853 results on '"Oyama, H."'
Search Results
2. Experimental and Clinical Performance of Long-Term Cannulas for Mechanical Circulatory Assistance
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Oyama, H. T. T., Bacht, S., Mazzetto, M., Caneo, L. F., Jatene, M. B., Jatene, F. B., Cestari, I. A., Magjarevic, Ratko, Series Editor, Ładyżyński, Piotr, Associate Editor, Ibrahim, Fatimah, Associate Editor, Lackovic, Igor, Associate Editor, Rock, Emilio Sacristan, Associate Editor, Bastos-Filho, Teodiano Freire, editor, de Oliveira Caldeira, Eliete Maria, editor, and Frizera-Neto, Anselmo, editor
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- 2022
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3. Mechanical and Morphological Analysis of Electrospun Poly(ε-Caprolactone) and Reduced Graphene Oxide Scaffolds for Tissue Engineering
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Maizato, M. J. S., Oyama, H. T. T., Kakoi, A. A. Y., Cestari, I. A., Magjarevic, Ratko, Series Editor, Ładyżyński, Piotr, Associate Editor, Ibrahim, Fatimah, Associate Editor, Lackovic, Igor, Associate Editor, Rock, Emilio Sacristan, Associate Editor, Bastos-Filho, Teodiano Freire, editor, de Oliveira Caldeira, Eliete Maria, editor, and Frizera-Neto, Anselmo, editor
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- 2022
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4. Experimental and Clinical Performance of Long-Term Cannulas for Mechanical Circulatory Assistance
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Oyama, H. T. T., primary, Bacht, S., additional, Mazzetto, M., additional, Caneo, L. F., additional, Jatene, M. B., additional, Jatene, F. B., additional, and Cestari, I. A., additional
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- 2022
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5. Mechanical and Morphological Analysis of Electrospun Poly(ε-Caprolactone) and Reduced Graphene Oxide Scaffolds for Tissue Engineering
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Maizato, M. J. S., primary, Oyama, H. T. T., additional, Kakoi, A. A. Y., additional, and Cestari, I. A., additional
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- 2022
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6. Design and Hydrodynamic Performance of a Pediatric Pulsatile Pump
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Cestari, I. A., Mazzetto, M., Oyama, H. T. T., Bacht, S., Jatene, M. B., Cestari, I. N., Jatene, F. B., Magjarevic, Ratko, Series Editor, Ładyżyński, Piotr, Associate Editor, Ibrahim, Fatimah, Associate Editor, Lackovic, Igor, Associate Editor, Rock, Emilio Sacristan, Associate Editor, Costa-Felix, Rodrigo, editor, Machado, João Carlos, editor, and Alvarenga, André Victor, editor
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- 2019
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7. Difference in Pain and Discomfort of Comparable Wrist Movements Induced by Magnetic or Electrical Stimulation for Peripheral Nerves in the Dorsal Forearm
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Abe G, Oyama H, Liao Z, Honda K, Yashima K, Asao A, and Izumi SI
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peripheral magnetic stimulation ,peripheral electrical stimulation ,pain ,discomfort ,integrated range of wrist movement ,Medical technology ,R855-855.5 - Abstract
Genji Abe,1,2,* Hideki Oyama,3,* Zhenyi Liao,1 Keita Honda,1 Kenji Yashima,4 Akihiko Asao,5 Shin-Ichi Izumi1,3 1Department of Physical Medicine and Rehabilitation, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan; 2Department of Rehabilitation, Faculty of Medical Science and Welfare, Tohoku Bunka Gakuen University, Sendai, Miyagi, Japan; 3Department of Physical Medicine and Rehabilitation, Graduate School of Biomedical Engineering, Tohoku University, Sendai, Miyagi, Japan; 4IFG Corporation, Sendai, Miyagi, Japan; 5Department of Occupational Therapy, Niigata University of Health and Welfare, Niigata, Japan*These author contributed equally to this workCorrespondence: Genji AbeTohoku University Graduate School of Medicine, Sendai-shi, Miyagi, JapanTel +81-22-717-7338Fax +81-22-717-7340Email genji.abe@gmail.comPurpose: Both repetitive peripheral magnetic stimulation (rPMS) and transcutaneous electrical current stimulation (TES) could elicit the limb movements; it is still unclear how subjective sensation is changed according to the amount of limb movements. We investigated the pain and discomfort induced by newly developed rPMS and TES of peripheral nerves in the dorsal forearm.Methods: The subjects were 12 healthy adults. The stimulus site was the right dorsal forearm; thus, when stimulated, wrist dorsiflexion was induced. The rPMS was delivered by the new stimulator, Pathleader at 10 stimulus intensity levels, and TES intensity was in 1-mA increments. The duration of each stimulation was 2 s. The analysis parameters were subjective pain and discomfort, measured by a numerical rating scale. The rating scale at corresponding levels of integrated range of movement (iROM) induced by rPMS or TES was compared. The subjective values were analyzed by two-way repeated measures ANOVA with the stimulus conditions (rPMS, TES) and the seven levels of iROM (20– 140 ºs).Results: In the rPMS experiments, stimuli were administered to all subjects at all stimulus intensities. In the TES experiments, none of the subjects dropped out between 1 and 16 mA, but there were dropouts at each of the intensities as follows: 1 subject at 17 mA, 20 mA, 22 mA, 23 mA, 27 mA, 29 mA and 2 subjects at 21 mA, 24 mA, 26 mA. The main effects of the stimulus conditions and iROM were significant for pain and discomfort. Post hoc analysis demonstrated that pain and discomfort in rPMS were significantly lower compared to TES when the iROM was above 60 ºs and 80 ºs, respectively.Conclusion: New rPMS stimulator, Pathleader, caused less pain and discomfort than TES, but this was only evident when comparatively large joint movements occurred.Keywords: peripheral magnetic stimulation, peripheral electrical stimulation, pain, discomfort, integrated range of wrist movement
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- 2020
8. Sodium salt hydrate crystals of nonsteroidal anti-inflammatory drugs: structure and solid-state dehydration transition relationship
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Oyama, H., primary and Uekusa, H., additional
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- 2023
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9. Design and Hydrodynamic Performance of a Pediatric Pulsatile Pump
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Cestari, I. A., primary, Mazzetto, M., additional, Oyama, H. T. T., additional, Bacht, S., additional, Jatene, M. B., additional, Cestari, I. N., additional, and Jatene, F. B., additional
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- 2019
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10. Effects of duloxetine on pain and walking distance in neuropathic pain models via modulation of the spinal monoamine system
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Minami, K., Tamano, R., Kasai, E., Oyama, H., Hasegawa, M., Shinohara, S., and Asaki, T.
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- 2018
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11. # 1311 Defining the distal margin of rectal cancer for surgical planning.
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SATO, S, YATSUOKA, T, UMEMOTO, T, SHINMURA, K, KIJIMA, K, HARADA, Y, SEKINE, R, SHIOZAWA, T, OYAMA, H, and TANAKA, J
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- 2015
12. Direct flux noise measurement of YBa2Cu3O7-δ Grain Boundary Junction
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Hirano, S., Oyama, H., Matsuda, M., Morooka, T., Nakayama, S., Kuriki, S., Yamashita, Tsutomu, editor, and Tanabe, Kei-ichi, editor
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- 2000
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13. Effect of Glycerol on Blood Flow Distribution in Tumoral and Peritumoral Brain Tissue
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Niwa, Masahiro, Oyama, H., Furuse, M., Takada, S., Kawai, T., Ishikawa, Y., Kuchiwaki, H., Inao, S., Ichimi, K., Shibayama, M., Reulen, H.-J., editor, Steiger, H.-J., editor, James, Hector E., editor, Marshall, Lawrence F., editor, Raulen, Hans J., editor, Baethmann, Alexander, editor, Marmarou, Anthony, editor, Ito, Umeo, editor, Hoff, Julian T., editor, Kuroiwa, Toshihiko, editor, and Czernicki, Zbigniew, editor
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- 1997
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14. Gadolinium-Neutron Capture Reactions: A Radiobiological Assay
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Akine, Y., Tokita, N., Matsumoto, T., Oyama, H., Aizawa, O., Allen, Barry J., editor, Moore, Douglas E., editor, and Harrington, Baiba V., editor
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- 1992
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15. Microstructure and fatigue properties of double-sided friction stir welded Ti-4.5Al-2.5Cr-1.2Fe-0.1C alloy plate for aerospace applications
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Nakai, M., primary, Niinomi, M., additional, Hieda, J., additional, Cho, K., additional, Komine, K., additional, Fujii, H., additional, Morisada, Y., additional, Ito, Y., additional, Konno, T., additional, Itsumi, Y., additional, Oyama, H., additional, and Abe, W., additional
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- 2013
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16. Role of Graphene Oxide on the Mechanical Behaviour of Polycarbonate-Urethane/Graphene Oxide Composites
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Maestrelli, L. M. D., primary, Oyama, H. T. T., additional, Muñoz, P. A. R., additional, Cestari, I. A., additional, and Fechine, G. J. M., additional
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- 2021
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17. Alterations of body mass index and body composition in atomic bomb survivors
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Tatsukawa, Y, Misumi, M, Yamada, M, Masunari, N, Oyama, H, Nakanishi, S, Fukunaga, M, and Fujiwara, S
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- 2013
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18. Discriminative determination of hydrogen gas formed from tandem CO 2 reforming and shift reaction by isotope labeling followed by cryogenic gas chromatography
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Ishida, Y., Taki, H., Oyama, H., Kitagawa, K., and Matsumoto, K.
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- 2006
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19. High-Tc SQUID magnetometers for use in moderate magnetically-shielded room
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Matsuda, M., Ono, S., Kato, K., Matsuura, T., Oyama, H., Hayashi, A., Hirano, S., Kuriki, S., and Yokosawa, K.
