínez, F. López, Maccarone, M. C., Mackovjak, S., Mahdi, M., Maravilla, D., Marcelli, L., Marcos, J. L., Marini, A., Marszał, W., Martens, K., Martín, Y., Martinez, O., Martucci, M., Masciantonio, G., Mase, K., Matev, R., Matthews, J. N., Mebarki, N., Medina-Tanco, G., Menshikov, A., Merino, A., Meseguer, J., Meyer, S. S., Mimouni, J., Miyamoto, H., Mizumoto, Y., Monaco, A., Ríos, J. A. Morales de los, Mustafa, M., Nagataki, S., Naitamor, S., Napolitano, T., Nava, R., Neronov, A., Nomoto, K., Nonaka, T., Ogawa, T., Ogio, S., Ohmori, H., Olinto, A. V., Orleaánski, P., Osteria, G., Pagliaro, A., Painter, W., Panasyuk, M. I., Panico, B., Parizot, E., Park, I. H., Pastircak, B., Patzak, T., Paul, T., Pérez-Grande, I., Perfetto, F., Peter, T., Picozza, P., Pindado, S., Piotrowski, L. W., Piraino, S., Placidi, L., Plebaniak, Z., Pliego, S., Pollini, A., Polonski, Z., Popescu, E. M., Prat, P., Prévôt, G., Prieto, H., Puehlhofer, G., Putis, M., Rabanal, J., Radu, A. A., Reyes, M., Rezazadeh, M., Ricci, M., Frías, M. D. Rodríguez, Ronga, F., Roudil, G., Rusinov, I., Rybczyński, M., Sabau, M. D., Cano, G. Sáaez, Sagawa, H., Sahnoune, Z., Saito, A., Sakaki, N., Salazar, H., Balanzar, J. C. Sanchez, Sánchez, J. L., Santangelo, A., Sanz-Andrés, A., Palomino, M. Sanz, Saprykin, O., Sarazin, F., Sato, M., Schanz, T., Schieler, H., Scotti, V., Selmane, S., Semikoz, D., Serra, M., Sharakin, S., Shimizu, H. M., Shinozaki, K., Shirahama, T., Spataro, B., Stan, I., Sugiyama, T., Supanitsky, D., Suzuki, M., Szabelska, B., Szabelski, J., Tajima, N., Tajima, T., Takahashi, Y., Takami, H., Takeda, M., Takizawa, Y., Talai, M. C., Tenzer, C., Thomas, S. B., Tibolla, O., Tkachev, L., Tokuno, H., Tomida, T., Tone, N., Toscano, S., Traïche, M., Tsenov, R., Tsunesada, Y., Tsuno, K., Tubbs, J., Turriziani, S., Uchihori, Y., Vaduvescu, O., Valdés-Galicia, J. F., Vallania, P., Vankova, G., Vigorito, C., Villaseñor, L., Vlcek, B., von Ballmoos, P., Vrabel, M., Wada, S., Watanabe, J., Watts Jr., J., Weber, M., Muñoz, R. Weigand, Weindl, A., Wiencke, L., Wille, M., Wilms, J., Włodarczyk, Z., Yamamoto, T., Yang, J., Yano, H., Yashin, I. V., Yonetoku, D., Yoshida, S., Young, R., Zgura, I. S, Zotov, M. Yu., and Marchi, A. Zuccaro

Subjects
Astrophysics - High Energy Astrophysical Phenomena
Abstract

Compilation of papers presented by the JEM-EUSO Collaboration at the 36th International Cosmic Ray Conference (ICRC), held July 24 through August 1, 2019 in Madison, Wisconsin., Comment: links to the 24 papers published in arXiv

Published
2019

11. Machine Learning Approach for Air Shower Recognition in EUSO-SPB Data

Author

Vrábel, Michal, Genči, Ján, Bobik, Pavol, and Bisconti, Francesca

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, Computer Science - Machine Learning
Abstract

The main goal of The Extreme Universe Space Observatory on a Super Pressure Balloon (EUSO-SPB1) was to observe from above extensive air showers caused by ultra-high energy cosmic rays. EUSO-SPB1 uses a fluorescence detector that observes the atmosphere in a nadir observation mode from a near space altitude. During the 12-day flight, an onboard first level trigger detected more than \num{175000} candidate events. This paper presents an approach to recognize air showers in this dataset. The approach uses a feature extraction method to create a simpler representation of an event and then it uses established machine learning techniques to classify data into at least two classes - shower and noise. The machine learning models are trained on a set of air shower simulations put on top of the background observed during the flight and a set of events from the flight. We present the efficiency of the method on datasets of simulated events. The flight data events are also used in unsupervised learning methods to identify groups of events with similar features. The presented methods allow us to shorten the candidate events list and, thanks to the groups of similar events identified by the unsupervised methods, the classification of the triggered events is made simpler., Comment: 8 pages, 8 figures, ICRC2019

Published
2019

12. The Environmental Context of Educational Work with the Youth at Risk of Social Maladjustment

Author

Bogumiła Maria Bobik

Subjects
prevention, youth, learning environment, social risks, diagnostic study, Social Sciences
Abstract

Objectives The article aims to moot various problems experienced by adolescents brought up in families and local environment prone to social pathologies. What serves as the grounds for discussion herein is the example of Bytom (a Polish city located in Upper Silesia) which, after 1989, was particularly affected by the transformations connected with the political, social and economic changes following the fall of communism. Material and methods In the course of research, the diagnostic study method was applied together with the following instruments: a questionnaire, document analysis, and observation. The survey was conducted among adolescents over the age of 13 and among their teachers in a selected school located in Bytom Results It was established that both the family and local environment affect the process of social adaptation when it comes to adolescents. The following factors can pose a threat to young people’s development: a low standard of living, bad example set by adults, poverty, unemployment, addictions, loosened family bonds, and peer pressure. Conclusions Growing up in dysfunctional environment may lead to a dearth of interests and life aspirations, limited models of spending leisure time, and a lack of authorities. The youth need support of educational and social welfare institutions.

Published
2022
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13. First observations of speed of light tracks by a fluorescence detector looking down on the atmosphere

