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14. Low levels of urinary epidermal growth factor predict chronic kidney disease progression in children

Author

Mir, Sevgi, Hohbach-Hohenfellner, Katharina, Jeck, Nickola, Smith, Michelle, Klaus, Guenter, Ardissino, Gianluigi, Testa, Sara, Montini, Giovanni, Charbit, Marina, Niaudet, Patrick, Afonso, Alberto Caldas, Fernandes-Teixeira, Ana, Peruzzi, Licia, Arbeiter, Klaus, Jankauskiene, Augustina, Grenda, Ryszard, Litwin, Mieczyslaw, Neuhaus, Thomas J., Fang, Zhiyin, Dusek, Jiri, Matteucci, Chiara, Azukaitis, Karolis, Picca, Stefano, Ju, Wenjun, Thurn-Valsassina, Daniela, Kirchner, Marietta, Wigger, Marianne, Berg, Ulla B., Celsi, Giovanni, Fischbach, Michel, Terzic, Joelle, Vidal, Enrico, TABEL, YILMAZ, Gimpel, Charlotte, ERTAN, PELİN, Yavascan, Onder, Melk, Anette, Querfeld, Uwe, Wuehl, Elke, Kretzler, Matthias, Schaefer, Franz, Rosales, Alejandra, Zaloszyc, Ariane, Gellermann, Jutta, Liebau, Max, Weber, Lutz, Muschiol, Evelin, Buescher, Rainer, Oh, Jun, Thurn-Valassina, Daniela, Haffner, Dieter, John, Ulrike, Wygoda, Simone, Jeck, Nikola, Murer, Luisa, Drozdz, Dorota, Coppo, Rosanna, Lugani, Francesca, Zurowska, Aleksandra, Zaniew, Marcin, Nimierska, Anna, Teixeira, Ana, Peco-Antic, Amira, Laube, Guido, Dali, Cocuk Nefrolojisi Bilim, Anarat, Ali, Bayazit, Aysun, DÜZOVA, ALİ, BİLGİNER, YELDA, ÇALIŞKAN, Salim, CANPOLAT, Nur, Civilibal, Mahmut, Shroff, Rukshana, Soezeri, Betul, Kranz, Brigitta, Mencarelli, Francesca, Dorn, Brigitte, Nair, Viji, Yalcinkaya, Fatos, Baskin, Esra, Cakar, Nilgun, Soylemezoglu, Oguz, Emre, Sevinc, Candan, Cengiz, Kiyak, Aysel, Ozcelik, Gul, Alpay, Harika, Rachin, Bruno, Szczepanska, Maria, Erdogan, Hakan, DÖNMEZ, OSMAN, Balat, Ayse, Aksu, Nejat, Tabel, Yilmaz, Ertan, Pelin, Yilmaz, Ebru, Bakkaloglu, Aysin, ÖZALTIN, FATİH, Sallay, Peter, Bonzel, Klaus-Eugen, Wingen, Anna-Margrete, Urowska, Aleksandra Z., Balasz, Irena, Trivelli, Antonella, Perfumo, Francesco, Mueller-Wiefel, Dirk-Erhard, Moeller, Kerstin, Offner, Gisela, Enke, Barbara, Hadtstein, Charlotte, Mehls, Otto, Fydryk, Janusz, Urasinski, Tomasz, KARABAY BAYAZIT, AYSUN, Niemirska, Anna, KAPLAN BULUT, İPEK, Paripovic, Dusan, Harambat, Jerome, ÇAKAR, NİLGÜN, ALPAY, HARİKA, Çukurova Üniversitesi, Bursa Uludağ Üniversitesi/Tıp Fakültesi/Dahili Tıp Bilimleri/Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı., Dönmez, Osman, AAA-8778-2021, Clinic of Pediatrics, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania, Department of Internal Medicine/Nephrology, University of Michigan, Ann Arbor, MI, United States, Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, United States, Institute of Medical Biometry and Informatics, University of Heidelberg, Heidelberg, Germany, Department of Kidney, Liver and Metabolic Diseases, Hannover Medical School, Hannover, Germany, Department of Pediatric Nephrology, Cukurova University, Adana, Turkey, Department of Nephrology, Kidney Transplantation and Arterial Hypertension, The Children`s Memorial Health Institute, Warsaw, Poland, Department of Pediatric Nephrology, Istanbul University Cerrahpasa Faculty of Medicine, Istanbul, Turkey, Division of Pediatric Nephrology, Department of Pediatrics, Ege University Faculty of Medicine, Izmir, Turkey, Division of Pediatric Nephrology, Department of Pediatrics, School of Medicine, Ankara University, Ankara, Turkey, Department of Pediatric Nephrology, University Children's Hospital, Belgrade, Serbia, Department of Pediatrics, Bordeaux University Hospital, Bordeaux, France, Department of Pediatric Nephrology, Marmara University Faculty of Medicine, Istanbul, Turkey, Division of Nephrology, Dialysis, Transplantation, University of Genoa, G. Gaslini Institute, Genoa, Italy, Pediatric Nephrology Unit, Department of Pediatrics, S.Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy, Department of Pediatric Nephrology, Haseki Educational and Research Hospital, Istanbul, Turkey, Department of Pediatric Nephrology, Bursa Yuksek Ihtisas Teaching and Researching Hospital, Bursa, Turkey, Pediatric Nephrology, Charité Children's Hospital, Berlin, Germany, Pediatric Nephrology, Dialysis and Transplantation Unit, Department of Woman's and Child's Health, University-Hospital of Padova, Padova, Italy, Department of Pediatric Nephrology, Faculty of Medicine, İnönü University, Malatya, Turkey, Department of General Pediatrics, Adolescent Medicine and Neonatology, Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany, Department of Pediatric Nephrology, Celal Bayar University, Manisa, Turkey, Department of Pediatric Nephrology, University of Health Sciences, İzmir Tepecik Training and Research Hospital, İzmir, Turkey, Department of Pediatric Nephrology, Charité University, Berlin, Germany, and Division of Pediatric Nephrology, Center for Pediatrics and Adolescent Medicine, Heidelberg University Hospital, Heidelberg, Germany

