Interleukin 21 promotes IgG1+ plasma cell differentiation instead of class switching to IgE via Blimp1 expression.

This article, published in the European Journal of Immunology, explores the role of interleukin 21 (IL-21) in the differentiation of plasma cells and the inhibition of IgE expression. The study found that IL-21 promotes the differentiation of IgG1+ plasma cells instead of class switching to IgE by inducing the expression of Blimp1. The researchers demonstrated this through experiments using B cells and mice, showing that IL-21 inhibits the generation of IgE+ cells and promotes the differentiation of IgG1+ plasma cells. These findings suggest that IL-21 plays a role in regulating the production of IgE and may have implications for understanding allergic reactions and asthma. [Extracted from the article]