1. Mechanisms underlying impaired spermatogenic function in orchitis induced by busulfan.
- Author
-
Zhao L, Zhao J, Dong Z, Xu S, and Wang D
- Subjects
- Male, Humans, Busulfan toxicity, Spermatogonia, Testis, Orchitis chemically induced, Orchitis metabolism, Infertility, Male metabolism
- Abstract
Busulfan is an alkylating agent commonly used in cancer chemotherapy. It is also an ideal agent for preparing transplant recipients of spermatogonial stem cells because of its high efficiency in destroying endogenous germ cells in the testis. However, its toxicity mechanism remains unclear, affecting its clinical use and applications. Based on reports of busulfan causing orchitis and a previous study by our team, this article summarizes the relationship between busulfan and orchitis, cytokines, the blood-testis barrier, and the cytoskeleton, unravels the regulatory pathways and mechanism behind busulfan-induced orchitis, and reveals the molecular mechanism underlying impaired spermatogenic function in orchitis, providing new ideas for the clinical application of busulfan while reducing its testicular toxicity., Competing Interests: Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Dong Wang reports financial support was provided by Jilin Agricultural University. Dong Wang reports financial support was provided by Foundation for Innovative Research Groups of the National Natural Science Foundation of China., (Copyright © 2022. Published by Elsevier Inc.)
- Published
- 2023
- Full Text
- View/download PDF