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4,863 results on '"Oteo A"'

1. Epidemiological and clinical characterization of community, healthcare-associated and nosocomial colonization and infection due to carbapenemase-producing Klebsiella pneumoniae and Escherichia coli in Spain

Author

Salamanca-Rivera, Elena, Palacios-Baena, Zaira R., Cañada, Javier E., Moure, Zaira, Pérez-Vázquez, María, Calvo-Montes, Jorge, Martínez-Martínez, Luis, Cantón, Rafael, Ruiz Carrascoso, Guillermo, Pitart, Cristina, Navarro, Ferran, Bou, Germán, Mulet, Xavier, González-López, Juan José, Sivianes, Fran, Delgado-Valverde, Mercedes, Pascual, Álvaro, Oteo-Iglesias, Jesús, and Rodríguez-Baño, Jesús

Published
2024
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6. Prediction of Klebsiella phage-host specificity at the strain level

Author

Dimitri Boeckaerts, Michiel Stock, Celia Ferriol-González, Jesús Oteo-Iglesias, Rafael Sanjuán, Pilar Domingo-Calap, Bernard De Baets, and Yves Briers

Subjects
Science
Abstract

Abstract Phages are increasingly considered promising alternatives to target drug-resistant bacterial pathogens. However, their often-narrow host range can make it challenging to find matching phages against bacteria of interest. Current computational tools do not accurately predict interactions at the strain level in a way that is relevant and properly evaluated for practical use. We present PhageHostLearn, a machine learning system that predicts strain-level interactions between receptor-binding proteins and bacterial receptors for Klebsiella phage-bacteria pairs. We evaluate this system both in silico and in the laboratory, in the clinically relevant setting of finding matching phages against bacterial strains. PhageHostLearn reaches a cross-validated ROC AUC of up to 81.8% in silico and maintains this performance in laboratory validation. Our approach provides a framework for developing and evaluating phage-host prediction methods that are useful in practice, which we believe to be a meaningful contribution to the machine-learning-guided development of phage therapeutics and diagnostics.

Published
2024
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8. Feasibility study of a SiPM-fiber detector for non-invasive measurement of arterial input function for preclinical and clinical positron emission tomography

Author

Sara de Scals, Luis Mario Fraile, José Manuel Udías, Laura Martínez Cortés, Marta Oteo, Miguel Ángel Morcillo, José Luis Carreras-Delgado, María Nieves Cabrera-Martín, and Samuel España

Subjects
Positron emission tomography, Pharmacokinetic studies, Arterial input function, Scintillation fibers, Medical physics. Medical radiology. Nuclear medicine, R895-920
Abstract

Abstract Pharmacokinetic positron emission tomography (PET) studies rely on the measurement of the arterial input function (AIF), which represents the time-activity curve of the radiotracer concentration in the blood plasma. Traditionally, obtaining the AIF requires invasive procedures, such as arterial catheterization, which can be challenging, time-consuming, and associated with potential risks. Therefore, the development of non-invasive techniques for AIF measurement is highly desirable. This study presents a detector for the non-invasive measurement of the AIF in PET studies. The detector is based on the combination of scintillation fibers and silicon photomultipliers (SiPMs) which leads to a very compact and rugged device. The feasibility of the detector was assessed through Monte Carlo simulations conducted on mouse tail and human wrist anatomies studying relevant parameters such as energy spectrum, detector efficiency and minimum detectable activity (MDA). The simulations involved the use of 18F and 68Ga isotopes, which exhibit significantly different positron ranges. In addition, several prototypes were built in order to study the different components of the detector including the scintillation fiber, the coating of the fiber, the SiPMs, and the operating configuration. Finally, the simulations were compared with experimental measurements conducted using a tube filled with both 18F and 68Ga to validate the obtained results. The MDA achieved for both anatomies (approximately 1000 kBq/mL for mice and 1 kBq/mL for humans) falls below the peak radiotracer concentrations typically found in PET studies, affirming the feasibility of conducting non-invasive AIF measurements with the fiber detector. The sensitivity for measurements with a tube filled with 18F (68Ga) was 1.2 (2.07) cps/(kBq/mL), while for simulations, it was 2.81 (6.23) cps/(kBq/mL). Further studies are needed to validate these results in pharmacokinetic PET studies.

Published
2024
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9. Modelling the spatial risk of malaria through probability distribution of Anopheles maculipennis s.l. and imported cases

Author

Shirin Taheri, Mikel Alexander González, María José Ruiz-López, Sergio Magallanes, Sarah Delacour-Estrella, Javier Lucientes, Rubén Bueno-Marí, Josué Martínez-de la Puente, Daniel Bravo-Barriga, Eva Frontera, Alejandro Polina, Yasmina Martinez-Barciela, José Manuel Pereira, Josefina Garrido, Carles Aranda, Alfonso Marzal, Ignacio Ruiz-Arrondo, José Antonio Oteo, Martina Ferraguti, Rafael Gutíerrez-López, Rosa Estrada, Miguel Ángel Miranda, Carlos Barceló, Rodrigo Morchón, Tomas Montalvo, Laura Gangoso, Fátima Goiri, Ana L. García-Pérez, Santiago Ruiz, Beatriz Fernandez-Martinez, Diana Gómez-Barroso, and Jordi Figuerola

Subjects
Paludism, pathogeography, spatial epidemiology, species distribution modelling, risk maps, vector-borne diseases, Infectious and parasitic diseases, RC109-216, Microbiology, QR1-502
Abstract

Malaria remains one of the most important infectious diseases globally due to its high incidence and mortality rates. The influx of infected cases from endemic to non-endemic malaria regions like Europe has resulted in a public health concern over sporadic local outbreaks. This is facilitated by the continued presence of competent Anopheles vectors in non-endemic countries.We modelled the potential distribution of the main malaria vector across Spain using the ensemble of eight modelling techniques based on environmental parameters and the Anopheles maculipennis s.l. presence/absence data collected from 2000 to 2020. We then combined this map with the number of imported malaria cases in each municipality to detect the geographic hot spots with a higher risk of local malaria transmission.The malaria vector occurred preferentially in irrigated lands characterized by warm climate conditions and moderate annual precipitation. Some areas surrounding irrigated lands in northern Spain (e.g. Zaragoza, Logroño), mainland areas (e.g. Madrid, Toledo) and in the South (e.g. Huelva), presented a significant likelihood of A. maculipennis s.l. occurrence, with a large overlap with the presence of imported cases of malaria.While the risk of malaria re-emergence in Spain is low, it is not evenly distributed throughout the country. The four recorded local cases of mosquito-borne transmission occurred in areas with a high overlap of imported cases and mosquito presence. Integrating mosquito distribution with human incidence cases provides an effective tool for the quantification of large-scale geographic variation in transmission risk and pinpointing priority areas for targeted surveillance and prevention.

Published
2024
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10. Regulation of anti-phage defense mechanisms by using cinnamaldehyde as a quorum sensing inhibitor

Author

Antonio Barrio-Pujante, Inés Bleriot, Lucía Blasco, Laura Fernández-Garcia, Olga Pacios, Concha Ortiz-Cartagena, Felipe Fernández Cuenca, Jesús Oteo-Iglesias, and María Tomás

Subjects
cinnamaldehyde, phage resistance, Klebsiella pneumoniae, proteome, quorum sensing, anti-phage defense mechanisms, Microbiology, QR1-502
Abstract

BackgroundMultidrug-resistant bacteria and the shortage of new antibiotics constitute a serious health problem. This problem has led to increased interest in the use of bacteriophages, which have great potential as antimicrobial agents but also carry the risk of inducing resistance. The objective of the present study was to minimize the development of phage resistance in Klebsiella pneumoniae strains by inhibiting quorum sensing (QS) and thus demonstrate the role of QS in regulating defense mechanisms.ResultsCinnamaldehyde (CAD) was added to K. pneumoniae cultures to inhibit QS and thus demonstrate the role of the signaling system in regulating the anti-phage defense mechanism. The QS inhibitory activity of CAD in K. pneumoniae was confirmed by a reduction in the quantitative expression of the lsrB gene (AI-2 pathway) and by proteomic analysis. The infection assays showed that the phage was able to infect a previously resistant K. pneumoniae strain in the cultures to which CAD was added. The results were confirmed using proteomic analysis. Thus, anti-phage defense-related proteins from different systems, such as cyclic oligonucleotide-based bacterial anti-phage signaling systems (CBASS), restriction–modification (R–M) systems, clustered regularly interspaced short palindromic repeat-Cas (CRISPR-Cas) system, and bacteriophage control infection (BCI), were present in the cultures with phage but not in the cultures with phage and CAD. When the QS and anti-phage defense systems were inhibited by the combined treatment, proteins related to phage infection and proliferation, such as the tail fiber protein, the cell division protein DamX, and the outer membrane channel protein TolC, were detected.ConclusionInhibition of QS reduces phage resistance in K. pneumoniae, resulting in the infection of a previously resistant strain by phage, with a significant increase in phage proliferation and a significant reduction in bacterial growth. QS inhibitors could be considered for therapeutic application by including them in phage cocktails or in phage-antibiotic combinations to enhance synergistic effects and reduce the emergence of antimicrobial resistance.

Published
2024
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11. Characterizing carbapenemase-producing Escherichia coli isolates from Spain: high genetic heterogeneity and wide geographical spread

Author

Elias Dahdouh, Laro Gómez-Marcos, Javier E. Cañada-García, Eva Ramírez de Arellano, Aida Sánchez-García, Isabel Sánchez-Romero, Luis López-Urrutia, Pedro de la Iglesia, Alejandro Gonzalez-Praetorius, Jared Sotelo, Daniel Valle-Millares, Isabela Alonso-González, Verónica Bautista, Noelia Lara, Silvia García-Cobos, Emilia Cercenado, Belén Aracil, Jesús Oteo-Iglesias, María Pérez-Vázquez, Spanish Eco-Carba Study Group, Verónica Casquero, Olga Valiente, Almudena Alhambra Mosquera, Alia Eworo Ndongo, Susana Hernando Real, Luis Moisés Ruiz-Velasco, José Leiva, Nieves Balado, Adriana Ortega, Mar Olga Pérez Moreno, Ana Bordes, Cristobal del Rosario Quintana, María Eugenia Portillo, Caridad Sainz de Baranda, Gloria Trujillo, Begoña Palop, Carmen Aldea-Mansilla, Juan Cuadros, Yolanda Gil, Soledad Illescas Fernández-Bermejo, Ana Ramos, Salvador Giner, Antonio Casabella Pernas, M. Pilar Ortega Lafont, María Huertas Vaquero, Isabel Antolín, Ma de los Ángeles Pallarés, Beatriz Iglesias, Frederic Gómez-Bertomeu, Ana Isabel López-Calleja, and Pilar Zamarrón

Subjects
carbapenemases, Escherichia coli, antibiotic resistance, virulence factor genes, whole-genome sequencing, sequence type, Microbiology, QR1-502
Abstract

IntroductionCarbapenemase-Producing Escherichia coli (CP-Eco) isolates, though less prevalent than other CP-Enterobacterales, have the capacity to rapidly disseminate antibiotic resistance genes (ARGs) and cause serious difficult-to-treat infections. The aim of this study is phenotypically and genotypically characterizing CP-Eco isolates collected from Spain to better understand their resistance mechanisms and population structure.MethodsNinety representative isolates received from 2015 to 2020 from 25 provinces and 59 hospitals Spanish hospitals were included. Antibiotic susceptibility was determined according to EUCAST guidelines and whole-genome sequencing was performed. Antibiotic resistance and virulence-associated genes, phylogeny and population structure, and carbapenemase genes-carrying plasmids were analyzed.Results and discussionThe 90 CP-Eco isolates were highly polyclonal, where the most prevalent was ST131, detected in 14 (15.6%) of the isolates. The carbapenemase genes detected were blaOXA-48 (45.6%), blaVIM-1 (23.3%), blaNDM-1 (7.8%), blaKPC-3 (6.7%), and blaNDM-5 (6.7%). Forty (44.4%) were resistant to 6 or more antibiotic groups and the most active antibiotics were colistin (98.9%), plazomicin (92.2%) and cefiderocol (92.2%). Four of the seven cefiderocol-resistant isolates belonged to ST167 and six harbored blaNDM. Five of the plazomicin-resistant isolates harbored rmt. IncL plasmids were the most frequent (45.7%) and eight of these harbored blaVIM-1. blaOXA-48 was found in IncF plasmids in eight isolates. Metallo-β-lactamases were more frequent in isolates with resistance to six or more antibiotic groups, with their genes often present on the same plasmid/integron. ST131 isolates were associated with sat and pap virulence genes. This study highlights the genetic versatility of CP-Eco and its potential to disseminate ARGs and cause community and nosocomial infections.