Subjects
Male, 0301 basic medicine, Chronic kidney failure, Physiology, Protein function, Medizin, 030232 urology & nephrology, Comorbidity, Urine, urologic and male genital diseases, Gastroenterology, 0302 clinical medicine, Pathology, Urology & nephrology, Estimated glomerular filtration rate, Disease course, pediatric CKD, Child, Priority journal, Kidney, female genital diseases and pregnancy complications, CKD progression, chronic kidney disease, epidermal growth factor, 3. Good health, Risk-factors, Proteinuria, medicine.anatomical_structure, Nephrology, Systolic blood pressure, Glomerulus filtration rate, Biomarker (medicine), Female, Glomerular filtration rate, Cohort analysis, Age factors, Human, medicine.medical_specialty, Adolescent, Urinary system, Excretion, Predictive value, Renal function, Follow-up studies, Major clinical study, Urinalysis, Pathophysiology, Article, Roles, 03 medical and health sciences, Age, Internal medicine, Post-hoc analysis, medicine, Humans, Predictive value of tests, Post hoc analysis, Renal insufficiency, chronic, Prospective study, Disease exacerbation, Egf, Disease progression, Renal replacement therapy, business.industry, Follow up, medicine.disease, Glomerulopathy, Chronic Kidney Failure, Kidney Diseases, Young-adults, Biological marker, 030104 developmental biology, Risk factors, Risk factor, Prediction, business, Prospective studies, Controlled study, Biomarkers, Kidney disease
Abstract

PubMedID: 31005273 Urinary epidermal growth factor (uEGF) has recently been identified as a promising biomarker of chronic kidney disease (CKD) progression in adults with glomerular disease. Low levels of uEGF predict CKD progression and appear to reflect the extent of tubulointerstitial damage. We investigated the relevance of uEGF in pediatric CKD. We performed a post hoc analysis of the Cardiovascular Comorbidity in Children with CKD (4C) study, which prospectively follows children aged 6–17 years with baseline estimated glomerular filtration rate (eGFR) of 10–60 ml/min/1.73 m2. uEGF levels were measured in archived urine collected within 6 months of enrollment. Congenital abnormalities of the kidney and urinary tract were the most common cause of CKD, with glomerular diseases accounting for