Author

Abdellaoui, G., Abe, S., Adams Jr., J. H., Ahriche, A., Allard, D., Allen, L., Alonso, G., Anchordoqui, L., Anzalone, A., Arai, Y., Asano, K., Attallah, R., Attoui, H., Pernas, M. Ave, Bacholle, S., Bakiri, M., Baragatti, P., Barrillon, P., Bartocci, S., Bayer, J., Beldjilali, B., Belenguer, T., Belkhalfa, N., Bellotti, R., Belov, A., Belov, K., Benmessai, K., Bertaina, M., Biermann, P. L., Biktemerova, S., Bisconti, F., Blanc, N., Błȩcki, J., Blin-Bondil, S., Bobik, P., Bogomilov, M., Bozzo, E., Bruno, A., Caballero, K. S., Cafagna, F., Campana, D., Capdevielle, J-N., Capel, F., Caramete, A., Caramete, L., Carlson, P., Caruso, R., Casolino, M., Cassardo, C., Castellina, A., Catalano, C. Catalano O., Cellino, A., Chikawa, M., Chiritoi, G., Christl, M. J., Connaughton, V., Conti, L., Cordero, G., Cotto, G., Crawford, H. J., Cremonini, R., Csorna, S., Cummings, A., Dagoret-Campagne, S., De Donato, C., de la Taille, C., De Santis, C., del Peral, L., Di Martino, M., Damian, A. Diaz, Djemil, T., Dutan, I., Ebersoldt, A., Ebisuzaki, T., Engel, R., Eser, J., Fenu, F., Fernández-González, S., Fernández-Soriano, J., Ferrarese, S., Flamini, M., Fornaro, C., Fouka, M., Franceschi, A., Franchini, S., Fuglesang, C., Fujii, T., Fujimoto, J., Fukushima, M., Galeotti, P., García-Ortega, E., Garipov, G., Gascón, E., Genci, J., Giraudo, G., Alvarado, C. González, Gorodetzky, P., Greg, R., Guarino, F., Guzmán, A., Hachisu, Y., Haiduc, M., Harlov, B., Haungs, A., Carretero, J. Hernández, Cruz, W. Hidber, Ikeda, D., Inoue, N., Inoue, S., Isgrò, F., Itow, Y., Jammer, T., Jeong, S., Joven, E., Judd, E. G., Jung, A., Jochum, J., Kajino, F., Kajino, T., Kalli, S., Kaneko, I., Karadzhov, Y., Karczmarczyk, J., Katahira, K., Kawai, K., Kawasaki, Y., Kedadra, A., Khales, H., Khrenov, B. A., Kim, Jeong-Sook, Kim, Soon-Wook, Kleifges, M., Klimov, P. A., Kolev, D., Krantz, H., Kreykenbohm, I., Kudela, K., Kurihara, Y., Kusenko, A., Kuznetsov, E., La Barbera, A., Lachaud, C., Lahmar, H., Lakhdari, F., Larson, R., Larsson, O., Lee, J., Licandro, J., Campano, L. López, Maccarone, M. C., Mackovjak, S., Mahdi, M., Maravilla, D., Marcelli, L., Marcos, J. L., Marini, A., Marszał, W., Martens, K., Martín, Y., Martinez, O., Martucci, M., Masciantonio, G., Mase, K., Mastafa, M., Matev, R., Matthews, J. N., Mebarki, N., Medina-Tanco, G., Mendoza, M. A., Menshikov, A., Merino, A., Meseguer, J., Meyer, S. S., Mimouni, J., Miyamoto, H., Mizumoto, Y., Monaco, A., Ríos, J. A. Morales de los, Nagataki, C. Moretto S., Naitamor, S., Napolitano, T., Naslund, W., Nava, R., Neronov, A., Nomoto, K., Nonaka, T., Ogawa, T., Ogio, S., Ohmori, H., Olinto, A. V., Orleański, P., Osteria, G., Pagliaro, A., Painter, W., Panasyuk, M. I., Panico, B., Pasqualino, G., Parizot, E., Park, I. H., Pastircak, B., Patzak, T., Paul, T., Pérez-Grande, I., Perfetto, F., Peter, T., Picozza, P., Pindado, S., Piotrowski, L. W., Piraino, S., Placidi, L., Plebaniak, Z., Pliego, S., Pollini, A., Polonski, Z., Popescu, E. M., Prat, P., Prévôt, G., Prieto, H., Puehlhofer, G., Putis, M., Rabanal, J., Radu, A. A., Reyes, M., Rezazadeh, M., Ricci, M., Frías, M. D. Rodríguez, Rodencal, M., Ronga, F., Roudil, G., Rusinov, I., Rybczyński, M., Sabau, M. D., Cano, G. Sáez, Sagawa, H., Sahnoune, Z., Saito, A., Sakaki, N., Salazar, H., Balanzar, J. C. Sanchez, Sánchez, J. L., Santangelo, A., Sanz-Andrés, A., Palomino, M. Sanz, Saprykin, O., Sarazin, F., Sato, M., Schanz, T., Schieler, H., Scotti, V., Selmane, S., Semikoz, D., Serra, M., Sharakin, S., Shimizu, H. M., Shinozaki, K., Shirahama, T., Spataro, B., Stan, I., Sugiyama, T., Supanitsky, D., Suzuki, M., Szabelska, B., Szabelski, J., Tajima, N., Tajima, T., Takahashi, Y., Takami, H., Takeda, M., Takizawa, Y., Talai, M. C., Tenzer, C., Thomas, S. B., Tibolla, O., Tkachev, L., Tokuno, H., Tomida, T., Tone, N., Toscano, S., Traïche, M., Tsenov, R., Tsunesada, Y., Tsuno, K., Tubbs, J., Turriziani, S., Uchihori, Y., Vaduvescu, O., Valdés-Galicia, J. F., Vallania, P., Vankova, G., Vigorito, C., Villaseñor, L., Vlcek, B., von Ballmoos, P., Vrabel, M., Wada, S., Watanabe, J., Watts Jr., J., Weber, M., Muñoz, R. Weigand, Weindl, A., Wiencke, L., Wille, M., Wilms, J., Włodarczyk, Z., Yamamoto, T., Yang, J., Yano, H., Yashin, I. V., Yonetoku, D., Yoshida, S., Young, R., Zgura, I. S, Zotov, M. Yu., and Marchi, A. Zuccaro

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

EUSO-Balloon is a pathfinder mission for the Extreme Universe Space Observatory onboard the Japanese Experiment Module (JEM-EUSO). It was launched on the moonless night of the 25$^{th}$ of August 2014 from Timmins, Canada. The flight ended successfully after maintaining the target altitude of 38 km for five hours. One part of the mission was a 2.5 hour underflight using a helicopter equipped with three UV light sources (LED, xenon flasher and laser) to perform an inflight calibration and examine the detectors capability to measure tracks moving at the speed of light. We describe the helicopter laser system and details of the underflight as well as how the laser tracks were recorded and found in the data. These are the first recorded laser tracks measured from a fluorescence detector looking down on the atmosphere. Finally, we present a first reconstruction of the direction of the laser tracks relative to the detector., Comment: 18 pages, 14 figures

Published
2018
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14. Efficient allelic-drive in Drosophila.

Author

Guichard, Annabel, Haque, Tisha, Bobik, Marketta, Xu, Xiang-Ru S, Klanseck, Carissa, Kushwah, Raja Babu Singh, Berni, Mateus, Kaduskar, Bhagyashree, Gantz, Valentino M, and Bier, Ethan

Subjects
Animals, Animals, Genetically Modified, Drosophila, RNA, Guide, DNA Mutational Analysis, Inheritance Patterns, Mosaicism, Alleles, Agriculture, Female, Male, DNA End-Joining Repair, CRISPR-Cas Systems, Gene Editing, Gene Drive Technology, Genetically Modified, RNA, Guide
Abstract

Gene-drive systems developed in several organisms result in super-Mendelian inheritance of transgenic insertions. Here, we generalize this "active genetic" approach to preferentially transmit allelic variants (allelic-drive) resulting from only a single or a few nucleotide alterations. We test two configurations for allelic-drive: one, copy-cutting, in which a non-preferred allele is selectively targeted for Cas9/guide RNA (gRNA) cleavage, and a more general approach, copy-grafting, that permits selective inheritance of a desired allele located in close proximity to the gRNA cut site. We also characterize a phenomenon we refer to as lethal-mosaicism that dominantly eliminates NHEJ-induced mutations and favors inheritance of functional cleavage-resistant alleles. These two efficient allelic-drive methods, enhanced by lethal mosaicism and a trans-generational drive process we refer to as "shadow-drive", have broad practical applications in improving health and agriculture and greatly extend the active genetics toolbox.

