474 results on '"Okbay A"'
Search Results
2. Shared genetic architectures of educational attainment in East Asian and European populations
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Chen, Tzu-Ting, Kim, Jaeyoung, Lam, Max, Chuang, Yi-Fang, Chiu, Yen-Ling, Lin, Shu-Chin, Jung, Sang-Hyuk, Kim, Beomsu, Kim, Soyeon, Cho, Chamlee, Shim, Injeong, Park, Sanghyeon, Ahn, Yeeun, Okbay, Aysu, Jang, Hyemin, Kim, Hee Jin, Seo, Sang Won, Park, Woong-Yang, Ge, Tian, Huang, Hailiang, Feng, Yen-Chen Anne, Lin, Yen-Feng, Myung, Woojae, Chen, Chia-Yen, and Won, Hong-Hee
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- 2024
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3. Otomatik Meibomian Bezi ve Göz Kapağı Bölütlemesi.
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öykü Diribas, Volkan Okbay, Onat Akça, ömer Mustafa Bilgiç, Nilüfer Yesilirmak, and Gözde Bozdagi Akar
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- 2024
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4. Self-control is associated with health-relevant disparities in buccal DNA-methylation measures of biological aging in older adults
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Y. E. Willems, A. deSteiguer, P. T. Tanksley, L. Vinnik, D. Fraemke, A. Okbay, D. Richter, G. G. Wagner, R. Hertwig, P. Koellinger, E. M. Tucker-Drob, K. P. Harden, and Laurel Raffington
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Self-control ,DNA-methylation ,Pace of aging ,Biological aging ,Health ,Life span ,Medicine ,Genetics ,QH426-470 - Abstract
Abstract Self-control is a personality dimension that is associated with better physical health and a longer lifespan. Here, we examined (1) whether self-control is associated with buccal and saliva DNA-methylation (DNAm) measures of biological aging quantified in children, adolescents, and adults, and (2) whether biological aging measured in buccal DNAm is associated with self-reported health. Following preregistered analyses, we computed two DNAm measures of advanced biological age (principal-component PhenoAge and GrimAge Acceleration) and a DNAm measure of pace of aging (DunedinPACE) in buccal samples from the German Socioeconomic Panel Study (SOEP-G[ene], n = 1058, age range 0–72, M age = 42.65) and saliva samples from the Texas Twin Project (TTP, n = 1327, age range 8–20, M age = 13.50). We found that lower self-control was associated with advanced biological age in older adults (PhenoAge Acceleration β = − .34, [− .51, − .17], p
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- 2024
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5. Multivariate GWAS of psychiatric disorders and their cardinal symptoms reveal two dimensions of cross-cutting genetic liabilities
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Mallard, Travis T, Linnér, Richard Karlsson, Grotzinger, Andrew D, Sanchez-Roige, Sandra, Seidlitz, Jakob, Okbay, Aysu, de Vlaming, Ronald, Meddens, S Fleur W, Consortium, Bipolar Disorder Working Group of the Psychiatric Genomics, Palmer, Abraham A, Davis, Lea K, Tucker-Drob, Elliot M, Kendler, Kenneth S, Keller, Matthew C, Koellinger, Philipp D, and Harden, K Paige
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Biological Psychology ,Biological Sciences ,Genetics ,Psychology ,Behavioral and Social Science ,Brain Disorders ,Depression ,Schizophrenia ,Mental Health ,Human Genome ,Mental Illness ,Serious Mental Illness ,Neurosciences ,2.1 Biological and endogenous factors ,2.3 Psychological ,social and economic factors ,Mental health ,Good Health and Well Being ,Bipolar Disorder Working Group of the Psychiatric Genomics Consortium - Abstract
Understanding which biological pathways are specific versus general across diagnostic categories and levels of symptom severity is critical to improving nosology and treatment of psychopathology. Here, we combine transdiagnostic and dimensional approaches to genetic discovery for the first time, conducting a novel multivariate genome-wide association study of eight psychiatric symptoms and disorders broadly related to mood disturbance and psychosis. We identify two transdiagnostic genetic liabilities that distinguish between common forms of psychopathology versus rarer forms of serious mental illness. Biological annotation revealed divergent genetic architectures that differentially implicated prenatal neurodevelopment and neuronal function and regulation. These findings inform psychiatric nosology and biological models of psychopathology, as they suggest that the severity of mood and psychotic symptoms present in serious mental illness may reflect a difference in kind rather than merely in degree.
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- 2022
6. Mendelian imputation of parental genotypes improves estimates of direct genetic effects
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Young, Alexander I, Nehzati, Seyed Moeen, Benonisdottir, Stefania, Okbay, Aysu, Jayashankar, Hariharan, Lee, Chanwook, Cesarini, David, Benjamin, Daniel J, Turley, Patrick, and Kong, Augustine
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Biological Sciences ,Genetics ,Human Genome ,Aetiology ,2.1 Biological and endogenous factors ,Generic health relevance ,Genome-Wide Association Study ,Genotype ,Humans ,Parents ,Polymorphism ,Single Nucleotide ,Software ,Medical and Health Sciences ,Developmental Biology ,Agricultural biotechnology ,Bioinformatics and computational biology - Abstract
Effects estimated by genome-wide association studies (GWASs) include effects of alleles in an individual on that individual (direct genetic effects), indirect genetic effects (for example, effects of alleles in parents on offspring through the environment) and bias from confounding. Within-family genetic variation is random, enabling unbiased estimation of direct genetic effects when parents are genotyped. However, parental genotypes are often missing. We introduce a method that imputes missing parental genotypes and estimates direct genetic effects. Our method, implemented in the software package snipar (single-nucleotide imputation of parents), gives more precise estimates of direct genetic effects than existing approaches. Using 39,614 individuals from the UK Biobank with at least one genotyped sibling/parent, we estimate the correlation between direct genetic effects and effects from standard GWASs for nine phenotypes, including educational attainment (r = 0.739, standard error (s.e.) = 0.086) and cognitive ability (r = 0.490, s.e. = 0.086). Our results demonstrate substantial confounding bias in standard GWASs for some phenotypes.
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- 2022
7. Polygenic prediction of educational attainment within and between families from genome-wide association analyses in 3 million individuals
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Okbay, Aysu, Wu, Yeda, Wang, Nancy, Jayashankar, Hariharan, Bennett, Michael, Nehzati, Seyed Moeen, Sidorenko, Julia, Kweon, Hyeokmoon, Goldman, Grant, Gjorgjieva, Tamara, Jiang, Yunxuan, Hicks, Barry, Tian, Chao, Hinds, David A, Ahlskog, Rafael, Magnusson, Patrik KE, Oskarsson, Sven, Hayward, Caroline, Campbell, Archie, Porteous, David J, Freese, Jeremy, Herd, Pamela, Watson, Chelsea, Jala, Jonathan, Conley, Dalton, Koellinger, Philipp D, Johannesson, Magnus, Laibson, David, Meyer, Michelle N, Lee, James J, Kong, Augustine, Yengo, Loic, Cesarini, David, Turley, Patrick, Visscher, Peter M, Beauchamp, Jonathan P, Benjamin, Daniel J, and Young, Alexander I
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Human Genome ,Genetics ,Pediatric ,Aetiology ,2.1 Biological and endogenous factors ,Genome-Wide Association Study ,Humans ,Multifactorial Inheritance ,Polymorphism ,Single Nucleotide ,23andMe Research Team ,Social Science Genetic Association Consortium ,Biological Sciences ,Medical and Health Sciences ,Developmental Biology - Abstract
We conduct a genome-wide association study (GWAS) of educational attainment (EA) in a sample of ~3 million individuals and identify 3,952 approximately uncorrelated genome-wide-significant single-nucleotide polymorphisms (SNPs). A genome-wide polygenic predictor, or polygenic index (PGI), explains 12-16% of EA variance and contributes to risk prediction for ten diseases. Direct effects (i.e., controlling for parental PGIs) explain roughly half the PGI's magnitude of association with EA and other phenotypes. The correlation between mate-pair PGIs is far too large to be consistent with phenotypic assortment alone, implying additional assortment on PGI-associated factors. In an additional GWAS of dominance deviations from the additive model, we identify no genome-wide-significant SNPs, and a separate X-chromosome additive GWAS identifies 57.