Published
2024
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13. Executive Summary of the Spanish Guidelines for the Diagnosis and Management of Imported Febrile Illnesses from the Spanish Society of Tropical Medicine and International Health (SEMTSI), the Imported Pathology Group of the Spanish Society of Infectious Diseases and Clinical Microbiology (GEPI-SEIMC), the Spanish Society of Family and Community Medicine (SEMFYC), the Spanish Society of Primary Care Physicians (SEMERGEN) and the Spanish Society of Emergency Medicine (SEMES)

Author

Camprubí-Ferrer, Daniel, Díaz Menendez, Marta, Crespillo-Andújar, Clara, Galparsoro, Harkaitz Azkune, Belhassen-Garcia, Moncef, Cuadros González, Juan, Rubio, Jose M., Llenas García, Jara, Oteo, Jose A., Gayoso Martín, Sara, Santos Larrégola, Laura, Salvador, Fernando, Rojo-Marcos, Gerardo, Balerdi-Sarasola, Leire, Kortajarena Urkola, Xabier, Soriano Pérez, Manuel Jesús, Onieva-García, María Ángeles, Alegría Coll, Iñaki, Arranz, Javier, and Membrillo de Novales, Javier

Published
2024
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14. Resumen ejecutivo de las Guías Española de Diagnóstico y Manejo de Enfermedades Febriles Importadas de la Sociedad Española de Medicina Tropical y Salud Internacional (SEMTSI), el Grupo de Patología Importada de la Sociedad Española de Enfermedades Infecciosas y microbiología clínica (GEPI-SEIMC), la Sociedad Española de Medicina de Familia y Comunitaria (SEMFYC), la Sociedad Española de Médicos de Atención Primaria (SEMERGEN) y la Sociedad Española de Medicina de Urgencias y Emergencias (SEMES)

Author

Camprubí-Ferrer, Daniel, Díaz Menendez, Marta, Crespillo-Andújar, Clara, Azkune Galparsoro, Harkaitz, Belhassen-Garcia, Moncef, Cuadros González, Juan, Rubio, Jose M., Llenas García, Jara, Oteo, Jose A., Gayoso Martín, Sara, Santos Larrégola, Laura, Salvador, Fernando, Rojo-Marcos, Gerardo, Balerdi-Sarasola, Leire, Kortajarena Urkola, Xabier, Soriano Pérez, Manuel Jesús, Onieva-García, María Ángeles, Alegría Coll, Iñaki, Arranz, Javier, and Membrillo de Novales, Javier

Published
2024
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15. The role of time perspective and acculturative stress on adaptive and maladaptive stress coping strategies of Puerto Ricans living in the island of Puerto Rico and the state of Connecticut in mainland United States

Author

Olivera-Figueroa, Lening A., Papastamatelou, Julie, Unger, Alexander, Jimenez-Torres, Gladys Janice, Cuebas López, Kyriah A., López-Córdova, Nanet M., and Barkil-Oteo, Andres

Subjects
Coping (Psychology) -- Methods, Puerto Ricans -- Psychological aspects -- Health aspects -- Social aspects, Time perception -- Health aspects, Stress management -- Methods, Psychology and mental health
Abstract

We assessed the role of Time Perspective (TP) and acculturative stress on adaptive and maladaptive coping strategies, across healthy and treatment-seeking Puerto Ricans living in the island of Puerto Rico (PR), as well as at the state of Connecticut in mainland United States (US). Participants were comprised of 197 adults from the island of PR, as well as 138 adults from Connecticut. TP was measured through five categories assessed by the Zimbardo TP Inventory (Past Positive, Past Negative, Present Fatalistic, Present Hedonistic, and Future), the Deviation from a Balanced Time Perspective-revisited (DBTPr) coefficient, and the Deviation from the Negative Time Perspective (DNTP) coefficient. Acculturative stress was measured with the Acculturative Distress Scale. Adaptive and maladaptive stress-coping were measured through the Brief COPE Inventory. DNTP predicted adaptive coping, whereas acculturative stress, Present Hedonistic, and DBTPr predicted maladaptive coping. Puerto Ricans living in Connecticut engaged more often in maladaptive coping than those in PR. Acculturative stress partially mediated the influence of DBTPr on maladaptive coping. DNTP mediated the influence of state on adaptive coping. DBTPr and acculturative stress totally mediated the influence of state on maladaptive coping. These findings suggest that assessing TP, levels of acculturative stress, and coping strategies could assist in tailoring evidence-based interventions to the specific needs of Puerto Rican populations. Doing so could be effective in promoting a Balanced Time Perspective, reducing acculturative stress, increasing adaptive coping, and improving mental as well as physical health, on Puerto Ricans living in PR or mainland US., Author(s): Lening A. Olivera-Figueroa [sup.1] [sup.2] , Julie Papastamatelou [sup.3] , Alexander Unger [sup.4] , Gladys Janice Jimenez-Torres [sup.5] , Kyriah A. Cuebas López [sup.6] , Nanet M. López-Córdova [sup.7] [...]

Published
2023
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16. Contemporary use of cefazolin for MSSA infective endocarditis: analysis of a national prospective cohort