Published
2019

15. An analytically iterative method for solving problems of cosmic-ray modulation

Author

Kolesnyk, Yuriy L., Bobik, Pavol, Shakhov, Boris A., and Putis, Marian

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - High Energy Astrophysical Phenomena, Mathematical Physics
Abstract

The development of an analytically iterative method for solving steady-state as well as unsteady-state problems of cosmic-ray (CR) modulation is proposed. Iterations for obtaining the solutions are constructed for the spherically symmetric form of the CR propagation equation. The main solution of the considered problem consists of the zero-order solution that is obtained during the initial iteration and amendments that may be obtained by subsequent iterations. The finding of the zero-order solution is based on the CR isotropy during propagation in the space, whereas the anisotropy is taken into account when finding the next amendments. To begin with, the method is applied to solve the problem of CR modulation where the diffusion coefficient $\kappa$ and the solar wind speed $u$ are constants with an Local Interstellar Spectra (LIS) spectrum. The solution obtained with two iterations was compared with an analytical solution and with numerical solutions. Finally, solutions that have only one iteration for two problems of CR modulation with $u = constant$ and the same form of LIS spectrum were obtained and tested against numerical solutions. For the first problem, $\kappa$ is proportional to the momentum of the particle $p$, so it has the form $\kappa=k_0\eta$, where $\eta=\frac{p}{m_0c}$. For the second problem, the diffusion coefficient is given in the form $\kappa=k_0\beta\eta$, where $\beta=\frac{v}{c}$ is the particle speed relative to the speed of light. There was a good matching of the obtained solutions with the numerical solutions as well as with the analytical solution for the problem where $\kappa = constant$., Comment: 13 pages, 9 figures and 2 tables

Published
2017
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16. Assessment of different markers of ovarian reserve in women with papillary thyroid cancer treated with radioactive iodine

Author

Agnieszka Adamska, Paulina Tomczuk-Bobik, Anna Beata Popławska-Kita, Katarzyna Siewko, Angelika Buczyńska, Piotr Szumowski, Łukasz Żukowski, Janusz Myśliwiec, Monika Zbucka-Krętowska, Marcin Adamski, and Adam Jacek Krętowski

Subjects
ovarian reserve, ptc, rai, amh, Diseases of the endocrine glands. Clinical endocrinology, RC648-665
Abstract

Treatment with radioactive iodine (RAI) in women with differenti ated thyroid cancer is associated with decreased serum concentrations of anti-Mülle rian hormone (AMH); however, other markers have not been investigated. Therefore, t his study aimed to evaluate the effect of RAI treatment on antral follicle count (AFC) and the serum concentration of inhibin B, follicle-stimulating hormone (FSH), and AMH in women with papillary thyroid cancer (PTC) treated with RAI. We examined 25 women at a median age of 33 years treated with a single dose of RAI. We divided the p articipants into women over (n = 11) and under 35 years of age (n = 14). Serum concentrations of inhibin B, FSH, AMH, and AFC were assessed at baseline and 1 year after RAI treatmen t. We found decreased AFC (P = 0.03), serum levels of AMH (P < 0.01), inhibin B (P = 0.03), but not FSH (P = 0.23), 1 year after RAI treatment in comparison to baseline in the who le group. When we compared serum levels of AMH in younger vs older women separate ly, we observed a significant reduction of this hormone’s serum level after RAI tr eatment in both groups (P < 0.01; P = 0.04, respectively). We concluded that RAI treatment significan tly impacts the functional ovarian reserve in premenopausal women with PTC.

Published
2021
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17. Crosstalk between cytotoxic CD8+ T cells and stressed cardiomyocytes triggers development of interstitial cardiac fibrosis in hypertensive mouse hearts

Author

Kurt Brassington, Peter Kanellakis, Anh Cao, Ban-Hock Toh, Karlheinz Peter, Alex Bobik, and Tin Kyaw

Subjects
cardiac fibrosis, CD8+ T cells, perforin, NKG2D, cardiomyocytes, RAE-1, Immunologic diseases. Allergy, RC581-607
Abstract

Graphical AbstractCardiac fibrosis developed from fibrotic remodelling due to hypertension leads to heart failure. Immune cells are abundantly accumulated in fibrotic regions, but exact mechanisms how they contributed to cardiac fibrosis are not clear. Here we demonstrated that CD8 T cells are major contributor to cardiac fibrosis in hypertensive hearts. Stressed cardiomyocytes express STING-dependent RAE-1 that activates NKG2D + CD8 T cells to induce apoptosis of stressed cardiomyocytes. Preventing STING signalling in stressed cardiomyocytes attenuates cardiac fibrosis. Pharmacologically inhibiting cardiomyocayte-RAE-1 and CD8+ T cell-NKG2D axis may be a potential therapeutic strategy to prevent cardiac fibrosis in HFpEF patients.

Published
2022
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18. Molecular Dynamics Simulations of Selective Metabolite Transport across the Propanediol Bacterial Microcompartment Shell

Author

Park, Jiyong, Chun, Sunny, Bobik, Thomas A, Houk, Kendall N, and Yeates, Todd O

Subjects
Generic health relevance, Aldehydes, Bacterial Proteins, Biological Transport, Hydrogen Bonding, Molecular Dynamics Simulation, Propylene Glycol, Salmonella enterica, Physical Sciences, Chemical Sciences, Engineering
Abstract

Bacterial microcompartments are giant protein-based organelles that encapsulate special metabolic pathways in diverse bacteria. Structural and genetic studies indicate that metabolic substrates enter these microcompartments by passing through the central pores in hexameric assemblies of shell proteins. Limiting the escape of toxic metabolic intermediates created inside the microcompartments would confer a selective advantage for the host organism. Here, we report the first molecular dynamics (MD) simulation studies to analyze small-molecule transport across a microcompartment shell. PduA is a major shell protein in a bacterial microcompartment that metabolizes 1,2-propanediol via a toxic aldehyde intermediate, propionaldehyde. Using both metadynamics and replica-exchange umbrella sampling, we find that the pore of the PduA hexamer has a lower energy barrier for passage of the propanediol substrate compared to the toxic propionaldehyde generated within the microcompartment. The energetic effect is consistent with a lower capacity of a serine side chain, which protrudes into the pore at a point of constriction, to form hydrogen bonds with propionaldehyde relative to the more freely permeable propanediol. The results highlight the importance of molecular diffusion and transport in a new biological context.

Published
2017

20. Cosmic Rays Propagation with HelMod: Difference between forward-in-time and backward-in-time approaches

Author

Della Torre, S., Bobik, P., Boschini, M. J., Gervasi, M., Grandi, D., La Vacca, G., Pensotti, S., Putis, M., Rancoita, P. G., Rozza, D., Tacconi, M., and Zannoni, M.

Subjects
Physics - Space Physics, Astrophysics - High Energy Astrophysical Phenomena
Abstract

The cosmic rays modulation inside the heliosphere is well described by a transport equation introduced by Parker in 1965. To solve this equation several approaches were followed in the past. Recently the Monte Carlo approach becomes widely used in force of his advantages with respect to other numerical methods. In the Monte Carlo approach, the transport equation is associated to a fully equivalent set of Stochastic Differential Equations. This set is used to describe the stochastic path of a quasi-particle from a source, e.g., the interstellar medium, to a specific target, e.g., a detector at Earth. In this work, we present both the Forward-in-Time and Backward-in-Time Monte Carlo solutions. We present an implementation of both algorithms in the framework of HelMod Code showing that the difference between the two approach is below 5\% that can be quoted as the systematic uncertain of the Method itself., Comment: presented at the The 34th International Cosmic Ray Conference, 30 July- 6 August, 2015, The Hague, The Netherlands

Published
2015

23. Cosmic Ray Modulation studied with HelMod Monte Carlo tool and comparison with Ulysses Fast Scan Data during consecutive Solar Minima

Author

Bobik, P., Boella, G., Boschini, M. J., Della Torre, S., Gervasi, M., Grandi, D., La Vacca, G., Kudela, K., Pensotti, S., Rancoita, P. G., Rozza, D., and Tacconi, M.

Subjects
Astrophysics - Earth and Planetary Astrophysics, Astrophysics - Solar and Stellar Astrophysics, Physics - Space Physics
Abstract

The Cosmic Rays propagation was studied in details using the HelMod-2D Monte Carlo code, that includes a general description of the diffusion tensor, and polar magnetic-field. The Numerical Approach used in this work is based on a set of Stochastic Differential Equations fully equivalent to the well know Parker Equation for the transport of Cosmic Rays. In our approach the Diffusion tensor in the frame of the magnetic field turbolence does not depends explicitly by Solar Latitude but varies with time using a diffusion parameter obtained by Neutron Monitors. The parameters of the Model were tuned using data during the solar Cycle 23 and Ulysses latitudinal Fast Scan in 1995. The actual parametrization is able to well reproduce the observed latitudinal gradient of protons and the southward shift of the minimum of latitudinal intensity. The description of the model is also available online at website www.helmod.org. The model was then applied on Pamela/Ulysses proton intensity from 2006 up to 2009. The model during this 4-year continous period agree well with both PAMELA (at 1 AU) and Ulysses data (at various solar distance and solar latitude). The agreement improves when considering the ratio between this data. Studies done also with particles with different charge (e.g. electrons) allow us to explain the presence (or not) of protons and electrons latitudinal gradients observed by Ulysses during the Latitudinal Fast Scan in 1995 and 2007.