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Magnetometer -- Research ,Superconducting quantum interference devices -- Research ,Superconductivity -- Research ,Business ,Electronics ,Electronics and electrical industries - Abstract
Research describing the magnetic properties of high temperature superconducting quantum interference device magnetometers is presented. In particular differing designs are investigated for biomagnetic applications.
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- 2001
20. Effect of flux dam on low-frequency noise in high-Tc SQUID magnetometers
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Oyama, H., Kuriki, S., and Matsuda, M.
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Magnetometer -- Research ,Superconducting quantum interference devices -- Research ,Superconductivity -- Research ,Business ,Electronics ,Electronics and electrical industries - Abstract
Research describing the behavior of high temperature, superconducting quantum interference device magnetometers subject to magnetic fields is presented. In particular the effects on noise of slots in the flux dam is investigated.
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- 2001
21. Direct detection of vortex motion in high-Tc grain boundary junctions
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Hirano, S., Oyama, H., Matsuda, M., Morooka, T., Nakayama, S., and Kuriki, S.
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Superconducting quantum interference devices -- Usage ,Vortex-motion -- Observations ,Business ,Electronics ,Electronics and electrical industries - Abstract
Measurements of flux from vortices in a field cooled wide bicrystal Yba2Cu3O7 grain boundary junction were undertaken using a superconducting thin film coils and Nb based SQUID.
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- 2001
22. Transmission line high-Tc de-SQUIDs
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Kuriki, S., Oyama, H., Maruyama, E., Hayashi, A., Hirano, S., Suzuki, D., and Koyanagi, M.
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High temperature superconductors -- Research ,Magnetometer -- Research ,Strip transmission lines -- Research ,Yttrium barium copper oxides -- Research ,Business ,Electronics ,Electronics and electrical industries - Abstract
A study was conducted to examine the I-V characteristics of high-temperature yttrium barium copper oxide (YBCO) dc superconducting quantum interference devises (SQUIDs) which were placed within the hole of the pickup coil of a direct coupling magnetometer. Experimental results show that the fabricated YBCO dc SQUIDs have a transmission geometry similar to thin parallel strips and have a wide slit between them. On the other hand, it was noted that the magnetometer has a high field sensitivity of 100 ft/Hz(super 1/2).
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- 1999
23. Recoil-ion momentum spectroscopy of multiply charged argon ions produced by intense (∼1016 W cm−2) laser light
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Shimada, H., Nakai, Y., Oyama, H., Ando, K, Kambara, T., Hatakeyama, A., and Yamazaki, Y.
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- 2005
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24. X-rays emitted from N ions transmitted through a thin Ni microcapillary target
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Iwai, Y., Kanai, Y., Nakai, Y., Ikeda, T., Hoshino, M., Oyama, H., Ando, K., Masuda, H., Nishio, K., Torii, H.A., Komaki, K., and Yamazaki, Y.
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- 2005
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25. Detection of Interstitial Pneumonitis in Patients with Rheumatoid Arthritis by Measuring Circulating Levels of KL-6, a Human MUC1 Mucin
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Oyama, T., Kohno, N., Yokoyama, A., Hirasawa, Y., Hiwada, K., Oyama, H., Okuda, Y., and Takasugi, K.
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- 1997
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26. Characterization of polymer-coated silica particles by microelectrophoresis
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Sprycha, R., Oyama, H. T., Zelenev, A., and Matijević, E.
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- 1995
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27. Abstracts for the Tenth International Conference on Brain Tumour Research and Therapy: Stalheim Hotel, Voss, Norway, September 6–9, 1993
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Abrahamsen, Tore G., Wesenberg, Finn, Mørk, Sverre, Allen, Jeffrey, Hayes, Roberta, DaRosso, Robert, Nirenberg, Anita, Ali-Osman, Francis, Akande, Nike, Amberger, V., Seulberger, H., Paganetti, P. A., Schwab, M. E., Schwab, M. E., Arita N., Ohnishi T., Hiraga S., Yamamoto H., Taki T., Izumoto S., Higuchi M., Hayakawa T., Kusakabe M., Sakakura T., Baldwin, N. G., Rice, C. D., Merchant, R. E., Ashmore, Sally M., Darling, J. L., Bailey, C. C., Balmaceda C., Diez B., Villablanca J., Walker R., Finlay J., Bergenheim, A. Tommy, Hartman, Magdalena, Bergh, Jonas, Ridderheim, PerÅke, Henriksson, Roger, Berens, Michael E., Rief, Monique D., Giese, Alf, Zackrisson, Björn, Elfversson, Jörgen, Bernstein, Mark, Cabantog, Alberto, Glen, Jennifer, Mikulis, David, Bjerkvig, Rolf, Pedersen, Paal-Henning, Mathisen, Berit, Mahesparan, Rupavathana, Haugland, Hans Kristian, Bernstein, Mark, Laperriere, Normand, Thomason, Cindy, Leung, Phil, Bobola M. S., Berger M. S., Silber J. R., Bongcam-Rudloff, Erik, Wang, Jia-Lun, Nistér, Monica, Westermark, Bengt, Brem, Steven, Breslow, Gary, Ho, Jason, Gately, Stephen, Takano, Shingo, Ward, William, Brada, M., Laing, R., Warrington, J., Brem, Steven, Engelhard, Herbert, Takano, Shingo, Gately, Stephen, Brem, Steven, Landau, Barry, Kwaan, Hau, Verrusio, Elaine, Buckner, J. C., Cascino, T. L., Schomberg, P. S., O'Fallon, J. R., Dinapoli, R. P., Burch, P. A., Shaw, E. G., Broaddus, William C., Hager-Loudon, Kathryn, Merchant, Randall E., Loudon, William, Couldwell, William T., Jiang, Jack B., Burns, David, Couldwell, William T., Weiss, Martin H., Apuzzo, Michael L. J., Desbaillets I., Tada M., de Tribolet N., Van Meir, E., Davis, R. L., Onda, K., Prados, M. D., Dolan, M. Eileen, Fleig, Matthew J., Friedman, Henry S., Ekstrand, A. Jonas, Longo, Nicola, James, C. David, Chou, D., Wijnhoven, B., Bellinzona, M., Nakagawa, M., Feuerstein B. G., Basu H. S., Dolan M. E., Bergeron C., Pellarm M., Deen D. F., Marton L. J., Finlay, Jonathan, Fulton D. S., Urtasun R. C., Giese, Alf, Scheck, Adrienne C., Geddes, J., Vowles, G. M., Ashmore, S. M., Gillespie, G. Y., Goldman, C. K., Tucker, M. T., Lyon, E., Tsai, J. -C., Gobbel, G. T., Chan, P. H., Greenberg, Hairy S., Chandler, W. F., Ensminger, W. D., Junck, L., Sandler, H., Bromberg, J., McKeever, P., Gonzalez G. G., Sarkar A., Basu H., Feuerstein B. G., Deen D. F., Haugland, Kr., Tysnes, Ole-Bjørn, Hiraga, Shoju, Arita, Norio, Ohnishi, Takanori, Taki, Takuyu, Yamamoto, Hiroshi, Higuchi, Masahide, Hayakawa, Toru, Isern, Erik, Unsgaard, Geirmund, Marthinsen, Anne Beate Langeland, Strickert, Trond, Helseth, Eirik, Hochberg F., Cosgrove R., Valenzuela R., Pardo F., Zervas N., Jenkins, Robert B., Ritland, Steven R., Hailing, Kevin C., Thibodeau, Stephen N., Juillerat L., Darekar P., Janzer R. C., Hamou M. F., Kato, Tsutomu, Sawamura, Yutaka, Tada, Mitsuhiro, Sakuma, Shirou, Sudo, Masako, Abe, Hiroshi, Kallio M., Leppää J., Nikula T., Nikkinen P., Gylling H., Färkkilä M., Hiltunen J., Jääskeläinen J., Liewendahl K., Keles, G. Evren, Berger, Mitchel S., Deliganis, Anna, Kellie S. J., De Graaf S. S. N., Bloemhof H., Johnston I., Uges D. D. R., Besser M., Chaseling R. W., Ouvrier R. A., Kitchen, N. D., Hughes, S., Beaney, R., Thomas, D. G. T., Kim D. H., Maeda T., Mohapatra G., Park S., Waldman F. W., Gray J. W., Koala, D., Silber, J., Berger, M., Krauseneck P., Müller B., Strik H., Warmuth-Metz