Author

Laura Herrera-Hidalgo, Patricia Muñoz, Ana Álvarez-Uría, David Alonso-Menchén, Rafael Luque-Marquez, Encarnación Gutiérrez-Carretero, María Del Carmen Fariñas, Jose Maria Miró, Miguel Angel Goenaga, Luis Eduardo López-Cortés, Basilio Angulo-Lara, Lucia Boix-Palop, Arístides de Alarcón, Fernando Fernández Sánchez, José Mª García de Lomas, Gabriel Rosas, Javier de la Torre Lima, Elena Bereciartua, María José Blanco Vidal, Roberto Blanco, María Victoria Boado, Marta Campaña Lázaro, Alejandro Crespo, Laura Guio Carrión, Mikel Del Álamo Martínez de Lagos, Gorane Euba Ugarte, Ane Josune Goikoetxea, Marta Ibarrola Hierro, José Ramón Iruretagoyena, Josu Irurzun Zuazabal, Leire López-Soria, Miguel Montejo, Javier Nieto, David Rodrigo, Regino Rodríguez, Yolanda Vitoria, Roberto Voces, Mª Victoria García López, Radka Ivanova Georgieva, Guillermo Ojeda, Isabel Rodríguez Bailón, Josefa Ruiz Morales, Ignacio Álvarez Rodríguez, Harkaitz Azkune Galparsoro, Elisa Berritu Boronat, Mª Jesús Bustinduy Odriozola, Cristina del Bosque Martín, Tomás Echeverría, Alberto Eizaguirre Yarza, Ana Fuentes, Miguel Ángel Goenaga, Muskilda Goyeneche del Río, Ángela Granda Bauza, José Antonio Iribarren, Xabier Kortajarena Urkola, José Ignacio Pérez-Moreiras López, Ainhoa Rengel Jiménez, Karlos Reviejo, Alberto Sáez Berbejillo, Elou Sánchez Haza, Rosa Sebastián Alda, Itziar Solla Ruiz, Irati Unamuno Ugartemendia, Diego Vicente Anza, Iñaki Villanueva Benito, Mar Zabalo Arrieta, Rafael Carrasco, Vicente Climent, Patricio Llamas, Esperanza Merino, Joaquín Plazas, Sergio Reus, Alberto Bouzas, Brais Castelo, José Cuenca, Laura Gutiérrez, Lucía Ramos, María Rodríguez Mayo, Joaquín Manuel Serrano, Dolores Sousa Regueiro, Francisco Javier Martínez, Mª del Mar Alonso, Beatriz Castro, Teresa Delgado Melian, Javier Fernández Sarabia, Dácil García Rosado, Julia González González, Juan Lacalzada, Lissete Lorenzo de la Peña, Alina Pérez Ramírez, Pablo Prada Arrondo, Fermín Rodríguez Moreno, Antonio Plata Ciezar, José Mª Reguera Iglesias, Víctor Asensi Álvarez, Carlos Costas, Jesús de la Hera, Jonnathan Fernández Suárez, Lisardo Iglesias Fraile, Víctor León Arguero, José López Menéndez, Pilar Mencia Bajo, Carlos Morales, Alfonso Moreno Torrico, Carmen Palomo, Begoña Paya Martínez, Ángeles Rodríguez Esteban, Raquel Rodríguez García, Mauricio Telenti Asensio, Manuel Almela, Juan Ambrosioni, Manuel Azqueta, Mercè Brunet, Marta Bodro, Ramón Cartañá, Guillermo Cuervo, Carlos Falces, Mariana J Fernández-Pittol, Guillermina Fita, David Fuster, Cristina García de la Mària, Delia García-Pares, Marta Hernández-Meneses, Jaume Llopis Pérez, Francesc Marco, José M. Miró, Asunción Moreno, David Nicolás, Salvador Ninot, Eduardo Quintana, Carlos Paré, Daniel Pereda, Juan M. Pericás, José L. Pomar, José Ramírez, Mercè Roque, Irene Rovira, Elena Sandoval, Marta Sitges, Dolors Soy, Adrián Téllez, José M. Tolosana, Bárbara Vidal, Jordi Vila, Iván Adán, David Alonso, Juan Carlos Alonso, Javier Bermejo, Emilio Bouza, Gregorio Cuerpo Caballero, Antonia Delgado Montero, Agustín Estévez, Ramón Fortuny Ribas, Esther Gargallo, Mª Eugenia García Leoni, Ana González Mansilla, Francisco Javier González Moraga, Víctor González Ramallo, Martha Kestler Hernández, Amaia Mari Hualde, Marina Machado, Mercedes Marín, Manuel Martínez-Sellés, Rosa Melero, Diego Monzón, María Olmedo, Álvaro Pedraz, Blanca Pinilla, Ángel Pinto, Cristina Rincón, Hugo Rodríguez-Abella, Marta Rodríguez-Créixems, Eduardo Sánchez-Pérez, Antonio Segado, Neera Toledo, Maricela Valerio, Pilar Vázquez, Eduardo Verde Moreno, Sofía de la Villa, Isabel Antorrena, Belén Loeches, Mar Moreno, Ulises Ramírez, Verónica Rial Bastón, María Romero, Sandra Rosillo, Jesús Agüero Balbín, Cristina Amado Fernández, Carlos Armiñanzas Castillo, Francisco Arnaiz de las Revillas, Manuel Cobo Belaustegui, María Carmen Fariñas, Concepción Fariñas-Álvarez, Marta Fernández Sampedro, Iván García, Claudia González Rico, Laura Gutiérrez-Fernández, Manuel Gutiérrez-Cuadra, José Gutiérrez Díez, Marcos Pajarón, José Antonio Parra, Ramón Teira, Jesús Zarauza, Jorge Calderón Parra, Marta Cobo, Fernando Domínguez, Pablo García Pavía, Ana Fernández Cruz, Antonio Ramos-Martínez, Isabel Sánchez Romero, Tomasa Centella, José Manuel Hermida, José Luis Moya, Pilar Martín-Dávila, Enrique Navas, Enrique Oliva, Alejandro del Río, Jorge Rodríguez-Roda Stuart, Soledad Ruiz, Carmen Hidalgo Tenorio, Sergio Sequera, Manuel Almendro Delia, Omar Araji, José Miguel Barquero, Román Calvo Jambrina, Marina de Cueto, Juan Gálvez Acebal, Irene Méndez, Isabel Morales, José Antonio Lepe, José López-Haldón, Rafael Luque-Márquez, Guillermo Marín, Antonio Ortiz-Carrellán, Eladio Sánchez-Domínguez, Luis Javier Alonso, Pedro Azcárate, José Manuel Azcona Gutiérrez, José Ramón Blanco, Estíbaliz Corral Armas, Lara García-Álvarez, José Antonio Oteo, Antonio Barros Membrilla, Antonino Ginel Iglesias, Sara Grillo, Rubén Leta Petracca, Joaquín López-Contreras, María Alba Rivera Martínez, M. Álvarez, A.L. Fernández, Amparo Martínez, A. Prieto, Benito Regueiro, E. Tijeira, Marino Vega, Amaia Aguirre Quiñonero, Ángela Alonso Miñambres, Juan Carlos Gainzarain Arana, Sara González de Alaiza Ortega, Miguel Ángel Morán Rodríguez, Anai Moreno Rodríguez, Zuriñe Ortiz de Zárate, José Joaquín Portu Zapirain, Ester Sáez de Adana Arroniz, Daisy Carolina Sorto Sánchez, Sánchez-Porto Antonio, Úbeda Iglesias Alejandro, José Mª Arribas Leal, Elisa García Vázquez, Alicia Hernández Torres, Ana Blázquez, Gonzalo de la Morena Valenzuela, Ángel Alonso, Javier Aramburu, Felicitas Elena Calvo, Paola Tarabini-Castellani, Eva Heredero Gálvez, Carolina Maicas Bellido, José Largo Pau, Mª Antonia Sepúlveda, Pilar Toledano Sierra, Sadaf Zafar Iqbal-Mirza, Eva Cascales Alcolea, Ivan Keituqwa Yañez, Julián Navarro Martínez, Ana Peláez Ballesta, Eduardo Moreno Escobar, Alejandro Peña Monje, Valme Sánchez Cabrera, David Vinuesa García, María Arrizabalaga Asenjo, Carmen Cifuentes Luna, Juana Núñez Morcillo, Mª Cruz Pérez Seco, Aroa Villoslada Gelabert, Carmen Aured Guallar, Nuria Fernández Abad, Pilar García Mangas, Marta Matamala Adell, Mª Pilar Palacián Ruiz, Juan Carlos Porres, Begoña Alcaraz Vidal, María Jesús Del Amor Espín, Francisco Buendía, Roberto Jiménez Sánchez, Rosario Mármol, Francisco Martínez, Antonio Meseguer, Beatriz Pérez, Leticia Risco, Zoser Saura, Vanina Silva, Mª Belén Villmarín, Mª Ángels Ribas Blanco, Enrique Ruiz de Gopegui Bordes, Laura Vidal Bonet, Miquel Vives Borràs, Mª Carmen Bellón Munera, Elena Escribano Garaizabal, Antonia Tercero Martínez, Juan Carlos Segura Luque, Cristina Badía, Lucía Boix Palop, Mariona Xercavins, Sónia Ibars, Xerach Bosch, Eloy Gómez Nebreda, Ibalia Horcajada Herrera, Irene Menduiña Gallego, Imanol Pulido, Héctor Marrero Santiago, Isabel de Miguel Martínez, Elena Pisos Álamo, Daniel San Román Sánchez, Jorge Boan Pérez, Eva Mª Aguilar Blanco, Mercedes Catalán González, María Angélica Corres Peiretti, Andrea Eixerés Esteve, Laura Domínguez Pérez, Santiago de Cossío Tejido, Francisco Galván Román, José Antonio García Robles, Francisco López Medrano, Mª Jesús López Gude, Mª Ángeles Orellana Miguel, Patrick Pilkington, Yolanda Revilla Ostalaza, Juan Ruiz Morales, Sebastián Ruiz Solís, Ana Sabín Collado, Marcos Sánchez Fernández, Javier Solera Rallo, Jorge Solís Martín, Francesc Escrihuela-Vidal, Jordi Carratalà, Inmaculada Grau, Carmen Ardanuy, Dámaris Berbel, José Carlos Sánchez Salado, Oriol Alegre, Alejandro Ruiz Majoral, Fabrizio Sbraga, Arnau Blasco, Laura Gracia Sánchez, Iván Sánchez-Rodríguez, Gonzalo Aldamiz, Beatriz Álvarez, Marina Bernal Palacios, Alfonso Cabello Úbeda, Ricardo Fernández Roblas, Rafael Hernández, Victoria Andrea Hortigüela Martín, Andrea Kallmeyer, Cristina Landaeta Kancev, Marta Martín, Miguel Morante Ruiz, Miguel Ángel Navas Lobato, Ana María Pello, Laura Prieto, Marta Tomás Mallebrera, Laura Varela, Mireia de la Peña Triguero, Ruth Esther Figueroa Cerón, Lara Ruiz Gómez, Mireia Ble, Juan Pablo Horcajada Gallego, Antonio José Ginel, Inmaculada López, Alexandra Mas, Antoni Mestres, Lluís Molina, Ramón Serrat, Núria Ribas, Francisca Sánchez, Ana Silverio, Marina Suárez, Luisa Sorlí, Lluís Recasens, Manuel Taurón, María Fernández Regueras, María Ángeles Mantecón Vallejo, José Ángel Pérez Rivera, Nuria Sánchez Mata, Antonia Calvo Cano, Miguel Fajardo Olivares, María Victoria Millán Núñez, and Agustín Muñoz Sanz

Subjects
Infective endocarditis, Methicillin-susceptible Staphylococcus aureus, Cefazolin, Antistaphylococcal penicillin, Infectious and parasitic diseases, RC109-216
Abstract

Objectives: This study aimed to assess the real use of cefazolin for methicillin-susceptible Staphylococcus aureus (MSSA) infective endocarditis (IE) in the Spanish National Endocarditis Database (GAMES) and to compare it with antistaphylococcal penicillin (ASP). Methods: Prospective cohort study with retrospective analysis of a cohort of MSSA IE treated with cloxacillin and/or cefazolin. Outcomes assessed were relapse; intra-hospital, overall, and endocarditis-related mortality; and adverse events. Risk of renal toxicity with each treatment was evaluated separately. Results: We included 631 IE episodes caused by MSSA treated with cloxacillin and/or cefazolin. Antibiotic treatment was cloxacillin, cefazolin, or both in 537 (85%), 57 (9%), and 37 (6%) episodes, respectively. Patients treated with cefazolin had significantly higher rates of comorbidities (median Charlson Index 7, P

Published
2023
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18. Incidencia, predictores e impacto pronóstico de una clase funcional disminuida inmediatamente después de un implante percutáneo de válvula aórtica

Author

Nuche, Jorge, Ternacle, Julien, Avvedimento, Marisa, Cheema, Asim N., Veiga-Fernández, Gabriela, Muñoz-García, Antonio J., Vilalta, Victoria, Regueiro, Ander, Asmarats, Luis, del Trigo, María, Serra, Vicenç, Bonnet, Guillaume, Jonveaux, Melchior, Esposito, Giovanni, Rezaei, Effat, de la Torre-Hernández, José M., Fernández-Nofrerías, Eduard, Vidal, Pablo, Gutiérrez-Alonso, Lola, Oteo, Juan Francisco, Belahnech, Yassin, Mohammadi, Siamak, Philippon, François, Modine, Thomas, Mesnier, Jules, and Rodés-Cabau, Josep

Published
2024
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19. Incidence, predictors, and prognostic significance of impaired functional status early after transcatheter aortic valve replacement

Author

Nuche, Jorge, Ternacle, Julien, Avvedimento, Marisa, Cheema, Asim N., Veiga-Fernández, Gabriela, Muñoz-García, Antonio J., Vilalta, Victoria, Regueiro, Ander, Asmarats, Luis, del Trigo, María, Serra, Vicenç, Bonnet, Guillaume, Jonveaux, Melchior, Esposito, Giovanni, Rezaei, Effat, de la Torre-Hernández, José M., Fernández-Nofrerías, Eduard, Vidal, Pablo, Gutiérrez-Alonso, Lola, Oteo, Juan Francisco, Belahnech, Yassin, Mohammadi, Siamak, Philippon, François, Modine, Thomas, Mesnier, Jules, and Rodés-Cabau, Josep

Published
2024
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20. Pseudomonasaeruginosa antimicrobial susceptibility profiles, resistance mechanisms and international clonal lineages: update from ESGARS-ESCMID/ISARPAE Group

Author

Oliver, Antonio, Rojo-Molinero, Estrella, Arca-Suarez, Jorge, Beşli, Yeşim, Bogaerts, Pierre, Cantón, Rafael, Cimen, Cansu, Croughs, Peter D., Denis, Olivier, Giske, Christian G., Graells, Tíscar, Daniel Huang, Te-Din, Iorga, Bogdan I., Karatuna, Onur, Kocsis, Béla, Kronenberg, Andreas, López-Causapé, Carla, Malhotra-Kumar, Surbhi, Martínez, Luis Martínez, Mazzariol, Annarita, Meyer, Sylvain, Naas, Thierry, Notermans, Daan W., Oteo-Iglesias, Jesús, Pedersen, Torunn, Pirš, Mateja, Poeta, Patricia, Poirel, Laurent, Pournaras, Spyros, Sundsfjord, Arnfinn, Szabó, Dora, Tambić-Andrašević, Arjana, Vatcheva-Dobrevska, Rossitza, Vitkauskienė, Astra, and Jeannot, Katy

Published
2024
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23. Interaction between maternal immune activation and peripubertal stress in rats: impact on cocaine addiction-like behaviour, morphofunctional brain parameters and striatal transcriptome

Author

Capellán, Roberto, Orihuel, Javier, Marcos, Alberto, Ucha, Marcos, Moreno-Fernández, Mario, Casquero-Veiga, Marta, Soto-Montenegro, María Luisa, Desco, Manuel, Oteo-Vives, Marta, Ibáñez-Moragues, Marta, Magro-Calvo, Natalia, Morcillo, Miguel Ángel, Ambrosio, Emilio, and Higuera-Matas, Alejandro