Published
2019

23. Low levels of urinary epidermal growth factor predict chronic kidney disease progression in children

Author

Azukaitis, Karolis, Ju, Wenjun, Kirchner, Marietta, Nair, Viji, Smith, Michelle, Fang, Zhiyin, Thurn-Valsassina, Daniela, Bayazit, Aysun, Niemirska, Anna, Canpolat, Nur, Bulut, Ipek Kaplan, Yalcinkaya, Fatos, Paripovic, Dusan, Harambat, Jerome, Cakar, Nilgun, Alpay, Harika, Lugani, Francesca, Mencarelli, Francesca, Civilibal, Mahmut, Erdogan, Hakan, Gellermann, Jutta, Vidal, Enrico, Tabel, Yilmaz, Gimpel, Charlotte, Ertan, Pelin, Yavascan, Onder, Melk, Anette, Querfeld, Uwe, Wuehl, Elke, Kretzler, Matthias, Schaefer, Franz, Arbeiter, Klaus, Rosales, Alejandra, Dusek, Jiri, Zaloszyc, Ariane, Liebau, Max, Weber, Lutz, Muschiol, Evelin, Buescher, Rainer, Oh, Jun, Thurn-Valassina, Daniela, Haffner, Dieter, John, Ulrike, Wygoda, Simone, Jeck, Nikola, Wigger, Marianne, Testa, Sara, Murer, Luisa, Matteucci, Chiara, Jankauskiene, Augustina, Drozdz, Dorota, Zurowska, Aleksandra, Zaniew, Marcin, Litwin, Mieczyslaw, Nimierska, Anna, Teixeira, Ana, Peco-Antic, Amira, Laube, Guido, Dali, Cocuk Nefrolojisi Bilim, Anarat, Ali, Duzova, Ali, Bilginer, Yelda, Caliskan, Salim, Mir, Sevgi, Soezeri, Betul, Kranz, Brigitta, Dorn, Brigitte, Baskin, Esra, Soylemezoglu, Oguz, Emre, Sevinc, Candan, Cengiz, Kiyak, Aysel, Ozcelik, Gul, Shroff, Rukshana, Rachin, Bruno, Szczepanska, Maria, Donmez, Osman, Balat, Ayse, Aksu, Nejat, Yilmaz, Ebru, Bakkaloglu, Aysin, Ozaltin, Fatih, Sallay, Peter, Bonzel, Klaus-Eugen, Wingen, Anna-Margrete, Urowska, Aleksandra Z., Balasz, Irena, Trivelli, Antonella, Perfumo, Francesco, Mueller-Wiefel, Dirk-Erhard, Moeller, Kerstin, Offner, Gisela, Enke, Barbara, Hadtstein, Charlotte, Mehls, Otto, Hohbach-Hohenfellner, Katharina, Jeck, Nickola, Klaus, Guenter, Ardissino, Gianluigi, Montini, Giovanni, Charbit, Marina, Niaudet, Patrick, Afonso, Alberto Caldas, Fernandes-Teixeira, Ana, Picca, Stefano, Berg, Ulla B., Celsi, Giovanni, Fischbach, Michel, Terzic, Joelle, Fydryk, Janusz, Urasinski, Tomasz, Coppo, Rosanna, Peruzzi, Licia, Grenda, Ryszard, Neuhaus, Thomas J., Azukaitis, Karolis, Ju, Wenjun, Kirchner, Marietta, Nair, Viji, Smith, Michelle, Fang, Zhiyin, Thurn-Valsassina, Daniela, Bayazit, Aysun, Niemirska, Anna, Canpolat, Nur, Bulut, Ipek Kaplan, Yalcinkaya, Fatos, Paripovic, Dusan, Harambat, Jerome, Cakar, Nilgun, Alpay, Harika, Lugani, Francesca, Mencarelli, Francesca, Civilibal, Mahmut, Erdogan, Hakan, Gellermann, Jutta, Vidal, Enrico, Tabel, Yilmaz, Gimpel, Charlotte, Ertan, Pelin, Yavascan, Onder, Melk, Anette, Querfeld, Uwe, Wuehl, Elke, Kretzler, Matthias, Schaefer, Franz, Arbeiter, Klaus, Rosales, Alejandra, Dusek, Jiri, Zaloszyc, Ariane, Liebau, Max, Weber, Lutz, Muschiol, Evelin, Buescher, Rainer, Oh, Jun, Thurn-Valassina, Daniela, Haffner, Dieter, John, Ulrike, Wygoda, Simone, Jeck, Nikola, Wigger, Marianne, Testa, Sara, Murer, Luisa, Matteucci, Chiara, Jankauskiene, Augustina, Drozdz, Dorota, Zurowska, Aleksandra, Zaniew, Marcin, Litwin, Mieczyslaw, Nimierska, Anna, Teixeira, Ana, Peco-Antic, Amira, Laube, Guido, Dali, Cocuk Nefrolojisi Bilim, Anarat, Ali, Duzova, Ali, Bilginer, Yelda, Caliskan, Salim, Mir, Sevgi, Soezeri, Betul, Kranz, Brigitta, Dorn, Brigitte, Baskin, Esra, Soylemezoglu, Oguz, Emre, Sevinc, Candan, Cengiz, Kiyak, Aysel, Ozcelik, Gul, Shroff, Rukshana, Rachin, Bruno, Szczepanska, Maria, Donmez, Osman, Balat, Ayse, Aksu, Nejat, Yilmaz, Ebru, Bakkaloglu, Aysin, Ozaltin, Fatih, Sallay, Peter, Bonzel, Klaus-Eugen, Wingen, Anna-Margrete, Urowska, Aleksandra Z., Balasz, Irena, Trivelli, Antonella, Perfumo, Francesco, Mueller-Wiefel, Dirk-Erhard, Moeller, Kerstin, Offner, Gisela, Enke, Barbara, Hadtstein, Charlotte, Mehls, Otto, Hohbach-Hohenfellner, Katharina, Jeck, Nickola, Klaus, Guenter, Ardissino, Gianluigi, Montini, Giovanni, Charbit, Marina, Niaudet, Patrick, Afonso, Alberto Caldas, Fernandes-Teixeira, Ana, Picca, Stefano, Berg, Ulla B., Celsi, Giovanni, Fischbach, Michel, Terzic, Joelle, Fydryk, Janusz, Urasinski, Tomasz, Coppo, Rosanna, Peruzzi, Licia, Grenda, Ryszard, and Neuhaus, Thomas J.