M., Kuratsu, Jun-ichi, Takeshima, Hideo, Ushio, Yukitaka, Kretschmar, C., Grodman, H., Linggood, R., Kyritsis, A. P., Bondy, M., Cunningham, J., Xiao, M., Levin, V., Leeds, N., Bruner, J., Yung, W. K. A., Saya, H., Lampson, L. A., Nichols, M. R., Lampson, M. A., Dunne, A. D., Li, Hong, Hamou, Marie-France, Jaufeerally, Rehana, Diserens, Annie-Claire, Van Meir, Erwin, de Tribolet, Nicolas, Levin, V. A., Maor, M., Sawaya, R., Leavens, M., Woo, S., Thall, P., Gleason, M. J., Liang, Bertrand C., Ross, D. A., Meltzer, P. S., Trent, J. M., Greenberg, H. S., Lillehei K. O., Kong Q., DeMasters B. K., Withrow S. J., Macdonald D. R., Cairncross J. G., Ludwin S., Lee D., Cascino T., Buckner J., Dropcho E., Fulton D., Stewart D., Schold C., Wainman N., Eisenhauer E., Kirby S., Fisher B. J., Magrassi, L., Butti, G., Pezzotta, S., Milanesi∘, G., Matsutani, Masao, Marienhagen, Kirsten, Laerum, Ole Didrik, Baldwin, N. G., Merzak, Abderrahim, Koocheckpour, Shahriar, Roxanis, Yannis, Pilktngton, Geoffrey J., Nagai, Masakatsu, Watanabe, Kunihiko, Narita, Jun-ichi, Hagiwara, Hideaki, Noble, Mark, Nomura, K., Oyama, H., Motoo, M., Shibui, S., Tokuue, K., Akine, Y., Ohnishi, T., Arita, N., Hiraga, S., Hayakawa, T., Nygaard, Svein J. Tjoflaat, Tysnes, Ole-Bjørn, Pardo, F. S., Hsu, D. W., Hedley-Whyte, E. T., Efird, J., Schmidt, E. V., Marienhagen, Paal-Henning Pedersenl Kirsten, Pilkington, Geoffrey J., Clarke, Tracey M., Yu, Hui Tian, Rogers, Joan P., Stern, Robert, Phuphanich, Surasak, Greenberg, Harvey, Murtagh, R., Viloria, Jesus, Ransohoff, Joseph, Martin, Kimberly, Hatva, V. Erika, Rao, Jasti S., Mohanam, S., Rempel, Sandra A., Schwechheimer, Karl, Davis, Richard L., Cavenee, Webster K., Rosenblum, Mark L., Reifenberger, Guido, Liu, Lu, Ichimura, Koichi, Schmidt, Esther E., Collins, V. Peter, Revesz T., Scaravilli F., Cockburn H., Thomas D. G. T., Rice, C. D., Biron, R. T., Merchant, R. E., McKerrow, James, Sloane, Bonnie, Mikkelsen, Tom, Roosen, Norbert, Coopersmith, Peter, Smith, Robert, Rooprai, Harcharan Kaur, Maidment, Steven, Rucklidge, Garry, Volovsek, Anton, Rutka J. T., Smith S. L., Matsuzawa K., Sankar, A. A., Darling, J. L., Williams, S. R., Fukuyama K., Marton L. J., Ikeda, Jun, Selker, R. G., Vertosick, F. T., Goldenberg, M. T., Bindal, R., Diez B., Taratuto A., Picco P., Monges J., Martinez M., Pacheco G., Gamboni M., Schultz M., Silber J. R., Mueller B. A., Ewers T. G., Berger M. S., Shiraishi, T., Tabuchi, K., Nakagawa, S., Kihara, S., Stewart, D. J., Eapen, L., Agboola, O., Popovic, P., Goel, R., Raaphorst, P., Wong, P. T. T., Shimokawa, S., Oh-uchida, M., Hori, K., Markert C., Pflughaupt K. -W., Tada M., Diserens A. -C., Jauferrally R., Desbaillets I., Hamou M. -F., de Tribolet N., Takeshima H., Mochizuki H., Clifford J. L., Nishi T., Levin V. A., Lotan R., Saya H., Terzis, A. J. A., Arnold, H., Laerum, O. D., Bjerkvig, R., Taratuto A. L., Sevlever G., Diaz D., Di Tella M., Cuccia V., Pomata H., Gallo G., Dietze, A., Knopp, U., Thomas, R., Brada, M., Carnochan, P., Flux, G., Kitchen, N., Thomas, D., Zalutsky, M., Bigner, D., Tofilon, Philip, Borchardt, Paul, Torp, Sverre H., Dalen, Are, Tohyama, Takashi, Kubo, Osami, Takakura, Kintomo, Lee, Virginia M. -Y., Trojanowski, John Q., Nygaard, Svein, Urtasun, R. C., Parliament, M. B., McEwan, A. J., Mannan, R. H., Weibe, L. I., Unsgårp, G., Sonnewald, U., Gribbestad, I., Isern, E., Petersen, S. B., Wang J., Delgado D. A., Warr, Tracy J., Sheer, Denise, Gorman, Pat, Yamaguchi, F., Westphal, M., Anker, L., Hamel, W., Lücke, M., Shepard, M., Kleihues, P., Herrmann, H. D., Yung, W. K. Alfred, Taylor, Scott, and Steck, Peter A.
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- 1993
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28. Sedolisin and friends – from the sequences through structures to biological significance
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Wlodawer, A., Li, M., Gustchina, A., Oyama, H., Oda, K., Nakayama, T., and Dunn, B. M.
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- 2004
29. An experimental study of gas-hydrate formation by measuring viscosity and infrared spectra
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Oyama, H, Ebinuma, T, Shimada, W, Takeya, S, Nagao, J, Uchida, T, and Narita, H
- Published
- 2003
30. The continuing saga of the Si-like intercombination lines in highly charged ions, Si-like rhodium
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Huang, M., Hutton, R., Zou, Y., Ando, K., and Oyama, H.
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- 2003
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31. High-resolution soft X-ray spectroscopy of slow highly charged ions transmitted through a microcapillary target
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Iwai, Y., Kanai, Y., Nakai, Y., Ikeda, T., Oyama, H., Ando, K., Masuda, H., Nishio, K., Nakao, M., Torii, H.A., Komaki, K., and Yamazaki, Y.
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- 2003
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32. In vitro affinity maturation of anti-cortisol antibodies to develop sensitive immunoassays
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Oyama, H., primary, Morita, I., additional, Kiguchi, Y., additional, and Kobayashi, N., additional
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- 2019
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33. Generation of monoclonal antibodies for on-site analysis of psilocin and psilocybin in hallucinogenic mushrooms
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Morita, I., primary, Oyama, H., additional, Tanaka, R., additional, Kikura-Hanajiri, R., additional, and Kobayashi, N., additional
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- 2019
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34. High-resolution soft X-ray spectroscopy of 2.3 keV/u N 7+ ions through a microcapillary target
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Iwai, Y, Murakoshi, D, Kanai, Y, Oyama, H, Ando, K, Masuda, H, Nishio, K, Nakao, M, Tamamura, T, Komaki, K, and Yamazaki, Y
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- 2002
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35. Haptic reproduction and interactive visualization of a beating heart for cardiovascular surgery simulation
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Nakao, M, Oyama, H, Komori, M, Matsuda, T, Sakaguchi, G, Komeda, M, and Takahashi, T
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- 2002
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36. Preliminary ligation of vascular pedicles in male radical cystectomy
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FUKUI, I., IZUTANI, T., YONESE, J., OYAMA, H., and KAWAI, T.
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- 1997
37. Edoxaban versus warfarin in patients with atrial fibrillation
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Robert P. Giugliano, Christian T. Ruff, Eugene Braunwald, Sabina A. Murphy, Stephen D. Wiviott, Jonathan L. Halperin, Albert L. Waldo, Michael D. Ezekowitz, Jeffrey I. Weitz, Jind?ich ?pinar, Witold Ruzyllo, Mikhail Ruda, Yukihiro Koretsune, Joshua Betcher, Minggao Shi, Laura T. Grip, Shirali P. Patel, Indravadan Patel, James J. Hanyok, Michele Mercuri, Elliott M. Antman, Braunwald E, Antman EM, Giugliano RP, Ruff CT, Morin SE, Hoffman EB, Murphy SA, Deenadayalu N, Grip L, Mercuri M, Lanz H, Patel I, Curt V, Duggal A, Hanyok J, Davé J, Morgan D, Choi Y, Shi M, Jin J, Xie J, Crerand W, Kappelhof J, Maxwell W, Skinner M, Patel S, Betcher J, Selicato G, Otto C. 