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Your search keyword '"Okumura, Tomoko"' showing total 155 results
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155 results on '"Okumura, Tomoko"'

2. Lysosomal degradation of PD-L1 is associated with immune-related adverse events during anti-PD-L1 immunotherapy in NSCLC patients

Author

Kashiwada, Takeru, primary, Takano, Ryotaro, additional, Ando, Fumihiko, additional, Kuroda, Shoko, additional, Miyabe, Yoshishige, additional, Owada, Ryuji, additional, Miyanaga, Akihiko, additional, Asatsuma-Okumura, Tomoko, additional, Hashiguchi, Masaaki, additional, Kanazawa, Yoshikazu, additional, Yoshida, Hiroshi, additional, Seike, Masahiro, additional, Gemma, Akihiko, additional, and Iwai, Yoshiko, additional

Published
2024
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3. Combination of plasma MMPs and PD-1-binding soluble PD-L1 predicts recurrence in gastric cancer and the efficacy of immune checkpoint inhibitors in non-small cell lung cancer

Author

Ando, Fumihiko, primary, Kashiwada, Takeru, additional, Kuroda, Shoko, additional, Fujii, Takenori, additional, Takano, Ryotaro, additional, Miyabe, Yoshishige, additional, Kunugi, Shinobu, additional, Sakatani, Takashi, additional, Miyanaga, Akihiko, additional, Asatsuma-Okumura, Tomoko, additional, Hashiguchi, Masaaki, additional, Kanazawa, Yoshikazu, additional, Ohashi, Ryuji, additional, Yoshida, Hiroshi, additional, Seike, Masahiro, additional, Gemma, Akihiko, additional, and Iwai, Yoshiko, additional

Published
2024
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4. Interleukin 21 promotes IgG1+ plasma cell differentiation instead of class switching to IgE via Blimp1 expression.

Author

Hashiguchi, Masaaki, Asatsuma‐Okumura, Tomoko, and Iwai, Yoshiko

Subjects
PLASMA cells, B cell differentiation, T helper cells, IMMUNOGLOBULIN class switching, CELL populations, IMMUNOGLOBULIN E, OVALBUMINS
Abstract

This article, published in the European Journal of Immunology, explores the role of interleukin 21 (IL-21) in the differentiation of plasma cells and the inhibition of IgE expression. The study found that IL-21 promotes the differentiation of IgG1+ plasma cells instead of class switching to IgE by inducing the expression of Blimp1. The researchers demonstrated this through experiments using B cells and mice, showing that IL-21 inhibits the generation of IgE+ cells and promotes the differentiation of IgG1+ plasma cells. These findings suggest that IL-21 plays a role in regulating the production of IgE and may have implications for understanding allergic reactions and asthma. [Extracted from the article]

Published
2024
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5. Clinical significance of PD-1-binding soluble PD-L1 and MMPs in the microenvironment of gastric cancer and non-small cell lung cancer treated with PD-1/PD-L1 blockade

Author

Ando, Fumihiko, primary, Kashiwada, Takeru, additional, Kuroda, Shoko, additional, Fujii, Takenori, additional, Takano, Ryotaro, additional, Miyabe, Yoshishige, additional, Sakatani, Takashi, additional, Asatsuma-Okumura, Tomoko, additional, Hashiguchi, Masaaki, additional, Kanazawa, Yoshikazu, additional, Ohashi, Ryuji, additional, Yoshida, Hiroshi, additional, Seike, Masahiro, additional, Gemma, Akihiko, additional, and Iwai, Yoshiko, additional

Published
2024
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11. Paroxysmal vertigo with nystagmus in children

Author

Okumura, Tomoko, Imai, Takao, Higashi-Shingai, Kayoko, Ohta, Yumi, Morihana, Tetsuo, Sato, Takashi, Okazaki, Suzuyo, Iwamoto, Yoriko, Hanada, Yukiko, Ozono, Yoshiyuki, Imai, Ryusuke, Ohata, Kazuya, and Inohara, Hidenori

Published
2016
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21. Change in endolymphatic hydrops 2 years after endolymphatic sac surgery evaluated by MRI