Abstract

Urinary epidermal growth factor (uEGF) has recently been identified as a promising biomarker of chronic kidney disease (CKD) progression in adults with glomerular disease. Low levels of uEGF predict CKD progression and appear to reflect the extent of tubulointerstitial damage. We investigated the relevance of uEGF in pediatric CKD. We performed a post hoc analysis of the Cardiovascular Comorbidity in Children with CKD (4C) study, which prospectively follows children aged 6-17 years with baseline estimated glomerular filtration rate (eGFR) of 10-60 ml/min/1.73 m(2). uEGF levels were measured in archived urine collected within 6 months of enrollment. Congenital abnormalities of the kidney and urinary tract were the most common cause of CKD, with glomerular diseases accounting for <10% of cases. Median eGFR at baseline was 28 ml/min/1.73 m(2), and 288 of 623 participants (46.3%) reached the composite endpoint of CKD progression (50% eGFR loss, eGFR < 10 ml/min/1.73 m(2), or initiation of renal replacement therapy). In a Cox proportional hazards model, higher uEGF/Cr was associated with a decreased risk of CKD progression (HR 0.76; 95% CI 0.69-0.84) independent of age, sex, baseline eGFR, primary kidney disease, proteinuria, and systolic blood pressure. The addition of uEGF/Cr to a model containing these variables resulted in a significant improvement in C-statistics, indicating better prediction of the 1-, 2- and 3-year risk of CKD progression. External validation in a prospective cohort of 222 children with CKD demonstrated comparable results. Thus, uEGF may be a useful biomarker to predict CKD progression in children with CKD.

Published
2019

48. Adult height achieved in children after kidney transplantation

Author

Aschendorff, Carsten, Offner, Gisela, Winkler, Lothar, Schirg, Eckhart, Hoyer, Peter F., and Brodehl, Johannes

Subjects
Chronic renal failure in children -- Complications, Corticosteroids -- Dosage and administration, Kidneys -- Transplantation, Growth disorders -- Causes of, Child development deviations -- Physiological aspects, Family and marriage, Health
Abstract

One of the complications of chronic renal (kidney) failure in children is the inhibition of normal growth and development. Improvements in growth are often seen after kidney transplantation. In addition, the use of cyclosporine, an immunosuppressant agent administered after transplantation to prevent graft rejection, has allowed the reduction of corticosteroid dose (drugs used in the maintenance therapy for these patients), which has led to better growth rates. To further investigate these effects, 20 adolescents between the ages of 10 and 17 years who underwent a kidney transplantation were monitored from 1974 to 1986. The subjects were treated with either cyclosporine and low doses of prednisolone, a corticosteroid drug (nine children), or with azathioprine and high doses of prednisolone (11 children). Bone growth measurements were taken at the time of transplantation, and the normal adult height of each patient was estimated at this time. The bone ages in all the subjects were comparable at transplantation. However, after the transplant operation, the children treated with cyclosporine and low doses of corticosteroids achieved a yearly growth rate that was more than twice that observed in the group treated with azathioprine and high doses of corticosteroids. Also, the adult height (which was measured at 18 years for males and at 16 years for females) of the cyclosporine group was 1.3 centimeters (cm) more than predicted. In the azathioprine group, the adult heights were an average of 3.9 cm less than predicted. No significant renal insufficiency occurred in the patients given cyclosporine, but kidney function in these patients was lower compared with the azathioprine group. It is concluded that maintenance with cyclosporine and low doses of prednisolone in young kidney transplant recipients is related to a better growth outcome and normal bone maturation in these patients. (Consumer Summary produced by Reliance Medical Information, Inc.)