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Pazier P, Riofrio K, Braun D, Robinson J, Cherrico M, Roehll W, Hollihan P, Rosado, Barnhorst M, Rosado J, Bamhorst M, Rosen R, Martin C, Ross S, Freeman R, Ruoff G, Nelson T, Sacco J, Ball E, Samal A, Schomburg J, Sandberg J, Lafave J, Savin V, Clifton R, Schaefer S, Fekete A, Schneider R, Schneider W, Schulman D, Mercer S, Seals A, Ullig T, Holt A, Seide H, Mather N, Shah G, Witt P, Shalaby A, Seese M, Shanes J, Fleets J, Shaoulian E, Hren A, Sheikh K, Hengerer T, Shih H, Browning J, Shoukfeh M, Stephenson L, Siler T, Champagne M, Simpson P, Meyer R, Singh N, Turner K, Singh V, Nelson M, Skierka R, Hughes B, Keene R, Smith R, Hodnett P, Spangenthal S, Thomason L, Sperling M, Vasquez E, Spivack E, McCartney P, Staniloae C, Liu M, Steljes A, Cox C, Struble R, Vittitow T, Suresh D, Frost J, Swerchowsky V, Freemyer D, Szulawski I, Herwehe S, Tahirkheli N, Springer K, Takata T, Bruton T, Talano J, Leo L, Tami L, Corchado D, Tatarko M, Swauger M, Tawney K, Dastoli K, Teague S, Young K, Tee H, Mitchell T, Teixeira J, Southam D, Torres M, Tucker P, Salas L, Updegrove J, Hanna K, Val Mejias J, Harrelson KG, Vemireddy D, Cardoza T, Verma S, Parsons T, Vicari R, Warren K, Vijay N, Washam M, Vossler M, Kilcup S, Walsh R, Renaud K, Ward S, Locklear T, Waxman F, Sanchez G, Weiss R, St Laurent B, Westcott J, Williams D, Gibson C, Williams R, Dowling C, Willis J, VonGerichten S, Wood K, Capasso Gulve E, Worley S, Pointer S, Yarows S, Sheehan T, Yasin M, Yi J, Dongas B, Yousuf K, Zakhary B, Curtis S, Zeig S, Mason T, Zellner C, Harden M, Roper E, Waseem M, Grammer M., PERRONE FILARDI, PASQUALE, Cardiovascular Division (SZG), Brigham and Women's Hospital [Boston], Mount Sinai Medical Center, Icahn School of Medicine at Mount Sinai [New York] (MSSM), University Hospitals Case Medical Center (CLEVELAND - UHCMC), University Hospitals Case Medical Center, Jefferson Medical College (JMC), Thomas Jefferson University Hospitals, Thrombosis and Atherosclerosis Research Institute (TARI), McMaster University [Hamilton, Ontario], University Hospital Brno, Institute of Cardiology (WARSAW - Cardiology), Institute of Cardiology, Cardiology Research Center (MOSCOU - CRC), Cardiology Research Center, National Hopital Organization (OSAKA - NHO), Osaka National Hospital, Université de Brest (UBO), Centre d'Investigation Clinique (CIC - Brest), Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM), Graduate School, Endocrinology, ACS - Amsterdam Cardiovascular Sciences, Cardiology, Nursing, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, General Internal Medicine, Giugliano, Rp, Ruff, Ct, Braunwald, E, Murphy, Sa, Wiviott, Sd, Halperin, Jl, Waldo, Al, Ezekowitz, Md, Weitz, Ji, Špinar, J, Ruzyllo, W, Ruda, M, Koretsune, Y, Betcher, J, Shi, M, Grip, Lt, Patel, Sp, Patel, I, Hanyok, Jj, Mercuri, M, Antman, Em, Comi, Giancarlo, ENGAGE AF TIMI 48, Investigators, Robert P., Giugliano, Christian T., Ruff, Eugene, Braunwald, Sabina A., Murphy, Stephen D., Wiviott, Jonathan L., Halperin, Albert L., Waldo, Michael D., Ezekowitz, Jeffrey I., Weitz, Jind?ich, ?pinar, Witold, Ruzyllo, Mikhail, Ruda, Yukihiro, Koretsune, Joshua, Betcher, Minggao, Shi, Laura T., Grip, Shirali P., Patel, Indravadan, Patel, James J., Hanyok, Michele, Mercuri, Elliott M., Antman, Morin, Se, Hoffman, Eb, Deenadayalu, N, Grip, L, Lanz, H, Curt, V, Duggal, A, Hanyok, J, Davé, J, Morgan, D, Choi, Y, Jin, J, Xie, J, Crerand, W, Kappelhof, J, Maxwell, W, Skinner, M, Patel, S, Selicato, G, Otto C., Jr, Reissner, C, Smith, K, Ostroske, J, Ron, A, Giugliano, R, Connolly, S, Camm, J, Ezekowitz, M, Halperin, J, Waldo, A, Paolasso, E, Aylward, P, Heidbuchel, H, Nicolau, Jc, Goudev, A, Roy, D, Weitz, J, Corbalán, R, Yang, Y, Botero, R, Bergovec, M, Ŝpinar, J, Grande, P, Hassager, C, Voitk, J, Huikuri, H, Nieminen, M, Blanc, Jj, Leheuzey, Jy, Mitrovic, V, Alexopoulos, D, Sotomora, G, Kiss, R, Somaraju, B, Lewis, B, Merlini, P, Metra, M, Yamashita, T, García 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Jardula, M, Andresen, T, Johnson, F, Phillips, T, Jones, R, Hughett, G, Jovin, I, Nichols, M, Judson, P, Royes, A, Kahn, B, Coombs, V, Kai, W, Dugal, J, Kandath, D, Kostedt, G, Kaplan, K, Cook, S, Kapoor, A, Ruggiero, M, Karunaratne, H, Behm, K, Kastelic, R, Davis, C, Keller, R, Keller, J, Kerkering, M, Bartholomaus, D, Kersh, R, Buhler, A, Kesselbrenner, M, Dicorcia, L, Khan, B, Binns, M, Khan, M, Khan, G, Kindman, L, Averett, P, Korpas, D, Godfrey, C, Kotha, P, Sanchez, E, Kozlowski, J, Watts, S, Krichmar, P, Marquez, D, Laliotis, A, Jauregui, V, Lambert, C, Coyle, G, Landau, C, Ferguson, D, Lang, J, Simmons, T, Langevin, E, Faucett, S, Ledbetter, L, Royse, H, Lentz, M, Smith, D, Lesser, M, Hartley, L, Lewis, D, Bonds, C, Lillestol, M, Miller, D, Ling, L, Murphy, R, Littlefield, R, Wofford, E, Lomnitz, D, Lone, B, Davids, M, Looby, R, Ault, S, Lui, H, Wright, H, Lurie, M, Edelstein, J, Macomber, J, Bush, D, Magee, A, Doctor, A, Mainigi, S, Lisiecki, B, Makam, S, Casas, R, Mandviwala, M, Marar, I, Rabadi Marar, D, Marenberg, M, Bedenko, E, Massin, E, Hicks, T, Mccartney, M, Stubbs, L, Mcgarvey, J, Schwarz, L, Mcguire, K, Mckenzie, M, Rodkey, K, Mcknight, T, Paul, J, Mclaurin, B, Lack, A, Mega, J, Marti, J, Meholick, A, Skinner, J, Mehrle, A, Wall, J, Mendelson, R, Cervellione, K, Mercado, A, Cajulis, C, Michlin, B, Romero Colon, J, Milas, J, Sanders, D, Miller, R, Sanchez, S, Miller, S, Gryczan, J, Mody, F, Strugatsky, S, Moran, J, Garner, S, Morledge, J, Bowman, B, Mouhaffel, A, Parrott, N, Mounsey, P, Schuler, C, Mowdy, M, Todd, S, Mullen, P, Raziano, S, Murphy, A, Oehmann, V, Nadar, V, Parker, A, Naidu, J, West, M, Nallasivan, M, Goza, J, Nguyen, T, Nomanee, S, Nielsen, R, Wilmot, M, Oberoi, M, Thakkar, N, Oppenheimer, K, Mccormick, J, Orchard, R, Garcia, L, Osborne, J, Gonzalez, M, Oza, S, Joseph, L, Patnam, S, Dennison, K, Pavon, H, Gorry, N, Pearlstein, R, Montayne, S, Pentz, W, Duncan, D, Peters, P, Chacon, L, Petruzziello, F, Morlando, F, Pettis, K, Brown, 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Grammer, M.
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Male ,Pyridines ,[SDV]Life Sciences [q-bio] ,Embolism ,Kaplan-Meier Estimate ,030204 cardiovascular system & hematology ,chemistry.chemical_compound ,0302 clinical medicine ,Edoxaban ,Atrial Fibrillation ,MESH: Double-Blind Method ,030212 general & internal medicine ,MESH: Warfarin ,Stroke ,MESH: Aged ,MESH: Middle Aged ,Cardiovascular diseases [NCEBP 14] ,Hazard ratio ,General Medicine ,MESH: Follow-Up Studies ,Middle Aged ,3. Good health ,MESH: Atrial Fibrillation ,Cardiovascular Diseases ,Anesthesia ,Cardiology ,Female ,Adult ,Aged ,Anticoagulants ,Double-Blind Method ,Follow-Up Studies ,Hemorrhage ,Humans ,Thiazoles ,Warfarin ,MESH: Hemorrhage ,Andexanet alfa ,medicine.drug ,medicine.medical_specialty ,MESH: Enoxaparin ,MESH: Anticoagulants ,MESH: Stroke ,Dabigatran ,03 medical and health sciences ,Internal medicine ,medicine ,MESH: Kaplan-Meier Estimate ,Rivaroxaban ,MESH: Humans ,business.industry ,MESH: Cardiovascular Diseases ,MESH: Adult ,medicine.disease ,Confidence interval ,MESH: Male ,chemistry ,business ,MESH: Female ,MESH: Embolism - Abstract
Contains fulltext : 125374.pdf (Publisher’s version ) (Open Access) BACKGROUND: Edoxaban is a direct oral factor Xa inhibitor with proven antithrombotic effects. The long-term efficacy and safety of edoxaban as compared with warfarin in patients with atrial fibrillation is not known. METHODS: We conducted a randomized, double-blind, double-dummy trial comparing two once-daily regimens of edoxaban with warfarin in 21,105 patients with moderate-to-high-risk atrial fibrillation (median follow-up, 2.8 years). The primary efficacy end point was stroke or systemic embolism. Each edoxaban regimen was tested for noninferiority to warfarin during the treatment period. The principal safety end point was major bleeding. RESULTS: The annualized rate of the primary end point during treatment was 1.50% with warfarin (median time in the therapeutic range, 68.4%), as compared with 1.18% with high-dose edoxaban (hazard ratio, 0.79; 97.5% confidence interval [CI], 0.63 to 0.99; P
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- 2013
38. Direct flux noise measurement of YBCO grain boundary junctions
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Hirano, S., Oyama, H., Morooka, T., Nakayama, S., and Kuriki, S.
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- 2001
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39. Suppression of field-induced low-frequency noise in high- Tc SQUID magnetometers using slotted flux dams
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Oyama, H., Hirano, S., Matsuda, M., and Kuriki, S.