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- 2022
8. Resource profile and user guide of the Polygenic Index Repository
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Becker, Joel, Burik, Casper AP, Goldman, Grant, Wang, Nancy, Jayashankar, Hariharan, Bennett, Michael, Belsky, Daniel W, Karlsson Linnér, Richard, Ahlskog, Rafael, Kleinman, Aaron, Hinds, David A, Caspi, Avshalom, Corcoran, David L, Moffitt, Terrie E, Poulton, Richie, Sugden, Karen, Williams, Benjamin S, Harris, Kathleen Mullan, Steptoe, Andrew, Ajnakina, Olesya, Milani, Lili, Esko, Tõnu, Iacono, William G, McGue, Matt, Magnusson, Patrik KE, Mallard, Travis T, Harden, K Paige, Tucker-Drob, Elliot M, Herd, Pamela, Freese, Jeremy, Young, Alexander, Beauchamp, Jonathan P, Koellinger, Philipp D, Oskarsson, Sven, Johannesson, Magnus, Visscher, Peter M, Meyer, Michelle N, Laibson, David, Cesarini, David, Benjamin, Daniel J, Turley, Patrick, and Okbay, Aysu
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Epidemiology ,Health Sciences ,2.6 Resources and infrastructure (aetiology) ,Aetiology ,Data Analysis ,Databases ,Genetic ,Genome-Wide Association Study ,Humans ,Multifactorial Inheritance ,Polymorphism ,Single Nucleotide ,Polygenic score ,Polygenic index ,Repository ,Measurement error ,23andMe Research Group ,Biomedical and clinical sciences ,Health sciences ,Psychology - Abstract
Polygenic indexes (PGIs) are DNA-based predictors. Their value for research in many scientific disciplines is growing rapidly. As a resource for researchers, we used a consistent methodology to construct PGIs for 47 phenotypes in 11 datasets. To maximize the PGIs' prediction accuracies, we constructed them using genome-wide association studies-some not previously published-from multiple data sources, including 23andMe and UK Biobank. We present a theoretical framework to help interpret analyses involving PGIs. A key insight is that a PGI can be understood as an unbiased but noisy measure of a latent variable we call the 'additive SNP factor'. Regressions in which the true regressor is this factor but the PGI is used as its proxy therefore suffer from errors-in-variables bias. We derive an estimator that corrects for the bias, illustrate the correction, and make a Python tool for implementing it publicly available.
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- 2021
9. Genomic analysis of diet composition finds novel loci and associations with health and lifestyle
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Meddens, S Fleur W, de Vlaming, Ronald, Bowers, Peter, Burik, Casper AP, Linnér, Richard Karlsson, Lee, Chanwook, Okbay, Aysu, Turley, Patrick, Rietveld, Cornelius A, Fontana, Mark Alan, Ghanbari, Mohsen, Imamura, Fumiaki, McMahon, George, van der Most, Peter J, Voortman, Trudy, Wade, Kaitlin H, Anderson, Emma L, Braun, Kim VE, Emmett, Pauline M, Esko, Tonũ, Gonzalez, Juan R, Kiefte-de Jong, Jessica C, Langenberg, Claudia, Luan, Jian’an, Muka, Taulant, Ring, Susan, Rivadeneira, Fernando, Snieder, Harold, van Rooij, Frank JA, Wolffenbuttel, Bruce HR, Smith, George Davey, Franco, Oscar H, Forouhi, Nita G, Ikram, M Arfan, Uitterlinden, Andre G, van Vliet-Ostaptchouk, Jana V, Wareham, Nick J, Cesarini, David, Harden, K Paige, Lee, James J, Benjamin, Daniel J, Chow, Carson C, and Koellinger, Philipp D
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Biomedical and Clinical Sciences ,Nutrition and Dietetics ,Prevention ,Behavioral and Social Science ,Genetics ,Obesity ,Human Genome ,Nutrition ,Diabetes ,Aetiology ,2.1 Biological and endogenous factors ,Cardiovascular ,Metabolic and endocrine ,Body Mass Index ,Diabetes Mellitus ,Type 2 ,Diet ,Genome-Wide Association Study ,Genomics ,Humans ,Life Style ,23andMe Research Team ,EPIC- InterAct Consortium ,Lifelines Cohort Study ,Biological Sciences ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Psychiatry ,Clinical sciences ,Biological psychology ,Clinical and health psychology - Abstract
We conducted genome-wide association studies (GWAS) of relative intake from the macronutrients fat, protein, carbohydrates, and sugar in over 235,000 individuals of European ancestries. We identified 21 unique, approximately independent lead SNPs. Fourteen lead SNPs are uniquely associated with one macronutrient at genome-wide significance (P
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- 2021
10. The Usability of Platelet Mass Index Thresholds to Assess the Repeated Platelet Transfusion Requirements in Neonates
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Okbay Gunes, Asli, Geter, Suleyman, and Avlanmis, Mehmet Emin
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- 2022
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11. Comparative Outcomes of Levetiracetam and Phenobarbital Usage in the Treatment of Neonatal Seizures: A Retrospective Analysis
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Handan Hakyemez Toptan, Nazmiye Nilgun Karadag, Sevilay Topcuoglu, Elif Ozalkaya, Emre Dincer, Hakan Cakir, Asli Okbay Gunes, and Guner Karatekin
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neonatal seizures ,phenobarbital ,levetiracetam ,adverse events ,safety profile ,mortality rate ,Medicine - Abstract
Objectives and Aim: The primary aim of this study was to conduct a comparative analysis of the safety and efficacy of levetiracetam (LEV) and phenobarbital (PB) as first-line treatments for neonatal seizure management. This study was designed to measure and compare the incidence of adverse effects and to determine the discharge and mortality rates associated with the use of these antiseizure medications (ASMs). Through this comparison, this research sought to provide insights to optimise care for neonates experiencing seizures. Materials and Methods: This retrospective cohort study evaluated 104 neonates treated for seizures at Zeynep Kamil Hospital from 2015 to 2020 after excluding those on non-PB/LEV antiseizure medications. Seizures were characterised using electroencephalogram (EEG) and categorised according to aetiology and frequency. Treatment efficacy was gauged by seizure cessation, as confirmed using EEG. Adverse effects and demographic data were recorded. Statistical analyses were conducted using SPSS, employing the Shapiro–Wilk, independent t-test, Mann–Whitney U test, and chi-square test, with a significance threshold of p < 0.05. Results: Overall, 104 neonates treated with first-line ASM were evaluated for efficacy; PB was administered in 68.26% of the cases, while LEV was utilised in 31.74%. The total complete response rate was 40.38%, with no significant difference between the PB and LEV groups (p = 0.309). The incidence rate ratios (IRRs) demonstrated that seizure frequency profoundly influenced treatment effectiveness, with IRRs of 2.09 for rare seizures, 3.25 for frequent seizures, and 4.01 for status epilepticus, indicating a higher treatment response rate with increasing seizure frequency. For second-line treatment, among a subset of 62 patients, PB had a slight, non-significant advantage over LEV, with an odds ratio of 1.09, suggesting a marginally better response to LEV. Adverse events were significantly more frequent in the PB group, affecting 19 of 67 neonates (28.36%), compared to only 2 of 71 neonates (2.82%) in the LEV group (p < 0.001). No significant difference was observed in the discharge rates between the two groups (PB, 67.61%; LEV, 75.76%; p = 0.674). Interestingly, the mortality rate was significantly higher in the LEV group (45.45%) than that in the PB group (22.54%; p = 0.045). Conclusion: This study underscores LEV’s superior safety profile over PB in neonatal seizure management, evidenced by a significantly lower rate of adverse events. PB seems to be more effective in the second-line treatment of neonatal seizures. Despite the lack of significant differences in the discharge rates, the higher mortality rate associated with LEV warrants further investigation. These findings advocate the cautious selection of antiepileptic drugs in neonatal care, with a preference for LEV based on its safety profile.
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- 2024
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12. A polygenic score for educational attainment partially predicts voter turnout
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Dawes, Christopher T., Okbay, Aysu, Oskarsson, Sven, and Rustichini, Aldo
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- 2021
13. Shared genetic architectures of subjective well-being in East Asian and European ancestry populations
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Kim, Soyeon, Kim, Kiwon, Hwang, Mi Yeong, Ko, Hyunwoong, Jung, Sang-Hyuk, Shim, Injeong, Cha, Soojin, Lee, Hyewon, Kim, Beomsu, Yoon, Joohyun, Ha, Tae Hyon, Kim, Doh Kwan, Kim, Jinho, Park, Woong-Yang, Okbay, Aysu, Kim, Bong-Jo, Kim, Young Jin, Myung, Woojae, and Won, Hong-Hee
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- 2022
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14. Biodiversity of syrphid fly (order Diptera, Family Syrphidae) in Hamelmalo Agriculture College, State of Eritrea
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Ahmad, Tufail, Haile, Adugna, Okbay, Eden Okbaghergs, Fisehaye, Rigat Mogos, Eyasu, Ataklti Okube, Berhe, Feruz Habteab, and Ghebrebrhan, Niat Abraham
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- 2022
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15. The Association Between Hypoxic–Ischemic Encephalopathy and Thyroid Hormones.