Published
2023
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25. Clinical, microbiological, and molecular characterization of pediatric invasive infections by Streptococcus pyogenes in Spain in a context of global outbreak

Author

Eva Ramírez de Arellano, Jesús Saavedra-Lozano, Pilar Villalón, Ana Jové-Blanco, David Grandioso, Jared Sotelo, Anna Gamell, Juan José González-López, Eloísa Cervantes, María José Gónzalez, Victoria Rello-Saltor, Cristina Esteva, Francisco Sanz-Santaeufemia, Genoveva Yagüe, Ángela Manzanares, Patricia Brañas, Enrique Ruiz de Gopegui, Jaime Carrasco-Colom, Federico García, Emilia Cercenado, Isabel Mellado, Elena del Castillo, María Pérez-Vazquez, Jesús Oteo-Iglesias, and Cristina Calvo

Subjects
Streptococcus pyogenes, children, invasive disease, outbreak, GAS, M1UK, Microbiology, QR1-502
Abstract

ABSTRACTIn December 2022, an alert was published in the UK and other European countries reporting an unusual increase in the incidence of Streptococcus pyogenes infections. Our aim was to describe the clinical, microbiological, and molecular characteristics of group A Streptococcus invasive infections (iGAS) in children prospectively recruited in Spain (September 2022–March 2023), and compare invasive strains with strains causing mild infections. One hundred thirty isolates of S. pyogenes causing infection (102 iGAS and 28 mild infections) were included in the microbiological study: emm typing, antimicrobial susceptibility testing, and sequencing for core genome multilocus sequence typing (cgMLST), resistome, and virulome analysis. Clinical data were available from 93 cases and 21 controls. Pneumonia was the most frequent clinical syndrome (41/93; 44.1%), followed by deep tissue abscesses (23/93; 24.7%), and osteoarticular infections (11/93; 11.8%). Forty-six of 93 cases (49.5%) required admission to the pediatric intensive care unit. iGAS isolates mainly belonged to emm1 and emm12; emm12 predominated in 2022 but was surpassed by emm1 in 2023. Spread of M1UK sublineage (28/64 M1 isolates) was communicated for the first time in Spain, but it did not replace the still predominant sublineage M1global (36/64). Furthermore, a difference in emm types compared with the mild cases was observed with predominance of emm1, but also important representativeness of emm12 and emm89 isolates. Pneumonia, the most frequent and severe iGAS diagnosed, was associated with the speA gene, while the ssa superantigen was associated with milder cases. iGAS isolates were mainly susceptible to antimicrobials. cgMLST showed five major clusters: ST28-ST1357/emm1, ST36-ST425/emm12, ST242/emm12.37, ST39/emm4, and ST101-ST1295/emm89 isolates.IMPORTANCEGroup A Streptococcus (GAS) is a common bacterial pathogen in the pediatric population. In the last months of 2022, an unusual increase in GAS infections was detected in various countries. Certain strains were overrepresented, although the cause of this raise is not clear. In Spain, a significant increase in mild and severe cases was also observed; this study evaluates the clinical characteristics and the strains involved in both scenarios. Our study showed that the increase in incidence did not correlate with an increase in resistance or with an emm types shift. However, there seemed to be a rise in severity, partly related to a greater rate of pneumonia cases. These findings suggest a general increase in iGAS that highlights the need for surveillance. The introduction of whole genome sequencing in the diagnosis and surveillance of iGAS may improve the understanding of antibiotic resistance, virulence, and clones, facilitating its control and personalized treatment.

Published
2024
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26. Valve Hemodynamics by Valve Size and 1-Year Survival Following Implantation of the Portico Valve in the Multicenter CONFIDENCE Registry

Author

Helge Möllmann, MD, Axel Linke, MD, Luis Nombela-Franco, MD, Martin Sluka, MD, Juan Francisco Oteo Dominguez, MD, Matteo Montorfano, MD, Won-Keun Kim, MD, Martin Arnold, MD, Mariuca Vasa-Nicotera, MD, Stephan Fichtlscherer, MD, Lenard Conradi, MD, Anthony Camuglia, MD, Francesco Bedogni, MD, Keshav Kohli, PhD, and Ganesh Manoharan, MD

Subjects
Aortic stenosis, Self-expanding, TAVI, TAVR, Transcatheter aortic valve implantation, Transcatheter aortic valve replacement, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Background: The CONtrolled delivery For ImproveD outcomEs with cliNiCal Evidence registry was initiated to characterize the clinical safety and device performance from experienced transcatheter aortic valve implantation (TAVI) centers in Europe and Australia that use the Portico valve to treat patients with severe aortic stenosis. We herein report for the first time the valve performance at 30-day across all implanted valve sizes and the 1-year survival from this registry. Methods: This was a prospective, multicenter, single-arm observational clinical investigation of patients clinically indicated for implantation of a Portico valve in experienced TAVI centers. Patients were treated with a commercially available valve (size 23, 25, 27, or 29 mm) using either the first-generation delivery system (DS) (n = 501) or the second-generation (FlexNav) DS (n = 500). Adverse events were adjudicated by an independent clinical events committee according to Valve Academic Research Consortium-2 criteria. Echocardiographic outcomes were assessed at 30 days by an independent core laboratory, and a survival check was performed at 1 year. Results: We enrolled 1001 patients (82.0 years, 62.5% female, 63.7% New York Heart Association functional class III/IV at baseline) from 27 clinical sites in 8 countries across Europe and one site in Australia. Implantation of a single valve was successful in 97.5% of subjects. Valve hemodynamics at 30 days were substantially improved relative to baseline, with large aortic valve areas and low mean gradients across all implanted valve sizes (aortic valve areas were 1.7 ± 0.4, 1.7 ± 0.5, 1.8 ± 0.5, and 2.0 ± 0.5 cm2, and mean gradients were 7.0 ± 2.7, 7.5 ± 4.7, 7.3 ± 3.3, and 6.4 ± 3.3 mmHg for 23, 25, 27, and 29 mm valve sizes, respectively). Across all implanted valve sizes, most patients (77.1%) had no patient-prosthesis mismatch. Death from any cause within 1 year occurred in 13.7% of the patients in the first-generation DS group as compared with 11.0% in the second-generation DS group (p = 0.2). Conclusions: The Portico valve demonstrated excellent hemodynamic performance across all valve sizes in a large cohort of subjects implanted in experienced TAVI centers. One-year survival rates were favorable when using both the first-generation and second-generation (FlexNav) DSs in this high-risk cohort. ClinicalTrials.gov Identifier: NCT03752866.

Published
2024
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27. Predicting the next pandemic: VACCELERATE ranking of the World Health Organization's Blueprint for Action to Prevent Epidemics

Author

Jon Salmanton-García, Pauline Wipfler, Janina Leckler, Pontus Nauclér, Patrick W. Mallon, Patricia C.J.L. Bruijning-Verhagen, Heinz-Joseph Schmitt, Ullrich Bethe, Ole F. Olesen, Fiona A. Stewart, Kerstin Albus, Oliver A. Cornely, Martin Busch, Ulrike Seifert, Andreas Widmer, Miki Nagao, Jordi Rello, Tatina Todorova, Sabina Cviljević, Christopher H. Heath, Ligita Jančorienė, Thea Koelsen Fischer, Hans Martin Orth, Isik Somuncu Johansen, Mehmet Doymaz, Athanasios Tragiannidis, Thomas Löscher, Jin-Fu Xu, Petr Husa, José Antonio Oteo, Mohammad I. Issack, Markus Zeitlinger, Roger Le Grand, Przemysław Zdziarski, Fatih Demirkan, Paloma Merino Amador, Tomás García-Lozano, Qing Cao, Lourdes Vázquez, Juan Pablo Caeiro, Peter Hermans, Shahroch Nahrwar, Korkut Avsar, Deepak Kumar, Norma Fernández, Masoud Mardani, Esther Segal, Angelo Pan, Despoina Gkentzi, Georgia Gioula, Jorge Alberto Cortés, Joaquim Oliveira, Pierre van Damme, Mohd Zaki Bin Mohd Zaili, Spinello Antinori, Birutė Zablockienė, Georgios Papazisis, Chioma Inyang Aneke, Maricela Valerio, Samuel McConkey, Avinash Aujayeb, Anna Maria Azzini, Jelena Roganović, Kristin Greve-Isdahl Mohn, Peter Kremsner, Effrossyni Gkrania-Klotsas, Dora Corzo, Nina Khanna, Tomasz Smiatacz, Simone Scheithauer, Maria Merelli, Boris Klempa, Radovan Vrḫovac, Antonio Ruggiero, Pankaj Chaudhary, Julio Maquera-Afaray, Miquel Ekkelenkamp, Pavel Jindra, Nikola Pantić, Gemma Jiménez Guerra, Guenter Weiss, Behrad Roohi, Christos D. Argyropoulos, Sven Aprne Silfverdal, Jens van Praet, Zumrut Sahbudak Bal, Souha Kanj, Barnaby Young, Zoi Dorothea Pana, Emmanuel Roilides, Stephen C. Stearns, Joost Wauters, Jesús Rodríguez Baño, Mathias W. Pletz, Maja Travar, Steven Kühn, Fernando Riera, Daniel Cornely, Vlad Jeni Laura, Philipp Koehler, Brian Eley, Pravin K. Nair, Sandra Ciesek, Ioana Diana Olaru, Laura Marques, Emanuele Pontali, Alexandra Naunheim, Adrian Lieb, Markus Gerhard, Joveria Qais Farooqi, Lance Turtle, Gustavo Adolfo Méndez, Rebecca Jane Cox, Nigel Goodman, Billie Caceca, Javier Pemán, Halima Dawood, Helena Hervius Askling, Anders Fomsgaard, Alejandra Calderón Hernández, Cornelia Staehelin, Chia-Ying Liu, Giancarlo Icardi, Elio Castagnola, Helmut J.F. Salzer, Jens Lundgren, Samir Javadli, and Fabio Forghieri

Subjects
WHO R&D Blueprint for action to prevent epidemics, Pandemic, Influenza viruses, Disease X, SARS-CoV-2, SARS-CoV, Arctic medicine. Tropical medicine, RC955-962, Infectious and parasitic diseases, RC109-216
Abstract

Introduction: The World Health Organization (WHO)'s Research and Development (R&D) Blueprint for Action to Prevent Epidemics, a plan of action, highlighted several infectious diseases as crucial targets for prevention. These infections were selected based on a thorough assessment of factors such as transmissibility, infectivity, severity, and evolutionary potential. In line with this blueprint, the VACCELERATE Site Network approached infectious disease experts to rank the diseases listed in the WHO R&D Blueprint according to their perceived risk of triggering a pandemic. VACCELERATE is an EU-funded collaborative European network of clinical trial sites, established to respond to emerging pandemics and enhance vaccine development capabilities. Methods: Between February and June 2023, a survey was conducted using an online form to collect data from members of the VACCELERATE Site Network and infectious disease experts worldwide. Participants were asked to rank various pathogens based on their perceived risk of causing a pandemic, including those listed in the WHO R&D Blueprint and additional pathogens. Results: A total of 187 responses were obtained from infectious disease experts representing 57 countries, with Germany, Spain, and Italy providing the highest number of replies. Influenza viruses received the highest rankings among the pathogens, with 79 % of participants including them in their top rankings. Disease X, SARS-CoV-2, SARS-CoV, and Ebola virus were also ranked highly. Hantavirus, Lassa virus, Nipah virus, and henipavirus were among the bottom-ranked pathogens in terms of pandemic potential. Conclusion: Influenza, SARS-CoV, SARS-CoV-2, and Ebola virus were found to be the most concerning pathogens with pandemic potential, characterised by transmissibility through respiratory droplets and a reported history of epidemic or pandemic outbreaks.