- Published
- 2001
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40. Impact of Spontaneous Extracranial Bleeding Events on Health State Utility in Patients with Atrial Fibrillation: Results from the ENGAGE AF‐TIMI 48 Trial
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Senior, R., Paul, J., McKnight, T., Formoso, I., Saravia Toledo, S., Codutti, O., Sanjurjo, M., Bowen, L., Sanchez, A., Alvarez, M., Rodriguez, M., Navarrete, S., Ramos, H., Venturini, C., Prado, A., Fernandez, E., Pozzer, D., Casares, E., Povedano, G., Tommasi, A., Piskorz, D., Verdini, E., Nul, D., Gandur, H., Muntaner, J., Funes, I., Marino, J., Calderon, M., Manuale, O., Carne, M., Mackinnon, I., Raimondi, G., Lotti, J., Shatsky, K., Rodkey, K., Lorente, C., Vignau, S., Llanos, J., Nigro, A., Litvak, B., Iglesias, M., Liniado, G., Belcuore, M., Lanternier, G., Monaco, F., Kevorkian, R., Jure, D., Jure, H., Bianchini, M., Avery, D., Hominal, M., von Wulffen, M., McKenzie, M., Miranda, J., Wright, L., Pye, M., Flint, L., Newby, D., Andrews, A., Goicoechea, R., Huerta, M., Giannaula, R., Eden, M., Giacomi, G., Ceirano, C., Garrido, M., Perlo, D., Garcia Duran, R., Meiller, F., Gant Lopez, J., Zanotti, A., Fuselli, J., Arrieta, M., Femenia, F., Falu, E., Facello, M., Facello, A., Murdoch, D., Helliwell, L., More, R., Isted, C., Maxwell, T., Jones, D., Marazzi, P., McGhee, C., MacLeod, M., Ebano, P., MacCallum, P., Davolos, M., Estol, C., Moreno, V., Dran, R., Cendali, G., D'Amico, A., Bocanera, M., Cuneo, C., Rosell, M., Cuello, J., Morandini, M., Colombo, H., Brown, R., Saa Zarandon, R., Caruso, O., Novas, V., Cartasegna, L., Fracaro, V., Caccavo, A., Saravia, M., Bustamante Labarta, G., Valle, M., Budassi, N., Lip, G., Finlayson, M., Linker, N., McGuire, K., Atkinson, C., Lindsay, S., Ramasamy, V., Lie, F., Dickinson, D., Douglas, H., D'Costa, D., Wilmott, R., Cohen, A., Duff, J., Choy, A., Davies, D., Chapman, O., Dougal, K., Camm, J., Price, R., Blagden, M., Schwarz, L., McGarvey, J., Stubbs, L., McCartney, M., Hicks, T., Massin, E., Bedenko, E., Marenberg, M., Rabadi-Marar, D., Dunn, S., Beeton, I., Smith, S., Aggarwal, R., Marar, I., Hernandez, S., Berli, M., Petrucci, J., Beloscar, J., Caceres, M., Amuchastegui, M., Ameriso, P., Ameriso, S., Garcia, M., Alvarez, C., Reguero, M., Allall, O., Rosales, E., Albisu, J., Ahuad Guerrero, R., Gonzalez, C., Vogelmann, O., Magnuson, Elizabeth A., Cohen, David J., Giugliano, Robert P., Mandviwala, M., Casas, R., Makam, S., Lisiecki, B., Mainigi, S., Doctor, A., Magee, A., Bush, D., Macomber, J., Edelstein, J., Lurie, M., Wright, H., Lui, H., Ault, S., Looby, R., Davids, M., Lone, B., Shah, D., Lomnitz, D., Wofford, E., Littlefield, R., Murphy, R., Ling, L., Miller, D., Lillestol, M., Bonds, C., Lewis, D., Hartley, L., Lesser, M., Smith, D., Lentz, M., Royse, H., Ledbetter, L., Faucett, S., Langevin, E., Simmons, T., Lang, J., Ferguson, D., Landau, C., Coyle, G. 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L., Zhou, S. X., Li, B. G., Zheng, Z. Q., Wang, J. Q., Zhao, X. L., Han, R. J., Zhao, R. P., Kang, H., Zhang, Z., Lin, Y. N., Zhang, H. Q., Qiang, H., Yuan, Z. Y., Li, L. L., Yu, B., Xu, Y. P., Yin, Y. H., Gao, M., Zheng, Y., Zheng, X., Yang, Y. J., Li, A. Y., Yang, K., Liang, Y. Z., Xu, Y. M., Gu, J. Y., Xu, J. H., Li, Y. E., Wu, S. L., Huang, D., Wei, M., Shi, X. J., Wang, G. P., Qi, S. Y., Wang, D. M., Yang, Z. Y., Ma, S. M., Lu, Z. H., Liu, L., Gu, X. J., Liao, D. N., Liu, Y., Li, Z. Q., Liu, B., Li, W. M., Kong, Y. Q., Li, T. F., Liu, H., Li, L., Qu, Z., Jiang, X. J., Qiu, Y., Hong, L., You, Z. G., Hong, K., Zhang, P., Fu, G. S., Feng, C., Dong, Y. G., Zhang, X., Chen, X. P., Xie, X. D., Chen, J. Z., Xu, G. 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Burger, Zimmermann, S., Almeida, M., Boas, F. Villas, Lustosa, E., Sobral Filho, D., Carraro, A., Simoes, M., Vicente, C., Saraiva, J., do Val, R., Sampaio, R., Pagnan, L. Goncalves, dos Santos, F. Rossi, Rodrigues, D., Rodrigues, A., Rocha, M. Rubia, Rodrigues, L., Barros, R., Rocha, J., Leipelt, J., Katz Weiand, L. Reis, Avellar, K., Reis, G., Gozalo, A., Almeida, J. Pimenta, Luiz, R. Osorio, Leaes, P., Morales, K., Sebba Barroso de Souza, W. Kunz, Radaelli, G., Kalil, C., Almeida, A., Kaiser, S., Cury, C., Jorge, J., Pereira, L., Jaeger, C., Ninho, L., Guimaraes, A., Gomes, A., Gomes, M., Pereira, G., Gagliardi, R., Daitz, C., Finimundi, H., Araujo, E., Ferreira, L., Seroqui, M., Saporito, W. Faustino, Morgado, S., Dutra, O., Laimer, R., Duda, N., Pereira, V., De Patta, M., Barroso, D., Costantini, C., Silva, J., Chaves Junior, H., Fleck, N., Brondani, R., Cunha, S., Botelho, R., Sehnem, E., Precoma, D. Bertolim, Ferraz, R. Franchin, Alves da Costa, F. Augusto, Motta, C., Atie, J., de Melo, R. Ferreira, Lotufo, P. Andrade, Coutinho, E., Vincenzo de Paola, A. Amato, Denie, D., Wollaert, B., Beerts, C., Vrolix, M., Mestdagh, I., Vervoort, G., van Welden, J., Vanwelden, J., Derycker, K., Vandekerckhove, Y., Jacobs, C., Mehrle, A., Skinner, J., Meholick, A., Marti, J., Mega, J., Lack, A., Stockman, D., Huyberechts, D., Scavee, C., Clinckemaille, N., Parque, J., Raepers, M., Mairesse, G., Malmendier, D., Herzet, J., Meeusen, K., Heidbuchel, H., Tincani, G., Desfontaines, P., De Bruyne, L., De Tollenaere, M., de Koning, K., De Bleecker, J., Banaeian, F., Capiau, L., O'Shea, V., Szto, G., Perrett, L., Purnell, P., Batta, C., Paul, V., Li, J., McKeirnan, M., Morrison, H., Wright, J., Wright, A., Chung, A., Watkin, R., Gilchrist, M., Venkataraman, A., Lehman, R., Jones, S., Gates, P., Flecknoe-Brown, S., Silver, G., Davis, S., Kay, S., Dart, A., Slattery, A., Crimmins, D., Price-Smith, S., Colquhoun, D., Hoffmann, B., Arstall, M., Paraskevaidis, T., Anderson, C., Morell, Y., Vico, M., Teves, M., Sosa Liprandi, M., Morara, P., Severino, P., Buzzetti, C., Schygiel, P., Walker, M., Turner, W., Bridge, C., Storey, R., Goloboulicz, A., Schmidberg, J., Kennard, S., Sopher, M., McLaurin, B., Young, G., Kwong, Winghan J., Antman, Elliott M., Ruff, Christian T., Wang, J. H., Iriarte, M., Morissette, A., Wang, Kaijun, Li, Haiyan, and Yalcin, R.
- Subjects
Male ,medicine.medical_specialty ,Complications ,Time Factors ,Pyridines ,Health Status ,Embolism ,Hemorrhage ,Arrhythmias ,030204 cardiovascular system & hematology ,03 medical and health sciences ,0302 clinical medicine ,Quality of life ,Risk Factors ,Surveys and Questionnaires ,Internal medicine ,Atrial Fibrillation ,Humans ,Medicine ,In patient ,Prospective Studies ,030212 general & internal medicine ,anticoagulation ,Blood Coagulation ,Original Research ,Aged ,Aged, 80 and over ,Quality and Outcomes ,business.industry ,Anticoagulants ,Atrial fibrillation ,Middle Aged ,bleeding ,medicine.disease ,Stroke ,Thiazoles ,Treatment Outcome ,quality of life ,utility ,Physical therapy ,Cardiology ,Female ,Warfarin ,Gastrointestinal Hemorrhage ,Cardiology and Cardiovascular Medicine ,business ,TIMI ,Health Services and Outcomes Research ,Factor Xa Inhibitors - Abstract
Background The impact of different types of extracranial bleeding events on health‐related quality of life and health‐state utility among patients with atrial fibrillation is not well understood. Methods and Results The ENGAGE AF ‐ TIMI 48 (Effective Anticoagulation With Factor Xa Next Generation in Atrial Fibrillation–Thrombolysis in Myocardial Infarction 48) Trial compared edoxaban with warfarin with respect to the prevention of stroke or systemic embolism in atrial fibrillation. Data from the EuroQol‐5D ( EQ ‐5D‐3L) questionnaire, prospectively collected at 3‐month intervals for up to 48 months, were used to estimate the impact of different categories of bleeding events on health‐state utility over 12 months following the event. Longitudinal mixed‐effect models revealed that major gastrointestinal bleeds and major nongastrointestinal bleeds were associated with significant immediate decreases in utility scores (−0.029 [−0.044 to −0.014; P P =0.001], respectively). These effects decreased in magnitude over time, and were no longer significant for major nongastrointestinal bleeds at 9 months, but remained borderline significant for major gastrointestinal bleeds at 12 months. Clinically relevant nonmajor and minor bleeds were associated with smaller but measurable immediate impacts on utility (−0.010 [−0.016 to −0.005] and −0.016 [−0.024 to −0.008]; P Conclusions All categories of bleeding events were associated with negative impacts on health‐state utility in patients with atrial fibrillation. Major bleeds were associated with relatively large immediate decreases in utility scores that gradually diminished over 12 months; clinically relevant nonmajor and minor bleeds were associated with smaller immediate decreases in utility that persisted over 12 months. Clinical Trial Registration URL: https://www.clinicaltrials.gov/ . Unique identifier: NCT00781391.