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Okbay Gunes, Asli and Bozkaya, Aydin
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- 2024
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16. The future of human behaviour research
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Box-Steffensmeier, Janet M., Burgess, Jean, Corbetta, Maurizio, Crawford, Kate, Duflo, Esther, Fogarty, Laurel, Gopnik, Alison, Hanafi, Sari, Herrero, Mario, Hong, Ying-yi, Kameyama, Yasuko, Lee, Tatia M. C., Leung, Gabriel M., Nagin, Daniel S., Nobre, Anna C., Nordentoft, Merete, Okbay, Aysu, Perfors, Andrew, Rival, Laura M., Sugimoto, Cassidy R., Tungodden, Bertil, and Wagner, Claudia
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- 2022
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17. Cohort profile: Genetic data in the German Socio-Economic Panel Innovation Sample (SOEP-G)
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Philipp D. Koellinger, Aysu Okbay, Hyeokmoon Kweon, Annemarie Schweinert, Richard Karlsson Linnér, Jan Goebel, David Richte, Lisa Reiber, Bettina Maria Zweck, Daniel W. Belsky, Pietro Biroli, Rui Mata, Elliot M. Tucker-Drob, K. Paige Harden, Gert Wagner, and Ralph Hertwig
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Medicine ,Science - Published
- 2023
18. Multi-trait analysis of genome-wide association summary statistics using MTAG
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Turley, Patrick, Walters, Raymond K, Maghzian, Omeed, Okbay, Aysu, Lee, James J, Fontana, Mark Alan, Nguyen-Viet, Tuan Anh, Wedow, Robbee, Zacher, Meghan, Furlotte, Nicholas A, 23andMe Research Team, Social Science Genetic Association Consortium, Magnusson, Patrik, Oskarsson, Sven, Johannesson, Magnus, Visscher, Peter M, Laibson, David, Cesarini, David, Neale, Benjamin M, and Benjamin, Daniel J
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Biological Sciences ,Genetics ,Human Genome ,Algorithms ,Data Interpretation ,Statistical ,Datasets as Topic ,Depression ,Diagnostic Self Evaluation ,Genetic Association Studies ,Genome-Wide Association Study ,Health ,Humans ,Meta-Analysis as Topic ,Multifactorial Inheritance ,Neuroticism ,Phenotype ,Polymorphism ,Single Nucleotide ,Quantitative Trait Loci ,23andMe Research Team ,Social Science Genetic Association Consortium ,Medical and Health Sciences ,Developmental Biology ,Agricultural biotechnology ,Bioinformatics and computational biology - Abstract
We introduce multi-trait analysis of GWAS (MTAG), a method for joint analysis of summary statistics from genome-wide association studies (GWAS) of different traits, possibly from overlapping samples. We apply MTAG to summary statistics for depressive symptoms (N eff = 354,862), neuroticism (N = 168,105), and subjective well-being (N = 388,538). As compared to the 32, 9, and 13 genome-wide significant loci identified in the single-trait GWAS (most of which are themselves novel), MTAG increases the number of associated loci to 64, 37, and 49, respectively. Moreover, association statistics from MTAG yield more informative bioinformatics analyses and increase the variance explained by polygenic scores by approximately 25%, matching theoretical expectations.
- Published
- 2018
19. Differences in polygenic associations with educational attainment between West and East Germany before and after reunification
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Fraemke, D., primary, Willems, Y.E., additional, Okbay, A., additional, Wagner, G., additional, Tucker-Drob, E.M., additional, Harden, K.P., additional, Hertwig, R., additional, Koellinger, P., additional, and Raffington, L., additional
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- 2024
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20. Polygenic transmission disequilibrium confirms that common and rare variation act additively to create risk for autism spectrum disorders
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Weiner, Daniel J, Wigdor, Emilie M, Ripke, Stephan, Walters, Raymond K, Kosmicki, Jack A, Grove, Jakob, Samocha, Kaitlin E, Goldstein, Jacqueline I, Okbay, Aysu, Bybjerg-Grauholm, Jonas, Werge, Thomas, Hougaard, David M, Taylor, Jacob, Skuse, David, Devlin, Bernie, Anney, Richard, Sanders, Stephan J, Bishop, Somer, Mortensen, Preben Bo, Børglum, Anders D, Smith, George Davey, Daly, Mark J, and Robinson, Elise B
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Biological Sciences ,Genetics ,Autism ,Brain Disorders ,Prevention ,Mental Health ,Pediatric ,Intellectual and Developmental Disabilities (IDD) ,2.4 Surveillance and distribution ,Aetiology ,2.1 Biological and endogenous factors ,Mental health ,Good Health and Well Being ,Adult ,Autism Spectrum Disorder ,Child ,Cohort Studies ,Educational Status ,Ethnicity ,Family Health ,Female ,Genetic Association Studies ,Genetic Predisposition to Disease ,Genetic Variation ,Genetics ,Behavioral ,Humans ,Intellectual Disability ,Intelligence ,Male ,Multifactorial Inheritance ,Phenotype ,Risk Factors ,Schizophrenia ,Sequence Deletion ,iPSYCH-Broad Autism Group ,Psychiatric Genomics Consortium Autism Group ,Medical and Health Sciences ,Developmental Biology ,Agricultural biotechnology ,Bioinformatics and computational biology - Abstract
Autism spectrum disorder (ASD) risk is influenced by common polygenic and de novo variation. We aimed to clarify the influence of polygenic risk for ASD and to identify subgroups of ASD cases, including those with strongly acting de novo variants, in which polygenic risk is relevant. Using a novel approach called the polygenic transmission disequilibrium test and data from 6,454 families with a child with ASD, we show that polygenic risk for ASD, schizophrenia, and greater educational attainment is over-transmitted to children with ASD. These findings hold independent of proband IQ. We find that polygenic variation contributes additively to risk in ASD cases who carry a strongly acting de novo variant. Lastly, we show that elements of polygenic risk are independent and differ in their relationship with phenotype. These results confirm that the genetic influences on ASD are additive and suggest that they create risk through at least partially distinct etiologic pathways.
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- 2017
21. The association between separation individuation process and binge eating disorder in adolescents aged 12–18
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Sen Demirdogen, Ezgi, Algedik, Pinar, Kadak, Muhammed Tayyip, Alikasifoglu, Mujgan, Okbay Gunes, Asli, and Demir, Turkay
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- 2021
- Full Text
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22. Multivariate GWAS of psychiatric disorders and their cardinal symptoms reveal two dimensions of cross-cutting genetic liabilities
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Travis T. Mallard, Richard Karlsson Linnér, Andrew D. Grotzinger, Sandra Sanchez-Roige, Jakob Seidlitz, Aysu Okbay, Ronald de Vlaming, S. Fleur W. Meddens, Abraham A. Palmer, Lea K. Davis, Elliot M. Tucker-Drob, Kenneth S. Kendler, Matthew C. Keller, Philipp D. Koellinger, and K. Paige Harden
- Subjects
psychiatric genetics ,psychiatric disorders ,transdiagnostic ,genome-wide association study ,genetic correlation ,pleiotropy ,Genetics ,QH426-470 ,Internal medicine ,RC31-1245 - Abstract
Summary: Understanding which biological pathways are specific versus general across diagnostic categories and levels of symptom severity is critical to improving nosology and treatment of psychopathology. Here, we combine transdiagnostic and dimensional approaches to genetic discovery for the first time, conducting a novel multivariate genome-wide association study of eight psychiatric symptoms and disorders broadly related to mood disturbance and psychosis. We identify two transdiagnostic genetic liabilities that distinguish between common forms of psychopathology versus rarer forms of serious mental illness. Biological annotation revealed divergent genetic architectures that differentially implicated prenatal neurodevelopment and neuronal function and regulation. These findings inform psychiatric nosology and biological models of psychopathology, as they suggest that the severity of mood and psychotic symptoms present in serious mental illness may reflect a difference in kind rather than merely in degree.