Published
2024
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28. Beyond the effects of HIV infection and integrase inhibitors-based therapies on oral bacteriome

Author

Pablo Villoslada-Blanco, Patricia Pérez-Matute, Emma Recio-Fernández, María Íñiguez, Pilar Blanco-Navarrete, Luis Metola, Valvanera Ibarra, Jorge Alba, María de Toro, and José A. Oteo

Subjects
Medicine, Science
Abstract

Abstract Oral microbiome is the second largest microbial community in humans after gut. Human immunodeficiency virus (HIV) infection triggers an impairment of the immune system which could favour the growth and the colonization of pathogens in the oral cavity, and this dysbiosis has been associated with oral manifestations that worsen the quality of life of these patients. Antiretroviral therapy (ART) could also drive changes in specific oral bacterial taxa associated with such periodontal diseases. Integrase strand transfer inhibitors (INSTIs), therapy of choice in the treatment of naive HIV-patients, are able to reverse the impact of HIV infection on systemic inflammation, gut permeability, and gut bacterial diversity/richness. The objective of this study was to analyse the effects of HIV infection per se and INSTIs on salivary bacteriome composition, taking into consideration other factors such as smoking, that could also have a significant impact on oral microbiome. To accomplish this objective, 26 non-HIV-infected volunteers and 30 HIV-infected patients (15 naive and 15 under INSTIs-regimen) were recruited. Salivary samples were collected to measure lysozyme levels. Oral bacteriome composition was analysed using 16S rRNA gene sequencing. Naive HIV-infected patients showed statistically higher levels of lysozyme compared to controls (p

Published
2023
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29. Assessing the recovery of Y chromosome microsatellites with population genomic data using Papio and Theropithecus genomes

Author

Giacomo Mutti, Gonzalo Oteo-Garcia, Matteo Caldon, Maria Joana Ferreira da Silva, Tânia Minhós, Guy Cowlishaw, Dada Gottelli, Elise Huchard, Alecia Carter, Felipe I. Martinez, Alessandro Raveane, and Cristian Capelli

Subjects
Medicine, Science
Abstract

Abstract Y chromosome markers can shed light on male-specific population dynamics but for many species no such markers have been discovered and are available yet, despite the potential for recovering Y-linked loci from available genome sequences. Here, we investigated how effective available bioinformatic tools are in recovering informative Y chromosome microsatellites from whole genome sequence data. In order to do so, we initially explored a large dataset of whole genome sequences comprising individuals at various coverages belonging to different species of baboons (genus: Papio) using Y chromosome references belonging to the same genus and more distantly related species (Macaca mulatta). We then further tested this approach by recovering Y-STRs from available Theropithecus gelada genomes using Papio and Macaca Y chromosome as reference sequences. Identified loci were validated in silico by a) comparing within-species relationships of Y chromosome lineages and b) genotyping male individuals in available pedigrees. Each STR was selected not to extend in its variable region beyond 100 base pairs, so that loci can be developed for PCR-based genotyping of non-invasive DNA samples. In addition to assembling a first set of Papio and Theropithecus Y-specific microsatellite markers, we released TYpeSTeR, an easy-to-use script to identify and genotype Y chromosome STRs using population genomic data which can be modulated according to available male reference genomes and genomic data, making it widely applicable across taxa.

Published
2023
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30. Candidatus Neoehrlichia mikurensis Infection in Patient with Antecedent Hematologic Neoplasm, Spain

Author

Paola González-Carmona, Aránzazu Portillo, Cristina Cervera-Acedo, Daniel González-Fernández, and José A. Oteo

Subjects
neoehrlichiosis, Candidatus Neoehrlichia mikurensis, ticks, Ixodes ricinus, lymphoma, hematologic neoplasm, Medicine, Infectious and parasitic diseases, RC109-216
Abstract

We report a confirmed case of Candidatus Neoehrlichia mikurensis infection in a woman in Spain who had a previous hematologic malignancy. Candidatus N. mikurensis infections should be especially suspected in immunocompromised patients who exhibit persistent fever and venous thrombosis, particularly if they live in environments where ticks are prevalent.

Published
2023
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31. A Prospective, Multicenter, Real-World Registry of Coronary Lithotripsy in Calcified Coronary Arteries: The REPLICA-EPIC18 Study

Author

Benito, Tomas, Escaned, Javier, Sánchez, Javier Jimeno, Moreiras, Javier Martin, Rivero, Borja, Nofrerias, Eduard Fernandez, Lozano, Iñigo, Roldan, Juan, García-Touchard, Arturo, Serrano, Carlos Arellano, Rivero, Fernando, Avanzas, Pablo, Almendarez, Marcel, Santos, Ramon Calviño, Esteban, Pablo Piñon, Yuskova, Maria, Redondo, Alfredo, D’Ascoli, Giulio, Mas, Adria Tramullas, Portero-Portaz, Juan J., García-Camarero, Tamara, Mohandes, Mohsen, Rubio, Tomas Canton, Suarez, Alfonso, Bayón, Jeremías, Oliveira, Julio Peral, Salgado, Carlos Alonso, Gómez-Hospital, Joan Antoni, González, Reyes, López-Minguez, José Ramón, Palazuelos, Jorge, Sliwinski, Frank, Fernandez, Guillermo Bastos, De Miguel Castro, Antonio, Rodriguez-Leor, Oriol, Cid-Alvarez, Ana Belen, Lopez-Benito, Maria, Gonzalo, Nieves, Vilalta, Victoria, Diarte de Miguel, Jose Antonio, López, Leticia Fernandez, Jurado-Roman, Alfonso, Diego, Alejandro, Oteo, Juan Francisco, Cuellas, Carlos, Trillo, Ramiro, Travieso, Alejandro, Alfonso, Fernando, Carrillo, Xavier, Vegas-Valle, José Miguel, Cortes-Villar, Carlos, Pascual, Isaac, Muñoz Camacho, Juan Francisco, Flores, Xacobe, Vera-Vera, Silvio, Moreu, Jose, Barreira de Sousa, Gilles, Martí, David, Jimenez-Mazuecos, Jesus, Fuertes, Monica, Ocaranza, Raymundo, de la Torre Hernandez, Jose Maria, Lozano, Fernando, Solana Martinez, Santiago G., Gómez-Lara, Josep, and Perez de Prado, Armando

Published
2024
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32. Thrombocytopenia after transcatheter aortic valve implantation

Author

Tirado-Conte, Gabriela, Panagides, Vassili, Vergara-Uzcategui, Carlos E., Veiga Fernández, Gabriela, Vílchez, Jean Paul, Cepas-Guillén, Pedro, Oteo, Juan Francisco, Barrero, Alejandro, Marroquín, Luis, Farjat-Pasos, Julio I., Arslani, Ketina, Jiménez-Quevedo, Pilar, Núñez-Gil, Iván, Mejía-Rentería, Hernán, Torre Hernández, José M. de la, Díez Gil, José Luis, Regueiro, Ander, Amat-Santos, Ignacio, Fernández-Ortiz, Antonio, Eid-Lidt, Guering, Backer, Ole de, Rodés-Cabau, Josep, and Nombela-Franco, Luis

Published
2024
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33. Impact of gender on in-hospital and long-term outcomes after transcatheter aortic valve implantation: an analysis of the Spanish TAVI registry

Author

Gabani, Rami, Brugaletta, Salvatore, Bujak, Kamil, Pèrez-Vizcayno, María José, Jiménez-Quevedo, Pilar, Arévalos, Víctor, Muñoz-García, Erika, Trillo-Nouche, Ramiro, del Valle, Raquel, de la Torre Hernández, José M., Salido, Luisa, Gutiérrez, Enrique, Pan, Manuel, Sánchez-Gila, Joaquín, García del Blanco, Bruno, Moreno, Raúl, Blanco Mata, Roberto, Oteo, Juan Francisco, Amat-Santos, Ignacio, Regueiro, Ander, Ten, Francisco, Nogales, Juan Manuel, Fernández-Nofrerías, Eduard, Andraka, Leire, Ferrer, María Cruz, Pinar, Eduardo, Romaguera, Rafael, Cuellas Ramón, Carlos, Alfonso, Fernando, García-Blas, Sergio, Piñero, Antonio, Ignasi, Julia, Díaz Mèndez, Rocío, Bordes, Pascual, Meseguer, Juan, Nombela-Franco, Luis, and Sabaté, Manel

Published
2024
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34. Registro español de hemodinámica y cardiología intervencionista. XXXIII informe oficial de la Asociación de Cardiología Intervencionista de la Sociedad Española de Cardiología (1990–2023)

Author

Carballo Garrido, Julio, Andraka, Leire, Gómez Jaume, Alfredo, Merino Otermin, Álvaro, Artáiz Urdaci, Miguel, Ruiz Salmerón, Rafael, Pérez de Prado, Armando, Cruz González, Ignacio, Calviño Santos, Ramon, Bayón, Jeremías, Trillo, Ramiro, Antonio Baz, José, Berenguer, Alberto, Casanova Sandoval, Juan M., Álvarez Antón, Salvador, Sabaté, Manel, Ruiz Nodar, Juan Miguel, Valero Picher, Ernesto, Amat Santos, Ignacio J., Ruiz Arroyo, José Ramón, Pinar Bermúdez, Eduardo, Íñigo-García, Luis Antonio, Arzamendi, Dabit, Jerez Valero, Miguel, Cerrato García, Pablo, Bosch Peligero, Eduard, Vaquerizo Montilla, Beatriz, Subinas Elorriaga, Asier, Sánchez Pérez, Ignacio, Jiménez Mazuecos, Francisco Javier, Tejada Ponce, David, Santos Martínez, Sandra, Moreu, José, Elízaga, Jaime, Cascón Pérez, José Domingo, García, Eulogio, Mainar, Vicente, Ávila González, María del Mar, Vergara, Rubén, Macaya, Carlos, Rasines Rodríguez, Alejandro, Fernández-Ortiz, Antonio, Ojeda Pineda, Soledad, Bethencourt González, Armando, Palazuelos, Jorge, López Palop, Ramón, Alegría Barrero, Eduardo, Camacho Freire, Santiago Jesús, Portero Pérez, María Pilar, Peña Perez, Gonzalo, Vázquez Álvarez, María Eugenia, Roura, Gerard, Agudelo, Víctor, Freixa, Xavier, Carrillo, Xavier, Mohandes, Mohsen, Muñoz Camacho, Juan F., Millán, Raúl, García del Blanco, Bruno, Sarnago, Fernando, Torres Bosco, Alfonso, Sáez, Roberto, Avanzas, Pablo, Pérez Vizcayno, María José, Caballero Borrego, Juan, Blanco Mata, Roberto, Merchán Herrera, Antonio, Luengo Mondéjar, Pablo, Lozano, Íñigo, Portales Fernández, Javier, Bosa Ojeda, Francisco, Martín Lorenzo, Pedro, Novo García, Enrique, Fernández Guerrero, Juan Carlos, González Caballero, Eva, Rivero, Fernando, Pomar, Francisco, Ruiz Quevedo, Valeriano, Morales Ponce, Francisco José, Ruiz García, Juan, Romero Vazquiánez, Manuela, Tellería, Miren, Baello Monge, Pascual, Botas Rodríguez, Javier, Franco Peláez, Juan Antonio, Unzue, Leire, Gómez Menchero, Antonio Enrique, Sánchez Recalde, Ángel, Jurado Román, Alfonso, Sainz Laso, Fermín, Fuertes Ferre, Georgina, Pimienta González, Raquel, Oteo Domínguez, Juan Francisco, Gutiérrez, Alejandro, Bullones Ramírez, Juan Antonio, Sánchez-Aquino González, Rosa, Frutos Garcia, Araceli, Fajardo Molina, Ricardo, Núñez Pernas, Daniel, Alonso Briales, Juan Horacio, Sánchez Gila, Joaquín, Sánchez Burguillos, Francisco J., Guisado Rasco, Agustín, Vizcaino Arellano, Manuela, Díez Gil, José Luis, de la Borbolla Fernández, Rafael García, Ramírez, Antonio, Larman, Mariano, Bastante, Teresa, Martín-Moreiras, Javier, and Cid Álvarez, Ana Belén