Published
2013

24. GeoMag and HelMod webmodels version for magnetosphere and heliosphere transport of cosmic rays

Author

Bobik, P., Boschini, M. J., Consolandi, C., Della Torre, S., Gervasi, M., Grandi, D., Kudela, K., La Vacca, G., Pensotti, S., Putis, M., Rancoita, P. G., Rozza, D., and Tacconi, M.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - Earth and Planetary Astrophysics, Astrophysics - Solar and Stellar Astrophysics
Abstract

We implemented a website to deal with main effects on Cosmic Ray access to the Earth, i.e. the Solar Modulation and the Geomagnetic Field effect. In helmod.org the end user can easily access a web interface to results catalog of the HelMod Monte Carlo Code. This Model uses a Monte Carlo Approach to solves the Parker Transport Equation, obtaining a modulated proton flux for a period (monthly average) between January 1990 and december 2007. geomagsphere.org is instead based on GeoMag Backtracing Code, that solves the Lorentz equation with a Runge-Kutta method of 6th order, and, reversing charge sign and velocity, reconstruct particle trajectories in the Earth Magnetosphere back in time. We use last models of internal (IGRF-11) and external (Tsyganenko 1996 -T96- and 2005 -T05-) field components valid up to 2015. Particles are backtraced to the outer (magnetopause) or inner boundary to separate Primary (allowed trajectory) from Secondary (forbidden) Cosmic Rays. This code has been used both for reproducing known effects as East-West effect and rigidity cutoff calculations. In geomagsphere.org the user can choose the external field model from Tsyganenko (T96 or T05) and obtain for a fixed position and date from 1st Jan. 1968 (T96) and 1st Jan. 1995 (T05) respectively till 31$^{st}$ Dec 2012, the vertical rigidity cutoff estimation obtained with the backtracing technique with a rigidity step of 0.1 GV. For a more precise calculation (0.01 GV), requiring more CPU time, results are sent to the user by email (mail model)

Published
2013

25. Suprathermal particle addition to solar wind pressure: possible influence on magnetospheric transmissivity of low energy cosmic rays?

Author

Bobik, P., Boschini, M. J., Consolandi, C., Della Torre, S., Gervasi, M., Grandi, D., Kudela, K., La Vacca, G., Mallamaci, M., Pensotti, S., Rancoita, P. G., Rozza, D., and Tacconi, M.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - Earth and Planetary Astrophysics, Astrophysics - Solar and Stellar Astrophysics, Physics - Space Physics
Abstract

Energetic (suprathermal) solar particles, accelerated in the interplanetary medium, contribute to the solar wind pressure, in particular during high solar activity periods. We estimated the effect of the increase of solar wind pressure due to suprathermal particles on magnetospheric transmissivity of galactic cosmic rays in the case of one recent solar event.

Published
2013

26. An evaluation of the exposure in nadir observation of the JEM-EUSO mission

Author

Adams, J. H., Ahmad, S., Albert, J. -N., Allard, D., Ambrosio, M., Anchordoqui, L., Anzalone, A., Arai, Y., Aramo, C., Asano, K., Ave, M., Barrillon, P., Batsch, T., Bayer, J., Belenguer, T., Bellotti, R., Berlind, A. A., Bertaina, M., Biermann, P. L., Biktemerova, S., Blaksley, C., Blecki, J., Blin-Bondil, S., Bluemer, J., Bobik, P., Bogomilov, M., Bonamente, M., Briggs, M. S., Briz, S., Bruno, A., Cafagna, F., Campana, D., Capdevielle, J-N., Caruso, R., Casolino, M., Cassardo, C., Castellini, G., Catalano, O., Cellino, A., Chikawa, M., Christl, M. J., Connaughton, V., Cortes, J. F., Crawford, H. J., Cremonini, R., Csorna, S., D'Olivo, J. C., Dagoret-Campagne, S., de Castro, A. J., De Donato, C., de la Taille, C., del Peral, L., Dell'Oro, A., De Pascale, M. P., Di Martino, M., Distratis, G., Dupieux, M., Ebersoldt, A., Ebisuzaki, T., Engel, R., Falk, S., Fang, K., Fenu, F., Fernandez-Gomez, I., Ferrarese, S., Franceschi, A., Fujimoto, J., Galeotti, P., Garipov, G., Geary, J., Giaccari, U. G., Giraudo, G., Gonchar, M., Alvarado, C. Gonzalez, Gorodetzky, P., Guarino, F., Guzman, A., Hachisu, Y., Harlov, B., Haungs, A., Carretero, J. Hernandez, Higashide, K., Iguchi, T., Ikeda, H., Inoue, N., Inoue, S., Insolia, A., Isgrio, F., Itow, Y., Joven, E., Judd, E. G., Jung, A., Kajino, F., Kajino, T., Kaneko, I., Karadzhov, Y., Karczmarczyk, J., Katahira, K., Kawai, K., Kawasaki, Y., Keilhauer, B., Khrenov, B. A., Kim, Jeong-Sook, Kim, Soon-Wook, Kim, Sug-Whan, Kleifges, M., Klimov, P. A., Ko, S. H., Kolev, D., Kreykenbohm, I., Kudela, K., Kurihara, Y., Kuznetsov, E., La Rosa, G., Lee, J., Licandro, J., Lim, H., Lopez, F., Maccarone, M. C., Mannheim, K., Marcelli, L., Marini, A., Martin-Chassard, G., Martinez, O., Masciantonio, G., Mase, K., Matev, R., Maurissen, A., Medina-Tanco, G., Mernik, T., Miyamoto, H., Miyazaki, Y., Mizumoto, Y., Modestino, G., Monnier-Ragaigne, D., Rios, J. A. Morales de los, Mot, B., Murakami, T., Nagano, M., Nagata, M., Nagataki, S., Nakamura, T., Nam, J. W., Nam, S., Nam, K., Napolitano, T., Naumov, D., Neronov, A., Nomoto, K., Ogawa, T., Ohmori, H., Olinto, A. V., Orleanski, P., Osteria, G., Pacheco, N., Panasyuk, M. I., Parizot, E., Park, I. H., Pastircak, B., Patzak, T., Paul, T., Pennypacker, C., Peter, T., Picozza, P., Pollini, A., Prieto, H., Reardon, P., Reina, M., Reyes, M., Ricci, M., Rodriguez, I., Frias, M. D. Rodriguez, Ronga, F., Rothkaehl, H., Roudil, G., Rusinov, I., Rybczynski, M., Sabau, M. D., Cano, G. Saez, Saito, A., Sakaki, N., Sakata, M., Salazar, H., Sanchez, S., Santangelo, A., Cruz, L. Santiago, Palomino, M. Sanz, Saprykin, O., Sarazin, F., Sato, H., Sato, M., Schanz, T., Schieler, H., Scotti, V., Scuderi, M., Segreto, A., Selmane, S., Semikoz, D., Serra, M., Sharakin, S., Shibata, T., Shimizu, H. M., Shinozaki, K., Shirahama, T., Siemieniec-Ozieb, G., Lopez, H. H. Silva, Sledd, J., Slominska, K., Sobey, A., Sugiyama, T., Supanitsky, D., Suzuki, M., Szabelska, B., Szabelski, J., Tajima, F., Tajima, N., Tajima, T., Takahashi, Y., Takami, H., Takeda, M., Takizawa, Y., Tenzer, C., Tibolla, O., Tkachev, L., Tomida, T., Tone, N., Trillaud, F., Tsenov, R., Tsuno, K., Tymieniecka, T., Uchihori, Y., Vaduvescu, O., Valdes-Galicia, J. F., Vallania, P., Valore, L., Vankova, G., Vigorito, C., Villasenor, L., von Ballmoos, P., Wada, S., Watanabe, J., Watanabe, S., Watts, J., Weber, M., Weiler, T. J., Wibig, T., Wiencke, L., Wille, M., Wilms, J., Wlodarczyk, Z., Yamamoto, T., Yamamoto, Y., Yang, J., Yano, H., Yashin, I. V., Yonetoku, D., Yoshida, K., Yoshida, S., Young, R., Zamora, A., and Marchi, A. Zuccaro