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- 2022
- Full Text
- View/download PDF
23. Factors Associated with Post-rewarming Procalcitonin Levels in Newborns with Hypoxic Ischemic Encephalopathy.
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Güneş, Aslı Okbay, Bozkaya, Aydın, and Avlanmis, Mehmet Emin
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CROSS-sectional method , *CEREBRAL anoxia-ischemia , *ACADEMIC medical centers , *T-test (Statistics) , *THERMOTHERAPY , *LOGISTIC regression analysis , *ELECTROENCEPHALOGRAPHY , *NEONATAL intensive care units , *CALCITONIN , *TREATMENT effectiveness , *DESCRIPTIVE statistics , *RETROSPECTIVE studies , *NEONATAL intensive care , *MANN Whitney U Test , *GESTATIONAL age , *COMPARATIVE studies , *DATA analysis software , *CHILDREN - Abstract
Objective: To determine the factors associated with the procalcitonin levels in newborns with hypoxic-ischemic encephalopathy (HIE) who received therapeutic hypothermia (TH). Materials and Methods: The neonates, who had moderate/severe HIE and were treated with TH, were included. The neonates were arranged into 2 groups by procalcitonin (PCT) level after rewarming was completed. The neonates who had a procalcitonin level of < 2.5 ng/ml constituted Group 1 and the ones who had a procalcitonin level of ≥ 2.5 ng/ml constituted Group 2. Univariate and multivariate logistic regression was used to assess the factors related with PCT level. Results: The first group included 123 (87.9%) neonates and the second group included 17 (12.1%) neonates. The median gestational age was 38 (36-39) weeks and the mean birth weight was 3081.7 ± 552.8 grams. In group 2, the rates for severe HIE, cesarean section, antibiotic switch, convulsion, inotrope use and mortality were higher, and duration of hospitalization was longer, whereas Apgar scores were lower (P < .05). The risk of a high procalcitonin level was found to be 6-fold (95% CI 1.9-19.1) higher in severe HIE and 5.2-fold higher (95% CI 1.7-16) in cesarean delivery. Conclusion: In neonates with HIE/TH, high post-rewarming procalcitonin levels were related with severe HIE and cesarean delivery. Some other clinical and laboratory findings, which may reflect worse clinical status, were also associated with high procalcitonin levels. [ABSTRACT FROM AUTHOR]
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- 2024
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24. Educational attainment polygenic scores are associated with cortical total surface area and regions important for language and memory
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Mitchell, Brittany L., Cuéllar-Partida, Gabriel, Grasby, Katrina L., Campos, Adrian I., Strike, Lachlan T., Hwang, Liang-Dar, Okbay, Aysu, Thompson, Paul M., Medland, Sarah E., Martin, Nicholas G., Wright, Margaret J., and Rentería, Miguel E.
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- 2020
- Full Text
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25. Associations between common genetic variants and income provide insights about the socioeconomic health gradient
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Kweon, Hyeokmoon, primary, Burik, Casper A.P., additional, Ning, Yuchen, additional, Ahlskog, Rafael, additional, Xia, Charley, additional, Abner, Erik, additional, Bao, Yanchun, additional, Bhatta, Laxmi, additional, Faquih, Tariq O., additional, de Feijter, Maud, additional, Fisher, Paul, additional, Gelemanović, Andrea, additional, Giannelis, Alexandros, additional, Hottenga, Jouke-Jan, additional, Khalili, Bita, additional, Lee, Yunsung, additional, Li-Gao, Ruifang, additional, Masso, Jaan, additional, Myhre, Ronny, additional, Palviainen, Teemu, additional, Rietveld, Cornelius A., additional, Teumer, Alexander, additional, Verweij, Renske M., additional, Willoughby, Emily A., additional, Agerbo, Esben, additional, Bergmann, Sven, additional, Boomsma, Dorret I., additional, Børglum, Anders D., additional, Brumpton, Ben M., additional, Davies, Neil Martin, additional, Esko, Tõnu, additional, Gordon, Scott D., additional, Homuth, Georg, additional, Ikram, M. Arfan, additional, Johannesson, Magnus, additional, Kaprio, Jaakko, additional, Kidd, Michael P., additional, Kutalik, Zoltán, additional, Kwong, Alex S.F., additional, Lee, James J., additional, Luik, Annemarie I., additional, Magnus, Per, additional, Marques-Vidal, Pedro, additional, Martin, Nicholas G., additional, Mook-Kanamori, Dennis O., additional, Mortensen, Preben Bo, additional, Oskarsson, Sven, additional, Pedersen, Emil M., additional, Polašek, Ozren, additional, Rosendaal, Frits R., additional, Smart, Melissa C., additional, Snieder, Harold, additional, van der Most, Peter J., additional, Vollenweider, Peter, additional, Völzke, Henry, additional, Willemsen, Gonneke, additional, Beauchamp, Jonathan P., additional, DiPrete, Thomas A., additional, Linnér, Richard Karlsson, additional, Lu, Qiongshi, additional, Morris, Tim T., additional, Okbay, Aysu, additional, Harden, K. Paige, additional, Abdellaoui, Abdel, additional, Hill, W. David, additional, de Vlaming, Ronald, additional, Benjamin, Daniel J., additional, and Koellinger, Philipp D., additional
- Published
- 2024
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26. Brains, hormones, and genes: Introduction to the special issue on the biological foundations of economic decision-making
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Fairley, Kim, primary, Fornwagner, Helena, additional, and Okbay, Aysu, additional
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- 2024
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27. Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses
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Okbay, Aysu, Baselmans, Bart ML, De Neve, Jan-Emmanuel, Turley, Patrick, Nivard, Michel G, Fontana, Mark Alan, Meddens, S Fleur W, Linnér, Richard Karlsson, Rietveld, Cornelius A, Derringer, Jaime, Gratten, Jacob, Lee, James J, Liu, Jimmy Z, de Vlaming, Ronald, Ahluwalia, Tarunveer S, Buchwald, Jadwiga, Cavadino, Alana, Frazier-Wood, Alexis C, Furlotte, Nicholas A, Garfield, Victoria, Geisel, Marie Henrike, Gonzalez, Juan R, Haitjema, Saskia, Karlsson, Robert, van der Laan, Sander W, Ladwig, Karl-Heinz, Lahti, Jari, van der Lee, Sven J, Lind, Penelope A, Liu, Tian, Matteson, Lindsay, Mihailov, Evelin, Miller, Michael B, Minica, Camelia C, Nolte, Ilja M, Mook-Kanamori, Dennis, van der Most, Peter J, Oldmeadow, Christopher, Qian, Yong, Raitakari, Olli, Rawal, Rajesh, Realo, Anu, Rueedi, Rico, Schmidt, Börge, Smith, Albert V, Stergiakouli, Evie, Tanaka, Toshiko, Taylor, Kent, Thorleifsson, Gudmar, Wedenoja, Juho, Wellmann, Juergen, Westra, Harm-Jan, Willems, Sara M, Zhao, Wei, Amin, Najaf, Bakshi, Andrew, Bergmann, Sven, Bjornsdottir, Gyda, Boyle, Patricia A, Cherney, Samantha, Cox, Simon R, Davies, Gail, Davis, Oliver SP, Ding, Jun, Direk, Nese, Eibich, Peter, Emeny, Rebecca T, Fatemifar, Ghazaleh, Faul, Jessica D, Ferrucci, Luigi, Forstner, Andreas J, Gieger, Christian, Gupta, Richa, Harris, Tamara B, Harris, Juliette M, Holliday, Elizabeth G, Hottenga, Jouke-Jan, De Jager, Philip L, Kaakinen, Marika A, Kajantie, Eero, Karhunen, Ville, Kolcic, Ivana, Kumari, Meena, Launer, Lenore J, Franke, Lude, Li-Gao, Ruifang, Liewald, David C, Koini, Marisa, Loukola, Anu, Marques-Vidal, Pedro, Montgomery, Grant W, Mosing, Miriam A, Paternoster, Lavinia, Pattie, Alison, Petrovic, Katja E, Pulkki-Råback, Laura, Quaye, Lydia, Räikkönen, Katri, Rudan, Igor, and Scott, Rodney J
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Biological Sciences ,Genetics ,Mental Health ,Human Genome ,Depression ,Anxiety Disorders ,Bayes Theorem ,Genome-Wide Association Study ,Humans ,Neuroticism ,Phenotype ,Polymorphism ,Single Nucleotide ,LifeLines Cohort Study ,Medical and Health Sciences ,Developmental Biology ,Agricultural biotechnology ,Bioinformatics and computational biology - Abstract
Very few genetic variants have been associated with depression and neuroticism, likely because of limitations on sample size in previous studies. Subjective well-being, a phenotype that is genetically correlated with both of these traits, has not yet been studied with genome-wide data. We conducted genome-wide association studies of three phenotypes: subjective well-being (n = 298,420), depressive symptoms (n = 161,460), and neuroticism (n = 170,911). We identify 3 variants associated with subjective well-being, 2 variants associated with depressive symptoms, and 11 variants associated with neuroticism, including 2 inversion polymorphisms. The two loci associated with depressive symptoms replicate in an independent depression sample. Joint analyses that exploit the high genetic correlations between the phenotypes (|ρ^| ≈ 0.8) strengthen the overall credibility of the findings and allow us to identify additional variants. Across our phenotypes, loci regulating expression in central nervous system and adrenal or pancreas tissues are strongly enriched for association.
