1. New flavonoids C-glycosides from Rhabdophyllum arnoldianum
- Author
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Marius Balemaken Missi, Cécile Enguehard-Gueiffier, Gaétan Bayiha Ba Njock, Dieudonné Emmanuel Pegnyemb, Joseph Thierry Ndongo, Alex de Théodore Atchadé, Joséphine Ngo Mbing, Alain Gueiffier, Université de Yaoundé I, Institut National de la Recherche Agronomique (INRA), Centre de Recherches en Plantes Médicinales et Médecine Traditionnelle, Institut de Recherches Médicales et d’Etudes des Plantes Médicinales (IMPM), Université de Genève (UNIGE), Infectiologie et Santé Publique (UMR ISP), Institut National de la Recherche Agronomique (INRA)-Université de Tours (UT), Agence Universitaire de la Francophonie (AUF), International Foundation for Science, Organisation for Prohibition of Chemical Weapons [N_F/3330-2], and Institut National de la Recherche Agronomique (INRA)-Université de Tours
- Subjects
C glycosides ,Staphylococcus aureus ,Rhabdophyllum arnoldianum ,[SDV]Life Sciences [q-bio] ,Ochnaceae ,Plant Science ,Microbial Sensitivity Tests ,Mass spectrometry ,Gram-Positive Bacteria ,01 natural sciences ,Biochemistry ,Analytical Chemistry ,Bacillus cereus ,Enterococcus faecalis ,Bioassay ,Cameroon ,Glycosides ,Nuclear Magnetic Resonance, Biomolecular ,Flavone glycosides ,Chromatography ,biology ,010405 organic chemistry ,Chemistry ,Organic Chemistry ,biology.organism_classification ,Antimicrobial ,BIFLAVONOIDS ,Flavones ,NMR ,0104 chemical sciences ,Anti-Bacterial Agents ,Plant Leaves ,010404 medicinal & biomolecular chemistry ,flavone glycosides ,Bacteria ,Bacillus subtilis - Abstract
International audience; Two new flavone glycosides, 3 ''-O-acetyl-7-O-methylvitexin (1) and 6 ''-alpha-rhamnopyranosyl-7-O-methylvitexin (2), along with nine known compounds (3-11) were isolated from the leaves of Rhabdophyllum arnoldianum (Ochnaceae). The structures of the new compounds were established by detailed spectroscopic studies and mass spectrometry, while known compounds were characterised by direct comparison of their reported NMR data with those found in the literature. All these compounds were the first reported from Rhabdophyllum genus. The biological assays on crude extracts and compounds of this plant demonstrated that the crude extracts possess significant antimicrobial activity against Gram-positive bacteria.
- Published
- 2014