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- 2017
41. PSEUDOMONAS SERINE-CARBOXYL PROTEINASE (SEDOLISIN) COMPLEXED WITH THE INHIBITOR AIAF
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Wlodawer, A., primary, Li, M., additional, Gustchina, A., additional, Dauter, Z., additional, Uchida, K., additional, Oyama, H., additional, Goldfarb, N.E., additional, Dunn, B.M., additional, and Oda, K., additional
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- 2018
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42. PSEUDOMONAS SERINE-CARBOXYL PROTEINASE (SEDOLISIN) COMPLEXED WITH THE INHIBITOR Chymostatin
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Wlodawer, A., primary, Li, M., additional, Gustchina, A., additional, Dauter, Z., additional, Uchida, K., additional, Oyama, H., additional, Goldfarb, N.E., additional, Dunn, B.M., additional, and Oda, K., additional
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- 2018
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43. PSEUDOMONAS SERINE-CARBOXYL PROTEINASE (SEDOLISIN) COMPLEXED WITH THE INHIBITOR Tyrostatin
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Wlodawer, A., primary, Li, M., additional, Gustchina, A., additional, Dauter, Z., additional, Uchida, K., additional, Oyama, H., additional, Goldfarb, N.E., additional, Dunn, B.M., additional, and Oda, K., additional
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- 2018
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44. PSEUDOMONAS SERINE-CARBOXYL PROTEINASE (SEDOLISIN) COMPLEXED WITH THE INHIBITOR Pseudotyrostatin
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Wlodawer, A., primary, Li, M., additional, Gustchina, A., additional, Dauter, Z., additional, Uchida, K., additional, Oyama, H., additional, Goldfarb, N.E., additional, Dunn, B.M., additional, and Oda, K., additional
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- 2018
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45. Serum KL-6: a useful marker for early detection of methotrexate-induced interstitial pneumonia
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Oyama, T., Kohno, N., Oyama, H., Okuda, Y., Namba, S., and Takasugi, K.
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- 2002
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46. Towards Automatic Error Type Classification of Japanese Language Learners' Writing
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Oyama, H., Mamoru Komachi, and Matsumoto, Y.
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- 2013
47. Outcomes With Edoxaban Versus Warfarin in Patients With Previous Cerebrovascular Events Findings From ENGAGE AF-TIMI 48 (Effective Anticoagulation With Factor Xa Next Generation in Atrial Fibrillation-Thrombolysis in Myocardial Infarction 48)
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Burger, Kunkelova, V., Berka, L., Brodova, P., Bar, M., Bergovec, M., Vrazic, H., Matsushita, C., Premchand, R., Boyer, M., Bakliza, Z., Sutalo, K., Kirner, D., Steiner, R., Cvitkusic Lukenda, K., Samardzic, P., Buksa, B., Kartsagkoulis, E., Kaplan, P., Sopher, M., Young, G., Senior, R., Roberts, J., Mackin, A., Moriarty, A., Olympios, C., Green, M., Shandra, T., Zhurba, S., Logvinov, Y., Zharinov, O., Mudruk, I., Yena, L., Nahrebetskyy, V., Kraiz, I., Chompalova, B., Parishev, G., Kharalkar, H., Knezevic, A., Denchev, S., Usan, N., Kraydashenko, O., Milcheva, N., Stets, R., Donova, T., Gergova, V., Georgiev, B., Kostova, E., Goudev, A., Jaksic Jurinjak, S., Kinova, E., Hergeldjieva, V., Yagensky, A., Kamenova, P., Manolova, A., Vasilev, I., Mihov, A., Miteva, B., Kupnovytska, I., Mincheva, V., Jelic, V., Stoyanovski, V., Makar Ausperger, K., Nikolov, F., Vasilev, D., Pencheva, G., Kostov, K., Petranov, S., Boriani, G., Milusheva, T., Popov, A., Staneva, A., Momchilova-Lozeva, D., Francetic, I., Todorov, G., Nyagina, M., Tumbev, H., Tumbeva, D., Tzekova, M., Kitova, M., Manoylov, E., Dicker, D., Giovannelli, F., Archibald, J., Antle, S., Bhargava, R., Stafford, C., Bose, S., Hundseth, M., Cha, J., Otis, J., Romic, I., Ferri Certic, J., Chehayeb, R., Lepage, C., Tusek, S., Ciglenecki, N., Jeric, M., Chilvers, M., Car, S., Carevic, V., Vansickle, L., Kyyak, Y., Serik, S., Cleveland, D., Valley, S., Constance, C., Gauthier, M., Lasri, E., Costi, P., Masson, C., Coutu, B., Denis, I., du Preez, M., Kubanska, A., Dufresne, M., Krider, J., Eikelboom, J., Zondag, M., Fortin, C., Viau, C., Houbraken, D., Hatheway, R., Mabee, J., Bagatin, J., Lizogub, V., Atar, S., Heath, J., Scott, L., Ho, K., Perdomo Mejia, I., Ho, V., Hoag, G., Standring, R., Huynh, T., Perkins, L., Kouz, S., Roy, M., Labonte, R., Fuki, Y., Dewar, C., Lainesse, A., St-Germain, L., Lam, S., Lam, H., Lichtenstein, T., Roberts, P., Luton, R., Douglas, S., Sanchez Vallejo, G., Ma, P., Seib, M., MacCallum, C., Matthews, J., Malette, P., Vaillancourt, T., Maranda, C., Studenikow, E., Mawji, A., Morely, A., Morrison, D., Roth, M., Mucha, M., Volkov, V., Goncharov, O., Vizir, V., Sklyanna, O., Vatutin, M., Drapchak, I., Vakaliuk, I., Dharmarao, A., Zanwar, I., Thakur, B., Vinod, M. 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Rostasne, Palinkas, A., Berk, M., Nagy, A., Garman, V., Bensimhon, D., Swaim, D., Beinart, S., Craig, M., Bedwell, N., Luis-Valdes, M., Bedoya, R., Hoffman, T., Beasley, R., Kolumban, E., Merkely, B., Kiss, K., Wulf, M., Takeda, M., Benton, J., Bartkowiak, A., Gordon, L., Erdogan, D., Barrington, P., Faircloth, C., Barker, T., Altonen, D., Barber, M., Campbell, G., Baman, R., Batista, M., Baine, S., Thompson, B., Ayesu, K., Ermis, C., Alvarez, M., Sanchez, A., Bowen, L., Sanjurjo, M., Codutti, O., Saravia Toledo, S., Formoso, I., Schmidberg, J., Baldwin, E., Awasty, V., Cobos, D., Aude, Y., Strickland, S., Medvegy, M., Kiss, T., Attanti, S., Matoltsy, A., Rasmussen, L., Arouni, A., Shoaf, R., Arnold, T., York, T., Kabul, K., Kanadasi, M., Goloboulicz, A., Anderson, J., Schygiel, P., Buzzetti, C., Severino, P., Morara, P., Sosa Liprandi, M., Teves, M., Vico, M., Oto, A., Turgut, O., Persechino, F., Morell, Y., Amin, K., Lane, B., Alsheikh, T., MacDonald, H., Almquist, A., Anderson, C., Paraskevaidis, T., Kolk, R., Tandogan, I., Stern, A., Yigit, F., Yigit, Z., Arstall, M., Hoffmann, B., Colquhoun, D., Price-Smith, S., Crimmins, D., Slattery, A., Karakai, H. Horvathne, Lupkovics, G., Di Lenarda, A., Kovacs, Z., Gadepalli, R., Mariani, M., Kumagai, S., Luttermann, M., Krishnan, H., Dart, A., Venneklaas, U., Kay, S., Lueders, S., De Servi, S., Grosse, B., Davis, S., Baranyai, M., Silver, G., Flecknoe-Brown, S., Gates, P., Kovacs, I., Salminen, O., Koczka, M., Jakal, A., Jones, S., Pirelli, S., Lohrbaecher-Kozak, I., Bauch, F., Koenig, H., Lehman, R., Kiss, R., Saha, D., Barai, A., Roy, D., Bekal, S., Feil, J. Felfoldine, Meusel, P., Morrison, H., Biscardi, R., Kis, E., Hirayama, A., Allison, J., Godsey, W., Aliyar, P., Genova-Peeva, E., Kosztyu, M., Kleinecke-Pohl, U., Alexander, J., Brubaker, S., Akhter, F., Schoen, B., Reddy, R., Shankar, A. Ravi, Jungmair, W., Schmid, S., Junggeburth, J., De