Subjects
Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

We evaluate the exposure during nadir observations with JEM-EUSO, the Extreme Universe Space Observatory, on-board the Japanese Experiment Module of the International Space Station. Designed as a mission to explore the extreme energy Universe from space, JEM-EUSO will monitor the Earth's nighttime atmosphere to record the ultraviolet light from tracks generated by extensive air showers initiated by ultra-high energy cosmic rays. In the present work, we discuss the particularities of space-based observation and we compute the annual exposure in nadir observation. The results are based on studies of the expected trigger aperture and observational duty cycle, as well as, on the investigations of the effects of clouds and different types of background light. We show that the annual exposure is about one order of magnitude higher than those of the presently operating ground-based observatories., Comment: published in Astroparticle Physics by the JEM-EUSO Collaboration

Published
2013
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27. Banco Interamericano de Desenvolvimento (BID) no espaço-tempo: uma análise crítica sobre seu papel no financiamento da integração regional

Author

José Alex Rego Soares and Márcio Bobik Braga

Subjects
Exclusão Financeira, BID, Integração Regional, Crédito, Renda, Human ecology. Anthropogeography, GF1-900, Physical geography, GB3-5030, Geography (General), G1-922
Abstract

O objetivo do artigo consiste em analisar a desempenho do BID enquanto banco de integração regional e o tratamento dispensado ao circulo vicioso crédito-renda no período de sua criação até o começo do século XX. Dadas as circunstâncias comumente apresentadas em regiões com alta desigualdade de renda, a promoção do crédito fica presa nesse circuito vicioso, pois só há acesso ao crédito quem possui renda. Assim sendo, problematizamos como o Banco Interamericano não foi capaz de se consolidar como uma instituição financeira internacional de primeira linha no Sistema Financeiro Mundial (SFM). O BID tampouco ocupa o espaço de agente facilitador da integração regional na acepção da compactação entre espaço e tempo como dinamizador do crédito, uma vez que o desenho institucional do BID impossibilita o crédito no processo de integração regional.

Published
2021
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28. JEM-EUSO experiment for extreme energy cosmic ray observation

Author

Pastirčák, Blahoslav, Bobík, Pavol, and Kudela, Karel

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - High Energy Astrophysical Phenomena, Physics - Space Physics
Abstract

The planned JEM-EUSO (Extreme Universe Space Observatory onboard the ISS Japanese Experimental Module) will measure the energy spectra of cosmic rays up to the range of 1000 EeV and will search for direction to their sources. It will observe the extensive air showers generated in the atmosphere by high energy cosmic ray primary particle from the space. The instantaneous aperture of the telescope will exceed by one order the aperture of the largest ground based detectors. JEM-EUSO apparatus is a large telescope with a diameter of 2.5 m with fast UV camera. Slovakia is responsible for the determination of the UV background, which influences the operational efficiency of the experiment and for the analysis of fake trigger events., Comment: Physics in Collision, Slovakia, 2012

Published
2012

29. Latitudinal Dependence of Cosmic Rays Modulation at 1 AU and Interplanetary-Magnetic-Field Polar Correction

Author

Bobik, P., Boella, G., Boschini, M. J., Consolandi, C., Della Torre, S., Gervasi, M., Grandi, D., Kudela, K., Pensotti, S., Rancoita, P. G., Rozza, D., and Tacconi, M.

Subjects
Astrophysics - Solar and Stellar Astrophysics, Astrophysics - Cosmology and Nongalactic Astrophysics, Astrophysics - Earth and Planetary Astrophysics, Astrophysics - Astrophysics of Galaxies
Abstract

The cosmic rays differential intensity inside the heliosphere, for energy below 30 GeV/nuc, depends on solar activity and interplanetary magnetic field polarity. This variation, termed solar modulation, is described using a 2-D (radius and colatitude) Monte Carlo approach for solving the Parker transport equation that includes diffusion, convection, magnetic drift and adiabatic energy loss. Since the whole transport is strongly related to the interplanetary magnetic field (IMF) structure, a better understanding of his description is needed in order to reproduce the cosmic rays intensity at the Earth, as well as outside the ecliptic plane. In this work an interplanetary magnetic field model including the standard description on ecliptic region and a polar correction is presented. This treatment of the IMF, implemented in the HelMod Monte Carlo code (version 2.0), was used to determine the effects on the differential intensity of Proton at 1\,AU and allowed one to investigate how latitudinal gradients of proton intensities, observed in the inner heliosphere with the Ulysses spacecraft during 1995, can be affected by the modification of the IMF in the polar regions., Comment: accepted for publication inAdvances in Astronomy

Published
2012
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30. Poly(sodium acrylate)-Modified Magnetite Nanoparticles for Separation of Heavy Metals from Aqueous Solutions

Author

Magdalena Bobik, Irena Korus, Karol Synoradzki, Jacek Wojnarowicz, Dorota Biniaś, and Włodzimierz Biniaś

Subjects
magnetic iron oxides, poly(sodium acrylate), nanoparticles, adsorption, heavy metals, Technology, Electrical engineering. Electronics. Nuclear engineering, TK1-9971, Engineering (General). Civil engineering (General), TA1-2040, Microscopy, QH201-278.5, Descriptive and experimental mechanics, QC120-168.85
Abstract

Two types of magnetite nanoparticles: unmodified (Fe3O4 NPs), and modified with poly(sodium acrylate) (Fe3O4/PSA NPs) were synthesized by the co-precipitation method and characterized using different techniques: X-ray diffraction (XRD), transmission electron microscopy (TEM), nanoparticle tracking analysis (NTA), Brunauer–Emmett–Teller (BET) adsorption, Fourier-transform infrared spectroscopy (FTIR). Additionally, magnetic properties and the effect of pH on the zeta potential were analyzed for both types of nanoparticles. Magnetites were used as adsorbents for seven heavy metal ions (Zn(II), Cu(II), Ni(II), Cd(II), Pb(II), Cr(III), Cr(VI)) within the pH range of 3–7. Research revealed nanometric particle sizes, a specific surface area of 140–145 m2/g, and superparamagnetic properties of both tested materials. Moreover, the presence of PSA functional groups in modified magnetite was confirmed, which lowered the pH of the isoelectric point. Both types of magnetite were effective metal ion adsorbents, with metal cations more effectively removed on Fe3O4/PSA NPs and Cr(VI) anions on Fe3O4 NPs. The adsorption of most of the examined cations (performed at pH = 5) can be well described by the Langmuir isotherm model, whereas the adsorption of Cr(VI) ions on modified magnetite correlated better with the Freundlich model. The Dubinin–Radushkevich model confirmed that chemisorption is the predominant process. The adsorption of all metal ions was well-characterized by the pseudo-second-order kinetic model.

