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Factors Associated with Post-rewarming Procalcitonin Levels in Newborns with Hypoxic Ischemic Encephalopathy.
- Source :
-
Turkish Archives of Pediatrics . Jul2024, Vol. 59 Issue 4, p404-409. 6p. - Publication Year :
- 2024
-
Abstract
- Objective: To determine the factors associated with the procalcitonin levels in newborns with hypoxic-ischemic encephalopathy (HIE) who received therapeutic hypothermia (TH). Materials and Methods: The neonates, who had moderate/severe HIE and were treated with TH, were included. The neonates were arranged into 2 groups by procalcitonin (PCT) level after rewarming was completed. The neonates who had a procalcitonin level of < 2.5 ng/ml constituted Group 1 and the ones who had a procalcitonin level of ≥ 2.5 ng/ml constituted Group 2. Univariate and multivariate logistic regression was used to assess the factors related with PCT level. Results: The first group included 123 (87.9%) neonates and the second group included 17 (12.1%) neonates. The median gestational age was 38 (36-39) weeks and the mean birth weight was 3081.7 ± 552.8 grams. In group 2, the rates for severe HIE, cesarean section, antibiotic switch, convulsion, inotrope use and mortality were higher, and duration of hospitalization was longer, whereas Apgar scores were lower (P < .05). The risk of a high procalcitonin level was found to be 6-fold (95% CI 1.9-19.1) higher in severe HIE and 5.2-fold higher (95% CI 1.7-16) in cesarean delivery. Conclusion: In neonates with HIE/TH, high post-rewarming procalcitonin levels were related with severe HIE and cesarean delivery. Some other clinical and laboratory findings, which may reflect worse clinical status, were also associated with high procalcitonin levels. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CROSS-sectional method
*CEREBRAL anoxia-ischemia
*ACADEMIC medical centers
*T-test (Statistics)
*THERMOTHERAPY
*LOGISTIC regression analysis
*ELECTROENCEPHALOGRAPHY
*NEONATAL intensive care units
*CALCITONIN
*TREATMENT effectiveness
*DESCRIPTIVE statistics
*RETROSPECTIVE studies
*NEONATAL intensive care
*MANN Whitney U Test
*GESTATIONAL age
*COMPARATIVE studies
*DATA analysis software
*CHILDREN
Subjects
Details
- Language :
- English
- ISSN :
- 27576256
- Volume :
- 59
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Turkish Archives of Pediatrics
- Publication Type :
- Academic Journal
- Accession number :
- 178324382
- Full Text :
- https://doi.org/10.5152/TurkArchPediatr.2024.24089