Pace, D., Ahmadpour, H., De Caterina, R., Hussain, A., Kaik, J., Ahmad, A., Beck, P., Zoghi, M., Batushkin, V., Fink, P., Reiling, S., Miyamoto, N., Adler, P., McKeirnan, M., Li, J., Paul, V., Batta, C., Serup-Hansen, K., Vuriya, A., Horacek, T., Schuppe, M., Kanakaridisz, N., Varga, A., Kimizu, T., Purnell, P., Perrett, L., Kishore, R., Szto, G., O'Shea, V., Capiau, L., Banaeian, F., De Bleecker, J., de Koning, K., De Tollenaere, M., Kara, M., Fiok, J., Szatmari, J., De Bruyne, L., Edes, I., Tsukimine, A., Muskoczki, E., Wiggers, H., Jakobsen, U., Torp-Pedersen, C., Forgione, C., Harada, K., Dioszeghy, P., Almaraz, S. Padilla, Desfontaines, P., Tincani, G., Heidbuchel, H., Camas, L. Velasquez, Cuccia, C., Meeusen, K., Herzet, J., Malmendier, D., Guerra, L., Mairesse, G., Raepers, M., Parque, J., Clinckemaille, N., Scavee, C., Samayoa, C. Sanchez, Pozuelos, J. Mayen, Arakawa, S., Huyberechts, D., Stockman, D., Jacobs, C., Vandekerckhove, Y., Svenningsen, A., Sand, N., Azhdari, M., Derycker, K., Peruzzotti, L., Comi, G., Vanwelden, J., Mino, K., Cervi, E., Sanchez, M., Gilat, T., van Welden, J., Vervoort, G., Mestdagh, I., Vrolix, M., Bazylevych, A., Vlasyuk, Z., Raae, D., Raymond, I., Beerts, C., Wollaert, B., Denie, D., Vincenzo de Paola, A. Amato, Coutinho, E., Lotufo, P. Andrade, de Melo, R. Ferreira, Atie, J., Motta, C., Alves da Costa, F. Augusto, Lahav, M., Estrada, M. Rodas, Ferraz, R. Franchin, Precoma, D. Bertolim, Guevara, S., Contzen, C., Weihrauch, D., Sehnem, E., Botelho, R., Cunha, S., Brondani, R., Fleck, N., Buhr, M., Kandekar, S., Ladenburger, K., Lavagnino, A. Ovando, Braun, R., Ishimaru, S., Chaves Junior, H., Silva, J., Costantini, C., Barroso, D., Jimenez, T., De Patta, M., Pereira, V., Duda, N., Bereznyakov, I., Laimer, R., Tomita, H., Ishii, Y., Dutra, O., Morgado, S., Saporito, W. Faustino, Seroqui, M., Ferreira, L., Araujo, E., Finimundi, H., Daitz, C., Gagliardi, R., Pereira, G., Gomes, M., Gomes, A., Guimaraes, A., Lebedynskaya, M., Petrovic, V., Overgaard, K., Ninho, L., Olsen, R., Nielsen, H., Jaeger, C., Barash, B., Veng-Olsen, T., Dotsenko, S., Pereira, L., Iversen, H., Madsen, H., Kulynych, R., Dzyak, G., Vasilyeva, L., Faynyk, A., Sorokivskyy, M., Gavrysyuk, V., Schnelzer, P., Ibsen, H., Adler, J., Dzublik, Y., Horbach, L., Husyev, V., Bouzo, M., Babbar, A., Loof, A., Blanc, J., Godlevska, O., Melgar, I. Guzman, Marcoviciu, D., Ramirez, V. de Leon, Sehr, B., Beyer-Westendorf, J., Vierbeck, S., Decoulx, E., Samburg, Y., Jorge, J., Cury, C., Karpenko, O., Hassager, C., Milla, O. Ayau, Kaiser, S., Christensen, L., Christensen, H., Dodt, K., Zidkova, E., Samkova, D., Vodnansky, P., Almeida, A., Kalil, C., Radaelli, G., Sebba Barroso de Souza, W. Kunz, Morales, K., Labrova, R., Nevolina, I., Karpenko, Y., Leaes, P., Luiz, R. Osorio, Blihar, O., Kaydashev, I., Berbari, H., Spinar, J., Spacek, R., Almeida, J. Pimenta, Gozalo, A., Slaby, J., Reichert, P., Jirsova, E., Podrazil, P., Gerasimenko, N., Pisova, J., Exarchou, E., Havlova, I., Petrova, I., Kifnidis, K., Reis, G., Kolomyyits, S., Peterka, K., Olsr, J., Bansal, N., Nechanicky, R., Vasylets, V., Kopytsya, M., Melichar, M., Krocova, E., Machova, V., Ludka, O., Petyunina, O., Kotseruba, V., Berrouschot, J., Kvasnicka, J., Avellar, K., Kuchar, R., Kovar, P., Katz Weiand, L. Reis, Korantanis, K., Kosek, Z., Kostkova, G., Leipelt, J., Rocha, J., Ishibashi, Y., Lohman, J., Panella, M., Nozaki, T., Abi-Mansour, P., Dvoieglazova, M., Pyrgakis, V., Koval, V., Ohirko, O., Kochrt, M., Kobza, R., Koval', O., Jirmar, R., Sakamoto, S., Jerabek, O., Jelinek, Z., Jarkovsky, P., Jandik, J., Hubac, J., Honkova, M., Barros, R., Gregor, P., Rao, M., Jambula, H., Golan, L., Anzai, T., Rodrigues, L., Rocha, M. Rubia, Rodrigues, A., Rodrigues, D., dos Santos, F. Rossi, Pagnan, L. Goncalves, Sampaio, R., do Val, R., Saraiva, J., Francek, L., Florian, J., Ferkl, R., Elbl, L., Cermak, O., Burianova, H., Brtko, M., Pinto, B., and Yalcin, R.
- Subjects
Male ,medicine.medical_specialty ,Pyridines ,medicine.medical_treatment ,030204 cardiovascular system & hematology ,Brain Ischemia ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Double-Blind Method ,Recurrence ,Edoxaban ,Internal medicine ,Atrial Fibrillation ,parasitic diseases ,Secondary Prevention ,medicine ,Humans ,Myocardial infarction ,cardiovascular diseases ,Stroke ,Aged ,Advanced and Specialized Nursing ,business.industry ,Hazard ratio ,Warfarin ,Anticoagulants ,Atrial fibrillation ,Thrombolysis ,Middle Aged ,medicine.disease ,nervous system diseases ,Thiazoles ,Treatment Outcome ,chemistry ,Anesthesia ,Cardiology ,Female ,Neurology (clinical) ,Cardiology and Cardiovascular Medicine ,business ,030217 neurology & neurosurgery ,TIMI ,medicine.drug - Abstract
Background and Purpose— Patients with atrial fibrillation and previous ischemic stroke (IS)/transient ischemic attack (TIA) are at high risk of recurrent cerebrovascular events despite anticoagulation. In this prespecified subgroup analysis, we compared warfarin with edoxaban in patients with versus without previous IS/TIA. Methods— ENGAGE AF-TIMI 48 (Effective Anticoagulation With Factor Xa Next Generation in Atrial Fibrillation-Thrombolysis in Myocardial Infarction 48) was a double-blind trial of 21 105 patients with atrial fibrillation randomized to warfarin (international normalized ratio, 2.0–3.0; median time-in-therapeutic range, 68.4%) versus once-daily edoxaban (higher-dose edoxaban regimen [HDER], 60/30 mg; lower-dose edoxaban regimen, 30/15 mg) with 2.8-year median follow-up. Primary end points included all stroke/systemic embolic events (efficacy) and major bleeding (safety). Because only HDER is approved, we focused on the comparison of HDER versus warfarin. Results— Of 5973 (28.3%) patients with previous IS/TIA, 67% had CHADS 2 (congestive heart failure, hypertension, age, diabetes, prior stroke/transient ischemic attack) >3 and 36% were ≥75 years. Compared with 15 132 without previous IS/TIA, patients with previous IS/TIA were at higher risk of both thromboembolism and bleeding (stroke/systemic embolic events 2.83% versus 1.42% per year; P P P P =0.02). No treatment subgroup interactions were found for primary efficacy ( P =0.86) or for intracranial hemorrhage ( P =0.28). Conclusions— Patients with atrial fibrillation with previous IS/TIA are at high risk of recurrent thromboembolism and bleeding. HDER is at least as effective and is safer than warfarin, regardless of the presence or the absence of previous IS or TIA. Clinical Trial Registration— URL: http://www.clinicaltrials.gov . Unique identifier: NCT00781391.