Published
2022
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31. The JEM-EUSO Mission: Status and Prospects in 2011

Author

Collaboration, The JEM-EUSO, Adams Jr, J. H., Ahmad, S., Albert, J. -N., Allard, D., Ambrosio, M., Anchordoqui, L., Anzalone, A., Arai, Y., Aramo, C., Asano, K., Barrillon, P., Batsch, T., Bayer, J., Belenguer, T., Bellotti, R., Berlind, A. A., Bertaina, M., Biermann, P. L., Biktemerova, S., Blaksley, C., Blecki, J., Blin-Bondil, S., Bluemer, J., Bobik, P., Bogomilov, M., Bonamente, M., Briggs, M. S., Briz, S., Bruno, A., Cafagna, F., Campana, D., Capdevielle, J-N., Caruso, R., Casolino, M., Cassardo, C., Castellini, G., Catalano, O., Cellino, A., Chikawa, M., Christl, M. J., Connaughton, V., Cortes, J. F., Crawford, H. J., Cremonini, R., Csorna, S., D'Olivo, J. C., Dagoret-Campagne, S., de Castro, A. J., De Donato, C., de la Taille, C., De Pascale, M. P., del Peral, L., Dell'Oro, A., Di Martino, M., Distrati, G., Dupieux, M., Ebersoldt, A., Ebisuzaki, T., Engel, R., Falk, S., Fang, K., Fenu, F., Ferrarese, S., Fernandez-Gomez, I., Franceschi, A., Fujimoto, J., Galeotti, P., Garipov, G., Geary, J., Giaccari, U. G., Giraudo, G., Gonchar, M., Alvarado, C. Gonzalez, Gorodetzky, P., Guarino, F., Guzman, A., Hachisu, Y., Harlov, B., Haungs, A., Carretero, J. Hernandez, Higashide, K., Iguchi, T., Ikeda, H., Inoue, N., Inoue, S., Insolia, A., Isgro, F., Itow, Y., Joven, E., Judd, E. G., Jung, A., Kajino, F., Kajino, T., Kaneko, I., Karadzhov, Y., Karczmarczyk, J., Katahira, K., Kawai, K., Kawasaki, Y., Keilhauer, B., Khrenov, B. A., Kim, Jeong-Sook, Kim, Soon-Wook, Kim, Sug-Whan, Kleifges, M., Klimov, P. A., Ko, S. H., Kolev, D., Kreykenbohm, I., Kudela, K., Kurihara, Y., Kuznetsov, E., La Rosa, G., Lee, J., Licandro, J., Lim, H., Lopez, F., Maccarone, M. C., Marcelli, L., Marini, A., Martin-Chassard, G., Martinez, O., Masciantonio, G., Mase, K., Matev, R., Maurissen, A., Medina-Tanco, G., Mernik, T., Miyamoto, H., Miyazaki, Y., Mizumoto, Y., Modestino, G., Monnier-Ragaigne, D., Rıos, J. A. Morales de los, Mot, B., Murakami, T., Nagano, M., Nagata, M., Nagataki, S., Nam, J. W., Nam, S., Nam, K., Napolitano, T., Naumov, D., Neronov, A., Nomoto, K., Ogawa, T., Ohmori, H., Olinto, A. V., Orleanski, P., Osteria, G., Pacheco, N., Panasyuk, M. I., Parizot, E., Park, I. H., Pastircak, B., Patzak, T., Paul, T., Pennypacker, C., Peter, T., Picozza, P., Pollini, A., Prieto, H., Reardon, P., Reina, M., Reyes, M., Ricci, M., Rodrıguez, I., Frıas, M. D. Rodrıguez, Ronga, F., Rothkaehl, H., Roudil, G., Rusinov, I., Rybczynski, M., Sabau, M. D., Cano, G. Saez, Saito, A., Sakaki, N., Sakata, M., Salazar, H., Sanchez, S., Santangelo, A., Cruz, L. Santiago, Palomino, M. Sanz, Saprykin, O., Sarazin, F., Sato, H., Sato, M., Schanz, T., Schieler, H., Scotti, V., Scuderi, M., Segreto, A., Selmane, S., Semikoz, D., Serra, M., Sharakin, S., Shibata, T., Shimizu, H. M., Shinozaki, K., Shirahama, T., Siemieniec-Ozieblo, G., Lopez, H. H. Silva, Sledd, J., Slominska, K., Sobey, A., Sugiyama, T., Supanitsky, D., Suzuki, M., Szabelska, B., Szabelski, J., Tajima, F., Tajima, N., Tajima, T., Takami, H., Nakamura, T., Takeda, M., Takahashi, Y., Takizawa, Y., Tenzer, C., Tkachev, L., Tomida, T., Tone, N., Trillaud, F., Tsenov, R., Tsuno, K., Tymieniecka, T., Uchihori, Y., Vaduvescu, O., Valdes-Galicia, J. F., Vallania, P., Valore, L., Vankova, G., Vigorito, C., Villasenor, L., von Ballmoos, P., Wada, S., Watanabe, J., Watanabe, S., Watts Jr, J., Weber, M., Weiler, T. J., Wibig, T., Wiencke, L., Wille, M., Wilms, J., Wlodarczyk, Z., Yamamoto, T., Yamamoto, Y., Yang, J., Yano, H., Yashin, I. V., Yonetoku, D., Yoshida, K., Yoshida, S., Young, R., Zamora, A., and Marchi, A. Zuccaro

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - High Energy Astrophysical Phenomena
Abstract

Contributions of the JEM-EUSO Collaboration to the 32nd International Cosmic Ray Conference, Beijing, August, 2011., Comment: 33 contributions plus index

Published
2012

32. Heliosphere Dimension and Cosmic Ray Modulation

Author

Bobik, P., Boschini, M. J., Consolandi, C., Della Torre, S., Gervasi, M., Grandi, D., Kudela, K., Noventa, F., Pensotti, S., Rancoita, P. G., and Rozza, D.

Subjects
Astrophysics - Solar and Stellar Astrophysics, Astrophysics - Earth and Planetary Astrophysics
Abstract

The differential intensities of Cosmic Rays at Earth were calculated using a 2D stochastic Montecarlo diffusion code and compared with observation data. We evaluated the effect of stretched and compressed heliospheres on the Cosmic Ray intensities at the Earth. This was studied introducing a dependence of the diffusion parameter on the heliospherical size. Then, we found that the optimum value of the heliospherical radius better accounting for experimental data. We also found that the obtained values depends on solar activity. Our results are compatible with Voyager observations and with models of heliospherical size modulation., Comment: To appear on the Proceedings of the 13th ICATPP Conference on Astroparticle, Particle, Space Physics and Detectors for Physics Applications, Villa Olmo (Como, Italy), 3-7 October, 2011, to be published by World Scientific, Singapore (2012)

Published
2011
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33. Systematic Investigation of Solar Modulation of Galactic Protons for Solar Cycle 23 using a Monte Carlo Approach with Particle Drift Effects and Latitudinal Dependence

Author

Bobik, P., Boella, G., Boschini, M. J., Consolandi, C., Della Torre, S., Gervasi, M., Grandi, D., Kudela, K., Pensotti, S., Rancoita, P. G., and Tacconi, M.

Subjects
Astrophysics - Solar and Stellar Astrophysics, Astrophysics - Earth and Planetary Astrophysics
Abstract

A propagation model of galactic cosmic protons through the Heliosphere was implemented using a 2-D Monte Carlo approach to determine the differential intensities of protons during the solar cycle 23. The model includes the effects due to the variation of solar activity during the propagation of cosmic rays from the boundary of the heliopause down to Earth's position. Drift effects are also accounted for. The simulated spectra were found in agreement with those obtained with experimental observations carried out by BESS, AMS and PAMELA collaborations. In addition, the modulated spectrum determined with the present code for the year 1995 exhibits the latitudinal gradient and equatorial southward offset minimum found by Ulysses fast scan in 1995., Comment: accepted for publication on The Astrophysical Journal

Published
2011
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34. Antiproton modulation in the Heliosphere and AMS-02 antiproton over proton ratio prediction

Author

Bobik, P., Boschini, M. J., Consolandi, C., Della Torre, S., Gervasi, M., Grandi, D., Kudela, K., Pensotti, S., and Rancoita, P. G.

Subjects
Astrophysics - Earth and Planetary Astrophysics
Abstract

We implemented a quasi time-dependent 2D stochastic model of solar modulation describing the transport of cosmic rays (CR) in the heliosphere. Our code can modulate the Local Interstellar Spectrum (LIS) of a generic charged particle (light cosmic ions and electrons), calculating the spectrum at 1AU. Several measurements of CR antiparticles have been performed. Here we focused our attention on the CR antiproton component and the antiproton over proton ratio. We show that our model, using the same heliospheric parameters for both particles, fit the observed anti-p/p ratio. We show a good agreement with BESS-97 and PAMELA data and make a prediction for the AMS-02 experiment.