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- 2016
28. Genome-wide association study identifies 74 loci associated with educational attainment
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Okbay, Aysu, Beauchamp, Jonathan P, Fontana, Mark Alan, Lee, James J, Pers, Tune H, Rietveld, Cornelius A, Turley, Patrick, Chen, Guo-Bo, Emilsson, Valur, Meddens, S Fleur W, Oskarsson, Sven, Pickrell, Joseph K, Thom, Kevin, Timshel, Pascal, de Vlaming, Ronald, Abdellaoui, Abdel, Ahluwalia, Tarunveer S, Bacelis, Jonas, Baumbach, Clemens, Bjornsdottir, Gyda, Brandsma, Johannes H, Pina Concas, Maria, Derringer, Jaime, Furlotte, Nicholas A, Galesloot, Tessel E, Girotto, Giorgia, Gupta, Richa, Hall, Leanne M, Harris, Sarah E, Hofer, Edith, Horikoshi, Momoko, Huffman, Jennifer E, Kaasik, Kadri, Kalafati, Ioanna P, Karlsson, Robert, Kong, Augustine, Lahti, Jari, Lee, Sven J van der, deLeeuw, Christiaan, Lind, Penelope A, Lindgren, Karl-Oskar, Liu, Tian, Mangino, Massimo, Marten, Jonathan, Mihailov, Evelin, Miller, Michael B, van der Most, Peter J, Oldmeadow, Christopher, Payton, Antony, Pervjakova, Natalia, Peyrot, Wouter J, Qian, Yong, Raitakari, Olli, Rueedi, Rico, Salvi, Erika, Schmidt, Börge, Schraut, Katharina E, Shi, Jianxin, Smith, Albert V, Poot, Raymond A, St Pourcain, Beate, Teumer, Alexander, Thorleifsson, Gudmar, Verweij, Niek, Vuckovic, Dragana, Wellmann, Juergen, Westra, Harm-Jan, Yang, Jingyun, Zhao, Wei, Zhu, Zhihong, Alizadeh, Behrooz Z, Amin, Najaf, Bakshi, Andrew, Baumeister, Sebastian E, Biino, Ginevra, Bønnelykke, Klaus, Boyle, Patricia A, Campbell, Harry, Cappuccio, Francesco P, Davies, Gail, De Neve, Jan-Emmanuel, Deloukas, Panos, Demuth, Ilja, Ding, Jun, Eibich, Peter, Eisele, Lewin, Eklund, Niina, Evans, David M, Faul, Jessica D, Feitosa, Mary F, Forstner, Andreas J, Gandin, Ilaria, Gunnarsson, Bjarni, Halldórsson, Bjarni V, Harris, Tamara B, Heath, Andrew C, Hocking, Lynne J, Holliday, Elizabeth G, Homuth, Georg, and Horan, Michael A
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Biological Sciences ,Genetics ,Epidemiology ,Health Sciences ,Statistics ,Mathematical Sciences ,Human Genome ,Clinical Research ,Alzheimer Disease ,Bipolar Disorder ,Brain ,Cognition ,Computational Biology ,Educational Status ,Fetus ,Gene Expression Regulation ,Gene-Environment Interaction ,Genome-Wide Association Study ,Humans ,Molecular Sequence Annotation ,Polymorphism ,Single Nucleotide ,Schizophrenia ,United Kingdom ,LifeLines Cohort Study ,General Science & Technology - Abstract
Educational attainment is strongly influenced by social and other environmental factors, but genetic factors are estimated to account for at least 20% of the variation across individuals. Here we report the results of a genome-wide association study (GWAS) for educational attainment that extends our earlier discovery sample of 101,069 individuals to 293,723 individuals, and a replication study in an independent sample of 111,349 individuals from the UK Biobank. We identify 74 genome-wide significant loci associated with the number of years of schooling completed. Single-nucleotide polymorphisms associated with educational attainment are disproportionately found in genomic regions regulating gene expression in the fetal brain. Candidate genes are preferentially expressed in neural tissue, especially during the prenatal period, and enriched for biological pathways involved in neural development. Our findings demonstrate that, even for a behavioural phenotype that is mostly environmentally determined, a well-powered GWAS identifies replicable associated genetic variants that suggest biologically relevant pathways. Because educational attainment is measured in large numbers of individuals, it will continue to be useful as a proxy phenotype in efforts to characterize the genetic influences of related phenotypes, including cognition and neuropsychiatric diseases.
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- 2016
29. Cohort profile: Genetic data in the German Socio-Economic Panel Innovation Sample (SOEP-G)
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Koellinger, Philipp D., primary, Okbay, Aysu, additional, Kweon, Hyeokmoon, additional, Schweinert, Annemarie, additional, Linnér, Richard Karlsson, additional, Goebel, Jan, additional, Richte, David, additional, Reiber, Lisa, additional, Zweck, Bettina Maria, additional, Belsky, Daniel W., additional, Biroli, Pietro, additional, Mata, Rui, additional, Tucker-Drob, Elliot M., additional, Harden, K. Paige, additional, Wagner, Gert, additional, and Hertwig, Ralph, additional
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- 2023
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30. G-ROP criteria for predicting retinopathy of prematurity among neonates with different birth weight percentiles
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Okbay Gunes, Asli, Topcuoglu, Sevilay, Celik, Gokhan, Kizilay, Osman, Akyurekli, Muhammed Ali Recai, Karadag, Nilgun, Ozalkaya, Elif, and Karatekin, Guner
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- 2022
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31. Comparative Outcomes of Levetiracetam and Phenobarbital Usage in the Treatment of Neonatal Seizures: A Retrospective Analysis.