- Published
- 2016
48. Cardioversion of Atrial Fibrillation in ENGAGE AF-TIMI 48
- Author
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Seibert, H., Bolton, R., Florian, J., Nyman, K., Viitaniemi, J., Maenpaa, A., Laheaar, M., Lucijanic, T., Lappalainen, T., Jakala, P., Valpas, S., Hussi, E., Kaarleenkaski, S., Huikuri, H., Ratnik, E., Vahula, V., Rosenthal, A., Voitk, J., Paumets, M., Rivis, L., Laane, E., David, D., Kolk, R., Stern, A., Kaik, J., Serup-Hansen, K., Wiggers, H., Jakobsen, U., Torp-Pedersen, C., Svenningsen, A., Sand, N., Raae, D., Raymond, I., Petrovic, V., Overgaard, K., Olsen, R., Nielsen, H., Veng-Olsen, T., Iversen, H., Madsen, H., Ibsen, H., Loof, A., Hassager, C., Christensen, L., Christensen, H., Dodt, K., Zidkova, E., Samkova, D., Vodnansky, P., Labrova, R., Spinar, J., Spacek, R., Slaby, J., Reichert, P., Jirsova, E., Podrazil, P., Pisova, J., Havlova, I., Petrova, I., Peterka, K., Olsr, J., Nechanicky, R., Melichar, M., Krocova, E., Machova, V., Ludka, O., Kvasnicka, J., Kuchar, R., Kovar, P., Kosek, Z., Kostkova, G., Kochrt, M., Kobza, R., Jirmar, R., Jerabek, O., Jelinek, Z., Jarkovsky, P., Jandik, J., Hubac, J., Honkova, M., Gregor, P., Eikelboom, J., Krider, J., Dufresne, M., Kubanska, A., du Preez, M., Talbot, P., Denis, I., Coutu, B., Masson, C., Costi, P., Gauthier, M., Constance, C., Valley, S., Cleveland, D., Vansickle, L., Chilvers, M., Lepage, C., Chehayeb, R., Otis, J., Cha, J., Hundseth, M., Bose, S., Stafford, C., Bhargava, R., Antle, S., Archibald, J., Manoylov, E., Kitova, M., Tzekova, M., Tumbeva, D., Tumbev, H., Nyagina, M., Todorov, G., Momchilova-Lozeva, D., Staneva, A., Vasilev, I., Popov, A., Milusheva, T., Petranov, S., Kostov, K., Pencheva, G., Vasilev, D., Nikolov, F., Stoyanovski, V., Mincheva, V., Miteva, B., Mihov, A., Manolova, A., Kamenova, P., Hergeldjieva, V., Kinova, E., Goudev, A., Kostova, E., Georgiev, B., Gergova, V., Donova, T., Milcheva, N., Denchev, S., Parishev, G., Chompalova, B., Zimmermann, E. Burger, Zimmermann, S., Almeida, M., Boas, F. Villas, Lustosa, E., Sobral Filho, D., Carraro, A., Simoes, M., Vicente, C., Saraiva, J., do Val, R., Sampaio, R., Pagnan, L. Goncalves, dos Santos, F. Rossi, Rodrigues, D., Rodrigues, A., Rocha, M. Rubia, Rodrigues, L., Barros, R., Rocha, J., Leipelt, J., Katz Weiand, L. Reis, Avellar, K., Reis, G., Gozalo, A., Almeida, J. Pimenta, Luiz, R. Osorio, Leaes, P., Morales, K., Sebba Barroso de Souza, W. Kunz, Radaelli, G., Kalil, C., Almeida, A., Kaiser, S., Cury, C., Jorge, J., Pereira, L., Jaeger, C., Ninho, L., Guimaraes, A., Gomes, A., Hong, K., Gomes, M., Pereira, G., Gagliardi, R., Daitz, C., Finimundi, H., Araujo, E., Ferreira, L., Seroqui, M., Saporito, W. Faustino, Morgado, S., Dutra, O., Laimer, R., Campisto, Y., Duda, N., Pereira, V., De Patta, M., Barroso, D., Costantini, C., Silva, J., Berka, L., Chaves Junior, H., Fleck, N., Brondani, R., Cunha, S., Botelho, R., Sehnem, E., Precoma, D. Bertolim, Ferraz, R. Franchin, Alves da Costa, F. Augusto, Motta, C., Atie, J., de Melo, R. Ferreira, Lotufo, P. Andrade, Coutinho, E., Vincenzo de Paola, A. 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Rostasne, Palinkas, A., Nagy, A., Kolumban, E., Merkely, B., Kiss, K., Medvegy, M., Kiss, T., Matoltsy, A., Karakai, H. Horvathne, Lupkovics, G., Kovacs, Z., Baranyai, M., Kovacs, I., Koczka, M., Jakal, A., Kiss, R., Feil, J. Felfoldine, Kis, E., Kosztyu, M., Kanakaridisz, N., Varga, A., Fiok, J., Szatmari, J., Edes, I., Muskoczki, E., Dioszeghy, P., Almaraz, S. Padilla, Camas, L. Velasquez, Guerra, L., Samayoa, C. Sanchez, Pozuelos, J. Mayen, Sanchez, M., Estrada, M. Rodas, Guevara, S., Lavagnino, A. Ovando, Jimenez, T., Melgar, I. Guzman, Ramirez, V. de Leon, Milla, O. Ayau, Korantanis, K., Pyrgakis, V., Kartsagkoulis, E., Olympios, C., Dimitra, K., Moschos, N., Daskalaki, A., Kifnidis, K., Exarchou, E., Karamitsos, C., Tziortziotis, A., Bourlios, P., Mavronasiou, E., Alexopoulos, D., Winter, K., Wolde, C., Buelow-Johansen, B., Winkelmann, B., Weyland, K., Buchholz, M., Voehringer, Voehringer, Ludwig, I., Veltkamp, R., Zarpentin, C., Taggeselle, J., Stoehring, R., Bonin, K., Spitzer, S., Baylacher, M., Sohn, H., Gold, G., Hellmers, J., Schreckenberg, A., Schmidt, M., Schmidt, A., Schiewe, C., Dreykluft, K., Finsterbusch, T., Schenkenberger, I., Frommhold, R., Schellong, S., Szymanowski, N., Schaefer, A., Kuehlenborg, A., Rinke, A., Pilipenko, H., Rack, K., Kuhlmann, M., Proskynitopoulos, N., Pohl, W., Lewinsky, D., Piechatzek, R., Raddatz, K., Mueller-Glamann, M., Barbera, S., Muegge, A., Vogt, S., Mitrovic, V., Frahm, E., Meyer-Pannwitt, U., Braemer, U., Meissner, G., Hoefer, K., Maus, O., Wulf, M., Luttermann, M., Venneklaas, U., Lueders, S., Grosse, B., Lohrbaecher-Kozak, I., Bauch, F., Koenig, H., Meusel, P., Kleinecke-Pohl, U., Schoen, B., Jungmair, W., Schmid, S., Junggeburth, J., Fink, P., Horacek, T., Schuppe, M., Hoffmann, S., Dorn, S., Hoffmann, U., Bobbie, C., Dieckheuer, U., Heuer, H., Peitz, M., Hartmann, A., Otto, A., Grigat, C., Manuela, W., Fuchs, R., Schneider, K., Forck-Boedeker, K., Faghih, M., Herfurth, B., Drescher, T., Kranz, P., Degtyareva, E., Ayasse, D., Daut, W., Kara, M., Contzen, C., Weihrauch, D., Buhr, M., Ladenburger, K., Braun, R., Schnelzer, P., You, Z. 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- Published
- 2016
49. Stroke and Mortality Risk in Patients With Various Patterns of Atrial Fibrillation: Results From the ENGAGE AF-TIMI 48 Trial (Effective Anticoagulation With Factor Xa Next Generation in Atrial Fibrillation-Thrombolysis in Myocardial Infarction 48)
- Author
-
Jones, D., Gu, X. J., Liu, L., Grammer, M., Waseem, M., Roper, E., Harden, M., Zellner, C., Mason, T., Zeig, S., Curtis, S., Zakhary, B., Yousuf, K., Wharton, S., VonGerichten, S., Willis, J., Dowling, C., Williams, R., Gibson, C., Williams, D., Truva, C., Westcott, J., St Laurent, B., Weiss, R., Sanchez, G., Waxman, F., Locklear, T., Ward, S., Renaud, K., Walsh, R., Kilcup, S., Vossler, M., Washam, M., Vijay, N., Warren, K., Vicari, R., Parsons, T., Verma, S., Cardoza, T., Vemireddy, D., Harrelson, K. 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- Subjects
Male ,medicine.medical_specialty ,medicine.drug_mechanism_of_action ,Pyridines ,medicine.medical_treatment ,Factor Xa Inhibitor ,Hemorrhage ,030204 cardiovascular system & hematology ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Edoxaban ,Risk Factors ,Physiology (medical) ,Internal medicine ,Thromboembolism ,Atrial Fibrillation ,Medicine ,Humans ,atrial fibrillation ,cardiovascular diseases ,030212 general & internal medicine ,Myocardial infarction ,Stroke ,Aged ,business.industry ,Warfarin ,Anticoagulants ,Atrial fibrillation ,Thrombolysis ,thromboembolism ,bleeding ,medicine.disease ,mortality ,stroke ,Thiazoles ,Treatment Outcome ,chemistry ,Anesthesia ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,business ,TIMI ,medicine.drug ,Factor Xa Inhibitors - Abstract
Background— Whether the pattern of atrial fibrillation (AF) modifies the risk/benefit of anticoagulation is controversial. In ENGAGE AF-TIMI 48 trial (Effective Anticoagulation with Factor Xa Next Generation in Atrial Fibrillation–Thrombolysis in Myocardial Infarction 48), the factor Xa inhibitor edoxaban was noninferior to warfarin in preventing stroke or systemic embolic events and significantly reduced bleeding and cardiovascular mortality. However, detailed analyses by AF pattern have not been reported. Methods and Results— The 21 105 patients were categorized as having paroxysmal (P -adj =0.015) and permanent AF (1.95%/year; P -adj =0.004). Overall, all-cause mortality also was lower with paroxysmal (3.0%/year) compared with persistent (4.4%/year; P -adj P -adj Conclusions— In ENGAGE AF-TIMI 48 trial, patients with paroxysmal AF suffered fewer thromboembolic events and deaths compared with those with persistent and permanent AF. The efficacy and safety profile of edoxaban as compared with warfarin was consistent across the 3 patterns of AF. Clinical Trial Registration— URL: http://www.clinicaltrials.gov . Unique identifier: NCT00781391.
- Published
- 2016
50. Effects of duloxetine on pain and walking distance in neuropathic pain models via modulation of the spinal monoamine system
- Author
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Minami, K., primary, Tamano, R., additional, Kasai, E., additional, Oyama, H., additional, Hasegawa, M., additional, Shinohara, S., additional, and Asaki, T., additional
- Published
- 2017
- Full Text
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