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Your search keyword '"Pádraigín Harnedy-Rothwell"' showing total 3 results
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3 results on '"Pádraigín Harnedy-Rothwell"'

1. Purification and characterization of multifunctional peptides with in situ insulinotropic and antioxidative activity from a blue whiting (Micromesistius poutassou) protein hydrolysate

Author

Niloofar Shekoohi, Pádraigín Harnedy-Rothwell, Shaun Sharkey, Ryan Lafferty, Neda Khatib, Finbarr O' Harte, and Richard J. FitzGerald

Subjects
Bioactive peptides, Blue whiting, Glycaemic management, Antioxidant, Caco-2, HepG2, Nutrition. Foods and food supply, TX341-641
Abstract

Two blue whiting protein hydrolysates (BWPHs) with potent in situ and in vitro antidiabetic and antioxidant activities were fractionated. Potent fractions were analysed using LC-MS/MS. Peptides VPVE and IPQD exhibited potent in situ DPP-IV inhibitory activity (Caco-2 cells) with IC50 values of 88.79 ± 5.40 and 91.12 ± 19.73 µM, respectively. Significant decreases in ROS production observed (HepG2 cells) with MPKKE, GPAG and MPAH. MPAH and LPDDL significantly (p

Published
2024
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2. Twice daily oral administration of Palmaria palmata protein hydrolysate reduces food intake in streptozotocin induced diabetic mice, improving glycaemic control and lipid profiles

Author

Christopher M. McLaughlin, Shaun J. Sharkey, Pádraigín Harnedy-Rothwell, Vadivel Parthsarathy, Philip J. Allsopp, Emeir M. McSorley, Richard J. FitzGerald, and Finbarr P.M. O'Harte

Subjects
Streptozotocin induced diabetes, Insulin secretion, Palmaria palmata, Protein hydrolysate, GLP-1, Blood glucose, Nutrition. Foods and food supply, TX341-641
Abstract

This study investigated the antihyperglycaemic effectiveness of an oral Palmaria palmata protein hydrolysate (PPPH), versus metformin, upon metabolic control in streptozotocin (STZ)-induced diabetic mice. Mice were administered PPPH (50 mg/kg bodyweight) or metformin (200 mg/kg bodyweight) by oral gavage twice-daily for 18 days. Blood glucose and plasma insulin were measured every third day. PPPH caused a significant reduction in blood glucose (p

Published
2020
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