Published
2024
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36. Predicting the next pandemic: VACCELERATE ranking of the WorldHealth Organization's Blueprint forAction toPreventEpidemics

Author

Busch, Martin, Seifert, Ulrike, Widmer, Andreas, Nagao, Miki, Rello, Jordi, Todorova, Tatina, Cviljević, Sabina, Heath, Christopher H., Jančorienė, Ligita, Fischer, Thea Koelsen, Orth, Hans Martin, Johansen, Isik Somuncu, Doymaz, Mehmet, Tragiannidis, Athanasios, Löscher, Thomas, Xu, Jin-Fu, Husa, Petr, Oteo, José Antonio, Issack, Mohammad I., Zeitlinger, Markus, Le Grand, Roger, Zdziarski, Przemysław, Demirkan, Fatih, Amador, Paloma Merino, García-Lozano, Tomás, Cao, Qing, Vázquez, Lourdes, Caeiro, Juan Pablo, Hermans, Peter, Nahrwar, Shahroch, Avsar, Korkut, Kumar, Deepak, Fernández, Norma, Mardani, Masoud, Segal, Esther, Pan, Angelo, Gkentzi, Despoina, Gioula, Georgia, Cortés, Jorge Alberto, Oliveira, Joaquim, van Damme, Pierre, Bin Mohd Zaili, Mohd Zaki, Antinori, Spinello, Zablockienė, Birutė, Papazisis, Georgios, Aneke, Chioma Inyang, Valerio, Maricela, McConkey, Samuel, Aujayeb, Avinash, Azzini, Anna Maria, Roganović, Jelena, Greve-Isdahl Mohn, Kristin, Kremsner, Peter, Gkrania-Klotsas, Effrossyni, Corzo, Dora, Khanna, Nina, Smiatacz, Tomasz, Scheithauer, Simone, Merelli, Maria, Klempa, Boris, Vrḫovac, Radovan, Ruggiero, Antonio, Chaudhary, Pankaj, Maquera-Afaray, Julio, Ekkelenkamp, Miquel, Jindra, Pavel, Pantić, Nikola, Guerra, Gemma Jiménez, Weiss, Guenter, Roohi, Behrad, Argyropoulos, Christos D., Silfverdal, Sven Aprne, van Praet, Jens, Bal, Zumrut Sahbudak, Kanj, Souha, Young, Barnaby, Pana, Zoi Dorothea, Roilides, Emmanuel, Stearns, Stephen C., Wauters, Joost, Baño, Jesús Rodríguez, Pletz, Mathias W., Travar, Maja, Kühn, Steven, Riera, Fernando, Cornely, Daniel, Laura, Vlad Jeni, Koehler, Philipp, Eley, Brian, Nair, Pravin K., Ciesek, Sandra, Olaru, Ioana Diana, Marques, Laura, Pontali, Emanuele, Naunheim, Alexandra, Lieb, Adrian, Gerhard, Markus, Farooqi, Joveria Qais, Turtle, Lance, Méndez, Gustavo Adolfo, Cox, Rebecca Jane, Goodman, Nigel, Caceca, Billie, Pemán, Javier, Dawood, Halima, Askling, Helena Hervius, Fomsgaard, Anders, Hernández, Alejandra Calderón, Staehelin, Cornelia, Liu, Chia-Ying, Icardi, Giancarlo, Castagnola, Elio, Salzer, Helmut J.F., Lundgren, Jens, Javadli, Samir, Forghieri, Fabio, Salmanton-García, Jon, Wipfler, Pauline, Leckler, Janina, Nauclér, Pontus, Mallon, Patrick W., Bruijning-Verhagen, Patricia C.J.L., Schmitt, Heinz-Joseph, Bethe, Ullrich, Olesen, Ole F., Stewart, Fiona A., Albus, Kerstin, and Cornely, Oliver A.

Published
2024
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37. Ventricular Fibrillation during Optical Coherence Tomography

Author

Paula Vela Martín, Carlos Arellano Serrano, Álvaro Lorente Ros, Juan Francisco Oteo, and Arturo Garcia-Touchard

Subjects
optical coherence tomography, intracoronary imaging, ventricular fibrillation, myocardial ischemia, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

Optical Coherence Tomography (OCT) imaging is a valuable tool for complex coronary interventions. While complications are rare, the occurrence of ventricular arrhythmias during its use is one of the most feared. Unfortunately, the mechanism by which these arrhythmias arise remains unclear. We describe the case of a patient under continuous electrocardiographic (ECG) monitoring who experienced ventricular fibrillation during an OCT procedure. A detailed analysis of the ECG event sequence was performed, from the administration of the contrast medium to the onset of ventricular fibrillation. Utilizing the collected data, we examined potential precipitating factors based on the observed alterations in the electrocardiogram. A comprehensive understanding of the mechanisms underlying these arrhythmias is crucial for the development of preventive measures that avoid such incidents in the future.

Published
2024
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38. Screening for SARS-CoV-2 and Other Coronaviruses in Urban Pigeons (Columbiformes) from the North of Spain under a ‘One Health’ Perspective

Author

Aránzazu Portillo, Cristina Cervera-Acedo, Ana M. Palomar, Ignacio Ruiz-Arrondo, Paula Santibáñez, Sonia Santibáñez, and José A. Oteo

Subjects
avian coronaviruses, COVID-19, ‘One Health’, pigeons, RNA-dependent RNA polymerase (RdRp), SARS-CoV-2, Biology (General), QH301-705.5
Abstract

Coronaviruses have a major impact on human and animal health. The SARS-CoV-2, a beta coronavirus responsible for the COVID-19 pandemic, is a clear example. It continues circulating and causes human deaths, and its high replication rate results in numerous variants. Coronaviruses adapt to birds and mammals and constitute a serious threat, and new viruses are likely to emerge. Urban pigeons (Columbiformes) are synanthropic birds of great interest from a ‘One Health’ perspective, due to their interaction with humans and other animals. Aware that they may act as viral reservoirs and contribute to their spread, we aimed to investigate the possible presence of SARS-CoV-2 and other coronaviruses in Columbiformes in the city of Logroño, Spain. Oropharyngeal and cloacal swabs were tested using real-time (N1 and E genes from SARS-CoV-2) and conventional PCR assays (RdRp gene from all coronaviruses). SARS-CoV-2 was not detected. A total of 13.3% of pigeons harbored coronaviruses closely related to Gamma coronavirus (Igacovirus) from Columbiformes in Finland, Poland and China. Monitoring the emergence of a new variant of SARS-CoV-2 capable of infecting Columbiformes should continue. SARS-CoV-2 is still circulating, the viral RNA of this virus has been detected in avian species (Phasianidae and Anatidae), and other coronaviruses are associated with animals that are in close contact with humans. The presence of Gamma coronavirus in urban pigeons must be considered for the risk of surveillance of human infections.

Published
2024
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40. The Lyman Alpha Reference Sample XI: Efficient Turbulence Driven Ly{\alpha} Escape and the Analysis of IR, CO and [C II]158 {\mu}m

Author

Puschnig, J., Hayes, M., Östlin, G., Cannon, J., Smirnova-Pinchukova, I., Husemann, B., Kunth, D., Bridge, J., Herenz, E. C., Messa, M., and Oteo, I.

Subjects
Astrophysics - Astrophysics of Galaxies
Abstract

We study the global dust and (molecular) gas content in the Lyman Alpha Reference Sample (LARS), i.e. 14 local star-forming galaxies. We characterize their interstellar medium and relate newly derived properties to quantities relevant for Ly$\alpha$ escape. We observed LARS galaxies with Herschel/PACS, SOFIA/FIFI-LS, the IRAM 30m telescope and APEX, targeting far-infrared (FIR) continuum and emission lines of [C II]158$\mu$m, [O I]63$\mu$m, [O III]88$\mu$m and low-J CO lines. Using Bayesian methods we derive dust model parameters and estimate total gas masses for all LARS galaxies, taking into account a metallicity-dependent gas-to-dust ratio. Star formation rates were estimated from FIR, [C II]158$\mu$m and [O I]63$\mu$m luminosities. LARS covers a wide dynamic range in the derived properties, with FIR-based star formation rates from $\sim$0.5-100 $M_{\odot}\ yr^{-1}$, gas fractions between $\sim$15-80% and gas depletion times ranging from a few hundred Myr up to more than 10 Gyr. The distribution of LARS galaxies in the $\Sigma_{gas}$ vs. $\Sigma_{SFR}$ (Kennicutt-Schmidt plane) is thus quite heterogeneous. However, we find that LARS galaxies with the longest gas depletion times, i.e. relatively high gas surface densities ($\Sigma_{gas}$) and low star formation rate densities ($\Sigma_{SFR}$), have by far the highest Ly$\alpha$ escape fraction. A strong $\sim$linear relation is found between Ly$\alpha$ escape fraction and the total gas (HI+H$_2$) depletion time. We argue that the Ly$\alpha$ escape in those galaxies is driven by turbulence in the star-forming gas that shifts the Ly$\alpha$ photons out of resonance close to the places where they originate. We further report on an extreme [C II]158$\mu$m excess in LARS 5, corresponding to $\sim$14$\pm$3% of the FIR luminosity, i.e. the most extreme [C II]-to-FIR ratio observed in a non-AGN galaxy to date.