Published
1990

49. Low levels of urinary epidermal growth factor predict chronic kidney disease progression in children

Author

Azukaitis, Karolis, primary, Ju, Wenjun, additional, Kirchner, Marietta, additional, Nair, Viji, additional, Smith, Michelle, additional, Fang, Zhiyin, additional, Thurn-Valsassina, Daniela, additional, Bayazit, Aysun, additional, Niemirska, Anna, additional, Canpolat, Nur, additional, Bulut, Ipek Kaplan, additional, Yalcinkaya, Fatos, additional, Paripovic, Dusan, additional, Harambat, Jerome, additional, Cakar, Nilgun, additional, Alpay, Harika, additional, Lugani, Francesca, additional, Mencarelli, Francesca, additional, Civilibal, Mahmut, additional, Erdogan, Hakan, additional, Gellermann, Jutta, additional, Vidal, Enrico, additional, Tabel, Yilmaz, additional, Gimpel, Charlotte, additional, Ertan, Pelin, additional, Yavascan, Onder, additional, Melk, Anette, additional, Querfeld, Uwe, additional, Wühl, Elke, additional, Kretzler, Matthias, additional, Schaefer, Franz, additional, Arbeiter, Klaus, additional, Rosales, Alejandra, additional, Dusek, Jiri, additional, Zaloszyc, Ariane, additional, Liebau, Max, additional, Weber, Lutz, additional, Muschiol, Evelin, additional, Büscher, Rainer, additional, Oh, Jun, additional, Thurn-Valassina, Daniela, additional, Haffner, Dieter, additional, John, Ulrike, additional, Wygoda, Simone, additional, Jeck, Nikola, additional, Wigger, Marianne, additional, Testa, Sara, additional, Murer, Luisa, additional, Matteucci, Chiara, additional, Jankauskiene, Augustina, additional, Azukaitis, Karolis, additional, Drozdz, Dorota, additional, Zurowska, Aleksandra, additional, Zaniew, Marcin, additional, Litwin, Mieczyslaw, additional, Nimierska, Anna, additional, Teixeira, Ana, additional, Peco-Antic, Amira, additional, Laube, Guido, additional, Anarat, Ali, additional, Duzova, Ali, additional, Bilginer, Yelda, additional, Caliskan, Salim, additional, Mir, Sevgi, additional, Sözeri, Betül, additional, Kranz, Brigitta, additional, Dorn, Brigitte, additional, Baskin, Esra, additional, Soylemezoglu, Oguz, additional, Emre, Sevinc, additional, Candan, Cengiz, additional, Kiyak, Aysel, additional, Ozcelik, Gul, additional, Shroff, Rukshana, additional, Rachin, Bruno, additional, Szczepanska, Maria, additional, Donmez, Osman, additional, Balat, Ayse, additional, Aksu, Nejat, additional, Yilmaz, Ebru, additional, Bakkaloglu, Aysin, additional, Ozaltin, Fatih, additional, Sallay, Peter, additional, Drożdż, Dorota, additional, Bonzel, Klaus-Eugen, additional, Wingen, Anna-Margrete, additional, Żurowska, Aleksandra, additional, Balasz, Irena, additional, Trivelli, Antonella, additional, Perfumo, Francesco, additional, Müller-Wiefel, Dirk-Erhard, additional, Möller, Kerstin, additional, Offner, Gisela, additional, Enke, Barbara, additional, Hadtstein, Charlotte, additional, Mehls, Otto, additional, Hohbach-Hohenfellner, Katharina, additional, Jeck, Nickola, additional, Klaus, Günter, additional, Ardissino, Gianluigi, additional, Montini, Giovanni, additional, Charbit, Marina, additional, Niaudet, Patrick, additional, Afonso, Alberto Caldas, additional, Fernandes-Teixeira, Ana, additional, Dušek, Jiri, additional, Picca, Stefano, additional, Berg, Ulla B., additional, Celsi, Giovanni, additional, Fischbach, Michel, additional, Terzic, Joelle, additional, Fydryk, Janusz, additional, Urasinski, Tomasz, additional, Coppo, Rosanna, additional, Peruzzi, Licia, additional, Grenda, Ryszard, additional, and Neuhaus, Thomas J., additional

Published
2019
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