Author

Higashi-Shingai, Kayoko, primary, Imai, Takao, additional, Okumura, Tomoko, additional, Uno, Atsuhiko, additional, Kitahara, Tadashi, additional, Horii, Arata, additional, Ohta, Yumi, additional, Osaki, Yasuhiro, additional, Sato, Takashi, additional, Okazaki, Suzuyo, additional, Kamakura, Takefumi, additional, Takimoto, Yasumitsu, additional, Ozono, Yoshiyuki, additional, Watanabe, Yoshiyuki, additional, Imai, Ryusuke, additional, Hanada, Yukiko, additional, Ohata, Kazuya, additional, Oya, Ryohei, additional, and Inohara, Hidenori, additional

Published
2020
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24. Effects of Interval Time of the Epley Maneuver on Immediate Reduction of Positional Nystagmus : A Randomized, Controlled, Non-blinded Clinical Trial

Author

Imai, Takao, Okumura, Tomoko, Sato, Takashi, Takeda, Noriaki, Ohta, Yumi, Okazaki, Suzuyo, Inohara, Hidenori, Imai, Takao, Okumura, Tomoko, Sato, Takashi, Takeda, Noriaki, Ohta, Yumi, Okazaki, Suzuyo, and Inohara, Hidenori

Abstract

Objective: The Epley maneuver (EM) has an immediate effect: rapid reduction of positional nystagmus. Benign paroxysmal positional vertigo (BPPV) causes BPPV fatigue, which constitutes fatigability of positional nystagmus and vertigo with repeated performance of the Dix-Hallpike test; notably, BPPV fatigability becomes ineffective over time. We hypothesized that the immediate effect of the EM is caused by BPPV fatigue. Therefore, we suspected that performance of the EM with intervals between head positions would worsen the immediate reduction of positional nystagmus in patients with BPPV, because BPPV fatigability would become ineffective during performance of this therapy. Methods: Forty patients with newly diagnosed BPPV were randomly assigned to the following two groups; one group performed the EM without intervals between positions (group A), and the other group performed the EM with 3 min intervals between positions (group B). The primary outcome measure was the ratio of maximum slow-phase eye velocity (MSPEV) of positional nystagmus soon after the EM, compared with that measured before the EM. Secondary outcome included whether a 30 min interval after the EM enabled recovery of MSPEV of positional nystagmus to the original value. This study followed the CONSORT 2010 reporting standards. Results: In both groups A and B, the immediate effect of the EM could be observed, because MSPEV during the second Dix-Hallpike test was significantly smaller than MSPEV during the first Dix-Hallpike test (p < 0.0001 in group A, p < 0.0001 in group B). The primary outcome measure was larger in group B than in group A (p = 0.0029). The immediate effect faded 30 min later (secondary outcome). Conclusions: This study showed that the EM had an immediate effect both with and without interval time in each head position of the EM. Because setting interval time in each head position of the EM reduced the immediate effect of the EM, interval time during the EM adds less benefit. This fin

Published
2019

27. Change in endolymphatic hydrops 2 years after endolymphatic sac surgery evaluated by MRI

Author

Higashi-Shingai, Kayoko, primary, Imai, Takao, additional, Okumura, Tomoko, additional, Uno, Atsuhiko, additional, Kitahara, Tadashi, additional, Horii, Arata, additional, Ohta, Yumi, additional, Osaki, Yasuhiro, additional, Sato, Takashi, additional, Okazaki, Suzuyo, additional, Kamakura, Takefumi, additional, Takimoto, Yasumitsu, additional, Ozono, Yoshiyuki, additional, Watanabe, Yoshiyuki, additional, Imai, Ryusuke, additional, Hanada, Yukiko, additional, Ohata, Kazuya, additional, Oya, Ryohei, additional, and Inohara, Hidenori, additional

Published
2019
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30. Visual Target Strategies in Infantile Nystagmus Patients With Horizontal Jerk Waveform

Author

Imai, Takao, Takimoto, Yasumitsu, Okumura, Tomoko, Higashi-Shingai, Kayoko, Takeda, Noriaki, Kitamura, Koji, Kalubi, Bukasa, Fujikado, Takashi, Hirota, Masakazu, Midoh, Yoshihiro, Nakamae, Koji, Inohara, Hidenori, Imai, Takao, Takimoto, Yasumitsu, Okumura, Tomoko, Higashi-Shingai, Kayoko, Takeda, Noriaki, Kitamura, Koji, Kalubi, Bukasa, Fujikado, Takashi, Hirota, Masakazu, Midoh, Yoshihiro, Nakamae, Koji, and Inohara, Hidenori