Published
2020
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41. The OTELO survey. A case study of [O III]4959,5007 emitters at <z> = 0.83

Author

Bongiovanni, Ángel, Ramón-Pérez, Marina, García, Ana María Pérez, Cerviño, Miguel, Cepa, Jordi, Nadolny, Jakub, Martínez, Ricardo Pérez, Alfaro, Emilio J., Castañeda, Héctor, Cedrés, Bernabé, de Diego, José A., Ederoclite, Alessandro, Fernández-Lorenzo, Mirian, Gallego, Jesús, González, J. Jesús, González-Serrano, J. Ignacio, Lara-López, Maritza A., Gómez, Iván Oteo, Torres, Carmen P. Padilla, Pintos-Castro, Irene, Pović, Mirjana, Sánchez-Portal, Miguel, Jones, D. Heath, Bland-Hawthorn, Joss, and Cabrera-Lavers, Antonio

Subjects
Astrophysics - Astrophysics of Galaxies
Abstract

The OTELO survey is a very deep, blind exploration of a selected region of the Extended Groth Strip and is designed for finding emission-line sources (ELSs). The survey design, observations, data reduction, astrometry, and photometry, as well as the correlation with ancillary data used to obtain a final catalogue, including photo-z estimates and a preliminary selection of ELS, were described in a previous contribution. Here, we aim to determine the main properties and luminosity function (LF) of the [O III] ELS sample of OTELO as a scientific demonstration of its capabilities, advantages, and complementarity with respect to other surveys. The selection and analysis procedures of ELS candidates obtained using tunable filter (TF) pseudo-spectra are described. We performed simulations in the parameter space of the survey to obtain emission-line detection probabilities. Relevant characteristics of [O III] emitters and the LF([O III]), including the main selection biases and uncertainties, are presented. A total of 184 sources were confirmed as [O III] emitters at a mean redshift z=0.83. The minimum detectable line flux and equivalent width (EW) in this ELS sample are $\sim$5 $\times$ 10$^{-19}$ erg s$^{-1}$ cm$^{2}$ and $\sim$6 \AA, respectively. We are able to constrain the faint-end slope ($\alpha = -1.03\pm0.08$) of the observed LF([O III]) at z=0.83. This LF reaches values that are approximately ten times lower than those from other surveys. The vast majority (84\%) of the morphologically classified [O III] ELSs are disc-like sources, and 87\% of this sample is comprised of galaxies with stellar masses of M$_\star$ $<$ 10$^{10}$ M$_{\odot}$., Comment: v1: 16 pages, 6 figures. Accepted in Astronomy \& Astrophysics. v2: Author added in metadata

Published
2020
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42. The OTELO survey. III. Demography, morphology, IR luminosity and environment of AGN hosts

Author

Ramón-Pérez, Marina, Bongiovanni, Ángel, García, Ana Mará Pérez, Cepa, Jordi, Nadolny, Jakub, Pintos-Castro, Irene, Lara-López, Maritza A., Navarro, Emilio J. Alfaro, Castañeda, Héctor O., Cerviño, Miguel, de Diego, José Antonio, Fernández-Lorenzo, Mirian, Gallego, Jesús, González, J. Jesús, González-Serrano, J. Ignacio, Gómez, Iván Oteo, Martínez, Ricardo Pérez, Pović, Mirjana, and Sánchez-Portal, Miguel

Subjects
Astrophysics - Astrophysics of Galaxies
Abstract

We take advantage of the capabilities of the OTELO survey to select and study the AGN population in the field. We performed an analysis of the properties of these objects, including their demography, morphology, and IR luminosity. Focusing on the population of H$\alpha$ emitters at $z \sim 0.4$, we also aim to study the environments of AGN and non-AGN galaxies at that redshift. We make use of the multiwavelength catalog of objects in the field compiled by the OTELO survey, unique in terms of minimum line flux and equivalent width. The OTELO pseudo-spectra allow the identification of emission lines and the spectral classification of the sources. We obtained a sample of 72 AGNs in the field of OTELO, selected with four different methods in the optical, X-rays, and mid-infrared bands. We find that using X-rays is the most efficient way to select AGNs. An analysis was performed on the AGN population of OTELO in order to characterize its members. At $z \sim 0.4$, we find that up to 26\% of our H$\alpha$ emitters are AGNs. At that redshift, AGNs are found in identical environments to non-AGNs, although they represent the most clustered group when compared to passive and star-forming galaxies. The majority of our AGNs at any redshift were classified as late-type galaxies, including a 16\% proportion of irregulars. Another 16\% of AGNs show signs of interactions or mergers. Regarding the infrared luminosity, we are able to recover all the luminous infrared galaxies (LIRGs) in the field of OTELO up to $z\sim 1.6$. We find that the proportion of LIRGs and ultra-luminous infrared galaxies (ULIRGs) is higher among the AGN population, and that ULIRGs show a higher fraction of AGNs than LIRGs., Comment: 31 pages, 32 figures. Published in Astronomy \& Astrophysics

Published
2020
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43. The OTELO survey. II. The faint-end of the H$\alpha$ luminosity function at z $\sim$ 0.40

Author

Ramón-Pérez, Marina, Bongiovanni, Ángel, García, Ana María Pérez, Cepa, Jordi, Lara-López, Maritza A., de Diego, José Antonio, Navarro, Emilio J. Alfaro, Castañeda, Héctor O., Cerviño, Miguel, Fernández-Lorenzo, Mirian, Gallego, Jesús, González, J. Jesús, González-Serrano, J. Ignacio, Nadolny, Jakub, Gómez, Iván Oteo, Martínez, Ricardo Pérez, Pintos-Castro, I., Pović, Mirjana, and Sánchez-Portal, Miguel

Subjects
Astrophysics - Astrophysics of Galaxies
Abstract

We take advantage of the capability of the OTELO survey to obtain the H$\alpha$ luminosity function (LF) at ${\rm z}\sim0.40$. Because of the deepest coverage of OTELO, we are able to determine the faint end of the LF, and thus better constrain the star formation rate and the number of galaxies at low luminosities. The AGN contribution to this LF is estimated as well. We make use of the multi-wavelength catalogue of objects in the field compiled by the OTELO survey, which is unique in terms of minimum flux and equivalent width. We also take advantage of the pseudo-spectra built for each source, which allow the identification of emission lines and the discrimination of different types of objects. The H$\alpha$ luminosity function at $z\sim0.40$ is obtained, which extends the current faint end by almost 1 dex, reaching minimal luminosities of $\log_{10}L_{\rm lim}=38.5$ erg s$^{-1}$ (or $\sim0.002\, \text{M}_\odot\text{ yr}^{-1})$. The AGN contribution to the total H$\alpha$ luminosity is estimated. We find that no AGN should be expected below a luminosity of $\log_{10}L=38.6$ erg s$^{-1}$. From the sample of non-AGN (presumably, pure SFG) at $z\sim0.40$ we estimated a star formation rate density of $\rho_{\rm SFR}=0.012\pm0.005\ {\rm \text{M}_{\odot}\ yr^{-1}\ Mpc^{-3}}$., Comment: 8 pages, 5 figures. Published in Astronomy \& Astrophysics

Published
2020
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44. The OTELO survey. I. Description, data reduction, and multi-wavelength catalogue

Author

Bongiovanni, Ángel, Ramón-Pérez, Marina, García, Ana Mará Pérez, Cepa, Jordi, Cerviño, Miguel, Nadolny, Jakub, Martínez, Ricardo Pérez, Navarro, Emilio J. Alfaro, Castañeda, Héctor O., de Diego, José Antonio, Ederoclite, Alessandro, Fernández-Lorenzo, Mirian, Gallego, Jesús, González, J. Jesús, González-Serrano, J. Ignacio, Lara-López, Maritza A., Gómez, Iván Oteo, Torres, Carmen P. Padilla, Pintos-Castro, Irene, Pović, Mirjana, Sánchez-Portal, Miguel, Jones, D. Heath, Bland-Hawthorn, Joss, and Cabrera-Lavers, Antonio

Subjects
Astrophysics - Astrophysics of Galaxies
Abstract

The evolution of galaxies through cosmic time is studied observationally by means of extragalactic surveys. The OTELO survey aims to provide the deepest narrow-band survey to date in terms of minimum detectable flux and emission line equivalent width in order to detect the faintest extragalactic emission line systems. In this way, OTELO data will complements other broad-band, narrow-band, and spectroscopic surveys. The red tunable filter of the OSIRIS instrument on the 10.4 m Gran Telescopio Canarias (GTC) is used to scan a spectral window centred at $9175 \AA$, which is free from strong sky emission lines, with a sampling interval of $6 \AA$ and a bandwidth of $12 \AA$ in the most deeply explored Extended Groth Strip region. Careful data reduction using improved techniques for sky ring subtraction, accurate astrometry, photometric calibration, and source extraction enables us to compile the OTELO catalogue. This catalogue is complemented with ancillary data ranging from deep X-ray to far-infrared, including high resolution HST images, which allow us to segregate the different types of targets, derive precise photometric redshifts, and obtain the morphological classification of the extragalactic objects detected. The OTELO multi-wavelength catalogue contains 11237 entries and is 50\% complete at AB magnitude 26.38. Of these sources, 6600 have photometric redshifts with an uncertainty $z_{phot}$ better than $0.2 (1+z_{phot})$. A total of 4336 of these sources correspond to preliminary emission line candidates, which are complemented by 81 candidate stars and 483 sources that qualify as absorption line systems. The OTELO survey products were released to the public on 2019., Comment: v1: 29 pages, 29 figures. Published in Astronomy \& Astrophysics. v2: author's affiliation and final statement in Abstract updated

Published
2020
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45. Corrigendum: CARB-ES-19 multicenter study of carbapenemase-producing Klebsiella pneumoniae and Escherichia coli from all Spanish provinces reveals interregional spread of high-risk clones such as ST307/OXA-48 and ST512/KPC-3

Author

Javier E. Cañada-García, Zaira Moure, Pedro J. Sola-Campoy, Mercedes Delgado-Valverde, María E. Cano, Desirèe Gijón, Mónica González, Irene Gracia-Ahufinger, Nieves Larrosa, Xavier Mulet, Cristina Pitart, Alba Rivera, Germán Bou, Jorge Calvo, Rafael Cantón, Juan José González-López, Luis Martínez-Martínez, Ferran Navarro, Antonio Oliver, Zaira R. Palacios-Baena, Álvaro Pascual, Guillermo Ruiz-Carrascoso, Jordi Vila, Belén Aracil, María Pérez-Vázquez, Jesús Oteo-Iglesias, and The GEMARA/GEIRAS-SEIMC/REIPI CARB-ES-19 Study Group

Subjects
CARB-ES-19 study, carbapenemases, whole genome sequencing, Klebsiella pneumoniae, high-risk clones, Microbiology, QR1-502
Published
2023
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46. Corrigendum: Phenotypic and molecular characterization of IMP-producing Enterobacterales in Spain: predominance of IMP-8 in Klebsiella pneumoniae and IMP-22 in Enterobacter roggenkampii

Author

Javier E. Cañada-García, Natalin Grippo, Eva Ramírez de Arellano, Verónica Bautista, Noelia Lara, Ana María Navarro, Teresa Cabezas, Nora Mariela Martínez-Ramírez, Silvia García-Cobos, Jorge Calvo, Emilia Cercenado, Belén Aracil, María Pérez-Vázquez, Jesús Oteo-Iglesias, and The Spanish IMP Study Group

Subjects
antimicrobial resistant bacteria, carbapenem resistance, whole genome sequencing, surveillance, IMP carbapenemase, Enterobacterales, Microbiology, QR1-502
Published
2023
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47. Pseudomonas aeruginosa antibiotic susceptibility profiles, genomic epidemiology and resistance mechanisms: a nation-wide five-year time lapse analysisResearch in context