Published
2011
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35. Proton and antiproton modulation in the heliosphere for different solar conditions and AMS-02 measurements prediction

Author

Bobik, P., Boschini, M. J., Consolandi, C., Della Torre, S., Gervasi, M., Grandi, D., Kudela, K., Pensotti, S., and Rancoita, P. G.

Subjects
Astrophysics - Earth and Planetary Astrophysics
Abstract

Galactic Cosmic Rays (GCRs) are mainly protons confined in the galactic magnetic field to form an isotropic flux inside the galaxy. Before reaching the Earth orbit they enter the Heliosphere and undergo diffusion, convection, magnetic drift and adiabatic energy loss. The result is a reduction of particles flux at low energy (below 10 GeV), called solar modulation. We realized a quasi time-dependent 2D Stochastic Simulation of Solar Modulation that is able to reproduce CR spectra once known the Local Interstellar Spectrum (LIS). We were able to estimate the different behaviors associated to the polarity dependence of the Heliospheric modulation for particles as well as for antiparticles. We show a good agreement with the antiproton/proton ratio measured by AMS-01, Pamela, BESS, Heat and Caprice and we performed a prediction for the AMS-02 Experiment.

Published
2010
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36. Proton Modulation in the Heliosphere for Different Solar Conditions and Prediction for AMS-02

Author

Bobik, P., Boella, G., Boschini, M. J., Consolandi, C., Della Torre, S., Gervasi, M., Grandi, D., Kudela, K., Memola, E., Pensotti, S., Rancoita, P. G., and Tacconi, M.

Subjects
Astrophysics - Earth and Planetary Astrophysics
Abstract

Spectra of Galactic Cosmic Rays (GCRs) measured at the Earth are the combination of several processes: sources production and acceleration, propagation in the interstellar medium and propagation in the heliosphere. Inside the solar cavity the flux of GCRs is reduced due to the solar modulation, the interaction which they have with the interplanetary medium. We realized a 2D stochastic simulation of solar modulation to reproduce CR spectra at the Earth, and evaluated the importance in our results of the Local Interstellar Spectrum (LIS) model and its agreement with data at high energy. We show a good agreement between our model and the data taken by AMS-01 and BESS experiments during periods with different solar activity conditions. Furthermore we made a prediction for the flux which will be measured by AMS-02 experiment., Comment: Accepted for publication in the Proceedings of the ICATPP Conference on Cosmic Rays for Particle and Astroparticle Physics, Villa Olmo (Como, Italy), 7-8 October, 2010, to be published by World Scientific (Singapore)

Published
2010
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37. Electron and Positron solar modulation and prediction for AMS-02

Author

Bobik, P., Boschini, M. J., Consolandi, C., Della Torre, S., Gervasi, M., Grandi, D., Kudela, K., Pensotti, S., and Rancoita, P. G.

Subjects
Astrophysics - Solar and Stellar Astrophysics
Abstract

The solar modulation, a combination of diffusion, convection, magnetic drift and energy loss inside the heliosphere is usually seen as a depletion in the Galactic cosmic ray (CR) flux at low energy (less than 10 GeV/nuc). Antiparticles such as antiprotons or positrons undergo the same processes of respective particles but with a different magnitude depending on the Solar magnetic field polarity. For electrons and positrons, due to the small mass, energy loss mechanisms as inverse compton, synchrotron, bremsstrahlung and ionization have to be taken into account, together with the typical adiabatic losses considered in the heliosphere. We developed a Monte Carlo stochastic simulation with the aim to compare the solar modulation of particles and antiparticles in the same observation period. We are able to estimate the different behaviours associated to the charge sign dependent processes of the heliospheric modulation. We compared the simulated positron fraction with measurements performed by AMS-01 and PAMELA. We also present the prediction for the AMS-02 experiment., Comment: Accepted for publication in the Proceedings of the ICATPP Conference on Cosmic Rays for Particle and Astroparticle Physics, Villa Olmo (Como, Italy), 7--8 October, 2010, to be published by World Scientific

Published
2010
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38. Efficient allelic-drive in Drosophila

Author

Annabel Guichard, Tisha Haque, Marketta Bobik, Xiang-Ru S. Xu, Carissa Klanseck, Raja Babu Singh Kushwah, Mateus Berni, Bhagyashree Kaduskar, Valentino M. Gantz, and Ethan Bier

Subjects
Science
Abstract

Gene-drives use CRISPR-Cas9 to be transmitted in a super-Mendelian fashion. Here the authors develop an allelic-drive for selective inheritance of a desired allele.

Published
2019
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39. Zagrożenie wypaleniem zawodowym terapeutów zajęciowych pracujących z osobami z niepełnosprawnością intelektualną

Author

Bogumiła Bobik

Subjects
terapia zajęciowa, terapeuta zajęciowy, profesja społeczna, wypalenie zawodowe, Education, Psychology, BF1-990
Abstract

Artykuł porusza problem zagrożenia wypaleniem zawodowym w środowisku terapeutów zajęciowych pracujących z osobami z niepełnosprawnością intelektualną. Ważny z punktu widzenia różnych dyscyplin naukowych, między innymi pedagogiki specjalnej, psychologii, medycyny czy profilaktyki społecznej. Opisane w artykule badania przeprowadzono w warsztatach terapii zajęciowej, wykorzystując metodę sondażu diagnostycznego i technikę ankiety. Badania pozwoliły na określenie indywidualnych, środowiskowych i organizacyjnych zagrożeń wypaleniem zawodowym. Wskazały na najczęściej występujące składniki wypalenia zawodowego. Nakreśliły kierunki indywidualnych działań zapobiegających zjawisku wypalenia zawodowego.

Published
2018
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40. MCPdb: The bacterial microcompartment database.

Author

Jessica M Ochoa, Kaylie Bair, Thomas Holton, Thomas A Bobik, and Todd O Yeates

Subjects
Medicine, Science
Abstract

Bacterial microcompartments are organelle-like structures composed entirely of proteins. They have evolved to carry out several distinct and specialized metabolic functions in a wide variety of bacteria. Their outer shell is constructed from thousands of tessellating protein subunits, encapsulating enzymes that carry out the internal metabolic reactions. The shell proteins are varied, with single, tandem and permuted versions of the PF00936 protein family domain comprising the primary structural component of their polyhedral architecture, which is reminiscent of a viral capsid. While considerable amounts of structural and biophysical data have been generated in the last 15 years, the existing functionalities of current resources have limited our ability to rapidly understand the functional and structural properties of microcompartments (MCPs) and their diversity. In order to make the remarkable structural features of bacterial microcompartments accessible to a broad community of scientists and non-specialists, we developed MCPdb: The Bacterial Microcompartment Database (https://mcpdb.mbi.ucla.edu/). MCPdb is a comprehensive resource that categorizes and organizes known microcompartment protein structures and their larger assemblies. To emphasize the critical roles symmetric assembly and architecture play in microcompartment function, each structure in the MCPdb is validated and annotated with respect to: (1) its predicted natural assembly state (2) tertiary structure and topology and (3) the metabolic compartment type from which it derives. The current database includes 163 structures and is available to the public with the anticipation that it will serve as a growing resource for scientists interested in understanding protein-based metabolic organelles in bacteria.