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Toptan, Handan Hakyemez, Karadag, Nazmiye Nilgun, Topcuoglu, Sevilay, Ozalkaya, Elif, Dincer, Emre, Cakir, Hakan, Gunes, Asli Okbay, and Karatekin, Guner
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HETEROCYCLIC compounds ,PATIENT safety ,DRUG side effects ,INFANT mortality ,MEDICAL quality control ,T-test (Statistics) ,ACADEMIC medical centers ,PHENOBARBITAL ,ELECTROENCEPHALOGRAPHY ,RETROSPECTIVE studies ,AMIDES ,DISCHARGE planning ,DISEASE remission ,MANN Whitney U Test ,CHI-squared test ,DESCRIPTIVE statistics ,SYMPTOMS ,MULTIVARIATE analysis ,PEDIATRICS ,SEIZURES (Medicine) ,DRUG efficacy ,COMPARATIVE studies ,DATA analysis software ,DISEASE incidence ,EVALUATION ,CHILDREN - Abstract
Objectives and Aim: The primary aim of this study was to conduct a comparative analysis of the safety and efficacy of levetiracetam (LEV) and phenobarbital (PB) as first-line treatments for neonatal seizure management. This study was designed to measure and compare the incidence of adverse effects and to determine the discharge and mortality rates associated with the use of these antiseizure medications (ASMs). Through this comparison, this research sought to provide insights to optimise care for neonates experiencing seizures. Materials and Methods: This retrospective cohort study evaluated 104 neonates treated for seizures at Zeynep Kamil Hospital from 2015 to 2020 after excluding those on non-PB/LEV antiseizure medications. Seizures were characterised using electroencephalogram (EEG) and categorised according to aetiology and frequency. Treatment efficacy was gauged by seizure cessation, as confirmed using EEG. Adverse effects and demographic data were recorded. Statistical analyses were conducted using SPSS, employing the Shapiro–Wilk, independent t-test, Mann–Whitney U test, and chi-square test, with a significance threshold of p < 0.05. Results: Overall, 104 neonates treated with first-line ASM were evaluated for efficacy; PB was administered in 68.26% of the cases, while LEV was utilised in 31.74%. The total complete response rate was 40.38%, with no significant difference between the PB and LEV groups (p = 0.309). The incidence rate ratios (IRRs) demonstrated that seizure frequency profoundly influenced treatment effectiveness, with IRRs of 2.09 for rare seizures, 3.25 for frequent seizures, and 4.01 for status epilepticus, indicating a higher treatment response rate with increasing seizure frequency. For second-line treatment, among a subset of 62 patients, PB had a slight, non-significant advantage over LEV, with an odds ratio of 1.09, suggesting a marginally better response to LEV. Adverse events were significantly more frequent in the PB group, affecting 19 of 67 neonates (28.36%), compared to only 2 of 71 neonates (2.82%) in the LEV group (p < 0.001). No significant difference was observed in the discharge rates between the two groups (PB, 67.61%; LEV, 75.76%; p = 0.674). Interestingly, the mortality rate was significantly higher in the LEV group (45.45%) than that in the PB group (22.54%; p = 0.045). Conclusion: This study underscores LEV's superior safety profile over PB in neonatal seizure management, evidenced by a significantly lower rate of adverse events. PB seems to be more effective in the second-line treatment of neonatal seizures. Despite the lack of significant differences in the discharge rates, the higher mortality rate associated with LEV warrants further investigation. These findings advocate the cautious selection of antiepileptic drugs in neonatal care, with a preference for LEV based on its safety profile. [ABSTRACT FROM AUTHOR]
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- 2024
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32. Self-control is associated with health-relevant disparities in buccal DNA-methylation measures of biological aging in older adults
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Willems, Y.E., primary, deSteiguer, A., additional, Tanksley, P.T., additional, Vinnik, L., additional, Främke, D., additional, Okbay, A., additional, Richter, D., additional, Wagner, G. G., additional, Hertwig, R., additional, Koellinger, P., additional, Tucker-Drob, E.M., additional, Harden, K. P., additional, and Raffington, L., additional
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- 2023
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33. Anxiety and Depression of Neonatal Intensive Care Unit Mothers During the COVID-19 Pandemic
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Aslı OKBAY GÜNEŞ and Neslihan ATLI
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Automotive Engineering ,Anksiyete ,COVID-19 pandemisi ,depresyon ,maternal ,yenidoğan yoğun bakım ünitesi ,Medicine ,Anxiety ,COVID-19 pandemic ,depression ,neonatal intensive care unit ,Tıp - Abstract
Amaç: Pandemi döneminde COVID-19 dışında herhangi bir nedenle bebeği yenidoğan yoğun bakım ünitesine (YYBB) yatırılan annelerde kaygı ve depresyon prevalansını ve YYBB'de kalma süresinin annelerin kaygı ve depresyonuna etkisini belirlemek.Materyal ve metod: YYBB anneleri bebeklerinin hastanede yatış sürelerine göre üç gruba ayrıldı. Bebeklerin hastanede yatış süresi birinci grup annelerde (G1) < 7 gün, ikinci grupta (G2) ≥ 7- 40 idi ve bu da klinik kaygı düzeylerini gösteriyordu. Annelerin 73'ünün (%48.7) EPDS puanı >12 idi. Grup 3’teki annelerin STAI-Durumluk puanları G2'deki annelerden daha yüksekti (p=0.029). Depresyon puanları üç grup arasında farklılık göstermedi.Sonuç: Tüm YYBB annelerinin kaygılı olduğu ve yaklaşık yarısının depresif olduğu saptandı. YYBB'de daha uzun süre kalan bebeklerin annelerinde ortalama durumluk kaygı düzeyleri daha yüksekti., Background: To determine the prevalence of anxiety and depression of the mothers whose babies were admitted to neonatal intensive care unit (NICU) for any reason other than COVID-19 during the pandemic, and the effect of duration of NICU stay on mothers' anxiety and depression.Materials and Methods: The NICU mothers were divided into three groups according to duration of hospitalization of their babies. The duration of hospitalization of the babies was < 7 days for the first group of the mothers (G1), ≥ 7- 40, indicating clinical levels of anxiety. Seventy three (48.7%) of the mothers had a EPDS score > 12. The STAI-State scores of the mothers in G3 were higher than the mothers in G2 (p=0.029). Depression scores did not differ between the three groups.Conclusions: All the NICU mothers were found to be anxious and nearly half of them were depressive. Mean state anxiety levels were higher in mothers of babies who stayed longer in NICU.
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- 2022
34. Educational attainment polygenic scores are associated with cortical total surface area and regions important for language and memory
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Brittany L. Mitchell, Gabriel Cuéllar-Partida, Katrina L. Grasby, Adrian I. Campos, Lachlan T. Strike, Liang-Dar Hwang, Aysu Okbay, Paul M. Thompson, Sarah E. Medland, Nicholas G. Martin, Margaret J. Wright, and Miguel E. Rentería
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Educational attainment ,Brain structure ,Polygenic scores ,Intelligence ,Broca’s area ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
It is well established that higher cognitive ability is associated with larger brain size. However, individual variation in intelligence exists despite brain size and recent studies have shown that a simple unifactorial view of the neurobiology underpinning cognitive ability is probably unrealistic. Educational attainment (EA) is often used as a proxy for cognitive ability since it is easily measured, resulting in large sample sizes and, consequently, sufficient statistical power to detect small associations. This study investigates the association between three global (total surface area (TSA), intra-cranial volume (ICV) and average cortical thickness) and 34 regional cortical measures with educational attainment using a polygenic scoring (PGS) approach. Analyses were conducted on two independent target samples of young twin adults with neuroimaging data, from Australia (N = 1097) and the USA (N = 723), and found that higher EA-PGS were significantly associated with larger global brain size measures, ICV and TSA (R2 = 0.006 and 0.016 respectively, p
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- 2020
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35. Genome-wide association study results for educational attainment aid in identifying genetic heterogeneity of schizophrenia
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V. Bansal, M. Mitjans, C. A. P. Burik, R. K. Linnér, A. Okbay, C. A. Rietveld, M. Begemann, S. Bonn, S. Ripke, R. de Vlaming, M. G. Nivard, H. Ehrenreich, and P. D. Koellinger
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Science - Abstract
Educational attainment and schizophrenia have a negative phenotypic relationship but show positive genetic correlation. Here, the authors study genetic dependence between the two traits and find that multiple genes have pleiotropic effects on both without a systematic pattern of sign concordance.
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- 2018
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36. Selection against variants in the genome associated with educational attainment
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Kong, Augustine, Frigge, Michael L., Thorleifsson, Gudmar, Stefansson, Hreinn, Young, Alexander I., Zink, Florian, Jonsdottir, Gudrun A., Okbay, Aysu, Sulem, Patrick, Masson, Gisli, Gudbjartsson, Daniel F., Helgason, Agnar, Bjornsdottir, Gyda, Thorsteinsdottir, Unnur, and Stefansson, Kari
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- 2017
37. Genetic variants linked to education predict longevity
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Social Science Genetic Association Consortium, Marioni, Riccardo E., Ritchie, Stuart J., Joshi, Peter K., Hagenaars, Saskia P., Okbay, Aysu, Fischer, Krista, Adams, Mark J., Hill, W. David, Davies, Gail, Nagy, Reka, Amador, Carmen, Läll, Kristi, Metspalu, Andres, Liewald, David C., Campbell, Archie, Wilson, James F., Hayward, Caroline, Esko, Tõnu, Porteous, David J., Gale, Catharine R., and Deary, Ian J.