Abstract

The aim of this study was to propose a new pathophysiological hypothesis for involuntary eye oscillation in infantile nystagmus (IN): patients with IN exhibit impaired gaze fixation, horizontal smooth pursuit and optokinetic nystagmus (OKN) and use saccadic eye movements for these underlying impairments. In order to induce saccades, they make enough angle between gaze and target by precedent exponential slow eye movements. IN consists of the alternate appearance of the saccade and the slow eye movements. Unlike most previous theories, IN is therefore considered a necessary strategy allowing for better vision and not an obstacle to clear vision. In five patients with IN, eye movements were analyzed during the smooth pursuit test, saccadic eye movement test, OKN test and vestibulo-ocular reflex (VOR) test. Their gaze fixation, horizontal smooth pursuit, OKN and the last half of the slow phase of VOR were impaired. The lines obtained by connection of the end eye positions of fast phase of nystagmus coincided with the trajectories of targets. The findings indicate that patients followed the target by the fast but not the slow phase of nystagmus, which supports our hypothesis. By setting the direction of slow phase of nystagmus opposite to the direction of the OKN stimulation, enough angle can be effectively made between the gaze and target for the induction of saccade. This is the mechanism of reversed OKN response. In darkness and when eyes are closed, IN weakens because there is no visual target and neither the saccade for catching up the target or slow phase for induction of the saccade is needed.

Published
2018

32. The Transcript-ratios of CD3 Subunits of Mouse

Author

Okabe, Yumi, Okumura, Tomoko, Kazami, Sachiko, Sasagawa, Marie, and Miyata, Kenji

Subjects
転写, マウス, CD3, リアルタイムPCR
Abstract

The transcripts of T cell receptor β chain（TCRβ） and CD3 subunits, CD3γ, CD3δ and CD3ε, were detected through realtime PCR in thymus and spleen of BALB/c female mouse from neonates to 400 days. The logarithmic transcript-ratios of logCD3γ/TCRβ and logCD3δ

Published
2014

36. ARID2 is a pomalidomide-dependent CRL4CRBNsubstrate in multiple myeloma cells

Author

Yamamoto, Junichi, Suwa, Tetsufumi, Murase, Yuki, Tateno, Shumpei, Mizutome, Hirotaka, Asatsuma-Okumura, Tomoko, Shimizu, Nobuyuki, Kishi, Tsutomu, Momose, Shuji, Kizaki, Masahiro, Ito, Takumi, Yamaguchi, Yuki, and Handa, Hiroshi

Abstract

The immunomodulatory drug (IMiD) thalidomide and its derivatives lenalidomide and pomalidomide are therapeutic agents used in the treatment of multiple myeloma. Although pomalidomide offers considerable clinical benefits to patients with lenalidomide-resistant multiple myeloma, the molecular mechanisms underlying its superior efficacy remain unclear. Here we show that ARID2, a component of the polybromo-associated BAF (PBAF) chromatin-remodeling complex, is a pomalidomide-induced neosubstrate of CRL4CRBN. BRD7, another subunit of PBAF, is critical for pomalidomide-induced ARID2 degradation. ARID2 is involved in transcriptional regulation of pomalidomide target genes including MYC. Pomalidomide is more effective than lenalidomide in degrading ARID2 and is capable of inhibiting MYCexpression and proliferation in lenalidomide-resistant cell lines. Notably, ARID2 expression is associated with a poor prognosis and is higher in chemoresistant minimal residual disease (MRD) populations, and in patients with relapsed/refractory multiple myeloma. These findings suggest that ARID2 is a promising target for overcoming lenalidomide resistance in patients with multiple myeloma.

Published
2020
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45. A case of Arnold-Chiari malformation showing bow-tie nystagmus

Author

Iwamoto, Yoriko, primary, Imai, Takao, additional, Okumura, Tomoko, additional, Shingai, Kayoko, additional, Horii, Arata, additional, Uno, Atsuhiko, additional, Nishiike, Suetaka, additional, Ohta, Yumi, additional, Morihana, Tetsuo, additional, Masumura, Chisako, additional, Kamakura, Takefumi, additional, Takimoto, Yasumitsu, additional, Ozono, Yoshiyuki, additional, Hanada, Yukiko, additional, and Inohara, Hidenori, additional

Published
2015
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