Published
2021
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42. The Cobalamin-Dependent Gene Cluster of Listeria monocytogenes: Implications for Virulence, Stress Response, and Food Safety

Author

Justin M. Anast, Thomas A. Bobik, and Stephan Schmitz-Esser

Subjects
Listeria monocytogenes, food safety, virulence, stress survival, cobalamin, ethanolamine, Microbiology, QR1-502
Abstract

Several genes of the eut, pdu, and cob/cbi operons are responsible for the metabolism of ethanolamine (EA) and 1,2-propanediol (PD) and are essential during the pathogenic lifecycles of various enteric pathogens. Studies concerning EA and PD metabolism have primarily focused on bacterial genera from the family Enterobacteriaceae, especially the genus Salmonella. Listeria monocytogenes is a member of the Firmicutes phylum and is the causative agent of the rare but highly fatal foodborne disease listeriosis. The eut, pdu, and cob/cbi operons are organized as a single large locus collectively referred to as the cobalamin-dependent gene cluster (CDGC). The CDGC is well conserved in L. monocytogenes; however, functional characterization of the genes in this cluster and how they may contribute to Listeria virulence and stress tolerance in food production environments is highly limited. Previous work suggests that the degradation pathway of PD is essential for L. monocytogenes establishment in the gastrointestinal tract. In contrast, EA metabolism may be more important during intracellular replication. Other studies indicate that the CDGC is utilized when L. monocytogenes is exposed to food and food production relevant stress conditions. Perhaps most noteworthy, L. monocytogenes exhibits attenuated growth at cold temperatures when a key EA utilization pathway gene was deleted. This review aims to summarize the current knowledge of these pathways in L. monocytogenes and their significance in virulence and stress tolerance, especially considering recent developments.

Published
2020
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44. B Cell and CD4 T Cell Interactions Promote Development of Atherosclerosis

Author

Christopher Tay, Peter Kanellakis, Hamid Hosseini, Anh Cao, Ban-Hock Toh, Alex Bobik, and Tin Kyaw

Subjects
atherosclerosis, B cells, CD4 T cells, MHCII, CD40, Immunologic diseases. Allergy, RC581-607
Abstract

Interaction between B and CD4 T cells is crucial for their optimal responses in adaptive immunity. Immune responses augmented by their partnership promote chronic inflammation. Here we report that interaction between B and CD4 T cells augments their atherogenicity to promote lipid-induced atherosclerosis. Genetic deletion of the gene encoding immunoglobulin mu (μ) heavy chain (μMT) in ApoE−/− mice resulted in global loss of B cells including those in atherosclerotic plaques, undetectable immunoglobulins and impaired germinal center formation. Despite unaffected numbers in the circulation and peripheral lymph nodes, CD4 T cells were also reduced in spleens as were activated and memory CD4 T cells. In hyperlipidemic μMT−/− ApoE−/− mice, B cell deficiency decreased atherosclerotic lesions, accompanied by absence of immunoglobulins and reduced CD4 T cell accumulation in lesions. Adoptive transfer of B cells deficient in either MHCII or co-stimulatory molecule CD40, molecules required for B and CD4 T cell interaction, into B cell-deficient μMT−/− ApoE−/− mice failed to increase atherosclerosis. In contrast, wildtype B cells transferred into μMT−/− ApoE−/− mice increased atherosclerosis and increased CD4 T cells in lesions including activated and memory CD4 T cells. Transferred B cells also increased their expression of atherogenic cytokines IL-1β, TGF-β, MCP-1, M-CSF, and MIF, with partial restoration of germinal centers and plasma immunoglobulins. Our study demonstrates that interaction between B and CD4 T cells utilizing MHCII and CD40 is essential to augment their function to increase atherosclerosis in hyperlipidemic mice. These findings suggest that targeting B cell and CD4 T cell interaction may be a therapeutic strategy to limit atherosclerosis progression.

Published
2020
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45. Statistical Error for Cosmic Rays Modulation Evaluated by SDE Backward in Time Method for 1D Model

Author

Viacheslav Mykhailenko and Pavol Bobik

Subjects
cosmic rays, heliosphere, Parker equation, Thermodynamics, QC310.15-319, Descriptive and experimental mechanics, QC120-168.85
Abstract

The propagation of cosmic rays through the heliosphere has been solved for more than half a century by stochastic methods based on Ito’s lemma. This work presents the estimation of statistical error of solution of Fokker–Planck equation by the 1D backward in time stochastic differential equations method. The error dependence on simulation statistics and energy is presented for different combinations of input parameters. The 1% precision criterion in mean value units of intensity standard deviation is defined as a function of solar wind velocity and diffusion coefficient value.

Published
2022
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46. Epitope-Specific Response of Human Milk Immunoglobulins in COVID-19 Recovered Women

Author

Tatyana V. Bobik, Nikita N. Kostin, George A. Skryabin, Polina N. Tsabai, Maria A. Simonova, Vera D. Knorre, Yuliana A. Mokrushina, Ivan V. Smirnov, Julia A. Kosolapova, Valentina V. Vtorushina, Evgeniya V. Inviyaeva, Evgeniya Polushkina, Ulyana L. Petrova, Anna V. Levadnaya, Lyubov V. Krechetova, Roman G. Shmakov, Gennadiy T. Sukhikh, and Alexander G. Gabibov

Subjects
human milk, breastfeeding, SARS-CoV-2, class A immunoglobulins, class G immunoglobulins, class M immunoglobulins, Medicine
Abstract

The breastfeeding of infants by mothers who are infected with SARS-CoV-2 has become a dramatic healthcare problem. The WHO recommends that infected women should not abandon breastfeeding; however, there is still the risk of contact transmission. Convalescent donor milk may provide a defense against the aforementioned issue and can eliminate the consequences of artificial feeding. Therefore, it is vital to characterize the epitope-specific immunological landscape of human milk from women who recovered from COVID-19. We carried out a comprehensive ELISA-based analysis of blood serum and human milk from maternity patients who had recovered from COVID-19 at different trimesters of pregnancy. It was found that patients predominantly contained SARS-CoV-2 N-protein-specific immunoglobulins and had manifested the antibodies for all the antigens tested in a protein-specific and time-dependent manner. Women who recovered from COVID-19 at trimester I–II showed a noticeable decrease in the number of milk samples with sIgA specific to the N-protein, linear NTD, and RBD-SD1 epitopes, and showed an increase in samples with RBD conformation-dependent sIgA. S-antigens were found to solely induce a sIgA1 response, whereas N-protein sIgA1 and sIgA2 subclasses were involved in 100% and 33% of cases. Overall, the antibody immunological landscape of convalescent donor milk suggests that it may be a potential defense agent against COVID-19 for infants, conferring them with a passive immunity.

Published
2021
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49. Interleukin (IL)-23, IL-31, and IL-33 Play a Role in the Course of Autoimmune Endocrine Diseases

Author

Janyga, Szymon, Kajdaniuk, Dariusz, Czuba, Zenon, Ogrodowczyk-Bobik, Monika, Urbanek, Agata, Kos-Kudła, Beata, and Marek, Bogdan

Abstract

Background: Interleukins (IL)-23, 31, and 33 are involved in the regulation of T helper 17 (Th17)/regulatory T (Treg) cells balance. The role of IL-23, 31 and 33 in non-endocrine autoimmune diseases has been confirmed. Data on the involvement of these cytokines in endocrine autoimmune diseases are limited.Objective: This study aimed to determine the involvement of cytokines regulating the T helper 17 (Th17)/regulatory T (Treg) cells axis in the course of autoimmune endocrine diseases.Methods: A total number of 80 participants were divided into 4 groups: the autoimmune polyendocrine syndrome (APS) group consisting of APS type 2 (APS-2) and type 3 (APS-3) subgroups, the Hashimoto's thyroiditis (HT) group, the Graves’ disease (GD) group and the control (C) group.Fifteen cytokines related to Th17 and Treg lymphocytes were determined in the serum of all participants. Results: Higher levels of IL-23 and IL-31 were found in the APS, GD, and HT groups compared to the C group. Higher levels of IL-23 and IL-31 were also observed in the APS-2 group, in contrast to the APS-3 group. Correlation analysis of variables in the groups showed a statistically significant correlation between the cytokines IL-23, IL-31, and IL-33 in the APS and APS-2 groups, but no correlation in the APS-3 and C groups.Conclusion: IL-23 and IL-31 are independent factors in the course of HT, GD, and APS-2, in contrast to APS-3. The positive correlation between IL-23 and IL-31, IL-23 and IL-33, and between IL-31 and IL-33 in the APS, APS-2 groups, but the lack of correlation in the APS-3 and C groups may further suggest the involvement of these cytokines in the course of Addison's disease.

Published
2024
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