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- 2016
38. Factors Associated with the Transition Time to Full Enteral Feeding in Newborns with Hypoxic Ischemic Encephalopathy
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Asli Okbay Gunes, Nilgun Karadag, Sevilay Topcuoglu, Elif Ozalkaya, Handan Hakyemez Toptan, Emre Dincer, Hakan Cakir, and Guner Karatekin
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General Medicine - Abstract
Background: We aimed to assess the factors associated with the transition time to full enteral feeding (FEF) in newborns with hypoxic ischemic encephalopathy (HIE) undergoing therapeutic hypothermia. Methods: We obtained data retrospectively from medical records of the neonates diagnosed with HIE and treated by therapeutic hypothermia to evaluate the factors associated with transition time to FEF. Results: Sixty-one neonates were included in the study. The median gestational age (GA) and birth weight were 39 (37–40) weeks and 3245 (2715–3575) grams, respectively. APGAR scores at the first and fifth minutes were 3 (1–5) and 6 (4–7), respectively. Fifty-seven (93.4%) of the newborns were diagnosed as having moderate HIE, and 4 (6.6%) of them had severe HIE. Transition time to FEF was found to be negatively correlated with gestational week (r, P: -0.280, 0.029) and birth weight (r, P: -0.315, 0.013); and positively correlated with lactate (r, P: 0.295, 0.044), BUN (r, P: 0.285, 0.026) and creatinine levels (r, P: 0.345, 0.007); duration of invasive (r, P: 0.565, 0.0001) and non-invasive mechanical ventilation (r, P: 0.261, 0.042), use of antibiotics (r, P: 0.556, 0.0001) and inotropic agents (r, P: 0.524, 0.0001) and hospitalization (r, P: 0.654, 0.0001). Conclusion: Clinicians should be more careful while starting to feed babies undergoing therapeutic hypothermia with higher lactate levels and impaired renal functions, and should be encouraged to feed clinically stable neonates with HIE as soon as possible, as the transition time to FEF could be related with better clinical outcomes.
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- 2022
39. The Effect of Breastfeeding Self-Efficacy on Infants’ Weights and Breastfeeding Outcomes.
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Güneş, Aslı Okbay, Karadağ, Nilgün, and Karatekin, Güner
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MANN Whitney U Test , *SELF-efficacy , *WEIGHT gain , *PEARSON correlation (Statistics) , *BREASTFEEDING , *DESCRIPTIVE statistics , *DATA analysis software , *SUCCESS , *LONGITUDINAL method - Abstract
Objective: The aim of this study was to investigate the effects of breastfeeding self-efficacy (BSE) and breastfeeding success (BFS) on infants’ weight gain rates and breastfeeding outcomes. Materials and Methods: Mothers were evaluated within the postpartum 72 hours with “Breastfeeding Self-Efficacy Scale—Short Form (BSES-SF)” and “LATCH Scale.” After 6 months, the mothers were called to learn the exclusive breastfeeding (EB) duration and the weight of the infants. Results: Two hundred mother–infant couples were enrolled, 176 (88%) of them could be reached in the sixth month. The BSES-SF scores were positively correlated with LATCH scores (P = .0001). The EB rate in the sixth month was positively correlated with BFS but not correlated with BSE (r, P = .218, .004; .79, .297, respectively). The percentage of weight gain and the rate of weight percentile change of babies according to birth weight at the sixth month of age were negatively correlated with BSE (r = −0.226, −0.148, P = .003, .049, respectively) but not correlated with BFS. Conclusion: Higher BFS was associated with increased duration of EB in the first 6 months of life, and higher BSE was related to lower increase in the percentage of weight gain and a lower rate of weight percentile change of babies at 6 months of age. [ABSTRACT FROM AUTHOR]
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- 2023
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40. The efficacy of oral motor interventions on feeding outcomes in newborns with hypoxic-ischemic encephalopathy who received therapeutic hypothermia.
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Bozkaya, Aydın, Güneş, Aslı Okbay, Çiftçi, Hilal Berber, and Davutoğlu, Salih
- Abstract
Background. Feeding difficulties continue to be a serious problem in newborns with hypoxic-ischemic encephalopathy (HIE) undergoing therapeutic hypothermia (TH). The aim of this study was to investigate the efficacy of oral motor interventions (OMI) on feeding outcomes in neonates with HIE/TH. Methods. This was a prospective randomised control study conducted between January 2022 and September 2022. Premature Infant Oral Motor Intervention (PIOMI) was used as OMI. Newborns with HIE/TH, who underwent PIOMI, constituted the study group, and newborns, who did not receive any feeding exercise, constituted the control group. Transition time to full oral feeding (FOF) was determined as the time between initiation of tube feeding and full oral breastfeeding or bottle feeding. The day per oral (PO) feeding was started was specified as PO first, the day the infants could take half of the volume of the feedings by mouth was PO half, and the day the infants could take all the feedings by mouth was PO full. Results. There were 50 neonates in each group. Time to FOF was significantly shorter in the study group than in the control group in all stages of HIE/TH (P= 0.008 for stage 1, and <0.001 for stage 2 and 3 HIE). However, times to PO first, PO half, PO full and discharge were shorter in the study group than in the control group only in the neonates with stage 3 HIE (P= 0.003, 0.014, 0.013, 0.042, respectively). Conclusions. The PIOMI, which could be named as "HIE-OMI" in our study, is an effective intervention in shortening the transition time to FOF in neonates with all stages of HIE undergoing TH. In addition, "HIEOMI" shortens the length of hospital stay, and improves feeding outcomes in neonates with severe HIE/TH. [ABSTRACT FROM AUTHOR]
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- 2023
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41. Mendelian imputation of parental genotypes improves estimates of direct genetic effects
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Alexander I. Young, Seyed Moeen Nehzati, Stefania Benonisdottir, Aysu Okbay, Hariharan Jayashankar, Chanwook Lee, David Cesarini, Daniel J. Benjamin, Patrick Turley, Augustine Kong, Economics, Tinbergen Institute, and Amsterdam Neuroscience - Complex Trait Genetics
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Parents ,Genotype ,Human Genome ,Single Nucleotide ,Biological Sciences ,Polymorphism, Single Nucleotide ,Medical and Health Sciences ,Genetics ,Humans ,2.1 Biological and endogenous factors ,Generic health relevance ,Polymorphism ,Aetiology ,Software ,Genome-Wide Association Study ,Developmental Biology - Abstract
Effects estimated by genome-wide association studies (GWASs) include effects of alleles in an individual on that individual (direct genetic effects), indirect genetic effects (for example, effects of alleles in parents on offspring through the environment) and bias from confounding. Within-family genetic variation is random, enabling unbiased estimation of direct genetic effects when parents are genotyped. However, parental genotypes are often missing. We introduce a method that imputes missing parental genotypes and estimates direct genetic effects. Our method, implemented in the software package snipar (single-nucleotide imputation of parents), gives more precise estimates of direct genetic effects than existing approaches. Using 39,614 individuals from the UK Biobank with at least one genotyped sibling/parent, we estimate the correlation between direct genetic effects and effects from standard GWASs for nine phenotypes, including educational attainment (r = 0.739, standard error (s.e.) = 0.086) and cognitive ability (r = 0.490, s.e. = 0.086). Our results demonstrate substantial confounding bias in standard GWASs for some phenotypes.
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- 2022
42. Disentangling polygenic associations between attention-deficit/hyperactivity disorder, educational attainment, literacy and language
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Verhoef, Ellen, Demontis, Ditte, Burgess, Stephen, Shapland, Chin Yang, Dale, Philip S., Okbay, Aysu, Neale, Benjamin M., Faraone, Stephen V., iPSYCH-Broad-PGC ADHD Consortium, Stergiakouli, Evie, Davey Smith, George, Fisher, Simon E., Børglum, Anders D., and St Pourcain, Beate
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- 2019
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43. Efficacy and safety of endotracheal instillation of iloprost for persistent pulmonary hypertension of the newborn
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Asli Okbay Gunes, Murat Ciftel, Mehmet Emcet Timur, Ceren Dedebali, and Betul Zehra Pirdal
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Pediatrics, Perinatology and Child Health ,General Medicine ,Cardiology and Cardiovascular Medicine - Abstract
Objective:To determine the efficacy and safety of endotracheal instillation of iloprost as a rescue therapy for persistent pulmonary hypertension of the newborn.Methods:Neonates diagnosed with persistent pulmonary hypertension who were unresponsive to standard treatment protocol applied for persistent pulmonary hypertension in our unit, and who were being followed up with mechanical ventilation, were included in the study. Iloprost was instilled endotracheally as a rescue treatment. Systolic pulmonary artery pressure, oxygen saturation index, mean airway pressure, fraction of inspired oxygen, preductal and postductal venous oxygen saturation, heart rate, and blood pressure were recorded before and after 30 minutes of endotracheal iloprost instillation. Adverse events after endotracheal iloprost were recorded.Results:Twenty neonates were included. The median gestational age and birth weight were found to be 37 (30.5-38) weeks and 2975 (2125-3437.5) grams, respectively. When compared to the period before endotracheal iloprost instillation, systolic pulmonary artery pressure, oxygen saturation index, mean airway pressure, and fraction of inspired oxygen values significantly decreased (p < 0.001, p < 0.001, p = 0.021, p = 0.001, respectively), whereas preductal and postductal oxygen saturation values significantly increased 30 minutes after the endotracheal iloprost instillation (p = 0.002, p < 0.001, respectively). There were no significant differences in heart rate and blood pressure values before and after the iloprost administration. No adverse events were observed.Conclusion:Endotracheal instillation of iloprost was found to be an effective and safe therapy for persistent pulmonary hypertension unresponsive to conventional treatment.