Author

Miquel Àngel Sastre-Femenia, Almudena Fernández-Muñoz, María Antonia Gomis-Font, Biel Taltavull, Carla López-Causapé, Jorge Arca-Suárez, Luis Martínez-Martínez, Rafael Cantón, Nieves Larrosa, Jesús Oteo-Iglesias, Laura Zamorano, Antonio Oliver, Fátima Galán-Sánchez, Irene Gracia-Ahufinger, Carmen Liébana-Martos, Carolina Roldán, Juan Manuel Sánchez-Calvo, Encarnación Clavijo, Laura Mora-Navas, Javier Aznar, José Antonio Lepe, Ángel Rodríguez-Villodres, Esther Recacha, Francisco Javier Casas-Círia, Carmen Martínez-Rubio, Marco Antonio Sempere-Alcocer, Lina Martín-Hita, Cristina Seral, Ana Isabel López-Calleja, Carmen Aspiroz, Marisa Monforte, Pedro de la Iglesia-Martínez, Gemma Jimenez-Guerra, Elena Riera-Pérez, Carmen Collado, Carmen Gallegos, Xavier Mulet, Miquel Àngel Sastre-Femenía, María Siller-Ruiz, Jorge Calvo, Dolores Quesada, Jun Hao Wang, Cristina Pitart, Francesc Marco, Nuria Prim, Juan Pablo Horcajada, Eduardo Padilla, Ester Del Barrio-Tofiño, Belen Viñado-Pérez, Fe Tubau, Silvia Capilla, Antonio Casabella, Mar Olga Pérez-Moreno, Emma Padilla, Mónica Ballestero, Alba Rivera, Ferrán Navarro, Fréderic Gómez-Bertomeu, Sergio Pardo-Granell, Ester Picó-Plana, Dolores Guerrero, Carolina Sarvisé-Buil, Alba Belles-Belles, Marta Fernández-Esgueva, María del Pilar Ortega-Lafont, Inmaculada García, Noelia Arenal-Andrés, Susana Hernando-Real, Rosario Ibáñez, Jesús Martínez, Federico Becerra, Carmen Aldea-Mansilla, Asmaa Alaoui-Sosse, José Carlos González, Julia Guzman-Puche, Miguel Ángel Blázquez-Andrada, Nora Mariela Martínez-Ramírez, Alicia Beteta, Bárbara Gomila-Sard, Salvador Giner Almaraz, Eugenio Garduño, Pedro Miguel Juiz-González, Javier Alba, Pilar Alonso, Ana Isabel Rodríguez, María Isabel Paz-Vidal, Marta García-Campello, Pablo Camacho, María de los Ángeles Pallarés, María Luisa Pérez del Molino, Amparo Coira, Gema Barbeito, Anniris Rincón, Francisco José Vasallo-Vidal, Laura Alonso-Acero, Laura Iglesias-Llorente, Ana Bordes-Benites, Laura Florén-Zabala, José Manuel Azcona, Carla Andrea Alonso, Yolanda Sáenz, Marta Lamata-Subero, David Molina, Ana González-Torralba, Jennifer Villa, Esther Viedma, Emilia Cercenado, Teresa Alarcón, Paula Vargas, María Díez, Patricia Ruiz, María Isabel Sánchez-Romero, Felipe Pérez-García, Genoveva Yagüe-Guirao, Amaia Concepción Oteiza, José Leiva, María Eugenia Portillo, Andrés Canut-Blasco, Matxalen Vidal, Iker Alonso, Maider Zuriarrain, and José Luis Barrios-Andrés

Subjects
Post-acute sequelae of SARS-CoV-2, PASC, COVID-19, SARS-CoV-2, Electronic health records, Public aspects of medicine, RA1-1270
Abstract

Summary: Background: Pseudomonas aeruginosa healthcare-associated infections are one of the top antimicrobial resistance threats world-wide. In order to analyze the current trends, we performed a Spanish nation-wide high-resolution analysis of the susceptibility profiles, the genomic epidemiology and the resistome of P. aeruginosa over a five-year time lapse. Methods: A total of 3.180 nonduplicated P. aeruginosa clinical isolates from two Spanish nation-wide surveys performed in October 2017 and 2022 were analyzed. MICs of 13 antipseudomonals were determined by ISO-EUCAST. Multidrug resistance (MDR)/extensively drug resistance (XDR)/difficult to treat resistance (DTR)/pandrug resistance (PDR) profiles were defined following established criteria. All XDR/DTR isolates were subjected to whole genome sequencing (WGS). Findings: A decrease in resistance to all tested antibiotics, including older and newer antimicrobials, was observed in 2022 vs 2017. Likewise, a major reduction of XDR (15.2% vs 5.9%) and DTR (4.2 vs 2.1%) profiles was evidenced, and even more patent among ICU isolates [XDR (26.0% vs 6.0%) and DTR (8.9% vs 2.6%)] (p

Published
2023
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48. Developing a Theoretically Informed Implementation Model for Telemedicine-Delivered Medication for Opioid Use Disorder: Qualitative Study With Key Informants

Author

Joseph Tay Wee Teck, Rosalind Gittins, Giedre Zlatkute, Alberto Oteo Pérez, Susanna Galea-Singer, and Alexander Baldacchino

Subjects
Psychology, BF1-990
Abstract

BackgroundTelemedicine-delivered medication for opioid use disorder (TMOUD) has become more prevalent during the COVID-19 pandemic, particularly in North America. This is considered a positive development as TMOUD has the potential to increase access to evidence-based treatment for a population heavily affected by the opioid crisis and consequent rising mortality and morbidity rates in relation to opioid use disorder. Despite the increase in the use of TMOUD, there are no established service- and process-focused models to guide the implementation of this intervention. ObjectiveThis study aims to develop a process- and service-focused implementation model in collaboration with key stakeholders and bring together peer-reviewed literature, practice-based knowledge, and expert opinions. MethodsThe simple rules for evidence translation in complex systems framework was applied to guide the development of a 6-step qualitative study. The steps were definition of the scope and objectives of the model, identification of evidence, stakeholder engagement, draft model development, key informant consultation, and final model specification. ResultsThe final specification for the TMOUD implementation model incorporated key strategic priorities, service delivery prerequisites, service design elements, stakeholder identification and engagement, key process domains, and iterative cycles of evaluation and improvement. ConclusionsThrough stakeholder engagement and key informant consultation, we produced a process- and service-focused TMOUD implementation model. The model is modifiable to different contexts and settings while also in keeping with the current evidence base and national and international standards of high-quality opioid use disorder care.

Published
2023
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49. Molecular studies of phages-Klebsiella pneumoniae in mucoid environment: innovative use of mucolytic agents prior to the administration of lytic phages

Author

Olga Pacios, Lucía Blasco, Concha Ortiz Cartagena, Inés Bleriot, Laura Fernández-García, María López, Antonio Barrio-Pujante, Felipe Fernández Cuenca, Belén Aracil, Jesús Oteo-Iglesias, and María Tomás

Subjects
Klebsiella pneumoniae, lytic bacteriophages, phage resistance, co-evolution, mucin, n-acetyl cysteine, Microbiology, QR1-502
Abstract

Mucins are important glycoproteins that form a protective layer throughout the gastrointestinal and respiratory tracts. There is scientific evidence of increase in phage-resistance in the presence of mucin for some bacterial pathogens. Manipulation in mucin composition may ultimately influence the effectiveness of phage therapy. In this work, two clinical strains of K. pneumoniae (K3574 and K3325), were exposed to the lytic bacteriophage vB_KpnS-VAC35 in the presence and absence of mucin on a long-term co-evolution assay, in an attempt to mimic in vitro the exposure to mucins that bacteria and their phages face in vivo. Enumerations of the bacterial and phage counts at regular time intervals were conducted, and extraction of the genomic DNA of co-evolved bacteria to the phage, the mucin and both was performed. We determined the frequency of phage-resistant mutants in the presence and absence of mucin and including a mucolytic agent (N-acetyl L-cysteine, NAC), and sequenced them using Nanopore. We phenotypically demonstrated that the presence of mucin induces the emergence of bacterial resistance against lytic phages, effectively decreased in the presence of NAC. In addition, the genomic analysis revealed some of the genes relevant to the development of phage resistance in long-term co-evolution, with a special focus on the mucoid environment. Genes involved in the metabolism of carbohydrates were mutated in the presence of mucin. In conclusion, the use of mucolytic agents prior to the administration of lytic phages could be an interesting therapeutic option when addressing K. pneumoniae infections in environments where mucin is overproduced.

Published
2023
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50. The East Asian Observatory SCUBA--2 survey of the COSMOS field: unveiling 1147 bright sub-millimeter sources across 2.6 square degrees

Author

Simpson, J. M., Smail, Ian, Swinbank, A. M., Chapman, S. C., Chen, Chian-Chou, Geach, J. E., Matsuda, Y., Wang, R., Wang, Wei-Hao, Yang, Y., Ao, Y., Asquith, R., Bourne, N., Coogan, R. T., Coppin, K., Gullberg, B., Hine, N. K., Ho, L. C., Hwang, H. S., Ivison, R. J., Kato, Y., Lacaille, K., Lewis, A. J. R., Liu, D., Michałowski, M. J., Oteo, I., Sawicki, M., Scholtz, J., Smith, D., Thomson, A. P., and Wardlow, J. L.

Subjects
Astrophysics - Astrophysics of Galaxies
Abstract

We present sensitive 850$\mu$m imaging of the COSMOS field using 640hr of new and archival observations taken with SCUBA-2 at the East Asian Observatory's James Clerk Maxwell Telescope. The SCUBA-2 COSMOS survey (S2COSMOS) achieves a median noise level of $\sigma_{850\mu{\mathrm{m}}}$=1.2mJy/beam over an area of 1.6 sq. degree (MAIN; HST/ACS footprint), and $\sigma_{850\mu{\mathrm{m}}}$=1.7mJy/beam over an additional 1 sq. degree of supplementary (SUPP) coverage. We present a catalogue of 1020 and 127 sources detected at a significance level of >4$\sigma$ and >4.3$\sigma$ in the MAIN and SUPP regions, respectively, corresponding to a uniform 2% false-detection rate. We construct the single-dish 850$\mu$m number counts at $S_{850}$>2mJy and show that these S2COSMOS counts are in agreement with previous single-dish surveys, demonstrating that degree-scale fields are sufficient to overcome the effects of cosmic variance in the $S_{850}$=2-10mJy population. To investigate the properties of the galaxies identified by S2COSMOS sources we measure the surface density of near-infrared-selected galaxies around their positions and identify an average excess of 2.0$\pm$0.2 galaxies within a 13$''$ radius (~100kpc at $z$~2). The bulk of these galaxies represent near-infrared-selected SMGs and/or spatially-correlated sources and lie at a median photometric redshift of $z$=2.0$\pm$0.1. Finally, we perform a stacking analysis at sub-millimeter and far-infrared wavelengths of stellar-mass-selected galaxies ($M_{\star}$=10$^{10}$-10$^{12}{\rm M_{\odot}}$) from $z$=0-4, obtaining high-significance detections at 850um in all subsets (SNR=4-30), and investigate the relation between far-infrared luminosity, stellar mass, and the peak wavelength of the dust SED. The publication of this survey adds a new deep, uniform sub-millimeter layer to the wavelength coverage of this well-studied COSMOS field., Comment: Published in ApJ July 2019

Published
2019
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