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- 2022
44. Ciddi ve Orta Derece Preterm Bebeklerde Kordon Kanı Nötrofil Düzeylerinin Erken Sepsis ile İlişkisi
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OKBAY GÜNEŞ, Asli, TOPÇUOĞLU, Sevilay, KARADAĞ, Nilgün, ÖZALKAYA, Elif, and KARATEKİN, Güner
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Pediatri ,Erken sepsis ,kordon kanı ,nötrofil sayısı ,prematürite ,Pediatrics ,Early onset sepsis ,cord blood ,neutrophil count ,prematurity - Abstract
AmaçCiddi ve orta derece preterm bebeklerde kordon kanı nötrofil değerlerinin erken yenidoğan sepsisi (EYS) ve EYS risk etmenleri ile ilişkisinin belirlenmesi amaçlandı. Çalışma planı Geriye dönük çalışmamızda ünitemizde en az yedi gün yatırılan, 28-34 gebelik haftaları arasında doğan olgular değerlendirildi. Göbek kordonundan ya da yaşamın ilk iki saatinde venöz alınan kan sayımları ile kan kültürü sonuçları, CRP değerleri, EYS için risk etmenleri ve klinik özellikler kaydedildi. BulgularHastaların (n=100) ortalama doğum ağırlıkları ve gebelik haftaları sırasıyla 1617±408 gram ve 32,19±1,6 hafta idi. Olguların 33’ünün kordon, 67’sinin doğum sonrası ilk iki saat içinde alınan venöz nötrofil sayıları değerlendirildi. Kordon kanı ve venöz nötrofil değerleri arasında fark saptanmadı (p=0,936). Erken yenidoğan sepsisi ve EYS risk etmeni olanlarla olmayanlar arasında nötrofil değerleri açısından fark saptanmadı (sırasıyla p=0,076, 0,95). Nötrofil düzeyleri gebelik haftası ve doğum ağırlığı ile aynı, CRP değerleri ile zıt yönlü ilişikili saptandı (sırasıyla r, p= 0,282, 0,004; 0,437, 0,0001; -0,209, 0,037). SonuçKordon kanı ve venöz kan nötrofil düzeyleri ile EYS ve EYS risk etmenleri arasında ilişki saptanmadı. Bulgularımız preterm bebeklerde nötrofil değerlerinin gebelik haftası ve doğum ağırlığı göz önüne alınarak değerlendirilmesi gerektiğini düşündürmektedir., IntroductionIt was aimed to determine the relationship between cord blood neutrophil values and early onset neonatal sepsis (ENS) and ENS risk factors in very and moderate preterm infants.MethodsIn our retrospective study, the cases who were born between 28-34 weeks of gestation and hospitalized for at least seven days were evaluated. Blood counts obtained from umbilical cord or in the first two hours of life, blood culture results, CRP values, risk factors for ENS, and clinical features were recorded.ResultsThe mean birth weight and gestational age of patients (n=100) were 1617±408 grams, and 32.19±1.6 weeks, respectively. In the 33 of the cases the cord blood, and in the 67 of the cases venous neutrophil counts taken within the first two hours after delivery were evaluated. There was no difference between cord and venous blood neutrophil values (p= 0.936). There was no difference in terms of neutrophil values between those with/without ENS and with/without ENS risk factors (p = 0.076, 0.95, respectively). Neutrophil levels were positively correlated with gestational week and birth weight, and negatively correlated with CRP values (r, p = 0.282, 0.004; 0.437, 0.0001; -0.209, 0.037, respectively).ConclusionNo relationship was found between cord blood/ venous blood neutrophil levels and ENS/ ENS risk factors. Our findings suggest that neutrophil values should be evaluated by considering gestational age and birth weight in preterm infants.
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- 2022
45. Anxiety and Depression of Neonatal Intensive Care Unit Mothers During the COVID-19 Pandemic
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OKBAY GÜNEŞ, Aslı, primary and ATLI, Neslihan, additional
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- 2022
- Full Text
- View/download PDF
46. Genome-wide association meta-analysis of 78,308 individuals identifies new loci and genes influencing human intelligence
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Sniekers, Suzanne, Stringer, Sven, Watanabe, Kyoko, Jansen, Philip R, Coleman, Jonathan R I, Krapohl, Eva, Taskesen, Erdogan, Hammerschlag, Anke R, Okbay, Aysu, Zabaneh, Delilah, Amin, Najaf, Breen, Gerome, Cesarini, David, Chabris, Christopher F, Iacono, William G, Ikram, M Arfan, Johannesson, Magnus, Koellinger, Philipp, Lee, James J, Magnusson, Patrik K E, McGue, Matt, Miller, Mike B, Ollier, William E R, Payton, Antony, Pendleton, Neil, Plomin, Robert, Rietveld, Cornelius A, Tiemeier, Henning, van Duijn, Cornelia M, and Posthuma, Danielle
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- 2017
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47. The Usability of Platelet Mass Index Thresholds to Assess the Repeated Platelet Transfusion Requirements in Neonates
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Asli Okbay Gunes, Suleyman Geter, and Mehmet Emin Avlanmis
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Hematology - Published
- 2022
48. Brain-wide multimodal associations of polygenic scores (BIG BEAR - PGS project)
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Koellinger, Philipp, Nooshin, Nave, Gideon, Okbay, Aysu, Dagher, Alain, and Bzdok, Danilo
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UK Biobank ,Neuroscience and Neurobiology ,Life Sciences ,GWAS ,Genetics and Genomics ,Neuroimaging ,Brain anatomy ,Polygenic scores - Abstract
Numerous large-scale genome-wide association studies (GWAS) have recently been conducted on traits that are of interest to social scientists, spanning various measures of personality, cognition, reproduction, well-being, and health-related factors. These GWAS have identified thousands of genome-wide significant loci and enabled the creation of polygenic scores that begin to capture observed differences between individuals in a robust, replicable manner. Not surprisingly, bioinformatic annotations of these GWAS results all point to cell types and biological processes in the brain. Yet, more precise bioinformatic annotations (for example to identify specific brain regions or systems) are limited by the small sample sizes of brain tissue datasets. Furthermore, the available brain tissue samples were extracted either from non-human species or deceased humans and they provide only a limited resolution regarding the relevant features of brain anatomy and function. Here, we aim to provide new insights into which aspects of brain anatomy and function these GWAS results tap into, either as precursors or consequences of human behavior. Specifically, we plan to empirically test the relationship between a set of polygenic risk scores (PRS) derived from large-scale GWAS of selected behavioral traits to identify related differences in brain morphology and function obtained from multimodal MRI scans.
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- 2022
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49. Genome-wide association study on income
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Koellinger, Philipp, Kweon, Hyeokmoon, Burik, Casper, DiPrete, Thomas, Linnér, Richard, and Okbay, Aysu
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The purpose of this study is to generate a set of publicly available genome-wide association study (GWAS) results on income that will provide researchers from various disciplines with new, better ways to study the causes and consequences of inequality and social mobility – two matters that are of fundamental importance for science and policy
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- 2022
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50. Genetics and causality in the educational attainment-coronary artery disease relationship
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Aysu Okbay, Economics, Tinbergen Institute, and Amsterdam Neuroscience - Complex Trait Genetics
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Gerontology ,Coronary artery disease ,SDG 3 - Good Health and Well-being ,business.industry ,MEDLINE ,Medicine ,Cardiology and Cardiovascular Medicine ,business ,medicine.disease ,Causality ,Educational attainment - Abstract
This editorial refers to ‘Genetically modulated educational attainment and coronary disease risk’, by L. Zeng et al., doi:10.1093/eurheartj/ehz328.
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- 2022
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